-- dump date 20140618_205142 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 861360000001 SEQ_END SEQ_END NC_014548.1 8528 8528 DR NC_014548.1; contig end 8528..8528 Arthrobacter arilaitensis Re117 861360000002 SEQ_END SEQ_END NC_014549.1 50407 50407 DR NC_014549.1; contig end 50407..50407 Arthrobacter arilaitensis Re117 861360000003 SEQ_END SEQ_END NC_014550.1 3859257 3859257 DR NC_014550.1; contig end 3859257..3859257 Arthrobacter arilaitensis Re117 YP_003915161.1 CDS AARI_pII00010 NC_014548.1 86 532 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 86..532 Arthrobacter arilaitensis Re117 9777833 YP_003915162.1 CDS AARI_pII00020 NC_014548.1 676 1659 R hypothetical protein complement(676..1659) Arthrobacter arilaitensis Re117 9777821 YP_003915163.1 CDS AARI_pII00030 NC_014548.1 2057 2260 R hypothetical protein complement(2057..2260) Arthrobacter arilaitensis Re117 9777822 YP_003915164.1 CDS AARI_pII00040 NC_014548.1 2372 2518 D hypothetical protein 2372..2518 Arthrobacter arilaitensis Re117 9777823 YP_003915165.1 CDS AARI_pII00050 NC_014548.1 2632 2946 R identified by match to protein family PF03551; PadR-like family transcriptional regulator complement(2632..2946) Arthrobacter arilaitensis Re117 9777824 YP_003915166.1 CDS AARI_pII00060 NC_014548.1 2997 3743 R identified by match to protein family PF03432: Relaxase/Mobilisation nuclease domain. Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation; mobilisation protein complement(2997..3743) Arthrobacter arilaitensis Re117 9777825 YP_003915167.1 CDS AARI_pII00070 NC_014548.1 3740 4222 R identified by match to protein family PF05713: bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region; mobilisation protein complement(3740..4222) Arthrobacter arilaitensis Re117 9777826 YP_003915168.1 CDS AARI_pII00080 NC_014548.1 4384 4587 D hypothetical protein 4384..4587 Arthrobacter arilaitensis Re117 9777827 YP_003915169.1 CDS AARI_pII00090 NC_014548.1 4775 5320 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.621 between position 22 and 23. 2 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 4775..5320 Arthrobacter arilaitensis Re117 9777828 YP_003915170.1 CDS AARI_pII00100 NC_014548.1 5450 5713 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.879) with cleavage site probability 0.323 between position 19 and 20. 2 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 5450..5713 Arthrobacter arilaitensis Re117 9777829 YP_003915171.1 CDS AARI_pII00110 NC_014548.1 6483 7031 D hypothetical protein 6483..7031 Arthrobacter arilaitensis Re117 9777830 YP_003915172.1 CDS AARI_pII00120 NC_014548.1 7028 7726 R match to PF00239. Possibly involved in site-specific recombination of DNA; putative resolvase complement(7028..7726) Arthrobacter arilaitensis Re117 9777831 YP_003915173.1 CDS AARI_pII00130 NC_014548.1 7842 8390 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.983) with cleavage site probability 0.615 between position 21 and 22; hypothetical protein 7842..8390 Arthrobacter arilaitensis Re117 9777832 YP_003915174.1 CDS AARI_pI00010 NC_014549.1 128 508 D identified by match to PF00436. The Escherichia coli single-strand binding protein binds tightly to single-stranded DNA (ss-DNA) and plays an important role in DNA replication, recombination and repair. Closely related variants of SSB are encoded in the genome of a variety of large self-transmissible plasmids; single-stranded DNA-binding protein 128..508 Arthrobacter arilaitensis Re117 9795859 YP_003915175.1 CDS AARI_pI00030 NC_014549.1 1392 1793 D similar to protein SP:Q9X550 (Corynebacterium glutamicum plasmid R-plasmid pAG1). Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.700 between position 26 and 27; hypothetical protein 1392..1793 Arthrobacter arilaitensis Re117 9795830 YP_003915176.1 CDS AARI_pI00040 NC_014549.1 1797 2246 D similar to protein SP:Q9X549 (Corynebacterium glutamicum plasmid R-plasmid pAG1). Match to PS51257: prokaryotic membrane lipoprotein lipid attachment site profile; hypothetical protein 1797..2246 Arthrobacter arilaitensis Re117 9795855 YP_003915177.1 CDS AARI_pI00050 NC_014549.1 2243 2995 D similar to protein SP:Q9X548 (Corynebacterium glutamicum plasmid R-plasmid pAG1); hypothetical protein 2243..2995 Arthrobacter arilaitensis Re117 9795838 YP_003915178.1 CDS AARI_pI00060 NC_014549.1 3031 3249 D match to PF00376: MerR family regulatory protein; putative DNA-binding protein 3031..3249 Arthrobacter arilaitensis Re117 9795820 YP_003915179.1 CDS AARI_pI00070 NC_014549.1 3252 4565 R identified by match to protein family PF00817. In Escherichia coli, the gene products of the umuDC operon play important roles in the ability to tolerate damage to its DNA; UmuC-like protein complement(3252..4565) Arthrobacter arilaitensis Re117 9795834 YP_003915180.1 CDS AARI_pI00080 NC_014549.1 4547 4978 R in Escherichia coli, the gene products of the umuDC operon play important roles in the ability to tolerate damage to its DNA; UmuD-like protein complement(4547..4978) Arthrobacter arilaitensis Re117 9795864 YP_003915181.1 CDS hsdR NC_014549.1 7258 10341 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system restriction subunit complement(7258..10341) Arthrobacter arilaitensis Re117 9795861 YP_003915182.1 CDS hsdS NC_014549.1 10328 11677 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system specificity subunit complement(10328..11677) Arthrobacter arilaitensis Re117 9795821 YP_003915183.1 CDS hsdM NC_014549.1 11674 13635 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system modification subunit complement(11674..13635) Arthrobacter arilaitensis Re117 9795840 YP_003915184.1 CDS AARI_pI00460 NC_014549.1 14835 16142 D transposase of ISAar19, ISL3 family 14835..16142 Arthrobacter arilaitensis Re117 9795853 YP_003915185.1 CDS AARI_pI00470 NC_014549.1 16567 16863 D transposase of ISAar4, IS3 family, IS3 group, orfA 16567..16863 Arthrobacter arilaitensis Re117 9795832 YP_003915186.1 CDS AARI_pI00480 NC_014549.1 16863 17753 D transposase of ISAar4, IS3 family, IS3 group, orfB 16863..17753 Arthrobacter arilaitensis Re117 9795827 YP_003915187.1 CDS AARI_pI00120 NC_014549.1 20225 20818 R match to PF00239. Possibly involved in site-specific recombination of DNA; putative resolvase complement(20225..20818) Arthrobacter arilaitensis Re117 9795817 YP_003915188.1 CDS AARI_pI00500 NC_014549.1 21002 22309 R transposase of ISAar19, ISL3 family complement(21002..22309) Arthrobacter arilaitensis Re117 9795818 YP_003915189.1 CDS AARI_pI00130 NC_014549.1 22488 22901 R hypothetical protein complement(22488..22901) Arthrobacter arilaitensis Re117 9795822 YP_003915190.1 CDS AARI_pI00140 NC_014549.1 23011 23637 R hypothetical protein complement(23011..23637) Arthrobacter arilaitensis Re117 9795856 YP_003915191.1 CDS AARI_pI00150 NC_014549.1 23639 24709 R hypothetical protein complement(23639..24709) Arthrobacter arilaitensis Re117 9795857 YP_003915192.1 CDS AARI_pI00160 NC_014549.1 24962 25207 D hypothetical protein 24962..25207 Arthrobacter arilaitensis Re117 9795851 YP_003915193.1 CDS fic NC_014549.1 25204 26022 D identified by match to PF02661: Fic protein family. cAMP may be a regulation factor in cell division of some bacteria. The Fic (filamentation induced by cAMP) protein is involved in the synthesis of PAB or folate. It would appear that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism and in these organisms cell division could be controlled by coordination of cAMP, Fic and Fts proteins; Fic family protein 25204..26022 Arthrobacter arilaitensis Re117 9795829 YP_003915194.1 CDS AARI_pI00180 NC_014549.1 26019 26693 D match to PF00239 and PF02796. Possibly involved in site-specific recombination of DNA; putative resolvase 26019..26693 Arthrobacter arilaitensis Re117 9795828 YP_003915195.1 CDS AARI_pI00190 NC_014549.1 26990 27409 R hypothetical protein complement(26990..27409) Arthrobacter arilaitensis Re117 9795850 YP_003915196.1 CDS AARI_pI00200 NC_014549.1 27639 28040 D identified by match to protein family PF05713: bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis-active site of a mobilising plasmid, the origin of transfer (oriT) region; mobilisation protein 27639..28040 Arthrobacter arilaitensis Re117 9795825 YP_003915197.1 CDS AARI_pI00210 NC_014549.1 28037 29746 D identified by match to protein family PF03432: Relaxase/Mobilisation nuclease domain. Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation; mobilisation protein 28037..29746 Arthrobacter arilaitensis Re117 9795846 YP_003915198.1 CDS AARI_pI00220 NC_014549.1 29762 30622 D hypothetical protein 29762..30622 Arthrobacter arilaitensis Re117 9795836 YP_003915199.1 CDS AARI_pI00230 NC_014549.1 31305 31667 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(31305..31667) Arthrobacter arilaitensis Re117 9795839 YP_003915200.1 CDS AARI_pI00240 NC_014549.1 31702 32454 R hypothetical protein complement(31702..32454) Arthrobacter arilaitensis Re117 9795844 YP_003915201.1 CDS AARI_pI00250 NC_014549.1 32451 34247 R identified by match to protein family PF02534. The TraG family are bacterial conjugation proteins. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome although the exact mechanism of action is unknown; TraG-family bacterial conjugation protein complement(32451..34247) Arthrobacter arilaitensis Re117 9795819 YP_003915202.1 CDS AARI_pI00260 NC_014549.1 34244 35872 R hypothetical protein complement(34244..35872) Arthrobacter arilaitensis Re117 9795815 YP_003915203.1 CDS AARI_pI00270 NC_014549.1 35869 37380 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(35869..37380) Arthrobacter arilaitensis Re117 9795837 YP_003915204.1 CDS AARI_pI00280 NC_014549.1 37367 39088 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(37367..39088) Arthrobacter arilaitensis Re117 9795862 YP_003915205.1 CDS AARI_pI00290 NC_014549.1 39095 39841 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(39095..39841) Arthrobacter arilaitensis Re117 9795854 YP_003915206.1 CDS AARI_pI00300 NC_014549.1 39856 40161 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(39856..40161) Arthrobacter arilaitensis Re117 9795860 YP_003915207.1 CDS AARI_pI00310 NC_014549.1 40158 40301 R hypothetical protein complement(40158..40301) Arthrobacter arilaitensis Re117 9795858 YP_003915208.1 CDS AARI_pI00320 NC_014549.1 40412 40870 D hypothetical protein 40412..40870 Arthrobacter arilaitensis Re117 9795835 YP_003915209.1 CDS AARI_pI00330 NC_014549.1 40937 41206 D match to protein family TIGR01764; putative excisionase 40937..41206 Arthrobacter arilaitensis Re117 9795845 YP_003915210.1 CDS AARI_pI00340 NC_014549.1 41208 41750 D similar to protein SP:Q9X549 (Corynebacterium glutamicum plasmid R-plasmid pAG1). Match to PS51257: prokaryotic membrane lipoprotein lipid attachment site profile; hypothetical protein 41208..41750 Arthrobacter arilaitensis Re117 9795833 YP_003915211.1 CDS AARI_pI00350 NC_014549.1 41753 42820 D identified by match to protein family PF01551. Members of this family are zinc metallopeptidases with a range of specificities. Peptidase family M23 are also endopeptidases. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0. 661 between position 37 and 38; putative secreted M23 family peptidase 41753..42820 Arthrobacter arilaitensis Re117 9795824 YP_003915212.1 CDS AARI_pI00360 NC_014549.1 42835 44235 D hypothetical protein 42835..44235 Arthrobacter arilaitensis Re117 9795843 YP_003915213.1 CDS AARI_pI00380 NC_014549.1 44733 44966 D match to SSF47598: Ribbon-helix-helix superfamily; ribbon-helix-helix domain-containing protein 44733..44966 Arthrobacter arilaitensis Re117 9795852 YP_003915214.1 CDS AARI_pI00390 NC_014549.1 45210 47144 D hypothetical protein 45210..47144 Arthrobacter arilaitensis Re117 9795823 YP_003915215.1 CDS AARI_pI00400 NC_014549.1 47652 48539 D hypothetical protein 47652..48539 Arthrobacter arilaitensis Re117 9795849 YP_003915216.1 CDS AARI_pI00410 NC_014549.1 48636 48773 D hypothetical protein 48636..48773 Arthrobacter arilaitensis Re117 9795831 YP_003915217.1 CDS AARI_pI00420 NC_014549.1 48855 49262 D hypothetical protein 48855..49262 Arthrobacter arilaitensis Re117 9795826 YP_003915218.1 CDS AARI_pI00430 NC_014549.1 49324 49536 D hypothetical protein 49324..49536 Arthrobacter arilaitensis Re117 9795842 YP_003915219.1 CDS AARI_pI00440 NC_014549.1 49624 49881 D identified by match to protein family PF00462; glutaredoxin-like protein 49624..49881 Arthrobacter arilaitensis Re117 9795841 YP_003915220.1 CDS AARI_pI00450 NC_014549.1 49935 50195 D hypothetical protein 49935..50195 Arthrobacter arilaitensis Re117 9795847 YP_003915221.1 CDS dnaA NC_014550.1 353 1789 D plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; chromosomal replication initiator protein DnaA 353..1789 Arthrobacter arilaitensis Re117 9795865 YP_003915222.1 CDS dnaN NC_014550.1 2256 3383 D DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit beta 2256..3383 Arthrobacter arilaitensis Re117 9793820 YP_003915223.1 CDS recF NC_014550.1 3442 4605 D RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication fork, allowing it to resume and complete its task.; DNA replication and repair protein RecF 3442..4605 Arthrobacter arilaitensis Re117 9793827 YP_003915224.1 CDS AARI_00040 NC_014550.1 4598 5155 D match to protein family PF05258. This family contains several actinomycete proteins of unknown function; hypothetical protein 4598..5155 Arthrobacter arilaitensis Re117 9794287 YP_003915225.1 CDS gyrB NC_014550.1 5438 7501 D DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings. Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis; DNA gyrase subunit B 5438..7501 Arthrobacter arilaitensis Re117 9795866 YP_003915226.1 CDS gyrA NC_014550.1 7560 10187 D DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings. Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis; DNA gyrase subunit A 7560..10187 Arthrobacter arilaitensis Re117 9793944 YP_003915227.1 CDS AARI_00070 NC_014550.1 10184 10807 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 10184..10807 Arthrobacter arilaitensis Re117 9793943 YP_003915228.1 CDS AARI_00080 NC_014550.1 11465 12640 R match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 complement(11465..12640) Arthrobacter arilaitensis Re117 9793565 YP_003915229.1 CDS AARI_00090 NC_014550.1 12719 13690 D identified by match to protein family PF01758. Bile acid:Na+ symporter (BASS) family (TC 2.A.28.y.z): these symporters exhibit broad specificity, taking up a variety of non bile organic compounds as well as taurocholate and other bile salts; sodium-dependent transporter 12719..13690 Arthrobacter arilaitensis Re117 9795868 YP_003915230.1 CDS AARI_00100 NC_014550.1 13822 14691 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.973) with cleavage site probability 0.306 between position 22 and 23. 8 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 13822..14691 Arthrobacter arilaitensis Re117 9795869 YP_003915231.1 CDS AARI_00110 NC_014550.1 14698 14904 R hypothetical protein complement(14698..14904) Arthrobacter arilaitensis Re117 9795870 YP_003915232.1 CDS ppiA NC_014550.1 15075 15620 D identified by match to protein family PF00160: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. Peptidylprolyl isomerase is an enzyme that accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidylprolyl isomerase 15075..15620 Arthrobacter arilaitensis Re117 9795871 YP_003915233.1 CDS AARI_00130 NC_014550.1 15722 16579 D identified by match to protein family PF01694. This group of proteins contain serine peptidases belonging to the MEROPS peptidase family S54 (Rhomboid, clan S-). They are integral membrane proteins related to the Drosophila melanogaster (Fruit fly) rhomboid protein. 7 transmembrane helices predicted by TMHMM2.0; rhomboid family protein 15722..16579 Arthrobacter arilaitensis Re117 9794217 YP_003915234.1 CDS lysE NC_014550.1 17061 17678 R L-lysine exporter (LysE) family, L-lysine exporter (TC 2.A.75.1.1). Identified by match to protein family PF01810. In Corynebacterium glutamicum, LysE appears to catalyze unidirectional efflux of L-lysine (and other basic amino acids such as L-arginine). The physiological function of the exporter is to excrete excess l-Lysine as a result of natural flux imbalances; L-lysine exporter complement(17061..17678) Arthrobacter arilaitensis Re117 9795872 YP_003915235.1 CDS lysG NC_014550.1 17749 18633 D probable transcriptional regulator of lysE. Identified by similarity to protein SP: P94632 (Corynebacterium glutamicum); lysine export transcriptional regulatory protein LysG 17749..18633 Arthrobacter arilaitensis Re117 9794050 YP_003915236.1 CDS sugE NC_014550.1 18716 19033 D drug/metabolite transporter (DMT) superfamily, small multidrug resistance (SMR) family, quaternary ammonium compound (cetylpyridinium, cetyldimethyl ethylammonium, hexadecyltrimethyl ammonium) efflux pump (TC 2.A.7.1.4). Confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 18716..19033 Arthrobacter arilaitensis Re117 9794051 YP_003915237.1 CDS AARI_00170 NC_014550.1 19094 19351 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(19094..19351) Arthrobacter arilaitensis Re117 9794418 YP_003915238.1 CDS AARI_00180 NC_014550.1 19574 20350 D identified by match to protein family PF04203. Sortase is a transpeptidase that attaches surface proteins by the threonine of an LPXTG motif to the cell wall; sortase 19574..20350 Arthrobacter arilaitensis Re117 9795873 YP_003915239.1 CDS AARI_00190 NC_014550.1 20359 20529 D hypothetical protein 20359..20529 Arthrobacter arilaitensis Re117 9795874 YP_003915240.1 CDS trpG NC_014550.1 20526 21170 D anthranilate synthase is the first enzyme in the branch pathway in tryptophane biosynthesis. It catalyzes the biosynthesis of anthranilate from chorismate and glutamine; anthranilate synthase component II 20526..21170 Arthrobacter arilaitensis Re117 9795875 YP_003915241.1 CDS AARI_00210 NC_014550.1 21263 21787 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(21263..21787) Arthrobacter arilaitensis Re117 9794472 YP_003915242.1 CDS AARI_00220 NC_014550.1 22056 22346 D hypothetical protein 22056..22346 Arthrobacter arilaitensis Re117 9795876 YP_003915243.1 CDS AARI_00230 NC_014550.1 22423 22902 R identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase complement(22423..22902) Arthrobacter arilaitensis Re117 9795877 YP_003915244.1 CDS AARI_00240 NC_014550.1 23100 23429 D hypothetical protein 23100..23429 Arthrobacter arilaitensis Re117 9795878 YP_003915245.1 CDS AARI_00320 NC_014550.1 27827 28318 R identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein complement(27827..28318) Arthrobacter arilaitensis Re117 9795886 YP_003915246.1 CDS AARI_00330 NC_014550.1 28611 30524 R identified by match to protein domain PD000001. Match to PS00108 pattern. Protein kinases are a group of enzymes that possess a catalytic subunit which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. They play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiation; Ser/Thr protein kinase complement(28611..30524) Arthrobacter arilaitensis Re117 9795887 YP_003915247.1 CDS AARI_00340 NC_014550.1 30521 32326 R identified by match to protein domain PD000001. Match to PS00108 pattern. Protein kinases are a group of enzymes that possess a catalytic subunit which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. They play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiation; Ser/Thr protein kinase complement(30521..32326) Arthrobacter arilaitensis Re117 9795888 YP_003915248.1 CDS AARI_00350 NC_014550.1 32323 33786 R match to PF00905. The large number of penicillin binding proteins, which are represented in this group of sequences, are responsible for the final stages of peptidoglycan biosynthesis for cell wall formation. The proteins synthesise cross-linked peptidoglycan from lipid intermediates, and contain a penicillin-sensitive transpeptidase carboxy-terminal domain; penicillin-binding protein complement(32323..33786) Arthrobacter arilaitensis Re117 9795889 YP_003915249.1 CDS ftsW NC_014550.1 33783 35180 R plays a role in the stabilization of the FtsZ ring during cell division; cell division protein FtsW complement(33783..35180) Arthrobacter arilaitensis Re117 9795890 YP_003915250.1 CDS AARI_00370 NC_014550.1 35177 36571 R match to PF00481: protein phosphatase 2C; protein phosphatase domain-containing protein complement(35177..36571) Arthrobacter arilaitensis Re117 9793867 YP_003915251.1 CDS AARI_00380 NC_014550.1 36575 37054 R match to PF00498. The forkhead-associated (FHA) domain is a phosphopeptide recognition domain found in many regulatory proteins; FHA domain-containing protein complement(36575..37054) Arthrobacter arilaitensis Re117 9795891 YP_003915252.1 CDS AARI_00390 NC_014550.1 37051 37866 R match to PF00498. The forkhead-associated (FHA) domain is a phosphopeptide recognition domain found in many regulatory proteins; FHA domain-containing protein complement(37051..37866) Arthrobacter arilaitensis Re117 9795892 YP_003915253.1 CDS AARI_00400 NC_014550.1 38316 38771 R hypothetical protein complement(38316..38771) Arthrobacter arilaitensis Re117 9793566 YP_003915254.1 CDS AARI_00410 NC_014550.1 38850 39386 D hypothetical protein 38850..39386 Arthrobacter arilaitensis Re117 9795894 YP_003915255.1 CDS AARI_00420 NC_014550.1 39375 39536 R hypothetical protein complement(39375..39536) Arthrobacter arilaitensis Re117 9795895 YP_003915256.1 CDS AARI_00430 NC_014550.1 39546 40595 R match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator complement(39546..40595) Arthrobacter arilaitensis Re117 9795896 YP_003915257.1 CDS iunH NC_014550.1 40746 41717 D catalyzes the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates; inosine/uridine-preferring nucleoside hydrolase 40746..41717 Arthrobacter arilaitensis Re117 9795897 YP_003915258.1 CDS AARI_00450 NC_014550.1 41805 42503 D identified by match to PF01738: dienelactone hydrolase family. Carboxymethylenebutenolidases play a crucial role in chlorocatechol degradation via the modified ortho cleavage pathway; carboxymethylenebutenolidase 41805..42503 Arthrobacter arilaitensis Re117 9794023 YP_003915259.1 CDS AARI_00460 NC_014550.1 42559 42990 D identified by match to PF00582: universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general stress endurance activity; universal stress family domain-containing protein 42559..42990 Arthrobacter arilaitensis Re117 9795898 YP_003915260.1 CDS AARI_00470 NC_014550.1 43078 43794 D lysR family transcriptional regulator 43078..43794 Arthrobacter arilaitensis Re117 9795899 YP_003915261.1 CDS AARI_00480 NC_014550.1 43837 44625 D match to protein family PF00378. This family contains a diverse set of enzymes including: Enoyl-CoA hydratase, Napthoate synthase, Carnitate racemase, 3- hydoxybutyryl-CoA dehydratase, Dodecanoyl-CoA delta- isomerase; enoyl-CoA hydratase/isomerase 43837..44625 Arthrobacter arilaitensis Re117 9795900 YP_003915262.1 CDS AARI_00490 NC_014550.1 44640 45305 D hypothetical protein 44640..45305 Arthrobacter arilaitensis Re117 9795901 YP_003915263.1 CDS AARI_00500 NC_014550.1 45315 46214 D fructokinase catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate; fructokinase 45315..46214 Arthrobacter arilaitensis Re117 9795902 YP_003915264.1 CDS AARI_00510 NC_014550.1 46215 47009 D match to protein family PF08282: haloacid dehalogenase-like hydrolase. The Haloacid Dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P- type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification; haloacid dehalogenase 46215..47009 Arthrobacter arilaitensis Re117 9795903 YP_003915265.1 CDS glpQ NC_014550.1 47006 47737 D glycerophosphoryl diester phosphodiesterases display broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol); glycerophosphodiester phosphodiesterase 47006..47737 Arthrobacter arilaitensis Re117 9795904 YP_003915266.1 CDS AARI_00530 NC_014550.1 47734 48711 R hypothetical protein complement(47734..48711) Arthrobacter arilaitensis Re117 9793912 YP_003915267.1 CDS AARI_00540 NC_014550.1 48804 51986 D glycosyl hydrolase family 65 protein 48804..51986 Arthrobacter arilaitensis Re117 9795905 YP_003915268.1 CDS AARI_00550 NC_014550.1 52080 53486 R major facilitator superfamily, sugar porter family (TC 2.A.1.1.z); MFS superfamily sugar transporter complement(52080..53486) Arthrobacter arilaitensis Re117 9795906 YP_003915269.1 CDS AARI_00560 NC_014550.1 53700 54983 R nucleobase:cation symporter-2 (NCS2) Family (TC 2.A. 40.y.z). Identified by match to protein family PF00860; uracil/xanthine permease complement(53700..54983) Arthrobacter arilaitensis Re117 9795907 YP_003915270.1 CDS thiD NC_014550.1 55011 56435 R involved in thiamin biosynthesis. Catalyzes the phosphorylation of HMP-P to HMP-PP; phosphomethylpyrimidine kinase complement(55011..56435) Arthrobacter arilaitensis Re117 9795908 YP_003915271.1 CDS thiE NC_014550.1 56432 57073 R catalyses the following reaction: 2-methyl-4-amino- 5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2- phosphono-oxyethyl)thiazole <=> diphosphate + thiamine phosphate; thiamine-phosphate diphosphorylase complement(56432..57073) Arthrobacter arilaitensis Re117 9794440 YP_003915272.1 CDS thiM NC_014550.1 57066 57860 R catalyses the following reaction : ATP + 4-methyl-5- (2-hydroxyethyl)thiazole <=> ADP + 4-methyl-5-(2- phosphonooxyethyl)thiazole; hydroxyethylthiazole kinase complement(57066..57860) Arthrobacter arilaitensis Re117 9794441 YP_003915273.1 CDS AARI_00600 NC_014550.1 57979 58347 R transcriptional regulator complement(57979..58347) Arthrobacter arilaitensis Re117 9794445 YP_003915274.1 CDS AARI_00610 NC_014550.1 58344 59882 R 12 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(58344..59882) Arthrobacter arilaitensis Re117 9795909 YP_003915275.1 CDS AARI_00620 NC_014550.1 59963 61396 D identified by match to protein family PF00171; aldehyde dehydrogenase family protein 59963..61396 Arthrobacter arilaitensis Re117 9795910 YP_003915276.1 CDS lysP NC_014550.1 61476 62924 D amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family, lysine:H+ symporter (TC 2.A.3.1.2). Identified by similarity to protein SP:P25737 (Escherichia coli); lysine-specific permease 61476..62924 Arthrobacter arilaitensis Re117 9795911 YP_003915277.1 CDS pgm NC_014550.1 62921 64519 R catalyzes the interconversion of alpha-D-glucose 1- phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase complement(62921..64519) Arthrobacter arilaitensis Re117 9794052 YP_003915278.1 CDS AARI_00660 NC_014550.1 64978 66435 R proton-dependent oligopeptide transporter (POT) family (TC 2.A.17), di- or tripeptide:H+ symporter (TC 2.A. 17.1.1). Identified by match to protein family PF00854; dipeptide/tripeptide permease complement(64978..66435) Arthrobacter arilaitensis Re117 9795912 YP_003915279.1 CDS AARI_00670 NC_014550.1 66488 67834 R amidase complement(66488..67834) Arthrobacter arilaitensis Re117 9795913 YP_003915280.1 CDS AARI_00680 NC_014550.1 67902 68228 D identified by match to protein domain PF00581. Rhodanese has an internal duplication. This HMM represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases; rhodanese domain-containing protein 67902..68228 Arthrobacter arilaitensis Re117 9795914 YP_003915281.1 CDS AARI_00690 NC_014550.1 68225 69148 D catalyzes the decarboxylation of prephenate into phenylpyruvate. Involved in phenylalanine biosynthesis; prephenate dehydratase 68225..69148 Arthrobacter arilaitensis Re117 9795915 YP_003915282.1 CDS AARI_00700 NC_014550.1 69219 70265 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.916 between position 19 and 20; hypothetical protein complement(69219..70265) Arthrobacter arilaitensis Re117 9795916 YP_003915283.1 CDS serS NC_014550.1 70304 71581 D activates serine and transfers it to tRNA(Ser) as the first step in protein biosynthesis; serine--tRNA ligase 70304..71581 Arthrobacter arilaitensis Re117 9795917 YP_003915284.1 CDS AARI_00720 NC_014550.1 71706 72536 D match to protein family PF08282: haloacid dehalogenase-like hydrolase. The Haloacid Dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P- type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification; haloacid dehalogenase 71706..72536 Arthrobacter arilaitensis Re117 9794395 YP_003915285.1 CDS AARI_00730 NC_014550.1 72555 73157 R hypothetical protein complement(72555..73157) Arthrobacter arilaitensis Re117 9795918 YP_003915286.1 CDS pcp NC_014550.1 74302 74961 R selectively removes pyroglutamate (pGlu) from the N- terminus of proteins and peptides. The enzyme appears to play an important role in the activation and inactivation of many N-terminal pyroglutamyl-terminating peptides; pyroglutamyl-peptidase I complement(74302..74961) Arthrobacter arilaitensis Re117 9795921 YP_003915287.1 CDS AARI_00770 NC_014550.1 75044 76252 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 75044..76252 Arthrobacter arilaitensis Re117 9794188 YP_003915288.1 CDS AARI_00780 NC_014550.1 76314 76655 D hypothetical protein 76314..76655 Arthrobacter arilaitensis Re117 9795922 YP_003915289.1 CDS ppa NC_014550.1 76714 77193 R responsible for the hydrolysis of pyrophosphate (PPi) which is formed principally as the product of the many biosynthetic reactions that utilize ATP; inorganic diphosphatase complement(76714..77193) Arthrobacter arilaitensis Re117 9795923 YP_003915290.1 CDS AARI_00800 NC_014550.1 77291 78655 D identified by match to protein family PF02113. Is involved in the metabolism of cell components; it is synthesised with a leader peptide to target it to the cell membrane. Preferential cleavage: (Ac)(2)-L-Lys-D-Ala-|-D- Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine; serine-type D-Ala-D-Ala carboxypeptidase 77291..78655 Arthrobacter arilaitensis Re117 9794215 YP_003915291.1 CDS AARI_00810 NC_014550.1 78674 79600 D hypothetical protein 78674..79600 Arthrobacter arilaitensis Re117 9795924 YP_003915292.1 CDS tilS NC_014550.1 79597 80523 D ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine; tRNA(Ile)-lysidine synthase 79597..80523 Arthrobacter arilaitensis Re117 9795925 YP_003915293.1 CDS hpt NC_014550.1 80588 81139 D catalyses the formation of IMP and diphosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate. Guanine and 6-mercaptopurine can replace hypoxanthine. This enzyme is essential for salvaging exogenous purine bases; hypoxanthine phosphoribosyltransferase 80588..81139 Arthrobacter arilaitensis Re117 9794454 YP_003915294.1 CDS ftsH NC_014550.1 81247 83172 D FtsH is a membrane-anchored ATP-dependent protease that degrades misfolded or misassembled membrane proteins as well as a subset of cytoplasmic regulatory proteins. 2 transmembrane helices predicted by TMHMM2.0; cell division protein FtsH 81247..83172 Arthrobacter arilaitensis Re117 9793975 YP_003915295.1 CDS folE NC_014550.1 83182 83760 D catalyzes the biosynthesis of formic acid and dihydroneopterin triphosphate from GTP : GTP + H2O <=> formate + 2-amino-4-hydroxy-6-(erythro-1,2,3- trihydroxypropyl)- dihydropteridine triphosphate; GTP cyclohydrolase I 83182..83760 Arthrobacter arilaitensis Re117 9793865 YP_003915296.1 CDS folP NC_014550.1 83769 84671 D catalyzes the condensation of 6-hydroxymethyl-7,8- dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7,8-dihydropteroate. This is the second step in the three steps pathway leading from 6-hydroxymethyl-7,8- dihydropterin to 7,8-dihydrofolate. It is the target of sulfonamides which are substrates analog that compete with para-aminobenzoic acid; dihydropteroate synthase 83769..84671 Arthrobacter arilaitensis Re117 9793860 YP_003915297.1 CDS folBK NC_014550.1 84658 85491 D EC 4.1.2.25 catalyzes the following reaction: 2- amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7, 8- dihydropteridine <=> 2-amino-4-hydroxy-6-hydroxymethyl-7, 8- dihydropteridine + glycolaldehyde. EC 2.7.6.3 catalyses the following reaction: ATP + 2-amino-4-hydroxy-6- hydroxymethyl-7,8-dihydropteridine <=> AMP + (2-amino-4- hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate; bifunctional dihydroneopterin aldolase/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 84658..85491 Arthrobacter arilaitensis Re117 9793861 YP_003915298.1 CDS AARI_00880 NC_014550.1 85488 85949 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.991) with cleavage site probability 0.734 between position 31 and 32. 3 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 85488..85949 Arthrobacter arilaitensis Re117 9793857 YP_003915299.1 CDS AARI_00890 NC_014550.1 85975 86415 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 85975..86415 Arthrobacter arilaitensis Re117 9795926 YP_003915300.1 CDS AARI_00900 NC_014550.1 86412 87809 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 86412..87809 Arthrobacter arilaitensis Re117 9795927 YP_003915301.1 CDS AARI_00910 NC_014550.1 87812 88678 D hypothetical protein 87812..88678 Arthrobacter arilaitensis Re117 9795928 YP_003915302.1 CDS panC NC_014550.1 88683 89549 D catalyzes the formation of pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 88683..89549 Arthrobacter arilaitensis Re117 9795929 YP_003915303.1 CDS AARI_00930 NC_014550.1 89546 90499 R identified by match to protein family PF03060: 2- nitropropane dioxygenase; 2-nitropropane dioxygenase-like protein complement(89546..90499) Arthrobacter arilaitensis Re117 9794174 YP_003915304.1 CDS AARI_00940 NC_014550.1 96904 96996 D hypothetical protein 96904..96996 Arthrobacter arilaitensis Re117 9793569 YP_003915305.1 CDS AARI_00950 NC_014550.1 97559 97759 D match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein 97559..97759 Arthrobacter arilaitensis Re117 9795931 YP_003915306.1 CDS AARI_00960 NC_014550.1 97756 98952 D identified by match to PF07804 (HipA-like C- terminal domain) and PF07805 (HipA-like N-terminal domain). The HipA protein is known to be involved in high- frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells but it is usually tightly associated with HipB and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products; HipA-like protein 97756..98952 Arthrobacter arilaitensis Re117 9795932 YP_003915307.1 CDS AARI_00970 NC_014550.1 98974 99417 R hypothetical protein complement(98974..99417) Arthrobacter arilaitensis Re117 9795933 YP_003915308.1 CDS AARI_00980 NC_014550.1 106102 108075 D identified by match to PF05649 and PF01431; metalloproteinase 106102..108075 Arthrobacter arilaitensis Re117 9793572 YP_003915309.1 CDS lysS NC_014550.1 108213 109727 D lysine-tRNA ligase 108213..109727 Arthrobacter arilaitensis Re117 9795935 YP_003915310.1 CDS AARI_01000 NC_014550.1 109729 109896 D hypothetical protein 109729..109896 Arthrobacter arilaitensis Re117 9794054 YP_003915311.1 CDS AARI_01010 NC_014550.1 110035 110355 D hypothetical protein 110035..110355 Arthrobacter arilaitensis Re117 9795936 YP_003915312.1 CDS clpC NC_014550.1 110617 113139 D ATP-dependent Clp proteases act as chaperones to target the proteases to substrates; ATP-dependent Clp protease ATP-binding subunit 110617..113139 Arthrobacter arilaitensis Re117 9795937 YP_003915313.1 CDS AARI_01030 NC_014550.1 113231 113698 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 113231..113698 Arthrobacter arilaitensis Re117 9793738 YP_003915314.1 CDS AARI_01040 NC_014550.1 113730 114176 R hypothetical protein complement(113730..114176) Arthrobacter arilaitensis Re117 9795938 YP_003915315.1 CDS AARI_01050 NC_014550.1 114189 114596 R identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein complement(114189..114596) Arthrobacter arilaitensis Re117 9795939 YP_003915316.1 CDS AARI_01060 NC_014550.1 114644 115042 R identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family; AraC family transcriptional regulator complement(114644..115042) Arthrobacter arilaitensis Re117 9795940 YP_003915317.1 CDS AARI_01070 NC_014550.1 115046 116230 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(115046..116230) Arthrobacter arilaitensis Re117 9795941 YP_003915318.1 CDS AARI_01080 NC_014550.1 116394 116903 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 116394..116903 Arthrobacter arilaitensis Re117 9795942 YP_003915319.1 CDS AARI_01090 NC_014550.1 116909 117709 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(116909..117709) Arthrobacter arilaitensis Re117 9795943 YP_003915320.1 CDS mutY NC_014550.1 117774 118682 R identified by match to protein domain PF00730. This domain is found in a diverse range of structurally related DNA repair proteins that include: endonuclease III, and DNA glycosylase MutY, an A/G-specific adenine glycosylase. Both of these enzymes have a C terminal iron-sulphur cluster loop (FCL); A/G-specific DNA glycosylase complement(117774..118682) Arthrobacter arilaitensis Re117 9795944 YP_003915321.1 CDS AARI_01110 NC_014550.1 118805 119422 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 118805..119422 Arthrobacter arilaitensis Re117 9794125 YP_003915322.1 CDS disA NC_014550.1 119428 120501 R participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged; DNA integrity scanning protein DisA complement(119428..120501) Arthrobacter arilaitensis Re117 9795945 YP_003915323.1 CDS radA NC_014550.1 120536 121930 R may play a role in the repair of endogenous alkylation damage; DNA repair protein RadA complement(120536..121930) Arthrobacter arilaitensis Re117 9793815 YP_003915324.1 CDS AARI_01140 NC_014550.1 121966 123108 R hypothetical protein complement(121966..123108) Arthrobacter arilaitensis Re117 9794280 YP_003915325.1 CDS pstS NC_014550.1 123321 124436 D TCDB: ATP-binding cassette (ABC) superfamily, phosphate uptake transporter (PhoT) family, phosphate transporter (TC 3.A.1.7.2). ABCISSE: ABC transporter, binding protein (BP), MOI-family, phosphate import. Part of the ABC transporter complex PstSACB involved in phosphate import. The complex is composed of two ATP- binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS); phosphate ABC transporter substrate-binding protein PstS 123321..124436 Arthrobacter arilaitensis Re117 9795946 YP_003915326.1 CDS pstC NC_014550.1 124556 125491 D TCDB: ATP-binding cassette (ABC) superfamily, phosphate uptake transporter (PhoT) family, phosphate transporter (TC 3.A.1.7.2). ABCISSE: ABC transporter, permease (IM), MOI-family, phosphate import. Part of the ABC transporter complex pstSACB involved in phosphate import. The complex is composed of two ATP-binding proteins (pstB), two transmembrane proteins (pstC and pstA) and a solute-binding protein (pstS); phosphate ABC transporter inner membrane subunit PstC 124556..125491 Arthrobacter arilaitensis Re117 9794238 YP_003915327.1 CDS pstA NC_014550.1 125491 126630 D TCDB: ATP-binding cassette (ABC) superfamily, phosphate uptake transporter (PhoT) family, phosphate transporter (TC 3.A.1.7.2). ABCISSE: ABC transporter, permease (IM), MOI-family, phosphate import. Part of the ABC transporter complex pstSACB involved in phosphate import. The complex is composed of two ATP-binding proteins (pstB), two transmembrane proteins (pstC and pstA) and a solute-binding protein (pstS); phosphate ABC transporter inner membrane subunit PstA 125491..126630 Arthrobacter arilaitensis Re117 9794237 YP_003915328.1 CDS pstB NC_014550.1 126677 127456 D TCDB: ATP-binding cassette (ABC) superfamily, phosphate uptake transporter (PhoT) family, phosphate transporter (TC 3.A.1.7.2). ABCISSE: ABC transporter, ATP- binding protein (ABC), MOI-family, phosphate import. Part of the ABC transporter complex pstSACB involved in phosphate import. The complex is composed of two ATP- binding proteins (pstB), two transmembrane proteins (pstC and pstA) and a solute-binding protein (pstS); phosphate ABC transporter ATP-binding subunit PstB 126677..127456 Arthrobacter arilaitensis Re117 9794235 YP_003915329.1 CDS AARI_01190 NC_014550.1 127466 127585 D hypothetical protein 127466..127585 Arthrobacter arilaitensis Re117 9794236 YP_003915330.1 CDS AARI_01200 NC_014550.1 127667 128134 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 127667..128134 Arthrobacter arilaitensis Re117 9795947 YP_003915331.1 CDS AARI_01210 NC_014550.1 128134 128625 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 128134..128625 Arthrobacter arilaitensis Re117 9796029 YP_003915332.1 CDS AARI_01220 NC_014550.1 128625 128822 D match to protein domain PF01381: helix-turn-helix; transcriptional regulator 128625..128822 Arthrobacter arilaitensis Re117 9796030 YP_003915333.1 CDS AARI_01230 NC_014550.1 128819 129847 R inorganic phosphate transporter (PiT) family (TC 2. A.20.y.z). Identified by match to protein family PF01384; phosphate transporter complement(128819..129847) Arthrobacter arilaitensis Re117 9796031 YP_003915334.1 CDS AARI_01240 NC_014550.1 129852 130481 R hypothetical protein complement(129852..130481) Arthrobacter arilaitensis Re117 9796032 YP_003915335.1 CDS AARI_01250 NC_014550.1 130526 130645 D hypothetical protein 130526..130645 Arthrobacter arilaitensis Re117 9796033 YP_003915336.1 CDS AARI_01260 NC_014550.1 130841 131086 D hypothetical protein 130841..131086 Arthrobacter arilaitensis Re117 9796034 YP_003915337.1 CDS AARI_34370 NC_014550.1 131139 132584 D transposase of ISAar22, IS481 family 131139..132584 Arthrobacter arilaitensis Re117 9796035 YP_003915338.1 CDS AARI_01280 NC_014550.1 133717 134382 R hypothetical protein complement(133717..134382) Arthrobacter arilaitensis Re117 9796036 YP_003915339.1 CDS AARI_01290 NC_014550.1 134707 135297 R identified by match to PF01738: dienelactone hydrolase family; dienelactone hydrolase domain-containing protein complement(134707..135297) Arthrobacter arilaitensis Re117 9793573 YP_003915340.1 CDS AARI_01300 NC_014550.1 135316 135567 R hypothetical protein complement(135316..135567) Arthrobacter arilaitensis Re117 9796038 YP_003915341.1 CDS AARI_01310 NC_014550.1 135643 137247 R TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-1 (Drug RA1) family (TC 3.A.1.120.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family. Duplicated ATPase domains (PF00005); drug resistance ATP-binding protein complement(135643..137247) Arthrobacter arilaitensis Re117 9796039 YP_003915342.1 CDS AARI_01320 NC_014550.1 137461 138243 R identified by match to protein family PF02517: CAAX amino terminal protease family. Members of this family are probably proteases (after a prenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein, the AAX tripeptide is removed by one of the CAAX prenyl proteases). The family contains the Q03530 CAAX prenyl protease. Signal peptide predicted by SignalP 3.0 HMM (probability: 0.755) with cleavage site probability 0.459 between position 27 and 28. 5 transmembrane helices predicted by TMHMM2.0 after the signal peptide; CAAX amino terminal protease complement(137461..138243) Arthrobacter arilaitensis Re117 9796040 YP_003915343.1 CDS AARI_01330 NC_014550.1 138406 139107 R converts dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and converts 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4- benzoquinol (DMQH2); ubiquinone/menaquinone biosynthesis methyltransferase complement(138406..139107) Arthrobacter arilaitensis Re117 9796041 YP_003915344.1 CDS AARI_01340 NC_014550.1 139166 140137 R activator of Hsp90 ATPase 1-like protein complement(139166..140137) Arthrobacter arilaitensis Re117 9796042 YP_003915345.1 CDS AARI_01350 NC_014550.1 140149 140487 R identified by match to PF01022. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator complement(140149..140487) Arthrobacter arilaitensis Re117 9796043 YP_003915346.1 CDS AARI_01360 NC_014550.1 140708 141928 D transcriptional regulator 140708..141928 Arthrobacter arilaitensis Re117 9796044 YP_003915347.1 CDS AARI_01370 NC_014550.1 142094 143617 D catalyses the following reaction: an aldehyde + NAD(+) + H(2)O <=> an acid + NADH; aldehyde dehydrogenase 142094..143617 Arthrobacter arilaitensis Re117 9796045 YP_003915348.1 CDS AARI_01380 NC_014550.1 143767 144798 D catalyses the following reaction: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH; Zn-dependent alcohol dehydrogenase 143767..144798 Arthrobacter arilaitensis Re117 9796046 YP_003915349.1 CDS AARI_01390 NC_014550.1 144967 145392 D hypothetical protein 144967..145392 Arthrobacter arilaitensis Re117 9796047 YP_003915350.1 CDS uveA NC_014550.1 145402 145854 D identified by similarity to protein SP:P94957 (Micrococcus luteus). It is a DNA excision repair enzyme. Also named UV endonuclease (cyclobutane pyrimidine dimer- DNA glycosylase/abasic lyase); pyrimidine dimer DNA glycosylase 145402..145854 Arthrobacter arilaitensis Re117 9796048 YP_003915351.1 CDS ddh NC_014550.1 145875 146858 R catalyses the following reaction: L-2-amino-6- oxoheptanedioate + NH(3) + NADPH <=> meso-2,6- diaminoheptanedioate + H(2)O + NADP(+). Involved in lysine biosynthesis; diaminopimelate dehydrogenase complement(145875..146858) Arthrobacter arilaitensis Re117 9794494 YP_003915352.1 CDS AARI_01420 NC_014550.1 146972 147130 R hypothetical protein complement(146972..147130) Arthrobacter arilaitensis Re117 9793797 YP_003915353.1 CDS AARI_01430 NC_014550.1 147158 147439 R hypothetical protein complement(147158..147439) Arthrobacter arilaitensis Re117 9796049 YP_003915354.1 CDS trx NC_014550.1 147436 147786 R serves as a general protein disulphide oxidoreductase. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of 2 cysteine thiol groups to a disulphide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulphide and a dithiol; thioredoxin complement(147436..147786) Arthrobacter arilaitensis Re117 9796050 YP_003915355.1 CDS AARI_01450 NC_014550.1 147786 148652 R 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(147786..148652) Arthrobacter arilaitensis Re117 9794478 YP_003915356.1 CDS AARI_01460 NC_014550.1 148656 149195 R identified by match to protein domain PF00581. Rhodanese has an internal duplication. This HMM represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases; rhodanese domain-containing protein complement(148656..149195) Arthrobacter arilaitensis Re117 9796051 YP_003915357.1 CDS AARI_01470 NC_014550.1 149227 150612 R identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase complement(149227..150612) Arthrobacter arilaitensis Re117 9796052 YP_003915358.1 CDS AARI_01480 NC_014550.1 150733 151185 R hypothetical protein complement(150733..151185) Arthrobacter arilaitensis Re117 9796053 YP_003915359.1 CDS AARI_01490 NC_014550.1 151223 151822 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(151223..151822) Arthrobacter arilaitensis Re117 9796054 YP_003915360.1 CDS AARI_01500 NC_014550.1 152015 152365 D identified by match to protein family PF02566: OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress-induced protein found in Escherichia coli. This family also contains an organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation; OsmC-like protein 152015..152365 Arthrobacter arilaitensis Re117 9796055 YP_003915361.1 CDS AARI_01530 NC_014550.1 152924 153577 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(152924..153577) Arthrobacter arilaitensis Re117 9796058 YP_003915362.1 CDS AARI_01540 NC_014550.1 153708 156539 D identified by match to PF02913 and PF01565; FAD linked oxidase domain-containing protein 153708..156539 Arthrobacter arilaitensis Re117 9796059 YP_003915363.1 CDS AARI_01550 NC_014550.1 156622 158082 R identified by match to SM00507; HNH endonuclease domain-containing protein complement(156622..158082) Arthrobacter arilaitensis Re117 9796060 YP_003915364.1 CDS AARI_01560 NC_014550.1 158392 159873 D amino acid-polyamine-organocation (APC) Superfamily (TC 2.A.3.y.z); amino acid transporter 158392..159873 Arthrobacter arilaitensis Re117 9796061 YP_003915365.1 CDS AARI_01570 NC_014550.1 160003 160272 D hypothetical protein 160003..160272 Arthrobacter arilaitensis Re117 9796062 YP_003915366.1 CDS AARI_01580 NC_014550.1 160295 160765 R hypothetical protein complement(160295..160765) Arthrobacter arilaitensis Re117 9796063 YP_003915367.1 CDS gntK NC_014550.1 161722 162171 D gluconokinase catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product, gluconate-6- phoshate, is an important precursor of gluconate metabolism; gluconokinase 161722..162171 Arthrobacter arilaitensis Re117 9796065 YP_003915368.1 CDS AARI_01610 NC_014550.1 162264 162428 D hypothetical protein 162264..162428 Arthrobacter arilaitensis Re117 9793931 YP_003915369.1 CDS AARI_01620 NC_014550.1 162697 164367 D identified by match to protein domain PF00205. Thiamine pyrophosphate binding domains are present in enzymes such as acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase and phosphonopyruvate decarboxylase; thiamine pyrophosphate binding domain-containing protein 162697..164367 Arthrobacter arilaitensis Re117 9796066 YP_003915370.1 CDS AARI_01630 NC_014550.1 164390 165478 D signal peptide predicted by SignalP 3.0 HMM (probability: 1) with cleavage site probability 0.973 between position 26 and 27; hypothetical protein 164390..165478 Arthrobacter arilaitensis Re117 9796067 YP_003915371.1 CDS AARI_01640 NC_014550.1 165475 166776 R FAD-linked oxidoreductase complement(165475..166776) Arthrobacter arilaitensis Re117 9796068 YP_003915372.1 CDS AARI_01650 NC_014550.1 166773 167963 R hypothetical protein complement(166773..167963) Arthrobacter arilaitensis Re117 9796069 YP_003915373.1 CDS AARI_01660 NC_014550.1 168077 168841 D hypothetical protein 168077..168841 Arthrobacter arilaitensis Re117 9796070 YP_003915374.1 CDS AARI_01670 NC_014550.1 175227 175784 D match to protein domain PF01872. This domain is found in the C-terminus of the bifunctional deaminase- reductase in combination with PF00383 as well as in isolation in some archaebacterial proteins; RibD domain-containing protein 175227..175784 Arthrobacter arilaitensis Re117 9793576 YP_003915375.1 CDS mtlK NC_014550.1 175843 177330 R mannitol 2-dehydrogenase catalyzes the NAD- dependent reduction of mannitol to fructose; mannitol 2-dehydrogenase complement(175843..177330) Arthrobacter arilaitensis Re117 9796072 YP_003915376.1 CDS AARI_01690 NC_014550.1 177368 178693 R major facilitator superfamily, polyol porter (PP) family (TC 2.A.1.18.z). Possible mannitol transporter; polyol transporter complement(177368..178693) Arthrobacter arilaitensis Re117 9794113 YP_003915377.1 CDS AARI_01700 NC_014550.1 178833 179669 D DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-like regulators are generally phosphorylated intermediates of the relevant metabolic pathway; DeoR family transcriptional regulator 178833..179669 Arthrobacter arilaitensis Re117 9796073 YP_003915378.1 CDS xylB NC_014550.1 179666 181054 D catalyses the following reaction: ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate. Involved in the catabolism of xylose; xylulokinase 179666..181054 Arthrobacter arilaitensis Re117 9796074 YP_003915379.1 CDS glpQ NC_014550.1 181081 181950 D glycerophosphoryl diester phosphodiesterases display broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol); glycerophosphodiester phosphodiesterase 181081..181950 Arthrobacter arilaitensis Re117 9794513 YP_003915380.1 CDS AARI_01730 NC_014550.1 181956 182639 D hypothetical protein 181956..182639 Arthrobacter arilaitensis Re117 9793913 YP_003915381.1 CDS AARI_01740 NC_014550.1 182662 183351 D identified by match to protein family PF03591; AzlC family protein 182662..183351 Arthrobacter arilaitensis Re117 9796075 YP_003915382.1 CDS AARI_01750 NC_014550.1 183348 183665 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 183348..183665 Arthrobacter arilaitensis Re117 9796076 YP_003915383.1 CDS AARI_01760 NC_014550.1 183718 184038 D hypothetical protein 183718..184038 Arthrobacter arilaitensis Re117 9796077 YP_003915384.1 CDS AARI_01770 NC_014550.1 184035 184724 D match to PF01596. This family includes catechol o- methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production; O-methyltransferase 184035..184724 Arthrobacter arilaitensis Re117 9796078 YP_003915385.1 CDS AARI_01780 NC_014550.1 184729 185082 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(184729..185082) Arthrobacter arilaitensis Re117 9796079 YP_003915386.1 CDS AARI_01790 NC_014550.1 185251 185766 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 185251..185766 Arthrobacter arilaitensis Re117 9796080 YP_003915387.1 CDS AARI_01800 NC_014550.1 185783 186586 D hypothetical protein 185783..186586 Arthrobacter arilaitensis Re117 9796081 YP_003915388.1 CDS AARI_01810 NC_014550.1 186583 187092 R hypothetical protein complement(186583..187092) Arthrobacter arilaitensis Re117 9796082 YP_003915389.1 CDS AARI_01820 NC_014550.1 187183 188634 R major facilitator superfamily, AzgA family purine transporter (TC 2.A.1.40.z); purine transporter complement(187183..188634) Arthrobacter arilaitensis Re117 9796083 YP_003915390.1 CDS AARI_01830 NC_014550.1 188804 189781 D identified by match to PF00582: universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general stress endurance activity; universal stress family domain-containing protein 188804..189781 Arthrobacter arilaitensis Re117 9796084 YP_003915391.1 CDS AARI_01840 NC_014550.1 189859 191556 R Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.432 between position 29 and 30; hypothetical protein complement(189859..191556) Arthrobacter arilaitensis Re117 9796085 YP_003915392.1 CDS AARI_01850 NC_014550.1 192227 192598 R match to PS00142 pattern: neutral zinc metallopeptidases, zinc-binding region signature; hypothetical protein complement(192227..192598) Arthrobacter arilaitensis Re117 9796086 YP_003915393.1 CDS AARI_01860 NC_014550.1 193247 194101 R hypothetical protein complement(193247..194101) Arthrobacter arilaitensis Re117 9793580 YP_003915394.1 CDS xthA NC_014550.1 194104 194904 R removes the damaged DNA at cytosines and guanines by cleaving on the 3 -side of the apurinic/apyrimidinic sites; exodeoxyribonuclease III complement(194104..194904) Arthrobacter arilaitensis Re117 9796088 YP_003915395.1 CDS AARI_01880 NC_014550.1 195010 196062 D enoyl-CoA hydratase catalyzes the hydratation of 2- trans-enoyl-CoA into 3-hydroxyacyl-CoA; enoyl-CoA hydratase 195010..196062 Arthrobacter arilaitensis Re117 9794511 YP_003915396.1 CDS mmsB NC_014550.1 196059 196955 D catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate. Involved in the catabolism of valine; 3-hydroxyisobutyrate dehydrogenase 196059..196955 Arthrobacter arilaitensis Re117 9796089 YP_003915397.1 CDS AARI_01900 NC_014550.1 196950 197453 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(196950..197453) Arthrobacter arilaitensis Re117 9794083 YP_003915398.1 CDS AARI_01910 NC_014550.1 197710 197913 D hypothetical protein 197710..197913 Arthrobacter arilaitensis Re117 9796090 YP_003915399.1 CDS AARI_01920 NC_014550.1 197910 198350 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 197910..198350 Arthrobacter arilaitensis Re117 9796091 YP_003915400.1 CDS AARI_01930 NC_014550.1 198347 198646 D identified by match to PF01022: bacterial regulatory protein, ArsR family. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator 198347..198646 Arthrobacter arilaitensis Re117 9796092 YP_003915401.1 CDS nadE NC_014550.1 198650 199474 R catalyses the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide; NAD(+) synthase complement(198650..199474) Arthrobacter arilaitensis Re117 9796093 YP_003915402.1 CDS AARI_01950 NC_014550.1 199568 200005 R hypothetical protein complement(199568..200005) Arthrobacter arilaitensis Re117 9794130 YP_003915403.1 CDS pyrE NC_014550.1 200045 200602 D catalyses the formation of orotidine-5-phosphate from orotate and PRPP. Involved in pyrimidine biosynthesis; orotate phosphoribosyltransferase 200045..200602 Arthrobacter arilaitensis Re117 9796094 YP_003915404.1 CDS AARI_01970 NC_014550.1 200672 201742 R match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator complement(200672..201742) Arthrobacter arilaitensis Re117 9794270 YP_003915405.1 CDS bxlE NC_014550.1 201959 203263 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family, xylobiose porter (TC 3.A.1.1.21). ABCISSE: ABC transporter, binding protein (BP), OSP-family (oligosaccharides or polyols); xylobiose ABC transporter substrate-binding protein BxlE 201959..203263 Arthrobacter arilaitensis Re117 9796095 YP_003915406.1 CDS bxlF NC_014550.1 203272 204312 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family, xylobiose porter (TC 3.A.1.1.21). ABCISSE: ABC transporter, permease (IM), OSP-family (oligosaccharides or polyols); xylobiose ABC transporter inner membrane subunit BxlF 203272..204312 Arthrobacter arilaitensis Re117 9793722 YP_003915407.1 CDS bxlG NC_014550.1 204309 205196 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family, xylobiose porter (TC 3.A.1.1.21). ABCISSE: ABC transporter, permease (IM), OSP-family (oligosaccharides or polyols); xylobiose ABC transporter inner membrane subunit BxlG 204309..205196 Arthrobacter arilaitensis Re117 9793723 YP_003915408.1 CDS bxlA NC_014550.1 205244 207574 D hydrolysis of 1,4-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini. Also hydrolyzes xylobiose. Identified by similarity to protein SP: Q76BU6 (Streptomyces thermoviolaceus), involved in degradation of xylans; xylan 1,4-beta-xylosidase 205244..207574 Arthrobacter arilaitensis Re117 9793724 YP_003915409.1 CDS AARI_02020 NC_014550.1 207578 209086 R TCDB: ATP-binding cassette (ABC) superfamily (TC 3. A.1.y.z), DRI-family. Inverted organization, in which the permease component (IM) is C-terminal with respect to the ABC domain (ABC-IM); ABC transporter ATPase and permease components complement(207578..209086) Arthrobacter arilaitensis Re117 9793721 YP_003915410.1 CDS AARI_02030 NC_014550.1 209122 209760 R transcriptional regulator complement(209122..209760) Arthrobacter arilaitensis Re117 9796096 YP_003915411.1 CDS nagD NC_014550.1 209840 210622 R in E. coli, NagD is shown to be a nucleotide phosphatase. Its exact function has not been established, but it play a role in cell wall construction or disassembly (N-acetyl-glucosamine metabolism) or involved in NDP / NMP hydrolysis; NagD-like protein complement(209840..210622) Arthrobacter arilaitensis Re117 9796097 YP_003915412.1 CDS AARI_02050 NC_014550.1 210821 211477 D identified by match to protein family PF00588: SpoU rRNA Methylase family. Possible role in rRNA modification; RNA methyltransferase 210821..211477 Arthrobacter arilaitensis Re117 9794132 YP_003915413.1 CDS AARI_02060 NC_014550.1 211589 212998 D identified by match to protein family PF01551. Members of this family are zinc metallopeptidases with a range of specificities. Peptidase family M23 are also endopeptidases. 1 transmembrane helice predicted by TMHMM2. 0; peptidase M23 211589..212998 Arthrobacter arilaitensis Re117 9796098 YP_003915414.1 CDS fba NC_014550.1 213195 214217 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 213195..214217 Arthrobacter arilaitensis Re117 9796099 YP_003915415.1 CDS AARI_02080 NC_014550.1 214220 214636 D hypothetical protein 214220..214636 Arthrobacter arilaitensis Re117 9793845 YP_003915416.1 CDS AARI_02090 NC_014550.1 214921 215589 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 214921..215589 Arthrobacter arilaitensis Re117 9796100 YP_003915417.1 CDS AARI_02100 NC_014550.1 215589 216407 D hypothetical protein 215589..216407 Arthrobacter arilaitensis Re117 9796101 YP_003915418.1 CDS AARI_02110 NC_014550.1 216424 217092 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(216424..217092) Arthrobacter arilaitensis Re117 9796102 YP_003915419.1 CDS AARI_02120 NC_014550.1 217089 218483 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(217089..218483) Arthrobacter arilaitensis Re117 9796103 YP_003915420.1 CDS AARI_02130 NC_014550.1 218530 218994 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.998) with cleavage site probability 0.527 between position 29 and 30; hypothetical protein complement(218530..218994) Arthrobacter arilaitensis Re117 9796104 YP_003915421.1 CDS AARI_02140 NC_014550.1 219066 219515 R identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator complement(219066..219515) Arthrobacter arilaitensis Re117 9796105 YP_003915422.1 CDS kynU NC_014550.1 219681 220961 D identified by match to protein family PTHR14084. Kynureninase catalyzes the hydrolytic cleavage of L- kynurenine to anthranilic acid and L-alanine. Kynurinine is a Trp breakdown product and a precursor for NAD. This reaction is a key step in the catabolism of L-tryptophan by Pseudomonas fluorescens and some other bacteria; kynureninase 219681..220961 Arthrobacter arilaitensis Re117 9796106 YP_003915423.1 CDS AARI_02160 NC_014550.1 221085 222467 D amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family (TC 2.A.3.1.z); amino acid transporter 221085..222467 Arthrobacter arilaitensis Re117 9794027 YP_003915424.1 CDS tdk NC_014550.1 222573 223196 D catalyzes the formation of thymidine 5-phosphate from thymidine; thymidine kinase 222573..223196 Arthrobacter arilaitensis Re117 9796107 YP_003915425.1 CDS AARI_02180 NC_014550.1 223193 223726 R identified by match to PF00440: bacterial regulatory proteins, tetR family; TetR family transcriptional regulator complement(223193..223726) Arthrobacter arilaitensis Re117 9794435 YP_003915426.1 CDS AARI_02190 NC_014550.1 223760 225028 R xylitol oxidase catalyzes the following reaction: xylitol + O(2) <=> xylose + H(2)O(2); xylitol oxidase complement(223760..225028) Arthrobacter arilaitensis Re117 9796108 YP_003915427.1 CDS xylB NC_014550.1 225038 226465 R catalyses the following reaction: ATP + D-xylulose <=> ADP + D-xylulose 5-phosphate. Involved in the catabolism of xylose; xylulokinase complement(225038..226465) Arthrobacter arilaitensis Re117 9796109 YP_003915428.1 CDS xylA NC_014550.1 226506 227693 R catalyzes the interconversion of D-xylose to D- xylulose. It can also isomerize D-ribose to D-ribulose and D-glucose to D-fructose; xylose isomerase complement(226506..227693) Arthrobacter arilaitensis Re117 9794514 YP_003915429.1 CDS xylR NC_014550.1 227825 229060 D match to PF00480: ROK family; xylose operon repressor 227825..229060 Arthrobacter arilaitensis Re117 9794512 YP_003915430.1 CDS AARI_02230 NC_014550.1 229057 229854 R identified by match to PF00376. Members of the family include the mercuric resistance operon regulatory protein merR; Bacillus subtilis bltR and bmrR; Bacillus glnR; Streptomyces coelicolor hspR; Bradyrhizobium japonicum nolA; Escherichia coli superoxide response regulator soxR; and Streptomyces lividans transcriptional activator tipA; MerR family transcriptional regulator complement(229057..229854) Arthrobacter arilaitensis Re117 9794515 YP_003915431.1 CDS purA NC_014550.1 230117 231406 D catalyzes the first step in the conversion of IMP to AMP in de novo purine nucleotide metabolism; adenylosuccinate synthetase 230117..231406 Arthrobacter arilaitensis Re117 9796191 YP_003915432.1 CDS AARI_02260 NC_014550.1 232196 233851 D PRK08199: acetolactate synthase 2 catalytic subunit; acetolactate synthase large subunit 232196..233851 Arthrobacter arilaitensis Re117 9796192 YP_003915433.1 CDS AARI_34380 NC_014550.1 234175 235116 R transposase of ISAar44, IS3 family, IS3 group, orfB complement(234175..235116) Arthrobacter arilaitensis Re117 9796193 YP_003915434.1 CDS AARI_34390 NC_014550.1 235215 235652 R transposase of ISAar44, IS3 family, IS3 group, orfA complement(235215..235652) Arthrobacter arilaitensis Re117 9797140 YP_003915435.1 CDS AARI_34400 NC_014550.1 236585 236878 D transposase of ISAar37, IS3 family, IS3 group, orfA 236585..236878 Arthrobacter arilaitensis Re117 9796194 YP_003915436.1 CDS AARI_34410 NC_014550.1 236773 237795 D transposase of ISAar37, IS3 family, IS3 group, orfB 236773..237795 Arthrobacter arilaitensis Re117 9797142 YP_003915437.1 CDS AARI_02290 NC_014550.1 238986 239363 D hypothetical protein 238986..239363 Arthrobacter arilaitensis Re117 9796195 YP_003915438.1 CDS AARI_02300 NC_014550.1 239478 239909 D hypothetical protein 239478..239909 Arthrobacter arilaitensis Re117 9796196 YP_003915439.1 CDS tetV NC_014550.1 240509 241813 R major facilitator superfamily (MFS), drug:H+ antiporter-3 (12 spanner) (DHA3) family, tetracycline resistance determinant TetV (TC 2.A.1.21.3). Identified by similarity to protein SP:O31137 (Mycobacterium smegmatis). Probable drug antiporter which uses the proton motive force for the active efflux of tetracycline; tetracycline-resistance determinant TetV complement(240509..241813) Arthrobacter arilaitensis Re117 9796198 YP_003915440.1 CDS AARI_34420 NC_014550.1 242256 243563 D transposase of ISAar23, ISL3 family 242256..243563 Arthrobacter arilaitensis Re117 9794437 YP_003915441.1 CDS ptsI NC_014550.1 243730 245412 R phosphotransferase system enzyme I (EI) Family (TC 8.A.7.y.z). Enzyme I of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate transport system in bacteria. The PTS catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; phosphoenolpyruvate--protein phosphotransferase complement(243730..245412) Arthrobacter arilaitensis Re117 9797144 YP_003915442.1 CDS fruK NC_014550.1 247409 248386 R catalyzes the phosphorylation of fructose-1- phosphate to fructose-1,6-biphosphate. Involved in the catabolism of fructose; 1-phosphofructokinase complement(247409..248386) Arthrobacter arilaitensis Re117 9796199 YP_003915443.1 CDS AARI_02360 NC_014550.1 248383 249159 R DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-like regulators are generally phosphorylated intermediates of the relevant metabolic pathway; DeoR family transcriptional regulator complement(248383..249159) Arthrobacter arilaitensis Re117 9793863 YP_003915444.1 CDS AARI_02370 NC_014550.1 249527 250525 R identified by match to protein family PF02517: CAAX amino terminal protease family. Members of this family are probably proteases (after a prenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein, the AAX tripeptide is removed by one of the CAAX prenyl proteases). The family contains the Q03530 CAAX prenyl protease. 8 transmembrane helices predicted by TMHMM2.0; CAAX amino terminal protease complement(249527..250525) Arthrobacter arilaitensis Re117 9796200 YP_003915445.1 CDS AARI_02380 NC_014550.1 250547 251188 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(250547..251188) Arthrobacter arilaitensis Re117 9796201 YP_003915446.1 CDS AARI_02390 NC_014550.1 251279 251899 D identified by match to PF00440: bacterial regulatory proteins, tetR family; TetR family transcriptional regulator 251279..251899 Arthrobacter arilaitensis Re117 9796202 YP_003915447.1 CDS AARI_02410 NC_014550.1 253139 253318 D hypothetical protein 253139..253318 Arthrobacter arilaitensis Re117 9796204 YP_003915448.1 CDS AARI_34430 NC_014550.1 253766 255073 R transposase of ISAar23, ISL3 family complement(253766..255073) Arthrobacter arilaitensis Re117 9796205 YP_003915449.1 CDS AARI_02420 NC_014550.1 255193 255729 R hypothetical protein complement(255193..255729) Arthrobacter arilaitensis Re117 9797145 YP_003915450.1 CDS AARI_02430 NC_014550.1 256982 257416 D hypothetical protein 256982..257416 Arthrobacter arilaitensis Re117 9796206 YP_003915451.1 CDS AARI_02440 NC_014550.1 257496 257723 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(257496..257723) Arthrobacter arilaitensis Re117 9796207 YP_003915452.1 CDS AARI_02450 NC_014550.1 258309 258803 R CoA-binding domain-containing protein complement(258309..258803) Arthrobacter arilaitensis Re117 9796208 YP_003915453.1 CDS AARI_02460 NC_014550.1 258803 260176 R catalyses several reactions, including the formation of L-homocysteine from O-acetyl-L-homoserine and H2S, and the formation of L-methionine from O-acetyl-L- homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase complement(258803..260176) Arthrobacter arilaitensis Re117 9796209 YP_003915454.1 CDS AARI_02470 NC_014550.1 260498 261058 D identified by match to protein domain PF00300; phosphoglycerate mutase family protein 260498..261058 Arthrobacter arilaitensis Re117 9796210 YP_003915455.1 CDS AARI_02480 NC_014550.1 261179 261676 D match to protein family TIGR02937. Sigma-70 family; RNA polymerase sigma factor 261179..261676 Arthrobacter arilaitensis Re117 9796211 YP_003915456.1 CDS ogt NC_014550.1 261673 262299 D involved in the repair of alkylated DNA; methylated-DNA--[protein]-cysteine S-methyltransferase 261673..262299 Arthrobacter arilaitensis Re117 9796212 YP_003915457.1 CDS AARI_02500 NC_014550.1 262397 264577 R haem-containing catalase-peroxidases are bifunctional antioxidant enzymes that exhibit both catalase and broad-spectrum peroxidase activities, depending on the steady-state concentration of hydrogen peroxide; peroxidase/catalase complement(262397..264577) Arthrobacter arilaitensis Re117 9794156 YP_003915458.1 CDS fur NC_014550.1 264680 265108 R acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Match to protein family PF01475; ferric uptake regulation protein complement(264680..265108) Arthrobacter arilaitensis Re117 9796213 YP_003915459.1 CDS AARI_02520 NC_014550.1 266135 267661 D betaine/carnitine/choline fransporter (BCCT) family (TC 2.A.15.y.z); betaine/carnitine/choline transporter 266135..267661 Arthrobacter arilaitensis Re117 9793873 YP_003915460.1 CDS acsA NC_014550.1 267727 269688 R catalyzes the formation of acetyl-CoA from acetate and CoA; acetate--CoA ligase complement(267727..269688) Arthrobacter arilaitensis Re117 9796214 YP_003915461.1 CDS ssuC NC_014550.1 269753 270580 R TCDB: ATP-binding cassette (ABC) superfamily, taurine uptake transporter (TauT) family (TC3.A.1.17). ABCISSE: ABC transporter, permease (IM), OTCN-family (osmoprotectants, taurine, cyanate and nitrate), aliphatic sulfonates import. Part of the ABC transporter complex ssuABC involved in aliphatic sulfonates import. Is also involved in taurine transport; aliphatic sulfonates ABC transporter inner membrane subunit SsuC complement(269753..270580) Arthrobacter arilaitensis Re117 9793654 YP_003915462.1 CDS ssuA NC_014550.1 270587 271609 R TCDB: ATP-binding cassette (ABC) superfamily, taurine uptake transporter (TauT) family (TC 3.A.1.17.z). ABCISSE: ABC transporter, permease (IM), OTCN-family (osmoprotectants, taurine, cyanate and nitrate), aliphatic sulfonates import. Part of the ABC transporter complex ssuABC involved in aliphatic sulfonates import; aliphatic sulfonates ABC transporter substrate-binding protein SsuA complement(270587..271609) Arthrobacter arilaitensis Re117 9794408 YP_003915463.1 CDS ssuB NC_014550.1 271695 272516 R TCDB: ATP-binding cassette (ABC) superfamily, taurine uptake transporter (TauT) family (TC 3.A.1.17.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OTCN- family (osmoprotectants, taurine, cyanate and nitrate), aliphatic sulfonates import. Part of the ABC transporter complex ssuABC involved in aliphatic sulfonates import; aliphatic sulfonates ABC transporter ATP-binding subunit SsuB complement(271695..272516) Arthrobacter arilaitensis Re117 9794406 YP_003915464.1 CDS AARI_02570 NC_014550.1 272997 274328 D possibly involved in the metabolism of lipids. Match to PF08028. Acyl-CoA dehydrogenases catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase 272997..274328 Arthrobacter arilaitensis Re117 9794407 YP_003915465.1 CDS AARI_02580 NC_014550.1 274382 275785 D possibly involved in the metabolism of lipids. Identified by match to PF00296. Bacterial luciferase is a flavin monooxygenase that catalyses the oxidation of long- chain aldehydes and releases energy in the form of visible light, and which uses flavin as a substrate rather than a cofactor. There are structural similarities between bacterial luciferase and nonfluorescent flavoproteins (LuxF, FP390), alkanesulfonate monooxygenase (SsuD), and coenzyme F420-dependent terahydromethanopterin reductase, which make up clearly related families with somewhat different folds; luciferase-like monooxygenase 274382..275785 Arthrobacter arilaitensis Re117 9796215 YP_003915466.1 CDS ggt NC_014550.1 275862 277685 R catalyzes the transfer of the gamma-glutamyl moiety of glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate); gamma-glutamyltransferase complement(275862..277685) Arthrobacter arilaitensis Re117 9796216 YP_003915467.1 CDS AARI_02600 NC_014550.1 277900 278763 R hypothetical protein complement(277900..278763) Arthrobacter arilaitensis Re117 9793897 YP_003915468.1 CDS metN NC_014550.1 279257 280276 D TCDB: ATP-binding cassette (ABC) superfamily, methionine uptake transporter (MUT) family (TC 3.A.1.24.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), DLM-family. Part of the ABC transporter complex MetNIQ involved in methionine import. The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ); methionine ABC transporter ATP-binding subunit MetN 279257..280276 Arthrobacter arilaitensis Re117 9796217 YP_003915469.1 CDS metI NC_014550.1 280273 280968 D TCDB: ATP-binding cassette (ABC) superfamily, methionine uptake transporter (MUT) family (TC 3.A.1.24.z). ABCISSE: ABC transporter, permease (IM), DLM- family. Part of the ABC transporter complex MetNIQ involved in methionine import. The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ); methionine ABC transporter inner membrane subunit MetI 280273..280968 Arthrobacter arilaitensis Re117 9794075 YP_003915470.1 CDS metQ NC_014550.1 280998 281909 D TCDB: ATP-binding cassette (ABC) superfamily, methionine uptake transporter (MUT) family (TC 3.A.1.24.z). ABCISSE: ABC transporter, lipoprotein (LPP), DLM-family. Part of the ABC transporter complex metNIQ involved in methionine import. The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ); methionine ABC transporter substrate-binding protein MetQ 280998..281909 Arthrobacter arilaitensis Re117 9794072 YP_003915471.1 CDS AARI_02640 NC_014550.1 282353 284050 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein 282353..284050 Arthrobacter arilaitensis Re117 9794077 YP_003915472.1 CDS AARI_02650 NC_014550.1 284062 285018 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 284062..285018 Arthrobacter arilaitensis Re117 9796218 YP_003915473.1 CDS AARI_02660 NC_014550.1 285033 285920 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 285033..285920 Arthrobacter arilaitensis Re117 9796219 YP_003915474.1 CDS AARI_02670 NC_014550.1 285949 287571 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, fused ATP-binding protein (ABC2), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit 285949..287571 Arthrobacter arilaitensis Re117 9796220 YP_003915475.1 CDS AARI_02680 NC_014550.1 287610 288851 D possibly involved in the metabolism of lipids. Match to PF08028. Acyl-CoA dehydrogenases catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase 287610..288851 Arthrobacter arilaitensis Re117 9796221 YP_003915476.1 CDS AARI_02690 NC_014550.1 288854 290272 D possibly involved in the metabolism of lipids. Identified by match to PF00296. Bacterial luciferase is a flavin monooxygenase that catalyses the oxidation of long- chain aldehydes and releases energy in the form of visible light, and which uses flavin as a substrate rather than a cofactor. There are structural similarities between bacterial luciferase and nonfluorescent flavoproteins (LuxF, FP390), alkanesulfonate monooxygenase (SsuD), and coenzyme F420-dependent terahydromethanopterin reductase, which make up clearly related families with somewhat different folds; luciferase-like monooxygenase 288854..290272 Arthrobacter arilaitensis Re117 9796222 YP_003915477.1 CDS AARI_02710 NC_014550.1 291018 294218 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.987) with cleavage site probability 0.986 between position 61 and 62. 1 transmembrane helice predicted by TMHMM2.0 after the signal peptide; hypothetical protein 291018..294218 Arthrobacter arilaitensis Re117 9796224 YP_003915478.1 CDS fimA NC_014550.1 294172 295839 D identified by similarity to protein SP:O68212 (Actinomyces naeslundii). Fimbriae mediate bacterial adhesion. C-terminal Gram positive anchor (PF00746); fimbrial structural subunit 294172..295839 Arthrobacter arilaitensis Re117 9796225 YP_003915479.1 CDS AARI_02730 NC_014550.1 295970 296908 D identified by match to protein family PF04203. Sortase is a transpeptidase that attaches surface proteins by the threonine of an LPXTG motif to the cell wall. Possible role in synthesis of functional type 2 fimbriae; sortase 295970..296908 Arthrobacter arilaitensis Re117 9793850 YP_003915480.1 CDS AARI_02740 NC_014550.1 296956 297372 D hypothetical protein 296956..297372 Arthrobacter arilaitensis Re117 9796226 YP_003915481.1 CDS AARI_02750 NC_014550.1 297377 297700 D hypothetical protein 297377..297700 Arthrobacter arilaitensis Re117 9796227 YP_003915482.1 CDS AARI_02760 NC_014550.1 297933 298043 D hypothetical protein 297933..298043 Arthrobacter arilaitensis Re117 9796228 YP_003915483.1 CDS AARI_34440 NC_014550.1 298139 299575 D transposase of ISAar8, IS1380 family 298139..299575 Arthrobacter arilaitensis Re117 9796229 YP_003915484.1 CDS AARI_02770 NC_014550.1 299740 301776 R 5 -nucleotidases are enzymes that catalyze the hydrolysis of phosphate esterified at carbon 5 of the ribose and deoxyribose portions of nucleotide molecules; 5'-nucleotidase complement(299740..301776) Arthrobacter arilaitensis Re117 9797146 YP_003915485.1 CDS AARI_02780 NC_014550.1 301894 302091 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(301894..302091) Arthrobacter arilaitensis Re117 9796230 YP_003915486.1 CDS AARI_02790 NC_014550.1 302283 302984 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.992 between position 38 and 39; hypothetical protein complement(302283..302984) Arthrobacter arilaitensis Re117 9796231 YP_003915487.1 CDS AARI_02800 NC_014550.1 303239 303493 D hypothetical protein 303239..303493 Arthrobacter arilaitensis Re117 9796232 YP_003915488.1 CDS fabG NC_014550.1 303870 304676 D 3-oxoacyl-ACP reductase catalyses the following reaction: (3R)-3-hydroxyacyl-[acyl- carrier-protein] + NADP(+) <=> 3-oxoacyl-[acyl-carrier- protein] + NADPH. It is involved in fatty acid biosynthesis; 3-oxoacyl-ACP reductase 303870..304676 Arthrobacter arilaitensis Re117 9796233 YP_003915489.1 CDS AARI_02820 NC_014550.1 304673 306019 D monooxygenase 304673..306019 Arthrobacter arilaitensis Re117 9793838 YP_003915490.1 CDS AARI_02830 NC_014550.1 305960 307309 R possibly involved in the intracellular release of iron from iron-siderophore complexes; enterochelin esterase-like protein complement(305960..307309) Arthrobacter arilaitensis Re117 9796234 YP_003915491.1 CDS AARI_02840 NC_014550.1 307299 308183 R identified by match to protein family PF04954. Match to protein domain PF08021. Possibly involved in removal of iron from iron-siderophore complexes; siderophore-interacting protein complement(307299..308183) Arthrobacter arilaitensis Re117 9796235 YP_003915492.1 CDS AARI_02850 NC_014550.1 308216 309235 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(308216..309235) Arthrobacter arilaitensis Re117 9796236 YP_003915493.1 CDS AARI_02860 NC_014550.1 309232 310251 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(309232..310251) Arthrobacter arilaitensis Re117 9796237 YP_003915494.1 CDS AARI_02870 NC_014550.1 310274 311296 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(310274..311296) Arthrobacter arilaitensis Re117 9796238 YP_003915495.1 CDS AARI_02880 NC_014550.1 311493 312878 R identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family; AraC family transcriptional regulator complement(311493..312878) Arthrobacter arilaitensis Re117 9796239 YP_003915496.1 CDS AARI_02890 NC_014550.1 312868 312978 R hypothetical protein complement(312868..312978) Arthrobacter arilaitensis Re117 9796240 YP_003915497.1 CDS AARI_02900 NC_014550.1 313047 314282 R identified by match to protein family PF04954. Match to protein domain PF08021. Possibly involved in removal of iron from iron-siderophore complexes; siderophore-interacting protein complement(313047..314282) Arthrobacter arilaitensis Re117 9796241 YP_003915498.1 CDS AARI_02910 NC_014550.1 314485 314832 D identified by match to PF08274 and PF03831. This protein family includes an uncharacterised member designated PhnA in Escherichia coli, part of a large operon associated with alkylphosphonate uptake and carbon- phosphorus bond cleavage (alkylphosphonates utilization as phosphorus source); PhnA protein 314485..314832 Arthrobacter arilaitensis Re117 9796242 YP_003915499.1 CDS AARI_02920 NC_014550.1 314988 315602 D hypothetical protein 314988..315602 Arthrobacter arilaitensis Re117 9796243 YP_003915500.1 CDS purL NC_014550.1 315664 317979 R phosphoribosylformylglycinamidine synthase catalyzes the fourth step in the de novo biosynthesis of purines. In Bacillus subtilis it is formed from three proteins: PurS, PurQ and smPurL; phosphoribosylformylglycinamidine synthase subunit L complement(315664..317979) Arthrobacter arilaitensis Re117 9796244 YP_003915501.1 CDS purQ NC_014550.1 317976 318728 R phosphoribosylformylglycinamidine synthase catalyzes the fourth step in the de novo biosynthesis of purines. In Bacillus subtilis it is formed from three proteins: PurS, PurQ and smPurL; phosphoribosylformylglycinamidine synthase subunit PurQ complement(317976..318728) Arthrobacter arilaitensis Re117 9794252 YP_003915502.1 CDS purS NC_014550.1 318728 318979 R phosphoribosylformylglycinamidine synthase catalyzes the fourth step in the de novo biosynthesis of purines. In Bacillus subtilis it is formed from three proteins: PurS, PurQ and smPurL; phosphoribosylformylglycinamidine synthase subunit PurS complement(318728..318979) Arthrobacter arilaitensis Re117 9794255 YP_003915503.1 CDS AARI_02960 NC_014550.1 319162 319611 D hypothetical protein 319162..319611 Arthrobacter arilaitensis Re117 9794256 YP_003915504.1 CDS AARI_02970 NC_014550.1 319616 320608 R contains ankyrin repeats (PF0023). Such repeats occur in a large number of functionally diverse proteins mainly from eukaryotes. They have been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers; ankyrin repeat protein complement(319616..320608) Arthrobacter arilaitensis Re117 9796245 YP_003915505.1 CDS rumB NC_014550.1 320786 321916 D catalyzes the formation of 5-methyl-uridine at position 747 (M-5-U747) in 23S rRNA; 23S rRNA (uracil-5-)-methyltransferase RumB 320786..321916 Arthrobacter arilaitensis Re117 9796246 YP_003915506.1 CDS AARI_02990 NC_014550.1 321913 323490 R CPA superfamily, monovalent cation:proton antiporter-1 (CPA1) family (TC 2.A.36.y.z). Na+/H+ antiporters are key transporters in maintaining the pH of actively metabolising cells; Na+/H+ antiporter complement(321913..323490) Arthrobacter arilaitensis Re117 9794370 YP_003915507.1 CDS AARI_03000 NC_014550.1 323538 323969 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.735 between position 34 and 35; hypothetical protein complement(323538..323969) Arthrobacter arilaitensis Re117 9796247 YP_003915508.1 CDS AARI_03010 NC_014550.1 324003 324902 R hypothetical protein complement(324003..324902) Arthrobacter arilaitensis Re117 9796248 YP_003915509.1 CDS AARI_03020 NC_014550.1 324981 325538 D hypothetical protein 324981..325538 Arthrobacter arilaitensis Re117 9796249 YP_003915510.1 CDS AARI_03030 NC_014550.1 325684 327033 D identified by match to protein family PF01370: NAD dependent epimerase/dehydratase family. This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; NAD dependent epimerase/dehydratase family protein 325684..327033 Arthrobacter arilaitensis Re117 9796250 YP_003915511.1 CDS hemH NC_014550.1 327255 328385 D catalyzes the last step in heme biosynthesis: the chelation of a ferrous ion to proto-porphyrin IX, to form protoheme: Protoheme + 2 H+ <=> protoporphyrin + Fe2+; ferrochelatase 327255..328385 Arthrobacter arilaitensis Re117 9796251 YP_003915512.1 CDS AARI_03050 NC_014550.1 328650 328859 D hypothetical protein 328650..328859 Arthrobacter arilaitensis Re117 9793956 YP_003915513.1 CDS citH NC_014550.1 328865 330289 R identified by similarity to protein SP:Q6M8T2 (Corynebacterium glutamicum). IT superfamily, citrate- Mg2+:H+ (CitM) citrate-Ca2+:H+ (CitH) symporter (CitMHS) family (TC 2.A.11.y.z); citrate transporter complement(328865..330289) Arthrobacter arilaitensis Re117 9796252 YP_003915514.1 CDS citB NC_014550.1 332169 332840 D identified by similarity to protein SP:Q8NU70 (Corynebacterium glutamicum). CitAB controls citrate utilization in Corynebacterium glutamicum; two-component system response regulator CitB 332169..332840 Arthrobacter arilaitensis Re117 9796254 YP_003915515.1 CDS AARI_03100 NC_014550.1 332853 333593 R match to PF01636. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase; phosphotransferase complement(332853..333593) Arthrobacter arilaitensis Re117 9793735 YP_003915516.1 CDS AARI_03110 NC_014550.1 333732 335339 D catalyses the following reaction : a phosphate monoester + H(2)O <=> an alcohol + phosphate; alkaline phosphatase 333732..335339 Arthrobacter arilaitensis Re117 9796255 YP_003915517.1 CDS ask NC_014550.1 335410 336696 R catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine; aspartate kinase complement(335410..336696) Arthrobacter arilaitensis Re117 9796256 YP_003915518.1 CDS AARI_03130 NC_014550.1 336878 337429 R hypothetical protein complement(336878..337429) Arthrobacter arilaitensis Re117 9793694 YP_003915519.1 CDS AARI_03140 NC_014550.1 337450 337605 R hypothetical protein complement(337450..337605) Arthrobacter arilaitensis Re117 9796257 YP_003915520.1 CDS AARI_03150 NC_014550.1 337846 338322 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(337846..338322) Arthrobacter arilaitensis Re117 9796258 YP_003915521.1 CDS AARI_03160 NC_014550.1 338331 339953 R major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z). Identified by match to protein family TIGR00711; EmrB/QacA subfamily drug resistance transporter complement(338331..339953) Arthrobacter arilaitensis Re117 9796259 YP_003915522.1 CDS recR NC_014550.1 340137 340949 R may play a role in DNA repair. It seems to be involved in an recBC-independent recombinational process of DNA repair. It may act with recF and recO; recombination protein recR complement(340137..340949) Arthrobacter arilaitensis Re117 9796260 YP_003915523.1 CDS dnaX NC_014550.1 341040 344486 R DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunits gamma and tau complement(341040..344486) Arthrobacter arilaitensis Re117 9794291 YP_003915524.1 CDS AARI_03190 NC_014550.1 344577 345497 R glutamate--tRNA ligase complement(344577..345497) Arthrobacter arilaitensis Re117 9793828 YP_003915525.1 CDS AARI_03200 NC_014550.1 345728 347260 R identified by match to cd00085: HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins; HNH endonuclease complement(345728..347260) Arthrobacter arilaitensis Re117 9796261 YP_003915526.1 CDS AARI_03210 NC_014550.1 347668 348033 D hypothetical protein 347668..348033 Arthrobacter arilaitensis Re117 9793581 YP_003915527.1 CDS AARI_03220 NC_014550.1 348140 349180 R identified by match to PF03171. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)- dependent oxygenase superfamily; 2OG-Fe(II) oxygenase superfamily protein complement(348140..349180) Arthrobacter arilaitensis Re117 9796263 YP_003915528.1 CDS AARI_03230 NC_014550.1 349456 349758 D hypothetical protein 349456..349758 Arthrobacter arilaitensis Re117 9796264 YP_003915529.1 CDS AARI_03240 NC_014550.1 349840 350460 D hypothetical protein 349840..350460 Arthrobacter arilaitensis Re117 9796265 YP_003915530.1 CDS AARI_03250 NC_014550.1 350465 351154 R match to protein domain PF01323; DSBA-like thioredoxin domain-containing protein complement(350465..351154) Arthrobacter arilaitensis Re117 9796266 YP_003915531.1 CDS AARI_03260 NC_014550.1 351220 351999 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 351220..351999 Arthrobacter arilaitensis Re117 9796267 YP_003915532.1 CDS hutT NC_014550.1 352064 353470 R amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family, histidine permease (TC 2.A.3.1.9). Identified by similarity to protein SP:Q9H86 (Pseudomonas aeruginosa); histidine-specific permease complement(352064..353470) Arthrobacter arilaitensis Re117 9796268 YP_003915533.1 CDS AARI_03280 NC_014550.1 353597 354223 D identified by match to protein domain PF00300; phosphoglycerate mutase family protein 353597..354223 Arthrobacter arilaitensis Re117 9793993 YP_003915534.1 CDS AARI_03290 NC_014550.1 354230 355294 R match to PF00561: alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; hydrolase complement(354230..355294) Arthrobacter arilaitensis Re117 9796269 YP_003915535.1 CDS aceB NC_014550.1 355426 357063 R catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate, the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants; malate synthase complement(355426..357063) Arthrobacter arilaitensis Re117 9796270 YP_003915536.1 CDS aceA NC_014550.1 357144 358457 R catalyzes the conversion of isocitrate to succinate and glyoxylate. This is the first step in the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants; isocitrate lyase complement(357144..358457) Arthrobacter arilaitensis Re117 9793648 YP_003915537.1 CDS AARI_03320 NC_014550.1 358984 359586 R hypothetical protein complement(358984..359586) Arthrobacter arilaitensis Re117 9793647 YP_003915538.1 CDS AARI_03330 NC_014550.1 359596 360216 R identified by match to protein domain PF02223. dTMP kinase (thymidylate kinase) catalyzes the phosphorylation of thymidine 5-monophosphate (dTMP) to thymidine 5- diphosphate (dTDP) in the presence of ATP and magnesium; dTMP kinase complement(359596..360216) Arthrobacter arilaitensis Re117 9796271 YP_003915539.1 CDS AARI_03340 NC_014550.1 360294 360392 D hypothetical protein 360294..360392 Arthrobacter arilaitensis Re117 9796353 YP_003915540.1 CDS AARI_03350 NC_014550.1 360453 361916 D match to protein domain PF01381: helix-turn-helix; transcriptional regulator 360453..361916 Arthrobacter arilaitensis Re117 9796354 YP_003915541.1 CDS AARI_03360 NC_014550.1 361927 362589 R hydrolase complement(361927..362589) Arthrobacter arilaitensis Re117 9796355 YP_003915542.1 CDS AARI_03370 NC_014550.1 362644 363543 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.454 between position 41 and 42; hypothetical protein complement(362644..363543) Arthrobacter arilaitensis Re117 9796356 YP_003915543.1 CDS AARI_03380 NC_014550.1 363603 364022 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(363603..364022) Arthrobacter arilaitensis Re117 9796357 YP_003915544.1 CDS AARI_03390 NC_014550.1 364052 364408 R hypothetical protein complement(364052..364408) Arthrobacter arilaitensis Re117 9796358 YP_003915545.1 CDS AARI_03400 NC_014550.1 364496 364993 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(364496..364993) Arthrobacter arilaitensis Re117 9796359 YP_003915546.1 CDS clpC NC_014550.1 365165 367723 R ATP-dependent Clp proteases act as chaperones to target the proteases to substrates; ATP-dependent Clp protease ATP-binding subunit complement(365165..367723) Arthrobacter arilaitensis Re117 9796360 YP_003915547.1 CDS AARI_03420 NC_014550.1 367853 368527 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(367853..368527) Arthrobacter arilaitensis Re117 9793739 YP_003915548.1 CDS AARI_03430 NC_014550.1 368629 368796 D hypothetical protein 368629..368796 Arthrobacter arilaitensis Re117 9796361 YP_003915549.1 CDS AARI_03440 NC_014550.1 368856 370028 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 5 transmembrane helices predicted by TMHMM2.0; signal transduction histidine kinase 368856..370028 Arthrobacter arilaitensis Re117 9796362 YP_003915550.1 CDS AARI_03450 NC_014550.1 370382 371002 D dihydropteridine reductase family protein 370382..371002 Arthrobacter arilaitensis Re117 9796363 YP_003915551.1 CDS AARI_03460 NC_014550.1 371071 372276 R hypothetical protein complement(371071..372276) Arthrobacter arilaitensis Re117 9796364 YP_003915552.1 CDS AARI_03470 NC_014550.1 372582 373877 D catalyzes the following reaction: D-amino acid + H(2)O + acceptor <=> 2-oxo acid + NH(3) + reduced acceptor. Acts to some extent on all D-amino acids except D-aspartate and D-glutamate; D-amino-acid dehydrogenase 372582..373877 Arthrobacter arilaitensis Re117 9796365 YP_003915553.1 CDS AARI_34450 NC_014550.1 374204 375511 D transposase of ISAar23, ISL3 family 374204..375511 Arthrobacter arilaitensis Re117 9796366 YP_003915554.1 CDS AARI_03480 NC_014550.1 375571 376425 R identified by match to protein family PF01370: NAD dependent epimerase/dehydratase family. This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; NAD dependent epimerase/dehydratase family protein complement(375571..376425) Arthrobacter arilaitensis Re117 9797147 YP_003915555.1 CDS AARI_03490 NC_014550.1 376541 377746 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 376541..377746 Arthrobacter arilaitensis Re117 9796367 YP_003915556.1 CDS umuD NC_014550.1 378017 378433 D in Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; DNA polymerase subunit UmuD 378017..378433 Arthrobacter arilaitensis Re117 9796368 YP_003915557.1 CDS umuC NC_014550.1 378423 379715 D in Escherichia coli umuD and umuC genes have been shown to encode E. coli s fifth DNA polymerase, pol V (consisting of a heterotrimer of UmuD (2)C). The main function of pol V appears to be the bypass of DNA lesions that would otherwise block replication by pols I-IV; DNA polymerase subunit UmuC 378423..379715 Arthrobacter arilaitensis Re117 9794488 YP_003915558.1 CDS AARI_03520 NC_014550.1 379788 381107 D identified by match to PF00933. Glycoside hydrolase family 3 comprises enzymes with a number of known activities; beta-glucosidase (EC:3.2.1.21); beta- xylosidase (EC:3.2.1.37); N-acetyl beta-glucosaminidase (EC:3.2.1.52); glucan beta-1,3-glucosidase (EC:3.2.1.58); cellodextrinase (EC:3.2.1.74); exo-1,3-1,4-glucanase (EC:3. 2.1); glycosyl hydrolase family 3 protein 379788..381107 Arthrobacter arilaitensis Re117 9794487 YP_003915559.1 CDS AARI_03530 NC_014550.1 381145 384426 R identified by match to PF00082. Subtilases are a family of serine proteases. The vast majority of the family are endopeptidases. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.964 between position 32 and 33; subtilase complement(381145..384426) Arthrobacter arilaitensis Re117 9796369 YP_003915560.1 CDS AARI_03540 NC_014550.1 384780 385268 R hypothetical protein complement(384780..385268) Arthrobacter arilaitensis Re117 9796370 YP_003915561.1 CDS AARI_34460 NC_014550.1 385681 386958 D transposase of ISAar13, ISL3 family 385681..386958 Arthrobacter arilaitensis Re117 9796371 YP_003915562.1 CDS AARI_03550 NC_014550.1 387055 387876 R EC 2.7.4.7 is involved in thiamin biosynthesis. It catalyzes the phosphorylation of HMP-P to HMP-PP; phosphomethylpyrimidine kinase complement(387055..387876) Arthrobacter arilaitensis Re117 9797148 YP_003915563.1 CDS AARI_03560 NC_014550.1 387918 388532 R hypothetical protein complement(387918..388532) Arthrobacter arilaitensis Re117 9796372 YP_003915564.1 CDS AARI_03570 NC_014550.1 388666 389373 R identified by match to PF00440: bacterial regulatory proteins, tetR family; TetR family transcriptional regulator complement(388666..389373) Arthrobacter arilaitensis Re117 9796373 YP_003915565.1 CDS AARI_03580 NC_014550.1 389732 390442 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 389732..390442 Arthrobacter arilaitensis Re117 9796374 YP_003915566.1 CDS AARI_03590 NC_014550.1 390509 391204 D TCDB: ATP-binding cassette (ABC) superfamily (TC 3. A.1.y.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), DRI-family; ABC transporter ATP-binding subunit 390509..391204 Arthrobacter arilaitensis Re117 9796375 YP_003915567.1 CDS AARI_03600 NC_014550.1 391212 392777 D 12 transmembrane helices predicted by TMHMM2.0; hypothetical protein 391212..392777 Arthrobacter arilaitensis Re117 9796376 YP_003915568.1 CDS AARI_03610 NC_014550.1 392806 393261 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 392806..393261 Arthrobacter arilaitensis Re117 9796377 YP_003915569.1 CDS tgt NC_014550.1 393333 394631 R exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)- 7-deazaguanosine); queuine tRNA-ribosyltransferase complement(393333..394631) Arthrobacter arilaitensis Re117 9796378 YP_003915570.1 CDS AARI_03630 NC_014550.1 394765 395862 D 10 transmembrane helices predicted by TMHMM2.0; hypothetical protein 394765..395862 Arthrobacter arilaitensis Re117 9794438 YP_003915571.1 CDS AARI_03640 NC_014550.1 395859 396398 R hypothetical protein complement(395859..396398) Arthrobacter arilaitensis Re117 9796379 YP_003915572.1 CDS AARI_03650 NC_014550.1 396607 398055 D major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z). Identified by match to protein family TIGR00711; EmrB/QacA subfamily drug resistance transporter 396607..398055 Arthrobacter arilaitensis Re117 9796380 YP_003915573.1 CDS AARI_03660 NC_014550.1 398204 398980 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductase 398204..398980 Arthrobacter arilaitensis Re117 9796381 YP_003915574.1 CDS AARI_03670 NC_014550.1 399005 399421 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(399005..399421) Arthrobacter arilaitensis Re117 9796382 YP_003915575.1 CDS AARI_03680 NC_014550.1 399461 401104 D serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. This protein may be a resolvase (match to PF07508 and PF00239); site-specific recombinase 399461..401104 Arthrobacter arilaitensis Re117 9796383 YP_003915576.1 CDS AARI_03690 NC_014550.1 401281 401850 R hypothetical protein complement(401281..401850) Arthrobacter arilaitensis Re117 9796384 YP_003915577.1 CDS AARI_03700 NC_014550.1 401860 402321 R identified by match to PF00436. The Escherichia coli single-strand binding protein binds tightly to single- stranded DNA (ss-DNA) and plays an important role in DNA replication, recombination and repair. Closely related variants of SSB are encoded in the genome of a variety of large self-transmissible plasmids; single-stranded DNA-binding protein complement(401860..402321) Arthrobacter arilaitensis Re117 9796385 YP_003915578.1 CDS AARI_03710 NC_014550.1 402407 404173 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(402407..404173) Arthrobacter arilaitensis Re117 9796386 YP_003915579.1 CDS AARI_03720 NC_014550.1 404170 404709 R hypothetical protein complement(404170..404709) Arthrobacter arilaitensis Re117 9796387 YP_003915580.1 CDS AARI_03730 NC_014550.1 404706 406262 R hypothetical protein complement(404706..406262) Arthrobacter arilaitensis Re117 9796388 YP_003915581.1 CDS AARI_03740 NC_014550.1 406259 407074 R hypothetical protein complement(406259..407074) Arthrobacter arilaitensis Re117 9796389 YP_003915582.1 CDS AARI_03750 NC_014550.1 407333 409069 D TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-1 (Drug RA1) family (TC 3.A.1.120.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family. Duplicated ATPase domains (PF00005); drug resistance ATP-binding protein 407333..409069 Arthrobacter arilaitensis Re117 9796390 YP_003915583.1 CDS AARI_03760 NC_014550.1 409105 410085 R identified by match to PF08240. Zn-dependent alcohol dehydrogenases catalyse the following reaction: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH; Zn-dependent alcohol dehydrogenase complement(409105..410085) Arthrobacter arilaitensis Re117 9796391 YP_003915584.1 CDS AARI_03770 NC_014550.1 410151 411626 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(410151..411626) Arthrobacter arilaitensis Re117 9796392 YP_003915585.1 CDS AARI_03780 NC_014550.1 411633 413063 R 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(411633..413063) Arthrobacter arilaitensis Re117 9796393 YP_003915586.1 CDS AARI_03790 NC_014550.1 413107 413466 R match to PS00430: TonB-dependent receptor proteins signature. In Escherichia coli the TonB protein interacts with outer membrane receptor proteins that carry out high- affinity binding and energy-dependent uptake of specific substrates into the periplasmic space. 2 transmembrane helices predicted by TMHMM2.0; TonB-box containing protein complement(413107..413466) Arthrobacter arilaitensis Re117 9796394 YP_003915587.1 CDS AARI_03800 NC_014550.1 413569 414174 D identified by match to protein domain PF08241; SAM-dependent methyltransferase 413569..414174 Arthrobacter arilaitensis Re117 9796395 YP_003915588.1 CDS AARI_03810 NC_014550.1 414175 414441 R hypothetical protein complement(414175..414441) Arthrobacter arilaitensis Re117 9796396 YP_003915589.1 CDS AARI_03820 NC_014550.1 414444 416066 R identified by match to protein family PF01551. Members of this family are zinc metallopeptidases with a range of specificities. Peptidase family M23 are also endopeptidases. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0. 740 between position 37 and 38; peptidase M23 complement(414444..416066) Arthrobacter arilaitensis Re117 9796397 YP_003915590.1 CDS AARI_03830 NC_014550.1 416073 416720 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(416073..416720) Arthrobacter arilaitensis Re117 9796398 YP_003915591.1 CDS AARI_03840 NC_014550.1 416796 417902 R match to protein family PF02195. Proteins containing this domain, appear to be related to the Escherichia coli plasmid protein ParB, which preferentially cleaves single-stranded DNA; ParB-like protein complement(416796..417902) Arthrobacter arilaitensis Re117 9796399 YP_003915592.1 CDS AARI_03850 NC_014550.1 417886 418812 R hypothetical protein complement(417886..418812) Arthrobacter arilaitensis Re117 9796400 YP_003915593.1 CDS AARI_03860 NC_014550.1 418819 419253 R hypothetical protein complement(418819..419253) Arthrobacter arilaitensis Re117 9796401 YP_003915594.1 CDS AARI_03870 NC_014550.1 419250 419981 R similar to excisionases from Mycobacterium phages; phage excisionase complement(419250..419981) Arthrobacter arilaitensis Re117 9796402 YP_003915595.1 CDS AARI_03880 NC_014550.1 419978 420883 R match to protein family PF09250; bifunctional primase/DNA polymerase protein complement(419978..420883) Arthrobacter arilaitensis Re117 9796403 YP_003915596.1 CDS AARI_03890 NC_014550.1 420885 421976 R hypothetical protein complement(420885..421976) Arthrobacter arilaitensis Re117 9796404 YP_003915597.1 CDS AARI_03900 NC_014550.1 422211 423167 R identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family; AraC family transcriptional regulator complement(422211..423167) Arthrobacter arilaitensis Re117 9796405 YP_003915598.1 CDS AARI_03910 NC_014550.1 423172 424479 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter complement(423172..424479) Arthrobacter arilaitensis Re117 9796406 YP_003915599.1 CDS AARI_03920 NC_014550.1 424558 426144 R TCDB: ATP-binding cassette (ABC) superfamily, siderophore-Fe3+ uptake transporter (SIUT) family (TC 3.A. 1.21.z). ABCISSE: ABC transporter, permease and ATP- binding protein (IM-ABC), DPL-family, SID-subfamily (siderophore uptake); iron-siderophore ABC transporter ATPase and permease components complement(424558..426144) Arthrobacter arilaitensis Re117 9796407 YP_003915600.1 CDS AARI_03930 NC_014550.1 426141 427748 R TCDB: ATP-binding cassette (ABC) superfamily, siderophore-Fe3+ uptake transporter (SIUT) family (TC 3.A. 1.21.z). ABCISSE: ABC transporter, permease and ATP- binding protein (IM-ABC), DPL-family, SID-subfamily (siderophore uptake); iron-siderophore ABC transporter ATPase and permease components complement(426141..427748) Arthrobacter arilaitensis Re117 9796408 YP_003915601.1 CDS AARI_03940 NC_014550.1 427748 428623 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter ATP-binding subunit complement(427748..428623) Arthrobacter arilaitensis Re117 9796409 YP_003915602.1 CDS AARI_03950 NC_014550.1 428629 429708 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(428629..429708) Arthrobacter arilaitensis Re117 9796410 YP_003915603.1 CDS AARI_03960 NC_014550.1 429705 430670 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(429705..430670) Arthrobacter arilaitensis Re117 9796411 YP_003915604.1 CDS AARI_03970 NC_014550.1 430844 431908 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(430844..431908) Arthrobacter arilaitensis Re117 9796412 YP_003915605.1 CDS AARI_03980 NC_014550.1 431953 433041 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(431953..433041) Arthrobacter arilaitensis Re117 9796413 YP_003915606.1 CDS AARI_03990 NC_014550.1 433038 434225 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter complement(433038..434225) Arthrobacter arilaitensis Re117 9796414 YP_003915607.1 CDS AARI_04000 NC_014550.1 434316 435137 R identified by match to protein family PF04954. Match to protein domain PF08021. Possibly involved in removal of iron from iron-siderophore complexes; siderophore-interacting protein complement(434316..435137) Arthrobacter arilaitensis Re117 9796415 YP_003915608.1 CDS AARI_04010 NC_014550.1 435302 436891 D identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family; AraC family transcriptional regulator 435302..436891 Arthrobacter arilaitensis Re117 9796416 YP_003915609.1 CDS AARI_04020 NC_014550.1 436993 438168 R C-5 cytosine-specific DNA methylases are enzymes that specifically methylate the C-5 carbon of cytosines in DNA. They are found as a component of type II restriction- modification systems in prokaryotes and some bacteriophages; DNA (cytosine-5-)-methyltransferase complement(436993..438168) Arthrobacter arilaitensis Re117 9796417 YP_003915610.1 CDS AARI_04030 NC_014550.1 438399 441944 D match to PF08751: TrwC relaxase. Similar to proteins involved in the conjugal tranfer of plasmids; conjugal transfer protein 438399..441944 Arthrobacter arilaitensis Re117 9796418 YP_003915611.1 CDS AARI_04040 NC_014550.1 442008 443009 R the SMF family (DNA processing chain A, dprA) are a group of bacterial proteins. In Helicobacter pylori, dprA is required for natural chromosomal and plasmid transformation; smf family protein complement(442008..443009) Arthrobacter arilaitensis Re117 9796419 YP_003915612.1 CDS AARI_04050 NC_014550.1 443069 443413 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(443069..443413) Arthrobacter arilaitensis Re117 9796420 YP_003915613.1 CDS AARI_04070 NC_014550.1 445497 446579 D match to protein family PF00589. Possible phage integrase or tyrosine recombinase subunit; phage integrase family protein 445497..446579 Arthrobacter arilaitensis Re117 9797150 YP_003915614.1 CDS AARI_04080 NC_014550.1 446671 448464 D match to protein family PF00589. Possible phage integrase or tyrosine recombinase subunit; phage integrase family protein 446671..448464 Arthrobacter arilaitensis Re117 9796423 YP_003915615.1 CDS AARI_04090 NC_014550.1 448461 448769 D hypothetical protein 448461..448769 Arthrobacter arilaitensis Re117 9796424 YP_003915616.1 CDS AARI_04110 NC_014550.1 449892 450773 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(449892..450773) Arthrobacter arilaitensis Re117 9796426 YP_003915617.1 CDS AARI_04120 NC_014550.1 450770 451483 R TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC), DRI-family, DRB-subfamily (drug resistance, ). Possible function in drug efflux; drug resistance ATP-binding protein complement(450770..451483) Arthrobacter arilaitensis Re117 9796427 YP_003915618.1 CDS AARI_04130 NC_014550.1 451486 452190 R 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(451486..452190) Arthrobacter arilaitensis Re117 9796428 YP_003915619.1 CDS AARI_04140 NC_014550.1 452342 453586 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 6 transmembrane helices predicted by TMHMM2.0; signal transduction histidine kinase 452342..453586 Arthrobacter arilaitensis Re117 9796429 YP_003915620.1 CDS AARI_04150 NC_014550.1 453583 454257 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 453583..454257 Arthrobacter arilaitensis Re117 9796430 YP_003915621.1 CDS AARI_04160 NC_014550.1 454254 454814 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 454254..454814 Arthrobacter arilaitensis Re117 9796431 YP_003915622.1 CDS AARI_04170 NC_014550.1 455296 455838 R hypothetical protein complement(455296..455838) Arthrobacter arilaitensis Re117 9796432 YP_003915623.1 CDS AARI_04180 NC_014550.1 455835 456035 R hypothetical protein complement(455835..456035) Arthrobacter arilaitensis Re117 9796433 YP_003915624.1 CDS AARI_04190 NC_014550.1 456087 456707 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(456087..456707) Arthrobacter arilaitensis Re117 9796515 YP_003915625.1 CDS AARI_04200 NC_014550.1 456750 457802 R identified by match to protein family PF00849. Pseudouridylate synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5- ribosyluracil, psi); pseudouridylate synthase complement(456750..457802) Arthrobacter arilaitensis Re117 9796516 YP_003915626.1 CDS AARI_04210 NC_014550.1 457863 458699 D identified by match to protein family PF02567. PhzC/PhzF is involved in dimerisation of two 2, 3-dihydro-3- oxo-anthranilic acid molecules to create phenazine-1- carboxylic acid (PCA) by P. fluorescens. This family also contains a thymidilate synthase from Mycobacterium tuberculosis. Many phenazine compounds are found in nature and are produced by bacteria such as Pseudomonas spp., Streptomyces spp., and Pantoea agglomerans. These compounds have been implicated in the virulence and competitive fitness of producing organisms. For example, the phenazine pyocyanin produced by Pseudomonas aeruginosa contributes to its ability to colonise the lungs of cystic fibrosis patients. Similarly, phenazine-1-carboxylic acid, produced by a number of Pseudomonas, increases survival in soil environments and has been shown to be essential for the biological control activity of certain strains; phenazine biosynthesis protein PhzC/PhzF 457863..458699 Arthrobacter arilaitensis Re117 9796517 YP_003915627.1 CDS nei NC_014550.1 458721 459545 R involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; DNA glycosylase complement(458721..459545) Arthrobacter arilaitensis Re117 9796518 YP_003915628.1 CDS AARI_04230 NC_014550.1 459570 464234 R may be involved in DNA repair; ATP-dependent DNA helicase complement(459570..464234) Arthrobacter arilaitensis Re117 9794138 YP_003915629.1 CDS AARI_04240 NC_014550.1 464274 464576 R match to protein domain IPR011991: winged helix repressor DNA-binding; transcriptional regulator complement(464274..464576) Arthrobacter arilaitensis Re117 9796519 YP_003915630.1 CDS AARI_04250 NC_014550.1 464560 465021 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(464560..465021) Arthrobacter arilaitensis Re117 9796520 YP_003915631.1 CDS AARI_04260 NC_014550.1 465026 465490 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(465026..465490) Arthrobacter arilaitensis Re117 9796521 YP_003915632.1 CDS AARI_04270 NC_014550.1 465554 466012 R hypothetical protein complement(465554..466012) Arthrobacter arilaitensis Re117 9796522 YP_003915633.1 CDS AARI_04280 NC_014550.1 466076 466789 D PAP2 family protein 466076..466789 Arthrobacter arilaitensis Re117 9796523 YP_003915634.1 CDS AARI_04290 NC_014550.1 466758 467729 R D-isomer specific 2-hydroxyacid dehydrogenase family protein complement(466758..467729) Arthrobacter arilaitensis Re117 9796524 YP_003915635.1 CDS AARI_04300 NC_014550.1 467826 469673 R match to PF00149. The metallophosphoesterase motif is found in a large number of proteins invoved in phosphorylation. These include Ser/Thr phosphatases, DNA polymerase, exonucleases, and other phosphatases; metallophosphoesterase complement(467826..469673) Arthrobacter arilaitensis Re117 9796525 YP_003915636.1 CDS AARI_04310 NC_014550.1 469854 470981 D hypothetical protein 469854..470981 Arthrobacter arilaitensis Re117 9796526 YP_003915637.1 CDS AARI_04320 NC_014550.1 471031 471462 D match to protein domain PF03061: thioesterase superfamily; thioesterase family domain-containing protein 471031..471462 Arthrobacter arilaitensis Re117 9796527 YP_003915638.1 CDS AARI_04350 NC_014550.1 472554 473849 D benzoate:H+ symporter (BenE) family, benzoate permease (TC 2.A.46.1.1). Identified by match to protein family PF03594; benzoate permease 472554..473849 Arthrobacter arilaitensis Re117 9796530 YP_003915639.1 CDS AARI_04360 NC_014550.1 473971 474762 D catalyzes the first step in NAD biosynthesis from aspartate. Specifically catalyzes the NAD or NADP- dependent dehydrogenation of L-aspartate to iminoaspartate; aspartate dehydrogenase 473971..474762 Arthrobacter arilaitensis Re117 9796531 YP_003915640.1 CDS pcaC NC_014550.1 474779 475186 R involved in protocatechuate catabolism; 4-carboxymuconolactone decarboxylase complement(474779..475186) Arthrobacter arilaitensis Re117 9796532 YP_003915641.1 CDS pcaD NC_014550.1 475205 475975 R 3-oxoadipate enol-lactonase catalyses the formation of 3-oxoadipate from 3-oxoadipate enol-lactone. It is involved in aromatic acids catabolism; 3-oxoadipate enol-lactonase complement(475205..475975) Arthrobacter arilaitensis Re117 9794181 YP_003915642.1 CDS pcaB NC_014550.1 475984 477390 R catalyses the cyclization of 3-carboxy-cis,cis- muconate to 4-carboxy-muconolactone. Involved in aromatic acids catabolism; 3-carboxy-cis,cis-muconate cycloisomerase complement(475984..477390) Arthrobacter arilaitensis Re117 9794182 YP_003915643.1 CDS pcaG NC_014550.1 477536 478114 R catalyses the following reaction: 3,4- dihydroxybenzoate + O(2) <=> 3-carboxy-cis,cis-muconate; protocatechuate 3,4-dioxygenase subunit alpha complement(477536..478114) Arthrobacter arilaitensis Re117 9794180 YP_003915644.1 CDS pcaH NC_014550.1 478116 478964 R catalyses the following reaction: 3,4- dihydroxybenzoate + O(2) <=> 3-carboxy-cis,cis-muconate; protocatechuate 3,4-dioxygenase subunit beta complement(478116..478964) Arthrobacter arilaitensis Re117 9794183 YP_003915645.1 CDS pobA NC_014550.1 479005 480201 R catalyses the following reaction: 4-hydroxybenzoate + NADPH + O(2) <=> protocatechuate + NADP(+) + H(2)O; 4-hydroxybenzoate 3-monooxygenase complement(479005..480201) Arthrobacter arilaitensis Re117 9794184 YP_003915646.1 CDS AARI_04430 NC_014550.1 480419 481165 R identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator complement(480419..481165) Arthrobacter arilaitensis Re117 9794212 YP_003915647.1 CDS AARI_04440 NC_014550.1 481414 482082 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.321 between position 26 and 27; hypothetical protein 481414..482082 Arthrobacter arilaitensis Re117 9796533 YP_003915648.1 CDS AARI_04450 NC_014550.1 482258 483469 D acetyl-CoA C-acyltransferase (also named 3-ketoacyl- CoA thiolase or thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation; acetyl-CoA C-acyltransferase 482258..483469 Arthrobacter arilaitensis Re117 9796534 YP_003915649.1 CDS pcaI NC_014550.1 483489 484160 D identified by similarity to protein SP:Q01103 (Pseudomonas putida). Catalyses the following reaction : succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA; 3-oxoadipate CoA-transferase subunit A 483489..484160 Arthrobacter arilaitensis Re117 9796535 YP_003915650.1 CDS pcaJ NC_014550.1 484160 484807 D identified by similarity to protein SP: P0A102 (Pseudomonas putida). Catalyses the following reaction : succinyl-CoA + 3-oxoadipate = succinate + 3-oxoadipyl-CoA; 3-oxoadipate CoA-transferase subunit B 484160..484807 Arthrobacter arilaitensis Re117 9794185 YP_003915651.1 CDS AARI_04480 NC_014550.1 484829 485671 D identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 484829..485671 Arthrobacter arilaitensis Re117 9794186 YP_003915652.1 CDS AARI_04490 NC_014550.1 485760 486152 R match to protein domain IPR011588: glyoxalase/extradiol ring-cleavage dioxygenase domain; hypothetical protein complement(485760..486152) Arthrobacter arilaitensis Re117 9796536 YP_003915653.1 CDS AARI_04500 NC_014550.1 486247 487128 R triacylglycerol lipase hydrolyzes ester bonds in triacylglycerol giving diacylglycerol, monoacylglycerol, glycerol and free fatty acids. Signal peptide predicted by SignalP 3.0 HMM (probability: 1) with cleavage site probability 0.991 between position 34 and 35; triacylglycerol lipase complement(486247..487128) Arthrobacter arilaitensis Re117 9796537 YP_003915654.1 CDS AARI_04510 NC_014550.1 487599 488249 D identified by match to protein family PF02230. This family consists of both phospholipases and carboxylesterases with broad substrate specificity; phospholipase/carboxylesterase 487599..488249 Arthrobacter arilaitensis Re117 9796538 YP_003915655.1 CDS AARI_04520 NC_014550.1 488299 488592 D hypothetical protein 488299..488592 Arthrobacter arilaitensis Re117 9796539 YP_003915656.1 CDS AARI_04530 NC_014550.1 488634 489740 R 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(488634..489740) Arthrobacter arilaitensis Re117 9796540 YP_003915657.1 CDS AARI_04540 NC_014550.1 489813 490244 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 489813..490244 Arthrobacter arilaitensis Re117 9796541 YP_003915658.1 CDS AARI_04550 NC_014550.1 490269 490478 R hypothetical protein complement(490269..490478) Arthrobacter arilaitensis Re117 9796542 YP_003915659.1 CDS mog NC_014550.1 490517 491008 R involved in molybdoterin cofactor biosynthesis. Catalyses the following reaction: molybdopterin + ATP --> molybdopterin-AMP + diphosphate. The function of several enzymes, such as xanthine oxidase, sulfite oxidase, nitrate reductase, depends on the molybdopterin cofactor; molybdopterin adenylyltransferase complement(490517..491008) Arthrobacter arilaitensis Re117 9796543 YP_003915660.1 CDS moaC NC_014550.1 490998 491474 R is involved, together with MoaA, in the conversion of a guanosine derivative (5 -GTP) into the molybdopterin precursor Z. The function of several enzymes, such as xanthine oxidase, sulfite oxidase, nitrate reductase, depends on the molybdopterin cofactor; molybdenum cofactor biosynthesis protein C complement(490998..491474) Arthrobacter arilaitensis Re117 9794103 YP_003915661.1 CDS moeA NC_014550.1 491467 492699 R involved in the biosynthesis of a demolybdo- cofactor (molybdopterin), necessary for molybdo-enzymes such as xanthine oxidase, sulfite oxidase, nitrate reductase: molybdopterin-AMP + molybdate --> molybdenum cofactor + AMP + H2O; molybdopterin biosynthesis protein MoeA complement(491467..492699) Arthrobacter arilaitensis Re117 9794095 YP_003915662.1 CDS moaD NC_014550.1 492703 492954 R molybdoterin synthase converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. Heterodimer of 2 MoaD subunits and 2 MoaE subunits; molybdopterin-converting factor small subunit MoaD complement(492703..492954) Arthrobacter arilaitensis Re117 9794101 YP_003915663.1 CDS moeB NC_014550.1 492992 494173 D involved in the biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. Plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD); molybdopterin biosynthesis protein MoeB 492992..494173 Arthrobacter arilaitensis Re117 9794096 YP_003915664.1 CDS moaE NC_014550.1 494170 494577 D molybdoterin synthase converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. Heterodimer of 2 MoaD subunits and 2 MoaE subunits; molybdopterin-converting factor large subunit MoaE 494170..494577 Arthrobacter arilaitensis Re117 9794102 YP_003915665.1 CDS AARI_04620 NC_014550.1 494626 495042 D hypothetical protein 494626..495042 Arthrobacter arilaitensis Re117 9794097 YP_003915666.1 CDS AARI_04630 NC_014550.1 495175 496131 R transcriptional regulator complement(495175..496131) Arthrobacter arilaitensis Re117 9796544 YP_003915667.1 CDS AARI_04640 NC_014550.1 496236 496784 D hypothetical protein 496236..496784 Arthrobacter arilaitensis Re117 9796545 YP_003915668.1 CDS moaA NC_014550.1 496781 497821 R is involved, together with MoaC, in the conversion of a guanosine derivative (5 -GTP) into the molybdopterin precursor Z. The function of several enzymes, such as xanthine oxidase, sulfite oxidase, nitrate reductase, depends on the molybdopterin cofactor; molybdenum cofactor biosynthesis protein A complement(496781..497821) Arthrobacter arilaitensis Re117 9796546 YP_003915669.1 CDS modA NC_014550.1 497954 498724 D TCDB: ATP-binding cassette (ABC) superfamily, MolT- family (molybdate uptake transporter), molybdate porter (TC 3.A.1.8.1). ABCISSE: ABC transporter, binding protein (BP), MOI-family, molybdate import. Part of the ABC transporter complex ModABC involved in molybdate import; molybdate ABC transporter substrate-binding protein ModA 497954..498724 Arthrobacter arilaitensis Re117 9794094 YP_003915670.1 CDS modB NC_014550.1 498717 499523 D TCDB: ATP-binding cassette (ABC) superfamily, MolT- family (molybdate uptake transporter), molybdate porter (TC 3.A.1.8.1). ABCISSE: ABC transporter, permease (IM), MOI-family, molybdate import. Part of the ABC transporter complex ModABC involved in molybdate import; molybdate ABC transporter inner membrane subunit ModB 498717..499523 Arthrobacter arilaitensis Re117 9794099 YP_003915671.1 CDS AARI_04680 NC_014550.1 499520 501517 D N-terminal section of the protein: ABC transporter, ATP-binding subunit ModC; TCDB: ATP-binding cassette (ABC) superfamily, MolT-family (molybdate uptake transporter), molybdate porter (TC 3.A.1.8.1). ABCISSE: ABC transporter, ATP-binding protein (ABC), MOI-family, molybdate import. Part of the ABC transporter complex ModABC involved in molybdate import. C-terminal section of the protein: molybdopterin biosynthesis protein MoeA; involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes such as xanthine oxidase, sulfite oxidase, nitrate reductase: molybdopterin-AMP + molybdate --> molybdenum cofactor + AMP + H2O; molybdate transport/synthesis fusion protein 499520..501517 Arthrobacter arilaitensis Re117 9794100 YP_003915672.1 CDS mobA NC_014550.1 501514 502392 D links a guanosine 5 -phosphate to molydopterin, forming molybdopterin guanine dinucleotide: molybdenum cofactor + GTP = molybdopterin guanine dinucleotide + diphosphate + 2 H2O; molybdopterin-guanine dinucleotide biosynthesis protein A 501514..502392 Arthrobacter arilaitensis Re117 9796547 YP_003915673.1 CDS AARI_04700 NC_014550.1 502481 503380 R match to PF02683: Cytochrome C biogenesis protein transmembrane region; disulfide bond formation protein complement(502481..503380) Arthrobacter arilaitensis Re117 9794098 YP_003915674.1 CDS AARI_04710 NC_014550.1 503380 504129 R match to protein domain PF01323; DSBA-like thioredoxin domain-containing protein complement(503380..504129) Arthrobacter arilaitensis Re117 9796548 YP_003915675.1 CDS AARI_04720 NC_014550.1 504458 505471 R permease complement(504458..505471) Arthrobacter arilaitensis Re117 9796549 YP_003915676.1 CDS AARI_04730 NC_014550.1 505636 506529 D identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator 505636..506529 Arthrobacter arilaitensis Re117 9796550 YP_003915677.1 CDS narI NC_014550.1 506703 507473 R the respiratory nitrate reductase enzyme complex allows the bacteria to use nitrate as an electron acceptor during anaerobic growth. The gamma subunit is a b-type cytochrome that receives electrons from the quinone pool. It then transfers these via the iron-sulfur clusters of the beta subunit to the molybdenum cofactor found in the alpha subunit; respiratory nitrate reductase gamma subunit complement(506703..507473) Arthrobacter arilaitensis Re117 9796551 YP_003915678.1 CDS narJ NC_014550.1 507470 508168 R the respiratory nitrate reductase enzyme complex allows the bacteria to use nitrate as an electron acceptor during anaerobic growth. The delta subunit is not part of the nitrate reductase enzyme but is most likely needed for assembly of the multi-subunit enzyme complex; respiratory nitrate reductase delta subunit complement(507470..508168) Arthrobacter arilaitensis Re117 9794134 YP_003915679.1 CDS narH NC_014550.1 508165 509802 R the respiratory nitrate reductase enzyme complex allows the bacteria to use nitrate as an electron acceptor during anaerobic growth; respiratory nitrate reductase beta subunit complement(508165..509802) Arthrobacter arilaitensis Re117 9794135 YP_003915680.1 CDS AARI_04790 NC_014550.1 513815 514966 D major facilitator superfamily, nitrate/nitrite porter family, 24 TMS, 2 domain, NarK1-NarK2 porter (TC 2. A.1.8.11). In Paracoccus pantotrophus, this transporter comprises 2 domains: NarK1, a NO3-/H+ symporter; and NarK2, a NO3-/NO2- antiporter; nitrate/nitrite transporter 513815..514966 Arthrobacter arilaitensis Re117 9796553 YP_003915681.1 CDS AARI_04800 NC_014550.1 515046 515588 D identified by match to protein family PF07152. This family consists of several hypothetical bacterial proteins of around 180 residues in length, which are often known as YaeQ. YaeQ is homologous to RfaH, a specialised transcription elongation protein. YaeQ is known to compensate for loss of RfaH function in Escherichia coli and Salmonella typhimurium; YaeQ family protein 515046..515588 Arthrobacter arilaitensis Re117 9796554 YP_003915682.1 CDS glpQ NC_014550.1 515686 516762 D glycerophosphoryl diester phosphodiesterases display broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol); glycerophosphodiester phosphodiesterase 515686..516762 Arthrobacter arilaitensis Re117 9796555 YP_003915683.1 CDS AARI_04820 NC_014550.1 517349 517741 R hypothetical protein complement(517349..517741) Arthrobacter arilaitensis Re117 9793914 YP_003915684.1 CDS codA NC_014550.1 518529 519005 R catalyzes the hydrolysis of cytosine into uracil and ammonia; cytosine deaminase complement(518529..519005) Arthrobacter arilaitensis Re117 9793582 YP_003915685.1 CDS upp NC_014550.1 519175 519822 D catalyses the formation of UMP and diphosphate from uracil and 5-phospho-alpha-D-ribose 1-diphosphate; uracil phosphoribosyltransferase 519175..519822 Arthrobacter arilaitensis Re117 9793753 YP_003915686.1 CDS AARI_04850 NC_014550.1 519859 521370 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(519859..521370) Arthrobacter arilaitensis Re117 9794490 YP_003915687.1 CDS AARI_04860 NC_014550.1 521367 522107 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(521367..522107) Arthrobacter arilaitensis Re117 9796557 YP_003915688.1 CDS AARI_04870 NC_014550.1 522722 523507 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 522722..523507 Arthrobacter arilaitensis Re117 9796558 YP_003915689.1 CDS AARI_04880 NC_014550.1 523577 524104 D COG2062; phosphohistidine phosphatase SixA from Escherichia coli exhibits phosphatase activity towards the HPT domain of the ArcB sensor involved in the multistep his-asp phosphorelay; regulatory protein 523577..524104 Arthrobacter arilaitensis Re117 9796559 YP_003915690.1 CDS AARI_04890 NC_014550.1 524331 525458 D hypothetical protein 524331..525458 Arthrobacter arilaitensis Re117 9796560 YP_003915691.1 CDS AARI_04900 NC_014550.1 525467 527080 D TC 3.A.1.117.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, antibiotic resistance or production (ARP) subfamily. Possible function in antibiotic resistance or production (export); drug resistance ATP-binding protein 525467..527080 Arthrobacter arilaitensis Re117 9796561 YP_003915692.1 CDS AARI_04910 NC_014550.1 527077 527688 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(527077..527688) Arthrobacter arilaitensis Re117 9796562 YP_003915693.1 CDS AARI_04920 NC_014550.1 527685 530015 R TC 9.B.74.y.z. The phage infection protein (PIP) family is a transport protein family. Identified by match to protein domains TIGR03061 and TIGR03062; PIP family transporter complement(527685..530015) Arthrobacter arilaitensis Re117 9796563 YP_003915694.1 CDS AARI_04930 NC_014550.1 530019 530801 R hypothetical protein complement(530019..530801) Arthrobacter arilaitensis Re117 9796564 YP_003915695.1 CDS AARI_04940 NC_014550.1 531023 532939 D match to PF03372: Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.974 between position 28 and 29; extracellular nuclease 531023..532939 Arthrobacter arilaitensis Re117 9796565 YP_003915696.1 CDS bglA NC_014550.1 534691 535854 D identified by similarity to protein SP: Q9LAV7 (Thermobifida fusca). TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1.1.z). ABCISSE: ABC transporter, permease (IM), OSP-family (oligosaccharides or polyols), cellobiose import; cellobiose ABC transporter inner membrane subunit BglA 534691..535854 Arthrobacter arilaitensis Re117 9796568 YP_003915697.1 CDS bglB NC_014550.1 535862 536734 D identified by similarity to protein SP: Q9LAV6 (Thermobifida fusca). TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1.1.z). ABCISSE: ABC transporter, binding protein (BP), OSP-family (oligosaccharides or polyols), cellobiose import; cellobiose ABC transporter substrate-binding protein BglB 535862..536734 Arthrobacter arilaitensis Re117 9793713 YP_003915698.1 CDS bglC NC_014550.1 536734 538152 D identified by similarity to protein SP:Q9LAV5 (Thermobifida fusca). In Thermobifida fusca, bglC is most active against cellobiose; beta-glucosidase BglC 536734..538152 Arthrobacter arilaitensis Re117 9793714 YP_003915699.1 CDS celR NC_014550.1 538247 539266 D identified by similarity to protein SP:O87590 (Thermobifida fusca). In Thermobifida fusca, CelR Binds to the 14-bp operator sequence 5-TGGGAGCGCTCCCA-3 in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose; LacI family transcriptional regulator CelR 538247..539266 Arthrobacter arilaitensis Re117 9793715 YP_003915700.1 CDS AARI_05020 NC_014550.1 539984 540097 R hypothetical protein complement(539984..540097) Arthrobacter arilaitensis Re117 9796569 YP_003915701.1 CDS pckG NC_014550.1 540550 542382 D catalyzes the formation of phosphoenolpyruvate by decarboxylation of oxaloacetate while hydrolyzing GTP; phosphoenolpyruvate carboxykinase (GTP) 540550..542382 Arthrobacter arilaitensis Re117 9793584 YP_003915702.1 CDS AARI_05040 NC_014550.1 542551 543078 D identified by match to protein family PF03551; PadR-like family transcriptional regulator 542551..543078 Arthrobacter arilaitensis Re117 9794187 YP_003915703.1 CDS AARI_05050 NC_014550.1 543075 544157 D match to PF00561: alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; hydrolase 543075..544157 Arthrobacter arilaitensis Re117 9796571 YP_003915704.1 CDS AARI_05060 NC_014550.1 544225 545400 R flavohemoproteins from bacteria (e.g. Escherichia coli hmpA) and fungi consist of two distinct domains, an N- terminal globin domain and a C-terminal FAD-containing reductase domain; flavohemoprotein complement(544225..545400) Arthrobacter arilaitensis Re117 9796572 YP_003915705.1 CDS AARI_05070 NC_014550.1 545546 546004 R identified by match to protein family PF02082; transcriptional regulator complement(545546..546004) Arthrobacter arilaitensis Re117 9796573 YP_003915706.1 CDS AARI_05080 NC_014550.1 546082 546552 R hypothetical protein complement(546082..546552) Arthrobacter arilaitensis Re117 9796574 YP_003915707.1 CDS manB NC_014550.1 546565 547989 R catalyses the following reaction: alpha-D-mannose 1- phosphate <=> D-mannose 6-phosphate; phosphomannomutase complement(546565..547989) Arthrobacter arilaitensis Re117 9796575 YP_003915708.1 CDS AARI_05100 NC_014550.1 548166 550286 D match to protein family TIGR00614: recQ family; ATP-dependent DNA helicase 548166..550286 Arthrobacter arilaitensis Re117 9794056 YP_003915709.1 CDS AARI_05110 NC_014550.1 550317 551225 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 550317..551225 Arthrobacter arilaitensis Re117 9796576 YP_003915710.1 CDS AARI_05120 NC_014550.1 551768 553855 R identified by match to PF00326 and PF02897. Prolyl oligopeptidase family consist of a number of evolutionary related peptidases whose catalytic activity seems to be provided by a charge relay system similar to that of the trypsin family of serine proteases, but which evolved by independent convergent evolution; prolyl oligopeptidase complement(551768..553855) Arthrobacter arilaitensis Re117 9793585 YP_003915711.1 CDS AARI_05130 NC_014550.1 553912 555927 D hypothetical protein 553912..555927 Arthrobacter arilaitensis Re117 9796578 YP_003915712.1 CDS qor NC_014550.1 556113 557102 D NADPH:quinone reductase catalyzes the following reaction: NADPH + quinone <=> NADP(+) + semiquinone. Quinone or similar compounds may act as acceptor; NADPH:quinone reductase 556113..557102 Arthrobacter arilaitensis Re117 9793586 YP_003915713.1 CDS AARI_05150 NC_014550.1 558231 558422 D hypothetical protein 558231..558422 Arthrobacter arilaitensis Re117 9797151 YP_003915714.1 CDS AARI_05160 NC_014550.1 558576 559025 D hypothetical protein 558576..559025 Arthrobacter arilaitensis Re117 9796580 YP_003915715.1 CDS dkgA NC_014550.1 560320 561162 D catalyzes the reduction of 2,5-diketogluconic acid to 2-keto-L-gulonic acid, a key intermediate in the production of ascorbic acid. Can also reduce ethyl 2- methylacetoacetate stereoselectively to ethyl (2R)-methyl- (3S)-hydroxybutanoate and can also accept some other beta- keto esters. Identified by similarity to protein SP:Q46857 (Escherichia coli); 2,5-didehydrogluconate reductase 560320..561162 Arthrobacter arilaitensis Re117 9797154 YP_003915716.1 CDS AARI_05180 NC_014550.1 561520 563037 R match to protein family PF08386. This is a C- terminal domain associated with hydrolases and bacterial peptidases that belong to MEROPS peptidase family S33 (clan SC). Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.604 between position 25 and 26; peptidase S33 complement(561520..563037) Arthrobacter arilaitensis Re117 9793587 YP_003915717.1 CDS AARI_05190 NC_014550.1 563079 564233 R DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta prime, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit delta prime complement(563079..564233) Arthrobacter arilaitensis Re117 9796582 YP_003915718.1 CDS tmk NC_014550.1 564230 564883 R catalyzes the phosphorylation of thymidine 5- monophosphate (dTMP) to thymidine 5-diphosphate (dTDP) in the presence of ATP and magnesium; dTMP kinase complement(564230..564883) Arthrobacter arilaitensis Re117 9796583 YP_003915719.1 CDS metB NC_014550.1 566256 567413 D catalyzes the conversion of cysteine and succinyl- homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms; cystathionine gamma-synthase 566256..567413 Arthrobacter arilaitensis Re117 9797156 YP_003915720.1 CDS AARI_05220 NC_014550.1 567485 567802 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 567485..567802 Arthrobacter arilaitensis Re117 9794067 YP_003915721.1 CDS gpmA NC_014550.1 567935 568681 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 567935..568681 Arthrobacter arilaitensis Re117 9796584 YP_003915722.1 CDS AARI_05240 NC_014550.1 568880 569182 D hypothetical protein 568880..569182 Arthrobacter arilaitensis Re117 9793933 YP_003915723.1 CDS phoU NC_014550.1 569427 570080 R probably involved in phosphate transport and/or metabolism. Identified by match to PF01895; phosphate transport system regulatory protein PhoU complement(569427..570080) Arthrobacter arilaitensis Re117 9796585 YP_003915724.1 CDS AARI_05260 NC_014550.1 570317 571522 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase 570317..571522 Arthrobacter arilaitensis Re117 9794206 YP_003915725.1 CDS AARI_05270 NC_014550.1 571519 572199 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 571519..572199 Arthrobacter arilaitensis Re117 9796586 YP_003915726.1 CDS AARI_05280 NC_014550.1 572284 572823 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.991) with cleavage site probability 0.479 between position 35 and 36; hypothetical protein complement(572284..572823) Arthrobacter arilaitensis Re117 9796587 YP_003915727.1 CDS AARI_05290 NC_014550.1 573179 573664 D CarD is a Myxococcus xanthus protein required for the activation of light- and starvation-inducible genes; CarD transcriptional regulator-like protein 573179..573664 Arthrobacter arilaitensis Re117 9796588 YP_003915728.1 CDS ispDF NC_014550.1 573769 575010 D bifunctional enzyme catalyzing non-consecutive reactions in the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid precursor biosynthesis; bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein 573769..575010 Arthrobacter arilaitensis Re117 9796589 YP_003915729.1 CDS cysS NC_014550.1 575098 576549 D activates cysteine and transfers it to tRNA(Cys) as the first step in protein biosynthesis; cysteine--tRNA ligase 575098..576549 Arthrobacter arilaitensis Re117 9794011 YP_003915730.1 CDS AARI_05320 NC_014550.1 576600 577547 D identified by match to protein family PF00588: SpoU rRNA Methylase family. Possible role in rRNA modification; RNA methyltransferase 576600..577547 Arthrobacter arilaitensis Re117 9793784 YP_003915731.1 CDS AARI_05330 NC_014550.1 583851 584060 D hypothetical protein 583851..584060 Arthrobacter arilaitensis Re117 9793590 YP_003915732.1 CDS AARI_05340 NC_014550.1 584530 585906 D identified by match to PF02913 and PF01565; FAD linked oxidase domain-containing protein 584530..585906 Arthrobacter arilaitensis Re117 9796591 YP_003915733.1 CDS AARI_05350 NC_014550.1 586292 586927 D hypothetical protein 586292..586927 Arthrobacter arilaitensis Re117 9793591 YP_003915734.1 CDS AARI_05360 NC_014550.1 587613 588047 R hypothetical protein complement(587613..588047) Arthrobacter arilaitensis Re117 9796593 YP_003915735.1 CDS AARI_34550 NC_014550.1 588703 589902 R transposase of ISAar5, IS256 family complement(588703..589902) Arthrobacter arilaitensis Re117 9793593 YP_003915736.1 CDS AARI_05370 NC_014550.1 597118 597414 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 597118..597414 Arthrobacter arilaitensis Re117 9793596 YP_003915737.1 CDS AARI_05380 NC_014550.1 597710 598492 D dehydrogenase 597710..598492 Arthrobacter arilaitensis Re117 9796595 YP_003915738.1 CDS msiK NC_014550.1 598883 599950 R identified by similarity to protein SP:P96483 (Streptomyces reticuli). In Streptomyces reticuli, MsiK assists the cellobiose and maltose ABC transport systems. TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1.1.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OSP- family (oligosaccharides or polyols); cellobiose/maltose ABC transporter ATP-binding subunit MsiK complement(598883..599950) Arthrobacter arilaitensis Re117 9796677 YP_003915739.1 CDS otsB NC_014550.1 600016 600795 R synthesis of trehalose from trehalose-6-phosphate; trehalose-phosphatase complement(600016..600795) Arthrobacter arilaitensis Re117 9794109 YP_003915740.1 CDS otsA NC_014550.1 600838 602301 R synthesis of trehalose 6-phosphate from UDP-glucose and glucose-6-phosphate; alpha,alpha-trehalose-phosphate synthase complement(600838..602301) Arthrobacter arilaitensis Re117 9794162 YP_003915741.1 CDS AARI_05420 NC_014550.1 602701 603567 D match to protein domain PF01323; DSBA-like thioredoxin domain-containing protein 602701..603567 Arthrobacter arilaitensis Re117 9794161 YP_003915742.1 CDS AARI_05430 NC_014550.1 603981 604931 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 603981..604931 Arthrobacter arilaitensis Re117 9793597 YP_003915743.1 CDS AARI_05440 NC_014550.1 605042 606691 D match to PF02384. This domain is found in N-6 adenine-specific DNA methylase from type I and type IC restriction systems. These enzymes are responsible for the methylation of specific DNA sequences in order to prevent the host from digesting its own genome via its restriction enzymes. Match to PS00092 pattern: N-6 Adenine-specific DNA methylases signature; adenine-specific DNA-methyltransferase 605042..606691 Arthrobacter arilaitensis Re117 9796679 YP_003915744.1 CDS AARI_05450 NC_014550.1 606688 607620 D hypothetical protein 606688..607620 Arthrobacter arilaitensis Re117 9796680 YP_003915745.1 CDS AARI_05460 NC_014550.1 607625 608242 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(607625..608242) Arthrobacter arilaitensis Re117 9796681 YP_003915746.1 CDS AARI_05470 NC_014550.1 608787 609833 R identified by match to PF00296. Bacterial luciferase is a flavin monooxygenase that catalyses the oxidation of long-chain aldehydes and releases energy in the form of visible light, and which uses flavin as a substrate rather than a cofactor. There are structural similarities between bacterial luciferase and nonfluorescent flavoproteins (LuxF, FP390), alkanesulfonate monooxygenase (SsuD), and coenzyme F420- dependent terahydromethanopterin reductase, which make up clearly related families with somewhat different folds; luciferase-like monooxygenase complement(608787..609833) Arthrobacter arilaitensis Re117 9793598 YP_003915747.1 CDS AARI_05480 NC_014550.1 610034 611704 D 9 transmembrane helices predicted by TMHMM2.0; hypothetical protein 610034..611704 Arthrobacter arilaitensis Re117 9796683 YP_003915748.1 CDS ung NC_014550.1 611701 612375 R DNA repair enzyme that excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(611701..612375) Arthrobacter arilaitensis Re117 9796684 YP_003915749.1 CDS AARI_05500 NC_014550.1 612631 612921 D hypothetical protein 612631..612921 Arthrobacter arilaitensis Re117 9794489 YP_003915750.1 CDS AARI_05510 NC_014550.1 612964 613569 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 612964..613569 Arthrobacter arilaitensis Re117 9796685 YP_003915751.1 CDS groEL NC_014550.1 613868 615505 D chaperonins are involved in productive folding of proteins. With the aid of cochaperonin GroES, GroEL encapsulates non-native substrate proteins inside the cavity of the GroEL-ES complex and promotes folding by using energy derived from ATP hydrolysis; chaperonin GroEL 613868..615505 Arthrobacter arilaitensis Re117 9796686 YP_003915752.1 CDS AARI_05530 NC_014550.1 615609 616499 R hypothetical protein complement(615609..616499) Arthrobacter arilaitensis Re117 9793936 YP_003915753.1 CDS AARI_05540 NC_014550.1 616543 616833 R hypothetical protein complement(616543..616833) Arthrobacter arilaitensis Re117 9796687 YP_003915754.1 CDS AARI_05550 NC_014550.1 616947 618485 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(616947..618485) Arthrobacter arilaitensis Re117 9796688 YP_003915755.1 CDS AARI_05560 NC_014550.1 618538 619245 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(618538..619245) Arthrobacter arilaitensis Re117 9796689 YP_003915756.1 CDS AARI_05570 NC_014550.1 619304 619522 R hypothetical protein complement(619304..619522) Arthrobacter arilaitensis Re117 9796690 YP_003915757.1 CDS AARI_05580 NC_014550.1 619775 620158 D N-terminal section of the protein: match to PF00313 (cold-shock DNA-binding domain). The so-called cold shock proteins are thought to help the cell to survive in temperatures lower than optimum growth temperature, by contrast with heat shock proteins, which help the cell to survive in temperatures greater than the optimum, possibly by condensation of the chromosome and organization of the prokaryotic nucleoid; cold shock protein 619775..620158 Arthrobacter arilaitensis Re117 9796691 YP_003915758.1 CDS AARI_05590 NC_014550.1 620162 620773 D hypothetical protein 620162..620773 Arthrobacter arilaitensis Re117 9796692 YP_003915759.1 CDS serC NC_014550.1 620850 621971 R catalyzes the reversible interconversion of 3- phosphonooxypyruvate and glutamate to phosphoserine and 2- oxoglutarate to. It is required both in the major phosphorylated pathway of serine biosynthesis and in pyridoxine biosynthesis. Also catalyses the third step in the biosynthesis of the coenzyme pyridoxal 5-phosphate : (3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + L-glutamate <=> 4-phosphonooxy-L-threonine + 2-oxoglutarate; phosphoserine transaminase complement(620850..621971) Arthrobacter arilaitensis Re117 9796693 YP_003915760.1 CDS ideR NC_014550.1 622233 622928 D identified by similarity to protein SP:P0A672 (Mycobacterium tuberculosis). Iron-binding repressor of siderophore biosynthesis and iron uptake. Synonym: DtxR (Corynebacterium glutamicum); iron-dependent repressor IdeR 622233..622928 Arthrobacter arilaitensis Re117 9794394 YP_003915761.1 CDS AARI_05620 NC_014550.1 623191 624237 D identified by match to protein family PF01551. Members of this family are zinc metallopeptidases with a range of specificities. Peptidase family M23 are also endopeptidases; M23 family peptidase 623191..624237 Arthrobacter arilaitensis Re117 9793997 YP_003915762.1 CDS AARI_05630 NC_014550.1 624535 625362 D hypothetical protein 624535..625362 Arthrobacter arilaitensis Re117 9796694 YP_003915763.1 CDS AARI_05640 NC_014550.1 625966 626088 D hypothetical protein 625966..626088 Arthrobacter arilaitensis Re117 9796695 YP_003915764.1 CDS AARI_05650 NC_014550.1 626126 626536 R hypothetical protein complement(626126..626536) Arthrobacter arilaitensis Re117 9796696 YP_003915765.1 CDS AARI_05660 NC_014550.1 626725 627954 D identified by match to PF00480: ROK family; transcriptional regulator 626725..627954 Arthrobacter arilaitensis Re117 9796697 YP_003915766.1 CDS AARI_05670 NC_014550.1 628217 628879 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(628217..628879) Arthrobacter arilaitensis Re117 9793599 YP_003915767.1 CDS pcrA NC_014550.1 628964 631342 D an ATP-dependent DNA helicase which facilitates the progress of replication forks. Non-essential in Escherchichia coli, PcrA is an essential DNA helicase in Bacillus subtilis, fulfilling functions both in repair and rolling-circle replication; ATP-dependent DNA helicase PcrA 628964..631342 Arthrobacter arilaitensis Re117 9796699 YP_003915768.1 CDS sucC NC_014550.1 631585 632757 D succinyl-CoA synthetase, which is composed of alpha and beta subunits, catalyzes the interconversion of succinyl-CoA and succinate. Involved in the TCA cycle; succinyl-CoA synthetase beta subunit 631585..632757 Arthrobacter arilaitensis Re117 9794189 YP_003915769.1 CDS sucD NC_014550.1 632774 633676 D succinyl-CoA synthetase, which is composed of alpha and beta subunits, catalyzes the interconversion of succinyl-CoA and succinate. Involved in the TCA cycle; succinyl-CoA synthetase subunit alpha 632774..633676 Arthrobacter arilaitensis Re117 9794411 YP_003915770.1 CDS AARI_05710 NC_014550.1 633957 634460 D hypothetical protein 633957..634460 Arthrobacter arilaitensis Re117 9794412 YP_003915771.1 CDS proP NC_014550.1 634550 636082 R identified by similarity to protein SP:P0C0L7 (Escherichia coli). Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. Metabolite:H+ symporter (MHS) family, (Poline/glycine-betaine):(H+/Na+) symporter (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1- carboxymethyl-pyridinium) (subject to osmotic activation) (TC 2.A.1.6.4); proline/betaine transporter complement(634550..636082) Arthrobacter arilaitensis Re117 9796700 YP_003915772.1 CDS AARI_05730 NC_014550.1 636661 636945 R hypothetical protein complement(636661..636945) Arthrobacter arilaitensis Re117 9794226 YP_003915773.1 CDS AARI_05740 NC_014550.1 637108 640455 R possible DNA or RNA helicase; ATP-dependent helicase complement(637108..640455) Arthrobacter arilaitensis Re117 9796701 YP_003915774.1 CDS AARI_05750 NC_014550.1 640542 641732 D hypothetical protein 640542..641732 Arthrobacter arilaitensis Re117 9796702 YP_003915775.1 CDS AARI_05760 NC_014550.1 641795 642898 R 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(641795..642898) Arthrobacter arilaitensis Re117 9796703 YP_003915776.1 CDS AARI_05770 NC_014550.1 642954 643220 R hypothetical protein complement(642954..643220) Arthrobacter arilaitensis Re117 9796704 YP_003915777.1 CDS AARI_05780 NC_014550.1 643296 643478 D hypothetical protein 643296..643478 Arthrobacter arilaitensis Re117 9796705 YP_003915778.1 CDS AARI_05790 NC_014550.1 643633 644196 D match to protein domain PF01381: helix-turn-helix; transcriptional regulator 643633..644196 Arthrobacter arilaitensis Re117 9796706 YP_003915779.1 CDS AARI_05800 NC_014550.1 644334 644750 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 644334..644750 Arthrobacter arilaitensis Re117 9796707 YP_003915780.1 CDS gbh NC_014550.1 645052 646038 D catalyses the following reaction: 4- guanidinobutanoate + H(2)O <=> 4-aminobutanoate + urea. The ortholog found in Arthrobacter sp. KUJ 8602 also acts on D-arginine, 3-guanidinopropionate and L-arginine; guanidinobutyrase 645052..646038 Arthrobacter arilaitensis Re117 9796708 YP_003915781.1 CDS AARI_05820 NC_014550.1 646038 647681 D domain present in thiamine pyrophosphate-requiring enzymes (acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase); thiamine pyrophosphate binding domain-containing protein 646038..647681 Arthrobacter arilaitensis Re117 9793889 YP_003915782.1 CDS AARI_05830 NC_014550.1 647775 647927 R hypothetical protein complement(647775..647927) Arthrobacter arilaitensis Re117 9796709 YP_003915783.1 CDS suhB NC_014550.1 648064 648924 R catalyzes the following reaction: myo-inositol phosphate + H(2)O <=> myo-inositol + phosphate. Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo- inositol bearing more than one phosphate group; inositol-phosphate phosphatase complement(648064..648924) Arthrobacter arilaitensis Re117 9796710 YP_003915784.1 CDS AARI_05850 NC_014550.1 649027 649539 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 649027..649539 Arthrobacter arilaitensis Re117 9794419 YP_003915785.1 CDS AARI_05860 NC_014550.1 649526 651085 D major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z); EmrB/QacA subfamily drug resistance transporter 649526..651085 Arthrobacter arilaitensis Re117 9796711 YP_003915786.1 CDS AARI_05870 NC_014550.1 651131 651850 D identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator 651131..651850 Arthrobacter arilaitensis Re117 9796712 YP_003915787.1 CDS AARI_05880 NC_014550.1 651994 653139 D CoA-transferases catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids; CoA-transferase 651994..653139 Arthrobacter arilaitensis Re117 9796713 YP_003915788.1 CDS AARI_05890 NC_014550.1 653167 654345 D possibly involved in the metabolism of lipids. Match to protein domains PF08028, PF02771 and PF02770. Acyl-CoA dehydrogenases catalyze the alpha,beta- dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase 653167..654345 Arthrobacter arilaitensis Re117 9796714 YP_003915789.1 CDS AARI_05900 NC_014550.1 654377 655834 D catalyses the following reaction: an aldehyde + NAD(+) + H(2)O <=> an acid + NADH; aldehyde dehydrogenase 654377..655834 Arthrobacter arilaitensis Re117 9796715 YP_003915790.1 CDS hbd NC_014550.1 655872 656729 D identified by similarity to protein SP:P52041 (Clostridium acetobutylicum). Reduces 3-hydroxybutanoyl- CoA to acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 655872..656729 Arthrobacter arilaitensis Re117 9796716 YP_003915791.1 CDS AARI_05920 NC_014550.1 656818 657252 R hypothetical protein complement(656818..657252) Arthrobacter arilaitensis Re117 9793946 YP_003915792.1 CDS AARI_05930 NC_014550.1 657350 658435 D hypothetical protein 657350..658435 Arthrobacter arilaitensis Re117 9796717 YP_003915793.1 CDS AARI_05940 NC_014550.1 658438 658905 D match to protein domain PF03061: thioesterase superfamily; thioesterase family domain-containing protein 658438..658905 Arthrobacter arilaitensis Re117 9796718 YP_003915794.1 CDS AARI_05950 NC_014550.1 658969 659823 D identified by match to protein family PF04954. Match to protein domain PF08021. Possibly involved in removal of iron from iron-siderophore complexes; siderophore-interacting protein 658969..659823 Arthrobacter arilaitensis Re117 9796719 YP_003915795.1 CDS alkA NC_014550.1 660154 660996 R DNA repair enzyme that hydrolyzes the deoxyribose N- glycosidic bond to excise various alkylated bases from a damaged DNA polymer; DNA-3-methyladenine glycosylase II complement(660154..660996) Arthrobacter arilaitensis Re117 9796720 YP_003915796.1 CDS tagA NC_014550.1 660998 661591 R DNA repair enzyme that hydrolyzes the deoxyribose N- glycosidic bond to excise various alkylated bases from a damaged DNA polymer; DNA-3-methyladenine glycosylase I complement(660998..661591) Arthrobacter arilaitensis Re117 9793662 YP_003915797.1 CDS AARI_05980 NC_014550.1 661673 662044 D identified by match to PF01022: bacterial regulatory protein, ArsR family. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator 661673..662044 Arthrobacter arilaitensis Re117 9794421 YP_003915798.1 CDS czcD NC_014550.1 662047 662973 D identified by similarity to protein SP:P13512 (Ralstonia metallidurans). Cation diffusion facilitator (CDF) family, Cd2+, Zn2+, Co2+ efflux permease (TC 2.A.4.1. 1). Also binds Cu2+ and Ni2+. Increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt (is considered to be an efflux pump that remove these ions from cells); cobalt-zinc-cadmium resistance protein CzcD 662047..662973 Arthrobacter arilaitensis Re117 9796721 YP_003915799.1 CDS AARI_06000 NC_014550.1 663094 663843 D TCDB: ATP-binding cassette (ABC) superfamily, lipoprotein translocase (LPT) family (TC 3.A.1.125.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), o228 family (members of this family might be involved in a more general lipoprotein releasing mechanism common to all prokaryotes); ABC transporter ATP-binding subunit 663094..663843 Arthrobacter arilaitensis Re117 9793786 YP_003915800.1 CDS AARI_06010 NC_014550.1 663847 666342 D TCDB: ATP-binding cassette (ABC) superfamily, lipoprotein translocase (LPT) family (TC 3.A.1.125.z). ABCISSE: ABC transporter, permease (IM2: 2 IM domains fused into a single polypeptide chain), o228 family (members of this family might be involved in a more general lipoprotein releasing mechanism common to all prokaryotes); ABC transporter inner membrane subunit 663847..666342 Arthrobacter arilaitensis Re117 9796722 YP_003915801.1 CDS AARI_06020 NC_014550.1 666437 666781 D hypothetical protein 666437..666781 Arthrobacter arilaitensis Re117 9796723 YP_003915802.1 CDS AARI_06030 NC_014550.1 666857 670183 R hypothetical protein complement(666857..670183) Arthrobacter arilaitensis Re117 9796724 YP_003915803.1 CDS AARI_06040 NC_014550.1 670187 670873 R hypothetical protein complement(670187..670873) Arthrobacter arilaitensis Re117 9796725 YP_003915804.1 CDS AARI_06050 NC_014550.1 670870 672330 R hypothetical protein complement(670870..672330) Arthrobacter arilaitensis Re117 9796726 YP_003915805.1 CDS AARI_06060 NC_014550.1 672557 673813 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.748 between position 22 and 23; hypothetical protein 672557..673813 Arthrobacter arilaitensis Re117 9796727 YP_003915806.1 CDS AARI_06070 NC_014550.1 673835 677290 R hypothetical protein complement(673835..677290) Arthrobacter arilaitensis Re117 9796728 YP_003915807.1 CDS AARI_06080 NC_014550.1 677368 677688 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(677368..677688) Arthrobacter arilaitensis Re117 9796729 YP_003915808.1 CDS AARI_06090 NC_014550.1 677847 678566 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 677847..678566 Arthrobacter arilaitensis Re117 9796730 YP_003915809.1 CDS AARI_06100 NC_014550.1 678549 679727 R PF03631 (ribonuclease_BN, ribonuclease BN-like family): this family contains integral membrane proteins with 5 to 6 predicted transmembrane spans. The family includes ribonuclease BN, which is involved in tRNA maturation; ribonuclease BN complement(678549..679727) Arthrobacter arilaitensis Re117 9796731 YP_003915810.1 CDS AARI_06110 NC_014550.1 680351 681097 D identified by similarity to protein SP:O86308 (Micrococcus luteus). Bacterial growth factor or cytokine involved in resuscitation of dormant bacteria and stimulation of bacterial growth. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.996 between position 36 and 37; resuscitation-promoting factor 680351..681097 Arthrobacter arilaitensis Re117 9796732 YP_003915811.1 CDS AARI_06120 NC_014550.1 681210 682580 D CoA-transferases catalyse reversible transfer reactions of coenzyme A groups from CoA-thioesters to free acids; CoA-transferase 681210..682580 Arthrobacter arilaitensis Re117 9796733 YP_003915812.1 CDS AARI_06130 NC_014550.1 682577 683416 R match to PF08223: PaaX-like protein C-terminal domain. This family contains proteins that are similar to the product of the paaX gene of Escherichia coli. This protein is involved in the regulation of expression of a group of proteins known to participate in the metabolism of phenylacetic acid; PaaX-like transcriptional regulator complement(682577..683416) Arthrobacter arilaitensis Re117 9796734 YP_003915813.1 CDS kynA NC_014550.1 683406 684272 R catalyses the formation of N-formylkynurenine from L-tryptophan, the first step in the kynurenine pathway (major pathway of tryptophan metabolism); tryptophan 2,3-dioxygenase complement(683406..684272) Arthrobacter arilaitensis Re117 9796735 YP_003915814.1 CDS AARI_06150 NC_014550.1 684423 685106 D identified by match to PF03358. FMN reductase reductase catalyses the following reaction: NAD(P)H + FMN = NAD(P)(+) + FMNH(2); FMN reductase 684423..685106 Arthrobacter arilaitensis Re117 9794026 YP_003915815.1 CDS hpcG NC_014550.1 685347 686132 D identified by similarity to protein SP:P42270 (Escherichia coli). Also named OHED hydratase. Involved in the homoprotocatechuic acid pathway. Catalyses the conversion of 2-oxohept-3-ene-1,7-dioc acid into 2,4- dihydroxyhept-2-ene-1,7-dioic acid; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase 685347..686132 Arthrobacter arilaitensis Re117 9796736 YP_003915816.1 CDS hpcH NC_014550.1 686117 686926 D identified by similarity to protein SP:Q47098 (Escherichia coli). Involved in the homoprotocatechuic acid pathway. Catalyses the conversion of 2,4- dihydroxyhept-2-ene-1,7-dioic acid into succinic semialdehyde and pyruvic acid; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase 686117..686926 Arthrobacter arilaitensis Re117 9793973 YP_003915817.1 CDS AARI_06180 NC_014550.1 687032 688321 D 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein 687032..688321 Arthrobacter arilaitensis Re117 9793974 YP_003915818.1 CDS AARI_06190 NC_014550.1 688340 688981 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.998) with cleavage site probability 0.256 between position 28 and 29; hypothetical protein complement(688340..688981) Arthrobacter arilaitensis Re117 9796737 YP_003915819.1 CDS AARI_06200 NC_014550.1 689083 689613 R hypothetical protein complement(689083..689613) Arthrobacter arilaitensis Re117 9796738 YP_003915820.1 CDS purN NC_014550.1 689764 690333 D catalyses the NADP-dependent decarboxylative reduction of 10-formyltetrahydrofolate into tetrahydrofolate. Involved in DNA synthesis and in de novo purine biosynthesis pathway; phosphoribosylglycinamide formyltransferase 689764..690333 Arthrobacter arilaitensis Re117 9796739 YP_003915821.1 CDS AARI_06220 NC_014550.1 690366 691880 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductase 690366..691880 Arthrobacter arilaitensis Re117 9794254 YP_003915822.1 CDS AARI_06230 NC_014550.1 692048 695068 R EC 3.2.1.24 hydrolyses terminal, non-reducing alpha- D-mannose residues in alpha-D-mannosides. Also hydrolyzes alpha-D-lyxosides and heptopyranosides with the same configuration at C-2, C-3 and C-4 as mannose; alpha-mannosidase complement(692048..695068) Arthrobacter arilaitensis Re117 9796740 YP_003915823.1 CDS AARI_06240 NC_014550.1 695177 695845 R identified by match to protein domain PF00300; phosphoglycerate mutase family protein complement(695177..695845) Arthrobacter arilaitensis Re117 9796741 YP_003915824.1 CDS AARI_06250 NC_014550.1 696055 696624 D match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator 696055..696624 Arthrobacter arilaitensis Re117 9796742 YP_003915825.1 CDS AARI_06260 NC_014550.1 696629 697966 R major facilitator superfamily (MFS), aromatic acid:H+ symporter (AAHS) family (TC 2.A.1.15.z). Members of this family transport compounds such as benzoate, hydroxybenzoate, niacin...; aromatic acid transporter complement(696629..697966) Arthrobacter arilaitensis Re117 9796743 YP_003915826.1 CDS AARI_06270 NC_014550.1 698115 698891 D hypothetical protein 698115..698891 Arthrobacter arilaitensis Re117 9796744 YP_003915827.1 CDS purH NC_014550.1 698989 700659 D catalyses the last two steps in de novo purine biosynthesis. Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) and tetrahydrofolate. IMP cyclohydrolase (EC 3.5.4.10) catalyses the formation of IMP from FAICAR; bifunctional purine biosynthesis protein PurH 698989..700659 Arthrobacter arilaitensis Re117 9796745 YP_003915828.1 CDS AARI_06290 NC_014550.1 700814 700918 R hypothetical protein complement(700814..700918) Arthrobacter arilaitensis Re117 9794250 YP_003915829.1 CDS AARI_06300 NC_014550.1 701018 701149 D hypothetical protein 701018..701149 Arthrobacter arilaitensis Re117 9796746 YP_003915830.1 CDS AARI_06310 NC_014550.1 701254 704163 R match to PF02687: this is a family of predicted permeases and hypothetical transmembrane proteins; permease complement(701254..704163) Arthrobacter arilaitensis Re117 9796747 YP_003915831.1 CDS AARI_06320 NC_014550.1 704166 704891 R TCDB: ATP-binding cassette (ABC) superfamily, lipoprotein translocase (LPT) family (TC 3.A.1.125.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), o228 family (members of this family might be involved in a more general lipoprotein releasing mechanism common to all prokaryotes); ABC transporter ATP-binding subunit complement(704166..704891) Arthrobacter arilaitensis Re117 9796748 YP_003915832.1 CDS AARI_06330 NC_014550.1 704888 705442 R identified by match to protein family PF03551; PadR-like family transcriptional regulator complement(704888..705442) Arthrobacter arilaitensis Re117 9796749 YP_003915833.1 CDS AARI_06340 NC_014550.1 705713 706930 D metal ion (Mn2+-iron) transporter (Nramp) family protein (TC 2.A.55.y.z). The generalized transport reaction catalyzed by Nramp family proteins is: Me2+ (out) + H+ (out) -> Me2+ (in) + H+ (in); divalent metal ion transporter 705713..706930 Arthrobacter arilaitensis Re117 9796750 YP_003915834.1 CDS AARI_06350 NC_014550.1 706944 707753 D hypothetical protein 706944..707753 Arthrobacter arilaitensis Re117 9796751 YP_003915835.1 CDS add NC_014550.1 709022 710014 R catalyzes the irreversible hydrolytic deamination of adenosine to ammonia and inosine, or of desoxyadenosine to ammonia and desoxyinosine; adenosine deaminase complement(709022..710014) Arthrobacter arilaitensis Re117 9797158 YP_003915836.1 CDS AARI_06370 NC_014550.1 710393 711070 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(710393..711070) Arthrobacter arilaitensis Re117 9793657 YP_003915837.1 CDS AARI_06380 NC_014550.1 711123 712862 R enzymes named acetyl-coenzyme A carboxylase (EC 6.4. 1.2), propionyl-coenzyme A carboxylase (EC 6.4.1.3) and acyl-coenzyme A carboxylase are constituted by several types of subunits. Alpha subunits contains the biotin carboxylase (BC, EC 6.3.4.14) and biotin carboxyl carrier protein (BCCP) domains, beta subunits contain the carboxyltransferase (CT) domain. An epsilon subunit is present in some microorganisms; acetyl-/propionyl-coenzyme A carboxylase subunit alpha complement(711123..712862) Arthrobacter arilaitensis Re117 9796753 YP_003915838.1 CDS AARI_06390 NC_014550.1 712871 714475 R identified by match to PF02626 and PF02682. EC 3.5. 1.24 may be involved in the degradation of urea, together with EC 6.3.4.6, or in cyanuric acid metabolism; allophanate hydrolase complement(712871..714475) Arthrobacter arilaitensis Re117 9796754 YP_003915839.1 CDS AARI_06400 NC_014550.1 714472 715230 R identified by match to protein family PF03746. This family includes LamB. The lam locus of Aspergillus nidulans consists of two divergently transcribed genes, lamA and lamB, involved in the utilisation of lactams such as 2-pyrrolidinone; LamB/YcsF family protein complement(714472..715230) Arthrobacter arilaitensis Re117 9796755 YP_003915840.1 CDS AARI_06410 NC_014550.1 715438 715584 R hypothetical protein complement(715438..715584) Arthrobacter arilaitensis Re117 9796756 YP_003915841.1 CDS fhs NC_014550.1 715746 717428 R catalyses the following reaction: ATP + formate + tetrahydrofolate => ADP + phosphate + 10- formyltetrahydrofolate; formate--tetrahydrofolate ligase complement(715746..717428) Arthrobacter arilaitensis Re117 9796757 YP_003915842.1 CDS AARI_06430 NC_014550.1 717764 719224 R major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z). Identified by match to protein family TIGR00711; EmrB/QacA subfamily drug resistance transporter complement(717764..719224) Arthrobacter arilaitensis Re117 9793849 YP_003915843.1 CDS AARI_06440 NC_014550.1 719373 719966 D match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator 719373..719966 Arthrobacter arilaitensis Re117 9796839 YP_003915844.1 CDS icd NC_014550.1 720180 722402 D involved in the TCA cycle. Catalyses the interconversion of isocitrate and 2-oxoglutarate. Oxalosuccinate can also be used as a substrate; isocitrate dehydrogenase 720180..722402 Arthrobacter arilaitensis Re117 9796840 YP_003915845.1 CDS AARI_06460 NC_014550.1 722536 722811 D hypothetical protein 722536..722811 Arthrobacter arilaitensis Re117 9793996 YP_003915846.1 CDS AARI_06470 NC_014550.1 722798 723535 D hypothetical protein 722798..723535 Arthrobacter arilaitensis Re117 9796841 YP_003915847.1 CDS AARI_06480 NC_014550.1 723758 724252 R hypothetical protein complement(723758..724252) Arthrobacter arilaitensis Re117 9796842 YP_003915848.1 CDS AARI_06490 NC_014550.1 724268 724726 R hypothetical protein complement(724268..724726) Arthrobacter arilaitensis Re117 9796843 YP_003915849.1 CDS AARI_06500 NC_014550.1 724762 724911 D hypothetical protein 724762..724911 Arthrobacter arilaitensis Re117 9796844 YP_003915850.1 CDS AARI_06510 NC_014550.1 724972 725997 D match to protein domain PF00075 (RNase H). This domain is often associated with reverse transcriptases (important enzyme in retroviral replication cycle); reverse transcriptase 724972..725997 Arthrobacter arilaitensis Re117 9796845 YP_003915851.1 CDS dgt NC_014550.1 726071 727603 R dGTPase catalyses the formation of deoxyguanosine from dGTP. It is involved in purine metabolism; dGTPase complement(726071..727603) Arthrobacter arilaitensis Re117 9796846 YP_003915852.1 CDS AARI_06530 NC_014550.1 727738 728766 R D-isomer specific 2-hydroxyacid dehydrogenase family protein complement(727738..728766) Arthrobacter arilaitensis Re117 9793809 YP_003915853.1 CDS AARI_06540 NC_014550.1 728816 729019 D hypothetical protein 728816..729019 Arthrobacter arilaitensis Re117 9796847 YP_003915854.1 CDS AARI_06550 NC_014550.1 729063 729632 R hypothetical protein complement(729063..729632) Arthrobacter arilaitensis Re117 9796848 YP_003915855.1 CDS AARI_06560 NC_014550.1 729916 731214 R match to PF00196: bacterial regulatory proteins, luxR family. This domain is a DNA-binding, helix-turn- helix (HTH) domain of about 65 amino acids, present in transcription regulators of the LuxR/FixJ family of response regulators; hypothetical protein complement(729916..731214) Arthrobacter arilaitensis Re117 9796849 YP_003915856.1 CDS rmpB NC_014550.1 731376 731972 D identified by similarity to protein SP:Q9LBW5 (Mycobacterium gastri). Catalyzes the isomerization of the D-arabino-3-hexulose 6-phosphate into fructose 6-phosphate in microorganisms that can use formaldehyde as a carbon source (ribulose monophosphate pathway of formaldehyde fixation); 3-hexulose-6-phosphate isomerase 731376..731972 Arthrobacter arilaitensis Re117 9796850 YP_003915857.1 CDS rmpA NC_014550.1 732030 732653 D identified by similarity to protein SP:Q9LBW4 (Mycobacterium gastri). Catalyzes the formation of D- arabino-3-hexulose-6-phosphate from D-ribulose 5-phosphate and formaldehyde in microorganisms that can use formaldehyde as a carbon source (ribulose monophosphate pathway of formaldehyde fixation); 3-hexulose-6-phosphate synthase 732030..732653 Arthrobacter arilaitensis Re117 9794303 YP_003915858.1 CDS AARI_06640 NC_014550.1 734827 735510 R cd00038: effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription; Crp/Fnr family transcriptional regulator complement(734827..735510) Arthrobacter arilaitensis Re117 9796855 YP_003915859.1 CDS copZ NC_014550.1 735681 735920 D chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-transporting ATPase CopA. Identified by similarity to protein SP:O32221 (Bacillus subtilis); copper chaperone CopZ 735681..735920 Arthrobacter arilaitensis Re117 9796856 YP_003915860.1 CDS copA NC_014550.1 736015 738018 D involved in copper export. Forms an heterodimer with CopZ during the transfer of Cu(+). TCDB: P-type ATPase (P-ATPase) superfamily (TC 3.A.3.y.z). Identified by similarity to protein SP:O32220 (Bacillus subtilis); copper-exporting ATPase CopA 736015..738018 Arthrobacter arilaitensis Re117 9793756 YP_003915861.1 CDS AARI_06670 NC_014550.1 738124 738549 D presence of one conserved barrel domain of the cupin superfamily (PF07883); barrel domain-containing protein 738124..738549 Arthrobacter arilaitensis Re117 9793755 YP_003915862.1 CDS AARI_06680 NC_014550.1 739016 739891 R PF02012: BNR/Asp-box repeats. These repeats are found in a variety of non-homologous proteins, including bacterial ribonucleases, sulphite oxidases, reelin, netrins, sialidases, neuraminidases, some lipoprotein receptors, and a variety of glycosyl hydrolases. Similar to protein SP:Q6SK52 (Arthrobacter aurescens plasmid); hypothetical protein complement(739016..739891) Arthrobacter arilaitensis Re117 9796857 YP_003915863.1 CDS AARI_06690 NC_014550.1 739976 740581 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.520 between position 25 and 26. Similar to protein SP:A1RCQ1 (Arthrobacter aurescens plasmid); hypothetical protein complement(739976..740581) Arthrobacter arilaitensis Re117 9796858 YP_003915864.1 CDS AARI_06700 NC_014550.1 740703 741176 R 2 transmembrane helices predicted by TMHMM2.0. Similar to protein SP:A1RCQ0 (Arthrobacter aurescens plasmid); hypothetical protein complement(740703..741176) Arthrobacter arilaitensis Re117 9796859 YP_003915865.1 CDS AARI_06710 NC_014550.1 741276 743447 R P-type ATPase (P-ATPase) superfamily (TC 3.A.3.y.z). Involved in export of cations; cation-transporting ATPase complement(741276..743447) Arthrobacter arilaitensis Re117 9796860 YP_003915866.1 CDS AARI_06720 NC_014550.1 743608 744036 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 743608..744036 Arthrobacter arilaitensis Re117 9796861 YP_003915867.1 CDS AARI_06740 NC_014550.1 744871 746811 R TCDB: P-type ATPase (P-ATPase) superfamily (TC 3.A. 3.y.z). Possibly involved in export of cations; cation-transporting ATPase complement(744871..746811) Arthrobacter arilaitensis Re117 9796863 YP_003915868.1 CDS AARI_06750 NC_014550.1 746808 747176 R identified by match to PF01022: bacterial regulatory protein, ArsR family. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator complement(746808..747176) Arthrobacter arilaitensis Re117 9796864 YP_003915869.1 CDS AARI_06760 NC_014550.1 747392 747637 D hypothetical protein 747392..747637 Arthrobacter arilaitensis Re117 9796865 YP_003915870.1 CDS AARI_06770 NC_014550.1 747634 748434 D identified by match to PF02661: Fic protein family. cAMP may be a regulation factor in cell division of some bacteria. The Fic (filamentation induced by cAMP) protein is involved in the synthesis of PAB or folate. It would appear that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism and in these organisms cell division could be controlled by coordination of cAMP, Fic and Fts proteins; Fic family protein 747634..748434 Arthrobacter arilaitensis Re117 9796866 YP_003915871.1 CDS AARI_06780 NC_014550.1 748431 749105 D match to PF00239 and PF02796. Possibly involved in site-specific recombination of DNA; resolvase 748431..749105 Arthrobacter arilaitensis Re117 9796867 YP_003915872.1 CDS AARI_06790 NC_014550.1 749402 749797 R hypothetical protein complement(749402..749797) Arthrobacter arilaitensis Re117 9796868 YP_003915873.1 CDS AARI_06800 NC_014550.1 750004 750459 D identified by match to protein family PF05713: bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis- active site of a mobilising plasmid, the origin of transfer (oriT) region; mobilisation protein 750004..750459 Arthrobacter arilaitensis Re117 9796869 YP_003915874.1 CDS AARI_06810 NC_014550.1 750456 752171 D identified by match to protein family PF03432: Relaxase/Mobilisation nuclease domain. Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation; mobilisation protein 750456..752171 Arthrobacter arilaitensis Re117 9796870 YP_003915875.1 CDS AARI_06820 NC_014550.1 752187 753047 D similar to Arthrobacter plasmidic proteins; hypothetical protein 752187..753047 Arthrobacter arilaitensis Re117 9796871 YP_003915876.1 CDS AARI_06830 NC_014550.1 753359 754717 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.990 between position 30 and 31; hypothetical protein 753359..754717 Arthrobacter arilaitensis Re117 9796872 YP_003915877.1 CDS AARI_06840 NC_014550.1 754792 755199 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 754792..755199 Arthrobacter arilaitensis Re117 9796873 YP_003915878.1 CDS AARI_06850 NC_014550.1 755360 755722 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(755360..755722) Arthrobacter arilaitensis Re117 9796874 YP_003915879.1 CDS AARI_06860 NC_014550.1 755757 756506 R hypothetical protein complement(755757..756506) Arthrobacter arilaitensis Re117 9796875 YP_003915880.1 CDS AARI_06890 NC_014550.1 758702 759310 R acyl-CoA acyltransferase domain-containing protein complement(758702..759310) Arthrobacter arilaitensis Re117 9796878 YP_003915881.1 CDS AARI_06900 NC_014550.1 759511 760632 R hypothetical protein complement(759511..760632) Arthrobacter arilaitensis Re117 9796879 YP_003915882.1 CDS AARI_06910 NC_014550.1 761249 761773 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(761249..761773) Arthrobacter arilaitensis Re117 9796880 YP_003915883.1 CDS AARI_06920 NC_014550.1 762001 762849 R IPR001478; PDZ domains are found in diverse signaling proteins in bacteria, yeasts, plants, insects and vertebrates; PDZ domain-containing protein complement(762001..762849) Arthrobacter arilaitensis Re117 9796881 YP_003915884.1 CDS trt NC_014550.1 763759 765096 D identified by similarity to protein SP:Q6DKY2 (Bacillus stearothermophilus). Heat-stable reverse transcriptase. Possible group II intron associated protein; reverse transcriptase/maturase 763759..765096 Arthrobacter arilaitensis Re117 9796882 YP_003915885.1 CDS AARI_06940 NC_014550.1 765331 766038 D hypothetical protein 765331..766038 Arthrobacter arilaitensis Re117 9794474 YP_003915886.1 CDS AARI_34570 NC_014550.1 766062 767339 R transposase of ISAar15, ISL3 family complement(766062..767339) Arthrobacter arilaitensis Re117 9796883 YP_003915887.1 CDS AARI_34580 NC_014550.1 767420 768499 R transposase of ISAar16, IS110 family complement(767420..768499) Arthrobacter arilaitensis Re117 9797159 YP_003915888.1 CDS AARI_06950 NC_014550.1 768891 769151 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 768891..769151 Arthrobacter arilaitensis Re117 9797160 YP_003915889.1 CDS AARI_06960 NC_014550.1 769232 769774 R identified by match to PF01613; flavin reductase-like domain protein complement(769232..769774) Arthrobacter arilaitensis Re117 9796884 YP_003915890.1 CDS metE NC_014550.1 769767 770807 R final step in methionine synthesis; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase complement(769767..770807) Arthrobacter arilaitensis Re117 9796885 YP_003915891.1 CDS AARI_06980 NC_014550.1 770826 771818 R hypothetical protein complement(770826..771818) Arthrobacter arilaitensis Re117 9794070 YP_003915892.1 CDS AARI_06990 NC_014550.1 771941 773071 D identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator 771941..773071 Arthrobacter arilaitensis Re117 9796886 YP_003915893.1 CDS AARI_07000 NC_014550.1 773295 774608 D catalyses several reactions, including the formation of L-homocysteine from O-acetyl-L-homoserine and H2S, and the formation of L-methionine from O-acetyl-L- homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 773295..774608 Arthrobacter arilaitensis Re117 9796887 YP_003915894.1 CDS metB NC_014550.1 774605 775828 D catalyzes the conversion of cysteine and succinyl- homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms; cystathionine gamma-synthase 774605..775828 Arthrobacter arilaitensis Re117 9796888 YP_003915895.1 CDS AARI_07030 NC_014550.1 776416 777030 R match to PF00132: Bacterial transferase hexapeptide repeat. A number of different transferase protein families contain this repeat, such as galactoside acetyltransferase- like proteins, the gamma-class of carbonic anhydrases, and tetrahydrodipicolinate-N-succinlytransferases; transferase complement(776416..777030) Arthrobacter arilaitensis Re117 9796889 YP_003915896.1 CDS AARI_07040 NC_014550.1 777083 777448 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(777083..777448) Arthrobacter arilaitensis Re117 9796890 YP_003915897.1 CDS purU NC_014550.1 777451 778293 R catalyses the following reaction: 10- formyltetrahydrofolate + H(2)O <=> formate + tetrahydrofolate; formyltetrahydrofolate deformylase complement(777451..778293) Arthrobacter arilaitensis Re117 9796891 YP_003915898.1 CDS folD NC_014550.1 779557 780420 D methylenetetrahydrofolate dehydrogenase (EC 1.5.1. 5) catalyses the following reaction: 5,10- methylenetetrahydrofolate + NADP(+) <=> 5,10- methenyltetrahydrofolate + NADPH. Methylenetetrahydrofolate cyclohydrolase (EC 3.5.4.9) catalyses the following reaction: 5,10- methenyltetrahydrofolate + H(2)O <=> 10- formyltetrahydrofolate methenyltetrahydrofolate cyclohydrolase; bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 779557..780420 Arthrobacter arilaitensis Re117 9796892 YP_003915899.1 CDS AARI_07080 NC_014550.1 780559 781944 R major facilitator superfamily (MFS), metabolite:H+ symporter (MHS) family (TC 2.A.1.6.z); MFS superfamily transporter complement(780559..781944) Arthrobacter arilaitensis Re117 9793859 YP_003915900.1 CDS AARI_07090 NC_014550.1 782072 782971 D identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator 782072..782971 Arthrobacter arilaitensis Re117 9796893 YP_003915901.1 CDS AARI_07100 NC_014550.1 783004 783360 D hypothetical protein 783004..783360 Arthrobacter arilaitensis Re117 9796894 YP_003915902.1 CDS AARI_07110 NC_014550.1 783308 783970 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(783308..783970) Arthrobacter arilaitensis Re117 9796895 YP_003915903.1 CDS AARI_07120 NC_014550.1 783967 785130 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(783967..785130) Arthrobacter arilaitensis Re117 9796896 YP_003915904.1 CDS AARI_07130 NC_014550.1 785240 786022 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 785240..786022 Arthrobacter arilaitensis Re117 9796897 YP_003915905.1 CDS AARI_07140 NC_014550.1 786092 786589 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 786092..786589 Arthrobacter arilaitensis Re117 9796898 YP_003915906.1 CDS AARI_07150 NC_014550.1 786692 787531 D removes the damaged DNA at cytosines and guanines by cleaving on the 3 -side of the apurinic/apyrimidinic sites; exodeoxyribonuclease III 786692..787531 Arthrobacter arilaitensis Re117 9796899 YP_003915907.1 CDS trpS NC_014550.1 787540 788556 D activates tryptophan and transfers it to tRNA(Trp) as the first step in protein biosynthesis; tryptophan--tRNA ligase 787540..788556 Arthrobacter arilaitensis Re117 9796900 YP_003915908.1 CDS AARI_07170 NC_014550.1 788556 789068 D match to PF02834. Corresponds to a number of known and predicted phosphoesterases, including bacterial and archaeal 2 ,5 RNA ligases. The physiological substrate(s) in prokaryotes may include small 2 ,5 -link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles; 2',5' RNA ligase 788556..789068 Arthrobacter arilaitensis Re117 9794473 YP_003915909.1 CDS AARI_07180 NC_014550.1 789114 790568 R decomposes hydrogen peroxide to molecular oxygen and water. Its main function is to protect cells from the toxic effects of hydrogen peroxide; catalase complement(789114..790568) Arthrobacter arilaitensis Re117 9796901 YP_003915910.1 CDS AARI_34590 NC_014550.1 791662 792939 R transposase of ISAar15, ISL3 family complement(791662..792939) Arthrobacter arilaitensis Re117 9796902 YP_003915911.1 CDS AARI_34600 NC_014550.1 793020 794099 R transposase of ISAar16, IS110 family complement(793020..794099) Arthrobacter arilaitensis Re117 9797161 YP_003915912.1 CDS AARI_34610 NC_014550.1 795611 796918 R transposase of ISAar19, ISL3 family complement(795611..796918) Arthrobacter arilaitensis Re117 9797162 YP_003915913.1 CDS AARI_07190 NC_014550.1 798815 799813 D 9 transmembrane helices predicted by TMHMM2.0; hypothetical protein 798815..799813 Arthrobacter arilaitensis Re117 9793405 YP_003915914.1 CDS sdhB NC_014550.1 799879 800661 R the succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle; succinate dehydrogenase iron-sulfur subunit complement(799879..800661) Arthrobacter arilaitensis Re117 9796903 YP_003915915.1 CDS sdhA NC_014550.1 800661 802448 R the succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle; succinate dehydrogenase flavoprotein subunit complement(800661..802448) Arthrobacter arilaitensis Re117 9794383 YP_003915916.1 CDS sdhD NC_014550.1 802506 802949 R the succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle; succinate dehydrogenase membrane subunit complement(802506..802949) Arthrobacter arilaitensis Re117 9794381 YP_003915917.1 CDS sdhC NC_014550.1 802953 803333 R the succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle; succinate dehydrogenase membrane subunit complement(802953..803333) Arthrobacter arilaitensis Re117 9794385 YP_003915918.1 CDS manC NC_014550.1 803613 804728 D catalyses the following reaction: GDP + alpha-D- mannose 1-phosphate <=> phosphate + GDP-mannose. Participates in fructose and mannose metabolism; mannose-1-phosphate guanylyltransferase 803613..804728 Arthrobacter arilaitensis Re117 9794384 YP_003915919.1 CDS betT NC_014550.1 804878 807022 D identified by similarity to protein SP:P0ABC9 (Escherichia coli). Betaine/carnitine/choline fransporter (BCCT) family, choline:H+ symporter (TC 2.A.15.3.1). Involved in the osmoregulatory choline-glycine betaine pathway (choline uptake); high-affinity choline transport protein 804878..807022 Arthrobacter arilaitensis Re117 9794057 YP_003915920.1 CDS betB NC_014550.1 807019 808545 D involved in the synthesis of the osmoprotectant betaine; betaine-aldehyde dehydrogenase 807019..808545 Arthrobacter arilaitensis Re117 9793712 YP_003915921.1 CDS codA NC_014550.1 808563 810134 D catalyzes the following reaction: choline + O2 <=> betaine aldehyde + H2O2. Involved in the synthesis of the osmoprotectant betaine; choline oxidase 808563..810134 Arthrobacter arilaitensis Re117 9793711 YP_003915922.1 CDS AARI_07280 NC_014550.1 810281 811477 D metal-dependent amidase/aminoacylase/carboxypeptidase 810281..811477 Arthrobacter arilaitensis Re117 9793754 YP_003915923.1 CDS AARI_07290 NC_014550.1 811766 812854 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, binding protein (BP), MOS-family (monosaccharides: pentoses and hexoses); sugar ABC transporter substrate-binding protein 811766..812854 Arthrobacter arilaitensis Re117 9796904 YP_003915924.1 CDS AARI_07300 NC_014550.1 812992 814590 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, fused ATP- binding protein (ABC2), MOS-family (monosaccharides: pentoses and hexoses); sugar ABC transporter ATP-binding subunit 812992..814590 Arthrobacter arilaitensis Re117 9796905 YP_003915925.1 CDS AARI_07310 NC_014550.1 814587 815792 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, permease (IM), MOS-family (monosaccharides: pentoses and hexoses); sugar ABC transporter inner membrane subunit 814587..815792 Arthrobacter arilaitensis Re117 9796906 YP_003915926.1 CDS AARI_07320 NC_014550.1 815789 817060 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, permease (IM), MOS-family (monosaccharides: pentoses and hexoses); sugar ABC transporter inner membrane subunit 815789..817060 Arthrobacter arilaitensis Re117 9796907 YP_003915927.1 CDS cdd NC_014550.1 817070 817480 D catalyzes the hydrolysis of cytidine into uridine and ammonia; cytidine deaminase 817070..817480 Arthrobacter arilaitensis Re117 9796908 YP_003915928.1 CDS deoA NC_014550.1 817524 818837 D catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate. This enzyme regulates the availability of thymidine and is therefore essential to nucleic acid metabolism; thymidine phosphorylase 817524..818837 Arthrobacter arilaitensis Re117 9793732 YP_003915929.1 CDS AARI_07350 NC_014550.1 819121 819795 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 819121..819795 Arthrobacter arilaitensis Re117 9793802 YP_003915930.1 CDS add NC_014550.1 819887 821080 D catalyzes the irreversible hydrolytic deamination of adenosine to ammonia and inosine, or of desoxyadenosine to ammonia and desoxyinosine; adenosine deaminase 819887..821080 Arthrobacter arilaitensis Re117 9796909 YP_003915931.1 CDS AARI_07370 NC_014550.1 821165 822655 R identified by match to protein family PF00171; aldehyde dehydrogenase family protein complement(821165..822655) Arthrobacter arilaitensis Re117 9793658 YP_003915932.1 CDS AARI_07380 NC_014550.1 822766 823464 D match to protein domain PF03819. In Escherichia coli, MazG was characterized as a nucleoside triphosphate pyrophosphohydrolase which can hydrolyze all eight of the canonical ribo- and deoxynucleoside triphosphates to their respective monophosphates and PPi, with a preference for deoxynucleotides; MazG nucleotide pyrophosphohydrolase domain-containing protein 822766..823464 Arthrobacter arilaitensis Re117 9796910 YP_003915933.1 CDS eno NC_014550.1 823557 824837 D other names: 2-phosphoglycerate dehydratase, 2- phospho-D-glycerate hydro-lyase. Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate; enolase 823557..824837 Arthrobacter arilaitensis Re117 9796911 YP_003915934.1 CDS AARI_07400 NC_014550.1 824962 825801 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 824962..825801 Arthrobacter arilaitensis Re117 9793835 YP_003915935.1 CDS AARI_07410 NC_014550.1 825831 826532 D hypothetical protein 825831..826532 Arthrobacter arilaitensis Re117 9796912 YP_003915936.1 CDS AARI_07420 NC_014550.1 826532 827458 D identified by match to protein family PF02541. Similar to exopolyphosphatase (Ppx, EC 3.6.1.11) and guanosine pentaphosphate phospho-hydrolase (GppA, EC 3.6.1. 40) proteins; Ppx/GppA phosphatase family protein 826532..827458 Arthrobacter arilaitensis Re117 9796913 YP_003915937.1 CDS AARI_07430 NC_014550.1 827493 828998 D identified by match to PF00082. Subtilases are a family of serine proteases. The vast majority of the family are endopeptidases. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.974 between position 38 and 39. 1 transmembrane helice predicted by TMHMM2.0 after the signal peptide; subtilase 827493..828998 Arthrobacter arilaitensis Re117 9796914 YP_003915938.1 CDS ndh NC_014550.1 829189 830556 D NADH dehydrogenase catalyzes the following reaction: NADH + acceptor <=> NAD(+) + reduced acceptor; NADH dehydrogenase 829189..830556 Arthrobacter arilaitensis Re117 9796915 YP_003915939.1 CDS AARI_07450 NC_014550.1 831054 831860 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 831054..831860 Arthrobacter arilaitensis Re117 9793600 YP_003915940.1 CDS AARI_07460 NC_014550.1 832073 833512 D amino acid-polyamine-organocation (APC) superfamily (TC 2.A.3.y.z); amino acid transporter 832073..833512 Arthrobacter arilaitensis Re117 9796916 YP_003915941.1 CDS AARI_07470 NC_014550.1 833692 835023 D match to protein family PF01594; permease 833692..835023 Arthrobacter arilaitensis Re117 9796917 YP_003915942.1 CDS ilvA NC_014550.1 835027 836298 D catalyzes the conversion of threonine into 2- oxobutanoate. Involved in isoleucine biosynthesis. The enzyme from a number of sources also acts on L-serine; threonine ammonia-lyase 835027..836298 Arthrobacter arilaitensis Re117 9796918 YP_003915943.1 CDS greA NC_014550.1 836371 836868 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; transcription elongation factor GreA complement(836371..836868) Arthrobacter arilaitensis Re117 9794002 YP_003915944.1 CDS AARI_07500 NC_014550.1 837158 837634 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(837158..837634) Arthrobacter arilaitensis Re117 9793935 YP_003915945.1 CDS AARI_07510 NC_014550.1 837768 838685 D LmbE-like protein 837768..838685 Arthrobacter arilaitensis Re117 9796919 YP_003915946.1 CDS AARI_07520 NC_014550.1 838729 839010 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 838729..839010 Arthrobacter arilaitensis Re117 9797001 YP_003915947.1 CDS AARI_07530 NC_014550.1 839043 841157 D hypothetical protein 839043..841157 Arthrobacter arilaitensis Re117 9797002 YP_003915948.1 CDS uppS1 NC_014550.1 841275 842036 D generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide; di-trans,poly-cis-decaprenylcistransferase 841275..842036 Arthrobacter arilaitensis Re117 9797003 YP_003915949.1 CDS AARI_07550 NC_014550.1 842293 843609 D identified by match to protein family PF02562: PhoH, PhoH-like protein. PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation; PhoH-like protein 842293..843609 Arthrobacter arilaitensis Re117 9794492 YP_003915950.1 CDS AARI_07560 NC_014550.1 843606 844424 R hypothetical protein complement(843606..844424) Arthrobacter arilaitensis Re117 9797004 YP_003915951.1 CDS AARI_07570 NC_014550.1 844508 845011 D match to PF01478: Type IV leader peptidase family. This group of aspartic endopeptidases belong to MEROPS peptidase family A24 (type IV prepilin peptidase family, clan AD), subfamily A24A. Possibly involved in protein secretion; leader peptidase 844508..845011 Arthrobacter arilaitensis Re117 9797005 YP_003915952.1 CDS AARI_07580 NC_014550.1 845016 845483 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 845016..845483 Arthrobacter arilaitensis Re117 9797006 YP_003915953.1 CDS fumC NC_014550.1 846808 848220 R catalyzes the reversible hydration of fumarate to L- malate. Involved in the TCA cycle; fumarate hydratase class II complement(846808..848220) Arthrobacter arilaitensis Re117 9797009 YP_003915954.1 CDS AARI_07620 NC_014550.1 848351 848980 R carbonate dehydratases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They are ubiquitous enzymes involved in fundamental processes like respiration, pH homeostasis and ion transport; carbonate dehydratase complement(848351..848980) Arthrobacter arilaitensis Re117 9793872 YP_003915955.1 CDS AARI_07630 NC_014550.1 849072 849488 D hypothetical protein 849072..849488 Arthrobacter arilaitensis Re117 9797010 YP_003915956.1 CDS AARI_07640 NC_014550.1 850571 851245 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(850571..851245) Arthrobacter arilaitensis Re117 9793406 YP_003915957.1 CDS glpX NC_014550.1 851402 852436 D catalyzes the hydrolysis of fructose 1,6- bisphosphate to fructose 6-phosphate. Involved in gluconeogenesis; fructose-bisphosphatase, class II 851402..852436 Arthrobacter arilaitensis Re117 9797012 YP_003915958.1 CDS manA NC_014550.1 852541 853749 R catalyzes the interconversion of mannose-6- phosphate and fructose-6-phosphate. In prokaryotes, it is involved in a variety of pathways including capsular polysaccharide biosynthesis and D-mannose metabolism; class I mannose-6-phosphate isomerase complement(852541..853749) Arthrobacter arilaitensis Re117 9793915 YP_003915959.1 CDS AARI_07670 NC_014550.1 853817 855424 R cell envelope-related transcriptional attenuator complement(853817..855424) Arthrobacter arilaitensis Re117 9794055 YP_003915960.1 CDS purE NC_014550.1 855442 855972 R phosphoribosylaminoimidazole carboxylase catalyses the sixth step of de novo purine biosynthesis, the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4- imidazole-carboxylate (AIR); phosphoribosylaminoimidazole carboxylase catalytic subunit complement(855442..855972) Arthrobacter arilaitensis Re117 9797013 YP_003915961.1 CDS purK NC_014550.1 856046 857158 R phosphoribosylaminoimidazole carboxylase catalyses the sixth step of de novo purine biosynthesis, the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4- imidazole-carboxylate (AIR); phosphoribosylaminoimidazole carboxylase ATPase subunit complement(856046..857158) Arthrobacter arilaitensis Re117 9794248 YP_003915962.1 CDS AARI_07700 NC_014550.1 857383 857952 D identified by match to protein family PF04138. Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides; GtrA-like protein 857383..857952 Arthrobacter arilaitensis Re117 9794251 YP_003915963.1 CDS AARI_07710 NC_014550.1 857949 858677 R hypothetical protein complement(857949..858677) Arthrobacter arilaitensis Re117 9797014 YP_003915964.1 CDS AARI_07720 NC_014550.1 858976 859500 D identified by match to protein family PF02467. WhiB is a transcription factor in Actinobacteria, required for differentiation and sporulation; WhiB family transcriptional regulator 858976..859500 Arthrobacter arilaitensis Re117 9797015 YP_003915965.1 CDS AARI_07730 NC_014550.1 859569 862970 D match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 859569..862970 Arthrobacter arilaitensis Re117 9797016 YP_003915966.1 CDS AARI_07740 NC_014550.1 862970 865567 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 862970..865567 Arthrobacter arilaitensis Re117 9797017 YP_003915967.1 CDS AARI_07750 NC_014550.1 865594 866523 D identified by match to protein family PF02628. One member of this family, CtaA, is required for cytochrome aa3 biosynthesis in Bacillus subtilis; cytochrome oxidase assembly protein 865594..866523 Arthrobacter arilaitensis Re117 9797018 YP_003915968.1 CDS AARI_07760 NC_014550.1 866536 866994 R hypothetical protein complement(866536..866994) Arthrobacter arilaitensis Re117 9797019 YP_003915969.1 CDS AARI_07770 NC_014550.1 867027 867254 D hypothetical protein 867027..867254 Arthrobacter arilaitensis Re117 9797020 YP_003915970.1 CDS AARI_07780 NC_014550.1 867251 867487 D hypothetical protein 867251..867487 Arthrobacter arilaitensis Re117 9797021 YP_003915971.1 CDS AARI_07790 NC_014550.1 867698 869299 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 867698..869299 Arthrobacter arilaitensis Re117 9797022 YP_003915972.1 CDS AARI_07800 NC_014550.1 869369 871210 R activates fatty acids by binding to coenzyme A. Possibly involved in the synthesis of cellular lipids or their degradation via beta-oxidation; fatty-acid--CoA ligase complement(869369..871210) Arthrobacter arilaitensis Re117 9797023 YP_003915973.1 CDS AARI_07810 NC_014550.1 871289 872899 R identified by match to protein family PF02366. Transfers mannosyl residues to the hydroxy of serine or threonine residues, producing cell-wall mannoproteins; dolichyl-phosphate-mannose-protein mannosyltransferase complement(871289..872899) Arthrobacter arilaitensis Re117 9797024 YP_003915974.1 CDS AARI_07820 NC_014550.1 872968 873828 D tetrapyrrole methylase 872968..873828 Arthrobacter arilaitensis Re117 9797025 YP_003915975.1 CDS gabD NC_014550.1 873967 875454 D succinate-semialdehyde dehydrogenase (NAD(P)(+)) reduces succinate semialdehyde into succinate. Involved in the degradation of gamma-aminobutyrate; succinate-semialdehyde dehydrogenase 873967..875454 Arthrobacter arilaitensis Re117 9797026 YP_003915976.1 CDS AARI_07840 NC_014550.1 875523 877940 R identified by match to protein domain PF01841: Transglutaminase-like superfamily. Most microbial homologues of the transglutaminases are probably proteases. 8 transmembrane helices predicted by TMHMM2.0; transglutaminase complement(875523..877940) Arthrobacter arilaitensis Re117 9793875 YP_003915977.1 CDS AARI_07850 NC_014550.1 877930 879255 R hypothetical protein complement(877930..879255) Arthrobacter arilaitensis Re117 9797027 YP_003915978.1 CDS AARI_07860 NC_014550.1 879266 880228 R identified by match to protein family PIRSF002849. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes; AAA-type ATPase enzymatic complex assembly chaperone complement(879266..880228) Arthrobacter arilaitensis Re117 9797028 YP_003915979.1 CDS AARI_07870 NC_014550.1 880437 881393 D identified by match to protein family PF01026; TatD-related deoxyribonuclease 880437..881393 Arthrobacter arilaitensis Re117 9797029 YP_003915980.1 CDS AARI_07880 NC_014550.1 881652 882815 D match to protein domains PF03990 (DUF348 domain of unknown function), PF07501 (G5 domain) and PF06737 (transglycosylase-like domain). The PF07501 domain is also found in proteins involved in metabolism of bacterial cell walls suggesting this domain may have an adhesive function; cell wall function protein 881652..882815 Arthrobacter arilaitensis Re117 9797030 YP_003915981.1 CDS ksgA NC_014550.1 882913 883800 D specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3 prime-end of 16S rRNA in the 30S particle. Its inactivation leads to kasugamycin resistance; dimethyladenosine transferase 882913..883800 Arthrobacter arilaitensis Re117 9797031 YP_003915982.1 CDS ispE NC_014550.1 883803 884735 D forms part of the non-mevalonate pathway for terpenoid biosynthesis; 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase 883803..884735 Arthrobacter arilaitensis Re117 9794025 YP_003915983.1 CDS AARI_07910 NC_014550.1 884890 886260 D FAD-dependent oxidoreductase 884890..886260 Arthrobacter arilaitensis Re117 9794012 YP_003915984.1 CDS AARI_07920 NC_014550.1 886292 886471 D hypothetical protein 886292..886471 Arthrobacter arilaitensis Re117 9797032 YP_003915985.1 CDS AARI_07930 NC_014550.1 886464 886988 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 886464..886988 Arthrobacter arilaitensis Re117 9797033 YP_003915986.1 CDS AARI_07940 NC_014550.1 886975 887253 R hypothetical protein complement(886975..887253) Arthrobacter arilaitensis Re117 9797034 YP_003915987.1 CDS AARI_07950 NC_014550.1 887363 889153 R TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-2 (Drug RA2) family (TC 3.A.1.121.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family, ARE-subfamily (antibiotic resistance); drug resistance ATP-binding protein complement(887363..889153) Arthrobacter arilaitensis Re117 9797035 YP_003915988.1 CDS glmU NC_014550.1 889558 891009 D glucosamine-1-phosphate N-acetyltransferase (EC 2.3. 1.157) and UDP-N-acetylglucosamine diphosphorylase (EC 2.7. 7.23) perform the last two steps in the synthesis of UDP-N-acetylglucosamine, which is an essential precursor in both the peptidoglycan and the lipopolysaccharide metabolic pathway; bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase 889558..891009 Arthrobacter arilaitensis Re117 9793601 YP_003915989.1 CDS prs NC_014550.1 891082 892062 D catalyzes the formation of PRPP from ATP and ribose 5-phosphate. PRPP is then used in various biosynthetic pathways, as for example in the formation of purines, pyrimidines, histidine and tryptophan; ribose-phosphate diphosphokinase 891082..892062 Arthrobacter arilaitensis Re117 9793905 YP_003915990.1 CDS AARI_07980 NC_014550.1 892820 893566 D hypothetical protein 892820..893566 Arthrobacter arilaitensis Re117 9794234 YP_003915991.1 CDS AARI_07990 NC_014550.1 894921 895337 R hypothetical protein complement(894921..895337) Arthrobacter arilaitensis Re117 9793407 YP_003915992.1 CDS AARI_34640 NC_014550.1 895598 896905 D transposase of ISAar19, ISL3 family 895598..896905 Arthrobacter arilaitensis Re117 9797038 YP_003915993.1 CDS AARI_08000 NC_014550.1 897229 900018 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.575 between position 36 and 37. 7 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(897229..900018) Arthrobacter arilaitensis Re117 9793408 YP_003915994.1 CDS AARI_08010 NC_014550.1 900015 900635 R TCDB: ATP-binding cassette (ABC) superfamily, lipoprotein translocase (LPT) family (TC 3.A.1.125.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), o228 family (members of this family might be involved in a more general lipoprotein releasing mechanism common to all prokaryotes); ABC transporter ATP-binding subunit complement(900015..900635) Arthrobacter arilaitensis Re117 9797039 YP_003915995.1 CDS AARI_08020 NC_014550.1 901049 901534 R hypothetical protein complement(901049..901534) Arthrobacter arilaitensis Re117 9797040 YP_003915996.1 CDS AARI_34650 NC_014550.1 902168 902446 D transposase of ISAar3, IS3 family, IS407 group, orfA 902168..902446 Arthrobacter arilaitensis Re117 9797042 YP_003915997.1 CDS AARI_34660 NC_014550.1 902476 903315 D transposase of ISAar3, IS3 family, IS407 group, orfB 902476..903315 Arthrobacter arilaitensis Re117 9793409 YP_003915998.1 CDS AARI_08040 NC_014550.1 903909 904241 R hypothetical protein complement(903909..904241) Arthrobacter arilaitensis Re117 9793410 YP_003915999.1 CDS istB NC_014550.1 904238 904969 R helper of transposition of ISAar7, IS21 family, istB complement(904238..904969) Arthrobacter arilaitensis Re117 9797043 YP_003916000.1 CDS istA NC_014550.1 904966 906429 R transposase of ISAar7, IS21 family, istA complement(904966..906429) Arthrobacter arilaitensis Re117 9794019 YP_003916001.1 CDS AARI_08060 NC_014550.1 907397 908152 D signal peptide predicted by SignalP 3.0 HMM (probability: 1) with cleavage site probability 0.973 between position 26 and 27; hypothetical protein 907397..908152 Arthrobacter arilaitensis Re117 9797044 YP_003916002.1 CDS AARI_08070 NC_014550.1 908235 909416 D signal peptide predicted by SignalP 3.0 HMM (probability: 1) with cleavage site probability 0.751 between position 32 and 33; hypothetical protein 908235..909416 Arthrobacter arilaitensis Re117 9797045 YP_003916003.1 CDS AARI_34690 NC_014550.1 909820 911127 R transposase of ISAar20, ISL3 family complement(909820..911127) Arthrobacter arilaitensis Re117 9797046 YP_003916004.1 CDS AARI_34700 NC_014550.1 912376 913653 R transposase of ISAar13, ISL3 family complement(912376..913653) Arthrobacter arilaitensis Re117 9793411 YP_003916005.1 CDS AARI_08080 NC_014550.1 913958 914374 R hypothetical protein complement(913958..914374) Arthrobacter arilaitensis Re117 9793412 YP_003916006.1 CDS AARI_08090 NC_014550.1 914521 915093 R match to PF00239. Possibly involved in site- specific recombination of DNA; resolvase complement(914521..915093) Arthrobacter arilaitensis Re117 9797047 YP_003916007.1 CDS AARI_08100 NC_014550.1 915253 915783 D hypothetical protein 915253..915783 Arthrobacter arilaitensis Re117 9797048 YP_003916008.1 CDS rplY NC_014550.1 915999 916283 D part of the 50S ribosomal subunit. Contacts the 5S rRNA; 50S ribosomal protein L25 915999..916283 Arthrobacter arilaitensis Re117 9797049 YP_003916009.1 CDS pth NC_014550.1 916314 916895 D cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through abortion of translation and is essential for cell viability; peptidyl-tRNA hydrolase 916314..916895 Arthrobacter arilaitensis Re117 9794332 YP_003916010.1 CDS sufS NC_014550.1 917153 918445 D cysteine desulfurase catalyses the following reaction: L-cysteine + [enzyme]-cysteine <=> L-alanine + [enzyme]-S-sulfanylcysteine. It is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) and functions by mobilizing sulfur; cysteine desulfurase 917153..918445 Arthrobacter arilaitensis Re117 9794240 YP_003916011.1 CDS sufU NC_014550.1 918446 918898 D identified by match to protein family TIGR01994. The SUF system is an iron-sulfur cluster assembly system that operates under iron starvation and oxidative stress. SufU may act as a scaffold on which the Fe-S cluster is built and from which it is transferred; SUF system FeS assembly protein 918446..918898 Arthrobacter arilaitensis Re117 9794416 YP_003916012.1 CDS nhaA NC_014550.1 918977 920260 R NhaA Na+:H+antiporter (NhaA) family (TC 2.A.33.y.z). Na(+)/H(+) antiporter extrudes sodium in exchange for external protons. Active at alkaline pH. In E. coli, NhaA protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent; Na+/H+ antiporter NhaA complement(918977..920260) Arthrobacter arilaitensis Re117 9794417 YP_003916013.1 CDS AARI_08160 NC_014550.1 920498 920992 R hypothetical protein complement(920498..920992) Arthrobacter arilaitensis Re117 9794139 YP_003916014.1 CDS mfd NC_014550.1 921238 924852 D necessary for strand-specific repair. A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognized by TRCF which releases RNAP and the truncated transcript; the TCRF may replace RNAP at the lesion site and then recruit the uvrA/B/C repair system; transcription-repair-coupling factor 921238..924852 Arthrobacter arilaitensis Re117 9797050 YP_003916015.1 CDS AARI_08180 NC_014550.1 925175 925582 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(925175..925582) Arthrobacter arilaitensis Re117 9794080 YP_003916016.1 CDS AARI_08190 NC_014550.1 925774 926274 R hypothetical protein complement(925774..926274) Arthrobacter arilaitensis Re117 9797051 YP_003916017.1 CDS AARI_08200 NC_014550.1 926276 928174 R TCDB: P-type ATPase (P-ATPase) superfamily (TC 3.A. 3.y.z). Involved in export of cations; cation-transporting ATPase complement(926276..928174) Arthrobacter arilaitensis Re117 9797052 YP_003916018.1 CDS AARI_08210 NC_014550.1 928320 928487 R hypothetical protein complement(928320..928487) Arthrobacter arilaitensis Re117 9797053 YP_003916019.1 CDS AARI_08220 NC_014550.1 928702 928959 R hypothetical protein complement(928702..928959) Arthrobacter arilaitensis Re117 9797054 YP_003916020.1 CDS deoC NC_014550.1 928995 929681 R catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2- deoxyribose 5-phosphate; deoxyribose-phosphate aldolase complement(928995..929681) Arthrobacter arilaitensis Re117 9797055 YP_003916021.1 CDS AARI_08240 NC_014550.1 929741 931471 R this family is composed of four related enzymes, each of which catalyses a phosphoryl transfer on their sugar substrates: phosphoglucomutase (PGM), hosphoglucomutase/phosphomannomutase (PGM/PMM), phosphoglucosamine mutase (PNGM), and phosphoacetylglucosamine mutase (PAGM). PGM (EC:5.4.2.2) converts D-glucose 1-phosphate into D-glucose 6-phosphate, and participates in both the breakdown and synthesis of glucose. PGM/PMM (EC:5.4.2.2; EC:5.4.2.8) are primarily bacterial enzymes that use either glucose or mannose as substrate, participating in the biosynthesis of a variety of carbohydrates such as lipopolysaccharides and alginate. Both PNGM (EC:5.4.2.3) and PAGM (EC:5.4.2.10) are involved in the biosynthesis of UDP-N-acetylglucosamine; alpha-D-phosphohexomutase family protein complement(929741..931471) Arthrobacter arilaitensis Re117 9793803 YP_003916022.1 CDS deoD NC_014550.1 931525 932334 R catalyzes the cleavage of guanosine, deoxyguanosine, inosine, deoxyinosine, adenosine or deoxyadenosine to respective bases and sugar-1-phosphate molecules; purine-nucleoside phosphorylase complement(931525..932334) Arthrobacter arilaitensis Re117 9797056 YP_003916023.1 CDS lpdA NC_014550.1 932452 933861 D E3 component of pyruvate dehydrogenase and 2- oxoglutarate dehydrogenase complexes; dihydrolipoyl dehydrogenase 932452..933861 Arthrobacter arilaitensis Re117 9793804 YP_003916024.1 CDS AARI_34710 NC_014550.1 934010 935209 R transposase of ISAar5, IS256 family complement(934010..935209) Arthrobacter arilaitensis Re117 9794042 YP_003916025.1 CDS AARI_08270 NC_014550.1 935545 936933 D major facilitator superfamily (MFS), metabolite:H+ symporter (MHS) family (TC 2.A.1.6.z); MFS superfamily transporter 935545..936933 Arthrobacter arilaitensis Re117 9793413 YP_003916026.1 CDS AARI_08300 NC_014550.1 938047 938415 D hypothetical protein 938047..938415 Arthrobacter arilaitensis Re117 9797059 YP_003916027.1 CDS AARI_08310 NC_014550.1 938487 940271 R enzymes named acetyl-coenzyme A carboxylase (EC 6.4. 1.2), propionyl-coenzyme A carboxylase (EC 6.4.1.3) and acyl-coenzyme A carboxylase are constituted by several types of subunits. Alpha subunits contains the biotin carboxylase (BC, EC 6.3.4.14) and biotin carboxyl carrier protein (BCCP) domains, beta subunits contain the carboxyltransferase (CT) domain. An epsilon subunit is present in some microorganisms; acetyl-/propionyl-coenzyme A carboxylase subunit alpha complement(938487..940271) Arthrobacter arilaitensis Re117 9797060 YP_003916028.1 CDS AARI_34720 NC_014550.1 940490 941686 R transposase of ISAar2, IS110 family complement(940490..941686) Arthrobacter arilaitensis Re117 9797061 YP_003916029.1 CDS AARI_08320 NC_014550.1 942018 942377 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.973) with cleavage site probability 0.445 between position 32 and 33; hypothetical protein 942018..942377 Arthrobacter arilaitensis Re117 9793414 YP_003916030.1 CDS AARI_08330 NC_014550.1 942651 943139 R hypothetical protein complement(942651..943139) Arthrobacter arilaitensis Re117 9797062 YP_003916031.1 CDS AARI_08340 NC_014550.1 943195 943398 D hypothetical protein 943195..943398 Arthrobacter arilaitensis Re117 9797063 YP_003916032.1 CDS AARI_08350 NC_014550.1 943454 944095 R match to PF02545. Maf is a inhibitor of septum formation in eukaryotes, bacteria, and archaea; Maf-like protein complement(943454..944095) Arthrobacter arilaitensis Re117 9797064 YP_003916033.1 CDS AARI_08360 NC_014550.1 944092 947595 R Resistance-Nodulation-Cell Division (RND) superfamily (TC 2.A.6.y.z). C-terminal part of the protein: PS50156 domain (sterol-sensing domain). In bacteria, this domain is found in a number of drug resistance protein; drug exporter of the RND superfamily complement(944092..947595) Arthrobacter arilaitensis Re117 9797065 YP_003916034.1 CDS AARI_08370 NC_014550.1 947600 948271 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(947600..948271) Arthrobacter arilaitensis Re117 9797066 YP_003916035.1 CDS AARI_34730 NC_014550.1 948417 949772 R transposase of ISAar28, IS481 family complement(948417..949772) Arthrobacter arilaitensis Re117 9797067 YP_003916036.1 CDS AARI_34740 NC_014550.1 950999 952306 D transposase of ISAar19, ISL3 family 950999..952306 Arthrobacter arilaitensis Re117 9797068 YP_003916037.1 CDS AARI_08400 NC_014550.1 953085 953531 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.890) with cleavage site probability 0.644 between position 24 and 25. 3 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(953085..953531) Arthrobacter arilaitensis Re117 9797069 YP_003916038.1 CDS AARI_08410 NC_014550.1 953784 954440 D hypothetical protein 953784..954440 Arthrobacter arilaitensis Re117 9797070 YP_003916039.1 CDS AARI_08420 NC_014550.1 954559 954942 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 954559..954942 Arthrobacter arilaitensis Re117 9797071 YP_003916040.1 CDS AARI_08430 NC_014550.1 955060 955449 D identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein 955060..955449 Arthrobacter arilaitensis Re117 9797072 YP_003916041.1 CDS AARI_08440 NC_014550.1 955505 957172 R hypothetical protein complement(955505..957172) Arthrobacter arilaitensis Re117 9797073 YP_003916042.1 CDS AARI_08450 NC_014550.1 957522 963725 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 957522..963725 Arthrobacter arilaitensis Re117 9797074 YP_003916043.1 CDS AARI_08460 NC_014550.1 963778 964788 D identified by match to protein family PIRSF002849. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes; AAA-type ATPase enzymatic complex assembly chaperone 963778..964788 Arthrobacter arilaitensis Re117 9797075 YP_003916044.1 CDS AARI_08470 NC_014550.1 964788 966107 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 964788..966107 Arthrobacter arilaitensis Re117 9797076 YP_003916045.1 CDS AARI_08500 NC_014550.1 968460 969542 D match to PF06271. The molecular function of this region is unknown. However it be involved in transport of an as yet unknown set of ligands; RDD domain-containing protein 968460..969542 Arthrobacter arilaitensis Re117 9797079 YP_003916046.1 CDS AARI_08510 NC_014550.1 969539 970366 D match to PF00481: protein phosphatase 2C; protein phosphatase domain-containing protein 969539..970366 Arthrobacter arilaitensis Re117 9797080 YP_003916047.1 CDS AARI_08520 NC_014550.1 970363 972156 D match to PF00498. The forkhead-associated (FHA) domain is a phosphopeptide recognition domain found in many regulatory proteins; FHA domain-containing protein 970363..972156 Arthrobacter arilaitensis Re117 9797081 YP_003916048.1 CDS AARI_08530 NC_014550.1 972153 973712 D identified by match to protein domain PD000001. Match to PS00108 pattern. Protein kinases are a group of enzymes that possess a catalytic subunit which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. They play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiation; Ser/Thr protein kinase 972153..973712 Arthrobacter arilaitensis Re117 9795167 YP_003916049.1 CDS AARI_08540 NC_014550.1 973722 974423 D hypothetical protein 973722..974423 Arthrobacter arilaitensis Re117 9795168 YP_003916050.1 CDS AARI_08550 NC_014550.1 974509 974727 R identified by similarity to protein SP: P96886 (Mycobacterium tuberculosis). Enzymes named acetyl- coenzyme A carboxylase (EC 6.4.1.2), propionyl-coenzyme A carboxylase (EC 6.4.1.3) and acyl-coenzyme A carboxylase are constituted by several types of subunits. Alpha subunits contains the biotin carboxylase (BC, EC 6.3.4.14) and biotin carboxyl carrier protein (BCCP) domains, beta subunits contain the carboxyltransferase (CT) domain. An epsilon subunit is present in some microorganisms; acetyl-/propionyl-coenzyme A carboxylase subunit epsilon complement(974509..974727) Arthrobacter arilaitensis Re117 9795169 YP_003916051.1 CDS AARI_08560 NC_014550.1 974777 976387 R enzymes named acetyl-coenzyme A carboxylase (EC 6.4. 1.2), propionyl-coenzyme A carboxylase (EC 6.4.1.3) and acyl-coenzyme A carboxylase are constituted by several types of subunits. Alpha subunits contains the biotin carboxylase (BC, EC 6.3.4.14) and biotin carboxyl carrier protein (BCCP) domains, beta subunits contain the carboxyltransferase (CT) domain. An epsilon subunit is present in some microorganisms; acetyl-/propionyl-coenzyme A carboxylase subunit beta complement(974777..976387) Arthrobacter arilaitensis Re117 9795170 YP_003916052.1 CDS AARI_08570 NC_014550.1 976584 977441 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductase 976584..977441 Arthrobacter arilaitensis Re117 9795171 YP_003916053.1 CDS birA NC_014550.1 977498 978364 D acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon- dioxide ligase. This protein also activates biotin to form biotinyl-5-adenylate and transfers the biotin moiety to biotin-accepting proteins; biotin-(acetyl-CoA carboxylase) ligase 977498..978364 Arthrobacter arilaitensis Re117 9795172 YP_003916054.1 CDS AARI_08590 NC_014550.1 978451 978999 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 978451..978999 Arthrobacter arilaitensis Re117 9793720 YP_003916055.1 CDS cya NC_014550.1 978996 980207 D identified by similarity to protein SP:P27580 (Arthrobacter nicotianae). Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP; adenylate cyclase 978996..980207 Arthrobacter arilaitensis Re117 9795173 YP_003916056.1 CDS AARI_08610 NC_014550.1 980207 981163 D match to PF00481: protein phosphatase 2C; protein phosphatase domain-containing protein 980207..981163 Arthrobacter arilaitensis Re117 9793768 YP_003916057.1 CDS ligA NC_014550.1 981184 983487 D catalyzes the formation of phosphodiester linkages between 5 prime-phosphoryl and 3 prime-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; DNA ligase 981184..983487 Arthrobacter arilaitensis Re117 9795174 YP_003916058.1 CDS suhB NC_014550.1 983490 984290 D catalyzes the following reaction: myo-inositol phosphate + H(2)O <=> myo-inositol + phosphate. Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo- inositol bearing more than one phosphate group; inositol-phosphate phosphatase 983490..984290 Arthrobacter arilaitensis Re117 9794038 YP_003916059.1 CDS AARI_08640 NC_014550.1 984287 984898 R 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(984287..984898) Arthrobacter arilaitensis Re117 9794420 YP_003916060.1 CDS AARI_08650 NC_014550.1 985105 985461 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.959 between position 37 and 38; hypothetical protein 985105..985461 Arthrobacter arilaitensis Re117 9795175 YP_003916061.1 CDS AARI_08660 NC_014550.1 985576 986025 R hypothetical protein complement(985576..986025) Arthrobacter arilaitensis Re117 9795176 YP_003916062.1 CDS AARI_08690 NC_014550.1 986931 988061 R identified by match to PF00480: ROK family; transcriptional regulator complement(986931..988061) Arthrobacter arilaitensis Re117 9795179 YP_003916063.1 CDS AARI_08700 NC_014550.1 988273 988803 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 988273..988803 Arthrobacter arilaitensis Re117 9795180 YP_003916064.1 CDS AARI_08710 NC_014550.1 988895 990808 D match to PF00905. The large number of penicillin binding proteins, which are represented in this group of sequences, are responsible for the final stages of peptidoglycan biosynthesis for cell wall formation. The proteins synthesise cross-linked peptidoglycan from lipid intermediates, and contain a penicillin-sensitive transpeptidase carboxy-terminal domain; penicillin-binding protein 988895..990808 Arthrobacter arilaitensis Re117 9795181 YP_003916065.1 CDS AARI_08720 NC_014550.1 990826 991425 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(990826..991425) Arthrobacter arilaitensis Re117 9795182 YP_003916066.1 CDS AARI_08730 NC_014550.1 991511 992062 D hypothetical protein 991511..992062 Arthrobacter arilaitensis Re117 9795183 YP_003916067.1 CDS gatC NC_014550.1 992147 992443 D allows the formation of correctly charged Asn- tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; aspartyl/glutamyl-tRNA amidotransferase subunit C 992147..992443 Arthrobacter arilaitensis Re117 9795184 YP_003916068.1 CDS gatA NC_014550.1 992448 993986 D allows the formation of correctly charged Asn- tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; aspartyl/glutamyl-tRNA amidotransferase subunit A 992448..993986 Arthrobacter arilaitensis Re117 9793888 YP_003916069.1 CDS gatB NC_014550.1 993992 995500 D allows the formation of correctly charged Asn- tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; aspartyl/glutamyl-tRNA amidotransferase subunit B 993992..995500 Arthrobacter arilaitensis Re117 9793886 YP_003916070.1 CDS AARI_08770 NC_014550.1 995715 995840 R hypothetical protein complement(995715..995840) Arthrobacter arilaitensis Re117 9793887 YP_003916071.1 CDS AARI_08780 NC_014550.1 996223 996510 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(996223..996510) Arthrobacter arilaitensis Re117 9795185 YP_003916072.1 CDS AARI_34750 NC_014550.1 996588 997895 R transposase of ISAar19, ISL3 family complement(996588..997895) Arthrobacter arilaitensis Re117 9795186 YP_003916073.1 CDS AARI_08810 NC_014550.1 1000107 1001039 D identified by match to PF01636. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides. It also includes homoserine kinase; aminoglycoside phosphotransferase-like protein 1000107..1001039 Arthrobacter arilaitensis Re117 9795188 YP_003916074.1 CDS AARI_08820 NC_014550.1 1001461 1001805 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1001461..1001805) Arthrobacter arilaitensis Re117 9795189 YP_003916075.1 CDS AARI_08840 NC_014550.1 1002483 1003184 R identified by match to protein family TIGR01509: HAD-superfamily hydrolase, subfamily IA, variant 3; match to protein family PF00702: haloacid dehalogenase-like hydrolase; hydrolase complement(1002483..1003184) Arthrobacter arilaitensis Re117 9795191 YP_003916076.1 CDS AARI_08850 NC_014550.1 1003192 1003638 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(1003192..1003638) Arthrobacter arilaitensis Re117 9795192 YP_003916077.1 CDS AARI_08860 NC_014550.1 1003753 1004895 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 1003753..1004895 Arthrobacter arilaitensis Re117 9795193 YP_003916078.1 CDS dkgA NC_014550.1 1004940 1005770 D catalyzes the reduction of 2,5-diketogluconic acid to 2-keto-L-gulonic acid, a key intermediate in the production of ascorbic acid. Can also reduce ethyl 2- methylacetoacetate stereoselectively to ethyl (2R)-methyl- (3S)-hydroxybutanoate and can also accept some other beta- keto esters. Identified by similarity to protein SP:Q46857 (Escherichia coli); 2,5-didehydrogluconate reductase 1004940..1005770 Arthrobacter arilaitensis Re117 9795194 YP_003916079.1 CDS AARI_08880 NC_014550.1 1006160 1006462 R hypothetical protein complement(1006160..1006462) Arthrobacter arilaitensis Re117 9793817 YP_003916080.1 CDS AARI_08890 NC_014550.1 1006662 1007327 R hypothetical protein complement(1006662..1007327) Arthrobacter arilaitensis Re117 9795195 YP_003916081.1 CDS AARI_08900 NC_014550.1 1007386 1007787 R hypothetical protein complement(1007386..1007787) Arthrobacter arilaitensis Re117 9795196 YP_003916082.1 CDS AARI_08910 NC_014550.1 1008036 1008632 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1008036..1008632) Arthrobacter arilaitensis Re117 9795197 YP_003916083.1 CDS AARI_08920 NC_014550.1 1008779 1009531 D match to PS00383 pattern (tyrosine specific protein phosphatases active site); hypothetical protein 1008779..1009531 Arthrobacter arilaitensis Re117 9795198 YP_003916084.1 CDS AARI_08930 NC_014550.1 1009791 1010846 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(1009791..1010846) Arthrobacter arilaitensis Re117 9795199 YP_003916085.1 CDS AARI_08940 NC_014550.1 1011351 1011854 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1011351..1011854) Arthrobacter arilaitensis Re117 9795200 YP_003916086.1 CDS AARI_08950 NC_014550.1 1011915 1012457 R hypothetical protein complement(1011915..1012457) Arthrobacter arilaitensis Re117 9795201 YP_003916087.1 CDS AARI_08960 NC_014550.1 1012454 1012642 R hypothetical protein complement(1012454..1012642) Arthrobacter arilaitensis Re117 9795202 YP_003916088.1 CDS AARI_08970 NC_014550.1 1013023 1013586 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 1013023..1013586 Arthrobacter arilaitensis Re117 9795203 YP_003916089.1 CDS AARI_08980 NC_014550.1 1013760 1014467 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1013760..1014467) Arthrobacter arilaitensis Re117 9795204 YP_003916090.1 CDS AARI_08990 NC_014550.1 1014770 1015633 R hypothetical protein complement(1014770..1015633) Arthrobacter arilaitensis Re117 9795205 YP_003916091.1 CDS AARI_09010 NC_014550.1 1016535 1017287 R match to PF01636. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase; phosphotransferase complement(1016535..1017287) Arthrobacter arilaitensis Re117 9795207 YP_003916092.1 CDS AARI_09020 NC_014550.1 1018064 1018969 R identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator complement(1018064..1018969) Arthrobacter arilaitensis Re117 9795208 YP_003916093.1 CDS tdh NC_014550.1 1019105 1020157 D catalyses the conversion of L-threonine to L-2- amino-3-oxobutanoate; L-threonine 3-dehydrogenase 1019105..1020157 Arthrobacter arilaitensis Re117 9795209 YP_003916094.1 CDS kbl NC_014550.1 1020189 1021388 D catalyzes the addition of acetyl-CoA to glycine to form 2-amino-3-oxobutanoate: the second reaction step of the main metabolic degradation pathway for threonine; glycine C-acetyltransferase 1020189..1021388 Arthrobacter arilaitensis Re117 9794434 YP_003916095.1 CDS AARI_09050 NC_014550.1 1021477 1022493 D match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator 1021477..1022493 Arthrobacter arilaitensis Re117 9794024 YP_003916096.1 CDS AARI_09060 NC_014550.1 1022564 1023985 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, binding protein (BP), OSP-family (oligosaccharides or polyols); oligosaccharide/polyol ABC transporter substrate-binding protein 1022564..1023985 Arthrobacter arilaitensis Re117 9795210 YP_003916097.1 CDS AARI_09070 NC_014550.1 1024053 1025192 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, permease (IM), OSP- family (oligosaccharides or polyols); oligosaccharide/polyol ABC transporter inner membrane subunit 1024053..1025192 Arthrobacter arilaitensis Re117 9795211 YP_003916098.1 CDS AARI_09080 NC_014550.1 1025189 1026136 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, permease (IM), OSP- family (oligosaccharides or polyols); oligosaccharide/polyol ABC transporter inner membrane subunit 1025189..1026136 Arthrobacter arilaitensis Re117 9795212 YP_003916099.1 CDS hutI NC_014550.1 1026273 1027460 D catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5- dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L- glutamate; imidazolonepropionase 1026273..1027460 Arthrobacter arilaitensis Re117 9795213 YP_003916100.1 CDS AARI_09100 NC_014550.1 1027582 1028208 R identified by match to protein domain PF08241; SAM-dependent methyltransferase complement(1027582..1028208) Arthrobacter arilaitensis Re117 9793992 YP_003916101.1 CDS tpx NC_014550.1 1028307 1028804 D in Escherichia coli, Tpx is an antioxidant protein with a thiol peroxidase activity; thiol peroxidase 1028307..1028804 Arthrobacter arilaitensis Re117 9795214 YP_003916102.1 CDS AARI_09120 NC_014550.1 1028953 1029387 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.515 between position 29 and 30. Match to PS00383 pattern (aldehyde dehydrogenases glutamic acid active site); hypothetical protein complement(1028953..1029387) Arthrobacter arilaitensis Re117 9794459 YP_003916103.1 CDS AARI_09130 NC_014550.1 1029609 1030502 R identified by match to PF01636. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides. It also includes homoserine kinase; aminoglycoside phosphotransferase-like protein complement(1029609..1030502) Arthrobacter arilaitensis Re117 9795215 YP_003916104.1 CDS AARI_09140 NC_014550.1 1030499 1031344 R identified by match to PF01636. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides. It also includes homoserine kinase; aminoglycoside phosphotransferase-like protein complement(1030499..1031344) Arthrobacter arilaitensis Re117 9795216 YP_003916105.1 CDS AARI_09150 NC_014550.1 1031441 1032223 D identified by match to protein family PF02517: CAAX amino terminal protease family. Members of this family are probably proteases (after a prenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein, the AAX tripeptide is removed by one of the CAAX prenyl proteases). The family contains the Q03530 CAAX prenyl protease. 6 transmembrane helices predicted by TMHMM2.0; CAAX amino terminal protease 1031441..1032223 Arthrobacter arilaitensis Re117 9795217 YP_003916106.1 CDS AARI_09160 NC_014550.1 1032242 1032679 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 1032242..1032679 Arthrobacter arilaitensis Re117 9795218 YP_003916107.1 CDS AARI_09170 NC_014550.1 1032729 1033373 R hypothetical protein complement(1032729..1033373) Arthrobacter arilaitensis Re117 9795219 YP_003916108.1 CDS AARI_09180 NC_014550.1 1033757 1035100 D catalyses several reactions, including the formation of L-homocysteine from O-acetyl-L-homoserine and H2S, and the formation of L-methionine from O-acetyl-L- homoserine and methanethiol; O-acetylhomoserine aminocarboxypropyltransferase 1033757..1035100 Arthrobacter arilaitensis Re117 9795220 YP_003916109.1 CDS metX NC_014550.1 1035103 1036248 D first reaction in L-methionine biosynthesis; homoserine O-acetyltransferase 1035103..1036248 Arthrobacter arilaitensis Re117 9795221 YP_003916110.1 CDS AARI_09200 NC_014550.1 1036332 1037189 R identified by match to protein family PF00657; GDSL-like lipase/esterase complement(1036332..1037189) Arthrobacter arilaitensis Re117 9794079 YP_003916111.1 CDS AARI_09210 NC_014550.1 1037258 1037674 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(1037258..1037674) Arthrobacter arilaitensis Re117 9795222 YP_003916112.1 CDS AARI_09220 NC_014550.1 1037977 1039038 D 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1037977..1039038 Arthrobacter arilaitensis Re117 9795223 YP_003916113.1 CDS AARI_09230 NC_014550.1 1039035 1039397 D transcriptional regulator 1039035..1039397 Arthrobacter arilaitensis Re117 9795224 YP_003916114.1 CDS AARI_09240 NC_014550.1 1039471 1040121 D identified by match to protein family PF02230. This family consists of both phospholipases and carboxylesterases with broad substrate specificity; phospholipase/carboxylesterase 1039471..1040121 Arthrobacter arilaitensis Re117 9795225 YP_003916115.1 CDS AARI_09250 NC_014550.1 1040122 1040352 R match to protein domain PF01479. The S4 domain was detected in proteins such as the bacterial ribosomal protein S4, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. The S4 domain probably mediates binding to RNA; S4 domain-containing protein complement(1040122..1040352) Arthrobacter arilaitensis Re117 9795226 YP_003916116.1 CDS glyS NC_014550.1 1040533 1041918 D activates glycine and transfers it to tRNA(Gly) as the first step in protein biosynthesis; glycine--tRNA ligase 1040533..1041918 Arthrobacter arilaitensis Re117 9795227 YP_003916117.1 CDS AARI_09270 NC_014550.1 1041925 1042854 D hypothetical protein 1041925..1042854 Arthrobacter arilaitensis Re117 9793928 YP_003916118.1 CDS AARI_09280 NC_014550.1 1042935 1043936 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.937) with cleavage site probability 0.418 between position 40 and 41. 9 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 1042935..1043936 Arthrobacter arilaitensis Re117 9795228 YP_003916119.1 CDS AARI_09290 NC_014550.1 1044003 1045208 D Chromate Ion Transporter (CHR) family (TC 2.A.51.y. z). match to PF02417: this region is found in known and predicted chromate transporters, these proteins reduce chromate accumulation and are essential for chromate resistance; chromate transporter 1044003..1045208 Arthrobacter arilaitensis Re117 9795229 YP_003916120.1 CDS AARI_09300 NC_014550.1 1045205 1046848 R 12 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1045205..1046848) Arthrobacter arilaitensis Re117 9795230 YP_003916121.1 CDS AARI_09310 NC_014550.1 1046848 1047312 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.867 between position 34 and 35; hypothetical protein complement(1046848..1047312) Arthrobacter arilaitensis Re117 9795231 YP_003916122.1 CDS AARI_09320 NC_014550.1 1047416 1048600 D identified by match to protein family PF01207. Members of this family catalyse the reduction of the 5,6- double bond of a uridine residue on tRNA. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA; tRNA-dihydrouridine synthase 1047416..1048600 Arthrobacter arilaitensis Re117 9795232 YP_003916123.1 CDS dgt NC_014550.1 1048678 1049961 D dGTPase catalyses the formation of deoxyguanosine from dGTP. It is involved in purine metabolism; dGTPase 1048678..1049961 Arthrobacter arilaitensis Re117 9795233 YP_003916124.1 CDS dnaG NC_014550.1 1049971 1051854 D a nucleotidyltransferase which synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork. It can also prime the leading strand and has been implicated in cell division; DNA primase 1049971..1051854 Arthrobacter arilaitensis Re117 9793810 YP_003916125.1 CDS AARI_09350 NC_014550.1 1052110 1052937 R 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1052110..1052937) Arthrobacter arilaitensis Re117 9793602 YP_003916126.1 CDS AARI_09360 NC_014550.1 1053167 1053976 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1053167..1053976 Arthrobacter arilaitensis Re117 9795234 YP_003916127.1 CDS AARI_09370 NC_014550.1 1054193 1054351 R hypothetical protein complement(1054193..1054351) Arthrobacter arilaitensis Re117 9795235 YP_003916128.1 CDS AARI_09380 NC_014550.1 1054428 1055948 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase 1054428..1055948 Arthrobacter arilaitensis Re117 9795236 YP_003916129.1 CDS AARI_09390 NC_014550.1 1055945 1057504 D 11 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1055945..1057504 Arthrobacter arilaitensis Re117 9795237 YP_003916130.1 CDS AARI_09420 NC_014550.1 1058833 1059207 R hypothetical protein complement(1058833..1059207) Arthrobacter arilaitensis Re117 9795240 YP_003916131.1 CDS AARI_09430 NC_014550.1 1059344 1060000 D hypothetical protein 1059344..1060000 Arthrobacter arilaitensis Re117 9795241 YP_003916132.1 CDS ribH NC_014550.1 1060096 1060533 R catalyzes the condensation of 5-amino-6-(1-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4- dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8- lumazine; riboflavin synthase subunit beta complement(1060096..1060533) Arthrobacter arilaitensis Re117 9795242 YP_003916133.1 CDS AARI_09450 NC_014550.1 1060644 1061648 R identified by match to PF00296. Bacterial luciferase is a flavin monooxygenase that catalyses the oxidation of long-chain aldehydes and releases energy in the form of visible light, and which uses flavin as a substrate rather than a cofactor. There are structural similarities between bacterial luciferase and nonfluorescent flavoproteins (LuxF, FP390), alkanesulfonate monooxygenase (SsuD), and coenzyme F420- dependent terahydromethanopterin reductase, which make up clearly related families with somewhat different folds; luciferase-like monooxygenase complement(1060644..1061648) Arthrobacter arilaitensis Re117 9794299 YP_003916134.1 CDS AARI_09460 NC_014550.1 1061723 1062007 R match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein complement(1061723..1062007) Arthrobacter arilaitensis Re117 9795243 YP_003916135.1 CDS map NC_014550.1 1062054 1062836 D responsible for the removal of the amino-terminal (initiator) methionine from nascent eukaryotic cytosolic and cytoplasmic prokaryotic proteins if the penultimate amino acid is small and uncharged; methionyl aminopeptidase 1062054..1062836 Arthrobacter arilaitensis Re117 9795244 YP_003916136.1 CDS bioD NC_014550.1 1062833 1063561 R catalyses the following reaction: ATP + 7,8- diaminononanoate + CO(2) <=> ADP + phosphate + dethiobiotin; dethiobiotin synthase complement(1062833..1063561) Arthrobacter arilaitensis Re117 9794058 YP_003916137.1 CDS AARI_09490 NC_014550.1 1063558 1064736 R cytochrome P450 complement(1063558..1064736) Arthrobacter arilaitensis Re117 9793718 YP_003916138.1 CDS bioF NC_014550.1 1064736 1065908 R catalyzes an intermediate step in the biosynthesis of biotin, the addition of 6-carboxy-hexanoyl-CoA (pimeloyl-coA) to alanine to form 8-amino-7-oxononanoate: 6-carboxyhexanoyl-CoA + L-alanine <=> 8-amino-7- oxononanoate + CoA + CO(2); 8-amino-7-oxononanoate synthase complement(1064736..1065908) Arthrobacter arilaitensis Re117 9795245 YP_003916139.1 CDS bioA NC_014550.1 1065901 1067265 R catalyzes an intermediate step in the biosynthesis of biotin, the transamination of 7-keto-8-aminopelargonic acid (7-KAP) to form 7,8- diaminopelargonic acid (DAPA): S- adenosyl-L-methionine + 8-amino-7-oxononanoate <=> S- adenosyl-4-methylthio-2-oxobutanoate + 7,8- diaminononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase complement(1065901..1067265) Arthrobacter arilaitensis Re117 9793719 YP_003916140.1 CDS bioB NC_014550.1 1067262 1068494 R catalyses the following reaction: dethiobiotin + sulfur + 2 S-adenosyl-L-methionine <=> biotin + 2 L- methionine + 2 5-deoxyadenosine; biotin synthase complement(1067262..1068494) Arthrobacter arilaitensis Re117 9793716 YP_003916141.1 CDS AARI_09530 NC_014550.1 1068645 1069217 R match to PF03807: NADP oxidoreductase coenzyme F420- dependent; hypothetical protein complement(1068645..1069217) Arthrobacter arilaitensis Re117 9793717 YP_003916142.1 CDS AARI_09540 NC_014550.1 1069468 1070097 D hypothetical protein 1069468..1070097 Arthrobacter arilaitensis Re117 9795246 YP_003916143.1 CDS AARI_09550 NC_014550.1 1070165 1072513 R may be involved in aerobactin-like siderophore biosynthesis; siderophore biosynthesis protein complement(1070165..1072513) Arthrobacter arilaitensis Re117 9795247 YP_003916144.1 CDS AARI_09560 NC_014550.1 1072527 1073873 R L-lysine 6-monooxygenase (NADPH) catalyzes the conversion of lysine to its N6-hydroxy derivative, the initial event in the biosynthesis of aerobactin, a siderophore which functions as a virulence determinant in many septicemic organisms; L-lysine 6-monooxygenase (NADPH) complement(1072527..1073873) Arthrobacter arilaitensis Re117 9795248 YP_003916145.1 CDS AARI_09570 NC_014550.1 1073870 1075390 R identified by match to protein family PF00282; pyridoxal-dependent amino acid decarboxylase complement(1073870..1075390) Arthrobacter arilaitensis Re117 9795249 YP_003916146.1 CDS AARI_09580 NC_014550.1 1075719 1076972 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 1075719..1076972 Arthrobacter arilaitensis Re117 9795250 YP_003916147.1 CDS AARI_09590 NC_014550.1 1077015 1078088 D match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 1077015..1078088 Arthrobacter arilaitensis Re117 9795251 YP_003916148.1 CDS AARI_09600 NC_014550.1 1078575 1079420 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1078575..1079420 Arthrobacter arilaitensis Re117 9793603 YP_003916149.1 CDS AARI_09610 NC_014550.1 1079507 1080418 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.990) with cleavage site probability 0.909 between position 29 and 30. 7 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 1079507..1080418 Arthrobacter arilaitensis Re117 9795253 YP_003916150.1 CDS AARI_09620 NC_014550.1 1080477 1081658 D match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 1080477..1081658 Arthrobacter arilaitensis Re117 9795254 YP_003916151.1 CDS AARI_09630 NC_014550.1 1082277 1082774 R identified by match to protein family PF01551. Members of this family are zinc metallopeptidases with a range of specificities. Peptidase family M23 are also endopeptidases. Signal peptide predicted by SignalP 3.0 HMM (probability: 0.993) with cleavage site probability 0. 690 between position 27 and 28; peptidase M23 complement(1082277..1082774) Arthrobacter arilaitensis Re117 9793604 YP_003916152.1 CDS rpsB NC_014550.1 1083214 1084038 D 30S ribosomal protein S2 1083214..1084038 Arthrobacter arilaitensis Re117 9795256 YP_003916153.1 CDS tsf NC_014550.1 1084184 1085020 D associates with the elongation factor-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome; elongation factor Ts 1084184..1085020 Arthrobacter arilaitensis Re117 9794349 YP_003916154.1 CDS pyrH NC_014550.1 1085224 1085946 D catalyses the reversible transfer of the gamma- phosphoryl group from an ATP donor to UMP, yielding UDP, which is the starting point for the synthesis of all other pyrimidine nucleotides; uridylate kinase 1085224..1085946 Arthrobacter arilaitensis Re117 9794482 YP_003916155.1 CDS frr NC_014550.1 1086024 1086581 D responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; ribosome-recycling factor 1086024..1086581 Arthrobacter arilaitensis Re117 9794273 YP_003916156.1 CDS cdsA NC_014550.1 1086581 1087846 D phosphatidate cytidylyltransferase catalyzes the synthesis of CDP-diacylglycerol from CTP and phosphatidate. It produces key intermediates in phospholipid biosynthesis; phosphatidate cytidylyltransferase 1086581..1087846 Arthrobacter arilaitensis Re117 9793862 YP_003916157.1 CDS AARI_09690 NC_014550.1 1087970 1088542 D hypothetical protein 1087970..1088542 Arthrobacter arilaitensis Re117 9793733 YP_003916158.1 CDS AARI_09700 NC_014550.1 1088613 1089821 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(1088613..1089821) Arthrobacter arilaitensis Re117 9795257 YP_003916159.1 CDS AARI_09710 NC_014550.1 1089822 1090493 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(1089822..1090493) Arthrobacter arilaitensis Re117 9795258 YP_003916160.1 CDS AARI_09720 NC_014550.1 1090603 1092078 R Solute:Sodium Symporter (SSS) family (2.A.21.y.z). Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, organo cations such as choline, nucleosides, inositols, vitamins, urea or anions, depending on the system; Na+/solute symporter complement(1090603..1092078) Arthrobacter arilaitensis Re117 9795259 YP_003916161.1 CDS AARI_09730 NC_014550.1 1092071 1092478 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1092071..1092478) Arthrobacter arilaitensis Re117 9795260 YP_003916162.1 CDS AARI_09740 NC_014550.1 1092494 1093210 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(1092494..1093210) Arthrobacter arilaitensis Re117 9795261 YP_003916163.1 CDS AARI_09750 NC_014550.1 1093240 1094421 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 1 transmembrane helice predicted by TMHMM2.0; signal transduction histidine kinase complement(1093240..1094421) Arthrobacter arilaitensis Re117 9795262 YP_003916164.1 CDS AARI_09760 NC_014550.1 1094617 1094961 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1094617..1094961 Arthrobacter arilaitensis Re117 9795263 YP_003916165.1 CDS AARI_09770 NC_014550.1 1094962 1096587 D Solute:Sodium Symporter (SSS) family (2.A.21.y.z). Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, organo cations such as choline, nucleosides, inositols, vitamins, urea or anions, depending on the system; Na+/solute symporter 1094962..1096587 Arthrobacter arilaitensis Re117 9795264 YP_003916166.1 CDS AARI_09780 NC_014550.1 1096672 1097145 R identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator complement(1096672..1097145) Arthrobacter arilaitensis Re117 9795265 YP_003916167.1 CDS AARI_09790 NC_014550.1 1097296 1098411 D the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3); pyruvate dehydrogenase E1 component subunit alpha 1097296..1098411 Arthrobacter arilaitensis Re117 9795266 YP_003916168.1 CDS AARI_09800 NC_014550.1 1098414 1099415 D the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3); pyruvate dehydrogenase E1 component subunit beta 1098414..1099415 Arthrobacter arilaitensis Re117 9795267 YP_003916169.1 CDS AARI_09810 NC_014550.1 1099415 1100764 D the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3); dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex 1099415..1100764 Arthrobacter arilaitensis Re117 9795268 YP_003916170.1 CDS AARI_09820 NC_014550.1 1100961 1102592 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein 1100961..1102592 Arthrobacter arilaitensis Re117 9795269 YP_003916171.1 CDS AARI_09830 NC_014550.1 1102785 1103711 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 1102785..1103711 Arthrobacter arilaitensis Re117 9795270 YP_003916172.1 CDS AARI_09840 NC_014550.1 1103704 1104726 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 1103704..1104726 Arthrobacter arilaitensis Re117 9795271 YP_003916173.1 CDS AARI_09850 NC_014550.1 1104730 1106373 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, fused ATP-binding protein (ABC2), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit 1104730..1106373 Arthrobacter arilaitensis Re117 9795272 YP_003916174.1 CDS trt NC_014550.1 1106978 1108315 D identified by similarity to protein SP:Q6DKY2 (Bacillus stearothermophilus). Heat-stable reverse transcriptase. Possible group II intron associated protein; reverse transcriptase/maturase 1106978..1108315 Arthrobacter arilaitensis Re117 9795273 YP_003916175.1 CDS AARI_09870 NC_014550.1 1108770 1110572 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein 1108770..1110572 Arthrobacter arilaitensis Re117 9794475 YP_003916176.1 CDS AARI_09880 NC_014550.1 1110715 1112232 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 1110715..1112232 Arthrobacter arilaitensis Re117 9795274 YP_003916177.1 CDS AARI_09890 NC_014550.1 1112284 1113354 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 1112284..1113354 Arthrobacter arilaitensis Re117 9795275 YP_003916178.1 CDS AARI_09900 NC_014550.1 1113351 1115048 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, fused ATP-binding protein (ABC2), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit 1113351..1115048 Arthrobacter arilaitensis Re117 9795276 YP_003916179.1 CDS AARI_09910 NC_014550.1 1115181 1115672 D match to protein domain PF01814: Hemerythrin HHE cation binding domain. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor, protein P80255 binds cadmium so as to protect the organism from toxicity; cation binding domain-containing protein 1115181..1115672 Arthrobacter arilaitensis Re117 9795277 YP_003916180.1 CDS AARI_09920 NC_014550.1 1115703 1115897 D hypothetical protein 1115703..1115897 Arthrobacter arilaitensis Re117 9795278 YP_003916181.1 CDS AARI_09930 NC_014550.1 1115967 1116428 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1115967..1116428) Arthrobacter arilaitensis Re117 9795279 YP_003916182.1 CDS AARI_09940 NC_014550.1 1116498 1117118 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(1116498..1117118) Arthrobacter arilaitensis Re117 9795280 YP_003916183.1 CDS AARI_09950 NC_014550.1 1117358 1118512 D possibly involved in the metabolism of lipids. Match to protein domains PF08028, PF02771 and PF02770. Acyl-CoA dehydrogenases catalyze the alpha,beta- dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase 1117358..1118512 Arthrobacter arilaitensis Re117 9795281 YP_003916184.1 CDS dxr NC_014550.1 1118594 1119817 D catalyses the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH. Forms part of a non-mevalonate pathway for terpenoid biosynthesis; 1-deoxy-D-xylulose-5-phosphate reductoisomerase 1118594..1119817 Arthrobacter arilaitensis Re117 9795282 YP_003916185.1 CDS AARI_09970 NC_014550.1 1119814 1121163 D match to protein family PF02163: Peptidase family M50. Match to PS00142 pattern: neutral zinc metallopeptidases, zinc-binding region signature. 4 transmembrane helices predicted by TMHMM2.0; zinc metallopeptidase 1119814..1121163 Arthrobacter arilaitensis Re117 9793831 YP_003916186.1 CDS AARI_09980 NC_014550.1 1121187 1121486 D identified by match to protein domain PF03795; YCII-related domain-containing protein 1121187..1121486 Arthrobacter arilaitensis Re117 9795283 YP_003916187.1 CDS AARI_09990 NC_014550.1 1121601 1122023 D match to protein domain PF00472. This domain is found in peptide chain release factors, and a number of smaller proteins of unknown function; peptidyl-tRNA hydrolase domain-containing protein 1121601..1122023 Arthrobacter arilaitensis Re117 9795284 YP_003916188.1 CDS AARI_10000 NC_014550.1 1122145 1122699 D identified by match to PF03358. FMN reductase reductase catalyses the following reaction: NAD(P)H + FMN = NAD(P)(+) + FMNH(2); FMN reductase 1122145..1122699 Arthrobacter arilaitensis Re117 9795285 YP_003916189.1 CDS ispG NC_014550.1 1122840 1124006 D part of the non-mevalonate pathway for terpenoid biosynthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1122840..1124006 Arthrobacter arilaitensis Re117 9795286 YP_003916190.1 CDS AARI_10020 NC_014550.1 1124044 1124856 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 1124044..1124856 Arthrobacter arilaitensis Re117 9794013 YP_003916191.1 CDS AARI_10030 NC_014550.1 1124959 1125651 D hypothetical protein 1124959..1125651 Arthrobacter arilaitensis Re117 9795287 YP_003916192.1 CDS AARI_10040 NC_014550.1 1125704 1126453 D hypothetical protein 1125704..1126453 Arthrobacter arilaitensis Re117 9795288 YP_003916193.1 CDS AARI_10050 NC_014550.1 1126789 1126905 D hypothetical protein 1126789..1126905 Arthrobacter arilaitensis Re117 9795289 YP_003916194.1 CDS AARI_10060 NC_014550.1 1126927 1127478 D hypothetical protein 1126927..1127478 Arthrobacter arilaitensis Re117 9795290 YP_003916195.1 CDS AARI_10070 NC_014550.1 1128780 1128872 D hypothetical protein 1128780..1128872 Arthrobacter arilaitensis Re117 9793419 YP_003916196.1 CDS AARI_10080 NC_014550.1 1128984 1130150 D match to protein domains PF01590 and PF00486; transcriptional regulator 1128984..1130150 Arthrobacter arilaitensis Re117 9795292 YP_003916197.1 CDS AARI_10090 NC_014550.1 1130270 1132060 D FAD-dependent pyridine nucleotide-disulphide oxidoreductase 1130270..1132060 Arthrobacter arilaitensis Re117 9795293 YP_003916198.1 CDS AARI_10100 NC_014550.1 1132354 1132470 R hypothetical protein complement(1132354..1132470) Arthrobacter arilaitensis Re117 9795294 YP_003916199.1 CDS proS NC_014550.1 1132879 1134666 D activates proline and transfers it to tRNA(Pro) as the first step in protein biosynthesis; proline--tRNA ligase 1132879..1134666 Arthrobacter arilaitensis Re117 9795295 YP_003916200.1 CDS AARI_10120 NC_014550.1 1134703 1135518 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1134703..1135518 Arthrobacter arilaitensis Re117 9794229 YP_003916201.1 CDS AARI_10130 NC_014550.1 1135519 1135950 R hypothetical protein complement(1135519..1135950) Arthrobacter arilaitensis Re117 9795296 YP_003916202.1 CDS AARI_34780 NC_014550.1 1136091 1137125 D transposase of ISAar31, IS630 family 1136091..1137125 Arthrobacter arilaitensis Re117 9795297 YP_003916203.1 CDS AARI_10140 NC_014550.1 1137567 1138640 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(1137567..1138640) Arthrobacter arilaitensis Re117 9793420 YP_003916204.1 CDS AARI_10150 NC_014550.1 1138816 1139382 D hypothetical protein 1138816..1139382 Arthrobacter arilaitensis Re117 9795298 YP_003916205.1 CDS nusA NC_014550.1 1139385 1140368 D participates in both the termination and antitermination of transcription. Interacts with RNA polymerase and binds RNA; transcription elongation protein NusA 1139385..1140368 Arthrobacter arilaitensis Re117 9795299 YP_003916206.1 CDS AARI_10170 NC_014550.1 1140509 1140829 D hypothetical protein 1140509..1140829 Arthrobacter arilaitensis Re117 9794153 YP_003916207.1 CDS infB NC_014550.1 1141006 1143948 D one of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1141006..1143948 Arthrobacter arilaitensis Re117 9795300 YP_003916208.1 CDS rbfA NC_014550.1 1144050 1144484 D associates with free 30S ribosomal subunits. Essential for efficient processing of 16S rRNA; ribosome-binding factor A 1144050..1144484 Arthrobacter arilaitensis Re117 9794009 YP_003916209.1 CDS AARI_10200 NC_014550.1 1144674 1145141 D hypothetical protein 1144674..1145141 Arthrobacter arilaitensis Re117 9794283 YP_003916210.1 CDS AARI_10210 NC_014550.1 1145665 1146120 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(1145665..1146120) Arthrobacter arilaitensis Re117 9795301 YP_003916211.1 CDS AARI_10230 NC_014550.1 1146696 1148180 R match to protein domain PF00174, which corresponds to the molybdopterin binding domain of oxidoreductases that require a molybdopterin cofactor; molybdopterin oxidoreductase complement(1146696..1148180) Arthrobacter arilaitensis Re117 9795303 YP_003916212.1 CDS AARI_10240 NC_014550.1 1148379 1149200 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(1148379..1149200) Arthrobacter arilaitensis Re117 9795304 YP_003916213.1 CDS AARI_10250 NC_014550.1 1149200 1149757 R match to protein family TIGR02937. Sigma-70 family; RNA polymerase sigma factor complement(1149200..1149757) Arthrobacter arilaitensis Re117 9795305 YP_003916214.1 CDS AARI_10260 NC_014550.1 1149951 1150613 R match to protein domain PF02469: Fasciclin domain. This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria (for example in the bacterial immunogenic protein MPT70); lipoprotein complement(1149951..1150613) Arthrobacter arilaitensis Re117 9795306 YP_003916215.1 CDS truB NC_014550.1 1150927 1151850 D responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; tRNA pseudouridylate synthase B 1150927..1151850 Arthrobacter arilaitensis Re117 9795307 YP_003916216.1 CDS AARI_10280 NC_014550.1 1151868 1152230 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1151868..1152230 Arthrobacter arilaitensis Re117 9794477 YP_003916217.1 CDS AARI_10290 NC_014550.1 1152241 1152708 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1152241..1152708 Arthrobacter arilaitensis Re117 9795308 YP_003916218.1 CDS ribF NC_014550.1 1152772 1153725 D EC 2.7.1.26 catalyses the following reaction : ATP + riboflavin = ADP + FMN. EC 2.7.7.2 catalyses the following reaction : ATP + FMN = diphosphate + FAD; bifunctionnal riboflavin kinase/FAD synthetase 1152772..1153725 Arthrobacter arilaitensis Re117 9795309 YP_003916219.1 CDS AARI_10310 NC_014550.1 1153730 1154515 D identified by match to protein domain PF08241; SAM-dependent methyltransferase 1153730..1154515 Arthrobacter arilaitensis Re117 9794298 YP_003916220.1 CDS rpsO NC_014550.1 1154623 1154892 D one of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA; 30S ribosomal protein S15 1154623..1154892 Arthrobacter arilaitensis Re117 9795310 YP_003916221.1 CDS AARI_10330 NC_014550.1 1155283 1155414 D hypothetical protein 1155283..1155414 Arthrobacter arilaitensis Re117 9794362 YP_003916222.1 CDS AARI_10340 NC_014550.1 1155488 1156045 D hypothetical protein 1155488..1156045 Arthrobacter arilaitensis Re117 9795311 YP_003916223.1 CDS AARI_10350 NC_014550.1 1156042 1156650 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1156042..1156650 Arthrobacter arilaitensis Re117 9795312 YP_003916224.1 CDS AARI_10360 NC_014550.1 1156849 1157595 R match to PF01965: DJ-1/PfpI family. The family includes the protease PfpI Q51732. This domain is also found in transcriptional regulators such as Q9RJG8; DJ-1/PfpI family protein complement(1156849..1157595) Arthrobacter arilaitensis Re117 9795313 YP_003916225.1 CDS AARI_10400 NC_014550.1 1159258 1160355 D match to protein domain PF00266: aminotransferase class-V. This domain is found in aminotransferases, and other enzymes, including cysteine desulphurase; aminotransferase 1159258..1160355 Arthrobacter arilaitensis Re117 9795317 YP_003916226.1 CDS AARI_10410 NC_014550.1 1160448 1161464 R hypothetical protein complement(1160448..1161464) Arthrobacter arilaitensis Re117 9795318 YP_003916227.1 CDS AARI_10420 NC_014550.1 1161645 1162043 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1161645..1162043 Arthrobacter arilaitensis Re117 9795319 YP_003916228.1 CDS AARI_10430 NC_014550.1 1162113 1162514 R identified by match to PF00582: universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general stress endurance activity; universal stress family domain-containing protein complement(1162113..1162514) Arthrobacter arilaitensis Re117 9795320 YP_003916229.1 CDS tctA NC_014550.1 1162511 1164124 R Tripartite Tricarboxylate Transporter (TTT) Family, tricarboxylate transporter (TC 2.A.80.1.1). Identified by similarity to protein SP:Q6M234 (Corynebacterium glutamicum). Component of the TctCBA citrate uptake system; citrate transport protein TctA complement(1162511..1164124) Arthrobacter arilaitensis Re117 9795321 YP_003916230.1 CDS tctB NC_014550.1 1164146 1164649 R possible TctB component of the TctCBA citrate uptake system (TC 2.A.1.1); citrate transport protein TctB complement(1164146..1164649) Arthrobacter arilaitensis Re117 9794428 YP_003916231.1 CDS tctC NC_014550.1 1164646 1165659 R Tripartite Tricarboxylate Transporter (TTT) Family, tricarboxylate transporter (TC 2.A.80.1.1). Identified by similarity to protein SP:Q8NLW1 (Corynebacterium glutamicum). Component of the TctCBA citrate uptake system; citrate transport protein TctC complement(1164646..1165659) Arthrobacter arilaitensis Re117 9794429 YP_003916232.1 CDS AARI_10470 NC_014550.1 1165889 1167499 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase 1165889..1167499 Arthrobacter arilaitensis Re117 9794430 YP_003916233.1 CDS AARI_10480 NC_014550.1 1167510 1168184 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 1167510..1168184 Arthrobacter arilaitensis Re117 9795322 YP_003916234.1 CDS AARI_10490 NC_014550.1 1168269 1169663 R identified by match to protein family PF00743. Flavin-containing monooxygenase is a broad spectrum monooxygenase that accepts substrates as diverse as hydrazines, phosphines, boron-containing compounds, sulfides, selenides, iodide, as well as primary, secondary and tertiary amines. Generally converts nucleophilic heteroatom-containing chemicals and drugs into harmless, readily excreted metabolites; flavin-containing monooxygenase complement(1168269..1169663) Arthrobacter arilaitensis Re117 9795323 YP_003916235.1 CDS AARI_10500 NC_014550.1 1170180 1171040 R catalyzes the decarboxylation of prephenate into phenylpyruvate. Involved in phenylalanine biosynthesis; prephenate dehydratase complement(1170180..1171040) Arthrobacter arilaitensis Re117 9795324 YP_003916236.1 CDS AARI_10510 NC_014550.1 1171231 1171974 D identified by match to PF09339: IclR helix-turn- helix domain and PF01614. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 1171231..1171974 Arthrobacter arilaitensis Re117 9795325 YP_003916237.1 CDS AARI_10520 NC_014550.1 1172041 1173015 D also named branched-chain alpha-keto acid dehydrogenase E1 component alpha chain. The branched-chain alpha-keto dehydrogenase complex catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2- oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2; EC 2.3. 1.168) and lipoamide dehydrogenase (E3; EC1.8.1.4). The E1 component is composed of alpha and beta chains; 2-oxoisovalerate dehydrogenase subunit alpha 1172041..1173015 Arthrobacter arilaitensis Re117 9795326 YP_003916238.1 CDS AARI_10530 NC_014550.1 1173033 1174058 D also named branched-chain alpha-keto acid dehydrogenase E1 component beta chain. The branched-chain alpha-keto dehydrogenase complex catalyzes the oxidative decarboxylation of 4-methyl-2-oxopentanoate, 3-methyl-2- oxopentanoate and 3-methyl-2-oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2; EC 2.3. 1.168) and lipoamide dehydrogenase (E3; EC1.8.1.4). The E1 component is composed of alpha and beta chains; 2-oxoisovalerate dehydrogenase subunit beta 1173033..1174058 Arthrobacter arilaitensis Re117 9795327 YP_003916239.1 CDS AARI_10540 NC_014550.1 1174055 1174288 D possible lipoamide acyltransferase or N-terminal section of lipoamide acyltransferase (lipoyl-binding site). The branched-chain alpha-keto dehydrogenase complex catalyzes the oxidative decarboxylation of 4-methyl-2- oxopentanoate, 3-methyl-2-oxopentanoate and 3-methyl-2- oxobutanoate (branched chain 2-oxo acids derived from the transamination of leucine, valine and isoleucine). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2; EC 2.3.1.168) and lipoamide dehydrogenase (E3; EC1.8.1.4). The E1 component is composed of alpha and beta chains; lipoamide acyltransferase 1174055..1174288 Arthrobacter arilaitensis Re117 9795328 YP_003916240.1 CDS AARI_10550 NC_014550.1 1174413 1175423 R possibly involved in the metabolism of lipids. Match to protein family PF01370: NAD dependent epimerase/dehydratase family. This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; NAD dependent epimerase/dehydratase family protein complement(1174413..1175423) Arthrobacter arilaitensis Re117 9795329 YP_003916241.1 CDS AARI_10560 NC_014550.1 1175420 1178008 R match to protein family PF00501. This family of enzymes includes luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely- related synthetases; fatty acid Co-A ligase complement(1175420..1178008) Arthrobacter arilaitensis Re117 9795330 YP_003916242.1 CDS fabH NC_014550.1 1178005 1179030 R catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; beta-ketoacyl-ACP synthase III complement(1178005..1179030) Arthrobacter arilaitensis Re117 9795331 YP_003916243.1 CDS AARI_10590 NC_014550.1 1181069 1181197 R hypothetical protein complement(1181069..1181197) Arthrobacter arilaitensis Re117 9795332 YP_003916244.1 CDS AARI_10600 NC_014550.1 1181595 1182569 D ADP-ribosylglycohydrolase 1181595..1182569 Arthrobacter arilaitensis Re117 9795333 YP_003916245.1 CDS AARI_10610 NC_014550.1 1182592 1182903 R hypothetical protein complement(1182592..1182903) Arthrobacter arilaitensis Re117 9795334 YP_003916246.1 CDS AARI_10620 NC_014550.1 1183248 1183841 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1183248..1183841 Arthrobacter arilaitensis Re117 9795335 YP_003916247.1 CDS AARI_10630 NC_014550.1 1183933 1184976 R catalyses the following reaction: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH; Zn-dependent alcohol dehydrogenase complement(1183933..1184976) Arthrobacter arilaitensis Re117 9795336 YP_003916248.1 CDS AARI_10640 NC_014550.1 1185279 1186529 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(1185279..1186529) Arthrobacter arilaitensis Re117 9795337 YP_003916249.1 CDS AARI_10650 NC_014550.1 1186629 1187342 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.351 between position 44 and 45; hypothetical protein complement(1186629..1187342) Arthrobacter arilaitensis Re117 9795338 YP_003916250.1 CDS pnp NC_014550.1 1188017 1190254 D bifunctional enzyme, with a phosphorolytic 3 to 5 exoribonuclease activity and a 3 -terminal oligonucleotide polymerase activity. It is involved in mRNA processing and degradation; polyribonucleotide nucleotidyltransferase 1188017..1190254 Arthrobacter arilaitensis Re117 9795339 YP_003916251.1 CDS AARI_10670 NC_014550.1 1190327 1191598 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1190327..1191598) Arthrobacter arilaitensis Re117 9794210 YP_003916252.1 CDS AARI_10710 NC_014550.1 1193448 1194008 R purine nucleoside phosphorylase complement(1193448..1194008) Arthrobacter arilaitensis Re117 9795343 YP_003916253.1 CDS luxS NC_014550.1 1194129 1194620 D takes part in the activated methyl cycle, by salvaging the homocysteine moiety from the cycle intermediate S-D-ribosyl-L-homocysteine. As a by-product of this reaction, 4,5-dihydroxy-2,3-pentanedione is formed, which is the precursor of the autoinducer AI-2, a signal molecule, which may be used by a variety of bacteria for communication among and between species; S-ribosylhomocysteine lyase 1194129..1194620 Arthrobacter arilaitensis Re117 9795344 YP_003916254.1 CDS AARI_10730 NC_014550.1 1194759 1195142 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.977) with cleavage site probability 0.233 between position 29 and 30; hypothetical protein 1194759..1195142 Arthrobacter arilaitensis Re117 9794048 YP_003916255.1 CDS AARI_10740 NC_014550.1 1195318 1196688 D identified by match to PF05193 and PF00675. These metallopeptidases belong to MEROPS peptidase family M16 (clan ME). They also include proteins, which are classified as non-peptidase homologues either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity; peptidase M16 1195318..1196688 Arthrobacter arilaitensis Re117 9795345 YP_003916256.1 CDS AARI_10750 NC_014550.1 1196759 1197493 R match to PF00561: alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; hydrolase complement(1196759..1197493) Arthrobacter arilaitensis Re117 9795346 YP_003916257.1 CDS AARI_10760 NC_014550.1 1197583 1197993 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.769 between position 35 and 36; hypothetical protein complement(1197583..1197993) Arthrobacter arilaitensis Re117 9795347 YP_003916258.1 CDS dapB NC_014550.1 1198189 1198947 D catalyzes the second step in the biosynthesis of diaminopimelic acid and lysine, the NAD or NADP-dependent reduction of 2,3-dihydrodipicolinate into 2,3,4,5- tetrahydrodipicolinate; dihydrodipicolinate reductase 1198189..1198947 Arthrobacter arilaitensis Re117 9795348 YP_003916259.1 CDS AARI_10780 NC_014550.1 1198944 1199399 D identified by match to PF07719. The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins. It mediates protein-protein interactions and the assembly of multiprotein complexes. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding; tetratrico peptide repeat-containing protein 1198944..1199399 Arthrobacter arilaitensis Re117 9793789 YP_003916260.1 CDS AARI_10790 NC_014550.1 1199454 1200695 R 10 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1199454..1200695) Arthrobacter arilaitensis Re117 9795349 YP_003916261.1 CDS dapA NC_014550.1 1200694 1201605 D catalyses the condensation of aspartate semialdehyde and pyruvate, the first reaction specific to the biosynthesis of lysine and of diaminopimelate; dihydrodipicolinate synthase 1200694..1201605 Arthrobacter arilaitensis Re117 9795350 YP_003916262.1 CDS AARI_10810 NC_014550.1 1201625 1203331 D identified by match to PF00753 (metallo-beta- lactamase superfamily) and PF07521 (RNA-metabolising metallo-beta-lactamase motif); RNA-metabolising metallo-beta-lactamase 1201625..1203331 Arthrobacter arilaitensis Re117 9793788 YP_003916263.1 CDS AARI_10820 NC_014550.1 1203412 1203642 R hypothetical protein complement(1203412..1203642) Arthrobacter arilaitensis Re117 9795351 YP_003916264.1 CDS AARI_10830 NC_014550.1 1203863 1204690 D TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OTCN-family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L-proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter ATP-binding subunit 1203863..1204690 Arthrobacter arilaitensis Re117 9795352 YP_003916265.1 CDS AARI_10840 NC_014550.1 1204699 1205373 D TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, permease (IM), OTCN- family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L- proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter inner membrane subunit 1204699..1205373 Arthrobacter arilaitensis Re117 9795353 YP_003916266.1 CDS AARI_10850 NC_014550.1 1205370 1206101 D TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, permease (IM), OTCN- family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L- proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter inner membrane subunit 1205370..1206101 Arthrobacter arilaitensis Re117 9795354 YP_003916267.1 CDS AARI_10860 NC_014550.1 1206098 1207000 D TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, binding protein (BP), OTCN-family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L-proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter substrate-binding protein 1206098..1207000 Arthrobacter arilaitensis Re117 9795355 YP_003916268.1 CDS AARI_10870 NC_014550.1 1207239 1208258 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein 1207239..1208258 Arthrobacter arilaitensis Re117 9795356 YP_003916269.1 CDS AARI_10880 NC_014550.1 1208366 1209163 D hypothetical protein 1208366..1209163 Arthrobacter arilaitensis Re117 9795357 YP_003916270.1 CDS AARI_10890 NC_014550.1 1209156 1209992 D hypothetical protein 1209156..1209992 Arthrobacter arilaitensis Re117 9795358 YP_003916271.1 CDS AARI_10900 NC_014550.1 1209996 1211291 D hypothetical protein 1209996..1211291 Arthrobacter arilaitensis Re117 9795359 YP_003916272.1 CDS AARI_10910 NC_014550.1 1211288 1212550 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 1211288..1212550 Arthrobacter arilaitensis Re117 9795360 YP_003916273.1 CDS AARI_10920 NC_014550.1 1212547 1213653 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit 1212547..1213653 Arthrobacter arilaitensis Re117 9795361 YP_003916274.1 CDS AARI_10930 NC_014550.1 1213684 1214469 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter ATP-binding subunit 1213684..1214469 Arthrobacter arilaitensis Re117 9795362 YP_003916275.1 CDS lpdA NC_014550.1 1214557 1215960 D E3 component of pyruvate dehydrogenase and 2- oxoglutarate dehydrogenase complexes; dihydrolipoyl dehydrogenase 1214557..1215960 Arthrobacter arilaitensis Re117 9795363 YP_003916276.1 CDS AARI_10950 NC_014550.1 1216015 1216500 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1216015..1216500 Arthrobacter arilaitensis Re117 9794043 YP_003916277.1 CDS ftsK NC_014550.1 1216860 1219841 D DNA motor protein, which is both required to move DNA out of the region of the septum during cell division and for the septum formation. Tracks DNA in an ATP- dependent manner by generating positive supercoils in front of it and negative supercoils behind it; DNA translocase FtsK 1216860..1219841 Arthrobacter arilaitensis Re117 9795364 YP_003916278.1 CDS pgsA NC_014550.1 1219847 1220449 D involved in phospholipid biosynthesis; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1219847..1220449 Arthrobacter arilaitensis Re117 9793866 YP_003916279.1 CDS AARI_10980 NC_014550.1 1220460 1220942 D match to protein family PF02464: competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon, and is thought to be specifically required at some stage in the process of transformation; CinA-like protein 1220460..1220942 Arthrobacter arilaitensis Re117 9794201 YP_003916280.1 CDS AARI_10990 NC_014550.1 1221232 1221552 D match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein 1221232..1221552 Arthrobacter arilaitensis Re117 9795365 YP_003916281.1 CDS AARI_11000 NC_014550.1 1221663 1221887 D hypothetical protein 1221663..1221887 Arthrobacter arilaitensis Re117 9795366 YP_003916282.1 CDS recA NC_014550.1 1222129 1223181 D RecA is a DNA-dependent ATPase and functions in DNA repair systems. RecA protein catalyses an ATP-dependent DNA strand-exchange reaction that is the central step in the repair of dsDNA breaks by homologous recombination; RecA bacterial DNA recombination protein 1222129..1223181 Arthrobacter arilaitensis Re117 9795367 YP_003916283.1 CDS recX NC_014550.1 1223181 1224068 D RecX is a bacterial regulatory protein. The gene encoding RecX is found downstream of recA, and is thought to interact with the RecA protein; regulatory protein RecX 1223181..1224068 Arthrobacter arilaitensis Re117 9794286 YP_003916284.1 CDS miaB NC_014550.1 1224546 1226075 D the MiaB enzyme is responsible for the modification of the isopentenylated adenine-37 base of most bacterial and eukaryotic tRNAs that read codons beginning with uracil. Adenine-37 is next to the anticodon on the 3 side in these tRNAs, and lack of modification at this site leads to an increased spontaneous mutation frequency; tRNA-i(6)A37 thiotransferase enzyme MiaB 1224546..1226075 Arthrobacter arilaitensis Re117 9794292 YP_003916285.1 CDS miaA NC_014550.1 1226080 1226982 D tRNA isopentenyltransferase 1226080..1226982 Arthrobacter arilaitensis Re117 9794082 YP_003916286.1 CDS dapF NC_014550.1 1227015 1227950 D catalyzes the isomerization of L,L- to D,L-meso- diaminopimelate in the biosynthetic pathway leading from aspartate to lysine; diaminopimelate epimerase 1227015..1227950 Arthrobacter arilaitensis Re117 9794081 YP_003916287.1 CDS AARI_11060 NC_014550.1 1228107 1228406 D hypothetical protein 1228107..1228406 Arthrobacter arilaitensis Re117 9793793 YP_003916288.1 CDS AARI_11070 NC_014550.1 1228417 1228716 D hypothetical protein 1228417..1228716 Arthrobacter arilaitensis Re117 9795368 YP_003916289.1 CDS AARI_34790 NC_014550.1 1229257 1230612 R transposase of ISAar28, IS481 family complement(1229257..1230612) Arthrobacter arilaitensis Re117 9795369 YP_003916290.1 CDS AARI_11080 NC_014550.1 1230848 1231909 D hypothetical protein 1230848..1231909 Arthrobacter arilaitensis Re117 9793421 YP_003916291.1 CDS AARI_11090 NC_014550.1 1231963 1232568 R match to protein domain PF05175. This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases; methyltransferase complement(1231963..1232568) Arthrobacter arilaitensis Re117 9795370 YP_003916292.1 CDS AARI_11100 NC_014550.1 1232894 1234555 D identified by match to protein family PF01926; GTPase 1232894..1234555 Arthrobacter arilaitensis Re117 9795371 YP_003916293.1 CDS AARI_11110 NC_014550.1 1234548 1236542 D possible DNA or RNA helicase; ATP-dependent helicase 1234548..1236542 Arthrobacter arilaitensis Re117 9795372 YP_003916294.1 CDS AARI_11120 NC_014550.1 1236681 1237736 D glycosyl hydrolase 1236681..1237736 Arthrobacter arilaitensis Re117 9795373 YP_003916295.1 CDS lexA NC_014550.1 1237793 1238512 R LexA represses around 20 genes of the cellular SOS response to DNA damage in Escherichia coli. In the presence of single-stranded DNA, the recA protein interacts with lexA causing an autocatalytic cleavage which disrupts the DNA- binding part of lexA, leading to derepression of the SOS regulon and eventually DNA repair; LexA repressor complement(1237793..1238512) Arthrobacter arilaitensis Re117 9795374 YP_003916296.1 CDS AARI_11140 NC_014550.1 1238771 1239124 D match to protein domain PF01476. This domain is about 40 residues long and is found in a variety of enzymes involved in bacterial cell wall degradation. It may have a general peptidoglycan binding function; LysM domain-containing protein 1238771..1239124 Arthrobacter arilaitensis Re117 9794036 YP_003916297.1 CDS hisC NC_014550.1 1239206 1240312 D catalyzes the the transfer of an amino group from 3- (imidazol-4-yl)-2-oxopropyl phosphate to glutamic acid to form histidinol phosphate and 2-oxoglutarate. Involved in histidine biosynthesis; histidinol-phosphate transaminase 1239206..1240312 Arthrobacter arilaitensis Re117 9795375 YP_003916298.1 CDS hisB NC_014550.1 1240335 1240955 D catalyzes the following reaction: D-erythro-1- (imidazol-4-yl)glycerol 3-phosphate <=> 3-(imidazol-4-yl)- 2-oxopropyl phosphate + H(2)O. Involved in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 1240335..1240955 Arthrobacter arilaitensis Re117 9793962 YP_003916299.1 CDS hisH NC_014550.1 1240956 1241591 D imidazole glycerol phosphate synthase converts N1- (5-phosphoribulosyl)-formimino-5-aminoimidazole-4- carboxamide ribonucleotide (PRFAR) to imidazole glycerol phosphate (ImGP) and 5-(5-aminoimidazole-4-carboxamide) ribonucleotide (AICAR). Involved in histidine biosynthesis; imidazole glycerol phosphate synthase, glutamine amidotransferase subunit 1240956..1241591 Arthrobacter arilaitensis Re117 9793961 YP_003916300.1 CDS AARI_11180 NC_014550.1 1241594 1241743 D hypothetical protein 1241594..1241743 Arthrobacter arilaitensis Re117 9793967 YP_003916301.1 CDS hisA NC_014550.1 1241771 1242508 D catalyses the following reaction: 1-(5- phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide <=> 5-((5-phospho-1-deoxyribulos-1- ylamino)methylideneamino)- 1-(5-phosphoribosyl)imidazole-4- carboxamide. Involved in histidine biosynthesis; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 1241771..1242508 Arthrobacter arilaitensis Re117 9795376 YP_003916302.1 CDS AARI_11200 NC_014550.1 1242732 1243613 D hypothetical protein 1242732..1243613 Arthrobacter arilaitensis Re117 9793960 YP_003916303.1 CDS AARI_11210 NC_014550.1 1243655 1244992 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 1243655..1244992 Arthrobacter arilaitensis Re117 9795377 YP_003916304.1 CDS AARI_11220 NC_014550.1 1244989 1245540 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1244989..1245540) Arthrobacter arilaitensis Re117 9795378 YP_003916305.1 CDS AARI_11230 NC_014550.1 1245638 1246003 R hypothetical protein complement(1245638..1246003) Arthrobacter arilaitensis Re117 9795379 YP_003916306.1 CDS infC NC_014550.1 1246334 1246984 D IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins; translation initiation factor IF-3 1246334..1246984 Arthrobacter arilaitensis Re117 9795380 YP_003916307.1 CDS rpmI NC_014550.1 1247151 1247345 D L35 is a basic protein of 60 to 70 amino-acid residues from the large (50S) subunit; 50S ribosomal protein L35 1247151..1247345 Arthrobacter arilaitensis Re117 9794010 YP_003916308.1 CDS rplT NC_014550.1 1247450 1248097 D binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit; 50S ribosomal protein L20 1247450..1248097 Arthrobacter arilaitensis Re117 9794340 YP_003916309.1 CDS AARI_11270 NC_014550.1 1248209 1249087 D identified by match to protein family PF00588: SpoU rRNA Methylase family. Possible role in rRNA modification; RNA methyltransferase 1248209..1249087 Arthrobacter arilaitensis Re117 9794327 YP_003916310.1 CDS AARI_11280 NC_014550.1 1249113 1249553 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 1249113..1249553 Arthrobacter arilaitensis Re117 9795381 YP_003916311.1 CDS AARI_11290 NC_014550.1 1249640 1250269 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.878) with cleavage site probability 0.809 between position 28 and 29. 1 transmembrane helice predicted by TMHMM2.0 after the signal peptide; hypothetical protein 1249640..1250269 Arthrobacter arilaitensis Re117 9795382 YP_003916312.1 CDS pheS NC_014550.1 1250412 1251491 D activates phenylalanine and transfers it to tRNA(Phe) as the first step in protein biosynthesis; phenylalanine--tRNA ligase subunit alpha 1250412..1251491 Arthrobacter arilaitensis Re117 9795383 YP_003916313.1 CDS pheT NC_014550.1 1251495 1254038 D activates phenylalanine and transfers it to tRNA(Phe) as the first step in protein biosynthesis; phenylalanine--tRNA ligase subunit beta 1251495..1254038 Arthrobacter arilaitensis Re117 9794204 YP_003916314.1 CDS AARI_11320 NC_014550.1 1254173 1254400 D hypothetical protein 1254173..1254400 Arthrobacter arilaitensis Re117 9794205 YP_003916315.1 CDS AARI_11330 NC_014550.1 1254397 1254882 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1254397..1254882) Arthrobacter arilaitensis Re117 9795384 YP_003916316.1 CDS AARI_11340 NC_014550.1 1254964 1255245 R hypothetical protein complement(1254964..1255245) Arthrobacter arilaitensis Re117 9795385 YP_003916317.1 CDS AARI_11350 NC_014550.1 1255361 1255834 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 1255361..1255834 Arthrobacter arilaitensis Re117 9795386 YP_003916318.1 CDS AARI_11360 NC_014550.1 1255895 1256416 R match to protein domain PF00156. This family includes a range of diverse phosphoribosyl transferase enzymes; phosphoribosyl transferase complement(1255895..1256416) Arthrobacter arilaitensis Re117 9795387 YP_003916319.1 CDS AARI_11370 NC_014550.1 1256711 1258225 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.971 between position 30 and 31. 1 transmembrane helice predicted by TMHMM2.0 after the signal peptide; hypothetical protein 1256711..1258225 Arthrobacter arilaitensis Re117 9795388 YP_003916320.1 CDS AARI_11380 NC_014550.1 1258267 1258905 D identified by match to PF01648: 4- phosphopantetheinyl transferase superfamily. Holo-[acyl- carrier-protein] synthase catalyses the following reaction: CoA-(4-phosphopantetheine) + apo-[acyl-carrier- protein] => adenosine 3,5-bisphosphate + holo-[acyl- carrier-protein]. All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post- translational modification of their constituent acyl- carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain; holo-ACP synthase 1258267..1258905 Arthrobacter arilaitensis Re117 9795389 YP_003916321.1 CDS AARI_11390 NC_014550.1 1258929 1259825 R identified by match to protein domain PF03976. This domain is about 230 amino acids in length and has polyphosphate kinase activity; polyphosphate kinase domain-containing protein complement(1258929..1259825) Arthrobacter arilaitensis Re117 9795390 YP_003916322.1 CDS AARI_11400 NC_014550.1 1259958 1261259 R identified by match to protein family PF01433. This group of metallopeptidases belong to the MEROPS peptidase family M1 (clan MA(E)). Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. Match to PS00142 pattern: neutral zinc metallopeptidases, zinc-binding region signature; aminopeptidase M1 complement(1259958..1261259) Arthrobacter arilaitensis Re117 9795391 YP_003916323.1 CDS AARI_11410 NC_014550.1 1261273 1265208 R match to protein domains TIGR02353 and TIGR01733. May be involved in enterobactin-like siderophore biosynthesis; non-ribosomal peptide synthetase component complement(1261273..1265208) Arthrobacter arilaitensis Re117 9795392 YP_003916324.1 CDS AARI_11420 NC_014550.1 1265373 1266293 R identified by match to protein family PF04909; amidohydrolase complement(1265373..1266293) Arthrobacter arilaitensis Re117 9795393 YP_003916325.1 CDS qor NC_014550.1 1266296 1267264 R NADPH:quinone reductase catalyzes the following reaction: NADPH + quinone <=> NADP(+) + semiquinone. Quinone or similar compounds may act as acceptor; NADPH:quinone reductase complement(1266296..1267264) Arthrobacter arilaitensis Re117 9795394 YP_003916326.1 CDS argC NC_014550.1 1267448 1268479 D catalyzes the third step in the biosynthesis of arginine from glutamate, the NADP-dependent reduction of N- acetyl-5-glutamyl phosphate into N-acetylglutamate 5- semialdehyde; N-acetyl-gamma-glutamyl-phosphate reductase 1267448..1268479 Arthrobacter arilaitensis Re117 9794279 YP_003916327.1 CDS argJ NC_014550.1 1268476 1269690 D glutamate N-acetyltransferase (EC 2.3.1.35) catalyses the production of L-ornithine and N-acetyl-L- glutamate from N(2)-acetyl-L-ornithine and L-glutamate. Amino-acid N-acetyltransferase (EC 2.3.1.1) catalyses the formation of N-acetyl-L-glutamate from acetyl-CoA and L- glutamate. Involved in arginine biosynthesis; bifunctional glutamate N-acetyltransferase/amino-acid N-acetyltransferase protein 1268476..1269690 Arthrobacter arilaitensis Re117 9793673 YP_003916328.1 CDS argB NC_014550.1 1269712 1270665 D catalyses the formation of N-acetyl-L-glutamate 5- phosphate from N-acetyl-L-glutamate. Involved in arginine biosynthesis; acetylglutamate kinase 1269712..1270665 Arthrobacter arilaitensis Re117 9793679 YP_003916329.1 CDS argD NC_014550.1 1270665 1271930 D catalyses the following reaction: N(2)-acetyl-L- ornithine + 2-oxoglutarate <=> N-acetyl-L-glutamate 5- semialdehyde + L-glutamate. Involved in arginine biosynthesis; acetylornithine transaminase 1270665..1271930 Arthrobacter arilaitensis Re117 9793672 YP_003916330.1 CDS argF NC_014550.1 1271981 1272940 D catalyzes the conversion of ornithine and carbamoyl phosphate to citrulline. It is involved in the biosynthesis of arginine and, in some bacteria, it is also involved in the degradation of arginine (the arginine deaminase pathway); ornithine carbamoyltransferase 1271981..1272940 Arthrobacter arilaitensis Re117 9793674 YP_003916331.1 CDS argR NC_014550.1 1272942 1273445 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1272942..1273445 Arthrobacter arilaitensis Re117 9793676 YP_003916332.1 CDS AARI_11500 NC_014550.1 1273542 1275440 D identified by match to PF01844; HNH endonuclease domain-containing protein 1273542..1275440 Arthrobacter arilaitensis Re117 9793680 YP_003916333.1 CDS AARI_11510 NC_014550.1 1275565 1276131 R match to protein domain PF01661. This domain is an ADP-ribose binding module. It is found in a number of otherwise unrelated proteins; macro domain-containing protein complement(1275565..1276131) Arthrobacter arilaitensis Re117 9795395 YP_003916334.1 CDS argH NC_014550.1 1276386 1277801 D catalyzes the formation of arginine and fumarate from argininosuccinate, the last step in the biosynthesis of arginine; argininosuccinate lyase 1276386..1277801 Arthrobacter arilaitensis Re117 9795396 YP_003916335.1 CDS AARI_11530 NC_014550.1 1277918 1278658 D hypothetical protein 1277918..1278658 Arthrobacter arilaitensis Re117 9793678 YP_003916336.1 CDS apt NC_014550.1 1278755 1279303 D catalyses the formation of AMP and diphosphate from adenine and 5-phospho-alpha-D-ribose 1-diphosphate. Involved in purine salvage; adenine phosphoribosyltransferase 1278755..1279303 Arthrobacter arilaitensis Re117 9795397 YP_003916337.1 CDS AARI_11550 NC_014550.1 1279544 1281823 D match to protein family PS51198: UvrD-like DNA helicase ATP-binding domain profile. UvrD-like DNA helicases belong to superfamily 1 (SF1); ATP-dependent DNA helicase 1279544..1281823 Arthrobacter arilaitensis Re117 9793668 YP_003916338.1 CDS tyrS NC_014550.1 1282025 1283350 D activates tyrosine and transfers it to tRNA(Tyr) as the first step in protein biosynthesis; tyrosine--tRNA ligase 1282025..1283350 Arthrobacter arilaitensis Re117 9795398 YP_003916339.1 CDS AARI_34800 NC_014550.1 1289641 1290840 D transposase of ISAar5, IS256 family 1289641..1290840 Arthrobacter arilaitensis Re117 9793607 YP_003916340.1 CDS AARI_11570 NC_014550.1 1291158 1293482 D hypothetical protein 1291158..1293482 Arthrobacter arilaitensis Re117 9793422 YP_003916341.1 CDS AARI_11580 NC_014550.1 1293531 1294538 D identified by match to PF00702. This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases; haloacid dehalogenase 1293531..1294538 Arthrobacter arilaitensis Re117 9795399 YP_003916342.1 CDS AARI_11590 NC_014550.1 1294541 1294714 D hypothetical protein 1294541..1294714 Arthrobacter arilaitensis Re117 9795400 YP_003916343.1 CDS AARI_11600 NC_014550.1 1294711 1295499 D identified by similarity to protein SP:Q50760 (Mycobacterium tuberculosis); haemolysin 1294711..1295499 Arthrobacter arilaitensis Re117 9795401 YP_003916344.1 CDS ppnK NC_014550.1 1295518 1296600 D catalyses the phosphorylation of NAD to NADP utilising ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus; NAD(+) kinase 1295518..1296600 Arthrobacter arilaitensis Re117 9795402 YP_003916345.1 CDS recN NC_014550.1 1296718 1298472 D RecN is thought to be involved in recombinational repair of damaged DNA; DNA repair protein RecN 1296718..1298472 Arthrobacter arilaitensis Re117 9794219 YP_003916346.1 CDS pyrG NC_014550.1 1298580 1300259 D catalyzes the ATP-dependent formation of CTP from UTP and glutamine; CTP synthase 1298580..1300259 Arthrobacter arilaitensis Re117 9794289 YP_003916347.1 CDS AARI_11640 NC_014550.1 1300374 1301018 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 1300374..1301018 Arthrobacter arilaitensis Re117 9794272 YP_003916348.1 CDS xerD NC_014550.1 1301015 1301938 D site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids; tyrosine recombinase subunit XerD 1301015..1301938 Arthrobacter arilaitensis Re117 9795403 YP_003916349.1 CDS AARI_11660 NC_014550.1 1301941 1302441 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 1301941..1302441 Arthrobacter arilaitensis Re117 9794508 YP_003916350.1 CDS AARI_11670 NC_014550.1 1302456 1302668 R match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein complement(1302456..1302668) Arthrobacter arilaitensis Re117 9795404 YP_003916351.1 CDS AARI_11680 NC_014550.1 1302668 1303171 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.981) with cleavage site probability 0.558 between position 27 and 28. 3 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(1302668..1303171) Arthrobacter arilaitensis Re117 9795405 YP_003916352.1 CDS prpC NC_014550.1 1303300 1304439 R 2-methylcitrate synthase catalyses the conversion of oxaloacetate and propanoyl-CoA into (2R,3S)-2- hydroxybutane-1,2,3-tricarboxylate and coenzyme A. The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA. Involved in the metabolism of propionate; 2-methylcitrate synthase complement(1303300..1304439) Arthrobacter arilaitensis Re117 9795406 YP_003916353.1 CDS prpB NC_014550.1 1304534 1305463 R catalyses the formation of pyruvate and succinate from (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate. Involved in the metabolism of propionate; methylisocitrate lyase complement(1304534..1305463) Arthrobacter arilaitensis Re117 9794231 YP_003916354.1 CDS prpD NC_014550.1 1305465 1306982 R involved in the metabolism of propionate; 2-methylcitrate dehydratase complement(1305465..1306982) Arthrobacter arilaitensis Re117 9794230 YP_003916355.1 CDS AARI_11720 NC_014550.1 1306979 1307632 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(1306979..1307632) Arthrobacter arilaitensis Re117 9794232 YP_003916356.1 CDS prpE NC_014550.1 1307820 1309736 D catalyzes the synthesis of propionyl-CoA from propionate and CoA; propionate--CoA ligase 1307820..1309736 Arthrobacter arilaitensis Re117 9795407 YP_003916357.1 CDS AARI_11740 NC_014550.1 1309762 1310511 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(1309762..1310511) Arthrobacter arilaitensis Re117 9794233 YP_003916358.1 CDS AARI_11750 NC_014550.1 1310527 1312164 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(1310527..1312164) Arthrobacter arilaitensis Re117 9795408 YP_003916359.1 CDS dctA NC_014550.1 1312340 1313638 D identified by similarity to protein SP:Q8NMH8 (Corynebacterium glutamicum). Dicarboxylate/Amino Acid:Cation (Na+ or H+) symporter (DAACS) family, C4- dicarboxylate transporter (substrates: fumarate, D- and L- malate, succinate, succinamide, orotate, iticonate, mesaconate) (TC 2.A.23.1.3); C4-dicarboxylate transporter 1312340..1313638 Arthrobacter arilaitensis Re117 9795409 YP_003916360.1 CDS AARI_11770 NC_014550.1 1313767 1314390 D identified by match to protein family PF00657; GDSL-like lipase/esterase 1313767..1314390 Arthrobacter arilaitensis Re117 9793796 YP_003916361.1 CDS AARI_11790 NC_014550.1 1314847 1315197 R identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein complement(1314847..1315197) Arthrobacter arilaitensis Re117 9795411 YP_003916362.1 CDS AARI_11820 NC_014550.1 1315923 1316321 R hypothetical protein complement(1315923..1316321) Arthrobacter arilaitensis Re117 9795414 YP_003916363.1 CDS AARI_11830 NC_014550.1 1316490 1317386 D identified by match to protein family PF01656. chromosome partitioning protein; ParA family protein 1316490..1317386 Arthrobacter arilaitensis Re117 9795415 YP_003916364.1 CDS scpA NC_014550.1 1317386 1318288 D identified by match to protein family PF02616. ScpA participates in chromosomal partition during cell division. Component of a cohesin-like complex composed of scpA, scpB and smc; chromosome segregation and condensation protein A 1317386..1318288 Arthrobacter arilaitensis Re117 9795416 YP_003916365.1 CDS scpB NC_014550.1 1318281 1318871 D identified by match to protein family PIRSF019345. ScpB participates in chromosomal partition during cell division. Component of a cohesin-like complex composed of scpA, scpB and smc; chromosome segregation and condensation protein B 1318281..1318871 Arthrobacter arilaitensis Re117 9794378 YP_003916366.1 CDS AARI_11860 NC_014550.1 1318973 1320094 D identified by match to protein family PF00849. Pseudouridylate synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5- ribosyluracil, psi); pseudouridylate synthase 1318973..1320094 Arthrobacter arilaitensis Re117 9794379 YP_003916367.1 CDS tyrA NC_014550.1 1320098 1321198 D catalyses the following reaction: prephenate + NAD(+) <=> 4-hydroxyphenylpyruvate + CO(2) + NADH. Involved in tyrosine biosynthesis; prephenate dehydrogenase 1320098..1321198 Arthrobacter arilaitensis Re117 9795417 YP_003916368.1 CDS cmk NC_014550.1 1321195 1321875 D catalyzes the transfer of a phosphate group from ATP to either CMP or UMP to form CDP or UDP and ADP; cytidylate kinase 1321195..1321875 Arthrobacter arilaitensis Re117 9794485 YP_003916369.1 CDS engA NC_014550.1 1321941 1323473 D possible role in ribosome assembly and stability; GTP-binding protein EngA 1321941..1323473 Arthrobacter arilaitensis Re117 9793745 YP_003916370.1 CDS AARI_11900 NC_014550.1 1323749 1324591 D identified by match to protein family PF02567. PhzC/PhzF is involved in dimerisation of two 2, 3-dihydro-3- oxo-anthranilic acid molecules to create phenazine-1- carboxylic acid (PCA) by P. fluorescens. This family also contains a thymidilate synthase from Mycobacterium tuberculosis. Many phenazine compounds are found in nature and are produced by bacteria such as Pseudomonas spp., Streptomyces spp., and Pantoea agglomerans. These compounds have been implicated in the virulence and competitive fitness of producing organisms. For example, the phenazine pyocyanin produced by Pseudomonas aeruginosa contributes to its ability to colonise the lungs of cystic fibrosis patients. Similarly, phenazine-1-carboxylic acid, produced by a number of Pseudomonas, increases survival in soil environments and has been shown to be essential for the biological control activity of certain strains; phenazine biosynthesis protein PhzC/PhzF 1323749..1324591 Arthrobacter arilaitensis Re117 9793608 YP_003916371.1 CDS AARI_11910 NC_014550.1 1324801 1326507 D TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-2 (Drug RA2) family (TC 3.A.1.121.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family, ARE-subfamily (antibiotic resistance); drug resistance ATP-binding protein 1324801..1326507 Arthrobacter arilaitensis Re117 9795418 YP_003916372.1 CDS AARI_11920 NC_014550.1 1326750 1328639 D phenol 2-monooxygenase catalyzes the following reaction: Phenol + NADPH + O(2) => catechol + NADP(+) + H(2)O. Also active with resorcinol and o-cresol; phenol 2-monooxygenase 1326750..1328639 Arthrobacter arilaitensis Re117 9795419 YP_003916373.1 CDS AARI_11930 NC_014550.1 1328879 1329241 R hypothetical protein complement(1328879..1329241) Arthrobacter arilaitensis Re117 9795420 YP_003916374.1 CDS AARI_11940 NC_014550.1 1329509 1329961 D match to PF00498. The forkhead-associated (FHA) domain is a phosphopeptide recognition domain found in many regulatory proteins; FHA domain-containing protein 1329509..1329961 Arthrobacter arilaitensis Re117 9795421 YP_003916375.1 CDS AARI_11950 NC_014550.1 1330036 1330791 D identified by match to PF00376. Members of the family include the mercuric resistance operon regulatory protein merR; Bacillus subtilis bltR and bmrR; Bacillus glnR; Streptomyces coelicolor hspR; Bradyrhizobium japonicum nolA; Escherichia coli superoxide response regulator soxR; and Streptomyces lividans transcriptional activator tipA; MerR family transcriptional regulator 1330036..1330791 Arthrobacter arilaitensis Re117 9795422 YP_003916376.1 CDS AARI_11960 NC_014550.1 1330832 1331314 D hypothetical protein 1330832..1331314 Arthrobacter arilaitensis Re117 9795423 YP_003916377.1 CDS AARI_11970 NC_014550.1 1331556 1332149 D members of the MerR-family include the mercuric resistance operon regulatory protein merR; Bacillus subtilis bltR and bmrR; Bacillus glnR; Streptomyces coelicolor hspR; Bradyrhizobium japonicum nolA; Escherichia coli superoxide response regulator soxR; and Streptomyces lividans transcriptional activator tipA; MerR family transcriptional regulator 1331556..1332149 Arthrobacter arilaitensis Re117 9795424 YP_003916378.1 CDS AARI_11980 NC_014550.1 1332249 1333076 R identified by match to protein family PF01656. chromosome partitioning protein; ParA family protein complement(1332249..1333076) Arthrobacter arilaitensis Re117 9795425 YP_003916379.1 CDS pyc NC_014550.1 1333416 1336868 D biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate; pyruvate carboxylase 1333416..1336868 Arthrobacter arilaitensis Re117 9795426 YP_003916380.1 CDS AARI_12000 NC_014550.1 1336972 1337514 D hypothetical protein 1336972..1337514 Arthrobacter arilaitensis Re117 9794262 YP_003916381.1 CDS AARI_12010 NC_014550.1 1337487 1339298 R activates fatty acids by binding to coenzyme A. Possibly involved in the degradation of lipids via beta- oxidation; fatty-acid--CoA ligase complement(1337487..1339298) Arthrobacter arilaitensis Re117 9795427 YP_003916382.1 CDS AARI_12020 NC_014550.1 1339412 1339846 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1339412..1339846) Arthrobacter arilaitensis Re117 9795428 YP_003916383.1 CDS AARI_12030 NC_014550.1 1339843 1340616 R match to protein family PIRSF017388; esterase/lipase complement(1339843..1340616) Arthrobacter arilaitensis Re117 9795429 YP_003916384.1 CDS AARI_12040 NC_014550.1 1340750 1341421 D 1-acylglycerol-3-phosphate O-acyltransferase catalyzes the following reaction: Acyl-CoA + 1-acyl-sn- glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3- phosphate. It is involved in phospholipid biosynthesis; 1-acylglycerol-3-phosphate O-acyltransferase 1340750..1341421 Arthrobacter arilaitensis Re117 9795430 YP_003916385.1 CDS aroG NC_014550.1 1341503 1342897 D involved in phenylalanine, tyrosine and tryptophan biosynthesis; 3-deoxy-7-phosphoheptulonate synthase 1341503..1342897 Arthrobacter arilaitensis Re117 9795431 YP_003916386.1 CDS AARI_12060 NC_014550.1 1342969 1345185 R identified by match to protein domain PD000001. Match to PS00108 pattern. Protein kinases are a group of enzymes that possess a catalytic subunit which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. They play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiation; Ser/Thr protein kinase complement(1342969..1345185) Arthrobacter arilaitensis Re117 9793686 YP_003916387.1 CDS AARI_12070 NC_014550.1 1345388 1345636 R identified by match to protein family PF02467. WhiB is a transcription factor in Actinobacteria, required for differentiation and sporulation; WhiB family transcriptional regulator complement(1345388..1345636) Arthrobacter arilaitensis Re117 9795432 YP_003916388.1 CDS AARI_12080 NC_014550.1 1345994 1346407 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1345994..1346407 Arthrobacter arilaitensis Re117 9795433 YP_003916389.1 CDS AARI_12090 NC_014550.1 1346270 1350085 R match to PF01580. This domain is found extensively in a wide variety of proteins from prokaryotes and plasmids; FtsK/SpoIIIE domain-containing protein complement(1346270..1350085) Arthrobacter arilaitensis Re117 9795434 YP_003916390.1 CDS AARI_12100 NC_014550.1 1350334 1351557 D identified by match to protein domain PF00437; type II/IV secretion system protein E 1350334..1351557 Arthrobacter arilaitensis Re117 9795435 YP_003916391.1 CDS AARI_12110 NC_014550.1 1351560 1352411 D identified by match to protein domain PF00482; type II secretion system protein F 1351560..1352411 Arthrobacter arilaitensis Re117 9795436 YP_003916392.1 CDS AARI_12120 NC_014550.1 1352408 1353349 D identified by match to protein domain PF00482; type II secretion system protein F 1352408..1353349 Arthrobacter arilaitensis Re117 9795437 YP_003916393.1 CDS AARI_12130 NC_014550.1 1353412 1353645 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 1353412..1353645 Arthrobacter arilaitensis Re117 9795438 YP_003916394.1 CDS AARI_12140 NC_014550.1 1353691 1354071 D identified by match to protein family PF07811. The members of this family are similar to a region of the protein product of the bacterial tadE locus. In various bacterial species, the tad locus is closely linked to flp- like genes, which encode proteins required for the production of pili involved in adherence to surfaces. It is thought that the tad loci encode proteins that act to assemble or export an Flp pilus in various bacteria; TadE-like family protein 1353691..1354071 Arthrobacter arilaitensis Re117 9795439 YP_003916395.1 CDS AARI_12150 NC_014550.1 1354025 1354510 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 1354025..1354510 Arthrobacter arilaitensis Re117 9795440 YP_003916396.1 CDS AARI_12160 NC_014550.1 1354560 1354958 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.997) with cleavage site probability 0.440 between position 27 and 28; hypothetical protein 1354560..1354958 Arthrobacter arilaitensis Re117 9795441 YP_003916397.1 CDS prfB NC_014550.1 1355226 1356341 D directs the termination of translation in response to the peptide chain termination codons UGA and UAA; peptide chain release factor 2 1355226..1356341 Arthrobacter arilaitensis Re117 9795442 YP_003916398.1 CDS ftsE NC_014550.1 1356622 1357419 D TCDB: general secretory pathway (Sec) family, general secretory pathway (Sec-SRP) complex (TC 3.A.5.1.1). ABCISSE: ATP-binding protein (ABC), CDI- family. CDI family systems are found only in eubacteria and are comprised of two proteins: the FtsE ATP-binding protein and the FtsX permease. It is possible that CDI systems play a role in the proper membrane targeting or insertion of some proteins essential for septum formation; cell division ATP-binding protein FtsE 1356622..1357419 Arthrobacter arilaitensis Re117 9794221 YP_003916399.1 CDS ftsX NC_014550.1 1357416 1358330 D ABCISSE: IM (permease), CDI-family. CDI family systems are found only in eubacteria and are comprised of two proteins: the FtsE ATP-binding protein and the FtsX permease. It is possible that CDI systems play a role in the proper membrane targeting or insertion of some proteins essential for septum formation; cell division membrane protein FtsX 1357416..1358330 Arthrobacter arilaitensis Re117 9793864 YP_003916400.1 CDS AARI_12200 NC_014550.1 1358383 1359846 D identified by match to protein family PF01551. Members of this family are zinc metallopeptidases with a range of specificities. Peptidase family M23 are also endopeptidases. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 1. 000 between position 32 and 33; peptidase M23 1358383..1359846 Arthrobacter arilaitensis Re117 9793869 YP_003916401.1 CDS smpB NC_014550.1 1359901 1360380 D in bacteria, SsrA RNA recognizes ribosomes stalled on defective messages and acts as a tRNA and mRNA to mediate the addition of a short peptide tag to the C- terminus of the partially synthesized nascent polypeptide chain. The SsrA-tagged protein is then degraded by C- terminal-specific proteases. SmpB binds specifically to the ssrA RNA and is required for stable association of ssrA with ribosomes; SsrA-binding protein 1359901..1360380 Arthrobacter arilaitensis Re117 9795443 YP_003916402.1 CDS AARI_12220 NC_014550.1 1360987 1362117 D match to protein family PF00589; phage integrase 1360987..1362117 Arthrobacter arilaitensis Re117 9794398 YP_003916403.1 CDS AARI_12230 NC_014550.1 1362176 1362703 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.718 between position 29 and 30; hypothetical protein complement(1362176..1362703) Arthrobacter arilaitensis Re117 9795444 YP_003916404.1 CDS AARI_12240 NC_014550.1 1364784 1365257 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1364784..1365257 Arthrobacter arilaitensis Re117 9793425 YP_003916405.1 CDS AARI_12250 NC_014550.1 1365306 1365686 R identified by match to protein family PF02537. CrcB is a integral membrane protein possibly involved in chromosome condensation. Overexpression in E. coli also leads to camphor resistance; CrcB-like protein complement(1365306..1365686) Arthrobacter arilaitensis Re117 9795446 YP_003916406.1 CDS AARI_12260 NC_014550.1 1365686 1366147 R identified by match to protein family PF02537. CrcB is a integral membrane protein possibly involved in chromosome condensation. Overexpression in E. coli also leads to camphor resistance; CrcB-like protein complement(1365686..1366147) Arthrobacter arilaitensis Re117 9795447 YP_003916407.1 CDS AARI_12270 NC_014550.1 1366159 1366638 R identified by match to PF00582: universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general stress endurance activity; universal stress family domain-containing protein complement(1366159..1366638) Arthrobacter arilaitensis Re117 9795448 YP_003916408.1 CDS AARI_12280 NC_014550.1 1366710 1367339 R identified by match to PF01325 and PF02742. The diphtheria toxin repressor protein (DTXR) is a member of this group. In Corynebacterium diphtheriae where it has been studied in some detail this protein acts as an iron- binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. The N- terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation; metal-dependent transcriptional regulator complement(1366710..1367339) Arthrobacter arilaitensis Re117 9795449 YP_003916409.1 CDS AARI_12290 NC_014550.1 1367352 1368158 R catalyses the following reaction: L-histidinol phosphate + H(2)O <=> L-histidinol + phosphate. Involved in histidine biosynthesis; histidinol-phosphatase complement(1367352..1368158) Arthrobacter arilaitensis Re117 9795450 YP_003916410.1 CDS AARI_12300 NC_014550.1 1368174 1369265 R identified by match to protein family PF03193; ribosome-associated GTPase complement(1368174..1369265) Arthrobacter arilaitensis Re117 9795451 YP_003916411.1 CDS aroA NC_014550.1 1369265 1370668 R sixth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1369265..1370668) Arthrobacter arilaitensis Re117 9795452 YP_003916412.1 CDS rpoE NC_014550.1 1370727 1371530 D the sigma factor RpoE is involved in heat shock and oxidative stress response; it is believed to control protein processing in the extracytoplasmic compartment; RNA polymerase sigma factor RpoE 1370727..1371530 Arthrobacter arilaitensis Re117 9793682 YP_003916413.1 CDS AARI_12330 NC_014550.1 1371532 1371792 D may act on RpoE. Match to protein family TIGR02949. Anti-sigma factors bind to sigma factors and inhibit their transcriptional activity; anti-sigma factor 1371532..1371792 Arthrobacter arilaitensis Re117 9794346 YP_003916414.1 CDS AARI_12340 NC_014550.1 1372039 1372728 R match to protein family SSF52266; lipase/esterase complement(1372039..1372728) Arthrobacter arilaitensis Re117 9795453 YP_003916415.1 CDS sucA NC_014550.1 1372861 1376613 R it is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61 (Dihydrolipoyllysine-residue succinyltransferase), which also binds multiple copies of EC 1.8.1.4 (Dihydrolipoyl dehydrogenase). Involved in the TCA cycle; oxoglutarate dehydrogenase (succinyl-transferring) complement(1372861..1376613) Arthrobacter arilaitensis Re117 9795454 YP_003916416.1 CDS AARI_12360 NC_014550.1 1377043 1378365 D possible transporter. Match to PF00571 (CBS domain pair); CBS domain-containing transporter 1377043..1378365 Arthrobacter arilaitensis Re117 9794409 YP_003916417.1 CDS AARI_12370 NC_014550.1 1378370 1379431 D match to PF00571 (CBS domain pair); CBS domain-containing protein 1378370..1379431 Arthrobacter arilaitensis Re117 9795455 YP_003916418.1 CDS AARI_12380 NC_014550.1 1379562 1380395 D TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, ATP- binding protein (ABC), MET-family. This family is comprised of systems involved in the uptake of various metallic cations such as iron, manganese and zinc; iron/manganese/zinc ABC transporter ATP-binding subunit 1379562..1380395 Arthrobacter arilaitensis Re117 9795456 YP_003916419.1 CDS AARI_12390 NC_014550.1 1380405 1381262 D TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, permease (IM), MET-family. This family is comprised of systems involved in the uptake of various metallic cations such as iron, manganese and zinc; iron/manganese/zinc ABC transporter inner membrane subunit 1380405..1381262 Arthrobacter arilaitensis Re117 9795457 YP_003916420.1 CDS AARI_12400 NC_014550.1 1381338 1381976 D hypothetical protein 1381338..1381976 Arthrobacter arilaitensis Re117 9795458 YP_003916421.1 CDS AARI_12410 NC_014550.1 1382044 1383504 R identified by match to SM00507; HNH endonuclease domain-containing protein complement(1382044..1383504) Arthrobacter arilaitensis Re117 9795459 YP_003916422.1 CDS AARI_12420 NC_014550.1 1383616 1384041 R match to protein family PF01475; metal uptake regulation protein complement(1383616..1384041) Arthrobacter arilaitensis Re117 9795460 YP_003916423.1 CDS AARI_12430 NC_014550.1 1384194 1384895 D identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase 1384194..1384895 Arthrobacter arilaitensis Re117 9795461 YP_003916424.1 CDS AARI_12440 NC_014550.1 1384895 1385731 D thiosulfate sulfurtransferase 1384895..1385731 Arthrobacter arilaitensis Re117 9795462 YP_003916425.1 CDS AARI_12450 NC_014550.1 1385761 1386189 D match to PF01230: histidine triad motif. The histidine triad motif (HIT) is related to the sequence H- phi-H-phi-H-phi-phi (where phi is a hydrophobic amino acid). Proteins containing HIT domains form a superfamily of nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides; histidine triad family protein 1385761..1386189 Arthrobacter arilaitensis Re117 9795463 YP_003916426.1 CDS AARI_12460 NC_014550.1 1386192 1386608 D hypothetical protein 1386192..1386608 Arthrobacter arilaitensis Re117 9795464 YP_003916427.1 CDS hrpA NC_014550.1 1386583 1390542 R identified by similarity to protein SP:P43329 (Escherichia coli); ATP-dependent helicase HrpA complement(1386583..1390542) Arthrobacter arilaitensis Re117 9795465 YP_003916428.1 CDS AARI_12480 NC_014550.1 1390941 1391936 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, binding protein (BP), MOS-family (monosaccharides: pentoses and hexoses); sugar ABC transporter substrate-binding protein 1390941..1391936 Arthrobacter arilaitensis Re117 9793977 YP_003916429.1 CDS AARI_12490 NC_014550.1 1392036 1392956 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, permease (IM), MOS-family (monosaccharides: pentoses and hexoses); sugar ABC transporter inner membrane subunit 1392036..1392956 Arthrobacter arilaitensis Re117 9795466 YP_003916430.1 CDS AARI_12500 NC_014550.1 1392949 1393740 D TCDB: ATP-binding cassette (ABC) superfamily (TC 3. A.1.y.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), NO family (NO family systems represent few ABC proteins with unknown function and which are apparently unrelated to existent families); sugar ABC transporter ATP-binding subunit 1392949..1393740 Arthrobacter arilaitensis Re117 9795467 YP_003916431.1 CDS AARI_12520 NC_014550.1 1394688 1395167 R hypothetical protein complement(1394688..1395167) Arthrobacter arilaitensis Re117 9795469 YP_003916432.1 CDS AARI_12530 NC_014550.1 1395348 1396544 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(1395348..1396544) Arthrobacter arilaitensis Re117 9795470 YP_003916433.1 CDS AARI_12540 NC_014550.1 1396681 1397034 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1396681..1397034) Arthrobacter arilaitensis Re117 9795471 YP_003916434.1 CDS AARI_12550 NC_014550.1 1397180 1397683 R hypothetical protein complement(1397180..1397683) Arthrobacter arilaitensis Re117 9795472 YP_003916435.1 CDS AARI_12560 NC_014550.1 1397781 1398503 R 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1397781..1398503) Arthrobacter arilaitensis Re117 9795473 YP_003916436.1 CDS argS NC_014550.1 1398869 1400512 D activates arginine and transfers it to tRNA(Arg) as the first step in protein biosynthesis; arginine--tRNA ligase 1398869..1400512 Arthrobacter arilaitensis Re117 9793609 YP_003916437.1 CDS lysA NC_014550.1 1400519 1401940 D catalyzes the conversion of diaminopimelic acid into lysine, the last step in the biosynthesis of lysine; diaminopimelate decarboxylase 1400519..1401940 Arthrobacter arilaitensis Re117 9793681 YP_003916438.1 CDS thrA NC_014550.1 1401941 1403227 D catalyzes NAD-dependent reduction of aspartate 4- semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. The latter participates in the biosynthesis of threonine and then isoleucine as well as in that of methionine; homoserine dehydrogenase 1401941..1403227 Arthrobacter arilaitensis Re117 9794049 YP_003916439.1 CDS thrC NC_014550.1 1403229 1404329 D catalyzes the formation of threonine from homoserine-phosphate; threonine synthase 1403229..1404329 Arthrobacter arilaitensis Re117 9794448 YP_003916440.1 CDS thrB NC_014550.1 1404461 1405393 D catalyses the formation of O-phospho-L-homoserine from homoserine. Involved in the biosynthesis of threonine; homoserine kinase 1404461..1405393 Arthrobacter arilaitensis Re117 9794450 YP_003916441.1 CDS rho NC_014550.1 1405728 1407995 D facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho RNA-dependent ATPase activity, and release of the mRNA from the DNA template; transcription termination factor Rho 1405728..1407995 Arthrobacter arilaitensis Re117 9794449 YP_003916442.1 CDS prfA NC_014550.1 1408184 1409257 D directs the termination of translation in response to the peptide chain termination codons UGA and UAA; peptide chain release factor 1 1408184..1409257 Arthrobacter arilaitensis Re117 9794294 YP_003916443.1 CDS hemK NC_014550.1 1409265 1410122 D HemK methylates the translation termination release factors RF1 and RF2, which plays a pivotal role in the termination of translation; methylase of peptide chain release factors 1409265..1410122 Arthrobacter arilaitensis Re117 9794220 YP_003916444.1 CDS AARI_12650 NC_014550.1 1410157 1410840 D Sua5 family translation factor 1410157..1410840 Arthrobacter arilaitensis Re117 9793958 YP_003916445.1 CDS AARI_12660 NC_014550.1 1410837 1411958 D match to protein family PF00953. Catalyzes the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl- pentapeptide from UDP-MurNAc-pentapeptide and undecaprenyl- phosphate. Involved in peptidoglycan biosynthesis; phospho-N-acetylmuramoyl-pentapeptide- transferase 1410837..1411958 Arthrobacter arilaitensis Re117 9795475 YP_003916446.1 CDS AARI_12670 NC_014550.1 1412128 1412562 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1412128..1412562 Arthrobacter arilaitensis Re117 9795476 YP_003916447.1 CDS atpB NC_014550.1 1412828 1413640 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit A 1412828..1413640 Arthrobacter arilaitensis Re117 9795477 YP_003916448.1 CDS atpE NC_014550.1 1413748 1413960 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit C 1413748..1413960 Arthrobacter arilaitensis Re117 9793700 YP_003916449.1 CDS atpF NC_014550.1 1414041 1414595 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit B 1414041..1414595 Arthrobacter arilaitensis Re117 9793703 YP_003916450.1 CDS atpH NC_014550.1 1414595 1415407 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit delta 1414595..1415407 Arthrobacter arilaitensis Re117 9793704 YP_003916451.1 CDS atpA NC_014550.1 1415534 1417171 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit alpha 1415534..1417171 Arthrobacter arilaitensis Re117 9793706 YP_003916452.1 CDS atpG NC_014550.1 1417247 1418140 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit gamma 1417247..1418140 Arthrobacter arilaitensis Re117 9793699 YP_003916453.1 CDS atpD NC_014550.1 1418177 1419622 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit beta 1418177..1419622 Arthrobacter arilaitensis Re117 9793705 YP_003916454.1 CDS atpC NC_014550.1 1419625 1419894 D H(+)-transporting two-sector ATPase (also named ATP synthase or ATPase) is composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilon), while the F0 ATPase complex is the membrane- embedded proton channel that is composed of at least 3 subunits (A-C). It uses a proton gradient to drive ATP synthesis and hydrolyzes ATP to build the proton gradient; H(+)-transporting two-sector ATPase subunit epsilon 1419625..1419894 Arthrobacter arilaitensis Re117 9793702 YP_003916455.1 CDS AARI_12760 NC_014550.1 1419903 1420331 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 1419903..1420331 Arthrobacter arilaitensis Re117 9793701 YP_003916456.1 CDS AARI_12770 NC_014550.1 1420473 1421594 D identified by match to protein family PF01370: NAD dependent epimerase/dehydratase family. This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; NAD dependent epimerase/dehydratase family protein 1420473..1421594 Arthrobacter arilaitensis Re117 9795478 YP_003916457.1 CDS nagA NC_014550.1 1421458 1422666 R catalyzes the hydrolysis of N-acetylglucosamine-6- phosphate to glucosamine-6-phosphate and acetate; N-acetylglucosamine-6-phosphate deacetylase complement(1421458..1422666) Arthrobacter arilaitensis Re117 9795479 YP_003916458.1 CDS AARI_12790 NC_014550.1 1422846 1423592 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(1422846..1423592) Arthrobacter arilaitensis Re117 9794131 YP_003916459.1 CDS AARI_12800 NC_014550.1 1423756 1424451 R hypothetical protein complement(1423756..1424451) Arthrobacter arilaitensis Re117 9795480 YP_003916460.1 CDS AARI_12810 NC_014550.1 1424511 1424882 D hypothetical protein 1424511..1424882 Arthrobacter arilaitensis Re117 9795481 YP_003916461.1 CDS AARI_12820 NC_014550.1 1424905 1426275 R 9 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1424905..1426275) Arthrobacter arilaitensis Re117 9795482 YP_003916462.1 CDS AARI_12830 NC_014550.1 1426455 1428167 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1426455..1428167 Arthrobacter arilaitensis Re117 9795483 YP_003916463.1 CDS AARI_12840 NC_014550.1 1428173 1429084 D thioredoxin 1428173..1429084 Arthrobacter arilaitensis Re117 9795484 YP_003916464.1 CDS AARI_12850 NC_014550.1 1429220 1429978 D TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC), DRI-family, DRB-subfamily (drug resistance, ). Possible function in drug efflux; drug resistance ATP-binding protein 1429220..1429978 Arthrobacter arilaitensis Re117 9795485 YP_003916465.1 CDS AARI_12860 NC_014550.1 1429960 1431525 D TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM), DRI-family, DRB-subfamily (drug resistance, ). Possible function in drug efflux; drug ABC transporter inner membrane subunit 1429960..1431525 Arthrobacter arilaitensis Re117 9795486 YP_003916466.1 CDS AARI_12870 NC_014550.1 1431827 1432078 D hypothetical protein 1431827..1432078 Arthrobacter arilaitensis Re117 9795487 YP_003916467.1 CDS AARI_12880 NC_014550.1 1432134 1433900 D possible DNA or RNA helicase; ATP-dependent helicase 1432134..1433900 Arthrobacter arilaitensis Re117 9795488 YP_003916468.1 CDS pncA NC_014550.1 1434152 1434745 R nicotinamidase converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD); nicotinamidase complement(1434152..1434745) Arthrobacter arilaitensis Re117 9795489 YP_003916469.1 CDS pncB NC_014550.1 1434850 1436148 R nicotinate phosphoribosyltransferase catalyses the formation of nicotinate D-ribonucleotide and PPi from 5- phospho-alpha-D-ribose 1-diphosphate and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products; nicotinate phosphoribosyltransferase complement(1434850..1436148) Arthrobacter arilaitensis Re117 9794208 YP_003916470.1 CDS clpS NC_014550.1 1436291 1436575 D involved in the modulation of the specificity of the clpAP-mediated ATP-dependent protein degradation; ATP-dependent Clp protease adaptor protein ClpS 1436291..1436575 Arthrobacter arilaitensis Re117 9794209 YP_003916471.1 CDS AARI_12920 NC_014550.1 1436578 1437156 D hypothetical protein 1436578..1437156 Arthrobacter arilaitensis Re117 9793742 YP_003916472.1 CDS murI NC_014550.1 1437161 1438084 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1437161..1438084 Arthrobacter arilaitensis Re117 9795490 YP_003916473.1 CDS AARI_12940 NC_014550.1 1438081 1439022 D hypothetical protein 1438081..1439022 Arthrobacter arilaitensis Re117 9794123 YP_003916474.1 CDS rph NC_014550.1 1439682 1440416 D removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates; tRNA nucleotidyltransferase 1439682..1440416 Arthrobacter arilaitensis Re117 9795492 YP_003916475.1 CDS rdgB NC_014550.1 1440413 1441045 D hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions; nucleoside-triphosphatase 1440413..1441045 Arthrobacter arilaitensis Re117 9794308 YP_003916476.1 CDS AARI_12980 NC_014550.1 1441126 1442031 R hypothetical protein complement(1441126..1442031) Arthrobacter arilaitensis Re117 9794285 YP_003916477.1 CDS AARI_12990 NC_014550.1 1442625 1442984 D identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator 1442625..1442984 Arthrobacter arilaitensis Re117 9795493 YP_003916478.1 CDS AARI_13000 NC_014550.1 1443014 1443931 D TCDB: ATP-binding cassette (ABC) superfamily (TC 3. A.1.y.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), NO family (NO family systems represent few ABC proteins with unknown function and which are apparently unrelated to existent families); ABC transporter ATP-binding subunit 1443014..1443931 Arthrobacter arilaitensis Re117 9795494 YP_003916479.1 CDS AARI_13010 NC_014550.1 1443928 1444623 D TC 3.1.y.z. ABCISSE: ABC transporter, permease (IM); ABC transporter inner membrane subunit 1443928..1444623 Arthrobacter arilaitensis Re117 9795495 YP_003916480.1 CDS AARI_13020 NC_014550.1 1444814 1445311 D hypothetical protein 1444814..1445311 Arthrobacter arilaitensis Re117 9795496 YP_003916481.1 CDS AARI_13030 NC_014550.1 1445525 1446526 D DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit epsilon 1445525..1446526 Arthrobacter arilaitensis Re117 9795497 YP_003916482.1 CDS AARI_13040 NC_014550.1 1446607 1447542 R hypothetical protein complement(1446607..1447542) Arthrobacter arilaitensis Re117 9795498 YP_003916483.1 CDS sbcD NC_014550.1 1447594 1448760 D SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3 ->5 double strand exonuclease that can open hairpins. It also has a 5 single-strand endonuclease activity; nuclease SbcCD subunit D 1447594..1448760 Arthrobacter arilaitensis Re117 9795499 YP_003916484.1 CDS sbcC NC_014550.1 1448757 1451828 D SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3 ->5 double strand exonuclease that can open hairpins. It also has a 5 single-strand endonuclease activity; nuclease SbcCD subunit C 1448757..1451828 Arthrobacter arilaitensis Re117 9794375 YP_003916485.1 CDS AARI_13070 NC_014550.1 1451941 1453215 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 1451941..1453215 Arthrobacter arilaitensis Re117 9794374 YP_003916486.1 CDS AARI_13080 NC_014550.1 1453321 1454016 R identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator complement(1453321..1454016) Arthrobacter arilaitensis Re117 9795500 YP_003916487.1 CDS AARI_13090 NC_014550.1 1454280 1455620 D major facilitator superfamily (MFS), metabolite:H+ symporter (MHS) family (TC 2.A.1.6.z); MFS superfamily transporter 1454280..1455620 Arthrobacter arilaitensis Re117 9795501 YP_003916488.1 CDS AARI_13100 NC_014550.1 1456546 1457043 D hypothetical protein 1456546..1457043 Arthrobacter arilaitensis Re117 9795502 YP_003916489.1 CDS AARI_13110 NC_014550.1 1457063 1457314 D hypothetical protein 1457063..1457314 Arthrobacter arilaitensis Re117 9795503 YP_003916490.1 CDS AARI_13120 NC_014550.1 1457507 1458514 R match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator complement(1457507..1458514) Arthrobacter arilaitensis Re117 9795504 YP_003916491.1 CDS AARI_13130 NC_014550.1 1458628 1460283 R enzymes of this family comprise mostly alpha- amylases (EC 3.2.1.1); pullulanases (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); glycosyl hydrolase family 13 complement(1458628..1460283) Arthrobacter arilaitensis Re117 9795505 YP_003916492.1 CDS AARI_13140 NC_014550.1 1460583 1461851 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, binding protein (BP), OSP-family (oligosaccharides or polyols), maltooligosaccharides import; maltooligosaccharides ABC transporter substrate-binding protein 1460583..1461851 Arthrobacter arilaitensis Re117 9795506 YP_003916493.1 CDS AARI_13150 NC_014550.1 1461968 1463563 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, permease (IM), OSP- family (oligosaccharides or polyols), maltooligosaccharides import; maltooligosaccharides ABC transporter inner membrane subunit 1461968..1463563 Arthrobacter arilaitensis Re117 9795507 YP_003916494.1 CDS AARI_13160 NC_014550.1 1463563 1464477 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, permease (IM), OSP- family (oligosaccharides or polyols), maltooligosaccharides import; maltooligosaccharides ABC transporter inner membrane subunit 1463563..1464477 Arthrobacter arilaitensis Re117 9795508 YP_003916495.1 CDS AARI_13170 NC_014550.1 1464579 1465568 D 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1464579..1465568 Arthrobacter arilaitensis Re117 9795509 YP_003916496.1 CDS AARI_13180 NC_014550.1 1465624 1466379 D identified by match to protein domains PF02909 and PF00440; TetR family transcriptional regulator 1465624..1466379 Arthrobacter arilaitensis Re117 9795510 YP_003916497.1 CDS AARI_13190 NC_014550.1 1466480 1468036 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 1466480..1468036 Arthrobacter arilaitensis Re117 9795511 YP_003916498.1 CDS AARI_13200 NC_014550.1 1468080 1468496 D hypothetical protein 1468080..1468496 Arthrobacter arilaitensis Re117 9795512 YP_003916499.1 CDS AARI_13210 NC_014550.1 1468519 1469619 R identified by match to PF00487. Fatty acid desaturases catalyze the insertion of a double bond at the delta position of fatty acids; fatty acid desaturase complement(1468519..1469619) Arthrobacter arilaitensis Re117 9795513 YP_003916500.1 CDS AARI_13220 NC_014550.1 1469747 1471387 R TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-1 (Drug RA1) family (TC 3.A.1.120.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family. Duplicated ATPase domains (PF00005); drug resistance ATP-binding protein complement(1469747..1471387) Arthrobacter arilaitensis Re117 9795514 YP_003916501.1 CDS AARI_13230 NC_014550.1 1471471 1471836 D identified by match to PF01022. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator 1471471..1471836 Arthrobacter arilaitensis Re117 9795515 YP_003916502.1 CDS AARI_34840 NC_014550.1 1472330 1473607 R transposase of ISAar13, ISL3 family complement(1472330..1473607) Arthrobacter arilaitensis Re117 9795516 YP_003916503.1 CDS AARI_13250 NC_014550.1 1474555 1475217 R match to protein domain PF00156. This family includes a range of diverse phosphoribosyl transferase enzymes; phosphoribosyl transferase complement(1474555..1475217) Arthrobacter arilaitensis Re117 9795517 YP_003916504.1 CDS hpaD NC_014550.1 1476668 1477777 R involved in the catabolism of tyrosine; 3,4-dihydroxyphenylacetate 2,3-dioxygenase complement(1476668..1477777) Arthrobacter arilaitensis Re117 9795520 YP_003916505.1 CDS hpaE NC_014550.1 1477829 1479322 R 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase catalyzes the formation of 5-carboxymethyl-2- hydroxymuconate from 5-carboxymethyl-2-hydroxymuconate semialdehyde; 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase complement(1477829..1479322) Arthrobacter arilaitensis Re117 9793971 YP_003916506.1 CDS AARI_13300 NC_014550.1 1479397 1480056 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(1479397..1480056) Arthrobacter arilaitensis Re117 9793972 YP_003916507.1 CDS AARI_13310 NC_014550.1 1480056 1481558 R involved in the homoprotocatechuic acid pathway. EC 5.3.3.10 (5-carboxymethyl-2-hydroxymuconate Delta- isomerase ) catalyses the conversion of 5-carboxymethyl- 2hydroxymuconate to 5-carboxy-2-oxohept-3-enedioate. The latter is converted to 2-hydroxyhepta-2,4-dienediotae by EC 4.1.1.68 (5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase); homoprotocatechuate catabolism bifunctional isomerase/decarboxylase complement(1480056..1481558) Arthrobacter arilaitensis Re117 9795521 YP_003916508.1 CDS AARI_13320 NC_014550.1 1481933 1483168 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM); ABC transporter inner membrane subunit complement(1481933..1483168) Arthrobacter arilaitensis Re117 9795522 YP_003916509.1 CDS AARI_13330 NC_014550.1 1483165 1483872 R TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC); ABC transporter ATP-binding subunit complement(1483165..1483872) Arthrobacter arilaitensis Re117 9795523 YP_003916510.1 CDS AARI_13340 NC_014550.1 1483862 1484872 R hypothetical protein complement(1483862..1484872) Arthrobacter arilaitensis Re117 9795524 YP_003916511.1 CDS AARI_34850 NC_014550.1 1484869 1486176 R transposase of ISAar19, ISL3 family complement(1484869..1486176) Arthrobacter arilaitensis Re117 9795525 YP_003916512.1 CDS AARI_34860 NC_014550.1 1487062 1488360 D transposase of ISAar10, IS1380 family 1487062..1488360 Arthrobacter arilaitensis Re117 9793427 YP_003916513.1 CDS AARI_34870 NC_014550.1 1494772 1496217 D transposase of ISAar22, IS481 family 1494772..1496217 Arthrobacter arilaitensis Re117 9795528 YP_003916514.1 CDS AARI_13380 NC_014550.1 1496480 1497772 D match to protein family PF04464. Possibly involved in teichoic acid biosynthesis; transferase 1496480..1497772 Arthrobacter arilaitensis Re117 9793429 YP_003916515.1 CDS AARI_34880 NC_014550.1 1498112 1499548 D transposase of ISAar9, IS1380 family 1498112..1499548 Arthrobacter arilaitensis Re117 9795529 YP_003916516.1 CDS ilvD NC_014550.1 1499903 1501831 R involved in the biosynthesis of isoleucine, leucine and valine. Catalyses the dehydratation of 2, 3-dihydroxy-3- methylpentanoate and 2, 3-dihydroxy-3-methylbutanoate into 3-methyl-2-oxopentanoate and 2-oxoisovalerate, respectively; dihydroxy-acid dehydratase complement(1499903..1501831) Arthrobacter arilaitensis Re117 9793430 YP_003916517.1 CDS AARI_13400 NC_014550.1 1501917 1502696 D identified by match to SM00530: Helix-turn-helix XRE-family like proteins. This is a large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); DNA-binding protein 1501917..1502696 Arthrobacter arilaitensis Re117 9794005 YP_003916518.1 CDS AARI_13410 NC_014550.1 1502860 1503552 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.646 between position 58 and 59; hypothetical protein complement(1502860..1503552) Arthrobacter arilaitensis Re117 9795530 YP_003916519.1 CDS AARI_13420 NC_014550.1 1503817 1504566 R match to PS00120 pattern: lipases, serine active site; lipase/esterase complement(1503817..1504566) Arthrobacter arilaitensis Re117 9795531 YP_003916520.1 CDS AARI_13430 NC_014550.1 1504570 1505151 R hypothetical protein complement(1504570..1505151) Arthrobacter arilaitensis Re117 9795532 YP_003916521.1 CDS AARI_13440 NC_014550.1 1505358 1506086 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 1505358..1506086 Arthrobacter arilaitensis Re117 9795533 YP_003916522.1 CDS nadA NC_014550.1 1506138 1507427 D quinolinate synthetase A subunit. Quinolinate synthetase complex (A and B subunits) is involved in the de novo biosynthetic pathway of pyridine nucleotide formation. It catalyses the formation of quinolinic acid; quinolinate synthetase A subunit 1506138..1507427 Arthrobacter arilaitensis Re117 9795534 YP_003916523.1 CDS nadB NC_014550.1 1507424 1509067 D quinolinate synthetase B subunit. Quinolinate synthetase complex (A and B subunits) is involved in the de novo biosynthetic pathway of pyridine nucleotide formation. It catalyses the formation of quinolinic acid; L-aspartate oxidase 1507424..1509067 Arthrobacter arilaitensis Re117 9794126 YP_003916524.1 CDS nadC NC_014550.1 1509064 1509930 D involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate in the presence of Mg2+ to produce nicotinic acid mononucleotide, pyrophosphate and carbon dioxide; nicotinate-nucleotide diphosphorylase 1509064..1509930 Arthrobacter arilaitensis Re117 9794127 YP_003916525.1 CDS AARI_13480 NC_014550.1 1509927 1511069 D identified by match to protein family PIRSF005572: cysteine desulfurase, NifS type. Cysteine desulfurase catalyses the following reaction: L-cysteine + [enzyme]- cysteine <=> L-alanine + [enzyme]-S-sulfanylcysteine. It is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) and functions by mobilizing sulfur; cysteine desulfurase 1509927..1511069 Arthrobacter arilaitensis Re117 9794128 YP_003916526.1 CDS AARI_13490 NC_014550.1 1511315 1512127 D match to PF08239: bacterial SH3 domain. A homologue of the SH3 domain has been found in a number of different bacterial proteins including glycyl-glycine endopeptidase, bacteriocin and some hypothetical proteins. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.938 between position 26 and 27; SH3 domain-containing protein 1511315..1512127 Arthrobacter arilaitensis Re117 9795535 YP_003916527.1 CDS AARI_13500 NC_014550.1 1512205 1512789 D match to PF08239: bacterial SH3 domain. A homologue of the SH3 domain has been found in a number of different bacterial proteins including glycyl-glycine endopeptidase, bacteriocin and some hypothetical proteins; SH3 domain-containing protein 1512205..1512789 Arthrobacter arilaitensis Re117 9795536 YP_003916528.1 CDS AARI_13510 NC_014550.1 1512873 1514300 R N-terminal section of the protein: match to protein family PF02557 (VanY, D-alanyl-D-alanine carboxypeptidase). C-terminal section of the protein: match to PF08239 (bacterial SH3 domain) protein family PF02557; D-alanyl-D-alanine carboxypeptidase complement(1512873..1514300) Arthrobacter arilaitensis Re117 9795537 YP_003916529.1 CDS AARI_13520 NC_014550.1 1514739 1515254 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 1514739..1515254 Arthrobacter arilaitensis Re117 9795538 YP_003916530.1 CDS AARI_13530 NC_014550.1 1515319 1515795 D match to protein family PF08327; activator of Hsp90 ATPase 1-like protein 1515319..1515795 Arthrobacter arilaitensis Re117 9795539 YP_003916531.1 CDS AARI_13540 NC_014550.1 1515808 1516401 R match to protein domain PF01872. This domain is found in the C-terminus of the bifunctional deaminase- reductase in combination with PF00383 as well as in isolation in some archaebacterial proteins; RibD domain-containing protein complement(1515808..1516401) Arthrobacter arilaitensis Re117 9795540 YP_003916532.1 CDS AARI_13550 NC_014550.1 1516513 1517202 R hypothetical protein complement(1516513..1517202) Arthrobacter arilaitensis Re117 9795541 YP_003916533.1 CDS AARI_13560 NC_014550.1 1517327 1517785 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(1517327..1517785) Arthrobacter arilaitensis Re117 9795542 YP_003916534.1 CDS AARI_13570 NC_014550.1 1517769 1518902 R identified by match to PF00296. Bacterial luciferase is a flavin monooxygenase that catalyses the oxidation of long-chain aldehydes and releases energy in the form of visible light, and which uses flavin as a substrate rather than a cofactor. There are structural similarities between bacterial luciferase and nonfluorescent flavoproteins (LuxF, FP390), alkanesulfonate monooxygenase (SsuD), and coenzyme F420- dependent terahydromethanopterin reductase, which make up clearly related families with somewhat different folds; luciferase-like monooxygenase complement(1517769..1518902) Arthrobacter arilaitensis Re117 9795543 YP_003916535.1 CDS AARI_13580 NC_014550.1 1519019 1519687 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(1519019..1519687) Arthrobacter arilaitensis Re117 9795544 YP_003916536.1 CDS AARI_13590 NC_014550.1 1519834 1520568 D 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1519834..1520568 Arthrobacter arilaitensis Re117 9795545 YP_003916537.1 CDS AARI_13600 NC_014550.1 1520653 1524030 R Resistance-Nodulation-Cell Division (RND) superfamily (TC 2.A.6.y.z). Match to protein family PF00873 (AcrB/AcrD/AcrF family). Some Members of this family are involved in drug resistance; drug exporter of the RND superfamily complement(1520653..1524030) Arthrobacter arilaitensis Re117 9795546 YP_003916538.1 CDS AARI_34890 NC_014550.1 1524302 1525747 D transposase of ISAar22, IS481 family 1524302..1525747 Arthrobacter arilaitensis Re117 9795547 YP_003916539.1 CDS AARI_13620 NC_014550.1 1526694 1526972 D hypothetical protein 1526694..1526972 Arthrobacter arilaitensis Re117 9795548 YP_003916540.1 CDS mqo NC_014550.1 1527042 1528529 R other name: malate:quinone oxidoreductase. Takes part in the citric acid cycle. It oxidises L-malate to oxaloacetate and donates electrons to ubiquinone-1 and other artificial acceptors or, via the electron transfer chain, to oxygen. NAD is not an acceptor and the natural direct acceptor for the enzyme is most likely a quinone; malate dehydrogenase (acceptor) complement(1527042..1528529) Arthrobacter arilaitensis Re117 9795549 YP_003916541.1 CDS AARI_13640 NC_014550.1 1528608 1530452 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein complement(1528608..1530452) Arthrobacter arilaitensis Re117 9794104 YP_003916542.1 CDS AARI_13650 NC_014550.1 1530604 1531536 R match to PF02826 (D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain); D-isomer specific 2-hydroxyacid dehydrogenase family protein complement(1530604..1531536) Arthrobacter arilaitensis Re117 9795550 YP_003916543.1 CDS bcp NC_014550.1 1532431 1532922 D peroxiredoxin protects cells against toxicity from reactive oxygen species by reducing and detoxifying hydroperoxides. The Bcp protein shows substrate selectivity toward fatty acid hydroperoxides rather than hydrogen peroxide or alkyl hydroperoxides; peroxiredoxin 1532431..1532922 Arthrobacter arilaitensis Re117 9793612 YP_003916544.1 CDS AARI_13670 NC_014550.1 1533217 1533777 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 1533217..1533777 Arthrobacter arilaitensis Re117 9793613 YP_003916545.1 CDS AARI_13680 NC_014550.1 1533802 1535265 R identified by match to protein family PF01370: NAD dependent epimerase/dehydratase family. This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; NAD dependent epimerase/dehydratase family protein complement(1533802..1535265) Arthrobacter arilaitensis Re117 9795552 YP_003916546.1 CDS AARI_13690 NC_014550.1 1535262 1536092 R 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1535262..1536092) Arthrobacter arilaitensis Re117 9795553 YP_003916547.1 CDS AARI_13700 NC_014550.1 1536208 1536693 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 1536208..1536693 Arthrobacter arilaitensis Re117 9795554 YP_003916548.1 CDS crtE NC_014550.1 1536700 1537809 D identified by similarity to protein SP:Q9KK76 (Brevibacterium linens). A variety of isoprenoid compounds are synthesized by various organisms. In bacteria this pathway leads to the synthesis of isopentenyl tRNA, isoprenoid quinones, and sugar carrier lipids. Farnesyltranstransferase catalyzes the sequential addition of the three molecules of isopentenyl pyrophosphate onto dimethylallyl pyrophosphate to form geranylgeranyl pyrophosphate; farnesyltranstransferase 1536700..1537809 Arthrobacter arilaitensis Re117 9795555 YP_003916549.1 CDS crtB NC_014550.1 1537815 1538759 D identified by similarity to protein SP:Q93QX6 (Corynebacterium glutamicum), match to protein family PF00494. Phytoene synthase catalyzes the conversion of two molecules of geranylgeranyl diphosphate (GGPP) into phytoene. It is the second step in the biosynthesis of carotenoids from isopentenyl diphosphate. It is found in all organisms that synthesize carotenoids: plants and photosynthetic bacteria as well as some non- photosynthetic bacteria and fungi; phytoene synthase 1537815..1538759 Arthrobacter arilaitensis Re117 9793758 YP_003916550.1 CDS crtI NC_014550.1 1538756 1540348 D identified by similarity to protein SP:Q93QX5 (Corynebacterium glutamicum), match to protein family TIGR02734. Involved in carotenoid biosynthesis. Phytoene is converted to lycopene by desaturation at four (two symmetrical pairs of) sites. This is achieved by two enzymes (CrtP and CrtQ) in cyanobacteria (Gloeobacter being an exception) and plants, but by a single enzyme in most other bacteria and in fungi. This single enzyme is called the bacterial-type phytoene desaturase, or CrtI; phytoene desaturase 1538756..1540348 Arthrobacter arilaitensis Re117 9793757 YP_003916551.1 CDS crtYe NC_014550.1 1540345 1540707 D identified by similarity to protein SP:Q93QX4 (Corynebacterium glutamicum). In Corynebacterium glutamicum MJ233C, CrtYe and CrtYf encode the proteins of a C50 carotenoid epsilon cyclase, which is involved in C50 carotenoid biosynthesis. It catalyzes the formation of flavuxanthin from lycopene; C50 carotenoid epsilon cyclase 1540345..1540707 Arthrobacter arilaitensis Re117 9793761 YP_003916552.1 CDS crtYf NC_014550.1 1540697 1541053 D identified by similarity to protein SP:Q93QX3 (Corynebacterium glutamicum). In Corynebacterium glutamicum MJ233C, CrtYe and CrtYf encode the proteins of a C50 carotenoid epsilon cyclase, which is involved in C50 carotenoid biosynthesis. It catalyzes the formation of flavuxanthin from lycopene; C50 carotenoid epsilon cyclase 1540697..1541053 Arthrobacter arilaitensis Re117 9793762 YP_003916553.1 CDS crtEb NC_014550.1 1541050 1541913 D identified by similarity to protein SP:Q93QX2 (Corynebacterium glutamicum). In Corynebacterium glutamicum MJ233C, CrtEb converts lycopene into the acyclic C50 carotenoid flaxuxanthin by the addition of two C5 isoprenoid groups; lycopene elongase 1541050..1541913 Arthrobacter arilaitensis Re117 9793763 YP_003916554.1 CDS idi NC_014550.1 1541940 1542455 D catalyses the interconversion of isopentenyl diphosphate and dimethylallyl diphosphate. Dimethylallyl phosphate is the initial substrate for the biosynthesis of carotenoids and other long chain isoprenoids; isopentenyl-diphosphate delta-isomerase 1541940..1542455 Arthrobacter arilaitensis Re117 9793760 YP_003916555.1 CDS AARI_13780 NC_014550.1 1542616 1543077 R hypothetical protein complement(1542616..1543077) Arthrobacter arilaitensis Re117 9793998 YP_003916556.1 CDS AARI_34900 NC_014550.1 1543246 1544316 D transposase of ISAar1, IS1595 family, ISSod11 group 1543246..1544316 Arthrobacter arilaitensis Re117 9795556 YP_003916557.1 CDS ilvB NC_014550.1 1544871 1546769 D acetolactate synthase catalyses the first common step in the biosynthesis of the 3 branched-chain amino acids. The first step involves the condensation of either pyruvate or 2-ketobutyrate with the two-carbon hydroxyethyl fragment derived from another pyruvate molecule, covalently bound to the coenzyme thiamine diphosphate. The resulting products are 2-acetolactate and 2-aceto2-hydroxybutanoate; acetolactate synthase large subunit 1544871..1546769 Arthrobacter arilaitensis Re117 9793432 YP_003916558.1 CDS ilvN NC_014550.1 1546773 1547291 D acetolactate synthase catalyses the first common step in the biosynthesis of the 3 branched-chain amino acids. The first step involves the condensation of either pyruvate or 2-ketobutyrate with the two-carbon hydroxyethyl fragment derived from another pyruvate molecule, covalently bound to the coenzyme thiamine diphosphate. The resulting products are 2-acetolactate and 2-aceto2-hydroxybutanoate; acetolactate synthase small subunit 1546773..1547291 Arthrobacter arilaitensis Re117 9794003 YP_003916559.1 CDS ilvC NC_014550.1 1547416 1548447 D catalyses the conversion of acetohydroxy acids into dihydroxy valerates. This reaction is the second in the synthetic pathway of the branched chain amino acids leucine, valine and isoleucine; ketol-acid reductoisomerase 1547416..1548447 Arthrobacter arilaitensis Re117 9794007 YP_003916560.1 CDS AARI_13820 NC_014550.1 1548637 1549293 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.464 between position 43 and 44; hypothetical protein complement(1548637..1549293) Arthrobacter arilaitensis Re117 9794004 YP_003916561.1 CDS AARI_13830 NC_014550.1 1549493 1550194 D identified by match to protein domain PF08241; SAM-dependent methyltransferase 1549493..1550194 Arthrobacter arilaitensis Re117 9795557 YP_003916562.1 CDS AARI_13840 NC_014550.1 1550673 1553306 D match to PF00196: Bacterial regulatory proteins, luxR family; DNA binding domain-containing protein 1550673..1553306 Arthrobacter arilaitensis Re117 9795558 YP_003916563.1 CDS AARI_13850 NC_014550.1 1553303 1555969 D match to PF00196: Bacterial regulatory proteins, luxR family; DNA binding domain-containing protein 1553303..1555969 Arthrobacter arilaitensis Re117 9795559 YP_003916564.1 CDS AARI_13860 NC_014550.1 1556150 1556389 R hypothetical protein complement(1556150..1556389) Arthrobacter arilaitensis Re117 9795560 YP_003916565.1 CDS AARI_34910 NC_014550.1 1556576 1557883 D transposase of ISAar20, ISL3 family 1556576..1557883 Arthrobacter arilaitensis Re117 9795561 YP_003916566.1 CDS AARI_34930 NC_014550.1 1558628 1559935 R transposase of ISAar19, ISL3 family complement(1558628..1559935) Arthrobacter arilaitensis Re117 9793434 YP_003916567.1 CDS AARI_13870 NC_014550.1 1561047 1562405 D sugar transferase 1561047..1562405 Arthrobacter arilaitensis Re117 9793436 YP_003916568.1 CDS AARI_13880 NC_014550.1 1562949 1564556 D match to PF02018; carbohydrate binding domain-containing protein 1562949..1564556 Arthrobacter arilaitensis Re117 9795562 YP_003916569.1 CDS AARI_13890 NC_014550.1 1564632 1565600 R hypothetical protein complement(1564632..1565600) Arthrobacter arilaitensis Re117 9795563 YP_003916570.1 CDS AARI_13900 NC_014550.1 1565593 1566123 R match to PF00132: Bacterial transferase hexapeptide repeat. A number of different transferase protein families contain this repeat, such as galactoside acetyltransferase- like proteins, the gamma-class of carbonic anhydrases, and tetrahydrodipicolinate-N-succinlytransferases; transferase complement(1565593..1566123) Arthrobacter arilaitensis Re117 9795564 YP_003916571.1 CDS AARI_13910 NC_014550.1 1566120 1567619 R match to protein family PF02706. This family includes proteins involved in lipopolysaccharide (lps) biosynthesis; lipopolysaccharide biosynthesis protein complement(1566120..1567619) Arthrobacter arilaitensis Re117 9795565 YP_003916572.1 CDS AARI_13920 NC_014550.1 1567733 1568680 R match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 complement(1567733..1568680) Arthrobacter arilaitensis Re117 9795566 YP_003916573.1 CDS AARI_13930 NC_014550.1 1568822 1570147 D 10 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1568822..1570147 Arthrobacter arilaitensis Re117 9795567 YP_003916574.1 CDS AARI_13940 NC_014550.1 1570218 1570901 R hypothetical protein complement(1570218..1570901) Arthrobacter arilaitensis Re117 9795568 YP_003916575.1 CDS AARI_13950 NC_014550.1 1571099 1572655 D 14 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1571099..1572655 Arthrobacter arilaitensis Re117 9795569 YP_003916576.1 CDS AARI_13960 NC_014550.1 1572683 1573582 D identified by match to PF00686. This family includes a range of sulphotransferase proteins including flavonyl 3-sulphotransferase, aryl sulphotransferase, alcohol sulphotransferase, estrogen sulphotransferase and phenol-sulphating phenol sulphotransferase. These enzymes are responsible for the transfer of sulphate groups to specific compounds; sulfotransferase domain-containig protein 1572683..1573582 Arthrobacter arilaitensis Re117 9795570 YP_003916577.1 CDS AARI_13970 NC_014550.1 1573661 1574947 D hypothetical protein 1573661..1574947 Arthrobacter arilaitensis Re117 9795571 YP_003916578.1 CDS AARI_13980 NC_014550.1 1575228 1579541 D match to protein domain PF00801; PDK domain-containing protein 1575228..1579541 Arthrobacter arilaitensis Re117 9795572 YP_003916579.1 CDS AARI_13990 NC_014550.1 1579672 1581435 D divalent anion:Na+ symporter (DASS) family (TC 2.A. 47.y.z). Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate; DASS family symporter 1579672..1581435 Arthrobacter arilaitensis Re117 9795573 YP_003916580.1 CDS AARI_34950 NC_014550.1 1581812 1583089 D transposase of ISAar15, ISL3 family 1581812..1583089 Arthrobacter arilaitensis Re117 9795574 YP_003916581.1 CDS cysC NC_014550.1 1583191 1584342 R identified by match to PF01583. Ultimate step in biosynthesis of 3-phosphoadenosine 5-phosphosulfate (PAPS), the primary biological sulfuryl donor; adenylyl-sulfate kinase complement(1583191..1584342) Arthrobacter arilaitensis Re117 9793437 YP_003916582.1 CDS cysQ NC_014550.1 1584535 1585293 D identified by similarity to protein SP:P65163 (Mycobacterium tuberculosis). This enzyme (PAPS 3- phosphatase) is considered as an important regulator of the sulfate assimilation pathway, by controlling the pools of PAP and PAPS; 3'-phosphoadenosine-5'-phosphosulfate 3'-phosphatase 1584535..1585293 Arthrobacter arilaitensis Re117 9793775 YP_003916583.1 CDS cysD NC_014550.1 1585327 1586250 D catalyses the formation of diphosphate and adenylyl sulphate from ATP and sulphate. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism; sulfate adenylyltransferase small subunit 1585327..1586250 Arthrobacter arilaitensis Re117 9793783 YP_003916584.1 CDS cysN NC_014550.1 1586252 1587502 D catalyses the formation of diphosphate and adenylyl sulphate from ATP and sulphate. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism; sulfate adenylyltransferase large subunit 1586252..1587502 Arthrobacter arilaitensis Re117 9793776 YP_003916585.1 CDS AARI_14040 NC_014550.1 1587797 1588249 D match to protein family PF08660. Possibly involved in the biosynthesis of an exopolysaccharide; oligosaccharide biosynthesis Alg14-like protein 1587797..1588249 Arthrobacter arilaitensis Re117 9793781 YP_003916586.1 CDS AARI_14050 NC_014550.1 1588246 1588827 D match to PF04101: Glycosyltransferase family 28 C- terminal domain. This family family comprises enzymes with a number of known activities; 1,2-diacylglycerol 3-beta- galactosyltransferase (EC 2.4.1.46); 1,2-diacylglycerol 3- beta-glucosyltransferase (EC 2.4.1.157); beta-N- acetylglucosamine transferase (EC 2.4.1); glycosyl transferase family 28 1588246..1588827 Arthrobacter arilaitensis Re117 9795575 YP_003916587.1 CDS serA NC_014550.1 1589185 1590780 D catalyzes the oxidation of D-3-phosphoglycerate to 3- phosphohydroxypyruvate, which is the first step in the biosynthesis of L-serine, using NAD+ as the oxidizing agent; phosphoglycerate dehydrogenase 1589185..1590780 Arthrobacter arilaitensis Re117 9795576 YP_003916588.1 CDS AARI_14070 NC_014550.1 1591216 1591329 R hypothetical protein complement(1591216..1591329) Arthrobacter arilaitensis Re117 9794392 YP_003916589.1 CDS AARI_14080 NC_014550.1 1591807 1593528 D hypothetical protein 1591807..1593528 Arthrobacter arilaitensis Re117 9795577 YP_003916590.1 CDS AARI_14090 NC_014550.1 1593811 1594026 D hypothetical protein 1593811..1594026 Arthrobacter arilaitensis Re117 9795578 YP_003916591.1 CDS AARI_34960 NC_014550.1 1594299 1595744 R transposase of ISAar27, IS481 family complement(1594299..1595744) Arthrobacter arilaitensis Re117 9795579 YP_003916592.1 CDS AARI_34970 NC_014550.1 1596324 1597601 D transposase of ISAar13, ISL3 family 1596324..1597601 Arthrobacter arilaitensis Re117 9795580 YP_003916593.1 CDS AARI_14110 NC_014550.1 1597733 1598140 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1597733..1598140 Arthrobacter arilaitensis Re117 9793439 YP_003916594.1 CDS AARI_14120 NC_014550.1 1598204 1600015 D hypothetical protein 1598204..1600015 Arthrobacter arilaitensis Re117 9795581 YP_003916595.1 CDS AARI_14130 NC_014550.1 1600018 1600593 D hypothetical protein 1600018..1600593 Arthrobacter arilaitensis Re117 9795582 YP_003916596.1 CDS AARI_14140 NC_014550.1 1600590 1605581 D match to PF00535 and PF00534; hypothetical protein 1600590..1605581 Arthrobacter arilaitensis Re117 9795583 YP_003916597.1 CDS AARI_14150 NC_014550.1 1605868 1607610 D match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 1605868..1607610 Arthrobacter arilaitensis Re117 9795584 YP_003916598.1 CDS AARI_14160 NC_014550.1 1607661 1608836 D match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 1607661..1608836 Arthrobacter arilaitensis Re117 9795585 YP_003916599.1 CDS AARI_14170 NC_014550.1 1608847 1610592 D match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 1608847..1610592 Arthrobacter arilaitensis Re117 9795586 YP_003916600.1 CDS wecC NC_014550.1 1610724 1611956 D catalyzes the oxidation of UDP-N-acetyl-D- mannosamine to UDP-N-acetyl-D-mannosaminuronic acid. In Escherichia coli, UDP-N-acetyl-D-glucosamine 2-epimerase and UDP-N-acetyl-D-mannosamine dehydrogenase are responsible for the formation of UDP-N-acetyl-D- mannosaminuronic acid from UDP-N-acetyl-D-glucosamine; UDP-N-acetyl-D-mannosamine dehydrogenase 1610724..1611956 Arthrobacter arilaitensis Re117 9795587 YP_003916601.1 CDS wecB NC_014550.1 1611983 1613167 D catalyses the formation of UDP-N-acetyl-D- mannosamine from UDP-N-acetyl-D-glucosamine. The enzyme also hydrolyses the product to UDP and N-acetyl-D- mannosamine. In Escherichia coli, UDP-N-acetyl-D- glucosamine 2-epimerase and UDP-N-acetyl-D-mannosamine dehydrogenase are responsible for the formation of UDP-N- acetyl-D-mannosaminuronic acid from UDP-N-acetyl-D- glucosamine; UDP-N-acetylglucosamine 2-epimerase 1611983..1613167 Arthrobacter arilaitensis Re117 9794503 YP_003916602.1 CDS AARI_14200 NC_014550.1 1613291 1614298 D hypothetical protein 1613291..1614298 Arthrobacter arilaitensis Re117 9794502 YP_003916603.1 CDS metG NC_014550.1 1614356 1615906 D activates methionine and transfers it to tRNA(Met) as the first step in protein biosynthesis; methionine--tRNA ligase 1614356..1615906 Arthrobacter arilaitensis Re117 9795588 YP_003916604.1 CDS AARI_14220 NC_014550.1 1615976 1616668 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(1615976..1616668) Arthrobacter arilaitensis Re117 9794071 YP_003916605.1 CDS AARI_14230 NC_014550.1 1616675 1617907 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(1616675..1617907) Arthrobacter arilaitensis Re117 9795589 YP_003916606.1 CDS leuB NC_014550.1 1618090 1619148 D involved in leucine biosynthesis. Catalyzes the oxidative decarboxylation of 3-isopropylmalate into 2-oxo- 4-methylvalerate; 3-isopropylmalate dehydrogenase 1618090..1619148 Arthrobacter arilaitensis Re117 9795590 YP_003916607.1 CDS ilvE NC_014550.1 1619263 1620357 D last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine; branched-chain-amino-acid transaminase 1619263..1620357 Arthrobacter arilaitensis Re117 9794032 YP_003916608.1 CDS galE NC_014550.1 1620432 1621463 D catalyses the formation of UDP-glucose from UDP- galactose. Involved in the catabolism of galactose; UDP-glucose 4-epimerase 1620432..1621463 Arthrobacter arilaitensis Re117 9794006 YP_003916609.1 CDS AARI_14270 NC_014550.1 1621743 1623059 D hypothetical protein 1621743..1623059 Arthrobacter arilaitensis Re117 9793879 YP_003916610.1 CDS AARI_34980 NC_014550.1 1623124 1624401 D transposase of ISAar13, ISL3 family 1623124..1624401 Arthrobacter arilaitensis Re117 9795591 YP_003916611.1 CDS AARI_14280 NC_014550.1 1624604 1624744 D hypothetical protein 1624604..1624744 Arthrobacter arilaitensis Re117 9793440 YP_003916612.1 CDS AARI_34990 NC_014550.1 1624848 1626155 D transposase of ISAar19, ISL3 family 1624848..1626155 Arthrobacter arilaitensis Re117 9795592 YP_003916613.1 CDS AARI_14290 NC_014550.1 1626714 1627478 D fumarylacetoacetate hydrolase family protein 1626714..1627478 Arthrobacter arilaitensis Re117 9793441 YP_003916614.1 CDS gltX NC_014550.1 1627581 1629086 D glutamate--tRNA ligase 1627581..1629086 Arthrobacter arilaitensis Re117 9795593 YP_003916615.1 CDS AARI_14310 NC_014550.1 1630068 1631834 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 1630068..1631834 Arthrobacter arilaitensis Re117 9793615 YP_003916616.1 CDS AARI_14320 NC_014550.1 1631834 1633477 D identified by match to protein family PF01926; GTPase 1631834..1633477 Arthrobacter arilaitensis Re117 9795594 YP_003916617.1 CDS thiL NC_014550.1 1633484 1634500 D catalyses the following reaction: ATP + thiamine phosphate <=> ADP + thiamine diphosphate; thiamine-phosphate kinase 1633484..1634500 Arthrobacter arilaitensis Re117 9795595 YP_003916618.1 CDS AARI_14340 NC_014550.1 1634528 1635253 R identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator complement(1634528..1635253) Arthrobacter arilaitensis Re117 9794444 YP_003916619.1 CDS leuC NC_014550.1 1635367 1636815 D catalyzes the isomerization between (2R,3S)-3- isopropylmalate and (2S)-2-isopropylmalate, via the formation of (2S)-2-isopropylmaleate. Involved in leucine biosynthesis; 3-isopropylmalate dehydratase large subunit 1635367..1636815 Arthrobacter arilaitensis Re117 9795596 YP_003916620.1 CDS leuD NC_014550.1 1636830 1637435 D catalyzes the isomerization between (2R,3S)-3- isopropylmalate and (2S)-2-isopropylmalate, via the formation of (2S)-2-isopropylmaleate. Involved in leucine biosynthesis; 3-isopropylmalate dehydratase small subunit 1636830..1637435 Arthrobacter arilaitensis Re117 9794033 YP_003916621.1 CDS murA NC_014550.1 1637693 1639012 D catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1637693..1639012 Arthrobacter arilaitensis Re117 9794034 YP_003916622.1 CDS AARI_14380 NC_014550.1 1639030 1639794 D 1-acylglycerol-3-phosphate O-acyltransferase catalyzes the following reaction: Acyl-CoA + 1-acyl-sn- glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3- phosphate. It is involved in phospholipid biosynthesis; 1-acylglycerol-3-phosphate O-acyltransferase 1639030..1639794 Arthrobacter arilaitensis Re117 9794116 YP_003916623.1 CDS gpsA NC_014550.1 1639861 1640862 D catalyzes the following reaction: sn-glycerol 3- phosphate + NAD(P)(+) <=> glycerone phosphate + NAD(P)H. Involved in glycerophospholipid metabolism; glycerol-3-phosphate dehydrogenase 1639861..1640862 Arthrobacter arilaitensis Re117 9795597 YP_003916624.1 CDS ddl NC_014550.1 1640862 1641974 D participates in forming UDP-N-acetylmuramyl pentapeptide, the peptidoglycan precursor; D-alanine--D-alanine ligase 1640862..1641974 Arthrobacter arilaitensis Re117 9793934 YP_003916625.1 CDS AARI_14410 NC_014550.1 1642049 1642498 R hypothetical protein complement(1642049..1642498) Arthrobacter arilaitensis Re117 9793798 YP_003916626.1 CDS AARI_14420 NC_014550.1 1642640 1643686 D cell envelope-related transcriptional attenuator 1642640..1643686 Arthrobacter arilaitensis Re117 9795598 YP_003916627.1 CDS AARI_14430 NC_014550.1 1643710 1644678 D match to PF2734 (DAK2; predicted phosphatase domain of the dihydroxyacetone kinase family) domain; DAK2 phosphatase domain-containing protein 1643710..1644678 Arthrobacter arilaitensis Re117 9795599 YP_003916628.1 CDS recG NC_014550.1 1644671 1646860 D RecG protein is a junction-specific DNA helicase that drives branch migration of Holliday intermediates in genetic recombination and DNA repair; ATP-dependent DNA helicase RecG 1644671..1646860 Arthrobacter arilaitensis Re117 9795600 YP_003916629.1 CDS AARI_14450 NC_014550.1 1646880 1647464 D match to PS00092 pattern: N-6 Adenine-specific DNA methylases signature. In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes; adenine-specific DNA-methyltransferase 1646880..1647464 Arthrobacter arilaitensis Re117 9794288 YP_003916630.1 CDS AARI_14460 NC_014550.1 1647441 1648223 R hypothetical protein complement(1647441..1648223) Arthrobacter arilaitensis Re117 9795601 YP_003916631.1 CDS AARI_14470 NC_014550.1 1648220 1649431 R identified by match to PF00155: aminotransferase class I and II; aminotransferase complement(1648220..1649431) Arthrobacter arilaitensis Re117 9795602 YP_003916632.1 CDS coaD NC_014550.1 1649544 1650011 D reversibly transfers an adenylyl group from ATP to 4-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate: ATP + pantetheine 4-phosphate = diphosphate + 3-dephospho-CoA; pantetheine-phosphate adenylyltransferase 1649544..1650011 Arthrobacter arilaitensis Re117 9795603 YP_003916633.1 CDS galU NC_014550.1 1650104 1651003 D catalyses the formation of UDP-glucose from glucose- 1-phosphate; UTP--glucose-1-phosphate uridylyltransferase 1650104..1651003 Arthrobacter arilaitensis Re117 9793749 YP_003916634.1 CDS AARI_14500 NC_014550.1 1651120 1652187 D cell envelope-related transcriptional attenuator 1651120..1652187 Arthrobacter arilaitensis Re117 9793883 YP_003916635.1 CDS AARI_14510 NC_014550.1 1652324 1653172 D TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM), CLS-family (capsular polysaccharide, lipopolysaccharide and teichoic acids). A typical system is made of a conserved permease (IM) and an ATP-binding subunit (ABC). In addition to these proteins, capsular polysaccharide exporter systems require two accessory proteins to perform their function: a periplasmic or a lipid-anchored outer membrane protein called OMA and a cytoplasmic membrane protein MPA2; capsular polysaccharide/lipopolysaccharide/teichoic acids ABC transporter inner membrane subunit 1652324..1653172 Arthrobacter arilaitensis Re117 9795604 YP_003916636.1 CDS AARI_14520 NC_014550.1 1653183 1654049 D TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC), CLS-family (capsular polysaccharide, lipopolysaccharide and teichoic acids). A typical system is made of a conserved permease (IM) and an ATP-binding subunit (ABC). In addition to these proteins, capsular polysaccharide exporter systems require two accessory proteins to perform their function: a periplasmic or a lipid-anchored outer membrane protein called OMA and a cytoplasmic membrane protein MPA2; capsular polysaccharide/lipopolysaccharide/teichoic acids ABC transporter ATP-binding subunit 1653183..1654049 Arthrobacter arilaitensis Re117 9795605 YP_003916637.1 CDS AARI_14530 NC_014550.1 1654057 1655100 D match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 1654057..1655100 Arthrobacter arilaitensis Re117 9795606 YP_003916638.1 CDS AARI_14540 NC_014550.1 1655097 1655915 D match to protein family PF01066. Possibly involved in phospholipid biosynthesis; transferase 1655097..1655915 Arthrobacter arilaitensis Re117 9795607 YP_003916639.1 CDS AARI_14550 NC_014550.1 1655955 1656845 D match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 1655955..1656845 Arthrobacter arilaitensis Re117 9795608 YP_003916640.1 CDS tagD NC_014550.1 1656910 1657371 D involved in teichoic acid biosynthesis; glycerol-3-phosphate cytidylyltransferase 1656910..1657371 Arthrobacter arilaitensis Re117 9795609 YP_003916641.1 CDS AARI_14570 NC_014550.1 1657421 1658794 D hypothetical protein 1657421..1658794 Arthrobacter arilaitensis Re117 9794422 YP_003916642.1 CDS AARI_35010 NC_014550.1 1661432 1662373 R transposase of ISAar44, IS3 family, IS3 group, orfB complement(1661432..1662373) Arthrobacter arilaitensis Re117 9793442 YP_003916643.1 CDS AARI_35020 NC_014550.1 1662472 1662909 R transposase of ISAar44, IS3 family, IS3 group, orfA complement(1662472..1662909) Arthrobacter arilaitensis Re117 9793443 YP_003916644.1 CDS AARI_35030 NC_014550.1 1663196 1664188 R transposase of ISAar46, IS3 family, IS3 group, orfB complement(1663196..1664188) Arthrobacter arilaitensis Re117 9793444 YP_003916645.1 CDS AARI_35040 NC_014550.1 1664185 1664577 R transposase of ISAar46, IS3 family, IS3 group, orfA complement(1664185..1664577) Arthrobacter arilaitensis Re117 9793445 YP_003916646.1 CDS AARI_35050 NC_014550.1 1667982 1668260 D transposase of ISAar3, IS3 family, IS407 group, orfA 1667982..1668260 Arthrobacter arilaitensis Re117 9795612 YP_003916647.1 CDS AARI_35080 NC_014550.1 1669332 1670273 R transposase of ISAar44, IS3 family, IS3 group, orfB complement(1669332..1670273) Arthrobacter arilaitensis Re117 9793449 YP_003916648.1 CDS AARI_35090 NC_014550.1 1670372 1670809 R transposase of ISAar44, IS3 family, IS3 group, orfA complement(1670372..1670809) Arthrobacter arilaitensis Re117 9793450 YP_003916649.1 CDS AARI_35110 NC_014550.1 1670954 1671244 R transposase of ISAar46, IS3 family, IS3 group, orfA complement(1670954..1671244) Arthrobacter arilaitensis Re117 9793452 YP_003916650.1 CDS AARI_14600 NC_014550.1 1672311 1673984 D hypothetical protein 1672311..1673984 Arthrobacter arilaitensis Re117 9793454 YP_003916651.1 CDS AARI_14610 NC_014550.1 1674378 1674899 D hypothetical protein 1674378..1674899 Arthrobacter arilaitensis Re117 9795613 YP_003916652.1 CDS rpmF NC_014550.1 1674902 1675105 D ribosomal protein L32 is part of the 50S ribosomal subunit; 50S ribosomal protein L32 1674902..1675105 Arthrobacter arilaitensis Re117 9795614 YP_003916653.1 CDS rnc NC_014550.1 1675130 1675807 D digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs; ribonuclease III 1675130..1675807 Arthrobacter arilaitensis Re117 9794338 YP_003916654.1 CDS mutM NC_014550.1 1675819 1676742 D formamidopyrimidine-DNA glycosylases is a trifunctional DNA base excision repair enzyme that removes a wide range of oxidation-damaged bases (N-glycosylase activity; EC:3.2.2.23) and cleaves both the 3- and 5- phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity; EC:4.2.99. 18). It has a preference for oxidised purines, excising oxidized purine bases such as 7,8-dihydro-8- oxoguanine (8-oxoG). Its AP (apurinic/apyrimidinic) lyase activity introduces nicks in the DNA strand, cleaving the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3- and 5-phosphates; formamidopyrimidine-DNA glycosylase 1675819..1676742 Arthrobacter arilaitensis Re117 9794304 YP_003916655.1 CDS AARI_14650 NC_014550.1 1676944 1677756 R match to protein family PF00144: beta-lactamase; hypothetical protein complement(1676944..1677756) Arthrobacter arilaitensis Re117 9794124 YP_003916656.1 CDS smc NC_014550.1 1677906 1681478 D identified by match to protein family TIGR02168. Smc participates in chromosomal partition during cell division. Component of a cohesin-like complex composed of scpA, scpB and smc; chromosome segregation protein Smc 1677906..1681478 Arthrobacter arilaitensis Re117 9795615 YP_003916657.1 CDS AARI_14670 NC_014550.1 1681553 1682734 R drug:H+ antiporter-1 (12 Spanner) (DHA1) family transporter (TC 2.A.1.2.z). Match to PR01035 (Tetracycline resistance protein signature); multidrug efflux permease complement(1681553..1682734) Arthrobacter arilaitensis Re117 9794397 YP_003916658.1 CDS ftsY NC_014550.1 1682962 1684143 D identified by match to protein family TIGR00064. FtsY is a functional homolog of SRP receptor. Integral membrane proteins, are specifically recognized by a direct interaction between their noncleaved signal anchor sequences and the bacterial signal recognition particle (SRP) consisting of Ffh and 4.5S RNA. Recognition occurs during synthesis at the ribosome and leads to a cotranslational targeting to SecYE that is mediated by FtsY and the hydrolysis of GTP; signal recognition particle-docking protein FtsY 1682962..1684143 Arthrobacter arilaitensis Re117 9795616 YP_003916659.1 CDS AARI_14690 NC_014550.1 1684605 1685252 R 3-methyladenine DNA glycosylase is a base excision- repair protein. It is responsible for the hydrolysis of the deoxyribose N-glycosidic bond, excising 3- methyladenine from damaged DNA; 3-methyladenine DNA glycosylase complement(1684605..1685252) Arthrobacter arilaitensis Re117 9793870 YP_003916660.1 CDS amt NC_014550.1 1685591 1686811 D involved in the uptake of ammonia. Ammonia channel transporter (Amt) family (TC 1.A.11.y.z). The generalized transport reactions catalyzed by members of the Amt family are suggested to be: NH4+ (out) <--> NH4+ (in); ammonia transporter 1685591..1686811 Arthrobacter arilaitensis Re117 9795617 YP_003916661.1 CDS AARI_14710 NC_014550.1 1687046 1689148 D decomposes hydrogen peroxide to molecular oxygen and water. Its main function is to protect cells from the toxic effects of hydrogen peroxide; catalase 1687046..1689148 Arthrobacter arilaitensis Re117 9793665 YP_003916662.1 CDS AARI_14720 NC_014550.1 1689246 1690376 D identified by match to PF03631 (ribonuclease_BN, ribonuclease BN-like family): this family contains integral membrane proteins with 5 to 6 predicted transmembrane spans. The family includes ribonuclease BN, which is involved in tRNA maturation; ribonuclease BN-like protein 1689246..1690376 Arthrobacter arilaitensis Re117 9795618 YP_003916663.1 CDS AARI_14730 NC_014550.1 1690479 1690955 D identified by match to PF01243: pyridoxamine 5- phosphate oxidase. This entry represents the FMN-binding domain present in pyridoxamine 5-phosphate oxidases, as well as in a number of proteins that have not been demonstrated to have enzymatic activity; FMN binding domain-containing protein 1690479..1690955 Arthrobacter arilaitensis Re117 9795619 YP_003916664.1 CDS AARI_14740 NC_014550.1 1691084 1691275 R identified by match to protein family PF05532. CsbD is a bacterial general stress response protein. Its expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear; CsbD family protein complement(1691084..1691275) Arthrobacter arilaitensis Re117 9795620 YP_003916665.1 CDS AARI_14750 NC_014550.1 1691507 1693216 R major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z). Identified by match to protein family TIGR00711; EmrB/QacA subfamily drug resistance transporter complement(1691507..1693216) Arthrobacter arilaitensis Re117 9795621 YP_003916666.1 CDS AARI_14760 NC_014550.1 1693254 1693919 R transcriptional regulator complement(1693254..1693919) Arthrobacter arilaitensis Re117 9795622 YP_003916667.1 CDS AARI_14770 NC_014550.1 1694274 1695335 D hypothetical protein 1694274..1695335 Arthrobacter arilaitensis Re117 9795623 YP_003916668.1 CDS AARI_14780 NC_014550.1 1695332 1696699 D match to protein family PF02585 and PF05401. Possibly involved in polysaccharide synthesis; hypothetical protein 1695332..1696699 Arthrobacter arilaitensis Re117 9795624 YP_003916669.1 CDS AARI_14790 NC_014550.1 1696692 1697426 D match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 1696692..1697426 Arthrobacter arilaitensis Re117 9795625 YP_003916670.1 CDS AARI_14800 NC_014550.1 1697535 1697978 R hypothetical protein complement(1697535..1697978) Arthrobacter arilaitensis Re117 9795626 YP_003916671.1 CDS AARI_14810 NC_014550.1 1698304 1699731 R hypothetical protein complement(1698304..1699731) Arthrobacter arilaitensis Re117 9795627 YP_003916672.1 CDS AARI_14820 NC_014550.1 1699728 1700258 R hypothetical protein complement(1699728..1700258) Arthrobacter arilaitensis Re117 9795628 YP_003916673.1 CDS AARI_14830 NC_014550.1 1700454 1701179 R hypothetical protein complement(1700454..1701179) Arthrobacter arilaitensis Re117 9795629 YP_003916674.1 CDS ffh NC_014550.1 1701450 1703015 D identified by match to protein family TIGR00959. Integral membrane proteins, are specifically recognized by a direct interaction between their noncleaved signal anchor sequences and the bacterial signal recognition particle (SRP) consisting of Ffh and 4.5S RNA. Recognition occurs during synthesis at the ribosome and leads to a cotranslational targeting to SecYE that is mediated by FtsY and the hydrolysis of GTP; signal recognition particle protein Ffh 1701450..1703015 Arthrobacter arilaitensis Re117 9795630 YP_003916675.1 CDS AARI_14850 NC_014550.1 1703369 1703851 R hypothetical protein complement(1703369..1703851) Arthrobacter arilaitensis Re117 9793848 YP_003916676.1 CDS AARI_14860 NC_014550.1 1703983 1704432 R hypothetical protein complement(1703983..1704432) Arthrobacter arilaitensis Re117 9795631 YP_003916677.1 CDS AARI_14870 NC_014550.1 1704604 1705167 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 1704604..1705167 Arthrobacter arilaitensis Re117 9795632 YP_003916678.1 CDS AARI_14880 NC_014550.1 1705394 1705669 D hypothetical protein 1705394..1705669 Arthrobacter arilaitensis Re117 9795633 YP_003916679.1 CDS AARI_14890 NC_014550.1 1706002 1707195 D match to the inorganic pyrophosphatase (PS00387) and Trp-Asp (WD) repeats (PS00678) signatures; hypothetical protein 1706002..1707195 Arthrobacter arilaitensis Re117 9795634 YP_003916680.1 CDS AARI_35130 NC_014550.1 1707340 1708539 D transposase of ISAar21, IS4 family, IS4 group 1707340..1708539 Arthrobacter arilaitensis Re117 9795635 YP_003916681.1 CDS AARI_35140 NC_014550.1 1709202 1710509 R transposase of ISAar19, ISL3 family complement(1709202..1710509) Arthrobacter arilaitensis Re117 9793455 YP_003916682.1 CDS AARI_14900 NC_014550.1 1710732 1712102 D match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 1710732..1712102 Arthrobacter arilaitensis Re117 9793456 YP_003916683.1 CDS AARI_35150 NC_014550.1 1712722 1714029 D transposase of ISAar23, ISL3 family 1712722..1714029 Arthrobacter arilaitensis Re117 9795636 YP_003916684.1 CDS AARI_14910 NC_014550.1 1715295 1715405 D hypothetical protein 1715295..1715405 Arthrobacter arilaitensis Re117 9793459 YP_003916685.1 CDS AARI_35180 NC_014550.1 1715572 1716849 D transposase of ISAar14, ISL3 family 1715572..1716849 Arthrobacter arilaitensis Re117 9795637 YP_003916686.1 CDS AARI_35210 NC_014550.1 1718677 1719876 D transposase of ISAar21, IS4 family, IS4 group 1718677..1719876 Arthrobacter arilaitensis Re117 9793462 YP_003916687.1 CDS AARI_14920 NC_014550.1 1720034 1721746 R match to protein family PF00501. This family of enzymes includes luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely- related synthetases; fatty-acid--Co-A ligase complement(1720034..1721746) Arthrobacter arilaitensis Re117 9793463 YP_003916688.1 CDS AARI_14930 NC_014550.1 1721984 1723690 R match to protein family PF00501. This family of enzymes includes luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely- related synthetases; fatty-acid--Co-A ligase complement(1721984..1723690) Arthrobacter arilaitensis Re117 9795638 YP_003916689.1 CDS AARI_14940 NC_014550.1 1723893 1724960 R thermonuclease catalyzes the hydrolysis of both DNA and RNA at the 5-position of the phosphodiester; thermonuclease complement(1723893..1724960) Arthrobacter arilaitensis Re117 9795639 YP_003916690.1 CDS AARI_14950 NC_014550.1 1725216 1726274 R thermonuclease catalyzes the hydrolysis of both DNA and RNA at the 5-position of the phosphodiester; thermonuclease complement(1725216..1726274) Arthrobacter arilaitensis Re117 9795640 YP_003916691.1 CDS AARI_14960 NC_014550.1 1726482 1727351 D ring-cleavage extradiol dioxygenase 1726482..1727351 Arthrobacter arilaitensis Re117 9795641 YP_003916692.1 CDS AARI_14970 NC_014550.1 1727459 1728232 R match to PF00132: Bacterial transferase hexapeptide repeat. A number of different transferase protein families contain this repeat, such as galactoside acetyltransferase- like proteins, the gamma-class of carbonic anhydrases, and tetrahydrodipicolinate-N-succinlytransferases; transferase complement(1727459..1728232) Arthrobacter arilaitensis Re117 9795642 YP_003916693.1 CDS AARI_14980 NC_014550.1 1728312 1730120 R match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 complement(1728312..1730120) Arthrobacter arilaitensis Re117 9795643 YP_003916694.1 CDS AARI_15010 NC_014550.1 1730973 1731101 D hypothetical protein 1730973..1731101 Arthrobacter arilaitensis Re117 9795646 YP_003916695.1 CDS AARI_15020 NC_014550.1 1731224 1732234 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(1731224..1732234) Arthrobacter arilaitensis Re117 9795647 YP_003916696.1 CDS AARI_15030 NC_014550.1 1732446 1733435 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit 1732446..1733435 Arthrobacter arilaitensis Re117 9795648 YP_003916697.1 CDS AARI_15040 NC_014550.1 1733432 1734487 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit 1733432..1734487 Arthrobacter arilaitensis Re117 9795649 YP_003916698.1 CDS AARI_15050 NC_014550.1 1734552 1736279 D identified by match to PF01844; HNH endonuclease domain-containing protein 1734552..1736279 Arthrobacter arilaitensis Re117 9795650 YP_003916699.1 CDS AARI_15060 NC_014550.1 1736325 1736954 R resistance to homoSer/Thr (RhtB) family protein (TC 2.A.76.y.z). The family includes homoserine, threonine and leucine efflux proteins. The transport reaction presumably catalyzed by members of the RhtB family is: amino acid (in) + nH+ (out) <--> amino acid (out) + nH+ (in); RHBT family amino acid transporter complement(1736325..1736954) Arthrobacter arilaitensis Re117 9795651 YP_003916700.1 CDS rpsP NC_014550.1 1737205 1737615 D 30S ribosomal protein S16 1737205..1737615 Arthrobacter arilaitensis Re117 9795652 YP_003916701.1 CDS AARI_15080 NC_014550.1 1737618 1737860 D hypothetical protein 1737618..1737860 Arthrobacter arilaitensis Re117 9794363 YP_003916702.1 CDS rimM NC_014550.1 1738015 1738557 D essential for efficient processing of 16S rRNA. It is needed in a step prior to rbfA during the maturation of 16S rRNA; 16S rRNA-processing protein RimM 1738015..1738557 Arthrobacter arilaitensis Re117 9795653 YP_003916703.1 CDS trmD NC_014550.1 1738561 1739385 D specifically methylates guanosine-37 in various tRNAs; tRNA (guanine-N(1)-)-methyltransferase 1738561..1739385 Arthrobacter arilaitensis Re117 9794301 YP_003916704.1 CDS rplS NC_014550.1 1739636 1739995 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1739636..1739995 Arthrobacter arilaitensis Re117 9794465 YP_003916705.1 CDS lepB NC_014550.1 1740009 1740656 D signal peptidases remove the signal peptides from secretory proteins. In prokaryotes three types of signal peptidases are known: type I (gene lepB) which is responsible for the processing of the majority of exported pre-proteins; type II (gene lsp) which only process lipoproteins, and a third type involved in the processing of pili subunits; signal peptidase I 1740009..1740656 Arthrobacter arilaitensis Re117 9794326 YP_003916706.1 CDS AARI_15130 NC_014550.1 1741080 1743521 D hypothetical protein 1741080..1743521 Arthrobacter arilaitensis Re117 9794030 YP_003916707.1 CDS AARI_15140 NC_014550.1 1743695 1744282 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.703 between position 44 and 45; hypothetical protein 1743695..1744282 Arthrobacter arilaitensis Re117 9795654 YP_003916708.1 CDS AARI_15150 NC_014550.1 1744429 1745154 D non-secretory protein prediction by SignalP 3.0 HMM; signal peptidase I-like protein 1744429..1745154 Arthrobacter arilaitensis Re117 9795655 YP_003916709.1 CDS rnhB NC_014550.1 1745166 1745891 D recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes; ribonuclease HII 1745166..1745891 Arthrobacter arilaitensis Re117 9795656 YP_003916710.1 CDS AARI_15170 NC_014550.1 1745891 1746211 D hypothetical protein 1745891..1746211 Arthrobacter arilaitensis Re117 9794305 YP_003916711.1 CDS AARI_15180 NC_014550.1 1746307 1747200 R TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, binding protein (BP), OTCN-family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L-proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter substrate-binding protein complement(1746307..1747200) Arthrobacter arilaitensis Re117 9795657 YP_003916712.1 CDS AARI_15190 NC_014550.1 1747309 1748205 R TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, permease (IM), OTCN- family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L- proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter inner membrane subunit complement(1747309..1748205) Arthrobacter arilaitensis Re117 9795658 YP_003916713.1 CDS AARI_15200 NC_014550.1 1748205 1749473 R TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OTCN-family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L-proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter ATP-binding subunit complement(1748205..1749473) Arthrobacter arilaitensis Re117 9795659 YP_003916714.1 CDS AARI_35220 NC_014550.1 1749948 1751225 R transposase of ISAar13, ISL3 family complement(1749948..1751225) Arthrobacter arilaitensis Re117 9795660 YP_003916715.1 CDS AARI_15210 NC_014550.1 1751494 1751856 D hypothetical protein 1751494..1751856 Arthrobacter arilaitensis Re117 9793464 YP_003916716.1 CDS AARI_15220 NC_014550.1 1751853 1753406 D match to protein family TIGR00368; Mg chelatase-like protein 1751853..1753406 Arthrobacter arilaitensis Re117 9795661 YP_003916717.1 CDS AARI_15230 NC_014550.1 1753415 1754659 D the SMF family (DNA processing chain A, dprA) are a group of bacterial proteins. In Helicobacter pylori, dprA is required for natural chromosomal and plasmid transformation; smf family protein 1753415..1754659 Arthrobacter arilaitensis Re117 9795662 YP_003916718.1 CDS xerC NC_014550.1 1754679 1755683 D site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids; tyrosine recombinase subunit XerC 1754679..1755683 Arthrobacter arilaitensis Re117 9795663 YP_003916719.1 CDS AARI_15250 NC_014550.1 1755826 1756329 D hypothetical protein 1755826..1756329 Arthrobacter arilaitensis Re117 9794507 YP_003916720.1 CDS AARI_15260 NC_014550.1 1756624 1757004 D match to PS00082 extradiol ring-cleavage dioxygenases signature; ring-cleavage extradiol dioxygenase 1756624..1757004 Arthrobacter arilaitensis Re117 9795664 YP_003916721.1 CDS AARI_15270 NC_014550.1 1757007 1757582 R match to protein domain PF01872. This domain is found in the C-terminus of the bifunctional deaminase- reductase in combination with PF00383 as well as in isolation in some archaebacterial proteins; RibD domain-containing protein complement(1757007..1757582) Arthrobacter arilaitensis Re117 9795665 YP_003916722.1 CDS AARI_15280 NC_014550.1 1757774 1759021 R catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP; 3-oxoacyl-ACP synthase 2 complement(1757774..1759021) Arthrobacter arilaitensis Re117 9795666 YP_003916723.1 CDS acpP NC_014550.1 1759142 1759387 R also named fatty acid synthase ACP. Carrier of the growing fatty acid chain in fatty acid biosynthesis; ACP complement(1759142..1759387) Arthrobacter arilaitensis Re117 9795667 YP_003916724.1 CDS fabD NC_014550.1 1759610 1760533 R involved in the initiation of fatty-acid biosynthesis in bacteria; malonyl CoA-ACP transacylase complement(1759610..1760533) Arthrobacter arilaitensis Re117 9793652 YP_003916725.1 CDS AARI_15310 NC_014550.1 1760710 1761921 R hypothetical protein complement(1760710..1761921) Arthrobacter arilaitensis Re117 9793837 YP_003916726.1 CDS aceE NC_014550.1 1762055 1764829 R the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3); pyruvate dehydrogenase E1 component subunit alpha complement(1762055..1764829) Arthrobacter arilaitensis Re117 9795668 YP_003916727.1 CDS AARI_15330 NC_014550.1 1765162 1765578 D hypothetical protein 1765162..1765578 Arthrobacter arilaitensis Re117 9793649 YP_003916728.1 CDS AARI_15340 NC_014550.1 1765578 1766030 D thiol-specific antioxidant proteins confer a protective role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF; thiol-specific antioxidant protein 1765578..1766030 Arthrobacter arilaitensis Re117 9795669 YP_003916729.1 CDS AARI_15350 NC_014550.1 1766464 1766721 R hypothetical protein complement(1766464..1766721) Arthrobacter arilaitensis Re117 9793616 YP_003916730.1 CDS AARI_15360 NC_014550.1 1767101 1767709 D identified by match to protein domain PF08241; SAM-dependent methyltransferase 1767101..1767709 Arthrobacter arilaitensis Re117 9793617 YP_003916731.1 CDS AARI_15370 NC_014550.1 1767969 1768631 D 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1767969..1768631 Arthrobacter arilaitensis Re117 9795672 YP_003916732.1 CDS AARI_15380 NC_014550.1 1768618 1768911 D transcriptional regulator 1768618..1768911 Arthrobacter arilaitensis Re117 9795673 YP_003916733.1 CDS AARI_15390 NC_014550.1 1769073 1769267 D identified by match to protein family PF05532. CsbD is a bacterial general stress response protein. Its expression is mediated by sigma-B, an alternative sigma factor. The role of CsbD in stress response is unclear; CsbD family protein 1769073..1769267 Arthrobacter arilaitensis Re117 9795674 YP_003916734.1 CDS AARI_15400 NC_014550.1 1769354 1770580 R match to protein domain PF05175. This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases; methyltransferase complement(1769354..1770580) Arthrobacter arilaitensis Re117 9795675 YP_003916735.1 CDS AARI_15410 NC_014550.1 1770656 1771879 R match to PF04101: Glycosyltransferase family 28 N- terminal domain. This family family comprises enzymes with a number of known activities; 1,2-diacylglycerol 3-beta- galactosyltransferase (EC 2.4.1.46); 1,2-diacylglycerol 3- beta-glucosyltransferase (EC 2.4.1.157); beta-N- acetylglucosamine transferase (EC 2.4.1); glycosyl transferase family 28 complement(1770656..1771879) Arthrobacter arilaitensis Re117 9795676 YP_003916736.1 CDS AARI_15420 NC_014550.1 1771974 1772615 D match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator 1771974..1772615 Arthrobacter arilaitensis Re117 9795677 YP_003916737.1 CDS argE NC_014550.1 1772732 1773877 D removes the acetyl group from N-acetyl-ornithine. Involved in arginine biosynthesis; acetylornithine deacetylase 1772732..1773877 Arthrobacter arilaitensis Re117 9795678 YP_003916738.1 CDS AARI_15440 NC_014550.1 1773928 1775148 D major facilitator superfamily (MFS), metabolite:H+ symporter (MHS) family (TC 2.A.1.6.z); MFS superfamily transporter 1773928..1775148 Arthrobacter arilaitensis Re117 9793675 YP_003916739.1 CDS AARI_15450 NC_014550.1 1775229 1775918 R identified by match to protein family PF03006: HlyIII, Haemolysin-III related; hemolysin III-like protein complement(1775229..1775918) Arthrobacter arilaitensis Re117 9795679 YP_003916740.1 CDS AARI_15460 NC_014550.1 1776032 1776964 D match to protein family PF06414. This family consists of several bacterial zeta toxin proteins. Zeta toxin is thought to be part of a postregulational killing system in bacteria. It relies on antitoxin/toxin systems that secure stable inheritance of low and medium copy number plasmids during cell division and kill cells that have lost the plasmid; zeta toxin-like protein 1776032..1776964 Arthrobacter arilaitensis Re117 9795680 YP_003916741.1 CDS AARI_15470 NC_014550.1 1777047 1777307 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1777047..1777307) Arthrobacter arilaitensis Re117 9795681 YP_003916742.1 CDS AARI_15480 NC_014550.1 1777627 1778133 D catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product, gluconate-6-phoshate, is an important precursor of gluconate metabolism; gluconokinase 1777627..1778133 Arthrobacter arilaitensis Re117 9795682 YP_003916743.1 CDS gntP NC_014550.1 1778201 1779616 D Gluconate:H+ Symporter (GntP) Family (TC 2.A.8.y.z). Match to protein family PF02447; gluconate permease 1778201..1779616 Arthrobacter arilaitensis Re117 9795683 YP_003916744.1 CDS AARI_15500 NC_014550.1 1779898 1780500 D hypothetical protein 1779898..1780500 Arthrobacter arilaitensis Re117 9793932 YP_003916745.1 CDS AARI_15510 NC_014550.1 1780601 1781335 R match to PF00392: bacterial regulatory proteins, gntR family, and to PF07729: FCD domain; GntR family transcriptional regulator complement(1780601..1781335) Arthrobacter arilaitensis Re117 9795684 YP_003916746.1 CDS gnd NC_014550.1 1781545 1782984 D involved in the pentose phosphate pathway. Catalyzes the oxidative decarboxylation of 6- phosphogluconate into ribulose 5-phosphate; phosphogluconate dehydrogenase 1781545..1782984 Arthrobacter arilaitensis Re117 9795685 YP_003916747.1 CDS AARI_15530 NC_014550.1 1783087 1783611 R hypothetical protein complement(1783087..1783611) Arthrobacter arilaitensis Re117 9793930 YP_003916748.1 CDS AARI_15540 NC_014550.1 1783691 1784281 R transcriptional regulator complement(1783691..1784281) Arthrobacter arilaitensis Re117 9795686 YP_003916749.1 CDS AARI_15550 NC_014550.1 1784374 1784766 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1784374..1784766 Arthrobacter arilaitensis Re117 9795687 YP_003916750.1 CDS AARI_15560 NC_014550.1 1784819 1785829 D NADP-dependent oxidoreductase 1784819..1785829 Arthrobacter arilaitensis Re117 9795688 YP_003916751.1 CDS AARI_15570 NC_014550.1 1785886 1786419 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 1785886..1786419 Arthrobacter arilaitensis Re117 9795689 YP_003916752.1 CDS AARI_15580 NC_014550.1 1786420 1786920 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(1786420..1786920) Arthrobacter arilaitensis Re117 9795690 YP_003916753.1 CDS uvrA NC_014550.1 1786923 1789184 R excinuclease ABC catalyses nucleotide excision repair in a multi-step process; excinuclease ABC subunit A complement(1786923..1789184) Arthrobacter arilaitensis Re117 9795691 YP_003916754.1 CDS AARI_15600 NC_014550.1 1789315 1789866 D match to PS51257: prokaryotic membrane lipoprotein lipid attachment site profile; hypothetical protein 1789315..1789866 Arthrobacter arilaitensis Re117 9794495 YP_003916755.1 CDS AARI_15610 NC_014550.1 1790164 1791444 D Dicarboxylate/Amino Acid:Cation (Na+ or H+) symporter (DAACS) family (TC 2.A.23.y.z). The members of the DAACS family catalyze Na+ and/or H+ symport together with (a) a Krebs cycle dicarboxylate (malate, succinate, or fumarate), (b) a dicarboxylic amino acid (glutamate or aspartate), (c) a small, semipolar, neutral amino acid (Ala, Ser, Cys, Thr), (d) both neutral and acidic amino acids or (e) most zwitterionic and dibasic amino acids; dicarboxylate/amino acid transporter 1790164..1791444 Arthrobacter arilaitensis Re117 9795692 YP_003916756.1 CDS cysE NC_014550.1 1791629 1792213 R catalyses the first step of the synthesis of L- cysteine from L-serine; serine O-acetyltransferase complement(1791629..1792213) Arthrobacter arilaitensis Re117 9795693 YP_003916757.1 CDS cysK NC_014550.1 1792357 1793292 R responsible for the formation of cysteine from O- acetyl-serine and hydrogen sulfide with the concomitant release of acetic acid; cysteine synthase complement(1792357..1793292) Arthrobacter arilaitensis Re117 9793778 YP_003916758.1 CDS msrA NC_014550.1 1793419 1794039 R plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged; peptide-methionine (S)-S-oxide reductase complement(1793419..1794039) Arthrobacter arilaitensis Re117 9793780 YP_003916759.1 CDS AARI_15650 NC_014550.1 1794078 1795031 D hypothetical protein 1794078..1795031 Arthrobacter arilaitensis Re117 9794111 YP_003916760.1 CDS AARI_15660 NC_014550.1 1795044 1795427 D hypothetical protein 1795044..1795427 Arthrobacter arilaitensis Re117 9795694 YP_003916761.1 CDS AARI_15670 NC_014550.1 1795481 1795699 R hypothetical protein complement(1795481..1795699) Arthrobacter arilaitensis Re117 9795695 YP_003916762.1 CDS AARI_15680 NC_014550.1 1795696 1796736 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.987 between position 31 and 32; hypothetical protein complement(1795696..1796736) Arthrobacter arilaitensis Re117 9795696 YP_003916763.1 CDS AARI_15690 NC_014550.1 1796805 1797431 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.697 between position 29 and 30; hypothetical protein complement(1796805..1797431) Arthrobacter arilaitensis Re117 9795697 YP_003916764.1 CDS AARI_15700 NC_014550.1 1797472 1799778 R match to PF00149. The metallophosphoesterase motif is found in a large number of proteins invoved in phosphoryation. These include Ser/Thr phosphatases, DNA polymerase, exonucleases, and other phosphatases; metallophosphoesterase domain-containing protein complement(1797472..1799778) Arthrobacter arilaitensis Re117 9795698 YP_003916765.1 CDS AARI_15710 NC_014550.1 1800122 1800901 R hypothetical protein complement(1800122..1800901) Arthrobacter arilaitensis Re117 9795699 YP_003916766.1 CDS gap NC_014550.1 1801611 1803068 D catalyses the reversible oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3- diphospho-glycerate; glyceraldehyde-3-phosphate dehydrogenase 1801611..1803068 Arthrobacter arilaitensis Re117 9795700 YP_003916767.1 CDS def NC_014550.1 1803888 1804460 R involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides; peptide deformylase complement(1803888..1804460) Arthrobacter arilaitensis Re117 9795704 YP_003916768.1 CDS AARI_15780 NC_014550.1 1804485 1805633 R possibly involved in the metabolism of lipids. Match to protein domains PF08028, PF02771 and PF02770. Acyl-CoA dehydrogenases catalyze the alpha,beta- dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase complement(1804485..1805633) Arthrobacter arilaitensis Re117 9793799 YP_003916769.1 CDS AARI_15790 NC_014550.1 1806095 1808794 R hypothetical protein complement(1806095..1808794) Arthrobacter arilaitensis Re117 9795705 YP_003916770.1 CDS AARI_15800 NC_014550.1 1809160 1809381 D hypothetical protein 1809160..1809381 Arthrobacter arilaitensis Re117 9795706 YP_003916771.1 CDS AARI_15810 NC_014550.1 1809995 1810411 D hypothetical protein 1809995..1810411 Arthrobacter arilaitensis Re117 9793618 YP_003916772.1 CDS orn NC_014550.1 1812011 1812622 R exoribonuclease specific for small oligoribonucleotides. Belongs to the oligoribonuclease family; oligoribonuclease complement(1812011..1812622) Arthrobacter arilaitensis Re117 9793619 YP_003916773.1 CDS AARI_15830 NC_014550.1 1812835 1814358 D 11 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1812835..1814358 Arthrobacter arilaitensis Re117 9794160 YP_003916774.1 CDS AARI_15840 NC_014550.1 1814358 1815839 D 12 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1814358..1815839 Arthrobacter arilaitensis Re117 9795709 YP_003916775.1 CDS AARI_15850 NC_014550.1 1815897 1817000 D 9 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1815897..1817000 Arthrobacter arilaitensis Re117 9795710 YP_003916776.1 CDS AARI_15860 NC_014550.1 1817131 1817907 D similar to excisionases from Mycobacterium phages; phage excisionase 1817131..1817907 Arthrobacter arilaitensis Re117 9795711 YP_003916777.1 CDS AARI_15870 NC_014550.1 1817991 1819091 D match to PF04607. This region of unknown function is found in RelA and SpoT of Escherichia coli, and their homologues in plants and in other eubacteria; RelA/SpoT domain-containing protein 1817991..1819091 Arthrobacter arilaitensis Re117 9795712 YP_003916778.1 CDS AARI_15880 NC_014550.1 1819284 1820885 D TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-2 (Drug RA2) family (TC 3.A.1.121.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family, ARE-subfamily (antibiotic resistance); drug resistance ATP-binding protein 1819284..1820885 Arthrobacter arilaitensis Re117 9795713 YP_003916779.1 CDS AARI_15890 NC_014550.1 1820992 1821399 D hypothetical protein 1820992..1821399 Arthrobacter arilaitensis Re117 9795714 YP_003916780.1 CDS AARI_15900 NC_014550.1 1821473 1822384 R 2 transmembrane helices predicted by TMHMM2.0. Signal peptide predicted by SignalP 3.0 HMM (probability: 0.652) with cleavage site probability 0.343 between position 21 and 22; hypothetical protein complement(1821473..1822384) Arthrobacter arilaitensis Re117 9795715 YP_003916781.1 CDS AARI_15910 NC_014550.1 1822385 1822630 R hypothetical protein complement(1822385..1822630) Arthrobacter arilaitensis Re117 9795716 YP_003916782.1 CDS AARI_15920 NC_014550.1 1822630 1823085 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1822630..1823085) Arthrobacter arilaitensis Re117 9795717 YP_003916783.1 CDS fabG NC_014550.1 1823263 1823985 D catalyses the following reaction: (3R)-3- hydroxyacyl-ACP + NADP(+) <=> 3-oxoacyl- ACP + NADPH. Is involved in fatty acid biosynthesis; 3-oxoacyl-ACP reductase 1823263..1823985 Arthrobacter arilaitensis Re117 9795718 YP_003916784.1 CDS AARI_15940 NC_014550.1 1824020 1824769 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases. Possibly involved in the metabolism of lipid; short-chain dehydrogenases/reductases family protein 1824020..1824769 Arthrobacter arilaitensis Re117 9793839 YP_003916785.1 CDS AARI_15950 NC_014550.1 1825092 1825508 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.997) with cleavage site probability 0.464 between position 32 and 33; hypothetical protein 1825092..1825508 Arthrobacter arilaitensis Re117 9795719 YP_003916786.1 CDS AARI_15960 NC_014550.1 1825639 1827387 R match to PF04294: VanW, VanW like protein. Family members include vancomycin resistance protein W (VanW). Genes encoding members of this family have been found in vancomycin resistance gene clusters vanB and vanG. The function of VanW is unknown; VanW-like protein complement(1825639..1827387) Arthrobacter arilaitensis Re117 9795720 YP_003916787.1 CDS serB NC_014550.1 1827550 1828470 R responsible for the third and final step of the L- serine biosynthetic pathway; phosphoserine phosphatase complement(1827550..1828470) Arthrobacter arilaitensis Re117 9795721 YP_003916788.1 CDS AARI_15980 NC_014550.1 1828651 1829445 D TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC), YLU-family (unclassified systems); ABC transporter ATP-binding subunit 1828651..1829445 Arthrobacter arilaitensis Re117 9794393 YP_003916789.1 CDS AARI_15990 NC_014550.1 1829475 1830272 D 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1829475..1830272 Arthrobacter arilaitensis Re117 9795722 YP_003916790.1 CDS AARI_16000 NC_014550.1 1830277 1831110 D identified by match to protein family PF00588: SpoU rRNA Methylase family. Possible role in rRNA modification; RNA methyltransferase 1830277..1831110 Arthrobacter arilaitensis Re117 9795723 YP_003916791.1 CDS rpmE2 NC_014550.1 1831257 1831514 D part of the 50S ribosomal subunit; 50S ribosomal protein L31 type B 1831257..1831514 Arthrobacter arilaitensis Re117 9795724 YP_003916792.1 CDS lplA NC_014550.1 1831652 1832707 D catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein); lipoate--protein ligase 1831652..1832707 Arthrobacter arilaitensis Re117 9794337 YP_003916793.1 CDS AARI_16030 NC_014550.1 1832720 1833475 R identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase complement(1832720..1833475) Arthrobacter arilaitensis Re117 9794045 YP_003916794.1 CDS pepN NC_014550.1 1833631 1836276 R catalyzes the removal of single amino acids from the amino terminus of small peptides; membrane alanyl aminopeptidase complement(1833631..1836276) Arthrobacter arilaitensis Re117 9795725 YP_003916795.1 CDS AARI_16060 NC_014550.1 1836605 1837165 D hypothetical protein 1836605..1837165 Arthrobacter arilaitensis Re117 9795726 YP_003916796.1 CDS AARI_16070 NC_014550.1 1837411 1837902 D hypothetical protein 1837411..1837902 Arthrobacter arilaitensis Re117 9795727 YP_003916797.1 CDS AARI_16100 NC_014550.1 1838790 1839728 D this family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o- hydroxybenzylidenepyruvate hydratase-aldolase, trans-2- carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3- deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; dihydrodipicolinate synthase family protein 1838790..1839728 Arthrobacter arilaitensis Re117 9795730 YP_003916798.1 CDS AARI_16110 NC_014550.1 1839823 1840269 D match to protein family PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 1839823..1840269 Arthrobacter arilaitensis Re117 9795731 YP_003916799.1 CDS aco NC_014550.1 1840328 1842343 R identified by similarity to potein SP:Q33DR0 (Arthrobacter ureafaciens). Catalyzes the oxidation of acyl-coenzyme A (acyl-CoA) thioester to the corresponding trans-2-enoyl-CoA thioester: acyl-CoA + O2 --> trans-2- enoyl-CoA + H2O2. Probably involved in beta-oxidation of fatty acids; acyl-CoA oxidase complement(1840328..1842343) Arthrobacter arilaitensis Re117 9795732 YP_003916800.1 CDS AARI_16130 NC_014550.1 1842390 1843049 R identified by match to PF00440: bacterial regulatory proteins, tetR family; TetR family transcriptional regulator complement(1842390..1843049) Arthrobacter arilaitensis Re117 9793651 YP_003916801.1 CDS AARI_16140 NC_014550.1 1843125 1844420 D acetyl-CoA C-acyltransferase (also named 3-ketoacyl- CoA thiolase or thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation; acetyl-CoA C-acyltransferase 1843125..1844420 Arthrobacter arilaitensis Re117 9795733 YP_003916802.1 CDS AARI_16150 NC_014550.1 1844420 1845757 D short-chain dehydrogenases/reductases family protein 1844420..1845757 Arthrobacter arilaitensis Re117 9795734 YP_003916803.1 CDS AARI_16160 NC_014550.1 1845758 1846618 D match to PF01575 (MaoC like domain). Enoyl-CoA hydratase is involved in fatty acid metabolism. It catalyzes the hydratation of 2-trans-enoyl-CoA into 3- hydroxyacyl-CoA; enoyl-CoA hydratase 1845758..1846618 Arthrobacter arilaitensis Re117 9795735 YP_003916804.1 CDS AARI_16170 NC_014550.1 1846682 1847866 R match to PF00534: Glycosyl transferases group 1. Proteins containing this domain transfer UDP, ADP, GDP or CMP linked sugars to a variety of substrates, including glycogen, fructose-6-phosphate and lipopolysaccharides. The bacterial enzymes are involved in various biosynthetic processes that include exopolysaccharide biosynthesis, lipopolysaccharide core biosynthesis and the biosynthesis of the slime polysaccaride colanic acid; glycosyl transferase family 1 complement(1846682..1847866) Arthrobacter arilaitensis Re117 9795736 YP_003916805.1 CDS AARI_16180 NC_014550.1 1847933 1848910 R prolyl aminopeptidase releases N-terminal proline from a peptide; prolyl aminopeptidase complement(1847933..1848910) Arthrobacter arilaitensis Re117 9795737 YP_003916806.1 CDS AARI_16190 NC_014550.1 1849016 1849135 D hypothetical protein 1849016..1849135 Arthrobacter arilaitensis Re117 9795738 YP_003916807.1 CDS AARI_16200 NC_014550.1 1850231 1850875 R match to PF03807: NADP oxidoreductase coenzyme F420- dependent; hypothetical protein complement(1850231..1850875) Arthrobacter arilaitensis Re117 9793620 YP_003916808.1 CDS AARI_16210 NC_014550.1 1850956 1852236 R metal ion (Mn2+-iron) transporter (Nramp) family protein (TC 2.A.55.y.z). The generalized transport reaction catalyzed by Nramp family proteins is: Me2+ (out) + H+ (out) --> Me2+ (in) + H+ (in); divalent metal ion transporter complement(1850956..1852236) Arthrobacter arilaitensis Re117 9795740 YP_003916809.1 CDS AARI_16220 NC_014550.1 1852479 1853147 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 1852479..1853147 Arthrobacter arilaitensis Re117 9795741 YP_003916810.1 CDS AARI_16230 NC_014550.1 1853144 1854580 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase 1853144..1854580 Arthrobacter arilaitensis Re117 9795742 YP_003916811.1 CDS AARI_16260 NC_014550.1 1855628 1856944 D identified by match to protein family PF01546: peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification; zinc metallopeptidase 1855628..1856944 Arthrobacter arilaitensis Re117 9795745 YP_003916812.1 CDS AARI_16270 NC_014550.1 1856994 1858133 D Acyl-CoA dehydrogenases catalyze the alpha,beta- dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD. They are involved in the metabolism of lipids; acyl-CoA dehydrogenase 1856994..1858133 Arthrobacter arilaitensis Re117 9795746 YP_003916813.1 CDS AARI_16280 NC_014550.1 1858136 1858369 R hypothetical protein complement(1858136..1858369) Arthrobacter arilaitensis Re117 9795747 YP_003916814.1 CDS AARI_16290 NC_014550.1 1858414 1858623 D hypothetical protein 1858414..1858623 Arthrobacter arilaitensis Re117 9795748 YP_003916815.1 CDS uppP NC_014550.1 1858702 1859526 D catalyses the formation of undecaprenyl phosphate from undecaprenyl diphosphate. Involved in peptidoglycan biosynthesis; undecaprenyl-diphosphatase 1858702..1859526 Arthrobacter arilaitensis Re117 9795749 YP_003916816.1 CDS cysS NC_014550.1 1859654 1860916 D activates cysteine and transfers it to tRNA(Cys) as the first step in protein biosynthesis; cysteine--tRNA ligase 1859654..1860916 Arthrobacter arilaitensis Re117 9794491 YP_003916817.1 CDS AARI_16320 NC_014550.1 1860950 1861858 R hypothetical protein complement(1860950..1861858) Arthrobacter arilaitensis Re117 9793785 YP_003916818.1 CDS AARI_16330 NC_014550.1 1861943 1862656 D identified by match to protein family TIGR01509: HAD-superfamily hydrolase, subfamily IA, variant 3; match to protein family PF00702: haloacid dehalogenase-like hydrolase; hydrolase 1861943..1862656 Arthrobacter arilaitensis Re117 9795750 YP_003916819.1 CDS AARI_16340 NC_014550.1 1862653 1863780 D match to protein family PF02163: Peptidase family M50. Match to PS00142 pattern: neutral zinc metallopeptidases, zinc-binding region signature. 6 transmembrane helices predicted by TMHMM2.0; zinc metallopeptidase 1862653..1863780 Arthrobacter arilaitensis Re117 9795751 YP_003916820.1 CDS AARI_16350 NC_014550.1 1863823 1864884 D identified by match to protein family PF08704: GCD14, tRNA methyltransferase complex GCD14 subunit. tRNA (adenine-N(1)-)-methyltransferase catalyses the following reaction: S-adenosyl-L-methionine + tRNA <=> S-adenosyl-L- homocysteine + tRNA containing N(1)-methyladenine. The enzymes from different sources are specific for different adenine residues in tRNA; tRNA (adenine-N(1)-)-methyltransferase 1863823..1864884 Arthrobacter arilaitensis Re117 9795752 YP_003916821.1 CDS AARI_16360 NC_014550.1 1864985 1866742 D COG1222: RPT1, ATP-dependent 26S proteasome regulatory subunit. Proteasomes are large protein complexes, which main function is to degrade unneeded or damaged proteins; ATP-dependent 26S proteasome regulatory subunit 1864985..1866742 Arthrobacter arilaitensis Re117 9795753 YP_003916822.1 CDS AARI_16370 NC_014550.1 1866739 1868358 D identified by match to protein family PF03136: DUF245, proteasome component. Proteasomes are large protein complexes, which main function is to degrade unneeded or damaged proteins; proteasome component 1866739..1868358 Arthrobacter arilaitensis Re117 9795754 YP_003916823.1 CDS AARI_16380 NC_014550.1 1868425 1868610 D hypothetical protein 1868425..1868610 Arthrobacter arilaitensis Re117 9795755 YP_003916824.1 CDS AARI_16390 NC_014550.1 1868689 1870065 D identified by match to protein family PF03136: DUF245, proteasome component. Proteasomes are large protein complexes, which main function is to degrade unneeded or damaged proteins; proteasome component 1868689..1870065 Arthrobacter arilaitensis Re117 9795756 YP_003916825.1 CDS AARI_16400 NC_014550.1 1870184 1871119 D identified by match to protein family PF00254: FKBP- type peptidyl-prolyl cis-trans isomerase. Peptidylprolyl isomerase is an enzyme that accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Signal peptide predicted by SignalP 3.0 HMM (probability: 1) with cleavage site probability 0.529 between position 27 and 28; peptidylprolyl isomerase 1870184..1871119 Arthrobacter arilaitensis Re117 9795757 YP_003916826.1 CDS AARI_16410 NC_014550.1 1871136 1871531 D identified by match to protein family PF00254: FKBP- type peptidyl-prolyl cis-trans isomerase. Peptidylprolyl isomerase is an enzyme that accelerates protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidylprolyl isomerase 1871136..1871531 Arthrobacter arilaitensis Re117 9795758 YP_003916827.1 CDS AARI_16420 NC_014550.1 1871625 1873628 D transcriptional regulator 1871625..1873628 Arthrobacter arilaitensis Re117 9795759 YP_003916828.1 CDS AARI_16430 NC_014550.1 1873632 1873991 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.673) with cleavage site probability 0.443 between position 23 and 24; hypothetical protein 1873632..1873991 Arthrobacter arilaitensis Re117 9795760 YP_003916829.1 CDS tatA NC_014550.1 1874024 1874239 D identified by match to protein family TIGR01411: twin-arginine translocation protein TatA/E. The twin- arginine translocation system is a Sec-independent exporter for folded proteins, often with a redox cofactor already bound, across the bacterial inner membrane; twin-arginine translocation protein TatA/E 1874024..1874239 Arthrobacter arilaitensis Re117 9795761 YP_003916830.1 CDS tatC NC_014550.1 1874249 1875118 D identified by match to protein family PF00902: Sec- independent protein translocase protein (TatC). The twin- arginine translocation system is a Sec-independent exporter for folded proteins, often with a redox cofactor already bound, across the bacterial inner membrane; twin-arginine translocation protein TatC 1874249..1875118 Arthrobacter arilaitensis Re117 9794425 YP_003916831.1 CDS AARI_16460 NC_014550.1 1875147 1877930 D DEAD box helicase. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression; ATP-dependent RNA helicase 1875147..1877930 Arthrobacter arilaitensis Re117 9794427 YP_003916832.1 CDS AARI_16470 NC_014550.1 1877987 1879594 D identified by match to protein family PF07969: amidohydrolase family; amidohydrolase family protein 1877987..1879594 Arthrobacter arilaitensis Re117 9795762 YP_003916833.1 CDS AARI_16480 NC_014550.1 1880009 1880737 D match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 1880009..1880737 Arthrobacter arilaitensis Re117 9795763 YP_003916834.1 CDS AARI_16490 NC_014550.1 1880951 1881298 R hypothetical protein complement(1880951..1881298) Arthrobacter arilaitensis Re117 9795764 YP_003916835.1 CDS AARI_16500 NC_014550.1 1881483 1882421 R identified by match to protein family PF01145. The band 7 protein is an integral membrane protein which is thought to regulate cation conductance. A variety of proteins belong to this family; band 7 family protein complement(1881483..1882421) Arthrobacter arilaitensis Re117 9795765 YP_003916836.1 CDS AARI_16510 NC_014550.1 1882479 1882955 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1882479..1882955) Arthrobacter arilaitensis Re117 9795766 YP_003916837.1 CDS rrmA NC_014550.1 1883060 1883911 R rRNA methyltransferase catalyzes the following reaction: S-adenosyl-L-methionine + rRNA => S-adenosyl-L- homocysteine + rRNA containing N(1)-methylguanine. It is required for translation and cell growth; rRNA (guanine-N(1)-)-methyltransferase complement(1883060..1883911) Arthrobacter arilaitensis Re117 9795767 YP_003916838.1 CDS def NC_014550.1 1883911 1884552 R involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides; peptide deformylase complement(1883911..1884552) Arthrobacter arilaitensis Re117 9794369 YP_003916839.1 CDS AARI_16540 NC_014550.1 1884549 1885601 R identified by match to protein family PF03969: AFG1_ATPase, AFG1-like ATPase; ATPase complement(1884549..1885601) Arthrobacter arilaitensis Re117 9793800 YP_003916840.1 CDS AARI_16550 NC_014550.1 1885924 1886271 D identified by match to PF01022. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator 1885924..1886271 Arthrobacter arilaitensis Re117 9795768 YP_003916841.1 CDS AARI_16560 NC_014550.1 1886467 1886937 D match to protein family PF03969: activator of Hsp90 ATPase homolog 1-like protein; hypothetical protein 1886467..1886937 Arthrobacter arilaitensis Re117 9795769 YP_003916842.1 CDS AARI_16570 NC_014550.1 1887275 1887736 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1887275..1887736 Arthrobacter arilaitensis Re117 9795770 YP_003916843.1 CDS AARI_16580 NC_014550.1 1887870 1888844 R identified by match to protein family PF01758. Bile acid:Na+ symporter (BASS) family (TC 2.A.28.y.z): these symporters exhibit broad specificity, taking up a variety of non bile organic compounds as well as taurocholate and other bile salts; sodium-dependent transporter complement(1887870..1888844) Arthrobacter arilaitensis Re117 9795771 YP_003916844.1 CDS AARI_16590 NC_014550.1 1888989 1889363 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1888989..1889363 Arthrobacter arilaitensis Re117 9795772 YP_003916845.1 CDS AARI_16600 NC_014550.1 1889352 1889894 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1889352..1889894) Arthrobacter arilaitensis Re117 9795773 YP_003916846.1 CDS AARI_16610 NC_014550.1 1889895 1890491 R hypothetical protein complement(1889895..1890491) Arthrobacter arilaitensis Re117 9795774 YP_003916847.1 CDS AARI_16620 NC_014550.1 1890654 1890938 D identified by match to protein family PF01037: AsnC_trans_reg, AsnC family; AsnC/Lrp family transcriptional regulator 1890654..1890938 Arthrobacter arilaitensis Re117 9795775 YP_003916848.1 CDS trpD NC_014550.1 1891026 1892045 R involved in tryptophane biosynthesis; anthranilate phosphoribosyltransferase complement(1891026..1892045) Arthrobacter arilaitensis Re117 9795776 YP_003916849.1 CDS ctaE NC_014550.1 1892381 1893019 D in Corynebacterium glutamicum, a cytochrome aa3 terminal oxidase (EC 1.9.3.1) receives electrons from a bc1 complex (EC 1.10.2.2). The bc1 complex is encoded by qcrA (Rieske iron-sulfur protein), qcrB (cytochrome B) and qcrC (cytochrome c1). Cytochrome aa3 is composed of subunits I (ctaD), II (ctaC), III (ctaE) and IV (ctaF). These subunits form the cytochrome bc1-aa3 supercomplex; cytochrome aa3 subunit 3 1892381..1893019 Arthrobacter arilaitensis Re117 9794469 YP_003916850.1 CDS qcrC NC_014550.1 1893096 1893890 D in Corynebacterium glutamicum, a cytochrome aa3 terminal oxidase (EC 1.9.3.1) receives electrons from a bc1 complex (EC 1.10.2.2). The bc1 complex is encoded by qcrA (Rieske iron-sulfur protein), qcrB (cytochrome B) and qcrC (cytochrome c1). Cytochrome aa3 is composed of subunits I (ctaD), II (ctaC), III (ctaE) and IV (ctaF). These subunits form the cytochrome bc1-aa3 supercomplex; cytochrome bc1 complex cytochrome c1 subunit 1893096..1893890 Arthrobacter arilaitensis Re117 9793766 YP_003916851.1 CDS qcrA NC_014550.1 1893961 1895010 D in Corynebacterium glutamicum, a cytochrome aa3 terminal oxidase (EC 1.9.3.1) receives electrons from a bc1 complex (EC 1.10.2.2). The bc1 complex is encoded by qcrA (Rieske iron-sulfur protein), qcrB (cytochrome B) and qcrC (cytochrome c1). Cytochrome aa3 is composed of subunits I (ctaD), II (ctaC), III (ctaE) and IV (ctaF). These subunits form the cytochrome bc1-aa3 supercomplex; cytochrome bc1 complex iron sulfur subunit 1893961..1895010 Arthrobacter arilaitensis Re117 9794277 YP_003916852.1 CDS qcrB NC_014550.1 1895013 1896683 D in Corynebacterium glutamicum, a cytochrome aa3 terminal oxidase (EC 1.9.3.1) receives electrons from a bc1 complex (EC 1.10.2.2). The bc1 complex is encoded by qcrA (Rieske iron-sulfur protein), qcrB (cytochrome B) and qcrC (cytochrome c1). Cytochrome aa3 is composed of subunits I (ctaD), II (ctaC), III (ctaE) and IV (ctaF). These subunits form the cytochrome bc1-aa3 supercomplex; cytochrome bc1 complex cytochrome b subunit 1895013..1896683 Arthrobacter arilaitensis Re117 9794275 YP_003916853.1 CDS AARI_16680 NC_014550.1 1897400 1898182 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(1897400..1898182) Arthrobacter arilaitensis Re117 9794276 YP_003916854.1 CDS ctaF NC_014550.1 1898296 1898697 R in Corynebacterium glutamicum, a cytochrome aa3 terminal oxidase (EC 1.9.3.1) receives electrons from a bc1 complex (EC 1.10.2.2). The bc1 complex is encoded by qcrA (Rieske iron-sulfur protein), qcrB (cytochrome B) and qcrC (cytochrome c1). Cytochrome aa3 is composed of subunits I (ctaD), II (ctaC), III (ctaE) and IV (ctaF). These subunits form the cytochrome bc1-aa3 supercomplex; cytochrome aa3 subunit 4 complement(1898296..1898697) Arthrobacter arilaitensis Re117 9795777 YP_003916855.1 CDS ctaD NC_014550.1 1898700 1900418 R in Corynebacterium glutamicum, a cytochrome aa3 terminal oxidase (EC 1.9.3.1) receives electrons from a bc1 complex (EC 1.10.2.2). The bc1 complex is encoded by qcrA (Rieske iron-sulfur protein), qcrB (cytochrome B) and qcrC (cytochrome c1). Cytochrome aa3 is composed of subunits I (ctaD), II (ctaC), III (ctaE) and IV (ctaF). These subunits form the cytochrome bc1-aa3 supercomplex; cytochrome aa3 subunit 1 complement(1898700..1900418) Arthrobacter arilaitensis Re117 9793767 YP_003916856.1 CDS ctaC NC_014550.1 1900421 1901344 R in Corynebacterium glutamicum, a cytochrome aa3 terminal oxidase (EC 1.9.3.1) receives electrons from a bc1 complex (EC 1.10.2.2). The bc1 complex is encoded by qcrA (Rieske iron-sulfur protein), qcrB (cytochrome B) and qcrC (cytochrome c1). Cytochrome aa3 is composed of subunits I (ctaD), II (ctaC), III (ctaE) and IV (ctaF). These subunits form the cytochrome bc1-aa3 supercomplex; cytochrome aa3 subunit 2 complement(1900421..1901344) Arthrobacter arilaitensis Re117 9793765 YP_003916857.1 CDS AARI_16720 NC_014550.1 1901517 1901891 R identified by match to protein family TIGR00049; iron-sulfur cluster assembly accessory protein complement(1901517..1901891) Arthrobacter arilaitensis Re117 9793764 YP_003916858.1 CDS AARI_16730 NC_014550.1 1902026 1903435 R identified by match to protein family PF01546: peptidase family M20/M25/M40. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification; zinc metallopeptidase complement(1902026..1903435) Arthrobacter arilaitensis Re117 9795778 YP_003916859.1 CDS AARI_16740 NC_014550.1 1903505 1904098 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1903505..1904098 Arthrobacter arilaitensis Re117 9795779 YP_003916860.1 CDS pyrD NC_014550.1 1904466 1905530 R catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate; dihydroorotate oxidase complement(1904466..1905530) Arthrobacter arilaitensis Re117 9795780 YP_003916861.1 CDS AARI_16760 NC_014550.1 1905591 1906628 D match to PF00561: alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; hydrolase 1905591..1906628 Arthrobacter arilaitensis Re117 9794267 YP_003916862.1 CDS uppS2 NC_014550.1 1906635 1907441 R generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide; di-trans,poly-cis-decaprenylcistransferase complement(1906635..1907441) Arthrobacter arilaitensis Re117 9795781 YP_003916863.1 CDS recO NC_014550.1 1907438 1908187 R involved in DNA repair and recF pathway recombination; DNA repair protein RecO complement(1907438..1908187) Arthrobacter arilaitensis Re117 9794493 YP_003916864.1 CDS leuA NC_014550.1 1908291 1910003 R catalyzes the first step in the biosynthesis of leucine, the condensation of acetyl-CoA and 2- oxoisovalerate to form 2-isopropylmalate; 2-isopropylmalate synthase complement(1908291..1910003) Arthrobacter arilaitensis Re117 9794290 YP_003916865.1 CDS AARI_16800 NC_014550.1 1910323 1911495 D FAD-dependent oxidoreductase 1910323..1911495 Arthrobacter arilaitensis Re117 9794031 YP_003916866.1 CDS era NC_014550.1 1911576 1912538 R in Escherichia coli, the protein Era is involved in 16S rRNA maturation and ribosome assembly; GTP-binding protein Era complement(1911576..1912538) Arthrobacter arilaitensis Re117 9795782 YP_003916867.1 CDS AARI_16820 NC_014550.1 1912531 1913817 R possible transporter. Match to PF00571 (CBS domain pair); CBS domain-containing transporter complement(1912531..1913817) Arthrobacter arilaitensis Re117 9793836 YP_003916868.1 CDS AARI_16830 NC_014550.1 1913822 1914295 R metalloprotease complement(1913822..1914295) Arthrobacter arilaitensis Re117 9795783 YP_003916869.1 CDS AARI_16840 NC_014550.1 1914292 1915320 R identified by match to protein family PF02562: PhoH, PhoH-like protein. PhoH is a cytoplasmic protein and predicted ATPase that is induced by phosphate starvation; PhoH-like protein complement(1914292..1915320) Arthrobacter arilaitensis Re117 9795784 YP_003916870.1 CDS AARI_16850 NC_014550.1 1915508 1916539 D hypothetical protein 1915508..1916539 Arthrobacter arilaitensis Re117 9795785 YP_003916871.1 CDS AARI_16860 NC_014550.1 1916835 1917608 R hypothetical protein complement(1916835..1917608) Arthrobacter arilaitensis Re117 9795786 YP_003916872.1 CDS dnaJ NC_014550.1 1917611 1918735 R involved in protein folding and renaturation after stress; chaperone protein DnaJ complement(1917611..1918735) Arthrobacter arilaitensis Re117 9795787 YP_003916873.1 CDS hrcA NC_014550.1 1918802 1919815 R match to protein family PF01628: HrcA protein C terminal domain. HrcA is found to negatively regulate the transcription of heat shock genes; heat-inducible transcription repressor HrcA complement(1918802..1919815) Arthrobacter arilaitensis Re117 9793825 YP_003916874.1 CDS AARI_16890 NC_014550.1 1919943 1920815 D hypothetical protein 1919943..1920815 Arthrobacter arilaitensis Re117 9793976 YP_003916875.1 CDS AARI_16900 NC_014550.1 1920904 1921305 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 1920904..1921305 Arthrobacter arilaitensis Re117 9795788 YP_003916876.1 CDS hemF NC_014550.1 1921322 1922551 R catalyzes the oxidative decarboxylation of coproporphyrinogen III into protoporphyrinogen IX, a common step in the pathway for the biosynthesis of porphyrins such as heme, chlorophyll or cobalamin: coproporphyrinogen-III + O(2) + 2 H(+) <=> protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O; coproporphyrinogen oxidase complement(1921322..1922551) Arthrobacter arilaitensis Re117 9795789 YP_003916877.1 CDS lepA NC_014550.1 1922552 1924390 R the extremely conserved LepA protein, present in all bacteria and mitochondria, is an elongation factor required for accurate and efficient protein synthesis; GTP-binding elongation factor LepA complement(1922552..1924390) Arthrobacter arilaitensis Re117 9793954 YP_003916878.1 CDS AARI_16930 NC_014550.1 1924512 1925081 D hypothetical protein 1924512..1925081 Arthrobacter arilaitensis Re117 9794029 YP_003916879.1 CDS rpsT NC_014550.1 1925252 1925512 D Binds directly to 16S ribosomal RNA; 30S ribosomal protein S20 1925252..1925512 Arthrobacter arilaitensis Re117 9795790 YP_003916880.1 CDS holA NC_014550.1 1925667 1926659 R DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta prime, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit delta complement(1925667..1926659) Arthrobacter arilaitensis Re117 9794367 YP_003916881.1 CDS AARI_16960 NC_014550.1 1926694 1928961 R identified by match to protein family PF03772, some members of this family have been shown to be essential for bacterial competence in uptake of extracellular DNA. 10 transmembrane helices predicted by TMHMM2.0; competence protein complement(1926694..1928961) Arthrobacter arilaitensis Re117 9793970 YP_003916882.1 CDS AARI_16970 NC_014550.1 1928958 1929605 R helix-hairpin-helix DNA-binding domain. The HhH motif is an around 20 amino acids domain present in prokaryotic and eukaryotic non-sequence-specific DNA binding proteins; DNA uptake protein complement(1928958..1929605) Arthrobacter arilaitensis Re117 9795791 YP_003916883.1 CDS AARI_16980 NC_014550.1 1929621 1930559 R identified by match to protein family PF02645: uncharacterised protein, DegV family COG1307. The structure of this protein revealed a bound fatty-acid molecule in a pocket between the two protein domains. The structure indicates that this family has the molecular function of fatty-acid binding and may play a role in the cellular functions of fatty acid transport or metabolism; DegV family protein complement(1929621..1930559) Arthrobacter arilaitensis Re117 9795792 YP_003916884.1 CDS leuS NC_014550.1 1930569 1933058 R leucine-tRNA ligase complement(1930569..1933058) Arthrobacter arilaitensis Re117 9795793 YP_003916885.1 CDS AARI_17000 NC_014550.1 1933347 1935197 D match to HNH endonuclease signature (cd00085); HNH endonuclease domain-containing protein 1933347..1935197 Arthrobacter arilaitensis Re117 9794035 YP_003916886.1 CDS glpK NC_014550.1 1935288 1936808 R catalyzes the Mg-ATP-dependent phosphorylation of glycerol to yield glycerol 3-phosphate. Key enzyme of glycerol metabolism in bacteria, phosphorylation of glycerol prevents diffusion through the membrane; glycerol kinase complement(1935288..1936808) Arthrobacter arilaitensis Re117 9795794 YP_003916887.1 CDS glpF NC_014550.1 1936826 1937554 R glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically important processes. Belongs to the the Major Intrinsic Protein (MIP) family (TC 1.A.8.y.z); glycerol uptake facilitator protein complement(1936826..1937554) Arthrobacter arilaitensis Re117 9793911 YP_003916888.1 CDS glpD NC_014550.1 1937614 1939293 R catalyzes the following reaction: sn-glycerol-3- phosphate + acceptor = glycerone phosphate + reduced acceptor. In bacteria, it is associated with the utilization of glycerol coupled to respiration; glycerol-3-phosphate dehydrogenase complement(1937614..1939293) Arthrobacter arilaitensis Re117 9793910 YP_003916889.1 CDS AARI_17040 NC_014550.1 1939400 1940407 D transcriptional regulator 1939400..1940407 Arthrobacter arilaitensis Re117 9793909 YP_003916890.1 CDS AARI_17050 NC_014550.1 1940417 1941289 D match to PS00120 pattern: lipases, serine active site; lipase/esterase 1940417..1941289 Arthrobacter arilaitensis Re117 9795795 YP_003916891.1 CDS priA NC_014550.1 1941286 1943247 R formation of the primosome proceeds with the subsequent actions of dnaB, dnaC, dnaT and primase. PriA then functions as a helicase within the primosome; primosomal protein PriA complement(1941286..1943247) Arthrobacter arilaitensis Re117 9795796 YP_003916892.1 CDS metK NC_014550.1 1943257 1944462 R catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is an important methyl donor for transmethylation and is also the propylamino donor in polyamine biosynthesis; methionine adenosyltransferase complement(1943257..1944462) Arthrobacter arilaitensis Re117 9794222 YP_003916893.1 CDS coaBC NC_014550.1 1944563 1945765 R catalyzes two steps in the biosynthesis of coenzyme A: EC 6.3.2.5 conjugues cysteine to 4-phosphopantothenate to form 4-phosphopantothenoylcysteine (CTP + (R)-4- phosphopantothenate + L-cysteine = CMP + PPi + N-((R)-4- phosphopantothenoyl)-L-cysteine), EC 4.1.1.36 decarboxylates 4-phosphopantothenoylcysteine to form 4- phosphopantotheine (N-((R)-4-phosphopantothenoyl)-L- cysteine = pantotheine 4-phosphate + CO2); bifunctional phosphopantothenate-cysteine ligase/phosphopantothenoylcysteine decarboxylase complement(1944563..1945765) Arthrobacter arilaitensis Re117 9794074 YP_003916894.1 CDS rpoZ NC_014550.1 1945863 1946123 R DNA-directed RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; DNA-directed RNA polymerase omega chain complement(1945863..1946123) Arthrobacter arilaitensis Re117 9793748 YP_003916895.1 CDS gmk NC_014550.1 1946132 1946698 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine diphosphate (GDP). It plays an essential role in the biosynthesis of guanosine triphosphate (GTP); guanylate kinase complement(1946132..1946698) Arthrobacter arilaitensis Re117 9794347 YP_003916896.1 CDS AARI_17110 NC_014550.1 1946702 1947037 R match to SM00278 (Helix-hairpin-helix DNA-binding motif, class 1); DNA-binding protein complement(1946702..1947037) Arthrobacter arilaitensis Re117 9793929 YP_003916897.1 CDS pyrF NC_014550.1 1947184 1948026 R decarboxylates orotidine-5-phosphate to form uridine 5-phosphate (UMP). Involved in pyrimidine biosynthesis; orotidine-5'-phosphate decarboxylase complement(1947184..1948026) Arthrobacter arilaitensis Re117 9795797 YP_003916898.1 CDS carB NC_014550.1 1948019 1951297 R carbamoyl-phosphate synthase is involved in both arginine and pyrimidine biosynthesis and catalyzes the ATP- dependent formation of carbamoyl-phosphate from glutamine and carbon dioxide. In bacteria it is composed of two subunits: a large chain (gene carB) and a small chain (gene carA); carbamoyl-phosphate synthase (glutamine-hydrolyzing) large subunit complement(1948019..1951297) Arthrobacter arilaitensis Re117 9794271 YP_003916899.1 CDS carA NC_014550.1 1951297 1952466 R carbamoyl-phosphate synthase is involved in both arginine and pyrimidine biosynthesis and catalyzes the ATP- dependent formation of carbamoyl-phosphate from glutamine and carbon dioxide. In bacteria it is composed of two subunits: a large chain (gene carB) and a small chain (gene carA); carbamoyl-phosphate synthase (glutamine-hydrolyzing) small subunit complement(1951297..1952466) Arthrobacter arilaitensis Re117 9793726 YP_003916900.1 CDS AARI_17150 NC_014550.1 1952467 1952973 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(1952467..1952973) Arthrobacter arilaitensis Re117 9793725 YP_003916901.1 CDS pyrC NC_014550.1 1952966 1954270 R catalyzes the third step in the de novo biosynthesis of pyrimidine, the conversion of N-carbamoyl- L-aspartate into dihydroorotate; dihydroorotase complement(1952966..1954270) Arthrobacter arilaitensis Re117 9795798 YP_003916902.1 CDS pyrB NC_014550.1 1954282 1955244 R catalyzes the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate, the second step in the de novo biosynthesis of pyrimidine; aspartate carbamoyltransferase complement(1954282..1955244) Arthrobacter arilaitensis Re117 9794265 YP_003916903.1 CDS pyrR NC_014550.1 1955241 1955810 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes. Has also a uracil phosphoribosyltransferase activity: formation of UMP and diphosphate from uracil and 5-phospho-alpha-D-ribose 1- diphosphate; bifunctional protein pyrR complement(1955241..1955810) Arthrobacter arilaitensis Re117 9794264 YP_003916904.1 CDS AARI_17190 NC_014550.1 1955997 1956479 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.881) with cleavage site probability 0.567 between position 37 and 38; hypothetical protein 1955997..1956479 Arthrobacter arilaitensis Re117 9794274 YP_003916905.1 CDS AARI_17200 NC_014550.1 1956286 1956636 R hypothetical protein complement(1956286..1956636) Arthrobacter arilaitensis Re117 9795799 YP_003916906.1 CDS nusB NC_014550.1 1956748 1957158 R regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination factor NusB complement(1956748..1957158) Arthrobacter arilaitensis Re117 9795800 YP_003916907.1 CDS efp NC_014550.1 1957158 1957718 R required for efficient translation; elongation factor P complement(1957158..1957718) Arthrobacter arilaitensis Re117 9794154 YP_003916908.1 CDS AARI_17230 NC_014550.1 1957829 1958359 R hypothetical protein complement(1957829..1958359) Arthrobacter arilaitensis Re117 9793833 YP_003916909.1 CDS aroB NC_014550.1 1958364 1959455 R involved in phenylalanine, tyrosine and tryptophan biosynthesis; 3-dehydroquinate synthase complement(1958364..1959455) Arthrobacter arilaitensis Re117 9795801 YP_003916910.1 CDS aroK NC_014550.1 1959535 1960023 R fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone; shikimate kinase complement(1959535..1960023) Arthrobacter arilaitensis Re117 9793683 YP_003916911.1 CDS aroC NC_014550.1 1960037 1961236 R last enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone; chorismate synthase complement(1960037..1961236) Arthrobacter arilaitensis Re117 9793688 YP_003916912.1 CDS aroE NC_014550.1 1961266 1962105 R fourth enzyme in the shikimate pathway, a seven- step biosynthetic pathway which converts erythrose-4- phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone; shikimate dehydrogenase complement(1961266..1962105) Arthrobacter arilaitensis Re117 9793684 YP_003916913.1 CDS AARI_17280 NC_014550.1 1962177 1963622 R aminodeoxychorismate lyase converts 4- aminodeoxychorismate to pyruvate and p-aminobenzoate, a precursor of folic acid in bacteria. Identified by match to protein family PF02618; aminodeoxychorismate lyase complement(1962177..1963622) Arthrobacter arilaitensis Re117 9793685 YP_003916914.1 CDS AARI_17290 NC_014550.1 1963668 1964141 R identified by match to protein family TIGR00250. Could be a nuclease that resolves Holliday junction intermediates in genetic recombination; Holliday junction resolvase complement(1963668..1964141) Arthrobacter arilaitensis Re117 9795802 YP_003916915.1 CDS alaS NC_014550.1 1964134 1966824 R alanine-tRNA ligase complement(1964134..1966824) Arthrobacter arilaitensis Re117 9795803 YP_003916916.1 CDS AARI_17310 NC_014550.1 1966844 1967053 R hypothetical protein complement(1966844..1967053) Arthrobacter arilaitensis Re117 9793660 YP_003916917.1 CDS AARI_17320 NC_014550.1 1967134 1967505 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.558) with cleavage site probability 0.558 between position 23 and 24; hypothetical protein complement(1967134..1967505) Arthrobacter arilaitensis Re117 9795804 YP_003916918.1 CDS rpsD NC_014550.1 1967632 1968255 R One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit; 30S ribosomal protein S20 complement(1967632..1968255) Arthrobacter arilaitensis Re117 9795805 YP_003916919.1 CDS rarA NC_014550.1 1968442 1969848 R replication-associated recombination protein A complement(1968442..1969848) Arthrobacter arilaitensis Re117 9794351 YP_003916920.1 CDS dtd NC_014550.1 1969938 1970375 D cell growth inhibition by several D-amino acids can be explained by an in vivo production of D-aminoacyl-tRNA molecules. D-tyrosyl-tRNA(Tyr) deacylase cleaves any D- amino acid (and glycine, which does not have distinct D/L forms) from charged tRNA; D-tyrosyl-tRNA(Tyr) deacylase 1969938..1970375 Arthrobacter arilaitensis Re117 9794281 YP_003916921.1 CDS AARI_17360 NC_014550.1 1970372 1970701 R identified by match to protein family PF03551; PadR-like family transcriptional regulator complement(1970372..1970701) Arthrobacter arilaitensis Re117 9793829 YP_003916922.1 CDS AARI_17370 NC_014550.1 1970694 1971812 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(1970694..1971812) Arthrobacter arilaitensis Re117 9795806 YP_003916923.1 CDS AARI_35240 NC_014550.1 1971908 1973185 R transposase of ISAar15, ISL3 family complement(1971908..1973185) Arthrobacter arilaitensis Re117 9795807 YP_003916924.1 CDS aspS NC_014550.1 1973387 1975174 R activates aspartate and transfers it to tRNA(Asp) as the first step in protein biosynthesis; aspartate--tRNA ligase complement(1973387..1975174) Arthrobacter arilaitensis Re117 9793466 YP_003916925.1 CDS hisS NC_014550.1 1975264 1976586 R activates histidine and transfers it to tRNA(His) as the first step in protein biosynthesis; histidine--tRNA ligase complement(1975264..1976586) Arthrobacter arilaitensis Re117 9793698 YP_003916926.1 CDS AARI_17400 NC_014550.1 1976730 1978088 D hypothetical protein 1976730..1978088 Arthrobacter arilaitensis Re117 9793969 YP_003916927.1 CDS AARI_17410 NC_014550.1 1978149 1978772 D hypothetical protein 1978149..1978772 Arthrobacter arilaitensis Re117 9795808 YP_003916928.1 CDS AARI_17420 NC_014550.1 1978801 1981068 R GTP diphosphokinase (EC 2.7.6.5) produces pppGpp (or ppGpp) from ATP and GTP (or GDP). Guanosine-3,5- bis(diphosphate) 3-diphosphatase (EC 3.1.7.2) hydrolyzes ppGpp into GTP. In eubacteria ppGpp is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance; bifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase complement(1978801..1981068) Arthrobacter arilaitensis Re117 9795809 YP_003916929.1 CDS secF NC_014550.1 1981309 1982277 R identified by match to protein family PF02355. The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF); protein-export membrane protein SecF complement(1981309..1982277) Arthrobacter arilaitensis Re117 9795810 YP_003916930.1 CDS secD NC_014550.1 1982270 1984012 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.509 between position 32 and 33. The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF); protein-export membrane protein SecD complement(1982270..1984012) Arthrobacter arilaitensis Re117 9794389 YP_003916931.1 CDS yajC NC_014550.1 1984073 1984483 R match to bacterial YajC preprotein translocase signature PR02699. The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF). Other cytoplasmic/periplasmic proteins play a part in preprotein translocase activity, namely YidC and YajC. The latter is bound in a complex to SecD and SecF, and plays a part in stabilising and regulating secretion through the SecYEG integral membrane component via SecA; preprotein translocase subunit YajC complement(1984073..1984483) Arthrobacter arilaitensis Re117 9794387 YP_003916932.1 CDS ruvB NC_014550.1 1984671 1985720 R the RuvB protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair; Holliday junction ATP-dependent DNA helicase RuvB complement(1984671..1985720) Arthrobacter arilaitensis Re117 9794516 YP_003916933.1 CDS ruvA NC_014550.1 1985748 1986365 R the RuvA protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair; Holliday junction ATP-dependent DNA helicase RuvA complement(1985748..1986365) Arthrobacter arilaitensis Re117 9794372 YP_003916934.1 CDS ruvC NC_014550.1 1986473 1987072 R the RuvC protein makes up part of the RuvABC revolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair; crossover junction endodeoxyribonuclease RuvC complement(1986473..1987072) Arthrobacter arilaitensis Re117 9794371 YP_003916935.1 CDS AARI_17490 NC_014550.1 1987076 1987834 R hypothetical protein complement(1987076..1987834) Arthrobacter arilaitensis Re117 9794373 YP_003916936.1 CDS pdxT NC_014550.1 1987838 1988449 R involved in pyridoxal biosynthesis. Hydrolyses glutamine to glutamate and ammonia. Channels an ammonia molecule to pdxS; glutamine amidotransferase subunit PdxT complement(1987838..1988449) Arthrobacter arilaitensis Re117 9795811 YP_003916937.1 CDS dkgA NC_014550.1 1988607 1989440 D catalyzes the reduction of 2,5-diketogluconic acid to 2-keto-L-gulonic acid, a key intermediate in the production of ascorbic acid. Can also reduce ethyl 2- methylacetoacetate stereoselectively to ethyl (2R)-methyl- (3S)-hydroxybutanoate and can also accept some other beta- keto esters. Identified by similarity to protein SP:Q46857 (Escherichia coli); 2,5-didehydrogluconate reductase 1988607..1989440 Arthrobacter arilaitensis Re117 9794191 YP_003916938.1 CDS AARI_17520 NC_014550.1 1989486 1989611 D hypothetical protein 1989486..1989611 Arthrobacter arilaitensis Re117 9793818 YP_003916939.1 CDS AARI_17530 NC_014550.1 1989633 1990121 D hypothetical protein 1989633..1990121 Arthrobacter arilaitensis Re117 9795812 YP_003916940.1 CDS AARI_17540 NC_014550.1 1990123 1991325 R identified by match to PF09587. Poly-gamma- glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein; poly-gamma-glutamate capsule biosynthesis protein complement(1990123..1991325) Arthrobacter arilaitensis Re117 9795813 YP_003916941.1 CDS dcp NC_014550.1 1991402 1993414 D hydrolyzes unblocked, C-terminal dipeptides from oligopeptides, with broad specificity; peptidyl-dipeptidase 1991402..1993414 Arthrobacter arilaitensis Re117 9795814 YP_003916942.1 CDS AARI_17560 NC_014550.1 1993414 1994181 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 1993414..1994181 Arthrobacter arilaitensis Re117 9793795 YP_003916943.1 CDS AARI_17570 NC_014550.1 1994256 1994816 R match to protein domain PF01872. This domain is found in the C-terminus of the bifunctional deaminase- reductase in combination with PF00383 as well as in isolation in some archaebacterial proteins; RibD domain-containing protein complement(1994256..1994816) Arthrobacter arilaitensis Re117 9794519 YP_003916944.1 CDS AARI_17590 NC_014550.1 1995874 1996026 R hypothetical protein complement(1995874..1996026) Arthrobacter arilaitensis Re117 9794521 YP_003916945.1 CDS pdxS NC_014550.1 1996494 1997396 R combines ammonia with five- and three-carbon phosphosugars to form PLP (pyridoxal 5-phosphate) which is the biologically active form of vitamin B6. Forms a complex with pdxT; pyridoxal biosynthesis lyase PdxS complement(1996494..1997396) Arthrobacter arilaitensis Re117 9794522 YP_003916946.1 CDS AARI_17610 NC_014550.1 1997976 1998542 R match to PF01230: histidine triad motif. The histidine triad motif (HIT) is related to the sequence H- phi-H-phi-H-phi-phi (where phi is a hydrophobic amino acid). Proteins containing HIT domains form a superfamily of nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides; histidine triad family protein complement(1997976..1998542) Arthrobacter arilaitensis Re117 9794190 YP_003916947.1 CDS thrS NC_014550.1 1998566 2000581 R activates threonine and transfers it to tRNA(Thr) as the first step in protein biosynthesis; threonine--tRNA ligase complement(1998566..2000581) Arthrobacter arilaitensis Re117 9794523 YP_003916948.1 CDS AARI_17630 NC_014550.1 2000690 2000824 R hypothetical protein complement(2000690..2000824) Arthrobacter arilaitensis Re117 9794451 YP_003916949.1 CDS AARI_17640 NC_014550.1 2001120 2001707 D hypothetical protein 2001120..2001707 Arthrobacter arilaitensis Re117 9794524 YP_003916950.1 CDS AARI_17650 NC_014550.1 2001963 2002070 R hypothetical protein complement(2001963..2002070) Arthrobacter arilaitensis Re117 9794525 YP_003916951.1 CDS AARI_17660 NC_014550.1 2002207 2002647 D identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein 2002207..2002647 Arthrobacter arilaitensis Re117 9794526 YP_003916952.1 CDS dnaE NC_014550.1 2002648 2006103 R DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta prime, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit alpha complement(2002648..2006103) Arthrobacter arilaitensis Re117 9794527 YP_003916953.1 CDS AARI_17680 NC_014550.1 2006141 2006455 R hypothetical protein complement(2006141..2006455) Arthrobacter arilaitensis Re117 9793822 YP_003916954.1 CDS AARI_17690 NC_014550.1 2006541 2006762 D hypothetical protein 2006541..2006762 Arthrobacter arilaitensis Re117 9794528 YP_003916955.1 CDS AARI_17700 NC_014550.1 2006927 2008012 D catalyses the following reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+. The S- formylmycothiol formed hydrolyses to mycothiol and formate; mycothiol-dependent formaldehyde dehydrogenase 2006927..2008012 Arthrobacter arilaitensis Re117 9794529 YP_003916956.1 CDS AARI_17710 NC_014550.1 2008012 2008641 D identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase 2008012..2008641 Arthrobacter arilaitensis Re117 9794530 YP_003916957.1 CDS AARI_17720 NC_014550.1 2008738 2009250 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2008738..2009250 Arthrobacter arilaitensis Re117 9794531 YP_003916958.1 CDS AARI_17730 NC_014550.1 2009247 2009975 R hypothetical protein complement(2009247..2009975) Arthrobacter arilaitensis Re117 9794532 YP_003916959.1 CDS AARI_17740 NC_014550.1 2010102 2010380 D identified by match to protein family PF00462; glutaredoxin-like protein 2010102..2010380 Arthrobacter arilaitensis Re117 9794533 YP_003916960.1 CDS AARI_17750 NC_014550.1 2010436 2011140 R hypothetical protein complement(2010436..2011140) Arthrobacter arilaitensis Re117 9794534 YP_003916961.1 CDS AARI_17760 NC_014550.1 2011269 2011883 D uridine kinase catalyzes the phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP; uridine kinase-like protein 2011269..2011883 Arthrobacter arilaitensis Re117 9794535 YP_003916962.1 CDS AARI_17770 NC_014550.1 2011880 2012698 R hypothetical protein complement(2011880..2012698) Arthrobacter arilaitensis Re117 9794536 YP_003916963.1 CDS AARI_17780 NC_014550.1 2012772 2013347 R match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein complement(2012772..2013347) Arthrobacter arilaitensis Re117 9794537 YP_003916964.1 CDS AARI_17790 NC_014550.1 2013422 2014339 D match to PF07992: pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases; oxidoreductase 2013422..2014339 Arthrobacter arilaitensis Re117 9794538 YP_003916965.1 CDS AARI_17800 NC_014550.1 2015035 2015238 D match to PF00313: cold-shock DNA-binding domain. The so-called cold shock proteins are thought to help the cell to survive in temperatures lower than optimum growth temperature, by contrast with heat shock proteins, which help the cell to survive in temperatures greater than the optimum, possibly by condensation of the chromosome and organization of the prokaryotic nucleoid; cold shock protein 2015035..2015238 Arthrobacter arilaitensis Re117 9794539 YP_003916966.1 CDS istA NC_014550.1 2016529 2018085 D transposase of ISAar36, IS21 family, istA 2016529..2018085 Arthrobacter arilaitensis Re117 9793467 YP_003916967.1 CDS AARI_35280 NC_014550.1 2018406 2018702 D transposase of ISAar4, IS3 family, IS3 group, orfA 2018406..2018702 Arthrobacter arilaitensis Re117 9793468 YP_003916968.1 CDS AARI_35290 NC_014550.1 2018765 2019592 D transposase of ISAar4, IS3 family, IS3 group, orfB 2018765..2019592 Arthrobacter arilaitensis Re117 9793469 YP_003916969.1 CDS AARI_17810 NC_014550.1 2021220 2022491 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(2021220..2022491) Arthrobacter arilaitensis Re117 9793472 YP_003916970.1 CDS nrdF NC_014550.1 2023496 2024470 R ribonucleotide reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. It is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues); ribonucleoside-diphosphate reductase subunit beta complement(2023496..2024470) Arthrobacter arilaitensis Re117 9794541 YP_003916971.1 CDS nrdE NC_014550.1 2024685 2026823 R catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. It is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues); ribonucleoside-diphosphate reductase subunit alpha complement(2024685..2026823) Arthrobacter arilaitensis Re117 9794146 YP_003916972.1 CDS nrdI NC_014550.1 2026820 2027305 R probably involved in ribonucleotide reductase function. ribonucleotide reductases are enzymes that provide the precursors of DNA synthesis; NrdI protein complement(2026820..2027305) Arthrobacter arilaitensis Re117 9794144 YP_003916973.1 CDS nrdH NC_014550.1 2027347 2027577 R electron transport system for the ribonucleotide reductase system nrdEF; glutaredoxin electron transport component NrdH complement(2027347..2027577) Arthrobacter arilaitensis Re117 9794150 YP_003916974.1 CDS AARI_17860 NC_014550.1 2028091 2028828 R pyridoxal phosphate-dependent enzyme complement(2028091..2028828) Arthrobacter arilaitensis Re117 9794148 YP_003916975.1 CDS poxB NC_014550.1 2028904 2030628 R TPP-binding module. Catalyzes the formation of acetate from pyruvate (catalytic activity: pyruvate + ferricytochrome b1 + H2O = acetate + CO2 + ferrocytochrome b1); pyruvate dehydrogenase (cytochrome) complement(2028904..2030628) Arthrobacter arilaitensis Re117 9794542 YP_003916976.1 CDS AARI_17880 NC_014550.1 2030791 2031552 R pyridoxal phosphate-dependent enzyme complement(2030791..2031552) Arthrobacter arilaitensis Re117 9794214 YP_003916977.1 CDS AARI_17890 NC_014550.1 2031642 2032001 D hypothetical protein 2031642..2032001 Arthrobacter arilaitensis Re117 9794543 YP_003916978.1 CDS AARI_17900 NC_014550.1 2031998 2033059 R identified by match to PF00291: pyridoxal-phosphate dependent enzyme; pyridoxal phosphate-dependent enzyme complement(2031998..2033059) Arthrobacter arilaitensis Re117 9794544 YP_003916979.1 CDS AARI_17910 NC_014550.1 2033120 2033926 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.987) with cleavage site probability 0.704 between position 24 and 25. 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2033120..2033926 Arthrobacter arilaitensis Re117 9794545 YP_003916980.1 CDS AARI_17920 NC_014550.1 2034026 2034373 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 2034026..2034373 Arthrobacter arilaitensis Re117 9794546 YP_003916981.1 CDS AARI_17930 NC_014550.1 2034438 2036954 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.976 between position 27 and 28. 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(2034438..2036954) Arthrobacter arilaitensis Re117 9794547 YP_003916982.1 CDS AARI_17940 NC_014550.1 2037049 2037423 R hypothetical protein complement(2037049..2037423) Arthrobacter arilaitensis Re117 9794548 YP_003916983.1 CDS AARI_17950 NC_014550.1 2037454 2039136 D TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-2 (Drug RA2) family (TC 3.A.1.121.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family, ARE-subfamily (antibiotic resistance); drug resistance ATP-binding protein 2037454..2039136 Arthrobacter arilaitensis Re117 9794549 YP_003916984.1 CDS sdhA NC_014550.1 2039852 2041576 R the succinate dehydrogenase complex catalyses the interconversion of fumarate and succinate. It contains several subunits: a flavoprotein (SdhA), an iron-sulfur protein (SdhB), and membrane anchor proteins (SdhC and SdhD). Involved in the TCA cycle; succinate dehydrogenase flavoprotein subunit complement(2039852..2041576) Arthrobacter arilaitensis Re117 9794551 YP_003916985.1 CDS AARI_17980 NC_014550.1 2041770 2042576 D lysR family transcriptional regulator 2041770..2042576 Arthrobacter arilaitensis Re117 9794382 YP_003916986.1 CDS AARI_17990 NC_014550.1 2042665 2042904 D hypothetical protein 2042665..2042904 Arthrobacter arilaitensis Re117 9794552 YP_003916987.1 CDS AARI_18000 NC_014550.1 2042917 2043195 D hypothetical protein 2042917..2043195 Arthrobacter arilaitensis Re117 9794553 YP_003916988.1 CDS AARI_18010 NC_014550.1 2043192 2044181 R identified by match to protein family PF01370: NAD dependent epimerase/dehydratase family. This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; NAD dependent epimerase/dehydratase family protein complement(2043192..2044181) Arthrobacter arilaitensis Re117 9794554 YP_003916989.1 CDS AARI_18020 NC_014550.1 2044192 2045067 R hypothetical protein complement(2044192..2045067) Arthrobacter arilaitensis Re117 9794555 YP_003916990.1 CDS AARI_18030 NC_014550.1 2045131 2045988 R identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein complement(2045131..2045988) Arthrobacter arilaitensis Re117 9794556 YP_003916991.1 CDS AARI_18040 NC_014550.1 2046133 2046645 D identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator 2046133..2046645 Arthrobacter arilaitensis Re117 9794557 YP_003916992.1 CDS pat NC_014550.1 2046851 2047909 D may catalyze the transamination reaction in phenylalanine biosynthesis; phenylalanine aminotransferase 2046851..2047909 Arthrobacter arilaitensis Re117 9794558 YP_003916993.1 CDS AARI_18060 NC_014550.1 2047906 2049282 D amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family (TC 2.A.3.1.z); amino acid transporter 2047906..2049282 Arthrobacter arilaitensis Re117 9794178 YP_003916994.1 CDS AARI_18070 NC_014550.1 2049319 2049993 R hypothetical protein complement(2049319..2049993) Arthrobacter arilaitensis Re117 9794559 YP_003916995.1 CDS AARI_18080 NC_014550.1 2050005 2050622 R hypothetical protein complement(2050005..2050622) Arthrobacter arilaitensis Re117 9794560 YP_003916996.1 CDS AARI_18090 NC_014550.1 2050646 2051737 R CorA metal ion transporter (MIT) family protein (TC 1.A.35.y.z). Functionally characterized proteins from this family includes the Mg2+-Co2+-Ni2+ CorA permeases of Salmonella typhimurium and E. coli. Match to protein family PF01544; metal ion transporter complement(2050646..2051737) Arthrobacter arilaitensis Re117 9794561 YP_003916997.1 CDS AARI_18100 NC_014550.1 2051820 2053550 R identified by match to cd00085: HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins; HNH endonuclease domain-containing protein complement(2051820..2053550) Arthrobacter arilaitensis Re117 9794562 YP_003916998.1 CDS AARI_18110 NC_014550.1 2053805 2054185 R identified by match to protein family TIGR00090: iojap homolog; Iojap-like protein complement(2053805..2054185) Arthrobacter arilaitensis Re117 9793621 YP_003916999.1 CDS AARI_18120 NC_014550.1 2054243 2055730 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(2054243..2055730) Arthrobacter arilaitensis Re117 9794564 YP_003917000.1 CDS nadD NC_014550.1 2055813 2056418 R catalyses the following reaction: ATP + nicotinate ribonucleotide <=> diphosphate + deamido-NAD(+). Involved in the biosynthesis of NAD(+) and NADP(+); nicotinate-nucleotide adenylyltransferase complement(2055813..2056418) Arthrobacter arilaitensis Re117 9794565 YP_003917001.1 CDS AARI_18140 NC_014550.1 2056421 2056633 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(2056421..2056633) Arthrobacter arilaitensis Re117 9794129 YP_003917002.1 CDS proA NC_014550.1 2056752 2058038 R catalyzes the NADP-dependent reduction of L- glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. Involved in proline biosynthesis from glutamate; glutamate-5-semialdehyde dehydrogenase complement(2056752..2058038) Arthrobacter arilaitensis Re117 9794566 YP_003917003.1 CDS proB NC_014550.1 2058055 2059212 R catalyzes the ATP-dependent phosphorylation of L- glutamate into L-glutamate 5-phosphate. Involved in proline biosynthesis from glutamate; glutamate 5-kinase complement(2058055..2059212) Arthrobacter arilaitensis Re117 9794223 YP_003917004.1 CDS AARI_18170 NC_014550.1 2059216 2060805 R Obg proteins are among a large group of GTP binding proteins conserved from bacteria to humans. The E. coli homolog, ObgE is believed to function in ribosomal biogenesis; Obg family GTP-binding protein complement(2059216..2060805) Arthrobacter arilaitensis Re117 9794224 YP_003917005.1 CDS rpmA NC_014550.1 2060930 2061184 R L27 is a protein from the large (50S) subunit; 50S ribosomal protein L27 complement(2060930..2061184) Arthrobacter arilaitensis Re117 9794567 YP_003917006.1 CDS rplU NC_014550.1 2061233 2061541 R part of the 50S ribosomal subunit. Binds to 23S rRNA in the presence of protein L20; 50S ribosomal protein L21 complement(2061233..2061541) Arthrobacter arilaitensis Re117 9794333 YP_003917007.1 CDS AARI_18200 NC_014550.1 2061772 2064612 R match to PF10150: ribonuclease E/G family. Ribonuclease E and Ribonuclease G are related enzymes that cleave a wide variety of RNAs. In E. coli, both RNase E and RNase G have been shown to play a role in the maturation of the 5 end of 16S RNA; ribonuclease complement(2061772..2064612) Arthrobacter arilaitensis Re117 9794328 YP_003917008.1 CDS AARI_18210 NC_014550.1 2065220 2065843 D 5 transmembrane helices predicted by TMHMM2.0. Match to IPR012932: vitamin K epoxide reductase; hypothetical protein 2065220..2065843 Arthrobacter arilaitensis Re117 9794568 YP_003917009.1 CDS AARI_18220 NC_014550.1 2066112 2066696 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2066112..2066696 Arthrobacter arilaitensis Re117 9794569 YP_003917010.1 CDS AARI_18230 NC_014550.1 2066920 2068209 D 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2066920..2068209 Arthrobacter arilaitensis Re117 9794570 YP_003917011.1 CDS AARI_18240 NC_014550.1 2068562 2068768 D hypothetical protein 2068562..2068768 Arthrobacter arilaitensis Re117 9794571 YP_003917012.1 CDS ndk NC_014550.1 2068832 2069248 R catalyses the following reaction: ATP + nucleoside diphosphate <=> ADP + nucleoside triphosphate. Required for the synthesis of nucleoside triphosphates other than ATP; nucleoside-diphosphate kinase complement(2068832..2069248) Arthrobacter arilaitensis Re117 9794572 YP_003917013.1 CDS AARI_18260 NC_014550.1 2069289 2069723 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.872) with cleavage site probability 0.380 between position 52 and 53. 2 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(2069289..2069723) Arthrobacter arilaitensis Re117 9794137 YP_003917014.1 CDS folC NC_014550.1 2069723 2071075 R leds to conversion of folates to polyglutamate derivatives. It preferes 5,10-methylenetetrahydrofolate, rather than 10-formyltetrahydrofolate as folate substrate: ATP + tetrahydropteroyl-(gamma-Glu)(n) + L-glutamate <=> ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1); tetrahydrofolate synthase complement(2069723..2071075) Arthrobacter arilaitensis Re117 9794573 YP_003917015.1 CDS ileS NC_014550.1 2071075 2074335 R isoleucine-tRNA ligase complement(2071075..2074335) Arthrobacter arilaitensis Re117 9793858 YP_003917016.1 CDS AARI_18290 NC_014550.1 2074785 2075339 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2074785..2075339 Arthrobacter arilaitensis Re117 9794001 YP_003917017.1 CDS AARI_18300 NC_014550.1 2075390 2076637 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 5 transmembrane helices predicted by TMHMM2.0; signal transduction histidine kinase 2075390..2076637 Arthrobacter arilaitensis Re117 9794574 YP_003917018.1 CDS AARI_18310 NC_014550.1 2076634 2077251 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 2076634..2077251 Arthrobacter arilaitensis Re117 9794575 YP_003917019.1 CDS AARI_18320 NC_014550.1 2077364 2079466 D Resistance-Nodulation-Cell Division (RND) superfamily (TC 2.A.6.y.z). Match to PS50156: sterol- sensing domain. In bacteria, this domain is found in a number of drug resistance proteins; drug exporter of the RND superfamily 2077364..2079466 Arthrobacter arilaitensis Re117 9794576 YP_003917020.1 CDS AARI_18330 NC_014550.1 2079471 2079902 D 4 transmembranes helice predicted by TMHMM2.0; hypothetical protein 2079471..2079902 Arthrobacter arilaitensis Re117 9794577 YP_003917021.1 CDS AARI_18340 NC_014550.1 2080080 2081318 D DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit epsilon 2080080..2081318 Arthrobacter arilaitensis Re117 9794578 YP_003917022.1 CDS AARI_18350 NC_014550.1 2081407 2082861 R sulfite reductase catalyzes the reduction of sulfite to sulphide. Involved in the sulfate assimilation pathway; sulfite reductase (NADPH) complement(2081407..2082861) Arthrobacter arilaitensis Re117 9794579 YP_003917023.1 CDS cobA NC_014550.1 2082879 2083658 R catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2 (dihydrosirohydrochlorin): (1) S- adenosyl-L-methionine + uroporphyrinogen III <=> S- adenosyl-L-homocysteine + precorrin-1, (2) S-adenosyl-L- methionine + precorrin-1 <=> S-adenosyl-L-homocysteine + precorrin-2; uroporphyrinogen-III C-methyltransferase complement(2082879..2083658) Arthrobacter arilaitensis Re117 9794580 YP_003917024.1 CDS AARI_18370 NC_014550.1 2083651 2084508 R TCDB: ATP-binding cassette (ABC) superfamily, taurine uptake transporter (TauT) family (TC 3.A.1.17.z). ABCISSE: ABC transporter, permease (IM), OTCN-family (osmoprotectants, taurine, cyanate and nitrate), aliphatic sulfonates import. Part of an ABC transporter complex involved in aliphatic sulfonates import; aliphatic sulfonates ABC transporter inner membrane subunit complement(2083651..2084508) Arthrobacter arilaitensis Re117 9793751 YP_003917025.1 CDS AARI_18380 NC_014550.1 2084480 2085223 R TCDB: ATP-binding cassette (ABC) superfamily, taurine uptake transporter (TauT) family (TC 3.A.1.17.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OTCN- family (osmoprotectants, taurine, cyanate and nitrate), aliphatic sulfonates import. Part of an ABC transporter complex involved in aliphatic sulfonates import; aliphatic sulfonates ABC transporter ATP-binding subunit complement(2084480..2085223) Arthrobacter arilaitensis Re117 9794581 YP_003917026.1 CDS AARI_18390 NC_014550.1 2085223 2086320 R TCDB: ATP-binding cassette (ABC) superfamily, taurine uptake transporter (TauT) family (TC 3.A.1.17.z). ABCISSE: ABC transporter, binding protein (BP), OTCN- family (osmoprotectants, taurine, cyanate and nitrate), aliphatic sulfonates import. Part of an ABC transporter complex involved in aliphatic sulfonates import; aliphatic sulfonates ABC transporter substrate-binding protein complement(2085223..2086320) Arthrobacter arilaitensis Re117 9794582 YP_003917027.1 CDS cysN NC_014550.1 2086307 2087602 R catalyses the formation of diphosphate and adenylyl sulphate from ATP and sulphate. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism; sulfate adenylyltransferase large subunit complement(2086307..2087602) Arthrobacter arilaitensis Re117 9794583 YP_003917028.1 CDS cysD NC_014550.1 2087604 2088527 R catalyses the formation of diphosphate and adenylyl sulphate from ATP and sulphate. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism; sulfate adenylyltransferase small subunit complement(2087604..2088527) Arthrobacter arilaitensis Re117 9793782 YP_003917029.1 CDS cysH NC_014550.1 2088539 2089261 R identified by similarity to protein SP:P65668 (Mycobacterium tuberculosis). Involved in sulfate assimilation. Catalyzes the following reaction: adenylyl sulfate (APS) + reduced acceptor => AMP + sulfite + acceptor; adenylyl-sulfate reductase complement(2088539..2089261) Arthrobacter arilaitensis Re117 9793777 YP_003917030.1 CDS sir NC_014550.1 2089258 2090958 R catalyzes the reduction of sulfite to sulphide. Involved in the sulfate assimilation pathway; sulfite reductase (ferredoxin) complement(2089258..2090958) Arthrobacter arilaitensis Re117 9793779 YP_003917031.1 CDS AARI_18440 NC_014550.1 2091026 2091766 R identified by match to protein family PF01903. The function of CbiX is uncertain, however it is found in cobalamin biosynthesis operons and so may have a related function. Some CbiX proteins contain a striking histidine- rich region at their C-terminus, which suggests that it might be involved in metal chelation; CbiX family protein complement(2091026..2091766) Arthrobacter arilaitensis Re117 9794396 YP_003917032.1 CDS AARI_18450 NC_014550.1 2091797 2092561 R identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein complement(2091797..2092561) Arthrobacter arilaitensis Re117 9794584 YP_003917033.1 CDS valS NC_014550.1 2092766 2095384 D valine-tRNA ligase 2092766..2095384 Arthrobacter arilaitensis Re117 9794585 YP_003917034.1 CDS AARI_18470 NC_014550.1 2095446 2095634 R hypothetical protein complement(2095446..2095634) Arthrobacter arilaitensis Re117 9794500 YP_003917035.1 CDS AARI_18480 NC_014550.1 2095704 2096711 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 1.000 between position 39 and 40; hypothetical protein complement(2095704..2096711) Arthrobacter arilaitensis Re117 9794586 YP_003917036.1 CDS AARI_35320 NC_014550.1 2096902 2097972 R transposase of ISAar1, IS1595 family, ISSod11 group complement(2096902..2097972) Arthrobacter arilaitensis Re117 9794587 YP_003917037.1 CDS AARI_35330 NC_014550.1 2098401 2099708 R transposase of ISAar19, ISL3 family complement(2098401..2099708) Arthrobacter arilaitensis Re117 9793473 YP_003917038.1 CDS AARI_18490 NC_014550.1 2100251 2100859 R hypothetical protein complement(2100251..2100859) Arthrobacter arilaitensis Re117 9793474 YP_003917039.1 CDS clpX NC_014550.1 2100905 2102197 R ATP-dependent Clp protease ATP-binding subunit ClpX complement(2100905..2102197) Arthrobacter arilaitensis Re117 9794588 YP_003917040.1 CDS clpP NC_014550.1 2102365 2103024 R Clp displays ATP-dependent endopeptidase activity. It contains subunits of two types, ClpP, with peptidase activity, and ClpA or ClpX, with ATPase activity; ATP-dependent Clp protease proteolytic subunit ClpP complement(2102365..2103024) Arthrobacter arilaitensis Re117 9793743 YP_003917041.1 CDS clpP NC_014550.1 2103072 2103692 R Clp displays ATP-dependent endopeptidase activity. It contains subunits of two types, ClpP, with peptidase activity, and ClpA or ClpX, with ATPase activity; ATP-dependent Clp protease proteolytic subunit ClpP complement(2103072..2103692) Arthrobacter arilaitensis Re117 9793740 YP_003917042.1 CDS tig NC_014550.1 2103916 2105247 R the trigger factor is found in several prokaryotes, and is involved in protein export. It is a ribosome- associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. It acts as a chaperone by maintaining the newly synthesised protein in an open conformation. The central domain of trigger factor has peptidyl-prolyl cis/trans isomerase activity (EC 5.2.1. 8); trigger factor complement(2103916..2105247) Arthrobacter arilaitensis Re117 9793741 YP_003917043.1 CDS AARI_18540 NC_014550.1 2106880 2107848 R involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; DNA glycosylase complement(2106880..2107848) Arthrobacter arilaitensis Re117 9793625 YP_003917044.1 CDS rpi NC_014550.1 2107851 2108324 R catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate. Involved in the pentose phosphate pathway; ribose-5-phosphate isomerase complement(2107851..2108324) Arthrobacter arilaitensis Re117 9794589 YP_003917045.1 CDS pepN NC_014550.1 2108614 2111154 D catalyzes the removal of single amino acids from the amino terminus of small peptides; membrane alanyl aminopeptidase 2108614..2111154 Arthrobacter arilaitensis Re117 9794309 YP_003917046.1 CDS AARI_35340 NC_014550.1 2111312 2112667 R transposase of ISAar28, IS481 family complement(2111312..2112667) Arthrobacter arilaitensis Re117 9794194 YP_003917047.1 CDS AARI_18570 NC_014550.1 2112856 2113332 D identified by match to protein family PF02566: OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress-induced protein found in Escherichia coli. This family also contains an organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation; OsmC-like protein 2112856..2113332 Arthrobacter arilaitensis Re117 9793475 YP_003917048.1 CDS AARI_18580 NC_014550.1 2113345 2113863 D identified by match to protein family PF01152: bacterial-like globin. Globins are heme-containing proteins involved in binding and/or transporting oxygen; bacterial globin-like protein 2113345..2113863 Arthrobacter arilaitensis Re117 9794590 YP_003917049.1 CDS AARI_18590 NC_014550.1 2113920 2114579 R hypothetical protein complement(2113920..2114579) Arthrobacter arilaitensis Re117 9794591 YP_003917050.1 CDS tesB NC_014550.1 2114755 2115648 D identified by similarity to protein SP:P0AGG2 (Escherichia coli). Can hydrolyze a broad range of acyl- CoA thioesters. Its physiological function is not known; acyl-CoA thioesterase II 2114755..2115648 Arthrobacter arilaitensis Re117 9794592 YP_003917051.1 CDS AARI_18610 NC_014550.1 2115682 2117421 R match to PF03473. The MOSC (MOCO sulfurase C- terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. The MOSC domain is predicted to be a sulfur- carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters; MOSC domain-containing protein complement(2115682..2117421) Arthrobacter arilaitensis Re117 9794436 YP_003917052.1 CDS AARI_18620 NC_014550.1 2117530 2118036 R identified by match to protein family TIGR01950. SoxR is a MerR-family homodimeric transcription factor with a 2Fe-2S cluster in each monomer. The motif CIGCGCxxxxxC is conserved. Oxidation of the iron-sulfur cluster activates SoxR. The physiological role in E. coli is response to oxidative stress. It is activated by superoxide, singlet oxygen, nitric oxide (NO), and hydrogen peroxide. In E. coli, SoxR increases expression of transcription factor SoxS; different downstream targets may exist in other species; redox-sensitive transcriptional regulator SoxR complement(2117530..2118036) Arthrobacter arilaitensis Re117 9794593 YP_003917053.1 CDS AARI_18630 NC_014550.1 2118170 2118676 D identified by match to PF01613; flavin reductase-like domain protein 2118170..2118676 Arthrobacter arilaitensis Re117 9794594 YP_003917054.1 CDS AARI_18640 NC_014550.1 2118745 2120427 R TCDB: ATP-binding cassette (ABC) superfamily, () drug resistance ATPase-2 (Drug RA2) family (TC 3.A.1.121.z). ABCISSE: fused ATP-binding protein (ABC2), ART-family, ARE-subfamily (antibiotic resistance); drug resistance ATP-binding protein complement(2118745..2120427) Arthrobacter arilaitensis Re117 9794595 YP_003917055.1 CDS ssb NC_014550.1 2120541 2120990 R this protein is essential for replication of the chromosome. It is also involved in DNA recombination and repair; single-stranded DNA-binding protein complement(2120541..2120990) Arthrobacter arilaitensis Re117 9794596 YP_003917056.1 CDS AARI_18660 NC_014550.1 2121081 2121980 R hypothetical protein complement(2121081..2121980) Arthrobacter arilaitensis Re117 9794404 YP_003917057.1 CDS AARI_35350 NC_014550.1 2122145 2123581 D transposase of ISAar8, IS1380 family 2122145..2123581 Arthrobacter arilaitensis Re117 9794597 YP_003917058.1 CDS AARI_18670 NC_014550.1 2124030 2125712 R identified by match to PF00890. This family includes members that bind FAD such as the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase; FAD binding domain-containing protein complement(2124030..2125712) Arthrobacter arilaitensis Re117 9793626 YP_003917059.1 CDS AARI_18680 NC_014550.1 2126004 2127221 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter 2126004..2127221 Arthrobacter arilaitensis Re117 9794598 YP_003917060.1 CDS AARI_18690 NC_014550.1 2127218 2127664 R identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator complement(2127218..2127664) Arthrobacter arilaitensis Re117 9794599 YP_003917061.1 CDS AARI_18700 NC_014550.1 2127821 2128537 D resistance to homoSer/Thr (RhtB) family protein (TC 2.A.76.y.z). The family includes homoserine, threonine and leucine efflux proteins. The transport reaction presumably catalyzed by members of the RhtB family is: amino acid (in) + nH+ (out) <--> amino acid (out) + nH+ (in); RHBT family amino acid transporter 2127821..2128537 Arthrobacter arilaitensis Re117 9794600 YP_003917062.1 CDS AARI_18710 NC_014550.1 2128685 2129374 D TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC), CBY-family (Cobalt uptake, unknown), Y179- subfamily (CBU-like systems). The function of CBU-like systems is unknown; ABC transporter ATP-binding subunit 2128685..2129374 Arthrobacter arilaitensis Re117 9794601 YP_003917063.1 CDS AARI_18720 NC_014550.1 2129371 2129976 D TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM), CBY-family (Cobalt uptake, unknown), Y179-subfamily (CBU-like systems). The function of CBU-like systems is unknown; ABC transporter inner membrane subunit 2129371..2129976 Arthrobacter arilaitensis Re117 9794602 YP_003917064.1 CDS AARI_18730 NC_014550.1 2130022 2130603 D TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM), CBY-family (Cobalt uptake, unknown), Y179-subfamily (CBU-like systems). The function of CBU-like systems is unknown; ABC transporter inner membrane subunit 2130022..2130603 Arthrobacter arilaitensis Re117 9794603 YP_003917065.1 CDS AARI_18740 NC_014550.1 2130608 2132047 D match to protein family PF00501. This family of enzymes includes luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely- related synthetases; fatty-acid--Co-A ligase 2130608..2132047 Arthrobacter arilaitensis Re117 9794604 YP_003917066.1 CDS AARI_18750 NC_014550.1 2132044 2133222 D acetyl-CoA C-acyltransferase (also named 3-ketoacyl- CoA thiolase or thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation; acetyl-CoA C-acyltransferase 2132044..2133222 Arthrobacter arilaitensis Re117 9794605 YP_003917067.1 CDS AARI_18760 NC_014550.1 2133371 2133715 R hypothetical protein complement(2133371..2133715) Arthrobacter arilaitensis Re117 9794606 YP_003917068.1 CDS sufC NC_014550.1 2133726 2134484 R the SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet; FeS assembly ATPase SufC complement(2133726..2134484) Arthrobacter arilaitensis Re117 9794607 YP_003917069.1 CDS sufD NC_014550.1 2134545 2135825 R the SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet; FeS assembly protein SufD complement(2134545..2135825) Arthrobacter arilaitensis Re117 9794414 YP_003917070.1 CDS sufB NC_014550.1 2135828 2137288 R the SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet; FeS assembly protein SufB complement(2135828..2137288) Arthrobacter arilaitensis Re117 9794415 YP_003917071.1 CDS AARI_18800 NC_014550.1 2137285 2138070 R transcriptional regulator complement(2137285..2138070) Arthrobacter arilaitensis Re117 9794413 YP_003917072.1 CDS AARI_18810 NC_014550.1 2138262 2139215 D TCDB: ATP-binding cassette (ABC) superfamily, drug exporter-1 (DrugE1) family (TC 3.A.1.105.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), DRA-family (Drug and Antibiotic resistance), DRR-subfamily (Polyketide drug resistance). The typical organization of DRR systems consists of 1 ABC transporter (ABC) and 1 or 2 permeases (IM). Possible function in drug efflux; ABC drug resistance transporter, ATP-binding subunit 2138262..2139215 Arthrobacter arilaitensis Re117 9794608 YP_003917073.1 CDS AARI_18820 NC_014550.1 2139212 2139976 D TCDB: ATP-binding cassette (ABC) superfamily, drug exporter-1 (DrugE1) family (TC 3.A.1.105.z). ABCISSE: ABC transporter, permease (IM), DRA-family (Drug and Antibiotic resistance), DRR-subfamily (Polyketide drug resistance). The typical organization of DRR systems consists of 1 ABC transporter (ABC) and 1 or 2 permeases (IM). Possible function in drug efflux; ABC drug resistance transporter, inner membrane subunit 2139212..2139976 Arthrobacter arilaitensis Re117 9794609 YP_003917074.1 CDS AARI_18830 NC_014550.1 2140007 2140945 D identified by match to protein family PF02628. One member of this family, CtaA, is required for cytochrome aa3 biosynthesis in Bacillus subtilis; cytochrome oxidase assembly protein 2140007..2140945 Arthrobacter arilaitensis Re117 9794610 YP_003917075.1 CDS AARI_18840 NC_014550.1 2141014 2141961 R 6 transmembranes helices predicted by TMHMM2.0; hypothetical protein complement(2141014..2141961) Arthrobacter arilaitensis Re117 9794611 YP_003917076.1 CDS AARI_18850 NC_014550.1 2141945 2142295 R identified by match to protein family PF03551; PadR-like family transcriptional regulator complement(2141945..2142295) Arthrobacter arilaitensis Re117 9794612 YP_003917077.1 CDS cyoE NC_014550.1 2142509 2143411 R converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; protoheme IX farnesyltransferase complement(2142509..2143411) Arthrobacter arilaitensis Re117 9794613 YP_003917078.1 CDS tkt NC_014550.1 2144269 2146383 D catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to ribose 5- phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. The second reaction catalyzed by transketolase involves the transfer of a 2-carbon fragment from D-xylulose 5-phosphate to the aldose D- erythrose-4-phosphate, affording fructose-6-phosphate and glyceraldehyde 3-phosphate; transketolase 2144269..2146383 Arthrobacter arilaitensis Re117 9793774 YP_003917079.1 CDS tal NC_014550.1 2146402 2147505 D catalyzes the reversible formation of D-erythrose 4- phosphate and D-fructose 6-phosphate from sedoheptulose 7- phosphate and D-glyceraldehyde 3-phosphate; transaldolase 2146402..2147505 Arthrobacter arilaitensis Re117 9794455 YP_003917080.1 CDS pgi NC_014550.1 2147506 2149080 D catalyzes the reversible isomerization of glucose-6- phosphate to fructose-6-phosphate. Also catalyzes the anomerization of D-glucose-6-phosphate; glucose-6-phosphate isomerase 2147506..2149080 Arthrobacter arilaitensis Re117 9794423 YP_003917081.1 CDS zwf NC_014550.1 2149087 2150607 D catalyzes the first step in the pentose phosphate pathway, the reduction of glucose-6-phosphate to gluconolactone-6-phosphate; glucose-6-phosphate 1-dehydrogenase 2149087..2150607 Arthrobacter arilaitensis Re117 9794197 YP_003917082.1 CDS opcA NC_014550.1 2150604 2151545 D subunit of glucose-6-phosphate 1- dehydrogenase; OpcA protein 2150604..2151545 Arthrobacter arilaitensis Re117 9794518 YP_003917083.1 CDS pgl NC_014550.1 2151535 2152275 D involved in the pentose phosphate pathway. Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate; 6-phosphogluconolactonase 2151535..2152275 Arthrobacter arilaitensis Re117 9794157 YP_003917084.1 CDS dao NC_014550.1 2152357 2153322 D catalyzes the oxidative deamination of D-amino acids to the corresponding keto acids, producing ammonia and hydrogen peroxide as by-products; D-amino-acid oxidase 2152357..2153322 Arthrobacter arilaitensis Re117 9794199 YP_003917085.1 CDS glgP NC_014550.1 2153669 2156107 D the members of this family catalyse the formation of glucose 1-phosphate from one of the following polyglucoses: glycogen, starch, glucan or maltodextrin; phosphorylase 2153669..2156107 Arthrobacter arilaitensis Re117 9793787 YP_003917086.1 CDS glgB NC_014550.1 2156218 2158410 D catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage, yielding a non-reducing end oligosaccharide chain and subsequent attachment to the alpha-1,6 position; 1,4-alpha-glucan branching enzyme 2156218..2158410 Arthrobacter arilaitensis Re117 9793902 YP_003917087.1 CDS glgC NC_014550.1 2158407 2159741 D catalyzes an important step in the biosynthesis of alpha 1,4-glucans (glycogen or starch) in bacteria and plants: synthesis of the activated glucosyl donor, ADP- glucose, from glucose-1-phosphate and ATP; glucose-1-phosphate adenylyltransferase 2158407..2159741 Arthrobacter arilaitensis Re117 9793900 YP_003917088.1 CDS glgA NC_014550.1 2159748 2161196 D involved in glycogen synthesis from ADP-glucose; bacterial glycogen synthase 2159748..2161196 Arthrobacter arilaitensis Re117 9793901 YP_003917089.1 CDS secG NC_014550.1 2163392 2163643 R identified by match to protein family PF03840. The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF); protein-export membrane protein SecG complement(2163392..2163643) Arthrobacter arilaitensis Re117 9794615 YP_003917090.1 CDS tpiA NC_014550.1 2163666 2164481 R catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate; triosephosphate isomerase complement(2163666..2164481) Arthrobacter arilaitensis Re117 9794390 YP_003917091.1 CDS pgk NC_014550.1 2164485 2165714 R catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3- phosphoglycerate; phosphoglycerate kinase complement(2164485..2165714) Arthrobacter arilaitensis Re117 9794458 YP_003917092.1 CDS gap NC_014550.1 2165731 2166738 R catalyses the reversible oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3- diphospho-glycerate; glyceraldehyde-3-phosphate dehydrogenase complement(2165731..2166738) Arthrobacter arilaitensis Re117 9794198 YP_003917093.1 CDS sodA NC_014550.1 2166923 2167552 R catalyses the conversion of superoxide radicals to hydrogen peroxide and molecular oxygen; superoxide dismutase complement(2166923..2167552) Arthrobacter arilaitensis Re117 9793885 YP_003917094.1 CDS AARI_19050 NC_014550.1 2167613 2168593 R hypothetical protein complement(2167613..2168593) Arthrobacter arilaitensis Re117 9794399 YP_003917095.1 CDS AARI_19060 NC_014550.1 2168621 2169646 R match to PF1933: uncharacterised protein family UPF0052; hypothetical protein complement(2168621..2169646) Arthrobacter arilaitensis Re117 9794616 YP_003917096.1 CDS AARI_19070 NC_014550.1 2169652 2170545 R match to PF1933. This family contains an ATP- binding site and could be an ATPase; P-loop ATPase protein complement(2169652..2170545) Arthrobacter arilaitensis Re117 9794617 YP_003917097.1 CDS uvrC NC_014550.1 2170555 2172498 R excinuclease ABC catalyses nucleotide excision repair in a multi-step process; excinuclease ABC subunit C complement(2170555..2172498) Arthrobacter arilaitensis Re117 9794618 YP_003917098.1 CDS AARI_19090 NC_014550.1 2172502 2173173 R 1-acylglycerol-3-phosphate O-acyltransferase catalyzes the following reaction: Acyl-CoA + 1-acyl-sn- glycerol 3-phosphate <=> CoA + 1,2-diacyl-sn-glycerol 3- phosphate. It is involved in phospholipid biosynthesis; 1-acylglycerol-3-phosphate O-acyltransferase complement(2172502..2173173) Arthrobacter arilaitensis Re117 9794499 YP_003917099.1 CDS AARI_19100 NC_014550.1 2173174 2173863 R identified by match to PF00702. This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases; haloacid dehalogenase complement(2173174..2173863) Arthrobacter arilaitensis Re117 9794619 YP_003917100.1 CDS uvrA NC_014550.1 2173965 2176793 R excinuclease ABC catalyses nucleotide excision repair in a multi-step process; excinuclease ABC subunit A complement(2173965..2176793) Arthrobacter arilaitensis Re117 9794620 YP_003917101.1 CDS AARI_19120 NC_014550.1 2176974 2177351 R transcriptional regulator complement(2176974..2177351) Arthrobacter arilaitensis Re117 9794496 YP_003917102.1 CDS AARI_19130 NC_014550.1 2177434 2178087 D identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase 2177434..2178087 Arthrobacter arilaitensis Re117 9794621 YP_003917103.1 CDS tam NC_014550.1 2178162 2178953 R catalyzes the monomethyl esterification of trans- aconitate and related compounds. Possible role in detoxifying trans-aconitate; trans-aconitate 2-methyltransferase complement(2178162..2178953) Arthrobacter arilaitensis Re117 9794622 YP_003917104.1 CDS AARI_19150 NC_014550.1 2179031 2181562 D possible DNA or RNA helicase; ATP-dependent helicase 2179031..2181562 Arthrobacter arilaitensis Re117 9794424 YP_003917105.1 CDS AARI_19160 NC_014550.1 2181565 2182020 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 2181565..2182020 Arthrobacter arilaitensis Re117 9794623 YP_003917106.1 CDS AARI_19170 NC_014550.1 2182093 2182284 D hypothetical protein 2182093..2182284 Arthrobacter arilaitensis Re117 9794624 YP_003917107.1 CDS AARI_19180 NC_014550.1 2182300 2183073 R hypothetical protein complement(2182300..2183073) Arthrobacter arilaitensis Re117 9794625 YP_003917108.1 CDS AARI_35360 NC_014550.1 2183180 2184259 R transposase of ISAar29, IS110 family complement(2183180..2184259) Arthrobacter arilaitensis Re117 9794626 YP_003917109.1 CDS AARI_19190 NC_014550.1 2184378 2184632 R hypothetical protein complement(2184378..2184632) Arthrobacter arilaitensis Re117 9793477 YP_003917110.1 CDS AARI_19200 NC_014550.1 2184684 2185436 R identified by match to PF04307: predicted membrane- bound metal-dependent hydrolase (DUF457); membrane-bound metal-dependent hydrolase complement(2184684..2185436) Arthrobacter arilaitensis Re117 9794627 YP_003917111.1 CDS AARI_19210 NC_014550.1 2185499 2185987 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2185499..2185987 Arthrobacter arilaitensis Re117 9794628 YP_003917112.1 CDS AARI_19220 NC_014550.1 2185987 2187270 D releases N-terminal proline from a peptide; prolyl aminopeptidase 2185987..2187270 Arthrobacter arilaitensis Re117 9794629 YP_003917113.1 CDS AARI_19230 NC_014550.1 2187354 2187806 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(2187354..2187806) Arthrobacter arilaitensis Re117 9794630 YP_003917114.1 CDS AARI_19240 NC_014550.1 2187910 2189049 R match to PF0371: TerC, Integral membrane protein TerC family. 9 transmembranes helices predicted by TMHMM2. 0; hypothetical protein complement(2187910..2189049) Arthrobacter arilaitensis Re117 9794631 YP_003917115.1 CDS uvrB NC_014550.1 2189175 2191262 R excinuclease ABC catalyses nucleotide excision repair in a multi-step process; excinuclease ABC subunit B complement(2189175..2191262) Arthrobacter arilaitensis Re117 9794632 YP_003917116.1 CDS AARI_19260 NC_014550.1 2191336 2191584 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2191336..2191584) Arthrobacter arilaitensis Re117 9794498 YP_003917117.1 CDS coaE NC_014550.1 2191587 2192183 R catalyzes the phosphorylation of the 3-hydroxyl group of dephosphocoenzyme A to form coenzyme A: ATP + dephospho-CoA = ADP + CoA; dephospho-CoA kinase complement(2191587..2192183) Arthrobacter arilaitensis Re117 9794633 YP_003917118.1 CDS AARI_19280 NC_014550.1 2192209 2192883 D match to PF01205: uncharacterized protein family UPF0029; hypothetical protein 2192209..2192883 Arthrobacter arilaitensis Re117 9793750 YP_003917119.1 CDS AARI_19290 NC_014550.1 2192880 2194091 D match to protein domain PF05175. This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases; methyltransferase 2192880..2194091 Arthrobacter arilaitensis Re117 9794634 YP_003917120.1 CDS AARI_19300 NC_014550.1 2194153 2195799 D hypothetical protein 2194153..2195799 Arthrobacter arilaitensis Re117 9794635 YP_003917121.1 CDS AARI_19310 NC_014550.1 2195827 2197137 R 6 transmembranes helices predicted by TMHMM2.0; hypothetical protein complement(2195827..2197137) Arthrobacter arilaitensis Re117 9794636 YP_003917122.1 CDS rpsA NC_014550.1 2197385 2198860 R binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence; 30S ribosomal protein S1 complement(2197385..2198860) Arthrobacter arilaitensis Re117 9794637 YP_003917123.1 CDS AARI_19330 NC_014550.1 2199077 2200390 R hypothetical protein complement(2199077..2200390) Arthrobacter arilaitensis Re117 9794348 YP_003917124.1 CDS AARI_19340 NC_014550.1 2200459 2201361 R match to protein domain PF01522. This domain is found in polysaccharide deacetylase. This family of polysaccharide deacetylases includes NodB, which is a chitooligosaccharide deacetylase. It also includes chitin deacetylase from yeast and endoxylanases which hydrolyses glucosidic bonds in xylan; polysaccharide deacetylase domain-containing protein complement(2200459..2201361) Arthrobacter arilaitensis Re117 9794638 YP_003917125.1 CDS polA NC_014550.1 2201470 2204082 R DNA polymerase I complement(2201470..2204082) Arthrobacter arilaitensis Re117 9794639 YP_003917126.1 CDS AARI_19360 NC_014550.1 2204168 2204653 D match to protein domain PF03061: thioesterase superfamily; thioesterase family domain-containing protein 2204168..2204653 Arthrobacter arilaitensis Re117 9794213 YP_003917127.1 CDS AARI_19370 NC_014550.1 2204747 2205292 R match to protein domain PF01872. This domain is found in the C-terminus of the bifunctional deaminase- reductase in combination with PF00383 as well as in isolation in some archaebacterial proteins; RibD domain-containing protein complement(2204747..2205292) Arthrobacter arilaitensis Re117 9794640 YP_003917128.1 CDS AARI_19380 NC_014550.1 2205386 2205634 R 2 transmembranes helices predicted by TMHMM2.0; hypothetical protein complement(2205386..2205634) Arthrobacter arilaitensis Re117 9794641 YP_003917129.1 CDS pit NC_014550.1 2205631 2206863 R inorganic phosphate transporter (PiT) family (TC 2. A.20.y.z); low-affinity inorganic phosphate transporter complement(2205631..2206863) Arthrobacter arilaitensis Re117 9794642 YP_003917130.1 CDS AARI_19400 NC_014550.1 2207163 2207780 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. Match to PF03861: ANTAR domain. ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; two-component system response regulator complement(2207163..2207780) Arthrobacter arilaitensis Re117 9794207 YP_003917131.1 CDS pyk NC_014550.1 2208228 2209751 R catalyses the conversion of phosphoenolpyruvate to pyruvate with the concomitant phosphorylation of ADP to ATP; pyruvate kinase complement(2208228..2209751) Arthrobacter arilaitensis Re117 9793627 YP_003917132.1 CDS gltD NC_014550.1 2209826 2211295 R glutamate synthase participates in the ammonia assimilation process by catalyzing the formation of glutamate from glutamine and 2-oxoglutarate; glutamate synthase (NADPH) subunit beta complement(2209826..2211295) Arthrobacter arilaitensis Re117 9794263 YP_003917133.1 CDS gltB NC_014550.1 2211288 2215907 R glutamate synthase participates in the ammonia assimilation process by catalyzing the formation of glutamate from glutamine and 2-oxoglutarate; glutamate synthase (NADPH) subunit alpha complement(2211288..2215907) Arthrobacter arilaitensis Re117 9793919 YP_003917134.1 CDS lgt NC_014550.1 2216481 2217521 R catalyzes the first step in lipoprotein biogenesis. It transfers the n-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins; prolipoprotein diacylglyceryl transferase complement(2216481..2217521) Arthrobacter arilaitensis Re117 9793918 YP_003917135.1 CDS trpA NC_014550.1 2217521 2218303 R tryptophan synthase catalyzes the last step in the biosynthesis of tryptophan: the conversion of indoleglycerol phosphate and serine, to tryptophan and glyceraldehyde 3- phosphate. Also catalyzes the conversion of serine and indole into tryptophan and water, and of indoleglycerol phosphate into indole and glyceraldehyde phosphate; tryptophan synthase subunit alpha complement(2217521..2218303) Arthrobacter arilaitensis Re117 9794037 YP_003917136.1 CDS trpB NC_014550.1 2218304 2219635 R tryptophan synthase catalyzes the last step in the biosynthesis of tryptophan: the conversion of indoleglycerol phosphate and serine, to tryptophan and glyceraldehyde 3- phosphate. Also catalyzes the conversion of serine and indole into tryptophan and water, and of indoleglycerol phosphate into indole and glyceraldehyde phosphate; tryptophan synthase subunit beta complement(2218304..2219635) Arthrobacter arilaitensis Re117 9794466 YP_003917137.1 CDS trpC NC_014550.1 2219744 2220568 R catalyzes the fourth step in the biosynthesis of tryptophan: the ring closure of 1-(2-carboxy-phenylamino)- 1-deoxyribulose into indol-3-glycerol-phosphate; indole-3-glycerol-phosphate synthase complement(2219744..2220568) Arthrobacter arilaitensis Re117 9794467 YP_003917138.1 CDS AARI_19480 NC_014550.1 2220570 2220818 R 2 transmembranes helices predicted by TMHMM2.0; hypothetical protein complement(2220570..2220818) Arthrobacter arilaitensis Re117 9794468 YP_003917139.1 CDS AARI_19490 NC_014550.1 2220976 2221566 R hypothetical protein complement(2220976..2221566) Arthrobacter arilaitensis Re117 9794644 YP_003917140.1 CDS trpE NC_014550.1 2221563 2223134 R anthranilate synthase is the first enzyme in the branch pathway in tryptophane biosynthesis. It catalyzes the biosynthesis of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(2221563..2223134) Arthrobacter arilaitensis Re117 9794645 YP_003917141.1 CDS hisI NC_014550.1 2223215 2223616 R catalyses the following reaction: 1-(5- phosphoribosyl)-AMP + H(2)O <=> 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide. Involved in Histidine biosynthesis; phosphoribosyl-AMP cyclohydrolase complement(2223215..2223616) Arthrobacter arilaitensis Re117 9794470 YP_003917142.1 CDS AARI_19520 NC_014550.1 2223733 2224392 D hypothetical protein 2223733..2224392 Arthrobacter arilaitensis Re117 9793968 YP_003917143.1 CDS AARI_19530 NC_014550.1 2224495 2224776 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.654 between position 37 and 38; hypothetical protein 2224495..2224776 Arthrobacter arilaitensis Re117 9794646 YP_003917144.1 CDS AARI_35370 NC_014550.1 2224800 2226077 R transposase of ISAar15, ISL3 family complement(2224800..2226077) Arthrobacter arilaitensis Re117 9794647 YP_003917145.1 CDS AARI_35380 NC_014550.1 2226158 2227237 R transposase of ISAar16, IS110 family complement(2226158..2227237) Arthrobacter arilaitensis Re117 9793478 YP_003917146.1 CDS AARI_19540 NC_014550.1 2227683 2227946 D hypothetical protein 2227683..2227946 Arthrobacter arilaitensis Re117 9793479 YP_003917147.1 CDS AARI_19550 NC_014550.1 2228232 2228867 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.727 between position 27 and 238; hypothetical protein 2228232..2228867 Arthrobacter arilaitensis Re117 9794648 YP_003917148.1 CDS AARI_19560 NC_014550.1 2228867 2229751 D match to protein domain PF00801; PDK domain-containing protein 2228867..2229751 Arthrobacter arilaitensis Re117 9794649 YP_003917149.1 CDS hisF NC_014550.1 2229804 2230574 R imidazole glycerol phosphate synthase converts N1- (5-phosphoribulosyl)-formimino-5-aminoimidazole-4- carboxamide ribonucleotide (PRFAR) to imidazole glycerol phosphate (ImGP) and 5-(5-aminoimidazole-4-carboxamide) ribonucleotide (AICAR). Involved in histidine biosynthesis; imidazole glycerol phosphate synthase, cyclase subunit complement(2229804..2230574) Arthrobacter arilaitensis Re117 9794650 YP_003917150.1 CDS hisG NC_014550.1 2230596 2231444 R catalyses the following reaction: 1-(5-phospho-D- ribosyl)-ATP + diphosphate <=> ATP + 5-phospho-alpha-D- ribose 1-diphosphate. Involved in histidine biosynthesis; ATP phosphoribosyltransferase complement(2230596..2231444) Arthrobacter arilaitensis Re117 9793965 YP_003917151.1 CDS hisE NC_014550.1 2231586 2231849 R catalyses the following reaction: 1-(5- phosphoribosyl)-ATP + H(2)O <=> 1-(5-phosphoribosyl)-AMP + diphosphate. Involved in Histidine biosynthesis; phosphoribosyl-ATP diphosphatase complement(2231586..2231849) Arthrobacter arilaitensis Re117 9793966 YP_003917152.1 CDS ribH NC_014550.1 2231922 2232413 R catalyzes the condensation of 5-amino-6-(1-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4- dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8- lumazine; riboflavin synthase subunit beta complement(2231922..2232413) Arthrobacter arilaitensis Re117 9793964 YP_003917153.1 CDS ribBA NC_014550.1 2232450 2233706 R 3,4-dihydroxy-2-butanone-4-phosphate synthase (4.1. 99.12) catalyses the following reaction: D-ribulose 5- phosphate <=> formate + L-3,4-dihydroxybutan-2-one 4- phosphate. GTP cyclohydrolase II (3.5.4.25) catalyses the following reaction:GTP + 3 H(2)O <=> formate + 2, 5-diamino- 6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate; bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II complement(2232450..2233706) Arthrobacter arilaitensis Re117 9794300 YP_003917154.1 CDS ribE NC_014550.1 2233706 2234329 R catalyzes the biosynthesis of riboflavin (vitamin B2) by dismutation of 6,7-dimethyl-8-(1-D-ribityl)lumazine (Lum): 2 6,7-dimethyl-8-(1-D-ribityl)lumazine => riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6- dihydroxypyrimidine; riboflavin synthase subunit alpha complement(2233706..2234329) Arthrobacter arilaitensis Re117 9794295 YP_003917155.1 CDS ribD NC_014550.1 2234365 2235405 R EC 3.5.4.26 catalyses the following reaction: 2,5- diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3. EC 1. 1.1.193 catalyses the following reaction: 5-amino-6-(5- phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5- phosphoribosylamino)uracil + NADPH; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase complement(2234365..2235405) Arthrobacter arilaitensis Re117 9794297 YP_003917156.1 CDS pnucC NC_014550.1 2235417 2236118 R Nicotinamide Ribonucleoside (NR) Uptake Permease (PnuC) family (TC 4.B.1.y.z). PnuC of Salmonella typhimurium and Haemophilus influenzae are believed to function cooperatively with NadR homologues, multifunctional proteins that together with PnuC, participate in Nicotinamide Ribonucleoside phosphorylation, transport and transcriptional regulation; nicotinamide ribonucleoside transporter PnuC complement(2235417..2236118) Arthrobacter arilaitensis Re117 9794296 YP_003917157.1 CDS rpe NC_014550.1 2236415 2237077 R involved in the pentose phosphate pathway. Catalyzes the interconversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(2236415..2237077) Arthrobacter arilaitensis Re117 9794211 YP_003917158.1 CDS AARI_19660 NC_014550.1 2237106 2238629 R RNA methyltransferase complement(2237106..2238629) Arthrobacter arilaitensis Re117 9794307 YP_003917159.1 CDS fmt NC_014550.1 2238626 2239558 R catalyses the following reaction : 10- formyltetrahydrofolate + L-methionyl-tRNA(fMet) + H(2)O => tetrahydrofolate + N-formylmethionyl-tRNA(fMet). Involved in initiation of protein biosynthesis; methionyl-tRNA formyltransferase complement(2238626..2239558) Arthrobacter arilaitensis Re117 9794651 YP_003917160.1 CDS def NC_014550.1 2239562 2240125 R involved in polypeptide synthesis by removal of the formyl-group from methionine in growing polypeptides; peptide deformylase complement(2239562..2240125) Arthrobacter arilaitensis Re117 9793855 YP_003917161.1 CDS AARI_19690 NC_014550.1 2240219 2241019 R hypothetical protein complement(2240219..2241019) Arthrobacter arilaitensis Re117 9793801 YP_003917162.1 CDS AARI_19700 NC_014550.1 2242243 2242446 D hypothetical protein 2242243..2242446 Arthrobacter arilaitensis Re117 9793634 YP_003917163.1 CDS AARI_19730 NC_014550.1 2243802 2244842 R identified by match to PF03969; AFG1-like ATPase complement(2243802..2244842) Arthrobacter arilaitensis Re117 9794655 YP_003917164.1 CDS AARI_19740 NC_014550.1 2245058 2245972 D thiosulfate sulfurtransferase-like protein 2245058..2245972 Arthrobacter arilaitensis Re117 9794656 YP_003917165.1 CDS AARI_19750 NC_014550.1 2245969 2246409 D identified by match to PF02657. This family consists of the SufE-related proteins. These have been implicated in Fe-S metabolism and export; SufE-like protein 2245969..2246409 Arthrobacter arilaitensis Re117 9794657 YP_003917166.1 CDS AARI_19760 NC_014550.1 2246464 2246967 D match to PF04073: YbaK / prolyl-tRNA synthetases associated domain. This domain of unknown function is found in numerous prokaryote organisms. The structure of YbaK shows a novel fold. This domain also occurs in a number of prolyl-tRNA synthetases (proRS) from prokaryotes. Thus, the domain is thought to be involved in oligo-nucleotide binding, with possible roles in recognition/discrimination or editing of prolyl-tRNA; YbaK domain-containing protein 2246464..2246967 Arthrobacter arilaitensis Re117 9794658 YP_003917167.1 CDS AARI_19770 NC_014550.1 2247092 2247403 D hypothetical protein 2247092..2247403 Arthrobacter arilaitensis Re117 9794659 YP_003917168.1 CDS AARI_19780 NC_014550.1 2247449 2248669 R match to PS00120 pattern: lipases, serine active site; lipase/esterase complement(2247449..2248669) Arthrobacter arilaitensis Re117 9794660 YP_003917169.1 CDS msrB NC_014550.1 2248732 2249175 D plays a role in preventing oxidative-stress damage caused by reactive oxygen species by reducing the oxidized form of methionine back to methionine and thereby reactivating peptides that had been damaged; peptide-methionine (R)-S-oxide reductase 2248732..2249175 Arthrobacter arilaitensis Re117 9794661 YP_003917170.1 CDS AARI_19800 NC_014550.1 2249324 2250709 D hypothetical protein 2249324..2250709 Arthrobacter arilaitensis Re117 9794112 YP_003917171.1 CDS AARI_19810 NC_014550.1 2250753 2251436 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein 2250753..2251436 Arthrobacter arilaitensis Re117 9794662 YP_003917172.1 CDS AARI_19820 NC_014550.1 2251518 2252579 D catalyses the production of glycine and acetaldehyde from threonine; threonine aldolase 2251518..2252579 Arthrobacter arilaitensis Re117 9794663 YP_003917173.1 CDS AARI_19830 NC_014550.1 2252641 2253279 D hypothetical protein 2252641..2253279 Arthrobacter arilaitensis Re117 9794664 YP_003917174.1 CDS AARI_19840 NC_014550.1 2253326 2254576 D ribonuclease D cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3 prime maturation of several stable RNA; ribonuclease D 2253326..2254576 Arthrobacter arilaitensis Re117 9794665 YP_003917175.1 CDS fadA NC_014550.1 2254736 2255986 D also named acetyl-CoA C-acyltransferase. Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. Involved in the aerobic and anaerobic degradation of long-chain fatty acids. Part of the FadAB fatty acid oxidation complex; fatty acid oxidation complex subunit beta 2254736..2255986 Arthrobacter arilaitensis Re117 9794666 YP_003917176.1 CDS fadB NC_014550.1 2255997 2258120 D identified by similarity to protein SP: P21177 (Escherichia coli). Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities. Involved in the aerobic and anaerobic degradation of long-chain fatty acids. Part of the FadAB fatty acid oxidation complex; fatty acid oxidation complex subunit alpha 2255997..2258120 Arthrobacter arilaitensis Re117 9793842 YP_003917177.1 CDS AARI_19870 NC_014550.1 2258365 2258496 R hypothetical protein complement(2258365..2258496) Arthrobacter arilaitensis Re117 9793844 YP_003917178.1 CDS AARI_19880 NC_014550.1 2258496 2260187 R Solute:Sodium Symporter (SSS) family (2.A.21.y.z). Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, organo cations such as choline, nucleosides, inositols, vitamins, urea or anions, depending on the system; Na+/solute symporter complement(2258496..2260187) Arthrobacter arilaitensis Re117 9794667 YP_003917179.1 CDS AARI_19890 NC_014550.1 2261184 2261657 D match to protein domain PF00355; Rieske (2Fe-2S) domain-containing protein 2261184..2261657 Arthrobacter arilaitensis Re117 9794668 YP_003917180.1 CDS AARI_19900 NC_014550.1 2261733 2262743 R identified by match to PF00248 family: Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity; aldo-keto reductase family protein complement(2261733..2262743) Arthrobacter arilaitensis Re117 9794669 YP_003917181.1 CDS argG NC_014550.1 2262843 2264270 D catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate; argininosuccinate synthase 2262843..2264270 Arthrobacter arilaitensis Re117 9794670 YP_003917182.1 CDS AARI_19920 NC_014550.1 2264417 2264752 R hypothetical protein complement(2264417..2264752) Arthrobacter arilaitensis Re117 9793677 YP_003917183.1 CDS AARI_19930 NC_014550.1 2264774 2265235 R hypothetical protein complement(2264774..2265235) Arthrobacter arilaitensis Re117 9794671 YP_003917184.1 CDS AARI_19940 NC_014550.1 2265272 2265841 R hypothetical protein complement(2265272..2265841) Arthrobacter arilaitensis Re117 9794672 YP_003917185.1 CDS AARI_19950 NC_014550.1 2265870 2266490 R hypothetical protein complement(2265870..2266490) Arthrobacter arilaitensis Re117 9794673 YP_003917186.1 CDS dxs NC_014550.1 2266487 2268454 R catalyzes the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1- deoxy-D-xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxal (vitamin B6); 1-deoxy-D-xylulose-5-phosphate synthase complement(2266487..2268454) Arthrobacter arilaitensis Re117 9794674 YP_003917187.1 CDS AARI_19970 NC_014550.1 2268572 2269477 R match to PF01636. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides. The aminoglycoside phosphotransferases inactivate aminoglycoside antibiotics via phosphorylation. This family also includes homoserine kinase; phosphotransferase complement(2268572..2269477) Arthrobacter arilaitensis Re117 9793832 YP_003917188.1 CDS AARI_19980 NC_014550.1 2269581 2270195 D identified by match to protein domain PF08241; SAM-dependent methyltransferase 2269581..2270195 Arthrobacter arilaitensis Re117 9794675 YP_003917189.1 CDS acn NC_014550.1 2270294 2273002 R catalyzes the reversible isomerization of citrate and isocitrate. Cis-aconitate is formed as an intermediary product during the course of the reaction; aconitate hydratase complement(2270294..2273002) Arthrobacter arilaitensis Re117 9794676 YP_003917190.1 CDS AARI_20000 NC_014550.1 2273194 2274516 R RNA methyltransferase complement(2273194..2274516) Arthrobacter arilaitensis Re117 9793650 YP_003917191.1 CDS AARI_20010 NC_014550.1 2274541 2276541 R 11 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2274541..2276541) Arthrobacter arilaitensis Re117 9794677 YP_003917192.1 CDS trkA NC_014550.1 2276687 2277364 D voltage-gated K+ Channel beta-subunit family, TrkA regulatory subunit of TrkH and TrkG (TC 8.A.5.2.1). Part of a potassium transport system (regulatory subunit). TrkA domains can bind NAD+ and NADH, possibly allowing K+ transporters to be responsive to the redox state of the cell. Systems regulated by TrkA include TrkG/H (TC 2.A.38. 1.1); Trk system potassium uptake protein TrkA 2276687..2277364 Arthrobacter arilaitensis Re117 9794678 YP_003917193.1 CDS trkA NC_014550.1 2277380 2278045 D voltage-gated K+ Channel beta-subunit family, TrkA regulatory subunit of TrkH and TrkG (TC 8.A.5.2.1). Part of a potassium transport system (regulatory subunit). TrkA domains can bind NAD+ and NADH, possibly allowing K+ transporters to be responsive to the redox state of the cell. Systems regulated by TrkA include TrkG/H (TC 2.A.38. 1.1); Trk system potassium uptake protein TrkA 2277380..2278045 Arthrobacter arilaitensis Re117 9794460 YP_003917194.1 CDS AARI_20040 NC_014550.1 2278042 2278770 R 6 transmembranes helices predicted by TMHMM2.0; hypothetical protein complement(2278042..2278770) Arthrobacter arilaitensis Re117 9794461 YP_003917195.1 CDS AARI_20050 NC_014550.1 2278833 2279207 R hypothetical protein complement(2278833..2279207) Arthrobacter arilaitensis Re117 9794679 YP_003917196.1 CDS AARI_20060 NC_014550.1 2279211 2279900 R hypothetical protein complement(2279211..2279900) Arthrobacter arilaitensis Re117 9794680 YP_003917197.1 CDS dut NC_014550.1 2279939 2280397 R removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA; dUTP diphosphatase complement(2279939..2280397) Arthrobacter arilaitensis Re117 9794681 YP_003917198.1 CDS AARI_20080 NC_014550.1 2280539 2281072 D 2 transmembranes helices predicted by TMHMM2.0; hypothetical protein 2280539..2281072 Arthrobacter arilaitensis Re117 9793830 YP_003917199.1 CDS AARI_20090 NC_014550.1 2281164 2281463 R hypothetical protein complement(2281164..2281463) Arthrobacter arilaitensis Re117 9794682 YP_003917200.1 CDS AARI_20100 NC_014550.1 2281726 2282793 D hypothetical protein 2281726..2282793 Arthrobacter arilaitensis Re117 9794683 YP_003917201.1 CDS AARI_20110 NC_014550.1 2282883 2284067 R match to protein family PF01663. This family consists of phosphodiesterases. They catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars; type I phosphodiesterase / nucleotide pyrophosphatase complement(2282883..2284067) Arthrobacter arilaitensis Re117 9794684 YP_003917202.1 CDS AARI_20120 NC_014550.1 2284070 2284657 R hypothetical protein complement(2284070..2284657) Arthrobacter arilaitensis Re117 9794685 YP_003917203.1 CDS AARI_20130 NC_014550.1 2284709 2287369 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2284709..2287369) Arthrobacter arilaitensis Re117 9794686 YP_003917204.1 CDS AARI_20140 NC_014550.1 2287468 2290101 D DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings. Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis; DNA gyrase subunit A 2287468..2290101 Arthrobacter arilaitensis Re117 9794687 YP_003917205.1 CDS cydDC NC_014550.1 2290171 2293494 R TCDB: ATP-binding cassette (ABC) superfamily, CydDC cysteine exporter (CydDC-E) family (TC 3.A.1.129.z). ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC)2, DPL-family, CYD-subfamily (Cytochrome bd biogenesis and cysteine export); cytochrome bd biosynthesis ABC transporter ATPase/permease complement(2290171..2293494) Arthrobacter arilaitensis Re117 9794688 YP_003917206.1 CDS cydB NC_014550.1 2293521 2294546 R the cytochrome bd oxidase is a widely distributed prokaryotic quinol oxidase, which performs a variety of physiological functions in vivo. It is involved in energy- transducing respiration in Escherichia coli and Bacillus species. It plays also a role in aerotolerant nitrogen fixation and protection against metal toxicity and oxidative stress in Azotobacter vinelandii; cytochrome bd oxidase subunit 2 complement(2293521..2294546) Arthrobacter arilaitensis Re117 9793773 YP_003917207.1 CDS cydA NC_014550.1 2294572 2296164 R the cytochrome bd oxidase is a widely distributed prokaryotic quinol oxidase, which performs a variety of physiological functions in vivo. It is involved in energy- transducing respiration in Escherichia coli and Bacillus species. It plays also a role in aerotolerant nitrogen fixation and protection against metal toxicity and oxidative stress in Azotobacter vinelandii; cytochrome bd oxidase subunit 1 complement(2294572..2296164) Arthrobacter arilaitensis Re117 9793772 YP_003917208.1 CDS AARI_20180 NC_014550.1 2296561 2296932 D identified by match to protein family PF03965: penicillinase repressor; transcriptional repressor 2296561..2296932 Arthrobacter arilaitensis Re117 9793771 YP_003917209.1 CDS AARI_20190 NC_014550.1 2296956 2297918 D match to protein family PF05569. production of beta- Lactamase and penicillin-binding protein 2a (which mediate staphylococcal resistance to beta-lactam antibiotics) is regulated by a signal-transducing integral membrane protein and a transcriptional repressor. The signal transducer is a fusion protein with penicillin-binding and zinc metalloprotease domains. The signal for protein expression is transmitted by site-specific proteolytic cleavage of both the transducer, which auto-activates, and the repressor, which is inactivated, unblocking gene transcription; M56 family peptidase 2296956..2297918 Arthrobacter arilaitensis Re117 9794689 YP_003917210.1 CDS gyrB NC_014550.1 2297989 2300097 R DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings. Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis; DNA gyrase subunit B complement(2297989..2300097) Arthrobacter arilaitensis Re117 9794690 YP_003917211.1 CDS AARI_20210 NC_014550.1 2300319 2300543 D hypothetical protein 2300319..2300543 Arthrobacter arilaitensis Re117 9793945 YP_003917212.1 CDS rpoD NC_014550.1 2300673 2301884 R RpoD is a primary sigma factor and directs the transcription of a wide variety of genes. Match to protein family TIGR02393; RNA polymerase sigma factor RpoD complement(2300673..2301884) Arthrobacter arilaitensis Re117 9794691 YP_003917213.1 CDS AARI_20230 NC_014550.1 2302140 2303243 R hypothetical protein complement(2302140..2303243) Arthrobacter arilaitensis Re117 9794345 YP_003917214.1 CDS AARI_20240 NC_014550.1 2303330 2304592 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(2303330..2304592) Arthrobacter arilaitensis Re117 9794692 YP_003917215.1 CDS AARI_20250 NC_014550.1 2304589 2305551 R hypothetical protein complement(2304589..2305551) Arthrobacter arilaitensis Re117 9794693 YP_003917216.1 CDS pepA NC_014550.1 2305808 2307322 D selectively releases N-terminal amino acid residues from polypeptides and proteins. It is in general involved in the processing, catabolism and degradation of intracellular proteins; leucyl aminopeptidase 2305808..2307322 Arthrobacter arilaitensis Re117 9794694 YP_003917217.1 CDS lpdA NC_014550.1 2307607 2308986 D E3 component of pyruvate dehydrogenase and 2- oxoglutarate dehydrogenase complexes; dihydrolipoyl dehydrogenase 2307607..2308986 Arthrobacter arilaitensis Re117 9794192 YP_003917218.1 CDS sucB NC_014550.1 2309105 2310745 D it is a component of the multienzyme 2-oxoglutarate dehydrogenase complex, which is involved in the TCA cycle; dihydrolipoyllysine-residue succinyltransferase 2309105..2310745 Arthrobacter arilaitensis Re117 9794044 YP_003917219.1 CDS AARI_20290 NC_014550.1 2310857 2311207 D 4 transmembranes helices predicted by TMHMM2.0; hypothetical protein 2310857..2311207 Arthrobacter arilaitensis Re117 9794410 YP_003917220.1 CDS AARI_35390 NC_014550.1 2312723 2314030 D transposase of ISAar19, ISL3 family 2312723..2314030 Arthrobacter arilaitensis Re117 9794696 YP_003917221.1 CDS lipB NC_014550.1 2314359 2315006 D first committed step in the biosynthesis of lipoyl cofactor. The lipoyl cofactor is essential for the function of several key enzymes involved in oxidative metabolism; lipoyl(octanoyl) transferase 2314359..2315006 Arthrobacter arilaitensis Re117 9793480 YP_003917222.1 CDS lipA NC_014550.1 2315040 2316038 D catalyzes the final step in the de-novo biosynthesis of the lipoyl cofactor, with the other enzyme involved being EC 2.3.1.181; lipoyl synthase 2315040..2316038 Arthrobacter arilaitensis Re117 9794040 YP_003917223.1 CDS AARI_20330 NC_014550.1 2316209 2316958 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2316209..2316958 Arthrobacter arilaitensis Re117 9794039 YP_003917224.1 CDS AARI_20340 NC_014550.1 2317028 2317465 R match to PF06271; RDD domain-containing protein complement(2317028..2317465) Arthrobacter arilaitensis Re117 9794697 YP_003917225.1 CDS glnA NC_014550.1 2317740 2319164 D plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. The activity of class I glutamate--ammonia ligase is controlled by the adenylation of a tyrosine residue. The adenylated enzyme is inactive; glutamate--ammonia ligase, type I 2317740..2319164 Arthrobacter arilaitensis Re117 9794698 YP_003917226.1 CDS AARI_20360 NC_014550.1 2319179 2320294 R match to protein family PF00589; phage integrase complement(2319179..2320294) Arthrobacter arilaitensis Re117 9793906 YP_003917227.1 CDS AARI_20370 NC_014550.1 2320291 2320737 R match to PF01381. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein complement(2320291..2320737) Arthrobacter arilaitensis Re117 9794699 YP_003917228.1 CDS AARI_20390 NC_014550.1 2321033 2321650 D hypothetical protein 2321033..2321650 Arthrobacter arilaitensis Re117 9794701 YP_003917229.1 CDS AARI_20400 NC_014550.1 2321643 2321759 D hypothetical protein 2321643..2321759 Arthrobacter arilaitensis Re117 9794702 YP_003917230.1 CDS AARI_20410 NC_014550.1 2321788 2321976 D hypothetical protein 2321788..2321976 Arthrobacter arilaitensis Re117 9794703 YP_003917231.1 CDS AARI_20420 NC_014550.1 2322021 2322920 D hypothetical protein 2322021..2322920 Arthrobacter arilaitensis Re117 9794704 YP_003917232.1 CDS AARI_20430 NC_014550.1 2322917 2323057 D hypothetical protein 2322917..2323057 Arthrobacter arilaitensis Re117 9794705 YP_003917233.1 CDS AARI_20440 NC_014550.1 2323063 2323242 D hypothetical protein 2323063..2323242 Arthrobacter arilaitensis Re117 9794706 YP_003917234.1 CDS AARI_20450 NC_014550.1 2323242 2323559 D hypothetical protein 2323242..2323559 Arthrobacter arilaitensis Re117 9794707 YP_003917235.1 CDS AARI_20460 NC_014550.1 2323564 2323749 D hypothetical protein 2323564..2323749 Arthrobacter arilaitensis Re117 9794708 YP_003917236.1 CDS AARI_20470 NC_014550.1 2323761 2324711 D hypothetical protein 2323761..2324711 Arthrobacter arilaitensis Re117 9794709 YP_003917237.1 CDS AARI_35400 NC_014550.1 2324766 2325092 D transposase of ISAar26, IS3 family, IS3 group, orfA 2324766..2325092 Arthrobacter arilaitensis Re117 9794710 YP_003917238.1 CDS AARI_35410 NC_014550.1 2325092 2326000 D Transposase of ISAar26, IS3 family, IS3 group, orfB 2325092..2326000 Arthrobacter arilaitensis Re117 9793481 YP_003917239.1 CDS AARI_20480 NC_014550.1 2326418 2326834 D hypothetical protein 2326418..2326834 Arthrobacter arilaitensis Re117 9793482 YP_003917240.1 CDS AARI_20490 NC_014550.1 2326896 2327495 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.536 between position 40 and 41; hypothetical protein complement(2326896..2327495) Arthrobacter arilaitensis Re117 9794711 YP_003917241.1 CDS AARI_20500 NC_014550.1 2327553 2327771 R similar to protein Gp28 (SP:Q855T5; Mycobacterium phage Che9d); hypothetical protein complement(2327553..2327771) Arthrobacter arilaitensis Re117 9794712 YP_003917242.1 CDS AARI_20510 NC_014550.1 2327768 2327914 R hypothetical protein complement(2327768..2327914) Arthrobacter arilaitensis Re117 9794713 YP_003917243.1 CDS AARI_20520 NC_014550.1 2328216 2328701 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.991) with cleavage site probability 0.664 between position 32 and 33; hypothetical protein complement(2328216..2328701) Arthrobacter arilaitensis Re117 9794714 YP_003917244.1 CDS AARI_20530 NC_014550.1 2328789 2329007 R similar to protein Gp28 (SP:Q855T5; Mycobacterium phage Che9d); hypothetical protein complement(2328789..2329007) Arthrobacter arilaitensis Re117 9794715 YP_003917245.1 CDS AARI_20540 NC_014550.1 2329518 2329676 D hypothetical protein 2329518..2329676 Arthrobacter arilaitensis Re117 9794716 YP_003917246.1 CDS AARI_20550 NC_014550.1 2329985 2330455 R nucleoside deaminase-like protein complement(2329985..2330455) Arthrobacter arilaitensis Re117 9794717 YP_003917247.1 CDS AARI_20560 NC_014550.1 2330562 2331044 R hypothetical protein complement(2330562..2331044) Arthrobacter arilaitensis Re117 9794718 YP_003917248.1 CDS glnE NC_014550.1 2331053 2334079 R regulates the activity of glutamate--ammonia ligase by attachment of the adenylyl moiety of ATP; [Glutamate--ammonia ligase] adenylyltransferase complement(2331053..2334079) Arthrobacter arilaitensis Re117 9794719 YP_003917249.1 CDS glnA NC_014550.1 2334132 2335472 R plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. The activity of class I glutamate--ammonia ligase is controlled by the adenylation of a tyrosine residue. The adenylated enzyme is inactive; glutamate--ammonia ligase, type I complement(2334132..2335472) Arthrobacter arilaitensis Re117 9793908 YP_003917250.1 CDS panB NC_014550.1 2335609 2336445 D catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate: 5,10-methylenetetrahydrofolate + 3-methyl-2- oxobutanoate + H2O = tetrahydrofolate + 2-dehydropantoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 2335609..2336445 Arthrobacter arilaitensis Re117 9793907 YP_003917251.1 CDS AARI_20600 NC_014550.1 2336555 2336749 R hypothetical protein complement(2336555..2336749) Arthrobacter arilaitensis Re117 9794173 YP_003917252.1 CDS map NC_014550.1 2336884 2337759 D responsible for the removal of the amino-terminal (initiator) methionine from nascent eukaryotic cytosolic and cytoplasmic prokaryotic proteins if the penultimate amino acid is small and uncharged; methionyl aminopeptidase 2336884..2337759 Arthrobacter arilaitensis Re117 9794720 YP_003917253.1 CDS AARI_20620 NC_014550.1 2337837 2338325 R transcriptional regulator complement(2337837..2338325) Arthrobacter arilaitensis Re117 9794059 YP_003917254.1 CDS hisD NC_014550.1 2338410 2339762 R catalyzes the terminal step in the biosynthesis of histidine, the four-electron oxidation of L-histidinol to histidine; histidinol dehydrogenase complement(2338410..2339762) Arthrobacter arilaitensis Re117 9794721 YP_003917255.1 CDS dnaE NC_014550.1 2339840 2343349 R DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta prime, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit alpha complement(2339840..2343349) Arthrobacter arilaitensis Re117 9793963 YP_003917256.1 CDS AARI_20650 NC_014550.1 2343509 2344453 R identified by match to protein family PF00849. Pseudouridylate synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5- ribosyluracil, psi); pseudouridylate synthase complement(2343509..2344453) Arthrobacter arilaitensis Re117 9793823 YP_003917257.1 CDS lspA NC_014550.1 2344450 2345031 R releases signal peptides from bacterial membrane prolipoproteins; signal peptidase II complement(2344450..2345031) Arthrobacter arilaitensis Re117 9794722 YP_003917258.1 CDS AARI_20670 NC_014550.1 2345129 2345878 R match to PF05103; DivIVA family protein complement(2345129..2345878) Arthrobacter arilaitensis Re117 9794047 YP_003917259.1 CDS AARI_20680 NC_014550.1 2346108 2346404 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2346108..2346404) Arthrobacter arilaitensis Re117 9794723 YP_003917260.1 CDS AARI_20690 NC_014550.1 2346428 2346979 R hypothetical protein complement(2346428..2346979) Arthrobacter arilaitensis Re117 9794724 YP_003917261.1 CDS AARI_20700 NC_014550.1 2347077 2347826 R hypothetical protein complement(2347077..2347826) Arthrobacter arilaitensis Re117 9794725 YP_003917262.1 CDS ftsZ NC_014550.1 2347847 2349037 R FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. It is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. It forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells; cell division protein FtsZ complement(2347847..2349037) Arthrobacter arilaitensis Re117 9794726 YP_003917263.1 CDS AARI_20720 NC_014550.1 2349256 2349990 R match to PF08478: POTRA domain, FtsQ-type. The POTRA domain (for polypeptide-transport-associated domain) is found in different types of proteins, usually associated with a transmembrane beta-barrel; POTRA domain-containing protein complement(2349256..2349990) Arthrobacter arilaitensis Re117 9793871 YP_003917264.1 CDS murC NC_014550.1 2350053 2351450 R involved in peptidoglycan biosynthesis; UDP-N-acetylmuramate--L-alanine ligase complement(2350053..2351450) Arthrobacter arilaitensis Re117 9794727 YP_003917265.1 CDS murG NC_014550.1 2351455 2352576 R catalyzes the following reaction: UDP-N- acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D- Ala-D-Ala)- diphosphoundecaprenol <=> UDP + GlcNAc-(1->4)- Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D- Ala)- diphosphoundecaprenol. Involved in peptidoglycan biosynthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase complement(2351455..2352576) Arthrobacter arilaitensis Re117 9794118 YP_003917266.1 CDS ftsW NC_014550.1 2352677 2353930 R plays a role in the stabilization of the FtsZ ring during cell division; cell division protein FtsW complement(2352677..2353930) Arthrobacter arilaitensis Re117 9794122 YP_003917267.1 CDS murD NC_014550.1 2353974 2355503 R involved in peptidoglycan biosynthesis; UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase complement(2353974..2355503) Arthrobacter arilaitensis Re117 9793868 YP_003917268.1 CDS mraY NC_014550.1 2355500 2356603 R catalyzes the formation of undecaprenyl- pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP- MurNAc-pentapeptide and undecaprenyl-phosphate. Involved in peptidoglycan biosynthesis; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(2355500..2356603) Arthrobacter arilaitensis Re117 9794119 YP_003917269.1 CDS murF NC_014550.1 2356600 2358057 R involved in peptidoglycan biosynthesis: ATP + UDP-N- acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D- alanyl-D-alanine => ADP + phosphate + UDP-N-acetylmuramoyl- L-alanyl-gamma-D-glutamyl-L-lysyl-D- alanyl-D-alanine. Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2, 4-diaminoheptanedioate (acylated at its L-center); UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase complement(2356600..2358057) Arthrobacter arilaitensis Re117 9794106 YP_003917270.1 CDS murE NC_014550.1 2358108 2359700 R catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D- glutamate (UMAG) in the biosynthesis of bacterial cell- wall peptidoglycan. Corresponds probably to EC 6.3.2.7 rather than 6.3.2.13, as the cell-wall peptidoglycan type of Arthrobacter arilaitensis is Lys-Glu (variation A4alpha); UDP-N-acetylmuramyl-tripeptide synthetase complement(2358108..2359700) Arthrobacter arilaitensis Re117 9794121 YP_003917271.1 CDS AARI_20800 NC_014550.1 2359694 2361472 R match to PF00905. The large number of penicillin binding proteins, which are represented in this group of sequences, are responsible for the final stages of peptidoglycan biosynthesis for cell wall formation. The proteins synthesise cross-linked peptidoglycan from lipid intermediates, and contain a penicillin-sensitive transpeptidase carboxy-terminal domain; penicillin-binding protein complement(2359694..2361472) Arthrobacter arilaitensis Re117 9794120 YP_003917272.1 CDS AARI_20810 NC_014550.1 2361583 2362353 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(2361583..2362353) Arthrobacter arilaitensis Re117 9794728 YP_003917273.1 CDS mraW NC_014550.1 2362355 2363347 R S-adenosyl-L-methionine-dependent methyltransferase MraW complement(2362355..2363347) Arthrobacter arilaitensis Re117 9794729 YP_003917274.1 CDS mraZ NC_014550.1 2363519 2363932 R this protein often is found with other genes of the dcw (division cell wall) gene cluster, including mraW, ftsI, murE, murF, ftsW, murG, etc.; MraZ protein complement(2363519..2363932) Arthrobacter arilaitensis Re117 9794105 YP_003917275.1 CDS AARI_20840 NC_014550.1 2364450 2364833 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2364450..2364833) Arthrobacter arilaitensis Re117 9794107 YP_003917276.1 CDS dinB NC_014550.1 2365016 2366182 R DNA polymerase IV is involved in DNA repair; DNA polymerase IV complement(2365016..2366182) Arthrobacter arilaitensis Re117 9794730 YP_003917277.1 CDS crtE NC_014550.1 2366345 2367451 D identified by similarity to protein SP:Q9KK76 (Brevibacterium linens). A variety of isoprenoid compounds are synthesized by various organisms. In bacteria this pathway leads to the synthesis of isopentenyl tRNA, isoprenoid quinones, and sugar carrier lipids. Farnesyltranstransferase catalyzes the sequential addition of the three molecules of isopentenyl pyrophosphate onto dimethylallyl pyrophosphate to form geranylgeranyl pyrophosphate; farnesyltranstransferase 2366345..2367451 Arthrobacter arilaitensis Re117 9793814 YP_003917278.1 CDS AARI_20870 NC_014550.1 2367552 2367905 R hypothetical protein complement(2367552..2367905) Arthrobacter arilaitensis Re117 9793759 YP_003917279.1 CDS AARI_20880 NC_014550.1 2368112 2369812 D match to protein domain PF01476. This domain is about 40 residues long and is found in a variety of enzymes involved in bacterial cell wall degradation. It may have a general peptidoglycan binding function; LysM domain-containing protein 2368112..2369812 Arthrobacter arilaitensis Re117 9794731 YP_003917280.1 CDS AARI_20890 NC_014550.1 2369888 2371375 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(2369888..2371375) Arthrobacter arilaitensis Re117 9794732 YP_003917281.1 CDS gdh NC_014550.1 2371385 2376178 R catalyzes the NAD-dependent reversible oxidative deamination of glutamate to 2-oxoglutarate and ammonia; NAD-specific glutamate dehydrogenase complement(2371385..2376178) Arthrobacter arilaitensis Re117 9794733 YP_003917282.1 CDS AARI_20910 NC_014550.1 2376304 2377551 R hypothetical protein complement(2376304..2377551) Arthrobacter arilaitensis Re117 9793895 YP_003917283.1 CDS AARI_20920 NC_014550.1 2377548 2378213 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(2377548..2378213) Arthrobacter arilaitensis Re117 9794734 YP_003917284.1 CDS AARI_20930 NC_014550.1 2378304 2378864 R hypothetical protein complement(2378304..2378864) Arthrobacter arilaitensis Re117 9794735 YP_003917285.1 CDS AARI_20940 NC_014550.1 2378987 2379709 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2378987..2379709 Arthrobacter arilaitensis Re117 9794736 YP_003917286.1 CDS AARI_20950 NC_014550.1 2379753 2380274 D hypothetical protein 2379753..2380274 Arthrobacter arilaitensis Re117 9794737 YP_003917287.1 CDS secA NC_014550.1 2380271 2382916 R the translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF); preprotein translocase subunit SecA complement(2380271..2382916) Arthrobacter arilaitensis Re117 9794738 YP_003917288.1 CDS AARI_20970 NC_014550.1 2383050 2384222 R hypothetical protein complement(2383050..2384222) Arthrobacter arilaitensis Re117 9794386 YP_003917289.1 CDS AARI_20980 NC_014550.1 2384246 2384944 R match to protein family PF02482; ribosome-associated protein complement(2384246..2384944) Arthrobacter arilaitensis Re117 9794739 YP_003917290.1 CDS AARI_20990 NC_014550.1 2385114 2385902 R match to protein domain PF00156. This family includes a range of diverse phosphoribosyl transferase enzymes; phosphoribosyl transferase complement(2385114..2385902) Arthrobacter arilaitensis Re117 9794740 YP_003917291.1 CDS lpqB NC_014550.1 2385972 2387675 R possible role in the MtrAB signal transduction pathway; lipoprotein LpqB complement(2385972..2387675) Arthrobacter arilaitensis Re117 9794741 YP_003917292.1 CDS mtrB NC_014550.1 2387675 2389495 R member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals; sensor histidine kinase MtrB complement(2387675..2389495) Arthrobacter arilaitensis Re117 9794046 YP_003917293.1 CDS mtrA NC_014550.1 2389492 2390172 R member of the two-component regulatory system mtrA/mtrB; DNA-binding response regulator MtrA complement(2389492..2390172) Arthrobacter arilaitensis Re117 9794115 YP_003917294.1 CDS AARI_21030 NC_014550.1 2390308 2391372 R hypothetical protein complement(2390308..2391372) Arthrobacter arilaitensis Re117 9794114 YP_003917295.1 CDS aroH NC_014550.1 2391365 2391736 R catalyzes the Claisen rearrangement of chorismate to prephenate, which can subsequently be converted to precursors of either phenylalanine or tyrosine; chorismate mutase complement(2391365..2391736) Arthrobacter arilaitensis Re117 9794742 YP_003917296.1 CDS AARI_21050 NC_014550.1 2391848 2393539 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, fused ATP-binding protein (ABC2), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit complement(2391848..2393539) Arthrobacter arilaitensis Re117 9793687 YP_003917297.1 CDS AARI_21060 NC_014550.1 2393536 2394522 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit complement(2393536..2394522) Arthrobacter arilaitensis Re117 9794743 YP_003917298.1 CDS AARI_21070 NC_014550.1 2394525 2395616 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit complement(2394525..2395616) Arthrobacter arilaitensis Re117 9794744 YP_003917299.1 CDS AARI_21080 NC_014550.1 2395763 2397397 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein complement(2395763..2397397) Arthrobacter arilaitensis Re117 9794745 YP_003917300.1 CDS AARI_21090 NC_014550.1 2397626 2397985 D hypothetical protein 2397626..2397985 Arthrobacter arilaitensis Re117 9794746 YP_003917301.1 CDS AARI_21100 NC_014550.1 2398074 2400779 R 13 transmembrane helices predicted by TMHMM2.0. Match to protein domain PF07732: multicopper oxidase; hypothetical protein complement(2398074..2400779) Arthrobacter arilaitensis Re117 9794747 YP_003917302.1 CDS AARI_21110 NC_014550.1 2400772 2401902 R 10 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2400772..2401902) Arthrobacter arilaitensis Re117 9794748 YP_003917303.1 CDS AARI_21120 NC_014550.1 2401899 2402579 R transcriptional regulator complement(2401899..2402579) Arthrobacter arilaitensis Re117 9794749 YP_003917304.1 CDS AARI_21130 NC_014550.1 2402716 2403033 D hypothetical protein 2402716..2403033 Arthrobacter arilaitensis Re117 9794750 YP_003917305.1 CDS mnmA NC_014550.1 2403092 2404228 R catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34; tRNA-specific 2-thiouridylase MnmA complement(2403092..2404228) Arthrobacter arilaitensis Re117 9794751 YP_003917306.1 CDS AARI_21150 NC_014550.1 2404225 2405460 R identified by match to protein family PIRSF005572: cysteine desulfurase, NifS type. Cysteine desulfurase catalyses the following reaction: L-cysteine + [enzyme]- cysteine <=> L-alanine + [enzyme]-S-sulfanylcysteine. It is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) and functions by mobilizing sulfur; cysteine desulfurase complement(2404225..2405460) Arthrobacter arilaitensis Re117 9794090 YP_003917307.1 CDS AARI_21160 NC_014550.1 2405490 2406299 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.912) with cleavage site probability 0.909 between position 28 and 29; hypothetical protein complement(2405490..2406299) Arthrobacter arilaitensis Re117 9794752 YP_003917308.1 CDS AARI_21170 NC_014550.1 2406412 2407338 D catalyzes the condensation of 6-hydroxymethyl-7,8- dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7,8-dihydropteroate. This is the second step in the three steps pathway leading from 6-hydroxymethyl-7,8- dihydropterin to 7,8-dihydrofolate. It is the target of sulfonamides which are substrates analog that compete with para-aminobenzoic acid; dihydropteroate synthase 2406412..2407338 Arthrobacter arilaitensis Re117 9794753 YP_003917309.1 CDS AARI_21180 NC_014550.1 2407352 2408110 D match to protein domain PF01872. This domain is found in the C-terminus of the bifunctional deaminase- reductase in combination with PF00383 as well as in isolation in some archaebacterial proteins; RibD domain-containing protein 2407352..2408110 Arthrobacter arilaitensis Re117 9794754 YP_003917310.1 CDS AARI_21190 NC_014550.1 2408079 2408978 R match to protein domain PF00781; diacylglycerol kinase catalytic domain-containing protein complement(2408079..2408978) Arthrobacter arilaitensis Re117 9794755 YP_003917311.1 CDS AARI_21200 NC_014550.1 2409095 2409994 D match to protein domain PF0026; DnaJ domain-containing protein 2409095..2409994 Arthrobacter arilaitensis Re117 9794756 YP_003917312.1 CDS AARI_21210 NC_014550.1 2410039 2410500 D identified by match to protein family PF00588: SpoU rRNA Methylase family. Possible role in rRNA modification; RNA methyltransferase 2410039..2410500 Arthrobacter arilaitensis Re117 9794757 YP_003917313.1 CDS AARI_21220 NC_014550.1 2410624 2411181 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 2410624..2411181 Arthrobacter arilaitensis Re117 9794758 YP_003917314.1 CDS AARI_21230 NC_014550.1 2411274 2412035 R LmbE family protein complement(2411274..2412035) Arthrobacter arilaitensis Re117 9794759 YP_003917315.1 CDS fixB NC_014550.1 2412032 2412976 R identified by match to PIRSF000089. Electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, (housekeeping) ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II). They consist of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit; electron transfer flavoprotein subunit alpha complement(2412032..2412976) Arthrobacter arilaitensis Re117 9794760 YP_003917316.1 CDS fixA NC_014550.1 2412989 2413810 R electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, (housekeeping) ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II). They consist of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit; electron transfer flavoprotein subunit beta complement(2412989..2413810) Arthrobacter arilaitensis Re117 9793853 YP_003917317.1 CDS AARI_21260 NC_014550.1 2414001 2415491 R 1 transmembrane helice predicted by TMHMM2.0; serine protease complement(2414001..2415491) Arthrobacter arilaitensis Re117 9793851 YP_003917318.1 CDS AARI_21270 NC_014550.1 2415733 2417805 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.994 between position 28 and 29. Presence of transmembrane helices; hypothetical protein 2415733..2417805 Arthrobacter arilaitensis Re117 9794761 YP_003917319.1 CDS AARI_21280 NC_014550.1 2417876 2418607 D identified by match to protein family PF04012. This family includes PspA, which is a protein that suppresses sigma54-dependent transcription; pspA/IM30 family protein 2417876..2418607 Arthrobacter arilaitensis Re117 9794762 YP_003917320.1 CDS AARI_21290 NC_014550.1 2419738 2422773 R identified by match to PF03699: Uncharacterised protein family (UPF0182). This family contains uncharacterised integral membrane proteins; hypothetical protein complement(2419738..2422773) Arthrobacter arilaitensis Re117 9793637 YP_003917321.1 CDS AARI_21300 NC_014550.1 2422904 2424019 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(2422904..2424019) Arthrobacter arilaitensis Re117 9794764 YP_003917322.1 CDS AARI_21310 NC_014550.1 2424203 2425642 D hypothetical protein 2424203..2425642 Arthrobacter arilaitensis Re117 9794765 YP_003917323.1 CDS AARI_21320 NC_014550.1 2425706 2426383 R hypothetical protein complement(2425706..2426383) Arthrobacter arilaitensis Re117 9794766 YP_003917324.1 CDS AARI_21330 NC_014550.1 2426447 2428570 R match to protein family PS51198: UvrD-like DNA helicase ATP-binding domain profile and PS51217: DNA helicase, UvrD-like, C terminal. UvrD-like DNA helicases belong to superfamily 1 (SF1); ATP-dependent DNA helicase complement(2426447..2428570) Arthrobacter arilaitensis Re117 9794767 YP_003917325.1 CDS nudC NC_014550.1 2428567 2429496 R NAD(+) diphosphatase catalyses the following reaction: NAD(+) + H(2)O <=> AMP + NMN; NAD(+) diphosphatase complement(2428567..2429496) Arthrobacter arilaitensis Re117 9794768 YP_003917326.1 CDS AARI_21350 NC_014550.1 2429664 2430938 D identified by match to PF01636. This family consists of bacterial antibiotic resistance proteins, which confer resistance to various aminoglycosides. It also includes homoserine kinase; aminoglycoside phosphotransferase-like protein 2429664..2430938 Arthrobacter arilaitensis Re117 9794152 YP_003917327.1 CDS AARI_21360 NC_014550.1 2430962 2434279 R match to protein family PS51198: UvrD-like DNA helicase ATP-binding domain profile and PS51217: DNA helicase, UvrD-like, C terminal. UvrD-like DNA helicases belong to superfamily 1 (SF1); ATP-dependent DNA helicase complement(2430962..2434279) Arthrobacter arilaitensis Re117 9794769 YP_003917328.1 CDS AARI_21370 NC_014550.1 2434276 2437488 R match to protein family PS51198: UvrD-like DNA helicase ATP-binding domain profile and PS51217: DNA helicase, UvrD-like, C terminal. UvrD-like DNA helicases belong to superfamily 1 (SF1); ATP-dependent DNA helicase complement(2434276..2437488) Arthrobacter arilaitensis Re117 9794770 YP_003917329.1 CDS AARI_21380 NC_014550.1 2437485 2437874 R involved in the repair of alkylated DNA; methylated-DNA--[protein]-cysteine S-methyltransferase complement(2437485..2437874) Arthrobacter arilaitensis Re117 9794771 YP_003917330.1 CDS AARI_21390 NC_014550.1 2437963 2438646 D DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The beta chain is required for initiation of replication once it is clamped onto DNA. DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII complex. PolIII associates with the gamma complex (composed of gamma, delta, delta, psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex; DNA polymerase III subunit epsilon 2437963..2438646 Arthrobacter arilaitensis Re117 9794772 YP_003917331.1 CDS metN NC_014550.1 2438893 2439885 D TCDB: ATP-binding cassette (ABC) superfamily, methionine uptake transporter (MUT) family (TC3.A.1.24). ABCISSE: ABC transporter, ATP-binding protein (ABC), DLM- family. Part of the ABC transporter complex MetNIQ involved in methionine import. The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ); methionine ABC transporter ATP-binding subunit MetN 2438893..2439885 Arthrobacter arilaitensis Re117 9794773 YP_003917332.1 CDS metI NC_014550.1 2439889 2440554 D TCDB: ATP-binding cassette (ABC) superfamily, methionine uptake transporter (MUT) family (TC3.A.1.24). ABCISSE: ABC transporter, permease (IM), DLM-family. Part of the ABC transporter complex MetNIQ involved in methionine import. The complex is composed of two ATP- binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ); methionine ABC transporter inner membrane subunit MetI 2439889..2440554 Arthrobacter arilaitensis Re117 9794076 YP_003917333.1 CDS metQ NC_014550.1 2440660 2441508 D TCDB: ATP-binding cassette (ABC) superfamily, methionine uptake transporter (MUT) family (TC3.A.1.24). ABCISSE: ABC transporter, lipoprotein (LPP), DLM-family. Part of the ABC transporter complex metNIQ involved in methionine import. The complex is composed of two ATP- binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ); methionine ABC transporter substrate-binding protein MetQ 2440660..2441508 Arthrobacter arilaitensis Re117 9794073 YP_003917334.1 CDS hemL NC_014550.1 2441685 2442992 R involved in the second step of porphyrin biosynthesis, via the C5 pathway by transfering the amino group on carbon 2 of glutamate-1- semialdehyde to the neighbouring carbon, to give delta-aminolevulinic acid; glutamate-1-semialdehyde 2,1-aminomutase complement(2441685..2442992) Arthrobacter arilaitensis Re117 9794078 YP_003917335.1 CDS hemB NC_014550.1 2442998 2443981 R catalyzes the second step in the biosynthesis of heme, the condensation of two molecules of 5- aminolevulinate to form porphobilinogen: 2 5- aminolevulinate <=> porphobilinogen + 2 H(2)O; porphobilinogen synthase complement(2442998..2443981) Arthrobacter arilaitensis Re117 9793959 YP_003917336.1 CDS hemD NC_014550.1 2444044 2444835 R uroporphyrinogen-III synthase catalyses the following reaction: hydroxymethylbilane <=> uroporphyrinogen III + H(2)O; uroporphyrinogen-III synthase complement(2444044..2444835) Arthrobacter arilaitensis Re117 9793949 YP_003917337.1 CDS hemC NC_014550.1 2444845 2445819 R involved in the biosynthesis of porphyrins and related macrocycles, catalyzes the assembly of four porphobilinogen (PBG) units in a head to tail fashion to form hydroxymethylbilane: 4 porphobilinogen + H2O <=> hydroxymethylbilane + 4 NH3; hydroxymethylbilane synthase complement(2444845..2445819) Arthrobacter arilaitensis Re117 9793951 YP_003917338.1 CDS hemH NC_014550.1 2445816 2447021 R catalyzes the last step in heme biosynthesis: the chelation of a ferrous ion to proto-porphyrin IX, to form protoheme: Protoheme + 2 H+ <=> protoporphyrin + Fe2+; ferrochelatase complement(2445816..2447021) Arthrobacter arilaitensis Re117 9793950 YP_003917339.1 CDS AARI_21480 NC_014550.1 2447018 2447737 R chlorite dismutase family protein complement(2447018..2447737) Arthrobacter arilaitensis Re117 9793957 YP_003917340.1 CDS hemG NC_014550.1 2447797 2449389 R catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX: protoporphyrinogen-IX + 1.5 O(2) <=> protoporphyrin-IX + 3 H(2)O. Also oxidizes the pathway intermediate coproporphyrinogen III: coproporphyrinogen-III + O2 <=> coproporphyrin-III + H2O; protoporphyrinogen oxidase complement(2447797..2449389) Arthrobacter arilaitensis Re117 9794774 YP_003917341.1 CDS hemE NC_014550.1 2449496 2450551 R fifth enzyme of the heme biosynthetic pathway, catalyzes the sequential decarboxylation of the four acetyl side chains of uroporphyrinogen to yield coproporphyrinogen: Uroporphyrinogen III <=> coproporphyrinogen + 4 CO(2) and uroporphyrinogen I <=> coproporphyrinogen I + CO2; uroporphyrinogen decarboxylase complement(2449496..2450551) Arthrobacter arilaitensis Re117 9793955 YP_003917342.1 CDS hemA NC_014550.1 2450700 2452019 D catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA): L-glutamate 1- semialdehyde + NADP+ + tRNA(Glu) <=>L-glutamyl-tRNA(Glu) + NADPH; glutamyl-tRNA reductase 2450700..2452019 Arthrobacter arilaitensis Re117 9793953 YP_003917343.1 CDS AARI_21520 NC_014550.1 2452158 2452781 D match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator 2452158..2452781 Arthrobacter arilaitensis Re117 9793948 YP_003917344.1 CDS AARI_21530 NC_014550.1 2452846 2453067 D hypothetical protein 2452846..2453067 Arthrobacter arilaitensis Re117 9794775 YP_003917345.1 CDS AARI_21540 NC_014550.1 2453223 2454635 D exoribonuclease II catalyses the exonucleolytic cleavage in the 3- to 5-direction to yield nucleoside 5- phosphates. It is involved in mRNA degradation and tRNA precursor end processing; exoribonuclease II 2453223..2454635 Arthrobacter arilaitensis Re117 9794776 YP_003917346.1 CDS AARI_21550 NC_014550.1 2454900 2456516 D DEAD box helicase. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression; ATP-dependent RNA helicase 2454900..2456516 Arthrobacter arilaitensis Re117 9794777 YP_003917347.1 CDS AARI_21560 NC_014550.1 2456568 2457494 D match to PF01555. This domain is found in DNA methylases. In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes. This family contains both N-4 cytosine-specific DNA methylases (EC 2.1.1.113) and N-6 Adenine-specific DNA methylases (2.1.1.72); site-specific DNA-methyltransferase 2456568..2457494 Arthrobacter arilaitensis Re117 9794778 YP_003917348.1 CDS AARI_21570 NC_014550.1 2457464 2458309 R match to PF02811. The PHP (Polymerase and Histidinol Phosphatase) domain is a phosphoesterase domain; PHP domain-containing protein complement(2457464..2458309) Arthrobacter arilaitensis Re117 9794779 YP_003917349.1 CDS pepP NC_014550.1 2458375 2459922 D responsible for the release of any N-terminal amino acid adjacent to a proline residue; Xaa-Pro aminopeptidase 2458375..2459922 Arthrobacter arilaitensis Re117 9794780 YP_003917350.1 CDS AARI_21590 NC_014550.1 2460030 2460944 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2460030..2460944) Arthrobacter arilaitensis Re117 9794195 YP_003917351.1 CDS AARI_21600 NC_014550.1 2461089 2462327 D match to PF00571 (CBS domain pair); CBS domain-containing protein 2461089..2462327 Arthrobacter arilaitensis Re117 9794781 YP_003917352.1 CDS AARI_21610 NC_014550.1 2462373 2462981 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2462373..2462981 Arthrobacter arilaitensis Re117 9794782 YP_003917353.1 CDS AARI_21620 NC_014550.1 2462985 2464088 D hypothetical protein 2462985..2464088 Arthrobacter arilaitensis Re117 9794783 YP_003917354.1 CDS tatB NC_014550.1 2464101 2464505 R the twin-arginine translocation system is a Sec- independent exporter for folded proteins, often with a redox cofactor already bound, across the bacterial inner membrane; twin-arginine translocation protein TatB complement(2464101..2464505) Arthrobacter arilaitensis Re117 9794784 YP_003917355.1 CDS AARI_21640 NC_014550.1 2464583 2465167 R match to protein family TIGR02937. Sigma-70 family; RNA polymerase sigma factor complement(2464583..2465167) Arthrobacter arilaitensis Re117 9794426 YP_003917356.1 CDS AARI_21650 NC_014550.1 2465339 2466004 D match to PF01596. This family includes catechol o- methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production; O-methyltransferase 2465339..2466004 Arthrobacter arilaitensis Re117 9794785 YP_003917357.1 CDS AARI_21660 NC_014550.1 2466096 2466263 R hypothetical protein complement(2466096..2466263) Arthrobacter arilaitensis Re117 9794786 YP_003917358.1 CDS AARI_21670 NC_014550.1 2466387 2466731 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.848) with cleavage site probability 0.238 between position 22 and 23; hypothetical protein complement(2466387..2466731) Arthrobacter arilaitensis Re117 9794787 YP_003917359.1 CDS AARI_21680 NC_014550.1 2466735 2467520 R match to protein family PF03641: Possible lysine decarboxylase. The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear; hypothetical protein complement(2466735..2467520) Arthrobacter arilaitensis Re117 9794788 YP_003917360.1 CDS gluA NC_014550.1 2467656 2468429 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family, glutamate porter (TC 3.A.1.3.9). ABCISSE: ABC transporter, ATP- binding protein (ABC), PAO-family (polar amino acid and opines). Part of the ABC transporter complex gluABCD involved in glutamate import; glutamate ABC transporter ATP-binding subunit GluA 2467656..2468429 Arthrobacter arilaitensis Re117 9794789 YP_003917361.1 CDS gluB NC_014550.1 2468461 2469291 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family, glutamate porter (TC 3.A.1.3.9). ABCISSE: ABC transporter, binding protein (BP), PAO-family (polar amino acid and opines). Part of the ABC transporter complex gluABCD involved in glutamate import; glutamate ABC transporter substrate-binding protein GluB 2468461..2469291 Arthrobacter arilaitensis Re117 9793921 YP_003917362.1 CDS gluC NC_014550.1 2469431 2470108 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family, glutamate porter (TC 3.A.1.3.9). ABCISSE: ABC transporter, permease (IM), PAO-family (polar amino acid and opines). Part of the ABC transporter complex gluABCD involved in glutamate import; glutamate ABC transporter inner membrane subunit GluC 2469431..2470108 Arthrobacter arilaitensis Re117 9793922 YP_003917363.1 CDS gluD NC_014550.1 2470105 2471016 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family, glutamate porter (TC 3.A.1.3.9). ABCISSE: ABC transporter, permease (IM), PAO-family (polar amino acid and opines). Part of the ABC transporter complex gluABCD involved in glutamate import; glutamate ABC transporter inner membrane subunit GluD 2470105..2471016 Arthrobacter arilaitensis Re117 9793923 YP_003917364.1 CDS dapE NC_014550.1 2471110 2472186 R catalyzes the fifth step in the biosynthesis of lysine from aspartate semialdehyde: the hydrolysis of succinyl-diaminopimelate to diaminopimelate and succinate; succinyl-diaminopimelate desuccinylase complement(2471110..2472186) Arthrobacter arilaitensis Re117 9793924 YP_003917365.1 CDS dapD NC_014550.1 2472268 2473221 D involved in the biosynthesis of diaminopimelate and lysine from aspartate semialdehyde (EC 2.3.1.117); 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase 2472268..2473221 Arthrobacter arilaitensis Re117 9793792 YP_003917366.1 CDS AARI_21750 NC_014550.1 2473285 2473893 R hypothetical protein complement(2473285..2473893) Arthrobacter arilaitensis Re117 9793791 YP_003917367.1 CDS gltA NC_014550.1 2474035 2475321 R catalyzes the synthesis of citrate from oxaloacetate and acetyl-CoA. Involved in TCA cycle; citrate synthase complement(2474035..2475321) Arthrobacter arilaitensis Re117 9794790 YP_003917368.1 CDS dapC NC_014550.1 2475420 2476535 R catalyzes the formation of N-succinyl-LL-2,6- diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; succinyldiaminopimelate transaminase complement(2475420..2476535) Arthrobacter arilaitensis Re117 9793917 YP_003917369.1 CDS AARI_21780 NC_014550.1 2476548 2476871 R match to protein domain PF00037: 4Fe-4S binding domain. Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases; 4Fe-4S ferredoxin domain-containing protein complement(2476548..2476871) Arthrobacter arilaitensis Re117 9793790 YP_003917370.1 CDS AARI_21790 NC_014550.1 2477086 2477328 D hypothetical protein 2477086..2477328 Arthrobacter arilaitensis Re117 9794791 YP_003917371.1 CDS AARI_21800 NC_014550.1 2477452 2477961 D identified by match to PF01022. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator 2477452..2477961 Arthrobacter arilaitensis Re117 9794792 YP_003917372.1 CDS AARI_21810 NC_014550.1 2478032 2478463 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2478032..2478463) Arthrobacter arilaitensis Re117 9794793 YP_003917373.1 CDS typA NC_014550.1 2478444 2480351 R match to protein family TIGR01394. This bacterial (and Arabidopsis) protein, termed TypA or BipA, a GTP- binding protein, is phosphorylated on a tyrosine residue under some cellular conditions. Mutants show altered regulation of some pathways, but the precise function is unknown; GTP-binding protein TypA complement(2478444..2480351) Arthrobacter arilaitensis Re117 9794794 YP_003917374.1 CDS AARI_21830 NC_014550.1 2480499 2481041 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2480499..2481041) Arthrobacter arilaitensis Re117 9794484 YP_003917375.1 CDS thiF NC_014550.1 2481073 2482218 R catalyzes the adenylation by ATP of the carboxyl- terminal glycine of ThiS, as part of the biosynthesis pathway of thiamin pyrophosphate (vitamin B1); adenylyltransferase ThiF complement(2481073..2482218) Arthrobacter arilaitensis Re117 9794795 YP_003917376.1 CDS thiG NC_014550.1 2482215 2483036 R involved in the formation of the thiazole moiety of thiamin pyrophosphate: catalyzes the formation of thiazole from 1-deoxy-D-xylulose 5-phosphate (DXP) and dehydroglycine, with the help of the sulfur carrier protein ThiS; thiazole synthase complement(2482215..2483036) Arthrobacter arilaitensis Re117 9794442 YP_003917377.1 CDS thiS NC_014550.1 2483039 2483299 R sulfur carrier protein involved in thiamin biosynthesis : carries the sulfur needed for thiazole assembly on its carboxy terminus (ThiS-COSH); thiamin synthesis protein ThiS complement(2483039..2483299) Arthrobacter arilaitensis Re117 9794443 YP_003917378.1 CDS thiO NC_014550.1 2483300 2484412 R required for the biosynthesis of the thiazole moiety of thiamine diphosphate; glycine oxidase complement(2483300..2484412) Arthrobacter arilaitensis Re117 9794447 YP_003917379.1 CDS AARI_21880 NC_014550.1 2484594 2485559 D N-terminal section of the protein: RNaseH. C-terminal section of the protein: GNAT-family acetyltransferase; hypothetical protein 2484594..2485559 Arthrobacter arilaitensis Re117 9794446 YP_003917380.1 CDS AARI_21890 NC_014550.1 2485643 2486863 R 9 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2485643..2486863) Arthrobacter arilaitensis Re117 9794796 YP_003917381.1 CDS AARI_21900 NC_014550.1 2487159 2487590 R identified by match to protein family PF02566: OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress-induced protein found in Escherichia coli. This family also contains an organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation; OsmC-like protein complement(2487159..2487590) Arthrobacter arilaitensis Re117 9794797 YP_003917382.1 CDS AARI_21910 NC_014550.1 2487622 2488056 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2487622..2488056) Arthrobacter arilaitensis Re117 9794798 YP_003917383.1 CDS AARI_21920 NC_014550.1 2488124 2488957 R match to PF00561: alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; hydrolase complement(2488124..2488957) Arthrobacter arilaitensis Re117 9794799 YP_003917384.1 CDS AARI_21930 NC_014550.1 2488948 2489667 R 6 transmembrane helices predicted by TMHMM2.0. Match to PF07947. The members of this family are similar to the hypothetical protein yhhN expressed by E. coli. Many of the members of this family are annotated as being possible transmembrane proteins, and in fact they all have a high proportion of hydrophobic residues; YhhN-like protein complement(2488948..2489667) Arthrobacter arilaitensis Re117 9794800 YP_003917385.1 CDS AARI_21940 NC_014550.1 2489710 2490390 R match to protein family PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein complement(2489710..2490390) Arthrobacter arilaitensis Re117 9794801 YP_003917386.1 CDS AARI_21950 NC_014550.1 2490720 2490848 D hypothetical protein 2490720..2490848 Arthrobacter arilaitensis Re117 9794802 YP_003917387.1 CDS AARI_21960 NC_014550.1 2490869 2491003 R hypothetical protein complement(2490869..2491003) Arthrobacter arilaitensis Re117 9794803 YP_003917388.1 CDS AARI_21970 NC_014550.1 2491164 2492051 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2491164..2492051 Arthrobacter arilaitensis Re117 9794804 YP_003917389.1 CDS AARI_21980 NC_014550.1 2492048 2492542 D hypothetical protein 2492048..2492542 Arthrobacter arilaitensis Re117 9794805 YP_003917390.1 CDS AARI_21990 NC_014550.1 2492539 2493276 R 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2492539..2493276) Arthrobacter arilaitensis Re117 9794806 YP_003917391.1 CDS AARI_22000 NC_014550.1 2493421 2493852 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2493421..2493852 Arthrobacter arilaitensis Re117 9794807 YP_003917392.1 CDS AARI_22010 NC_014550.1 2493858 2494145 D transcriptional regulator 2493858..2494145 Arthrobacter arilaitensis Re117 9794808 YP_003917393.1 CDS AARI_22020 NC_014550.1 2494183 2494800 D hypothetical protein 2494183..2494800 Arthrobacter arilaitensis Re117 9794809 YP_003917394.1 CDS AARI_22030 NC_014550.1 2494797 2495879 R permease complement(2494797..2495879) Arthrobacter arilaitensis Re117 9794810 YP_003917395.1 CDS AARI_22040 NC_014550.1 2495938 2496699 R hypothetical protein complement(2495938..2496699) Arthrobacter arilaitensis Re117 9794811 YP_003917396.1 CDS AARI_22050 NC_014550.1 2496806 2497306 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2496806..2497306) Arthrobacter arilaitensis Re117 9794812 YP_003917397.1 CDS AARI_22060 NC_014550.1 2497335 2497721 R match to protein family PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein complement(2497335..2497721) Arthrobacter arilaitensis Re117 9794813 YP_003917398.1 CDS AARI_22070 NC_014550.1 2497771 2498310 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2497771..2498310) Arthrobacter arilaitensis Re117 9794814 YP_003917399.1 CDS AARI_22080 NC_014550.1 2498494 2498787 D hypothetical protein 2498494..2498787 Arthrobacter arilaitensis Re117 9794815 YP_003917400.1 CDS pgsA NC_014550.1 2498966 2499544 D involved in phospholipid biosynthesis; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2498966..2499544 Arthrobacter arilaitensis Re117 9794816 YP_003917401.1 CDS AARI_22100 NC_014550.1 2499559 2500065 R match to PF02834. Corresponds to a number of known and predicted phosphoesterases, including bacterial and archaeal 2 ,5 RNA ligases. The physiological substrate(s) in prokaryotes may include small 2 ,5 -link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles; 2',5' RNA ligase family protein complement(2499559..2500065) Arthrobacter arilaitensis Re117 9794202 YP_003917402.1 CDS AARI_22110 NC_014550.1 2500065 2500616 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2500065..2500616) Arthrobacter arilaitensis Re117 9794817 YP_003917403.1 CDS AARI_22120 NC_014550.1 2500636 2501361 R identified by match to protein domain PF08241; SAM-dependent methyltransferase complement(2500636..2501361) Arthrobacter arilaitensis Re117 9794818 YP_003917404.1 CDS fadA NC_014550.1 2501623 2502771 D acetyl-CoA C-acyltransferase (also named 3-ketoacyl- CoA thiolase or thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation; acetyl-CoA C-acyltransferase 2501623..2502771 Arthrobacter arilaitensis Re117 9794819 YP_003917405.1 CDS AARI_22140 NC_014550.1 2502796 2504388 D long-chain-fatty-acid--CoA ligase activates long- chain fatty acids for both the synthesis of cellular lipids and their degradation via beta-oxidation; long-chain-fatty-acid--CoA ligase 2502796..2504388 Arthrobacter arilaitensis Re117 9793843 YP_003917406.1 CDS AARI_22150 NC_014550.1 2504385 2505584 D possibly involved in the metabolism of lipids. Match to protein domains PF08028, PF02771 and PF02770. Acyl-CoA dehydrogenases catalyze the alpha,beta- dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase 2504385..2505584 Arthrobacter arilaitensis Re117 9794820 YP_003917407.1 CDS AARI_22160 NC_014550.1 2505650 2506114 D hypothetical protein 2505650..2506114 Arthrobacter arilaitensis Re117 9794821 YP_003917408.1 CDS AARI_22170 NC_014550.1 2506127 2506978 R identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase complement(2506127..2506978) Arthrobacter arilaitensis Re117 9794822 YP_003917409.1 CDS AARI_22180 NC_014550.1 2507008 2507973 R identified by match to protein family PF00849. Pseudouridylate synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5- ribosyluracil, psi); pseudouridylate synthase complement(2507008..2507973) Arthrobacter arilaitensis Re117 9794823 YP_003917410.1 CDS AARI_22190 NC_014550.1 2508193 2508747 R 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2508193..2508747) Arthrobacter arilaitensis Re117 9794824 YP_003917411.1 CDS AARI_22200 NC_014550.1 2509009 2509476 D hypothetical protein 2509009..2509476 Arthrobacter arilaitensis Re117 9794825 YP_003917412.1 CDS AARI_22210 NC_014550.1 2509504 2509668 R hypothetical protein complement(2509504..2509668) Arthrobacter arilaitensis Re117 9794826 YP_003917413.1 CDS AARI_22220 NC_014550.1 2509794 2510477 D identified by match to protein domain PF00300; phosphoglycerate mutase family protein 2509794..2510477 Arthrobacter arilaitensis Re117 9794827 YP_003917414.1 CDS AARI_22230 NC_014550.1 2510488 2511027 D hypothetical protein 2510488..2511027 Arthrobacter arilaitensis Re117 9794828 YP_003917415.1 CDS AARI_22240 NC_014550.1 2511024 2511791 D match to protein family PF00454. This domain is present in a wide range of protein kinases, involved in diverse cellular functions; phosphatidylinositol 3-and 4-kinase family protein 2511024..2511791 Arthrobacter arilaitensis Re117 9794829 YP_003917416.1 CDS AARI_22250 NC_014550.1 2511813 2512442 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2511813..2512442) Arthrobacter arilaitensis Re117 9794830 YP_003917417.1 CDS AARI_22260 NC_014550.1 2512614 2513309 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein 2512614..2513309 Arthrobacter arilaitensis Re117 9794831 YP_003917418.1 CDS AARI_22270 NC_014550.1 2513405 2514244 D match to PF00561: alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; hydrolase 2513405..2514244 Arthrobacter arilaitensis Re117 9794832 YP_003917419.1 CDS AARI_22280 NC_014550.1 2514292 2514678 D hypothetical protein 2514292..2514678 Arthrobacter arilaitensis Re117 9794833 YP_003917420.1 CDS AARI_22290 NC_014550.1 2514863 2515156 D hypothetical protein 2514863..2515156 Arthrobacter arilaitensis Re117 9794834 YP_003917421.1 CDS AARI_22300 NC_014550.1 2515177 2515410 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2515177..2515410) Arthrobacter arilaitensis Re117 9794835 YP_003917422.1 CDS AARI_22310 NC_014550.1 2515742 2516731 R match to protein domain PF02861: Clp amino terminal domain. This short domain is found in one or two copies at the amino terminus of ClpA and ClpB proteins from bacteria and eukaryotes. The function of these domains is uncertain but they may form a protein binding site. The proteins are thought to be subunits of ATP-dependent proteases which act as chaperones to target the proteases to substrates; hypothetical protein complement(2515742..2516731) Arthrobacter arilaitensis Re117 9794836 YP_003917423.1 CDS AARI_22320 NC_014550.1 2516728 2516973 R possible DNA-binding protein. Match to protein domain IPR009057: homeodomain-like; hypothetical protein complement(2516728..2516973) Arthrobacter arilaitensis Re117 9794837 YP_003917424.1 CDS AARI_22330 NC_014550.1 2518415 2518561 D hypothetical protein 2518415..2518561 Arthrobacter arilaitensis Re117 9793484 YP_003917425.1 CDS dld NC_014550.1 2518744 2520459 R catalyses the conversion of D-lactate to pyruvate. Probable quinone-dependent lactate dehydrogenase, functionning when lactate is used as a carbon and energy source; D-lactate dehydrogenase complement(2518744..2520459) Arthrobacter arilaitensis Re117 9794839 YP_003917426.1 CDS AARI_22350 NC_014550.1 2520838 2521728 R match to PF01555. This domain is found in DNA methylases. In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes. Match to PS00092 pattern: N-6 Adenine- specific DNA methylases signature; site-specific DNA-methyltransferase (adenine specific) complement(2520838..2521728) Arthrobacter arilaitensis Re117 9793819 YP_003917427.1 CDS AARI_35440 NC_014550.1 2521909 2522988 R transposase of ISAar18, IS110 family complement(2521909..2522988) Arthrobacter arilaitensis Re117 9794840 YP_003917428.1 CDS AARI_35450 NC_014550.1 2523435 2524631 D transposase of ISAar17, IS110 family 2523435..2524631 Arthrobacter arilaitensis Re117 9793485 YP_003917429.1 CDS AARI_22360 NC_014550.1 2524628 2524858 D hypothetical protein 2524628..2524858 Arthrobacter arilaitensis Re117 9793486 YP_003917430.1 CDS AARI_22370 NC_014550.1 2524892 2525995 R identified by match to protein family TIGR00092: GTP-binding protein YchF; translation-associated GTPase complement(2524892..2525995) Arthrobacter arilaitensis Re117 9794841 YP_003917431.1 CDS ispH NC_014550.1 2526074 2527159 R forms part of the non-mevalonate pathway for terpenoid biosynthesis; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase complement(2526074..2527159) Arthrobacter arilaitensis Re117 9794842 YP_003917432.1 CDS xseA NC_014550.1 2527365 2528627 D exodeoxyribonuclease VII catalyses the exonucleolytic cleavage in either 5 - to 3 - or 3 - to 5 - direction to yield nucleoside 5-phosphates. In E. coli, ExoVII plays a role in methyl-directed mismatch repair in vivo. ExoVII may also guard the genome from mutagenesis by removing excess ssDNA, since the build up of ssDNA would lead to SOS induction and PolIV-dependent mutagenesis; exodeoxyribonuclease VII large subunit 2527365..2528627 Arthrobacter arilaitensis Re117 9794014 YP_003917433.1 CDS xseB NC_014550.1 2528656 2528886 D exodeoxyribonuclease VII catalyses the exonucleolytic cleavage in either 5 - to 3 - or 3 - to 5 - direction to yield nucleoside 5-phosphates. In E. coli, ExoVII plays a role in methyl-directed mismatch repair in vivo. ExoVII may also guard the genome from mutagenesis by removing excess ssDNA, since the build up of ssDNA would lead to SOS induction and PolIV-dependent mutagenesis; exodeoxyribonuclease VII small subunit 2528656..2528886 Arthrobacter arilaitensis Re117 9794509 YP_003917434.1 CDS AARI_22410 NC_014550.1 2528907 2529770 R identified by match to protein domain PF03976. This domain is about 230 amino acids in length and has polyphosphate kinase activity; polyphosphate kinase domain-containing protein complement(2528907..2529770) Arthrobacter arilaitensis Re117 9794510 YP_003917435.1 CDS AARI_22420 NC_014550.1 2529800 2529958 D hypothetical protein 2529800..2529958 Arthrobacter arilaitensis Re117 9794843 YP_003917436.1 CDS alaT NC_014550.1 2530052 2531272 R catalyses the following reaction: L-alanine + 2- oxoglutarate <=> pyruvate + L-glutamate; alanine transaminase complement(2530052..2531272) Arthrobacter arilaitensis Re117 9794844 YP_003917437.1 CDS AARI_22440 NC_014550.1 2531365 2532270 R match to PS51257: prokaryotic membrane lipoprotein lipid attachment site profile; hypothetical protein complement(2531365..2532270) Arthrobacter arilaitensis Re117 9793661 YP_003917438.1 CDS AARI_22450 NC_014550.1 2532423 2532782 R identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase complement(2532423..2532782) Arthrobacter arilaitensis Re117 9794845 YP_003917439.1 CDS AARI_22460 NC_014550.1 2532895 2533401 D identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator 2532895..2533401 Arthrobacter arilaitensis Re117 9794846 YP_003917440.1 CDS AARI_22470 NC_014550.1 2533474 2534307 R hypothetical protein complement(2533474..2534307) Arthrobacter arilaitensis Re117 9794847 YP_003917441.1 CDS AARI_22480 NC_014550.1 2534488 2535108 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2534488..2535108) Arthrobacter arilaitensis Re117 9794848 YP_003917442.1 CDS AARI_22490 NC_014550.1 2535194 2535808 D catalyses the following reaction: ATP + 5- formyltetrahydrofolate => ADP + phosphate + 5,10- methenyltetrahydrofolate; 5-formyltetrahydrofolate cyclo-ligase 2535194..2535808 Arthrobacter arilaitensis Re117 9794849 YP_003917443.1 CDS AARI_22500 NC_014550.1 2535870 2536580 D hypothetical protein 2535870..2536580 Arthrobacter arilaitensis Re117 9794850 YP_003917444.1 CDS AARI_22510 NC_014550.1 2536583 2536900 R hypothetical protein complement(2536583..2536900) Arthrobacter arilaitensis Re117 9794851 YP_003917445.1 CDS AARI_22520 NC_014550.1 2536900 2541174 R hypothetical protein complement(2536900..2541174) Arthrobacter arilaitensis Re117 9794852 YP_003917446.1 CDS AARI_22530 NC_014550.1 2541383 2541913 R hypothetical protein complement(2541383..2541913) Arthrobacter arilaitensis Re117 9794853 YP_003917447.1 CDS guaA NC_014550.1 2542091 2543677 R catalyzes the ATP-dependent formation of GMP from xanthosine 5-phosphate and glutamine; GMP synthase (glutamine-hydrolyzing) complement(2542091..2543677) Arthrobacter arilaitensis Re117 9794854 YP_003917448.1 CDS AARI_22550 NC_014550.1 2543825 2544289 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2543825..2544289) Arthrobacter arilaitensis Re117 9793940 YP_003917449.1 CDS AARI_22560 NC_014550.1 2544340 2545149 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.976) with cleavage site probability 0.602 between position 37 and 38; hypothetical protein complement(2544340..2545149) Arthrobacter arilaitensis Re117 9794855 YP_003917450.1 CDS guaB NC_014550.1 2545325 2546476 R catalyzes the NAD-dependent oxidation of IMP to XMP. Involved in the de novo synthesis of the guanine nucleotides; IMP dehydrogenase complement(2545325..2546476) Arthrobacter arilaitensis Re117 9794856 YP_003917451.1 CDS AARI_22580 NC_014550.1 2546651 2547967 R hypothetical protein complement(2546651..2547967) Arthrobacter arilaitensis Re117 9793941 YP_003917452.1 CDS AARI_22590 NC_014550.1 2548217 2548771 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.7762 between position 29 and 30; hypothetical protein 2548217..2548771 Arthrobacter arilaitensis Re117 9794857 YP_003917453.1 CDS guaB NC_014550.1 2548968 2550473 R catalyzes the NAD-dependent oxidation of IMP to XMP. Involved in the de novo synthesis of the guanine nucleotides; IMP dehydrogenase complement(2548968..2550473) Arthrobacter arilaitensis Re117 9794858 YP_003917454.1 CDS AARI_22610 NC_014550.1 2550594 2552690 R match to protein domain PF01757. This family includes a range of acyltransferase enzymes. 11 transmembrane helices predicted by TMHMM2.0; acyltransferase domain-containing membrane protein complement(2550594..2552690) Arthrobacter arilaitensis Re117 9793942 YP_003917455.1 CDS AARI_22620 NC_014550.1 2552926 2553108 D hypothetical protein 2552926..2553108 Arthrobacter arilaitensis Re117 9794859 YP_003917456.1 CDS groEL NC_014550.1 2553121 2554722 R chaperonins are involved in productive folding of proteins. With the aid of cochaperonin GroES, GroEL encapsulates non-native substrate proteins inside the cavity of the GroEL-ES complex and promotes folding by using energy derived from ATP hydrolysis; chaperonin GroEL complement(2553121..2554722) Arthrobacter arilaitensis Re117 9794860 YP_003917457.1 CDS groES NC_014550.1 2554756 2555052 R cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts; co-chaperonin GroES complement(2554756..2555052) Arthrobacter arilaitensis Re117 9793937 YP_003917458.1 CDS lysP NC_014550.1 2555244 2556680 R amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family, lysine:H+ symporter (TC 2.A.3.1.2). Identified by similarity to protein SP:P25737 (Escherichia coli); lysine-specific permease complement(2555244..2556680) Arthrobacter arilaitensis Re117 9793938 YP_003917459.1 CDS AARI_22660 NC_014550.1 2557270 2558511 D hypothetical protein 2557270..2558511 Arthrobacter arilaitensis Re117 9794053 YP_003917460.1 CDS AARI_22670 NC_014550.1 2558669 2559811 D possible glutamate--cysteine ligase (6.3.2.2). Match to protein family PF04107: glutamate-cysteine ligase family 2(GCS2); carboxylate-amine ligase 2558669..2559811 Arthrobacter arilaitensis Re117 9794861 YP_003917461.1 CDS AARI_22680 NC_014550.1 2560244 2560972 D hypothetical protein 2560244..2560972 Arthrobacter arilaitensis Re117 9794862 YP_003917462.1 CDS AARI_22690 NC_014550.1 2561203 2562015 R hypothetical protein complement(2561203..2562015) Arthrobacter arilaitensis Re117 9794863 YP_003917463.1 CDS AARI_22700 NC_014550.1 2562053 2564092 R hypothetical protein complement(2562053..2564092) Arthrobacter arilaitensis Re117 9794864 YP_003917464.1 CDS AARI_22710 NC_014550.1 2564461 2565135 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(2564461..2565135) Arthrobacter arilaitensis Re117 9794865 YP_003917465.1 CDS AARI_22720 NC_014550.1 2565132 2566403 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(2565132..2566403) Arthrobacter arilaitensis Re117 9794866 YP_003917466.1 CDS AARI_35460 NC_014550.1 2567037 2568344 D transposase of ISAar19, ISL3 family 2567037..2568344 Arthrobacter arilaitensis Re117 9794868 YP_003917467.1 CDS AARI_35490 NC_014550.1 2570492 2571799 D transposase of ISAar19, ISL3 family 2570492..2571799 Arthrobacter arilaitensis Re117 9793489 YP_003917468.1 CDS AARI_22770 NC_014550.1 2573924 2574253 D hypothetical protein 2573924..2574253 Arthrobacter arilaitensis Re117 9794871 YP_003917469.1 CDS AARI_35500 NC_014550.1 2575668 2576975 D transposase of ISAar19, ISL3 family 2575668..2576975 Arthrobacter arilaitensis Re117 9794873 YP_003917470.1 CDS AARI_35520 NC_014550.1 2578686 2579123 D transposase of ISAar44, IS3 family, IS3 group, orfA 2578686..2579123 Arthrobacter arilaitensis Re117 9793492 YP_003917471.1 CDS AARI_35530 NC_014550.1 2579222 2580163 D transposase of ISAar44, IS3 family, IS3 group, orfB 2579222..2580163 Arthrobacter arilaitensis Re117 9793493 YP_003917472.1 CDS AARI_22790 NC_014550.1 2582709 2583125 R hypothetical protein complement(2582709..2583125) Arthrobacter arilaitensis Re117 9793496 YP_003917473.1 CDS AARI_35560 NC_014550.1 2583430 2584866 D transposase of ISAar11, IS1380 family 2583430..2584866 Arthrobacter arilaitensis Re117 9794874 YP_003917474.1 CDS AARI_22800 NC_014550.1 2586813 2587532 R hypothetical protein complement(2586813..2587532) Arthrobacter arilaitensis Re117 9793498 YP_003917475.1 CDS hsdR NC_014550.1 2587519 2590620 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system restriction subunit complement(2587519..2590620) Arthrobacter arilaitensis Re117 9794875 YP_003917476.1 CDS hsdS NC_014550.1 2590617 2591870 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system specificity subunit complement(2590617..2591870) Arthrobacter arilaitensis Re117 9793981 YP_003917477.1 CDS hsdM NC_014550.1 2591867 2594317 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system modification subunit complement(2591867..2594317) Arthrobacter arilaitensis Re117 9793983 YP_003917478.1 CDS AARI_22840 NC_014550.1 2594988 2595539 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 2594988..2595539 Arthrobacter arilaitensis Re117 9793978 YP_003917479.1 CDS AARI_22850 NC_014550.1 2596639 2596950 R hypothetical protein complement(2596639..2596950) Arthrobacter arilaitensis Re117 9793500 YP_003917480.1 CDS AARI_22860 NC_014550.1 2597433 2598896 R glycoside hydrolase family 32 comprises enzymes with several known activities: invertase (EC 3.2.1.26); inulinase (EC 3.2.1.7); levanase (EC 3.2.1.65); exo- inulinase (EC 3.2.1.80); sucrose:sucrose 1- fructosyltransferase (EC 2.4.1.99); fructan:fructan 1- fructosyltransferase (EC 2.4.1.100); glycoside hydrolase family 32 protein complement(2597433..2598896) Arthrobacter arilaitensis Re117 9794877 YP_003917481.1 CDS AARI_22880 NC_014550.1 2599021 2599968 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit complement(2599021..2599968) Arthrobacter arilaitensis Re117 9794879 YP_003917482.1 CDS AARI_22890 NC_014550.1 2599965 2600882 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit complement(2599965..2600882) Arthrobacter arilaitensis Re117 9794880 YP_003917483.1 CDS AARI_22900 NC_014550.1 2600879 2601853 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit complement(2600879..2601853) Arthrobacter arilaitensis Re117 9794881 YP_003917484.1 CDS AARI_22910 NC_014550.1 2601859 2602836 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit complement(2601859..2602836) Arthrobacter arilaitensis Re117 9794882 YP_003917485.1 CDS AARI_22920 NC_014550.1 2602910 2604586 R TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein complement(2602910..2604586) Arthrobacter arilaitensis Re117 9794883 YP_003917486.1 CDS AARI_22930 NC_014550.1 2604480 2605655 R match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator complement(2604480..2605655) Arthrobacter arilaitensis Re117 9794884 YP_003917487.1 CDS AARI_22940 NC_014550.1 2606026 2607054 R match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator complement(2606026..2607054) Arthrobacter arilaitensis Re117 9794885 YP_003917488.1 CDS AARI_22950 NC_014550.1 2607177 2608649 D glycoside hydrolase family 32 comprises enzymes with several known activities: invertase (EC 3.2.1.26); inulinase (EC 3.2.1.7); levanase (EC 3.2.1.65); exo- inulinase (EC 3.2.1.80); sucrose:sucrose 1- fructosyltransferase (EC 2.4.1.99); fructan:fructan 1- fructosyltransferase (EC 2.4.1.100); glycoside hydrolase family 32 protein 2607177..2608649 Arthrobacter arilaitensis Re117 9794886 YP_003917489.1 CDS AARI_22960 NC_014550.1 2608646 2609551 D fructokinase catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate; fructokinase 2608646..2609551 Arthrobacter arilaitensis Re117 9794887 YP_003917490.1 CDS AARI_22970 NC_014550.1 2609591 2610889 D major facilitator superfamily, Oligosaccharide:H+ Symporter (OHS) Family (TC 2.A.1.5.z). Members of this family transport saccharides such as lactose, sucrose, raffinose and meliobiose; MFS superfamily sugar transporter 2609591..2610889 Arthrobacter arilaitensis Re117 9794888 YP_003917491.1 CDS AARI_23000 NC_014550.1 2612413 2612895 D hypothetical protein 2612413..2612895 Arthrobacter arilaitensis Re117 9794891 YP_003917492.1 CDS AARI_23010 NC_014550.1 2612930 2613124 D hypothetical protein 2612930..2613124 Arthrobacter arilaitensis Re117 9794892 YP_003917493.1 CDS gcp NC_014550.1 2613522 2614601 R hydrolyses O-sialoglycoproteins. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated; O-sialoglycoprotein endopeptidase complement(2613522..2614601) Arthrobacter arilaitensis Re117 9794893 YP_003917494.1 CDS AARI_23030 NC_014550.1 2614598 2615089 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2614598..2615089) Arthrobacter arilaitensis Re117 9793891 YP_003917495.1 CDS AARI_23040 NC_014550.1 2615086 2615763 R match to protein domain PF00814: glycoprotease family; glycoprotease complement(2615086..2615763) Arthrobacter arilaitensis Re117 9794894 YP_003917496.1 CDS AARI_23050 NC_014550.1 2615756 2616334 R match to protein domain PF02367: uncharacterised P- loop hydrolase UPF0079. These proteins are probably essential to bacteria as members are found in all genomes so far sequenced and no equivalent genes have been found in the archaea and eukaryotes, suggesting a role in cell wall biosynthesis; ATP-binding protein complement(2615756..2616334) Arthrobacter arilaitensis Re117 9794895 YP_003917497.1 CDS alr NC_014550.1 2616327 2617526 R catalyzes the pyridoxal-dependent conversion of L- alanine into D-alanine, a key building block of bacterial peptidoglycan; alanine racemase complement(2616327..2617526) Arthrobacter arilaitensis Re117 9794896 YP_003917498.1 CDS AARI_23070 NC_014550.1 2617673 2618044 R Large Conductance Mechanosensitive Ion Channel (MscL) Family (TC 1.A.22.1.z). This type of protein forms a nonselective ion channel; large conductance mechanosensitive channel protein complement(2617673..2618044) Arthrobacter arilaitensis Re117 9793664 YP_003917499.1 CDS coaA NC_014550.1 2618181 2619140 R catalyzes the phosphorylation of pantothenic acid to form 4-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway; pantothenate kinase complement(2618181..2619140) Arthrobacter arilaitensis Re117 9794897 YP_003917500.1 CDS glmS NC_014550.1 2619308 2621179 D catalyses the formation of D-glucosamine 6- phosphate from D-fructose 6-phosphate. It is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being a step in the pathway for UDP-N-acetylglucosamine biosynthesis; glutamine--fructose-6-phosphate transaminase 2619308..2621179 Arthrobacter arilaitensis Re117 9793747 YP_003917501.1 CDS acpS NC_014550.1 2621268 2621618 D catalyses the following reaction: CoA-(4- phosphopantetheine) + apo-ACP => adenosine 3,5-bisphosphate + holo-ACP. All polyketide synthases, fatty-acid synthases and non- ribosomal peptide synthases require post-translational modification of their constituent ACP (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain; holo-ACP synthase 2621268..2621618 Arthrobacter arilaitensis Re117 9793904 YP_003917502.1 CDS AARI_23110 NC_014550.1 2621702 2623228 D match to protein domain PF01256: carbohydrate kinase; hypothetical protein 2621702..2623228 Arthrobacter arilaitensis Re117 9793653 YP_003917503.1 CDS AARI_23120 NC_014550.1 2623306 2624676 R catalyses the formation of UDP-glucuronate from UDP- glucose; UDP-glucose 6-dehydrogenase complement(2623306..2624676) Arthrobacter arilaitensis Re117 9794898 YP_003917504.1 CDS glmM NC_014550.1 2624826 2626172 R catalyses the formation of D-glucosamine 1- phosphate from D-glucosamine 6-phosphate. It is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis; phosphoglucosamine mutase complement(2624826..2626172) Arthrobacter arilaitensis Re117 9794899 YP_003917505.1 CDS rpsI NC_014550.1 2626343 2626843 R ribosomal protein S9 is one of the proteins from the small ribosomal subunit; 30S ribosomal protein S9 complement(2626343..2626843) Arthrobacter arilaitensis Re117 9793903 YP_003917506.1 CDS rplM NC_014550.1 2626882 2627325 R this protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly; 50S ribosomal protein L13 complement(2626882..2627325) Arthrobacter arilaitensis Re117 9794356 YP_003917507.1 CDS truA NC_014550.1 2627651 2628586 R formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; tRNA pseudouridylate synthase A complement(2627651..2628586) Arthrobacter arilaitensis Re117 9794320 YP_003917508.1 CDS AARI_23170 NC_014550.1 2628841 2629281 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.720 between position 29 and 30; hypothetical protein 2628841..2629281 Arthrobacter arilaitensis Re117 9794476 YP_003917509.1 CDS AARI_23180 NC_014550.1 2629589 2630029 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.431 between position 29 and 30; hypothetical protein 2629589..2630029 Arthrobacter arilaitensis Re117 9794900 YP_003917510.1 CDS AARI_23190 NC_014550.1 2630042 2630158 D hypothetical protein 2630042..2630158 Arthrobacter arilaitensis Re117 9794901 YP_003917511.1 CDS rplQ NC_014550.1 2630155 2630601 R part of the 50S ribosomal subunit. Contacts protein L32; 50S ribosomal protein L17 complement(2630155..2630601) Arthrobacter arilaitensis Re117 9794902 YP_003917512.1 CDS rpoA NC_014550.1 2630685 2631686 R DNA-directed RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; DNA-directed RNA polymerase subunit alpha complement(2630685..2631686) Arthrobacter arilaitensis Re117 9794324 YP_003917513.1 CDS rpsK NC_014550.1 2631857 2632258 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; 30S ribosomal protein S11 complement(2631857..2632258) Arthrobacter arilaitensis Re117 9794342 YP_003917514.1 CDS rpsM NC_014550.1 2632302 2632676 R part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome; 30S ribosomal protein S13 complement(2632302..2632676) Arthrobacter arilaitensis Re117 9794358 YP_003917515.1 CDS rpmJ NC_014550.1 2632825 2632938 R ribosomal protein L36 is the smallest protein from the large subunit of the prokaryotic ribosome; 50S ribosomal protein L36 complement(2632825..2632938) Arthrobacter arilaitensis Re117 9794360 YP_003917516.1 CDS infA NC_014550.1 2633066 2633287 R translation initiation factor IF-1 complement(2633066..2633287) Arthrobacter arilaitensis Re117 9794341 YP_003917517.1 CDS map NC_014550.1 2633517 2634350 R responsible for the removal of the amino-terminal (initiator) methionine from nascent eukaryotic cytosolic and cytoplasmic prokaryotic proteins if the penultimate amino acid is small and uncharged; methionyl aminopeptidase complement(2633517..2634350) Arthrobacter arilaitensis Re117 9794008 YP_003917518.1 CDS adk NC_014550.1 2634497 2635069 R catalyses the following reaction: ATP + AMP <=> 2 ADP; adenylate kinase complement(2634497..2635069) Arthrobacter arilaitensis Re117 9794060 YP_003917519.1 CDS secY NC_014550.1 2635066 2636370 R identified by match to protein family PF00344. The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF); protein-export membrane protein SecY complement(2635066..2636370) Arthrobacter arilaitensis Re117 9793659 YP_003917520.1 CDS rplO NC_014550.1 2636627 2637079 R binds to the 23S rRNA. Part of the 50S ribosomal subunit; 50S ribosomal protein L15 complement(2636627..2637079) Arthrobacter arilaitensis Re117 9794391 YP_003917521.1 CDS rpmD NC_014550.1 2637082 2637288 R part of the 50S ribosomal subunit; 50S ribosomal protein L30 complement(2637082..2637288) Arthrobacter arilaitensis Re117 9794322 YP_003917522.1 CDS rpsE NC_014550.1 2637292 2638002 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; 30S ribosomal protein S5 complement(2637292..2638002) Arthrobacter arilaitensis Re117 9794336 YP_003917523.1 CDS rplR NC_014550.1 2637999 2638370 R part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs; 50S ribosomal protein L18 complement(2637999..2638370) Arthrobacter arilaitensis Re117 9794352 YP_003917524.1 CDS rplF NC_014550.1 2638373 2638909 R this protein binds to the 23S rRNA, and is important in its secondary structure. Part of the 50S ribosomal subunit; 50S ribosomal protein L6 complement(2638373..2638909) Arthrobacter arilaitensis Re117 9794325 YP_003917525.1 CDS rpsH NC_014550.1 2638930 2639328 R one of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(2638930..2639328) Arthrobacter arilaitensis Re117 9794315 YP_003917526.1 CDS rplE NC_014550.1 2639386 2639955 R part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA; 50S ribosomal protein L5 complement(2639386..2639955) Arthrobacter arilaitensis Re117 9794355 YP_003917527.1 CDS rplX NC_014550.1 2639955 2640299 R part of the 50S ribosomal subunit. One of two assembly inititator proteins, it binds directly to the 5 prime-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; 50S ribosomal protein L24 complement(2639955..2640299) Arthrobacter arilaitensis Re117 9794314 YP_003917528.1 CDS rplN NC_014550.1 2640302 2640673 R part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19; 50S ribosomal protein L14 complement(2640302..2640673) Arthrobacter arilaitensis Re117 9794331 YP_003917529.1 CDS AARI_23380 NC_014550.1 2640959 2641120 D hypothetical protein 2640959..2641120 Arthrobacter arilaitensis Re117 9794321 YP_003917530.1 CDS AARI_23390 NC_014550.1 2641174 2642133 R match to PF03372: Endonuclease/Exonuclease/phosphatase family. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling. Signal peptide predicted by SignalP 3.0 HMM (probability: 0.899) with cleavage site probability 0.551 between position 43 and 44; extracellular nuclease complement(2641174..2642133) Arthrobacter arilaitensis Re117 9794903 YP_003917531.1 CDS AARI_23400 NC_014550.1 2642219 2642722 R identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein complement(2642219..2642722) Arthrobacter arilaitensis Re117 9794904 YP_003917532.1 CDS AARI_23410 NC_014550.1 2642793 2643581 D identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family; AraC family transcriptional regulator 2642793..2643581 Arthrobacter arilaitensis Re117 9794905 YP_003917533.1 CDS rpsQ NC_014550.1 2644100 2644387 R one of the primary rRNA binding proteins, it binds specifically to the 5 prime-end of 16S ribosomal RNA; 30S ribosomal protein S17 complement(2644100..2644387) Arthrobacter arilaitensis Re117 9794907 YP_003917534.1 CDS rpmC NC_014550.1 2644387 2644650 R ribosomal protein L29 is one of the proteins from the large ribosomal subunit; 50S ribosomal protein L29 complement(2644387..2644650) Arthrobacter arilaitensis Re117 9794364 YP_003917535.1 CDS rplP NC_014550.1 2644653 2645069 R part of the 50S ribosomal subunit. Cross-links to the A and P site tRNAs; 50S ribosomal protein L16 complement(2644653..2645069) Arthrobacter arilaitensis Re117 9794335 YP_003917536.1 CDS rpsC NC_014550.1 2645070 2645852 R part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14; 30S ribosomal protein S3 complement(2645070..2645852) Arthrobacter arilaitensis Re117 9794323 YP_003917537.1 CDS rplV NC_014550.1 2645853 2646218 R this protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20; 50S ribosomal protein L22 complement(2645853..2646218) Arthrobacter arilaitensis Re117 9794350 YP_003917538.1 CDS rpsS NC_014550.1 2646278 2646559 R forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(2646278..2646559) Arthrobacter arilaitensis Re117 9794329 YP_003917539.1 CDS rplB NC_014550.1 2646572 2647411 R part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome; 50S ribosomal protein L2 complement(2646572..2647411) Arthrobacter arilaitensis Re117 9794366 YP_003917540.1 CDS rplW NC_014550.1 2647443 2647745 R part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome; 50S ribosomal protein L23 complement(2647443..2647745) Arthrobacter arilaitensis Re117 9794311 YP_003917541.1 CDS rplD NC_014550.1 2647742 2648344 R one of the primary rRNA binding proteins. It is important during the early stages of 50S assembly; 50S ribosomal protein L4 complement(2647742..2648344) Arthrobacter arilaitensis Re117 9794330 YP_003917542.1 CDS rplC NC_014550.1 2648349 2648999 R part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19; 50S ribosomal protein L3 complement(2648349..2648999) Arthrobacter arilaitensis Re117 9794313 YP_003917543.1 CDS rpsJ NC_014550.1 2649020 2649328 R involved in the binding of tRNA to the ribosomes; 30S ribosomal protein S10 complement(2649020..2649328) Arthrobacter arilaitensis Re117 9794312 YP_003917544.1 CDS AARI_23540 NC_014550.1 2649735 2653502 R 37 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2649735..2653502) Arthrobacter arilaitensis Re117 9794357 YP_003917545.1 CDS tuf NC_014550.1 2653665 2654855 R responsible for the selection and binding of the cognate aminoacyl-tRNA to the A-site (acceptor site) of the ribosome; elongation factor Tu complement(2653665..2654855) Arthrobacter arilaitensis Re117 9794908 YP_003917546.1 CDS fusA NC_014550.1 2655098 2657212 R responsible for the translocation of the peptidyl- tRNA from the A-site to the P-site (peptidyl-tRNA site) of the ribosome, thereby freeing the A-site for the next aminoacyl-tRNA to bind; elongation factor G complement(2655098..2657212) Arthrobacter arilaitensis Re117 9794483 YP_003917547.1 CDS rpsG NC_014550.1 2657282 2657752 R part of the 30S ribosomal subunit. Contacts proteins S9 and S11; 30S ribosomal protein S7 complement(2657282..2657752) Arthrobacter arilaitensis Re117 9793874 YP_003917548.1 CDS rpsL NC_014550.1 2657752 2658126 R part of the 30S ribosomal subunit. Contacts proteins S8 and S17; 30S ribosomal protein S12 complement(2657752..2658126) Arthrobacter arilaitensis Re117 9794354 YP_003917549.1 CDS rpoC NC_014550.1 2658728 2662618 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; DNA-directed RNA polymerase beta prime chain complement(2658728..2662618) Arthrobacter arilaitensis Re117 9794359 YP_003917550.1 CDS rpoB NC_014550.1 2662717 2666223 R DNA-directed RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; DNA-directed RNA polymerase subunit beta complement(2662717..2666223) Arthrobacter arilaitensis Re117 9794344 YP_003917551.1 CDS AARI_23610 NC_014550.1 2666835 2667332 D match to PF04073: YbaK / prolyl-tRNA synthetases associated domain. This domain of unknown function is found in numerous prokaryote organisms. The structure of YbaK shows a novel fold. This domain also occurs in a number of prolyl-tRNA synthetases (proRS) from prokaryotes. Thus, the domain is thought to be involved in oligo-nucleotide binding, with possible roles in recognition/discrimination or editing of prolyl-tRNA; YbaK domain-containing protein 2666835..2667332 Arthrobacter arilaitensis Re117 9794343 YP_003917552.1 CDS AARI_23620 NC_014550.1 2667286 2668455 R match to protein domain PF01757. This family includes a range of acyltransferase enzymes. 10 transmembrane helices predicted by TMHMM2.0; acyltransferase domain-containing membrane protein complement(2667286..2668455) Arthrobacter arilaitensis Re117 9794909 YP_003917553.1 CDS rplL NC_014550.1 2668602 2668976 R seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation; 50S ribosomal protein L7/L12 complement(2668602..2668976) Arthrobacter arilaitensis Re117 9794910 YP_003917554.1 CDS rplJ NC_014550.1 2669050 2669571 R 50S ribosomal protein L10 complement(2669050..2669571) Arthrobacter arilaitensis Re117 9794319 YP_003917555.1 CDS rplA NC_014550.1 2670127 2670828 R part of the 50S ribosomal subunit. Binds directly to 23S rRNA. Is involved in E site tRNA release and is also a translational repressor protein: it controls the translation of the L11 operon by binding to its mRNA; 50S ribosomal protein L1 complement(2670127..2670828) Arthrobacter arilaitensis Re117 9794317 YP_003917556.1 CDS rplK NC_014550.1 2670964 2671395 R this protein binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 complement(2670964..2671395) Arthrobacter arilaitensis Re117 9794310 YP_003917557.1 CDS nusG NC_014550.1 2671525 2672352 R influences transcription termination and antitermination. Acts as a component of the transcription complex, and interacts with the termination factor rho and RNA polymerase; transcription antitermination protein NusG complement(2671525..2672352) Arthrobacter arilaitensis Re117 9794318 YP_003917558.1 CDS secE NC_014550.1 2672425 2672673 R identified by match to protein family PF00584. The translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF); preprotein translocase SecE subunit complement(2672425..2672673) Arthrobacter arilaitensis Re117 9794155 YP_003917559.1 CDS aspC NC_014550.1 2673129 2674328 D catalyses the following reaction: L-aspartate + 2- oxoglutarate <=> oxaloacetate + L-glutamate; aspartate transaminase 2673129..2674328 Arthrobacter arilaitensis Re117 9793638 YP_003917560.1 CDS AARI_23700 NC_014550.1 2674405 2675073 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(2674405..2675073) Arthrobacter arilaitensis Re117 9793697 YP_003917561.1 CDS AARI_23710 NC_014550.1 2675078 2676307 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; signal transduction histidine kinase complement(2675078..2676307) Arthrobacter arilaitensis Re117 9794911 YP_003917562.1 CDS AARI_23720 NC_014550.1 2676458 2677777 D identified by match to protein domain PF04024. This domain is found in Phage shock protein C (PspC) that is thought to be a transcriptional regulator; PspC domain-containing protein 2676458..2677777 Arthrobacter arilaitensis Re117 9794912 YP_003917563.1 CDS AARI_23730 NC_014550.1 2677790 2678038 D hypothetical protein 2677790..2678038 Arthrobacter arilaitensis Re117 9794913 YP_003917564.1 CDS AARI_23740 NC_014550.1 2678073 2678315 D identified by match to protein domain PF04024. This domain is found in Phage shock protein C (PspC) that is thought to be a transcriptional regulator; PspC domain-containing protein 2678073..2678315 Arthrobacter arilaitensis Re117 9794914 YP_003917565.1 CDS pfkA NC_014550.1 2678572 2679600 D catalyzes the phosphorylation of fructose-6- phosphate to fructose-1,6-biphosphate; 6-phosphofructokinase 2678572..2679600 Arthrobacter arilaitensis Re117 9794915 YP_003917566.1 CDS AARI_23760 NC_014550.1 2679675 2680757 R aminomethyltransferase complement(2679675..2680757) Arthrobacter arilaitensis Re117 9794196 YP_003917567.1 CDS AARI_23770 NC_014550.1 2680760 2681374 R match to PF08768: domain of unknown function (DUF1794); hypothetical protein complement(2680760..2681374) Arthrobacter arilaitensis Re117 9794916 YP_003917568.1 CDS AARI_23780 NC_014550.1 2681445 2681564 R hypothetical protein complement(2681445..2681564) Arthrobacter arilaitensis Re117 9794917 YP_003917569.1 CDS AARI_23790 NC_014550.1 2681642 2682382 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.998) with cleavage site probability 0.386 between position 19 and 20. 8 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(2681642..2682382) Arthrobacter arilaitensis Re117 9794918 YP_003917570.1 CDS AARI_23800 NC_014550.1 2682509 2683177 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 2682509..2683177 Arthrobacter arilaitensis Re117 9794919 YP_003917571.1 CDS AARI_23810 NC_014550.1 2683230 2684186 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2683230..2684186 Arthrobacter arilaitensis Re117 9794920 YP_003917572.1 CDS ppk NC_014550.1 2684269 2686485 D catalyzes the following reaction: ATP + (phosphate)(n) <=> ADP + (phosphate)(n+1). involved in phosphate metabolism of bacteria; polyphosphate kinase 2684269..2686485 Arthrobacter arilaitensis Re117 9794921 YP_003917573.1 CDS AARI_23830 NC_014550.1 2686485 2687492 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 2686485..2687492 Arthrobacter arilaitensis Re117 9794218 YP_003917574.1 CDS AARI_23840 NC_014550.1 2687632 2687964 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2687632..2687964 Arthrobacter arilaitensis Re117 9794922 YP_003917575.1 CDS thyA NC_014550.1 2688039 2688842 D catalyzes the reductive methylation of dUMP to dTMP with concomitant conversion of 5,10- methylenetetrahydrofolate to dihydrofolate; thymidylate synthase 2688039..2688842 Arthrobacter arilaitensis Re117 9794923 YP_003917576.1 CDS folA NC_014550.1 2688839 2689414 D catalyzes the NADPH-linked reduction of 7,8- dihydrofolate to 5,6,7,8-tetrahydrofolate, but also the NADPH-linked reduction of folate to 7,8-dihydrofolate; dihydrofolate reductase 2688839..2689414 Arthrobacter arilaitensis Re117 9794452 YP_003917577.1 CDS AARI_23870 NC_014550.1 2689422 2689649 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2689422..2689649 Arthrobacter arilaitensis Re117 9793856 YP_003917578.1 CDS asd NC_014550.1 2689798 2690880 D catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate- semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine; aspartate-semialdehyde dehydrogenase 2689798..2690880 Arthrobacter arilaitensis Re117 9794924 YP_003917579.1 CDS AARI_23890 NC_014550.1 2690975 2691499 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(2690975..2691499) Arthrobacter arilaitensis Re117 9793693 YP_003917580.1 CDS murB NC_014550.1 2691519 2692580 R catalyses the formation of UDP-N-acetylmuramate from UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. Involved in the biosynthesis of peptidoglycan; UDP-N-acetylmuramate dehydrogenase complement(2691519..2692580) Arthrobacter arilaitensis Re117 9794925 YP_003917581.1 CDS AARI_23910 NC_014550.1 2692634 2693833 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter complement(2692634..2693833) Arthrobacter arilaitensis Re117 9794117 YP_003917582.1 CDS AARI_23920 NC_014550.1 2693836 2694276 R match to PF01575. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl- CoA hydratase activity; MaoC like domain-containing protein complement(2693836..2694276) Arthrobacter arilaitensis Re117 9794926 YP_003917583.1 CDS AARI_23930 NC_014550.1 2694279 2694725 R match to PF01575. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl- CoA hydratase activity; MaoC like domain-containing protein complement(2694279..2694725) Arthrobacter arilaitensis Re117 9794927 YP_003917584.1 CDS AARI_23940 NC_014550.1 2694824 2695099 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2694824..2695099) Arthrobacter arilaitensis Re117 9794928 YP_003917585.1 CDS AARI_23950 NC_014550.1 2695199 2696140 R hypothetical protein complement(2695199..2696140) Arthrobacter arilaitensis Re117 9794929 YP_003917586.1 CDS AARI_23960 NC_014550.1 2696335 2697153 D match to PF04607. This region of unknown function is found in RelA and SpoT of Escherichia coli, and their homologues in plants and in other eubacteria; RelA/SpoT domain-containing protein 2696335..2697153 Arthrobacter arilaitensis Re117 9794930 YP_003917587.1 CDS AARI_23970 NC_014550.1 2697418 2697675 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.976) with cleavage site probability 0.739 between position 24 and 25; hypothetical protein 2697418..2697675 Arthrobacter arilaitensis Re117 9794931 YP_003917588.1 CDS thiC NC_014550.1 2698928 2700670 D required for the synthesis of the hydromethylpyrimidine (HMP) moiety of thiamine (4-amino-2- methyl-5-hydroxymethylpyrimidine); thiamine biosynthesis protein ThiC 2698928..2700670 Arthrobacter arilaitensis Re117 9793641 YP_003917589.1 CDS AARI_23990 NC_014550.1 2700764 2702692 R DEAD box helicase. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression; ATP-dependent RNA helicase complement(2700764..2702692) Arthrobacter arilaitensis Re117 9794439 YP_003917590.1 CDS AARI_24000 NC_014550.1 2702989 2703405 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2702989..2703405 Arthrobacter arilaitensis Re117 9794933 YP_003917591.1 CDS metB NC_014550.1 2703504 2704661 R catalyzes the conversion of cysteine and succinyl- homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms; cystathionine gamma-synthase complement(2703504..2704661) Arthrobacter arilaitensis Re117 9794934 YP_003917592.1 CDS AARI_24020 NC_014550.1 2704689 2706053 R catalyses the synthesis of L-cystathionine from L- serine and L-homocysteine; cystathionine beta-synthase complement(2704689..2706053) Arthrobacter arilaitensis Re117 9794069 YP_003917593.1 CDS AARI_24030 NC_014550.1 2706193 2707155 D hypothetical protein 2706193..2707155 Arthrobacter arilaitensis Re117 9794935 YP_003917594.1 CDS trx NC_014550.1 2707180 2707554 R serves as a general protein disulphide oxidoreductase. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of 2 cysteine thiol groups to a disulphide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulphide and a dithiol; thioredoxin complement(2707180..2707554) Arthrobacter arilaitensis Re117 9794936 YP_003917595.1 CDS AARI_35600 NC_014550.1 2707918 2709225 R transposase of ISAar20, ISL3 family complement(2707918..2709225) Arthrobacter arilaitensis Re117 9793642 YP_003917596.1 CDS AARI_24050 NC_014550.1 2709417 2709905 D match to protein family PF04461: protein of unknown function (DUF520); hypothetical protein 2709417..2709905 Arthrobacter arilaitensis Re117 9793501 YP_003917597.1 CDS AARI_24060 NC_014550.1 2710011 2710607 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2710011..2710607) Arthrobacter arilaitensis Re117 9794937 YP_003917598.1 CDS htpX NC_014550.1 2710833 2711705 R in Escherichia coli, HtpX is a membrane- bound zinc metalloprotease that has been suggested to participate in the proteolytic quality control of membrane proteins in conjunction with FtsH, a membrane-bound and ATP-dependent protease. 6 transmembrane helices predicted by TMHMM2.0. Match to protein family PF01435; protease HtpX-like protein complement(2710833..2711705) Arthrobacter arilaitensis Re117 9794938 YP_003917599.1 CDS rarD NC_014550.1 2711945 2712883 D drug/metabolite transporter (DMT) superfamily, chloramphenicol-sensitivity protein (RarD) family (TC 2.A. 7.7.z). No member of the RarD family is functionally characterized. Identified by match to TIGR00688; RarD protein 2711945..2712883 Arthrobacter arilaitensis Re117 9793987 YP_003917600.1 CDS gabT NC_014550.1 2712981 2714324 R catalyzes the transfer of an amino group from GABA to alpha-ketoglutarate, yielding succinate semialdehyde and glutamic acid; 4-aminobutyrate transaminase complement(2712981..2714324) Arthrobacter arilaitensis Re117 9794282 YP_003917601.1 CDS AARI_24100 NC_014550.1 2714529 2714672 R hypothetical protein complement(2714529..2714672) Arthrobacter arilaitensis Re117 9793878 YP_003917602.1 CDS AARI_24110 NC_014550.1 2714675 2716282 R Neurotransmitter:Sodium Symporter (NSS) Family (Tc 2.A.22.y.z). Members of the NSS family catalyze uptake of a variety of neurotransmitters, amino acids, osmolytes and related nitrogenous substances by a solute:Na+ symport mechanism. Sometimes Cl- is cotransported, and some exhibit a K+ dependency. Might be involved in the transport of gamma-aminobutyric acid; sodium-dependent transporter complement(2714675..2716282) Arthrobacter arilaitensis Re117 9794939 YP_003917603.1 CDS AARI_24120 NC_014550.1 2716396 2717799 D match to PF07905: purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR, O32138). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being regulatory proteins; transcriptional regulator 2716396..2717799 Arthrobacter arilaitensis Re117 9794940 YP_003917604.1 CDS AARI_24130 NC_014550.1 2717818 2718252 D hypothetical protein 2717818..2718252 Arthrobacter arilaitensis Re117 9794941 YP_003917605.1 CDS AARI_24140 NC_014550.1 2718252 2718764 D match to protein family IPR001310: histidine triad (HIT) protein. The histidine triad motif (HIT) is related to the sequence H-phi-H-phi-H-phi-phi (where phi is a hydrophobic amino acid). Proteins containing HIT domains form a superfamily of nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides; histidine triad family protein 2718252..2718764 Arthrobacter arilaitensis Re117 9794942 YP_003917606.1 CDS AARI_24150 NC_014550.1 2718840 2719937 R produces prenyl diphosphates which act as the priming substrates for other groups of prenyl transferases. Is implicated in the biosynthesis of ubiquinone; trans-hexaprenyltranstransferase complement(2718840..2719937) Arthrobacter arilaitensis Re117 9794943 YP_003917607.1 CDS menF NC_014550.1 2720229 2721566 D catalyses the conversion of chorismate to isochorismate, the first step in the biosynthesis of both the respiratory chain component menaquinone (MK, vitamin K2) and phylloquinone (vitamin K1): Chorismate <=> isochorismate; isochorismate synthase 2720229..2721566 Arthrobacter arilaitensis Re117 9794944 YP_003917608.1 CDS AARI_24170 NC_014550.1 2721740 2722528 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family (TC 3.A.1.3.z). ABCISSE: ABC transporter, binding protein (BP), PAO-family (polar amino acid and opines). The PAO family includes transport systems for amino acids that have polar or charged side chains: lysine, histidine, ornithine, arginine, glutamine, glutamate, cystine and diaminopimelic acid; polar amino acid ABC transporter substrate-binding protein 2721740..2722528 Arthrobacter arilaitensis Re117 9794066 YP_003917609.1 CDS AARI_24180 NC_014550.1 2722640 2723431 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family (TC 3.A.1.3.z). ABCISSE: ABC transporter, permease (IM), PAO- family (polar amino acid and opines). The PAO family includes transport systems for amino acids that have polar or charged side chains: lysine, histidine, ornithine, arginine, glutamine, glutamate, cystine and diaminopimelic acid; polar amino acid ABC transporter inner membrane subunit 2722640..2723431 Arthrobacter arilaitensis Re117 9794945 YP_003917610.1 CDS AARI_24190 NC_014550.1 2723446 2724228 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family (TC 3.A.1.3.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), PAO-family (polar amino acid and opines). The PAO family includes transport systems for amino acids that have polar or charged side chains: lysine, histidine, ornithine, arginine, glutamine, glutamate, cystine and diaminopimelic acid; polar amino acid ABC transporter ATP-binding subunit 2723446..2724228 Arthrobacter arilaitensis Re117 9794946 YP_003917611.1 CDS menD NC_014550.1 2724300 2725997 R EC 2.2.1.9 plays a key role in the menaquinone biosynthetic pathway, converting isochorismate and 2- oxoglutarate to SHCHC (2-succinyl-6-hydroxyl-2,4- cyclohexadiene-1-carboxylic acid), pyruvate and carbon dioxide; bifunctional 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase complement(2724300..2725997) Arthrobacter arilaitensis Re117 9794947 YP_003917612.1 CDS AARI_24210 NC_014550.1 2726148 2728271 R match to PS00583 pattern: PTS HPR domain serine phosphorylation site; hypothetical protein complement(2726148..2728271) Arthrobacter arilaitensis Re117 9794064 YP_003917613.1 CDS menC NC_014550.1 2728397 2729392 R catalyzes the conversion of 2-succinyl-6-hydroxy- 2, 4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2- carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; O-succinylbenzoate synthase complement(2728397..2729392) Arthrobacter arilaitensis Re117 9794948 YP_003917614.1 CDS AARI_24230 NC_014550.1 2729473 2730336 D PAP2 family protein 2729473..2730336 Arthrobacter arilaitensis Re117 9794063 YP_003917615.1 CDS AARI_24240 NC_014550.1 2730364 2731395 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2730364..2731395) Arthrobacter arilaitensis Re117 9794949 YP_003917616.1 CDS AARI_24250 NC_014550.1 2731631 2733040 R possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes; 2-oxoacid dehydrogenase E2 component complement(2731631..2733040) Arthrobacter arilaitensis Re117 9794950 YP_003917617.1 CDS AARI_24260 NC_014550.1 2733041 2734123 R possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes; 2-oxoacid dehydrogenase E1 component subunit beta complement(2733041..2734123) Arthrobacter arilaitensis Re117 9794951 YP_003917618.1 CDS AARI_24270 NC_014550.1 2734125 2735288 R possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes; 2-oxoacid dehydrogenase E1 component subunit alpha complement(2734125..2735288) Arthrobacter arilaitensis Re117 9794952 YP_003917619.1 CDS AARI_24280 NC_014550.1 2735515 2735967 D identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator 2735515..2735967 Arthrobacter arilaitensis Re117 9794953 YP_003917620.1 CDS paaB NC_014550.1 2736043 2736828 R involved in aromatic ring opening step of the phenylacetic acid catabolic pathway; phenylacetic acid degradation protein PaaB complement(2736043..2736828) Arthrobacter arilaitensis Re117 9794954 YP_003917621.1 CDS paaK NC_014550.1 2736847 2738007 R phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA as the second catabolic step in phenylacetic acid degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA; phenylacetate-CoA oxygenase subunit PaaK complement(2736847..2738007) Arthrobacter arilaitensis Re117 9794163 YP_003917622.1 CDS paaJ NC_014550.1 2738004 2738501 R phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA as the second catabolic step in phenylacetic acid degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA; phenylacetate-CoA oxygenase subunit PaaJ complement(2738004..2738501) Arthrobacter arilaitensis Re117 9794170 YP_003917623.1 CDS paaI NC_014550.1 2738537 2739397 R phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA as the second catabolic step in phenylacetic acid degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA; phenylacetate-CoA oxygenase subunit PaaI complement(2738537..2739397) Arthrobacter arilaitensis Re117 9794169 YP_003917624.1 CDS paaH NC_014550.1 2739394 2739684 R phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA as the second catabolic step in phenylacetic acid degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA; phenylacetate-CoA oxygenase subunit PaaH complement(2739394..2739684) Arthrobacter arilaitensis Re117 9794168 YP_003917625.1 CDS paaG NC_014550.1 2739686 2740672 R phenylacetate-CoA oxygenase is comprised of a five gene complex responsible for the hydroxylation of phenylacetate-CoA as the second catabolic step in phenylacetic acid degradation. Although the exact function of this enzyme has not been determined, it has been shown to be required for phenylacetic acid degradation and has been proposed to function in a multicomponent oxygenase acting on phenylacetate-CoA; phenylacetate-CoA oxygenase subunit PaaG complement(2739686..2740672) Arthrobacter arilaitensis Re117 9794167 YP_003917626.1 CDS AARI_24350 NC_014550.1 2740816 2741265 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2740816..2741265) Arthrobacter arilaitensis Re117 9794166 YP_003917627.1 CDS AARI_24360 NC_014550.1 2741466 2742221 R TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family (TC 3.A.1.3.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), PAO-family (polar amino acid and opines). The PAO family includes transport systems for amino acids that have polar or charged side chains: lysine, histidine, ornithine, arginine, glutamine, glutamate, cystine and diaminopimelic acid; polar amino acid ABC transporter ATP-binding subunit complement(2741466..2742221) Arthrobacter arilaitensis Re117 9794955 YP_003917628.1 CDS AARI_24370 NC_014550.1 2742218 2743687 R TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family (TC 3.A.1.3.z). ABCISSE: ABC transporter, permease and binding protein (BP-IM), PAO-family (polar amino acid and opines). The PAO family includes transport systems for amino acids that have polar or charged side chains: lysine, histidine, ornithine, arginine, glutamine, glutamate, cystine and diaminopimelic acid; polar amino acid ABC transporter inner membrane and binding protein subunit complement(2742218..2743687) Arthrobacter arilaitensis Re117 9794956 YP_003917629.1 CDS ptrB NC_014550.1 2743891 2746044 D oligopeptidase B cleaves peptide bonds on the C- terminal side of lysyl and argininyl residues. Prolyl oligopeptidase family protein (match to PF00326 and PF02897); oligopeptidase B 2743891..2746044 Arthrobacter arilaitensis Re117 9794957 YP_003917630.1 CDS AARI_24390 NC_014550.1 2746066 2747079 D match to PF00583: acetyltransferase (GNAT) family. Match to PF042229: Uncharacterised protein family (UPF0157); GNAT family acetyltransferase 2746066..2747079 Arthrobacter arilaitensis Re117 9794241 YP_003917631.1 CDS paaD NC_014550.1 2747174 2747620 D PaaD protein is nearly always found adjacent to other genes of the phenylacetic acid degradation pathway. Its function is currently unknown, but a role as thioesterases is suggested; phenylacetic acid degradation protein PaaD 2747174..2747620 Arthrobacter arilaitensis Re117 9794958 YP_003917632.1 CDS paaF NC_014550.1 2747653 2748972 D catalyses the formation of phenylacetyl-CoA from phenylacetate. Involved in the catabolism of phenylacetic acid; phenylacetate--CoA ligase 2747653..2748972 Arthrobacter arilaitensis Re117 9794164 YP_003917633.1 CDS AARI_24420 NC_014550.1 2749004 2749621 D identified by match to PF00440: bacterial regulatory proteins, tetR family; TetR family transcriptional regulator 2749004..2749621 Arthrobacter arilaitensis Re117 9794165 YP_003917634.1 CDS AARI_24430 NC_014550.1 2749773 2750552 D 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2749773..2750552 Arthrobacter arilaitensis Re117 9794959 YP_003917635.1 CDS AARI_24440 NC_014550.1 2750610 2752319 R enzymes of this family comprise mostly alpha- amylases (EC 3.2.1.1); pullulanases (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); glycosyl hydrolase family 13 protein complement(2750610..2752319) Arthrobacter arilaitensis Re117 9794960 YP_003917636.1 CDS paaN NC_014550.1 2752713 2754836 R involved in aromatic ring opening step of the phenylacetic acid catabolic pathway; phenylacetic acid degradation protein PaaN complement(2752713..2754836) Arthrobacter arilaitensis Re117 9794961 YP_003917637.1 CDS AARI_24460 NC_014550.1 2754952 2755674 R match to PS00383 pattern (tyrosine specific protein phosphatases active site) and PS50056 (tyrosine specific protein phosphatases family profile); hypothetical protein complement(2754952..2755674) Arthrobacter arilaitensis Re117 9794171 YP_003917638.1 CDS AARI_24470 NC_014550.1 2755815 2756717 D identified by match to protein family PF01163. Protein kinases are a group of enzymes that possess a catalytic subunit which transfers the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. They play a role in a mulititude of cellular processes, including division, proliferation, apoptosis, and differentiation; RIO-type Ser/Thr protein kinase 2755815..2756717 Arthrobacter arilaitensis Re117 9794962 YP_003917639.1 CDS AARI_24480 NC_014550.1 2756798 2757670 R 3-hydroxyacyl-CoA dehydrogenase is an enzyme involved in fatty acid metabolism. It catalyzes the reduction of 3-hydroxyacyl-CoA to 3-oxoacyl-CoA; 3-hydroxyacyl-CoA dehydrogenase complement(2756798..2757670) Arthrobacter arilaitensis Re117 9794963 YP_003917640.1 CDS AARI_24490 NC_014550.1 2757673 2758467 R enoyl-CoA hydratase is involved in fatty acid metabolism. It catalyzes the hydratation of 2-trans-enoyl- CoA into 3-hydroxyacyl-CoA; enoyl-CoA hydratase complement(2757673..2758467) Arthrobacter arilaitensis Re117 9794964 YP_003917641.1 CDS AARI_24500 NC_014550.1 2758469 2759692 R acetyl-CoA C-acyltransferase (also named 3-ketoacyl- CoA thiolase or thiolase I) has a broad chain-length specificity for its substrates and is involved in degradative pathways such as fatty acid beta-oxidation; acetyl-CoA C-acyltransferase complement(2758469..2759692) Arthrobacter arilaitensis Re117 9794965 YP_003917642.1 CDS proP NC_014550.1 2760029 2761456 D identified by similarity to protein SP:P0C0L7 (Escherichia coli). Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. Metabolite:H+ symporter (MHS) family, (Poline/glycine-betaine):(H+/Na+) symporter (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1- carboxymethyl-pyridinium) (subject to osmotic activation) (TC 2.A.1.6.4); proline/betaine transporter 2760029..2761456 Arthrobacter arilaitensis Re117 9794966 YP_003917643.1 CDS ansP NC_014550.1 2761539 2762978 R amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family, asparagine permease (AnsP) (TC 2.A.3.1.8); L-asparagine permease complement(2761539..2762978) Arthrobacter arilaitensis Re117 9794227 YP_003917644.1 CDS menB NC_014550.1 2763164 2764126 D converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoic acid (DHNA): o-succinylbenzoyl-CoA <=> CoA + 1,4-dihydroxy-2-naphthoate; naphthoate synthase 2763164..2764126 Arthrobacter arilaitensis Re117 9793667 YP_003917645.1 CDS menE NC_014550.1 2764155 2765282 D converts 2-succinylbenzoate (OSB) to 2- succinylbenzoyl-CoA (OSB-CoA) : ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA; O-succinylbenzoate-CoA ligase 2764155..2765282 Arthrobacter arilaitensis Re117 9794062 YP_003917646.1 CDS menA NC_014550.1 2765359 2766243 D converts 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK); 1,4-dihydroxy-2-naphthoate octaprenyltransferase 2765359..2766243 Arthrobacter arilaitensis Re117 9794065 YP_003917647.1 CDS AARI_24560 NC_014550.1 2766379 2766669 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2766379..2766669) Arthrobacter arilaitensis Re117 9794061 YP_003917648.1 CDS AARI_24570 NC_014550.1 2766723 2767172 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.947) with cleavage site probability 0.685 between position 26 and 27; hypothetical protein 2766723..2767172 Arthrobacter arilaitensis Re117 9794967 YP_003917649.1 CDS AARI_24580 NC_014550.1 2767368 2768435 R identified by match to protein family PF01578; cytochrome C assembly protein complement(2767368..2768435) Arthrobacter arilaitensis Re117 9794968 YP_003917650.1 CDS AARI_24590 NC_014550.1 2768428 2770056 R identified by match to protein family PF05140; cytochrome C biosynthesis protein complement(2768428..2770056) Arthrobacter arilaitensis Re117 9794969 YP_003917651.1 CDS AARI_24600 NC_014550.1 2770056 2770811 R identified by match to PF02683: Cytochrome C biogenesis protein transmembrane region; cytochrome C biosynthesis protein complement(2770056..2770811) Arthrobacter arilaitensis Re117 9794970 YP_003917652.1 CDS AARI_24610 NC_014550.1 2770820 2771443 R identified by match to protein family PF08534. This family of redoxins includes peroxiredoxin, thioredoxin and glutaredoxin proteins; redoxin domain-containing protein complement(2770820..2771443) Arthrobacter arilaitensis Re117 9794971 YP_003917653.1 CDS AARI_24620 NC_014550.1 2771450 2772112 R identified by match to protein domain PF00300; phosphoglycerate mutase family protein complement(2771450..2772112) Arthrobacter arilaitensis Re117 9794972 YP_003917654.1 CDS AARI_24630 NC_014550.1 2772286 2773041 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2772286..2773041 Arthrobacter arilaitensis Re117 9794973 YP_003917655.1 CDS rex NC_014550.1 2773158 2773793 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(2773158..2773793) Arthrobacter arilaitensis Re117 9794974 YP_003917656.1 CDS AARI_24650 NC_014550.1 2773860 2774096 R identified by match to PF05768: glutaredoxin-like domain (DUF836). This family contains several viral glutaredoxins, and many related bacterial and eukaryotic proteins of unknown function. Glutaredoxins are small proteins of approximately one hundred amino-acid residues which utilise glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase; glutaredoxin complement(2773860..2774096) Arthrobacter arilaitensis Re117 9794293 YP_003917657.1 CDS AARI_24660 NC_014550.1 2774168 2774974 D identified by match to PF00702. This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases; haloacid dehalogenase 2774168..2774974 Arthrobacter arilaitensis Re117 9794975 YP_003917658.1 CDS AARI_24670 NC_014550.1 2775315 2775539 R hypothetical protein complement(2775315..2775539) Arthrobacter arilaitensis Re117 9794976 YP_003917659.1 CDS gdhA NC_014550.1 2775799 2777142 R catalyses the conversion of 2-oxoglutarate to glutamate; NADP-specific glutamate dehydrogenase complement(2775799..2777142) Arthrobacter arilaitensis Re117 9794977 YP_003917660.1 CDS AARI_24690 NC_014550.1 2777333 2777770 R identified by match to PF01022: bacterial regulatory protein, ArsR family. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator complement(2777333..2777770) Arthrobacter arilaitensis Re117 9793896 YP_003917661.1 CDS acuC NC_014550.1 2777872 2779074 R AcuC may be involved in growth of some bacteria on butanediol and acetoin; acetoin utilization protein AcuC complement(2777872..2779074) Arthrobacter arilaitensis Re117 9794978 YP_003917662.1 CDS trkH NC_014550.1 2779248 2780681 D K+ transporter (Trk) family (TC 2.A.38.y.z). Membrane component of a Trk-type K+ transport system. Match to protein family PF02386; Trk system potassium uptake protein TrkH 2779248..2780681 Arthrobacter arilaitensis Re117 9793656 YP_003917663.1 CDS trkA NC_014550.1 2780674 2781345 D voltage-gated K+ Channel beta-subunit family, TrkA regulatory subunit of TrkH and TrkG (TC 8.A.5.2.1). Part of a potassium transport system (regulatory subunit). TrkA domains can bind NAD+ and NADH, possibly allowing K+ transporters to be responsive to the redox state of the cell. Systems regulated by TrkA include TrkG/H (TC 2.A.38. 1.1); Trk system potassium uptake protein TrkA 2780674..2781345 Arthrobacter arilaitensis Re117 9794463 YP_003917664.1 CDS proC NC_014550.1 2781422 2782264 R catalyses the terminal step in the biosynthesis of proline from glutamate, the NAD(P) dependent oxidation of 1-pyrroline-5-carboxylate into proline; pyrroline-5-carboxylate reductase complement(2781422..2782264) Arthrobacter arilaitensis Re117 9794462 YP_003917665.1 CDS AARI_24740 NC_014550.1 2782269 2783093 R match to protein domain PF01261: xylose isomerase- like TIM barrel . This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC.1.21. 2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins; xylose isomerase-like protein complement(2782269..2783093) Arthrobacter arilaitensis Re117 9794225 YP_003917666.1 CDS AARI_24750 NC_014550.1 2783148 2784167 R identified by match to protein family PF02541. Similar to exopolyphosphatase (Ppx, EC 3.6.1.11) and guanosine pentaphosphate phospho-hydrolase (GppA, EC 3.6.1. 40) proteins; Ppx/GppA phosphatase family protein complement(2783148..2784167) Arthrobacter arilaitensis Re117 9794979 YP_003917667.1 CDS topA NC_014550.1 2784200 2786989 R catalytic activity: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining; DNA topoisomerase I complement(2784200..2786989) Arthrobacter arilaitensis Re117 9794980 YP_003917668.1 CDS AARI_24770 NC_014550.1 2787139 2787789 R identified by match to PF01022. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator complement(2787139..2787789) Arthrobacter arilaitensis Re117 9794457 YP_003917669.1 CDS AARI_24780 NC_014550.1 2787813 2789402 R match to protein domain PF05175. This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases; methyltransferase complement(2787813..2789402) Arthrobacter arilaitensis Re117 9794981 YP_003917670.1 CDS AARI_24790 NC_014550.1 2789475 2790053 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2789475..2790053 Arthrobacter arilaitensis Re117 9794982 YP_003917671.1 CDS AARI_24800 NC_014550.1 2790107 2791006 R predicted sulfurtransferase; hypothetical protein complement(2790107..2791006) Arthrobacter arilaitensis Re117 9794983 YP_003917672.1 CDS AARI_24810 NC_014550.1 2791172 2791828 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2791172..2791828 Arthrobacter arilaitensis Re117 9794984 YP_003917673.1 CDS AARI_24820 NC_014550.1 2791930 2794260 D possible DNA or RNA helicase; ATP-dependent helicase 2791930..2794260 Arthrobacter arilaitensis Re117 9794985 YP_003917674.1 CDS AARI_24830 NC_014550.1 2794276 2794671 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.710 between position 48 and 49; hypothetical protein complement(2794276..2794671) Arthrobacter arilaitensis Re117 9794986 YP_003917675.1 CDS AARI_24840 NC_014550.1 2794668 2795003 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(2794668..2795003) Arthrobacter arilaitensis Re117 9794987 YP_003917676.1 CDS AARI_24850 NC_014550.1 2795007 2795189 R hypothetical protein complement(2795007..2795189) Arthrobacter arilaitensis Re117 9794988 YP_003917677.1 CDS AARI_24890 NC_014550.1 2798463 2798573 D hypothetical protein 2798463..2798573 Arthrobacter arilaitensis Re117 9794992 YP_003917678.1 CDS AARI_24900 NC_014550.1 2798649 2798924 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2798649..2798924) Arthrobacter arilaitensis Re117 9794993 YP_003917679.1 CDS AARI_24910 NC_014550.1 2798958 2799518 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.984 between position 32 and 33; hypothetical protein complement(2798958..2799518) Arthrobacter arilaitensis Re117 9794994 YP_003917680.1 CDS AARI_24920 NC_014550.1 2799856 2800365 D hypothetical protein 2799856..2800365 Arthrobacter arilaitensis Re117 9794995 YP_003917681.1 CDS AARI_24930 NC_014550.1 2800383 2800616 R hypothetical protein complement(2800383..2800616) Arthrobacter arilaitensis Re117 9794996 YP_003917682.1 CDS AARI_24940 NC_014550.1 2800742 2801278 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.691) with cleavage site probability 0.462 between position 29 and 30. 1 transmembrane helice predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(2800742..2801278) Arthrobacter arilaitensis Re117 9794997 YP_003917683.1 CDS AARI_24950 NC_014550.1 2801275 2801949 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.998) with cleavage site probability 0.533 between position 21 and 22. 2 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(2801275..2801949) Arthrobacter arilaitensis Re117 9794998 YP_003917684.1 CDS AARI_24960 NC_014550.1 2801953 2803194 R identified by match to protein domain PF00437; type II/IV secretion system protein E complement(2801953..2803194) Arthrobacter arilaitensis Re117 9794999 YP_003917685.1 CDS AARI_24970 NC_014550.1 2803194 2804258 R hypothetical protein complement(2803194..2804258) Arthrobacter arilaitensis Re117 9795000 YP_003917686.1 CDS AARI_24980 NC_014550.1 2804403 2806052 D DNA polymerase I 2804403..2806052 Arthrobacter arilaitensis Re117 9795001 YP_003917687.1 CDS AARI_24990 NC_014550.1 2806059 2806736 R identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase complement(2806059..2806736) Arthrobacter arilaitensis Re117 9795002 YP_003917688.1 CDS nth NC_014550.1 2806733 2807527 R also named endonuclease III. It is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidized pyrimidines from DNA, and as an apurinic/apyrimidinic endonuclease, introducing a single- strand nick at the site from which the damaged base was removed; DNA-(apurinic or apyrimidinic site) lyase complement(2806733..2807527) Arthrobacter arilaitensis Re117 9795003 YP_003917689.1 CDS acsA NC_014550.1 2807712 2809709 D catalyzes the formation of acetyl-CoA from acetate and CoA; acetate--CoA ligase 2807712..2809709 Arthrobacter arilaitensis Re117 9794151 YP_003917690.1 CDS aroQ NC_014550.1 2809842 2810294 D third enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone; 3-dehydroquinate dehydratase 2809842..2810294 Arthrobacter arilaitensis Re117 9793655 YP_003917691.1 CDS AARI_25030 NC_014550.1 2810305 2811498 R match to PF00089. This group of serine proteases belong to the MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)) and to peptidase family S6 (Hap serine peptidases). 4 transmembrane helices predicted by TMHMM2.0; membrane-associated serine protease complement(2810305..2811498) Arthrobacter arilaitensis Re117 9793689 YP_003917692.1 CDS AARI_25040 NC_014550.1 2811700 2812377 D cd00038: effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription; Crp/Fnr family transcriptional regulator 2811700..2812377 Arthrobacter arilaitensis Re117 9795004 YP_003917693.1 CDS AARI_25050 NC_014550.1 2812457 2813371 R identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase complement(2812457..2813371) Arthrobacter arilaitensis Re117 9795005 YP_003917694.1 CDS AARI_25060 NC_014550.1 2813433 2813909 R identified by match to protein domain PF01042: endoribonuclease L-PSP; endoribonuclease active on single- stranded mRNA. Inhibits protein synthesis by cleavage of mRNA. Previously thought to inhibit protein synthesis initiation. This protein may also be involved in the regulation of purine biosynthesis; endoribonuclease complement(2813433..2813909) Arthrobacter arilaitensis Re117 9795006 YP_003917695.1 CDS AARI_25070 NC_014550.1 2813942 2814097 R hypothetical protein complement(2813942..2814097) Arthrobacter arilaitensis Re117 9795007 YP_003917696.1 CDS AARI_25080 NC_014550.1 2814135 2816417 D match to PF00912 and PF00905. Transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyses the polymerisation of murein glycan chains. Possibly involved in peptidoglycan biosynthesis; penicillin-binding protein 2814135..2816417 Arthrobacter arilaitensis Re117 9795008 YP_003917697.1 CDS AARI_25090 NC_014550.1 2816538 2817491 D match to protein domain PF00149. The metallophosphoesterase motif is found in a large number of proteins invoved in phosphoryation. These include Ser/Thr phosphatases, DNA polymerase, exonucleases, and other phosphatases; metallophosphoesterase domain-containing protein 2816538..2817491 Arthrobacter arilaitensis Re117 9795009 YP_003917698.1 CDS AARI_25100 NC_014550.1 2817664 2819487 D TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, LLP- subfamily (LIP-like exporters). The function of LIP-like exporters is presently unknown; ABC transporter ATPase and permease components 2817664..2819487 Arthrobacter arilaitensis Re117 9795010 YP_003917699.1 CDS AARI_25110 NC_014550.1 2819484 2821292 D TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, LLP- subfamily (LIP-like exporters). The function of LIP-like exporters is presently unknown; ABC transporter ATPase and permease components 2819484..2821292 Arthrobacter arilaitensis Re117 9795011 YP_003917700.1 CDS purC NC_014550.1 2821376 2822281 R catalyzes the seventh step of the de novo biosynthesis of purine nucleotides, the conversion of carboximideaminoimidazole ribonucleotide (CAIR) into succinoaminoimidazolecarboximide ribonucleotide (SAICAR); phosphoribosylaminoimidazolesuccinocarboxamide synthase complement(2821376..2822281) Arthrobacter arilaitensis Re117 9795012 YP_003917701.1 CDS purD NC_014550.1 2822297 2823583 R catalyzes the second step in the de novo biosynthesis of purine, the ATP-dependent addition of 5- phosphoribosylamine to glycine to form 5- phosphoribosylglycinamide; phosphoribosylamine--glycine ligase complement(2822297..2823583) Arthrobacter arilaitensis Re117 9794246 YP_003917702.1 CDS AARI_25140 NC_014550.1 2823885 2824265 D hypothetical protein 2823885..2824265 Arthrobacter arilaitensis Re117 9794247 YP_003917703.1 CDS AARI_25150 NC_014550.1 2824270 2824596 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2824270..2824596 Arthrobacter arilaitensis Re117 9795013 YP_003917704.1 CDS purF NC_014550.1 2824702 2826225 D catalyzes the first step in purine biosynthesis, the transfer of the ammonia group of glutamine to PRPP to form 5-phosphoribosylamine; amidophosphoribosyltransferase 2824702..2826225 Arthrobacter arilaitensis Re117 9795014 YP_003917705.1 CDS purM NC_014550.1 2826233 2827447 D catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; phosphoribosylformylglycinamidine cyclo-ligase 2826233..2827447 Arthrobacter arilaitensis Re117 9794249 YP_003917706.1 CDS npdA NC_014550.1 2827560 2828450 R identified by match to PF02146: Sir2 family. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. Function: modulate the activities of several enzymes which are inactive in their acetylated form. Catalytic activity: NAD+ + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein; NAD-dependent deacetylase complement(2827560..2828450) Arthrobacter arilaitensis Re117 9794253 YP_003917707.1 CDS AARI_25190 NC_014550.1 2828641 2828859 R hypothetical protein complement(2828641..2828859) Arthrobacter arilaitensis Re117 9794143 YP_003917708.1 CDS AARI_25200 NC_014550.1 2829083 2829736 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 2829083..2829736 Arthrobacter arilaitensis Re117 9795015 YP_003917709.1 CDS clpB NC_014550.1 2829812 2832400 R part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with dnaK, dnaJ and grpE. Acts before dnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of clpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by dnaK; chaperone protein ClpB complement(2829812..2832400) Arthrobacter arilaitensis Re117 9795016 YP_003917710.1 CDS AARI_25220 NC_014550.1 2832572 2833078 D hypothetical protein 2832572..2833078 Arthrobacter arilaitensis Re117 9793737 YP_003917711.1 CDS AARI_25230 NC_014550.1 2833098 2833565 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2833098..2833565 Arthrobacter arilaitensis Re117 9795017 YP_003917712.1 CDS AARI_25240 NC_014550.1 2833835 2835019 D identified by match to protein family PF03741. This family contains a number of integral membrane proteins that also contains the TerC protein. TerC has been implicated in resistance to tellurium. This protein may be involved in efflux of tellurium ions; TerC family membrane protein 2833835..2835019 Arthrobacter arilaitensis Re117 9795018 YP_003917713.1 CDS AARI_25260 NC_014550.1 2835696 2836181 R hypothetical protein complement(2835696..2836181) Arthrobacter arilaitensis Re117 9795020 YP_003917714.1 CDS AARI_25270 NC_014550.1 2836268 2836678 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2836268..2836678) Arthrobacter arilaitensis Re117 9795021 YP_003917715.1 CDS trmB NC_014550.1 2836806 2837663 D catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; tRNA (guanine-N(7)-)-methyltransferase 2836806..2837663 Arthrobacter arilaitensis Re117 9795022 YP_003917716.1 CDS AARI_25290 NC_014550.1 2837714 2838340 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 2837714..2838340 Arthrobacter arilaitensis Re117 9794464 YP_003917717.1 CDS hspR NC_014550.1 2838337 2838765 R heat shock protein regulators (HspR) have been shown to regulate expression of specific regulons in response to high temperature or high osmolarity in Streptomyces and Helicobacter, respectively. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements; heat shock protein regulator HspR complement(2838337..2838765) Arthrobacter arilaitensis Re117 9795023 YP_003917718.1 CDS AARI_25310 NC_014550.1 2838879 2839853 R match to protein domain PF00226. DnaJ domains (J- domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system; DnaJ domain chaperone protein complement(2838879..2839853) Arthrobacter arilaitensis Re117 9793986 YP_003917719.1 CDS grpE NC_014550.1 2839938 2840519 R identified by match to protein family PF01025. Molecular chaperones are a diverse family of proteins that function to protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. The bacterial molecular chaperone DnaK (Hsp70) is an enzyme that couples cycles of ATP binding, hydrolysis, and ADP release by an N-terminal ATP-hydrolysing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. In prokaryotes the grpE protein is the co- chaperone for DnaK, and acts as a nucleotide exchange factor, stimulating the rate of ADP release 5000-fold. DnaK is itself a weak ATPase; ATP hydrolysis by DnaK is stimulated by its interaction with another co-chaperone, DnaJ. Thus the co-chaperones DnaJ and GrpE are capable of tightly regulating the nucleotide-bound and substrate- bound state of DnaK in ways that are necessary for the normal housekeeping functions and stress-related functions of the DnaK molecular chaperone cycle; GrpE protein complement(2839938..2840519) Arthrobacter arilaitensis Re117 9795024 YP_003917720.1 CDS dnaK NC_014550.1 2840534 2842387 R identified by match to protein family TIGR02350. Molecular chaperones are a diverse family of proteins that function to protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. The bacterial molecular chaperone DnaK (Hsp70) is an enzyme that couples cycles of ATP binding, hydrolysis, and ADP release by an N-terminal ATP-hydrolysing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. In prokaryotes, the grpE protein is a co- chaperone for DnaK, and acts as a nucleotide exchange factor, stimulating the rate of ADP release 5000-fold. DnaK is itself a weak ATPase; ATP hydrolysis by DnaK is stimulated by its interaction with another co-chaperone, DnaJ. Thus the co-chaperones DnaJ and GrpE are capable of tightly regulating the nucleotide-bound and substrate- bound state of DnaK in ways that are necessary for the normal housekeeping functions and stress-related functions of the DnaK molecular chaperone cycle; chaperone protein DnaK complement(2840534..2842387) Arthrobacter arilaitensis Re117 9793939 YP_003917721.1 CDS AARI_25340 NC_014550.1 2842561 2842869 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2842561..2842869 Arthrobacter arilaitensis Re117 9793826 YP_003917722.1 CDS AARI_25380 NC_014550.1 2849137 2850684 R DEAD box helicase. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression; ATP-dependent RNA helicase complement(2849137..2850684) Arthrobacter arilaitensis Re117 9795028 YP_003917723.1 CDS AARI_25390 NC_014550.1 2850986 2853127 R Resistance-Nodulation-Cell Division (RND) superfamily (TC 2.A.6.y.z); drug exporter of the RND superfamily complement(2850986..2853127) Arthrobacter arilaitensis Re117 9795029 YP_003917724.1 CDS AARI_25400 NC_014550.1 2853258 2853746 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 2853258..2853746 Arthrobacter arilaitensis Re117 9795030 YP_003917725.1 CDS AARI_25410 NC_014550.1 2853767 2854390 D resistance to homoSer/Thr (RhtB) family protein (TC 2.A.76.y.z). The family includes homoserine, threonine and leucine efflux proteins. The transport reaction presumably catalyzed by members of the RhtB family is: amino acid (in) + nH+ (out) <--> amino acid (out) + nH+ (in); RHBT family amino acid transporter 2853767..2854390 Arthrobacter arilaitensis Re117 9795031 YP_003917726.1 CDS AARI_25420 NC_014550.1 2854530 2855039 D identified by match to protein family PF01451. Protein tyrosine (pTyr) phosphorylation is a common post- translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; EC:3.1.3.48) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation. Low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatase) act on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; low molecular weight protein-tyrosine-phosphatase 2854530..2855039 Arthrobacter arilaitensis Re117 9795032 YP_003917727.1 CDS AARI_25430 NC_014550.1 2855026 2857035 D aminodeoxychorismate synthase catalyzes the biosynthesis of 4-amino-4-deoxychorismate from chorismate and glutamine. It is involved in folate biosynthesis; aminodeoxychorismate synthase 2855026..2857035 Arthrobacter arilaitensis Re117 9795033 YP_003917728.1 CDS cls NC_014550.1 2857039 2858511 R cardiolipin synthase catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthase complement(2857039..2858511) Arthrobacter arilaitensis Re117 9795034 YP_003917729.1 CDS pabC NC_014550.1 2858702 2859577 D aminodeoxychorismate lyase converts 4- aminodeoxychorismate to pyruvate and p-aminobenzoate, a precursor of folic acid in bacteria; aminodeoxychorismate lyase 2858702..2859577 Arthrobacter arilaitensis Re117 9793744 YP_003917730.1 CDS AARI_25460 NC_014550.1 2859574 2861901 R TC 3.A.1.y.z. ABCISSE for N-terminal section of the protein: ABC transporter, fused ATP-binding protein (ABC2), CBY-family (Cobalt uptake, unknown), Y179- subfamily (CBU-like systems); C-terminal section of the protein: permease (IM), CBY-family, Y179-subfamily. The function of CBU-like systems is unknown; ABC transporter inner membrane and ATP-binding subunits complement(2859574..2861901) Arthrobacter arilaitensis Re117 9794172 YP_003917731.1 CDS AARI_25470 NC_014550.1 2861898 2862506 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2861898..2862506) Arthrobacter arilaitensis Re117 9795035 YP_003917732.1 CDS AARI_25480 NC_014550.1 2862776 2863018 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2862776..2863018 Arthrobacter arilaitensis Re117 9795036 YP_003917733.1 CDS mnhG NC_014550.1 2863078 2863482 R identified by match to protein family PF03334. Na(+)/H(+) antiporters has several roles in bacterial cells: (i) establishment of an electrochemical potential of Na(+) across the cytoplasmic membrane, which is the driving force for Na(+)-coupled processes such as Na(+)/solute symport and Na(+)-driven flagellar rotation; (ii) extrusion of Na(+) and Li(+), which are toxic if accumulated at high concentrations in cells; (iii) intracellular pH regulation under alkaline conditions; and (iv) cell volume regulation; Na(+)/H(+) antiporter subunit G complement(2863078..2863482) Arthrobacter arilaitensis Re117 9795037 YP_003917734.1 CDS mnhF NC_014550.1 2863482 2863748 R Na(+)/H(+) antiporters has several roles in bacterial cells: (i) establishment of an electrochemical potential of Na(+) across the cytoplasmic membrane, which is the driving force for Na(+)-coupled processes such as Na(+)/solute symport and Na(+)-driven flagellar rotation; (ii) extrusion of Na(+) and Li(+), which are toxic if accumulated at high concentrations in cells; (iii) intracellular pH regulation under alkaline conditions; and (iv) cell volume regulation; Na(+)/H(+) antiporter subunit F complement(2863482..2863748) Arthrobacter arilaitensis Re117 9794089 YP_003917735.1 CDS mnhE NC_014550.1 2863751 2864380 R identified by match to protein family PF01899. Na(+)/H(+) antiporters has several roles in bacterial cells: (i) establishment of an electrochemical potential of Na(+) across the cytoplasmic membrane, which is the driving force for Na(+)-coupled processes such as Na(+)/solute symport and Na(+)-driven flagellar rotation; (ii) extrusion of Na(+) and Li(+), which are toxic if accumulated at high concentrations in cells; (iii) intracellular pH regulation under alkaline conditions; and (iv) cell volume regulation; Na(+)/H(+) antiporter subunit E complement(2863751..2864380) Arthrobacter arilaitensis Re117 9794088 YP_003917736.1 CDS mnhD NC_014550.1 2864389 2865990 R Na(+)/H(+) antiporters has several roles in bacterial cells: (i) establishment of an electrochemical potential of Na(+) across the cytoplasmic membrane, which is the driving force for Na(+)-coupled processes such as Na(+)/solute symport and Na(+)-driven flagellar rotation; (ii) extrusion of Na(+) and Li(+), which are toxic if accumulated at high concentrations in cells; (iii) intracellular pH regulation under alkaline conditions; and (iv) cell volume regulation; Na(+)/H(+) antiporter subunit D complement(2864389..2865990) Arthrobacter arilaitensis Re117 9794087 YP_003917737.1 CDS mnhC NC_014550.1 2865987 2866436 R Na(+)/H(+) antiporters has several roles in bacterial cells: (i) establishment of an electrochemical potential of Na(+) across the cytoplasmic membrane, which is the driving force for Na(+)-coupled processes such as Na(+)/solute symport and Na(+)-driven flagellar rotation; (ii) extrusion of Na(+) and Li(+), which are toxic if accumulated at high concentrations in cells; (iii) intracellular pH regulation under alkaline conditions; and (iv) cell volume regulation; Na(+)/H(+) antiporter subunit C complement(2865987..2866436) Arthrobacter arilaitensis Re117 9794086 YP_003917738.1 CDS AARI_25540 NC_014550.1 2866433 2869402 R Na(+)/H(+) antiporters has several roles in bacterial cells: (i) establishment of an electrochemical potential of Na(+) across the cytoplasmic membrane, which is the driving force for Na(+)-coupled processes such as Na(+)/solute symport and Na(+)-driven flagellar rotation; (ii) extrusion of Na(+) and Li(+), which are toxic if accumulated at high concentrations in cells; (iii) intracellular pH regulation under alkaline conditions; and (iv) cell volume regulation; Na(+)/H(+) antiporter subunit A/B complement(2866433..2869402) Arthrobacter arilaitensis Re117 9794085 YP_003917739.1 CDS AARI_25550 NC_014550.1 2869630 2870949 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 2869630..2870949 Arthrobacter arilaitensis Re117 9795038 YP_003917740.1 CDS dcd NC_014550.1 2871023 2871604 R catalyses the formation of dUMP from dCTP; dCTP deaminase complement(2871023..2871604) Arthrobacter arilaitensis Re117 9795039 YP_003917741.1 CDS AARI_25570 NC_014550.1 2871793 2872650 D identified by match to protein family PF02557; D-alanyl-D-alanine carboxypeptidase 2871793..2872650 Arthrobacter arilaitensis Re117 9793794 YP_003917742.1 CDS AARI_25580 NC_014550.1 2872657 2872998 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2872657..2872998) Arthrobacter arilaitensis Re117 9795040 YP_003917743.1 CDS AARI_25590 NC_014550.1 2873160 2874866 R catalyzes the reversible hydration of fumarate to L- malate. Involved in the TCA cycle; fumarate hydratase class I complement(2873160..2874866) Arthrobacter arilaitensis Re117 9795041 YP_003917744.1 CDS AARI_25600 NC_014550.1 2874978 2875463 D hypothetical protein 2874978..2875463 Arthrobacter arilaitensis Re117 9795042 YP_003917745.1 CDS AARI_25610 NC_014550.1 2875711 2876640 D Auxin Efflux Carrier (AEC) Family (TC 2.A.69.y.z). Homologues of the AEC family are found in bacteria as well as in archaea. The K. pneumoniae homologues has been implicated in malonate uptake, the O. oeni homologue is a malate permease; RHBT family transporter 2875711..2876640 Arthrobacter arilaitensis Re117 9793643 YP_003917746.1 CDS tcyA NC_014550.1 2876726 2877553 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family, glutamate porter (TC 3.A.1.3.14). ABCISSE: ABC transporter, binding protein (BP), PAO-family (polar amino acid and opines), L- cystine impot. Part of the ABC transporter complex TcyABC involved in L-cystine import. Identified by similarity to protein SP:P94402 (Bacillus subtilis); L-cystine ABC transporter substrate-binding protein TcyA 2876726..2877553 Arthrobacter arilaitensis Re117 9795044 YP_003917747.1 CDS tcyB NC_014550.1 2877625 2878290 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family, glutamate porter (TC 3.A.1.3.14). ABCISSE: ABC transporter, permease (IM), PAO-family (polar amino acid and opines), L-cystine impot. Part of the ABC transporter complex TcyABC involved in L-cystine import. Identified by similarity to protein SP:P42200 (Bacillus subtilis); L-cystine ABC transporter inner membrane subunit TcyB 2877625..2878290 Arthrobacter arilaitensis Re117 9794431 YP_003917748.1 CDS tcyC NC_014550.1 2878277 2879041 D TCDB: ATP-binding cassette (ABC) superfamily, polar amino acid uptake transporter (PAAT) family, glutamate porter (TC 3.A.1.3.14). ABCISSE: ABC transporter, ATP- binding protein (ABC), PAO-family (polar amino acid and opines), L-cystine impot. Part of the ABC transporter complex TcyABC involved in L-cystine import. Identified by similarity to protein SP:P39456 (Bacillus subtilis); L-cystine ABC transporter ATP-binding subunit TcyC 2878277..2879041 Arthrobacter arilaitensis Re117 9794432 YP_003917749.1 CDS AARI_25650 NC_014550.1 2879060 2880589 D hypothetical protein 2879060..2880589 Arthrobacter arilaitensis Re117 9794433 YP_003917750.1 CDS AARI_25660 NC_014550.1 2880705 2880938 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2880705..2880938 Arthrobacter arilaitensis Re117 9795045 YP_003917751.1 CDS AARI_25670 NC_014550.1 2881121 2882143 D hypothetical protein 2881121..2882143 Arthrobacter arilaitensis Re117 9795046 YP_003917752.1 CDS AARI_25680 NC_014550.1 2882140 2883378 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(2882140..2883378) Arthrobacter arilaitensis Re117 9795047 YP_003917753.1 CDS AARI_25690 NC_014550.1 2883536 2885443 R match to PF01436: NHL repeat; NHL repeat-containing protein complement(2883536..2885443) Arthrobacter arilaitensis Re117 9795048 YP_003917754.1 CDS AARI_25700 NC_014550.1 2885591 2886352 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.474 between position 26 and 27; hypothetical protein complement(2885591..2886352) Arthrobacter arilaitensis Re117 9795049 YP_003917755.1 CDS AARI_25710 NC_014550.1 2886345 2888399 R identified by match to protein family PF05425. Copper sequestering activity displayed by some bacteria is determined by copper-binding protein products of the copper resistance operon (cop). CopD, together with CopC, perform copper uptake into the cytoplasm; copper resistance protein D complement(2886345..2888399) Arthrobacter arilaitensis Re117 9795050 YP_003917756.1 CDS AARI_25720 NC_014550.1 2888474 2889628 R identified by match to protein family PF04261. This family of dye-decolourising peroxidases lack a typical heme-binding region; Dyp-type peroxidase family protein complement(2888474..2889628) Arthrobacter arilaitensis Re117 9795051 YP_003917757.1 CDS AARI_25730 NC_014550.1 2889615 2890133 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.391 between position 26 and 27; hypothetical protein complement(2889615..2890133) Arthrobacter arilaitensis Re117 9795052 YP_003917758.1 CDS AARI_25740 NC_014550.1 2890211 2890771 R identified by match to protein family PF04234. CopC is a bacterial blue copper protein that binds 1 atom of copper per protein molecule. Along with CopA, CopC mediates copper resistance by sequestration of copper in the periplasm; copper resistance protein C complement(2890211..2890771) Arthrobacter arilaitensis Re117 9795053 YP_003917759.1 CDS AARI_25750 NC_014550.1 2890815 2891462 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2890815..2891462) Arthrobacter arilaitensis Re117 9795054 YP_003917760.1 CDS hup NC_014550.1 2891576 2891860 R histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Identified by match to protein family PF00216; DNA-binding protein HU complement(2891576..2891860) Arthrobacter arilaitensis Re117 9795055 YP_003917761.1 CDS hup NC_014550.1 2892134 2892418 R histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. Identified by match to protein family PF00216; DNA-binding protein HU complement(2892134..2892418) Arthrobacter arilaitensis Re117 9793988 YP_003917762.1 CDS AARI_25780 NC_014550.1 2892594 2893562 R identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein complement(2892594..2893562) Arthrobacter arilaitensis Re117 9793989 YP_003917763.1 CDS AARI_25790 NC_014550.1 2893667 2894248 D hypothetical protein 2893667..2894248 Arthrobacter arilaitensis Re117 9795056 YP_003917764.1 CDS rpsN NC_014550.1 2894307 2894612 R part of the 30S ribosomal subunit. Contacts proteins S3 and S10; 30S ribosomal protein S14 complement(2894307..2894612) Arthrobacter arilaitensis Re117 9795057 YP_003917765.1 CDS rpmG NC_014550.1 2894616 2894786 R part of the 50S ribosomal subunit. Cross-links to the P and E site tRNAs; 50S ribosomal protein L33 complement(2894616..2894786) Arthrobacter arilaitensis Re117 9794361 YP_003917766.1 CDS rpmB NC_014550.1 2894789 2895025 R 50S ribosomal protein L28 complement(2894789..2895025) Arthrobacter arilaitensis Re117 9794339 YP_003917767.1 CDS AARI_25830 NC_014550.1 2895354 2895854 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(2895354..2895854) Arthrobacter arilaitensis Re117 9794334 YP_003917768.1 CDS AARI_25840 NC_014550.1 2896228 2897025 R TCDB: ATP-binding cassette (ABC) superfamily, Polyamine/Opine/Phosphonate Uptake Transporter (POPT) Family (TC 3.A.1.11.z). ABCISSE: ABC transporter, permease (IM), MOI-family, polyamine import. Part of an ABC transporter complex involved in import of polyamine (such as spermidine or putrescine); polyamine ABC transporter inner membrane subunit complement(2896228..2897025) Arthrobacter arilaitensis Re117 9795058 YP_003917769.1 CDS AARI_25850 NC_014550.1 2897027 2897950 R TCDB: ATP-binding cassette (ABC) superfamily, Polyamine/Opine/Phosphonate Uptake Transporter (POPT) Family (TC 3.A.1.11.z). ABCISSE: ABC transporter, permease (IM), MOI-family, polyamine import. Part of an ABC transporter complex involved in import of polyamine (such as spermidine or putrescine); polyamine ABC transporter inner membrane subunit complement(2897027..2897950) Arthrobacter arilaitensis Re117 9795059 YP_003917770.1 CDS AARI_25860 NC_014550.1 2897947 2899080 R TCDB: ATP-binding cassette (ABC) superfamily, Polyamine/Opine/Phosphonate Uptake Transporter (POPT) Family (TC 3.A.1.11.z). ABCISSE: ABC transporter, ATP- binding protein (ABC), MOI-family, polyamine import. Part of an ABC transporter complex involved in import of polyamine (such as spermidine or putrescine); polyamine ABC transporter ATP-binding subunit complement(2897947..2899080) Arthrobacter arilaitensis Re117 9795060 YP_003917771.1 CDS AARI_25870 NC_014550.1 2899077 2900300 R TCDB: ATP-binding cassette (ABC) superfamily, Polyamine/Opine/Phosphonate Uptake Transporter (POPT) Family (TC 3.A.1.11.z). ABCISSE: ABC transporter, binding protein (BP), MOI-family, polyamine import. Part of an ABC transporter complex involved in import of polyamine (such as spermidine or putrescine); polyamine ABC transporter substrate-binding protein complement(2899077..2900300) Arthrobacter arilaitensis Re117 9795061 YP_003917772.1 CDS AARI_25880 NC_014550.1 2900316 2901545 R TCDB: ATP-binding cassette (ABC) superfamily, Polyamine/Opine/Phosphonate Uptake Transporter (POPT) Family (TC 3.A.1.11.z). ABCISSE: ABC transporter, binding protein (BP), MOI-family, polyamine import. Part of an ABC transporter complex involved in import of polyamine (such as spermidine or putrescine); polyamine ABC transporter substrate-binding protein complement(2900316..2901545) Arthrobacter arilaitensis Re117 9795062 YP_003917773.1 CDS AARI_25890 NC_014550.1 2901761 2902228 D identified by match to protein family PF01037: AsnC_trans_reg, AsnC family; AsnC/Lrp family transcriptional regulator 2901761..2902228 Arthrobacter arilaitensis Re117 9795063 YP_003917774.1 CDS AARI_25900 NC_014550.1 2902225 2903604 D identified by match to protein family PF00202: aminotransferase class-III; aminotransferase 2902225..2903604 Arthrobacter arilaitensis Re117 9795064 YP_003917775.1 CDS AARI_25910 NC_014550.1 2903762 2904820 D match to PS00142 pattern: neutral zinc metallopeptidases, zinc-binding region signature; hypothetical protein 2903762..2904820 Arthrobacter arilaitensis Re117 9795065 YP_003917776.1 CDS AARI_25920 NC_014550.1 2904850 2906502 R identified by match to cd00085: HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins; HNH endonuclease domain-containing protein complement(2904850..2906502) Arthrobacter arilaitensis Re117 9795066 YP_003917777.1 CDS AARI_25930 NC_014550.1 2906565 2908079 R match to protein family PF07905: purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR, O32138). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being regulatory proteins; transcriptional regulator complement(2906565..2908079) Arthrobacter arilaitensis Re117 9795067 YP_003917778.1 CDS msmA NC_014550.1 2908200 2909702 D methylmalonate-semialdehyde dehydrogenase catalyses the following reaction: 2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) <=> propanoyl-CoA + HCO(3)(-) + NADH. Involved in the catabolism of valine; methylmalonate-semialdehyde dehydrogenase 2908200..2909702 Arthrobacter arilaitensis Re117 9795068 YP_003917779.1 CDS AARI_25950 NC_014550.1 2909707 2911074 D identified by match to protein family PF00202: aminotransferase class-III; aminotransferase 2909707..2911074 Arthrobacter arilaitensis Re117 9794110 YP_003917780.1 CDS AARI_25960 NC_014550.1 2911132 2912490 D identified by match to PF02913 and PF01565; FAD linked oxidase domain-containing protein 2911132..2912490 Arthrobacter arilaitensis Re117 9795069 YP_003917781.1 CDS AARI_25970 NC_014550.1 2912529 2912966 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2912529..2912966 Arthrobacter arilaitensis Re117 9795070 YP_003917782.1 CDS AARI_25980 NC_014550.1 2913060 2913536 D hypothetical protein 2913060..2913536 Arthrobacter arilaitensis Re117 9795071 YP_003917783.1 CDS AARI_25990 NC_014550.1 2913937 2914104 D hypothetical protein 2913937..2914104 Arthrobacter arilaitensis Re117 9795072 YP_003917784.1 CDS AARI_26000 NC_014550.1 2914128 2914967 R shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone; shikimate dehydrogenase-like protein complement(2914128..2914967) Arthrobacter arilaitensis Re117 9795073 YP_003917785.1 CDS arr NC_014550.1 2915046 2915456 D similar to Mycobacterium smegmatis rifampin ADP- ribosyl transferase (AF001493). Inactivates rifampin by ribosylation; rifampin ADP-ribosyl transferase 2915046..2915456 Arthrobacter arilaitensis Re117 9795074 YP_003917786.1 CDS AARI_26020 NC_014550.1 2915532 2916944 R aldehyde dehydrogenase family protein complement(2915532..2916944) Arthrobacter arilaitensis Re117 9793690 YP_003917787.1 CDS AARI_26030 NC_014550.1 2916970 2918400 R amino acid-polyamine-organocation (APC) Superfamily (TC 2.A.3.y.z); amino acid transporter complement(2916970..2918400) Arthrobacter arilaitensis Re117 9795075 YP_003917788.1 CDS AARI_26040 NC_014550.1 2918513 2919436 R identified by match to protein domain PF00165: bacterial regulatory helix-turn-helix proteins, AraC family; AraC family transcriptional regulator complement(2918513..2919436) Arthrobacter arilaitensis Re117 9795076 YP_003917789.1 CDS AARI_26050 NC_014550.1 2919539 2920132 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(2919539..2920132) Arthrobacter arilaitensis Re117 9795077 YP_003917790.1 CDS AARI_26060 NC_014550.1 2920262 2922184 D catalyses the oxidative deamination of primary amines (such as biogenic amines) to the corresponding aldehydes, with concomitant reduction of molecular oxygen to hydrogen peroxide. Identified by similarity to protein SP:P46881 (Arthrobacter globiformis); primary-amine oxidase 2920262..2922184 Arthrobacter arilaitensis Re117 9795078 YP_003917791.1 CDS AARI_26070 NC_014550.1 2922159 2922608 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2922159..2922608 Arthrobacter arilaitensis Re117 9795079 YP_003917792.1 CDS AARI_26080 NC_014550.1 2922885 2924330 D FAD-dependent oxidoreductase 2922885..2924330 Arthrobacter arilaitensis Re117 9795080 YP_003917793.1 CDS AARI_26090 NC_014550.1 2924330 2924698 D hypothetical protein 2924330..2924698 Arthrobacter arilaitensis Re117 9795081 YP_003917794.1 CDS AARI_26100 NC_014550.1 2924719 2926209 D identified by match to protein family PF00171; aldehyde dehydrogenase family protein 2924719..2926209 Arthrobacter arilaitensis Re117 9795082 YP_003917795.1 CDS AARI_26110 NC_014550.1 2926196 2927338 R match to protein family PF04464. Possibly involved in teichoic acid biosynthesis; transferase complement(2926196..2927338) Arthrobacter arilaitensis Re117 9795083 YP_003917796.1 CDS AARI_26120 NC_014550.1 2927358 2928419 R TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, binding protein (BP), MET-family. This family is comprised of systems involved in the uptake of various metallic cations such as iron, manganese and zinc; iron/manganese/zinc ABC transporter substrate-binding protein complement(2927358..2928419) Arthrobacter arilaitensis Re117 9795084 YP_003917797.1 CDS AARI_26130 NC_014550.1 2928488 2929741 R identified by match to protein family PF07907. The sequences featured in this family are similar to two proteins expressed by Lactococcus lactis, YibE and YibF. Most of the members of this family are annotated as being membrane proteins, and in fact the sequences contain a high proportion of hydrophobic residues; YibE/F family protein complement(2928488..2929741) Arthrobacter arilaitensis Re117 9795085 YP_003917798.1 CDS AARI_26140 NC_014550.1 2929928 2931085 D 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2929928..2931085 Arthrobacter arilaitensis Re117 9795086 YP_003917799.1 CDS AARI_26150 NC_014550.1 2931141 2932196 R hypothetical protein complement(2931141..2932196) Arthrobacter arilaitensis Re117 9795087 YP_003917800.1 CDS AARI_26160 NC_014550.1 2932412 2933521 R match to protein family PF00724: NADH:flavin oxidoreductase / NADH oxidase family; flavin oxidoreductase complement(2932412..2933521) Arthrobacter arilaitensis Re117 9795088 YP_003917801.1 CDS AARI_26170 NC_014550.1 2933580 2934935 R TCDB: Mg2+ Transporter-E (MgtE) Family (TC 9.A.19.y. z). Proteins from this family are capable of transporting Mg2+ and Co2+ but not Ni2+; divalent cation transporter complement(2933580..2934935) Arthrobacter arilaitensis Re117 9795089 YP_003917802.1 CDS sdaA NC_014550.1 2935350 2936759 R catalyzes the dehydratation of L-serine into ammonia and pyruvate; L-serine ammonia-lyase complement(2935350..2936759) Arthrobacter arilaitensis Re117 9795090 YP_003917803.1 CDS glyA NC_014550.1 2936948 2938270 R catalyzes the transfer of the hydroxymethyl group of serine to tetrahydrofolate to form 5,10- methylenetetrahydrofolate and glycine. Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine; glycine hydroxymethyltransferase complement(2936948..2938270) Arthrobacter arilaitensis Re117 9794380 YP_003917804.1 CDS gcvH NC_014550.1 2938270 2938650 R glycine cleavage system H protein complement(2938270..2938650) Arthrobacter arilaitensis Re117 9793926 YP_003917805.1 CDS gcvT NC_014550.1 2938712 2939839 R a component, with EC 1.4.4.2, EC 1.8.1.4 and the lipoyl-bearing H protein, of the glycine cleavage system, which catalyzes the oxidative cleavage of glycine to form NH3, C02, and 5,10-methylenetetrahydrofolate; aminomethyltransferase complement(2938712..2939839) Arthrobacter arilaitensis Re117 9793892 YP_003917806.1 CDS gcvP NC_014550.1 2939853 2942699 R a component, with EC 2.1.2.10 and EC 1.8.1.4, of the glycine cleavage system; glycine dehydrogenase complement(2939853..2942699) Arthrobacter arilaitensis Re117 9793894 YP_003917807.1 CDS AARI_26230 NC_014550.1 2943064 2943840 R identified by match to protein family PF00657; GDSL-like lipase/esterase complement(2943064..2943840) Arthrobacter arilaitensis Re117 9793893 YP_003917808.1 CDS AARI_26240 NC_014550.1 2943908 2945059 R identified by similarity to protein SP:Q44050 (Arthrobacter globiformis); carboxylesterase complement(2943908..2945059) Arthrobacter arilaitensis Re117 9795091 YP_003917809.1 CDS AARI_26250 NC_014550.1 2945286 2946773 D amino acid-polyamine-organocation (APC) Superfamily (TC 2.A.3.y.z); amino acid transporter 2945286..2946773 Arthrobacter arilaitensis Re117 9795092 YP_003917810.1 CDS AARI_26260 NC_014550.1 2946837 2947748 R ribonuclease H recognizes and cleaves the RNA strand of RNA-DNA heteroduplexes; ribonuclease H complement(2946837..2947748) Arthrobacter arilaitensis Re117 9795093 YP_003917811.1 CDS AARI_26270 NC_014550.1 2947866 2948174 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.703) with cleavage site probability 0.284 between position 33 and 34; hypothetical protein 2947866..2948174 Arthrobacter arilaitensis Re117 9795094 YP_003917812.1 CDS AARI_26280 NC_014550.1 2948243 2949352 R glutathione transferase is involved in cellular detoxification by catalyzing the conjugation of glutathione with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress; glutathione transferase complement(2948243..2949352) Arthrobacter arilaitensis Re117 9795095 YP_003917813.1 CDS AARI_26290 NC_014550.1 2949493 2949585 R hypothetical protein complement(2949493..2949585) Arthrobacter arilaitensis Re117 9795096 YP_003917814.1 CDS AARI_26300 NC_014550.1 2949749 2950234 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 2949749..2950234 Arthrobacter arilaitensis Re117 9795097 YP_003917815.1 CDS AARI_26310 NC_014550.1 2950231 2952060 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, prokaryote drug export (PED) subfamily. Possible function in in antibiotic peptide or drug resistance or production (export); drug resistance ATP-binding protein complement(2950231..2952060) Arthrobacter arilaitensis Re117 9795098 YP_003917816.1 CDS AARI_26320 NC_014550.1 2952166 2952642 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 2952166..2952642 Arthrobacter arilaitensis Re117 9795099 YP_003917817.1 CDS AARI_26330 NC_014550.1 2952667 2954574 R N-terminal part of the protein: iron-siderophore ABC transporter, ATP-binding subunit. TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), ISVH-family (iron siderophores, vitamin B12 and hemin). C-terminal part of the protein: siderophore-interacting protein. Possibly involved in removal of iron from iron-siderophore complexes; iron-siderophore uptake protein complement(2952667..2954574) Arthrobacter arilaitensis Re117 9795100 YP_003917818.1 CDS AARI_26340 NC_014550.1 2954577 2955668 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(2954577..2955668) Arthrobacter arilaitensis Re117 9795101 YP_003917819.1 CDS AARI_26350 NC_014550.1 2955680 2956729 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(2955680..2956729) Arthrobacter arilaitensis Re117 9795102 YP_003917820.1 CDS AARI_26360 NC_014550.1 2956750 2957550 D identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase 2956750..2957550 Arthrobacter arilaitensis Re117 9795103 YP_003917821.1 CDS AARI_26370 NC_014550.1 2957557 2958615 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(2957557..2958615) Arthrobacter arilaitensis Re117 9795104 YP_003917822.1 CDS AARI_26380 NC_014550.1 2958806 2960131 R match to PF02687: this is a family of predicted permeases and hypothetical transmembrane proteins; permease complement(2958806..2960131) Arthrobacter arilaitensis Re117 9795105 YP_003917823.1 CDS AARI_26390 NC_014550.1 2960128 2960871 R TCDB: ATP-binding cassette (ABC) superfamily (TC 3. A.1.y.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), o228 family (members of this family might be involved in a more general lipoprotein releasing mechanism common to all prokaryotes); ABC transporter ATP-binding subunit complement(2960128..2960871) Arthrobacter arilaitensis Re117 9795106 YP_003917824.1 CDS AARI_26400 NC_014550.1 2961046 2961264 D hypothetical protein 2961046..2961264 Arthrobacter arilaitensis Re117 9795107 YP_003917825.1 CDS AARI_26410 NC_014550.1 2961338 2961973 D hypothetical protein 2961338..2961973 Arthrobacter arilaitensis Re117 9795108 YP_003917826.1 CDS AARI_26420 NC_014550.1 2962042 2963136 R identified by match to PF00924: mechanosensitive ion channel. Mechanosensitive channels provide protection against hypo-osmotic shock, responding both to stretching of the cell membrane and to membrane depolarisation. Two members of this protein family: Q57634 and Q58543 of M. jannaschii have been functionally characterised. Both proteins form mechanosensitive ion channels upon reconstitution into liposomes and functional examination by the patch-clamp technique. Therefore this family are likely to also be MS channel proteins. . TC 1.A.23.y.z (Small Conductance Mechanosensitive Ion Channel (MscS) Family); MscS mechanosensitive ion channel protein complement(2962042..2963136) Arthrobacter arilaitensis Re117 9795109 YP_003917827.1 CDS AARI_26430 NC_014550.1 2963348 2963893 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.468 between position 31 and 32; hypothetical protein 2963348..2963893 Arthrobacter arilaitensis Re117 9795110 YP_003917828.1 CDS AARI_26440 NC_014550.1 2963980 2964987 D identified by match to protein family PF02567. PhzC/PhzF is involved in dimerisation of two 2, 3-dihydro-3- oxo-anthranilic acid molecules to create phenazine-1- carboxylic acid (PCA) by P. fluorescens. This family also contains a thymidilate synthase from Mycobacterium tuberculosis. Many phenazine compounds are found in nature and are produced by bacteria such as Pseudomonas spp., Streptomyces spp., and Pantoea agglomerans. These compounds have been implicated in the virulence and competitive fitness of producing organisms. For example, the phenazine pyocyanin produced by Pseudomonas aeruginosa contributes to its ability to colonise the lungs of cystic fibrosis patients. Similarly, phenazine-1-carboxylic acid, produced by a number of Pseudomonas, increases survival in soil environments and has been shown to be essential for the biological control activity of certain strains; phenazine biosynthesis protein PhzC/PhzF 2963980..2964987 Arthrobacter arilaitensis Re117 9795111 YP_003917829.1 CDS AARI_26450 NC_014550.1 2965049 2966500 D major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z). Identified by match to protein family TIGR00711; EmrB/QacA subfamily drug resistance transporter 2965049..2966500 Arthrobacter arilaitensis Re117 9795112 YP_003917830.1 CDS AARI_26460 NC_014550.1 2966580 2966771 R hypothetical protein complement(2966580..2966771) Arthrobacter arilaitensis Re117 9795113 YP_003917831.1 CDS AARI_26470 NC_014550.1 2966876 2967307 R hypothetical protein complement(2966876..2967307) Arthrobacter arilaitensis Re117 9795114 YP_003917832.1 CDS AARI_26480 NC_014550.1 2967469 2968158 D match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator 2967469..2968158 Arthrobacter arilaitensis Re117 9795115 YP_003917833.1 CDS AARI_26490 NC_014550.1 2968261 2969493 D possibly involved in the metabolism of lipids. Match to protein domains PF08028, PF02771 and PF02770. Acyl-CoA dehydrogenases catalyze the alpha,beta- dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase 2968261..2969493 Arthrobacter arilaitensis Re117 9795116 YP_003917834.1 CDS AARI_26500 NC_014550.1 2969559 2972117 R match to protein family TIGR01970: ATP-dependent helicase HrpB; ATP-dependent RNA helicase complement(2969559..2972117) Arthrobacter arilaitensis Re117 9795117 YP_003917835.1 CDS AARI_26510 NC_014550.1 2972114 2972899 R match to PF00561: alpha/beta hydrolase fold. This catalytic domain is found in a very wide range of enzymes; hydrolase complement(2972114..2972899) Arthrobacter arilaitensis Re117 9795118 YP_003917836.1 CDS AARI_26520 NC_014550.1 2973052 2973213 D hypothetical protein 2973052..2973213 Arthrobacter arilaitensis Re117 9795119 YP_003917837.1 CDS AARI_26530 NC_014550.1 2973514 2974575 D identified by match to PF00248 family: Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity; aldo-keto reductase family protein 2973514..2974575 Arthrobacter arilaitensis Re117 9795120 YP_003917838.1 CDS gabD NC_014550.1 2974848 2976230 D succinate-semialdehyde dehydrogenase (NAD(P)(+)) reduces succinate semialdehyde into succinate. Involved in the degradation of gamma-aminobutyrate; succinate-semialdehyde dehydrogenase 2974848..2976230 Arthrobacter arilaitensis Re117 9795121 YP_003917839.1 CDS AARI_26550 NC_014550.1 2976332 2977264 R 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2976332..2977264) Arthrobacter arilaitensis Re117 9793876 YP_003917840.1 CDS AARI_26560 NC_014550.1 2977396 2977605 R hypothetical protein complement(2977396..2977605) Arthrobacter arilaitensis Re117 9795122 YP_003917841.1 CDS AARI_26570 NC_014550.1 2978268 2983022 R match to protein domain PF00746: Gram positive anchor. Surface proteins from Gram-positive cocci are covalently linked to the bacterial cell wall by sortase, a membrane-anchored transpeptidase that cleaves proteins between the threonine and the glycine of a conserved LPxTG motif, with the formation of a thioester between the conserved cysteine of sortase and the threonine carboxyl group. The newly liberated C-terminus of the threonine is transferred via an amide bond exchange to the amino group of the pentaglycine wall crossbridge, thereby tethering the C-terminus end of the surface protein to the bacterial peptidoglycan.The proteins that contain the conserved hexapeptide and hydrophobic anchor are diverse: they include M proteins, IgA and IgG binding proteins, fibronectin-binding proteins, wall-associated proteins, trypsin-resistant surface T protein, protein H precursor, etc. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.981 between position 35 and 36; cell surface protein complement(2978268..2983022) Arthrobacter arilaitensis Re117 9795123 YP_003917842.1 CDS AARI_26580 NC_014550.1 2983442 2984107 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 2983442..2984107 Arthrobacter arilaitensis Re117 9795124 YP_003917843.1 CDS AARI_26590 NC_014550.1 2984125 2984847 R match to PF08239: bacterial SH3 domain. A homologue of the SH3 domain has been found in a number of different bacterial proteins including glycyl-glycine endopeptidase, bacteriocin and some hypothetical proteins; SH3 domain-containing protein complement(2984125..2984847) Arthrobacter arilaitensis Re117 9795125 YP_003917844.1 CDS AARI_26600 NC_014550.1 2984939 2985439 R identified by match to PF00210. Ferritin is one of the major non-haem iron storage proteins in animals, plants, and microorganisms. It consists of a mineral core of hydrated ferric oxide, and a multi-subunit protein shell that encloses the former and assures its solubility in an aqueous environment; ferritin-like protein complement(2984939..2985439) Arthrobacter arilaitensis Re117 9795126 YP_003917845.1 CDS AARI_26610 NC_014550.1 2985585 2988014 R match to protein family PTHR10724: Tex protein- related transcription accessory protein; transcriptional accessory protein complement(2985585..2988014) Arthrobacter arilaitensis Re117 9795127 YP_003917846.1 CDS AARI_26620 NC_014550.1 2988108 2988461 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.877 between position 34 and 35; hypothetical protein 2988108..2988461 Arthrobacter arilaitensis Re117 9795128 YP_003917847.1 CDS AARI_26630 NC_014550.1 2988505 2988915 D match to protein domain PF01479. The S4 domain was detected in proteins such as the bacterial ribosomal protein S4, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. The S4 domain probably mediates binding to RNA; S4 domain-containing protein 2988505..2988915 Arthrobacter arilaitensis Re117 9795129 YP_003917848.1 CDS AARI_26640 NC_014550.1 2988912 2990861 R identified by match to protein family PF00326. Prolyl oligopeptidase family consist of a number of evolutionary related peptidases whose catalytic activity seems to be provided by a charge relay system similar to that of the trypsin family of serine proteases, but which evolved by independent convergent evolutionidentified by match to protein family PF00326. Prolyl oligopeptidase family consist of a number of evolutionary related peptidases whose catalytic activity seems to be provided by a charge relay system similar to that of the trypsin family of serine proteases, but which evolved by independent convergent evolution; prolyl oligopeptidase family protein complement(2988912..2990861) Arthrobacter arilaitensis Re117 9795130 YP_003917849.1 CDS AARI_26650 NC_014550.1 2990937 2991476 D hypothetical protein 2990937..2991476 Arthrobacter arilaitensis Re117 9795131 YP_003917850.1 CDS AARI_26660 NC_014550.1 2991536 2992192 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 2991536..2992192 Arthrobacter arilaitensis Re117 9795132 YP_003917851.1 CDS AARI_26670 NC_014550.1 2992189 2993445 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(2992189..2993445) Arthrobacter arilaitensis Re117 9795133 YP_003917852.1 CDS AARI_26680 NC_014550.1 2993460 2994017 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(2993460..2994017) Arthrobacter arilaitensis Re117 9795134 YP_003917853.1 CDS AARI_26690 NC_014550.1 2994150 2995667 D major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z). Identified by match to protein family TIGR00711; EmrB/QacA subfamily drug resistance transporter 2994150..2995667 Arthrobacter arilaitensis Re117 9795135 YP_003917854.1 CDS AARI_26700 NC_014550.1 2995962 2996165 D match to PF00313: cold-shock DNA-binding domain. The so-called cold shock proteins are thought to help the cell to survive in temperatures lower than optimum growth temperature, by contrast with heat shock proteins, which help the cell to survive in temperatures greater than the optimum, possibly by condensation of the chromosome and organization of the prokaryotic nucleoid; cold shock protein 2995962..2996165 Arthrobacter arilaitensis Re117 9795136 YP_003917855.1 CDS AARI_26710 NC_014550.1 2996292 2997284 D identified by match to PF00296. Bacterial luciferase is a flavin monooxygenase that catalyses the oxidation of long-chain aldehydes and releases energy in the form of visible light, and which uses flavin as a substrate rather than a cofactor. There are structural similarities between bacterial luciferase and nonfluorescent flavoproteins (LuxF, FP390), alkanesulfonate monooxygenase (SsuD), and coenzyme F420- dependent terahydromethanopterin reductase, which make up clearly related families with somewhat different folds; luciferase-like monooxygenase 2996292..2997284 Arthrobacter arilaitensis Re117 9795137 YP_003917856.1 CDS AARI_26720 NC_014550.1 2997271 2997753 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(2997271..2997753) Arthrobacter arilaitensis Re117 9795138 YP_003917857.1 CDS AARI_26730 NC_014550.1 2997775 2999013 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(2997775..2999013) Arthrobacter arilaitensis Re117 9795139 YP_003917858.1 CDS AARI_26740 NC_014550.1 2999260 2999733 D identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator 2999260..2999733 Arthrobacter arilaitensis Re117 9795140 YP_003917859.1 CDS AARI_26750 NC_014550.1 2999869 3000132 D hypothetical protein 2999869..3000132 Arthrobacter arilaitensis Re117 9795141 YP_003917860.1 CDS AARI_26760 NC_014550.1 3000178 3001083 D identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator 3000178..3001083 Arthrobacter arilaitensis Re117 9795142 YP_003917861.1 CDS AARI_26770 NC_014550.1 3001143 3002207 D enoyl-CoA hydratase catalyzes the hydratation of 2- trans-enoyl-CoA into 3-hydroxyacyl-CoA; enoyl-CoA hydratase 3001143..3002207 Arthrobacter arilaitensis Re117 9795143 YP_003917862.1 CDS AARI_35610 NC_014550.1 3002731 3004038 D transposase of ISAar19, ISL3 family 3002731..3004038 Arthrobacter arilaitensis Re117 9795145 YP_003917863.1 CDS AARI_26800 NC_014550.1 3005487 3007247 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family; ABC transporter ATPase and permease components complement(3005487..3007247) Arthrobacter arilaitensis Re117 9795146 YP_003917864.1 CDS AARI_26810 NC_014550.1 3007247 3008986 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family; ABC transporter ATPase and permease components complement(3007247..3008986) Arthrobacter arilaitensis Re117 9795147 YP_003917865.1 CDS AARI_26820 NC_014550.1 3009105 3010091 D match to protein domain PF03061: thioesterase superfamily; thioesterase family domain-containing protein 3009105..3010091 Arthrobacter arilaitensis Re117 9795148 YP_003917866.1 CDS trpF NC_014550.1 3010088 3010696 D catalyzes the following reaction: N-(5-phospho- beta-D-ribosyl)anthranilate <=> 1-(2-carboxyphenylamino)-1- deoxy-D-ribulose 5-phosphate. Involved in tryptophane biosynthesis; phosphoribosylanthranilate isomerase 3010088..3010696 Arthrobacter arilaitensis Re117 9795149 YP_003917867.1 CDS AARI_26840 NC_014550.1 3010801 3011346 R match to protein domain PF03061: thioesterase superfamily; thioesterase family domain-containing protein complement(3010801..3011346) Arthrobacter arilaitensis Re117 9794471 YP_003917868.1 CDS AARI_26850 NC_014550.1 3011503 3012873 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 4 transmembrane helices predicted by TMHMM2.0; signal transduction histidine kinase 3011503..3012873 Arthrobacter arilaitensis Re117 9795150 YP_003917869.1 CDS AARI_26860 NC_014550.1 3012870 3013535 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 3012870..3013535 Arthrobacter arilaitensis Re117 9795151 YP_003917870.1 CDS AARI_26870 NC_014550.1 3013617 3014498 D TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC), DRI-family, DRB-subfamily (drug resistance, ). Possible function in drug efflux; drug resistance ATP-binding protein 3013617..3014498 Arthrobacter arilaitensis Re117 9795152 YP_003917871.1 CDS AARI_26880 NC_014550.1 3014495 3015667 D TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM), DRI-family, DRB-subfamily (drug resistance, ). Possible function in drug efflux; drug ABC transporter inner membrane subunit 3014495..3015667 Arthrobacter arilaitensis Re117 9795153 YP_003917872.1 CDS AARI_26890 NC_014550.1 3015670 3016326 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3015670..3016326 Arthrobacter arilaitensis Re117 9795154 YP_003917873.1 CDS putA NC_014550.1 3016403 3019921 R proline dehydrogenase (EC 1.5.99.8) catalyses the following reaction: L-proline + acceptor + H(2)O <=> (S)-1- pyrroline-5-carboxylate + reduced acceptor. Pyrroline-5- carboxylate dehydrogenase (EC 1.5.1.12) catalyses the following reaction: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O <=> L-glutamate + NADH; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(3016403..3019921) Arthrobacter arilaitensis Re117 9795155 YP_003917874.1 CDS AARI_26910 NC_014550.1 3020157 3021131 D identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator 3020157..3021131 Arthrobacter arilaitensis Re117 9794260 YP_003917875.1 CDS putP NC_014550.1 3021255 3022760 D Solute:Sodium Symporter (SSS) family, Na+/proline symporter (TC 2.A.21.2.1); sodium/proline symporter 3021255..3022760 Arthrobacter arilaitensis Re117 9795156 YP_003917876.1 CDS AARI_26930 NC_014550.1 3022933 3024336 D identified by match to protein family PF01370: NAD dependent epimerase/dehydratase family. This family of proteins utilise NAD as a cofactor. The proteins in this family use nucleotide-sugar substrates for a variety of chemical reactions; NAD dependent epimerase/dehydratase family protein 3022933..3024336 Arthrobacter arilaitensis Re117 9794261 YP_003917877.1 CDS AARI_26940 NC_014550.1 3024562 3026187 D biotin carboxylase-like protein 3024562..3026187 Arthrobacter arilaitensis Re117 9795157 YP_003917878.1 CDS AARI_26950 NC_014550.1 3026177 3027406 D match to protein family HMM PF00144: beta- lactamase; hypothetical protein 3026177..3027406 Arthrobacter arilaitensis Re117 9795158 YP_003917879.1 CDS AARI_26960 NC_014550.1 3027495 3030227 R identified by match to PF01276: Orn/Lys/Arg decarboxylase, major domain; amino acid decarboxylase complement(3027495..3030227) Arthrobacter arilaitensis Re117 9795159 YP_003917880.1 CDS AARI_35620 NC_014550.1 3031273 3032580 D transposase of ISAar19, ISL3 family 3031273..3032580 Arthrobacter arilaitensis Re117 9795161 YP_003917881.1 CDS AARI_26990 NC_014550.1 3033125 3033871 D 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3033125..3033871 Arthrobacter arilaitensis Re117 9795162 YP_003917882.1 CDS AARI_27000 NC_014550.1 3033881 3034600 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3033881..3034600 Arthrobacter arilaitensis Re117 9795163 YP_003917883.1 CDS AARI_27010 NC_014550.1 3034612 3035820 D metal-dependent amidase/aminoacylase/carboxypeptidase 3034612..3035820 Arthrobacter arilaitensis Re117 9795164 YP_003917884.1 CDS AARI_27020 NC_014550.1 3036105 3036920 R match to protein family PF08282: haloacid dehalogenase-like hydrolase. The Haloacid Dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P- type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification; haloacid dehalogenase-like hydrolase complement(3036105..3036920) Arthrobacter arilaitensis Re117 9795165 YP_003917885.1 CDS ppgK NC_014550.1 3036928 3037737 R catalyzes the following reaction: (phosphate)(n) + D-glucose <=> (phosphate)(n-1) + D-glucose 6-phosphate. The polyphosphate-glucose phosphotransferase isolated from the Gram-positive bacterium Arthrobacter sp. strain KM, is a monomer that phosphorylates glucose and mannose with preference for glucose through the use of poly(P) and ATP; polyphosphate-glucose phosphotransferase complement(3036928..3037737) Arthrobacter arilaitensis Re117 9795166 YP_003917886.1 CDS AARI_27040 NC_014550.1 3037809 3038873 R transcriptional regulator complement(3037809..3038873) Arthrobacter arilaitensis Re117 9794216 YP_003917887.1 CDS AARI_27050 NC_014550.1 3038906 3040003 R catalyses the following reaction: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH; Zn-dependent alcohol dehydrogenase complement(3038906..3040003) Arthrobacter arilaitensis Re117 9795948 YP_003917888.1 CDS mmsB NC_014550.1 3040006 3040950 R catalyzes the NAD-dependent, reversible oxidation of 3-hydroxbutyrate to methylmalonate. Involved in the catabolism of valine; 3-hydroxyisobutyrate dehydrogenase complement(3040006..3040950) Arthrobacter arilaitensis Re117 9795949 YP_003917889.1 CDS AARI_27070 NC_014550.1 3041092 3042021 D identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator 3041092..3042021 Arthrobacter arilaitensis Re117 9794084 YP_003917890.1 CDS AARI_27080 NC_014550.1 3042029 3042580 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.574) with cleavage site probability 0.495 between position 29 and 30; hypothetical protein complement(3042029..3042580) Arthrobacter arilaitensis Re117 9795950 YP_003917891.1 CDS AARI_27090 NC_014550.1 3042807 3044186 R major facilitator superfamily (MFS), metabolite:H+ symporter (MHS) family (TC 2.A.1.6.z); MFS superfamily transporter complement(3042807..3044186) Arthrobacter arilaitensis Re117 9795951 YP_003917892.1 CDS AARI_27100 NC_014550.1 3044358 3044711 D match to PF05495: CHY zinc finger. This family of domains are likely to bind to zinc ions; zinc finger domain-containing protein 3044358..3044711 Arthrobacter arilaitensis Re117 9795952 YP_003917893.1 CDS AARI_27110 NC_014550.1 3044708 3045157 R identified by match to PF00582: universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general stress endurance activity; universal stress family domain-containing protein complement(3044708..3045157) Arthrobacter arilaitensis Re117 9795953 YP_003917894.1 CDS AARI_27120 NC_014550.1 3045205 3046416 R match to PF07992: pyridine nucleotide-disulphide oxidoreductase. This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases; oxidoreductase complement(3045205..3046416) Arthrobacter arilaitensis Re117 9795954 YP_003917895.1 CDS opuD NC_014550.1 3046537 3048420 R identified by similarity to protein SP:P54417 (Bacillus subtilis). betaine/carnitine/choline transporter (BCCT) family, glycine betaine:H+ symporter (TC 2.A.15.1. 1). High-affinity uptake of glycine betaine; glycine betaine transporter complement(3046537..3048420) Arthrobacter arilaitensis Re117 9795955 YP_003917896.1 CDS AARI_27140 NC_014550.1 3048678 3049859 D identified by match to PF00082. Subtilases are a family of serine proteases. The vast majority of the family are endopeptidases; subtilase family protease 3048678..3049859 Arthrobacter arilaitensis Re117 9794158 YP_003917897.1 CDS AARI_27150 NC_014550.1 3049864 3050097 D hypothetical protein 3049864..3050097 Arthrobacter arilaitensis Re117 9795956 YP_003917898.1 CDS purU NC_014550.1 3050094 3050954 R catalyses the following reaction: 10- formyltetrahydrofolate + H(2)O <=> formate + tetrahydrofolate; formyltetrahydrofolate deformylase complement(3050094..3050954) Arthrobacter arilaitensis Re117 9795957 YP_003917899.1 CDS soxG NC_014550.1 3051135 3051743 R sarcosine oxidase catalyzes the oxidative demethylation of sarcosine and forms equimolar amounts of formaldehyde, glycine and hydrogen peroxide; heterotetrameric sarcosine oxidase subunit gamma complement(3051135..3051743) Arthrobacter arilaitensis Re117 9794258 YP_003917900.1 CDS soxA NC_014550.1 3051736 3054633 R sarcosine oxidase catalyzes the oxidative demethylation of sarcosine and forms equimolar amounts of formaldehyde, glycine and hydrogen peroxide; heterotetrameric sarcosine oxidase subunit alpha complement(3051736..3054633) Arthrobacter arilaitensis Re117 9794403 YP_003917901.1 CDS soxD NC_014550.1 3054630 3054929 R sarcosine oxidase catalyzes the oxidative demethylation of sarcosine and forms equimolar amounts of formaldehyde, glycine and hydrogen peroxide; heterotetrameric sarcosine oxidase subunit delta complement(3054630..3054929) Arthrobacter arilaitensis Re117 9794400 YP_003917902.1 CDS soxB NC_014550.1 3054941 3056158 R sarcosine oxidase catalyzes the oxidative demethylation of sarcosine and forms equimolar amounts of formaldehyde, glycine and hydrogen peroxide; heterotetrameric sarcosine oxidase subunit beta complement(3054941..3056158) Arthrobacter arilaitensis Re117 9794402 YP_003917903.1 CDS glyA NC_014550.1 3056161 3057477 R catalyzes the transfer of the hydroxymethyl group of serine to tetrahydrofolate to form 5,10- methylenetetrahydrofolate and glycine. Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine; glycine hydroxymethyltransferase complement(3056161..3057477) Arthrobacter arilaitensis Re117 9794401 YP_003917904.1 CDS AARI_27220 NC_014550.1 3057629 3058288 D identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator 3057629..3058288 Arthrobacter arilaitensis Re117 9793927 YP_003917905.1 CDS AARI_27230 NC_014550.1 3058700 3059494 D creatininase catalyses the formation of creatine from creatinine; creatininase 3058700..3059494 Arthrobacter arilaitensis Re117 9795958 YP_003917906.1 CDS opuD NC_014550.1 3059538 3061241 D identified by similarity to protein SP:P54417 (Bacillus subtilis). betaine/carnitine/choline transporter (BCCT) family, glycine betaine:H+ symporter (TC 2.A.15.1. 1). High-affinity uptake of glycine betaine; glycine betaine transporter 3059538..3061241 Arthrobacter arilaitensis Re117 9795959 YP_003917907.1 CDS AARI_27250 NC_014550.1 3061538 3062791 D hydrolyzes creatine to sarcosine and urea; creatinase 3061538..3062791 Arthrobacter arilaitensis Re117 9794159 YP_003917908.1 CDS proP NC_014550.1 3062985 3064325 D identified by similarity to protein SP:P0C0L7 (Escherichia coli). Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. Metabolite:H+ symporter (MHS) family, (Poline/glycine-betaine):(H+/Na+) symporter (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1- carboxymethyl-pyridinium) (subject to osmotic activation) (TC 2.A.1.6.4); proline/betaine transporter 3062985..3064325 Arthrobacter arilaitensis Re117 9795960 YP_003917909.1 CDS AARI_27270 NC_014550.1 3064357 3065130 D identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 3064357..3065130 Arthrobacter arilaitensis Re117 9794228 YP_003917910.1 CDS AARI_27280 NC_014550.1 3065133 3065549 D presence of one conserved barrel domain of the cupin superfamily (PF07883); hypothetical protein 3065133..3065549 Arthrobacter arilaitensis Re117 9795961 YP_003917911.1 CDS AARI_27290 NC_014550.1 3065606 3066193 D identified by match to PF03358. FMN reductase reductase catalyses the following reaction: NAD(P)H + FMN = NAD(P)(+) + FMNH(2); FMN reductase 3065606..3066193 Arthrobacter arilaitensis Re117 9795962 YP_003917912.1 CDS AARI_27300 NC_014550.1 3066439 3067263 R match to PF04434: SWIM zinc finger. SWIM is thought to be a versatile domain that can interact with DNA or proteins in different contexts; zinc finger domain-containing protein complement(3066439..3067263) Arthrobacter arilaitensis Re117 9795963 YP_003917913.1 CDS AARI_27310 NC_014550.1 3067256 3070405 R possible DNA or RNA helicase; ATP-dependent helicase complement(3067256..3070405) Arthrobacter arilaitensis Re117 9795964 YP_003917914.1 CDS AARI_27320 NC_014550.1 3070873 3071298 D identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein 3070873..3071298 Arthrobacter arilaitensis Re117 9793644 YP_003917915.1 CDS AARI_27330 NC_014550.1 3071309 3072535 R drug:H+ antiporter-1 (12 Spanner) (DHA1) family transporter (TC 2.A.1.2.z). Match to PR01035 (Tetracycline resistance protein signature); multidrug efflux permease complement(3071309..3072535) Arthrobacter arilaitensis Re117 9795966 YP_003917916.1 CDS AARI_27340 NC_014550.1 3072681 3073622 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3072681..3073622 Arthrobacter arilaitensis Re117 9795967 YP_003917917.1 CDS AARI_27350 NC_014550.1 3073619 3074293 R identified by match to PF03171. This family contains members of the 2-oxoglutarate (2OG) and Fe(II)- dependent oxygenase superfamily; 2OG-Fe(II) oxygenase superfamily protein complement(3073619..3074293) Arthrobacter arilaitensis Re117 9795968 YP_003917918.1 CDS cobA NC_014550.1 3074585 3075604 D catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2 (dihydrosirohydrochlorin): (1) S- adenosyl-L-methionine + uroporphyrinogen III <=> S- adenosyl-L-homocysteine + precorrin-1, (2) S-adenosyl-L- methionine + precorrin-1 <=> S-adenosyl-L-homocysteine + precorrin-2; uroporphyrinogen-III C-methyltransferase 3074585..3075604 Arthrobacter arilaitensis Re117 9795969 YP_003917919.1 CDS hemD NC_014550.1 3075604 3076704 D uroporphyrinogen-III synthase catalyses the following reaction: hydroxymethylbilane <=> uroporphyrinogen III + H(2)O. Possible fusion with a response regulator domain protein; uroporphyrinogen-III synthase 3075604..3076704 Arthrobacter arilaitensis Re117 9793752 YP_003917920.1 CDS AARI_27380 NC_014550.1 3076751 3077659 D fructokinase catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into glucose-6-phosphate; fructokinase 3076751..3077659 Arthrobacter arilaitensis Re117 9793952 YP_003917921.1 CDS AARI_27390 NC_014550.1 3077980 3078753 D identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 3077980..3078753 Arthrobacter arilaitensis Re117 9795970 YP_003917922.1 CDS AARI_27400 NC_014550.1 3078765 3079796 R match to protein domain PF01261: xylose isomerase- like TIM barrel . This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC.1.21. 2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins; xylose isomerase-like protein complement(3078765..3079796) Arthrobacter arilaitensis Re117 9795971 YP_003917923.1 CDS AARI_27410 NC_014550.1 3079789 3080895 R identified by match to PF01408 (oxidoreductase family, NAD-binding Rossmann fold) and PF02894 (oxidoreductase family, C-terminal alpha/beta domain); oxidoreductase domain-containing protein complement(3079789..3080895) Arthrobacter arilaitensis Re117 9795972 YP_003917924.1 CDS AARI_27430 NC_014550.1 3081198 3082310 R identified by match to PF01408 (oxidoreductase family, NAD-binding Rossmann fold); oxidoreductase domain-containing protein complement(3081198..3082310) Arthrobacter arilaitensis Re117 9795974 YP_003917925.1 CDS AARI_27440 NC_014550.1 3082316 3083056 R match to protein domain PF01261: xylose isomerase- like TIM barrel. This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC.1.21. 2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins; xylose isomerase-like protein complement(3082316..3083056) Arthrobacter arilaitensis Re117 9795975 YP_003917926.1 CDS AARI_27450 NC_014550.1 3083215 3084429 D identified by match to PF00480: ROK family; transcriptional regulator 3083215..3084429 Arthrobacter arilaitensis Re117 9795976 YP_003917927.1 CDS hutU NC_014550.1 3084560 3086236 D catalyzes the second step in the degradation of histidine, the hydration of urocanate into imidazolonepropionate; urocanate hydratase 3084560..3086236 Arthrobacter arilaitensis Re117 9795977 YP_003917928.1 CDS AARI_27470 NC_014550.1 3086316 3086825 R DPS (DNA Protecting protein under Starved conditions) domain is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. Some DPS proteins nonspecifically bind DNA, protecting it from cleavage caused by reactive oxygen species such as the hydroxyl radicals produced during oxidation of Fe(II) by hydrogen peroxide. These proteins assemble into dodecameric structures, some form DPS-DNA co-crystalline complexes, and possess iron and H2O2 detoxification capabilities. Expression of DPS is induced by oxidative or nutritional stress, including metal ion starvation; DPS family protein complement(3086316..3086825) Arthrobacter arilaitensis Re117 9793994 YP_003917929.1 CDS AARI_27480 NC_014550.1 3087295 3087525 D hypothetical protein 3087295..3087525 Arthrobacter arilaitensis Re117 9795978 YP_003917930.1 CDS AARI_27490 NC_014550.1 3087902 3088516 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.991) with cleavage site probability 0.786 between position 45 and 46; hypothetical protein 3087902..3088516 Arthrobacter arilaitensis Re117 9795979 YP_003917931.1 CDS hutH NC_014550.1 3088698 3090239 D catalyzes the first step in histidine degradation, the removal of an ammonia group from histidine to produce urocanic acid; histidine ammonia-lyase 3088698..3090239 Arthrobacter arilaitensis Re117 9795980 YP_003917932.1 CDS panD NC_014550.1 3090349 3090771 D step in the major route of beta-alanine production for pantothenate biosynthesis in bacteria; aspartate 1-decarboxylase 3090349..3090771 Arthrobacter arilaitensis Re117 9793991 YP_003917933.1 CDS uvrA NC_014550.1 3090780 3093236 R excinuclease ABC catalyses nucleotide excision repair in a multi-step process; excinuclease ABC subunit A complement(3090780..3093236) Arthrobacter arilaitensis Re117 9794175 YP_003917934.1 CDS AARI_27530 NC_014550.1 3093291 3093659 R hypothetical protein complement(3093291..3093659) Arthrobacter arilaitensis Re117 9794497 YP_003917935.1 CDS AARI_27540 NC_014550.1 3093830 3094312 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3093830..3094312 Arthrobacter arilaitensis Re117 9795981 YP_003917936.1 CDS AARI_27550 NC_014550.1 3094324 3095124 R hypothetical protein complement(3094324..3095124) Arthrobacter arilaitensis Re117 9795982 YP_003917937.1 CDS AARI_27560 NC_014550.1 3095267 3095650 R TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, permease (IM), MOS-family (monosaccharides: pentoses and hexoses), ribose import; ribose ABC transporter inner membrane subunit complement(3095267..3095650) Arthrobacter arilaitensis Re117 9795983 YP_003917938.1 CDS rbsK NC_014550.1 3095686 3096588 R catalyses the phosphorylation of ribose to ribose-5- phosphate. 2-deoxy-D-ribose can also act as acceptor; ribokinase complement(3095686..3096588) Arthrobacter arilaitensis Re117 9795984 YP_003917939.1 CDS AARI_27600 NC_014550.1 3097696 3098730 R match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator complement(3097696..3098730) Arthrobacter arilaitensis Re117 9795986 YP_003917940.1 CDS AARI_27610 NC_014550.1 3098993 3099670 D identified by match to PF01325, PF02742 and PF04023. The diphtheria toxin repressor protein (DTXR) is a member of this group. In Corynebacterium diphtheriae where it has been studied in some detail this protein acts as an iron-binding repressor of dipheteria toxin gene expression and may serve as a global regulator of gene expression. The N-terminus may be involved in iron binding and may associate with the Tox operator. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation; metal-dependent transcriptional regulator 3098993..3099670 Arthrobacter arilaitensis Re117 9795987 YP_003917941.1 CDS AARI_27620 NC_014550.1 3099870 3100832 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.312 between position 36 and 37; hypothetical protein 3099870..3100832 Arthrobacter arilaitensis Re117 9795988 YP_003917942.1 CDS mntB NC_014550.1 3100890 3101765 R TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, permease (IM), MET-family, manganese uptake. Identified by similarity to protein SP:Q55282 (Synechocystis sp.); manganese ABC transporter inner membrane subunit MntB complement(3100890..3101765) Arthrobacter arilaitensis Re117 9795989 YP_003917943.1 CDS mntA NC_014550.1 3101762 3102517 R TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, ATP- binding protein (ABC), MET-family, manganese uptake. Identified by similarity to protein SP:Q55281 (Synechocystis sp.); manganese ABC transporter ATP-binding protein MntA complement(3101762..3102517) Arthrobacter arilaitensis Re117 9794092 YP_003917944.1 CDS mntC NC_014550.1 3102514 3103455 R TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, binding protein (BP), MET-family, manganese uptake. Identified by similarity to protein SP:Q55280 (Synechocystis sp.); manganese ABC transporter substrate-binding protein MntC complement(3102514..3103455) Arthrobacter arilaitensis Re117 9794091 YP_003917945.1 CDS hutG NC_014550.1 3103588 3104544 R hydrolyzes N-formimino-glutamate into glutamate and formamide; formimidoylglutamase complement(3103588..3104544) Arthrobacter arilaitensis Re117 9794093 YP_003917946.1 CDS AARI_27670 NC_014550.1 3104632 3105285 R hypothetical protein complement(3104632..3105285) Arthrobacter arilaitensis Re117 9793990 YP_003917947.1 CDS AARI_27700 NC_014550.1 3106512 3106859 R hypothetical protein complement(3106512..3106859) Arthrobacter arilaitensis Re117 9795992 YP_003917948.1 CDS AARI_27710 NC_014550.1 3107106 3107792 D identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 3107106..3107792 Arthrobacter arilaitensis Re117 9795993 YP_003917949.1 CDS AARI_27730 NC_014550.1 3108604 3109413 R 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3108604..3109413) Arthrobacter arilaitensis Re117 9795995 YP_003917950.1 CDS AARI_27740 NC_014550.1 3109915 3110706 D identified by match to PF00376 and PF09278. Members of the family include the mercuric resistance operon regulatory protein merR; Bacillus subtilis bltR and bmrR; Bacillus glnR; Streptomyces coelicolor hspR; Bradyrhizobium japonicum nolA; Escherichia coli superoxide response regulator soxR; and Streptomyces lividans transcriptional activator tipA; MerR family transcriptional regulator 3109915..3110706 Arthrobacter arilaitensis Re117 9795996 YP_003917951.1 CDS AARI_27750 NC_014550.1 3110725 3110907 R match to PF00376: MerR family regulatory protein; DNA-binding protein complement(3110725..3110907) Arthrobacter arilaitensis Re117 9795997 YP_003917952.1 CDS AARI_27760 NC_014550.1 3111158 3111640 D identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator 3111158..3111640 Arthrobacter arilaitensis Re117 9795998 YP_003917953.1 CDS AARI_27770 NC_014550.1 3111717 3112778 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(3111717..3112778) Arthrobacter arilaitensis Re117 9795999 YP_003917954.1 CDS AARI_27780 NC_014550.1 3112925 3113329 R identified by match to protein family PF01451. Protein tyrosine (pTyr) phosphorylation is a common post- translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; EC:3.1.3.48) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation. Low molecular weight (LMW) protein-tyrosine phosphatases (or acid phosphatase) act on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; low molecular weight protein-tyrosine-phosphatase complement(3112925..3113329) Arthrobacter arilaitensis Re117 9796000 YP_003917955.1 CDS AARI_27790 NC_014550.1 3113484 3115007 R amino acid-polyamine-organocation (APC) superfamily (TC 2.A.3.y.z); amino acid transporter complement(3113484..3115007) Arthrobacter arilaitensis Re117 9796001 YP_003917956.1 CDS AARI_27800 NC_014550.1 3115159 3116031 R identified by match to PF00582: universal stress protein family. The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general stress endurance activity; universal stress protein complement(3115159..3116031) Arthrobacter arilaitensis Re117 9796002 YP_003917957.1 CDS puo NC_014550.1 3116035 3117462 R catalyses the following reaction: putrescine + O(2) + H(2)O <=> 4-aminobutanal + NH(3) + H(2)O(2); putrescine oxidase complement(3116035..3117462) Arthrobacter arilaitensis Re117 9796003 YP_003917958.1 CDS AARI_27820 NC_014550.1 3117569 3118216 D identified by match to PF00440: bacterial regulatory proteins, tetR family; TetR family transcriptional regulator 3117569..3118216 Arthrobacter arilaitensis Re117 9794243 YP_003917959.1 CDS AARI_27830 NC_014550.1 3118213 3118443 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3118213..3118443 Arthrobacter arilaitensis Re117 9796004 YP_003917960.1 CDS AARI_27840 NC_014550.1 3118440 3118628 R hypothetical protein complement(3118440..3118628) Arthrobacter arilaitensis Re117 9796005 YP_003917961.1 CDS AARI_27850 NC_014550.1 3118790 3119161 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(3118790..3119161) Arthrobacter arilaitensis Re117 9796006 YP_003917962.1 CDS AARI_27860 NC_014550.1 3119516 3119761 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(3119516..3119761) Arthrobacter arilaitensis Re117 9796007 YP_003917963.1 CDS AARI_27870 NC_014550.1 3119961 3120449 R identified by match to protein family PF01037; AsnC/Lrp family transcriptional regulator complement(3119961..3120449) Arthrobacter arilaitensis Re117 9796008 YP_003917964.1 CDS AARI_27880 NC_014550.1 3120446 3121015 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3120446..3121015) Arthrobacter arilaitensis Re117 9796009 YP_003917965.1 CDS AARI_27890 NC_014550.1 3121018 3122274 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(3121018..3122274) Arthrobacter arilaitensis Re117 9796010 YP_003917966.1 CDS AARI_27900 NC_014550.1 3122282 3123415 R 3-phenylpropionate dioxygenase converts 3- phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5- cyclohexadiene-1,2-diol (PP-dihydrodiol). Involved in the catabolism of 3-phenylpropionic acid; 3-phenylpropionate dioxygenase ferredoxin reductase subunit complement(3122282..3123415) Arthrobacter arilaitensis Re117 9796011 YP_003917967.1 CDS hcaC NC_014550.1 3123416 3123733 R identified by similarity to SP:P0ABW0. Part of multicomponent 3-phenylpropionate dioxygenase, that converts 3-phenylpropionic acid (PP) into cis-3-(3- carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP- dihydrodiol). Involved in the catabolism of 3- phenylpropionic acid; 3-phenylpropionate dioxygenase ferredoxin subunit complement(3123416..3123733) Arthrobacter arilaitensis Re117 9796012 YP_003917968.1 CDS AARI_27920 NC_014550.1 3123829 3124758 R match to PF01869: BadF/BadG/BcrA/BcrD ATPase family. This family includes the BadF and BadG proteins that are two subunits of Benzoyl-CoA reductase, that may be involved in ATP hydrolysis. The family also includes an activase subunit from the enzyme 2-hydroxyglutaryl-CoA dehydratase; ATPase domain-containing protein complement(3123829..3124758) Arthrobacter arilaitensis Re117 9793947 YP_003917969.1 CDS AARI_27930 NC_014550.1 3125365 3127314 D identified by match to PF00082. Subtilases are a family of serine proteases. The vast majority of the family are endopeptidases. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.991 between position 34 and 35; subtilase 3125365..3127314 Arthrobacter arilaitensis Re117 9796013 YP_003917970.1 CDS AARI_27940 NC_014550.1 3127413 3129203 R match to protein family PF02652. Lactate Permease (LctP) Family (TC 2.A.14.y.z). Members of this family are involved in the uptake of L-lactate, D-lactate and glycolate; lactate permease complement(3127413..3129203) Arthrobacter arilaitensis Re117 9796014 YP_003917971.1 CDS AARI_27950 NC_014550.1 3129569 3130366 R identified by match to protein family PF02900. Dioxygenases catalyse the incorporation of both atoms of molecular oxygen into substrates using a variety of reaction mechanisms. Cleavage of aromatic rings is one of the most important functions of dioxygenases, which play key roles in the degradation of aromatic compounds; aromatic ring-opening dioxygenase catalytic subunit complement(3129569..3130366) Arthrobacter arilaitensis Re117 9796015 YP_003917972.1 CDS AARI_27960 NC_014550.1 3130869 3131312 D identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator 3130869..3131312 Arthrobacter arilaitensis Re117 9796016 YP_003917973.1 CDS AARI_27970 NC_014550.1 3131378 3134593 R possible DNA or RNA helicase; ATP-dependent helicase complement(3131378..3134593) Arthrobacter arilaitensis Re117 9796017 YP_003917974.1 CDS AARI_27980 NC_014550.1 3134885 3135436 D identified by match to protein family PF02566: OsmC, OsmC-like protein. Osmotically inducible protein C (OsmC) is a stress-induced protein found in Escherichia coli. This family also contains an organic hydroperoxide detoxification protein that has a novel pattern of oxidative stress regulation; OsmC-like protein 3134885..3135436 Arthrobacter arilaitensis Re117 9796018 YP_003917975.1 CDS idnD NC_014550.1 3135518 3136546 R L-idonate 5-dehydrogenase catalyzes the NADH/NADPH- dependent oxidation of L-idonate to 5-ketogluconate. It is involved in L-idonic acid degradation; L-idonate 5-dehydrogenase complement(3135518..3136546) Arthrobacter arilaitensis Re117 9796019 YP_003917976.1 CDS idnO NC_014550.1 3136560 3137330 R catalyzes a reversible reduction of 5-ketoglutanate to form D-gluconate; gluconate 5-dehydrogenase complement(3136560..3137330) Arthrobacter arilaitensis Re117 9793999 YP_003917977.1 CDS AARI_28010 NC_014550.1 3137502 3138209 R identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator complement(3137502..3138209) Arthrobacter arilaitensis Re117 9794000 YP_003917978.1 CDS AARI_28020 NC_014550.1 3138234 3139910 R match to protein family PF02652. Lactate Permease (LctP) Family (TC 2.A.14.y.z). Members of this family are involved in the uptake of L-lactate, D-lactate and glycolate; lactate permease complement(3138234..3139910) Arthrobacter arilaitensis Re117 9796020 YP_003917979.1 CDS AARI_28030 NC_014550.1 3140057 3140821 D identified by match to PF02754. This domain is usually found in two copies per protein. It contains up to four conserved cysteines. The group includes proteins characterised as: heterodisulphide reductase, subunit B (HrdB); succinate dehydrogenase, subunit C (SdhC ); Fe-S oxidoreductase; glycerol-3-phosphate dehydrogenase subunit C (Anaerobic GlpC, ); and glycolate oxidase iron-sulfur subunit (GlcF); cysteine-rich domain-containing protein 3140057..3140821 Arthrobacter arilaitensis Re117 9796021 YP_003917980.1 CDS AARI_28040 NC_014550.1 3140839 3142290 D identified by match to protein family TIGR00273; iron-sulfur cluster binding protein 3140839..3142290 Arthrobacter arilaitensis Re117 9796022 YP_003917981.1 CDS AARI_28050 NC_014550.1 3142287 3142919 D hypothetical protein 3142287..3142919 Arthrobacter arilaitensis Re117 9796023 YP_003917982.1 CDS AARI_28060 NC_014550.1 3143119 3144297 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter 3143119..3144297 Arthrobacter arilaitensis Re117 9796024 YP_003917983.1 CDS AARI_28070 NC_014550.1 3144423 3144869 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3144423..3144869 Arthrobacter arilaitensis Re117 9796025 YP_003917984.1 CDS AARI_28080 NC_014550.1 3145008 3145550 R identified by match to protein family PF04264. This entry represents the lipid-binding protein YceI from Escherichia coli and the polyisoprenoid-binding protein TTHA0802 from Thermus thermophilus. The crystal structures of Yce1 and TTHA0802 suggest that this family of proteins plays an important role in isoprenoid quinone metabolism and/or transport and/or storage; YceI family protein complement(3145008..3145550) Arthrobacter arilaitensis Re117 9796026 YP_003917985.1 CDS AARI_28090 NC_014550.1 3145770 3145928 D hypothetical protein 3145770..3145928 Arthrobacter arilaitensis Re117 9796027 YP_003917986.1 CDS AARI_28100 NC_014550.1 3146081 3147058 R TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, binding protein (BP), OTCN-family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L-proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter substrate-binding protein complement(3146081..3147058) Arthrobacter arilaitensis Re117 9796028 YP_003917987.1 CDS AARI_28110 NC_014550.1 3147055 3147783 R TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, permease (IM), OTCN- family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L- proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter inner membrane subunit complement(3147055..3147783) Arthrobacter arilaitensis Re117 9796110 YP_003917988.1 CDS AARI_28120 NC_014550.1 3147780 3149042 R TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OTCN-family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L-proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter ATP-binding subunit complement(3147780..3149042) Arthrobacter arilaitensis Re117 9796111 YP_003917989.1 CDS AARI_28130 NC_014550.1 3149035 3149676 R TCDB: ATP-binding cassette (ABC) superfamily, quaternary amine uptake transporter (QAT) family (TC 3.A.1. 12.z). ABCISSE: ABC transporter, permease (IM), OTCN- family (osmoprotectants, taurine, cyanate and nitrate). Part of an uptake system of osmoprotrectants such as glycine betaine, carnitine, choline, proline betaine and L- proline; osmoprotectant (glycine betaine/carnitine/choline/L-proline) ABC transporter inner membrane subunit complement(3149035..3149676) Arthrobacter arilaitensis Re117 9796112 YP_003917990.1 CDS AARI_28140 NC_014550.1 3149896 3150753 D fumarylacetoacetate hydrolase family protein 3149896..3150753 Arthrobacter arilaitensis Re117 9796113 YP_003917991.1 CDS AARI_28150 NC_014550.1 3150864 3151925 D match to PF07683: Cobalamin synthesis protein cobW C-terminal domain; CobW domain-containing protein 3150864..3151925 Arthrobacter arilaitensis Re117 9796114 YP_003917992.1 CDS AARI_28160 NC_014550.1 3152265 3153755 D Alanine or Glycine:Cation Symporter (AGCS) Family (TC 2.A.25.y.z). Members of the AGCS family transport alanine and/or glycine in symport with Na+ and or H+; alanine transporter 3152265..3153755 Arthrobacter arilaitensis Re117 9796115 YP_003917993.1 CDS AARI_28170 NC_014550.1 3153842 3154687 R citrate lyase catalyses the formation of acetate and oxaloacetate from citrate; citrate lyase beta subunit complement(3153842..3154687) Arthrobacter arilaitensis Re117 9796116 YP_003917994.1 CDS cycA NC_014550.1 3155301 3156782 D amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family, D- Serine/D-alanine/glycine:H+ symporter (TC 2.A.3.1.7). Identified by similarity to protein SP:P0AAE0 (Escherichia coli); D-serine/D-alanine/glycine transporter 3155301..3156782 Arthrobacter arilaitensis Re117 9796117 YP_003917995.1 CDS AARI_28190 NC_014550.1 3156807 3157235 R hypothetical protein complement(3156807..3157235) Arthrobacter arilaitensis Re117 9793769 YP_003917996.1 CDS AARI_28200 NC_014550.1 3157267 3157731 R hypothetical protein complement(3157267..3157731) Arthrobacter arilaitensis Re117 9796118 YP_003917997.1 CDS AARI_28210 NC_014550.1 3157905 3159080 R catalyzes the oxidative decarboxylation of malate into pyruvate. Uses preferentially NAD and has the ability to decarboxylate oxaloacetate; malate dehydrogenase (oxaloacetate-decarboxylating) complement(3157905..3159080) Arthrobacter arilaitensis Re117 9796119 YP_003917998.1 CDS AARI_28220 NC_014550.1 3159462 3159851 D match to PF00376: MerR family regulatory protein; DNA-binding protein 3159462..3159851 Arthrobacter arilaitensis Re117 9796120 YP_003917999.1 CDS AARI_28230 NC_014550.1 3159848 3160705 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3159848..3160705 Arthrobacter arilaitensis Re117 9796121 YP_003918000.1 CDS AARI_28240 NC_014550.1 3160859 3162094 D identified by match to PF00155: aminotransferase class I and II; aminotransferase 3160859..3162094 Arthrobacter arilaitensis Re117 9796122 YP_003918001.1 CDS AARI_28250 NC_014550.1 3162191 3163123 R identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator complement(3162191..3163123) Arthrobacter arilaitensis Re117 9796123 YP_003918002.1 CDS AARI_28260 NC_014550.1 3163196 3164254 D 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3163196..3164254 Arthrobacter arilaitensis Re117 9796124 YP_003918003.1 CDS bdhA NC_014550.1 3164292 3165071 R 3-hydroxybutyrate dehydrogenase catalyzes the following reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH. It may be involved in the catabolism of the intracellular carbon storage compound poly-3- hydroxybutyrate; 3-hydroxybutyrate dehydrogenase complement(3164292..3165071) Arthrobacter arilaitensis Re117 9796125 YP_003918004.1 CDS AARI_28280 NC_014550.1 3165308 3166012 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 3165308..3166012 Arthrobacter arilaitensis Re117 9793710 YP_003918005.1 CDS AARI_28290 NC_014550.1 3166024 3167160 R possibly involved in the metabolism of lipids. Match to protein domains PF08028, PF02771 and PF02770. Acyl-CoA dehydrogenases catalyze the alpha,beta- dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase complement(3166024..3167160) Arthrobacter arilaitensis Re117 9796126 YP_003918006.1 CDS AARI_28300 NC_014550.1 3167281 3167790 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 3167281..3167790 Arthrobacter arilaitensis Re117 9796127 YP_003918007.1 CDS AARI_28310 NC_014550.1 3167787 3168155 R identified by match to PF01638: HxlR-like helix- turn-helix; transcriptional regulator complement(3167787..3168155) Arthrobacter arilaitensis Re117 9796128 YP_003918008.1 CDS AARI_28320 NC_014550.1 3168241 3168849 D hypothetical protein 3168241..3168849 Arthrobacter arilaitensis Re117 9796129 YP_003918009.1 CDS AARI_28330 NC_014550.1 3168981 3170645 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein 3168981..3170645 Arthrobacter arilaitensis Re117 9796130 YP_003918010.1 CDS AARI_28340 NC_014550.1 3170652 3171584 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 3170652..3171584 Arthrobacter arilaitensis Re117 9796131 YP_003918011.1 CDS AARI_28350 NC_014550.1 3171581 3172378 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 3171581..3172378 Arthrobacter arilaitensis Re117 9796132 YP_003918012.1 CDS AARI_28360 NC_014550.1 3172375 3173970 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, fused ATP-binding protein (ABC2), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit 3172375..3173970 Arthrobacter arilaitensis Re117 9796133 YP_003918013.1 CDS AARI_28370 NC_014550.1 3174074 3174862 R TCDB: ATP-binding cassette (ABC) superfamily (TC 3. A.1.y.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OTCN-family (osmoprotectants, taurine, cyanate and nitrate); ABC transporter ATP-binding subunit complement(3174074..3174862) Arthrobacter arilaitensis Re117 9796134 YP_003918014.1 CDS AARI_28430 NC_014550.1 3176557 3178245 R activates fatty acids by binding to coenzyme A. Possibly involved in the synthesis of cellular lipids or their degradation via beta-oxidation; fatty-acid--CoA ligase complement(3176557..3178245) Arthrobacter arilaitensis Re117 9796140 YP_003918015.1 CDS AARI_28440 NC_014550.1 3178317 3180071 D hypothetical protein 3178317..3180071 Arthrobacter arilaitensis Re117 9796141 YP_003918016.1 CDS AARI_28450 NC_014550.1 3180068 3181168 R match to PF01168: Alanine racemase, N-terminal domain; alanine racemase-like protein complement(3180068..3181168) Arthrobacter arilaitensis Re117 9796142 YP_003918017.1 CDS AARI_28460 NC_014550.1 3181278 3182114 R identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator complement(3181278..3182114) Arthrobacter arilaitensis Re117 9796143 YP_003918018.1 CDS AARI_28470 NC_014550.1 3182170 3182625 D hypothetical protein 3182170..3182625 Arthrobacter arilaitensis Re117 9796144 YP_003918019.1 CDS scoA NC_014550.1 3182790 3183494 D oxoacid CoA-transferase catalyses the following reaction: succinyl-CoA + a 3-oxo acid <=> succinate + a 3- oxoacyl-CoA. Acetoacetate or, more slowly, 3- oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptor; 3-oxoacid CoA-transferase subunit A 3182790..3183494 Arthrobacter arilaitensis Re117 9796145 YP_003918020.1 CDS scoB NC_014550.1 3183497 3184147 D 3-oxoacid CoA-transferase catalyses the following reaction: succinyl-CoA + a 3-oxo acid <=> succinate + a 3- oxoacyl-CoA. Acetoacetate or, more slowly, 3- oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptor; 3-oxoacid CoA-transferase subunit B 3183497..3184147 Arthrobacter arilaitensis Re117 9794376 YP_003918021.1 CDS AARI_28500 NC_014550.1 3184144 3185313 D catalyses the following reaction: 2 acetyl-CoA <=> CoA + acetoacetyl-CoA; acetyl-CoA C-acetyltransferase 3184144..3185313 Arthrobacter arilaitensis Re117 9794377 YP_003918022.1 CDS AARI_28510 NC_014550.1 3185551 3188031 D 11 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3185551..3188031 Arthrobacter arilaitensis Re117 9796146 YP_003918023.1 CDS AARI_28520 NC_014550.1 3188129 3188689 R identified by match to protein domain PF00300; phosphoglycerate mutase family protein complement(3188129..3188689) Arthrobacter arilaitensis Re117 9796147 YP_003918024.1 CDS AARI_28530 NC_014550.1 3188754 3189584 R identified by match to PF00149. The metallo- phosphoesterase motif is found in a large number of proteins invoved in phosphorylation. These include Ser/Thr phosphatases, DNA polymerase, exonucleases, and other phosphatases; phosphoesterase complement(3188754..3189584) Arthrobacter arilaitensis Re117 9796148 YP_003918025.1 CDS fabH NC_014550.1 3189832 3190782 D catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; beta-ketoacyl-ACP synthase III 3189832..3190782 Arthrobacter arilaitensis Re117 9796149 YP_003918026.1 CDS AARI_28570 NC_014550.1 3192244 3192681 D hypothetical protein 3192244..3192681 Arthrobacter arilaitensis Re117 9796151 YP_003918027.1 CDS AARI_28580 NC_014550.1 3192819 3193523 D GntR family transcriptional regulator 3192819..3193523 Arthrobacter arilaitensis Re117 9796152 YP_003918028.1 CDS ansA NC_014550.1 3193520 3194515 D catalyses the hydrolysis of L-asparagine to L- aspartate and ammonium; L-asparaginase 3193520..3194515 Arthrobacter arilaitensis Re117 9796153 YP_003918029.1 CDS aspA NC_014550.1 3194560 3195975 D catalyzes the reversible conversion of aspartate to fumarate and ammonia; aspartate ammonia-lyase 3194560..3195975 Arthrobacter arilaitensis Re117 9793666 YP_003918030.1 CDS AARI_28630 NC_014550.1 3197555 3198358 R match to PS51257: prokaryotic membrane lipoprotein lipid attachment site profile; hypothetical protein complement(3197555..3198358) Arthrobacter arilaitensis Re117 9796155 YP_003918031.1 CDS AARI_28640 NC_014550.1 3198564 3200621 D identified by match to protein family PF00326. Prolyl oligopeptidase family consist of a number of evolutionary related peptidases whose catalytic activity seems to be provided by a charge relay system similar to that of the trypsin family of serine proteases, but which evolved by independent convergent evolution; prolyl oligopeptidase family protein 3198564..3200621 Arthrobacter arilaitensis Re117 9796156 YP_003918032.1 CDS AARI_28650 NC_014550.1 3200628 3203162 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.485 between position 41 and 42. 3 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(3200628..3203162) Arthrobacter arilaitensis Re117 9796157 YP_003918033.1 CDS AARI_28660 NC_014550.1 3203174 3204631 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.702 between position 38 and 39. 1 transmembrane helice predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(3203174..3204631) Arthrobacter arilaitensis Re117 9796158 YP_003918034.1 CDS AARI_28670 NC_014550.1 3204691 3205587 R match to protein family TIGR02937. Sigma-70 family; RNA polymerase sigma factor complement(3204691..3205587) Arthrobacter arilaitensis Re117 9796159 YP_003918035.1 CDS AARI_28680 NC_014550.1 3205587 3206027 R hypothetical protein complement(3205587..3206027) Arthrobacter arilaitensis Re117 9796160 YP_003918036.1 CDS AARI_28690 NC_014550.1 3206162 3207577 R possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes; 2-oxoacid dehydrogenase E2 component complement(3206162..3207577) Arthrobacter arilaitensis Re117 9796161 YP_003918037.1 CDS AARI_28700 NC_014550.1 3207599 3208576 R possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes; 2-oxoacid dehydrogenase E1 component subunit beta complement(3207599..3208576) Arthrobacter arilaitensis Re117 9796162 YP_003918038.1 CDS AARI_28710 NC_014550.1 3208577 3209719 R possible component of pyruvate dehydrogenase (EC 2. 3.1.12), branched-chain alpha-ketoacid dehydrogenase (EC 2. 3.1.168) or 2-oxoglutarate dehydrogenase (EC 2.3.1.61) complexes; 2-oxoacid dehydrogenase E1 component subunit alpha complement(3208577..3209719) Arthrobacter arilaitensis Re117 9796163 YP_003918039.1 CDS pat NC_014550.1 3209847 3210956 R may catalyze the transamination reaction in phenylalanine biosynthesis; phenylalanine aminotransferase complement(3209847..3210956) Arthrobacter arilaitensis Re117 9796164 YP_003918040.1 CDS AARI_28730 NC_014550.1 3211039 3211425 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3211039..3211425 Arthrobacter arilaitensis Re117 9794179 YP_003918041.1 CDS AARI_28740 NC_014550.1 3211587 3212936 R hypothetical protein complement(3211587..3212936) Arthrobacter arilaitensis Re117 9796165 YP_003918042.1 CDS AARI_28750 NC_014550.1 3212939 3213211 R hypothetical protein complement(3212939..3213211) Arthrobacter arilaitensis Re117 9796166 YP_003918043.1 CDS purB NC_014550.1 3213351 3214760 D catalyzes the eight step in the de novo biosynthesis of purines, the formation of 5-phosphoribosyl- 5-amino-4-imidazolecarboxamide and fumarate from 1-(5- phosphoribosyl)-4-(N-succino-carboxamide). Also catalyzes the formation of fumarate and AMP from adenylosuccinate; adenylosuccinate lyase 3213351..3214760 Arthrobacter arilaitensis Re117 9796167 YP_003918044.1 CDS AARI_28770 NC_014550.1 3214945 3215709 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(3214945..3215709) Arthrobacter arilaitensis Re117 9794245 YP_003918045.1 CDS xdhC NC_014550.1 3215837 3216655 R identified by match to PF02625. XdhC is believed to be involved in the attachment of molybdenum to Xanthine Dehydrogenase; xanthine dehydrogenase accessory protein XdhC complement(3215837..3216655) Arthrobacter arilaitensis Re117 9796168 YP_003918046.1 CDS xdhB NC_014550.1 3216658 3218991 R xanthine dehydrogenase catalyses the formation of xanthine from hypoxanthine and of urate from xanthine. It is involved in purine degradation; xanthine dehydrogenase, molybdopterin-binding subunit complement(3216658..3218991) Arthrobacter arilaitensis Re117 9794506 YP_003918047.1 CDS xdhA NC_014550.1 3218988 3220493 R xanthine dehydrogenase catalyses the formation of xanthine from hypoxanthine and of urate from xanthine. It is involved in purine degradation; xanthine dehydrogenase, iron-sulfur and FAD-binding subunit complement(3218988..3220493) Arthrobacter arilaitensis Re117 9794505 YP_003918048.1 CDS AARI_28810 NC_014550.1 3220490 3220696 R hypothetical protein complement(3220490..3220696) Arthrobacter arilaitensis Re117 9794504 YP_003918049.1 CDS AARI_28820 NC_014550.1 3220766 3222268 R AzgA family purine transporter (TC 2.A.1.40.z). Possibly involved in transport of compounds such as hypoxanthine, adenine, guanine, guanosine and urate; purine transporter complement(3220766..3222268) Arthrobacter arilaitensis Re117 9796169 YP_003918050.1 CDS AARI_28850 NC_014550.1 3223204 3224613 D Nitrate/Nitrite Porter (NNP) family (TC 2.A.1.8.z); nitrate/nitrite transporter 3223204..3224613 Arthrobacter arilaitensis Re117 9796172 YP_003918051.1 CDS AARI_28860 NC_014550.1 3224615 3226750 D possible flavoprotein that may act as electron donnor in the assimilatory nitrite reductase. EC 1.7.1.4 catalyses the following reaction: ammonium hydroxide + 3 NAD(P)(+) + H(2)O <=> nitrite + 3 NAD(P)H; nitrite reductase (NAD(P)H) subunit 3224615..3226750 Arthrobacter arilaitensis Re117 9796173 YP_003918052.1 CDS AARI_28870 NC_014550.1 3226747 3228237 D the assimilatory nitrite reductase catalyses the following reaction: ammonium hydroxide + 3 NAD(P)(+) + H(2)O <=> nitrite + 3 NAD(P)H; nitrite reductase (NAD(P)H) subunit 3226747..3228237 Arthrobacter arilaitensis Re117 9796174 YP_003918053.1 CDS AARI_28880 NC_014550.1 3228421 3228864 R hypothetical protein complement(3228421..3228864) Arthrobacter arilaitensis Re117 9796175 YP_003918054.1 CDS AARI_28890 NC_014550.1 3229093 3229191 R hypothetical protein complement(3229093..3229191) Arthrobacter arilaitensis Re117 9796176 YP_003918055.1 CDS nirD NC_014550.1 3229188 3229565 R the assimilatory nitrite reductase catalyses the following reaction: ammonium hydroxide + 3 NAD(P)(+) + H(2)O <=> nitrite + 3 NAD(P)H. NirD contains a single Rieske [2Fe-2S] cluster binding domain involved in electron transfer; nitrite reductase (NAD(P)H) small subunit complement(3229188..3229565) Arthrobacter arilaitensis Re117 9796177 YP_003918056.1 CDS nirB NC_014550.1 3229924 3232539 D the assimilatory nitrite reductase catalyses the following reaction: ammonium hydroxide + 3 NAD(P)(+) + H(2)O <=> nitrite + 3 NAD(P)H; nitrite reductase (NAD(P)H) large subunit 3229924..3232539 Arthrobacter arilaitensis Re117 9794142 YP_003918057.1 CDS AARI_28920 NC_014550.1 3232562 3233557 R identified by match to PF00248 family: Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity; aldo-keto reductase family protein complement(3232562..3233557) Arthrobacter arilaitensis Re117 9794141 YP_003918058.1 CDS AARI_28930 NC_014550.1 3233685 3234572 D identified by match to protein family PF01145. The band 7 protein is an integral membrane protein which is thought to regulate cation conductance. A variety of proteins belong to this family; band 7 family protein 3233685..3234572 Arthrobacter arilaitensis Re117 9796178 YP_003918059.1 CDS fdhF NC_014550.1 3236280 3238601 R formate dehydrogenase catalyses the formation of CO(2) and NADH from formate and NAD(+); formate dehydrogenase complement(3236280..3238601) Arthrobacter arilaitensis Re117 9796181 YP_003918060.1 CDS fdhD NC_014550.1 3238659 3239489 R necessary for nitrate inducible formate dehydrogenase activity; formate dehydrogenase family accessory protein FdhD complement(3238659..3239489) Arthrobacter arilaitensis Re117 9793847 YP_003918061.1 CDS AARI_28980 NC_014550.1 3239585 3240424 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 3239585..3240424 Arthrobacter arilaitensis Re117 9793846 YP_003918062.1 CDS AARI_28990 NC_014550.1 3240402 3241172 R identified by match to PF00903: glyoxalase/bleomycin resistance protein/dioxygenase superfamily; glyoxalase family protein complement(3240402..3241172) Arthrobacter arilaitensis Re117 9796182 YP_003918063.1 CDS AARI_29000 NC_014550.1 3241364 3242923 D activates fatty acids by binding to coenzyme A. Possibly involved in the synthesis of cellular lipids or their degradation via beta-oxidation; fatty-acid--CoA ligase 3241364..3242923 Arthrobacter arilaitensis Re117 9796183 YP_003918064.1 CDS AARI_29010 NC_014550.1 3242930 3243724 R match to protein family PF00378. This family contains a diverse set of enzymes including: Enoyl-CoA hydratase, Napthoate synthase, Carnitate racemase, 3- hydoxybutyryl-CoA dehydratase, Dodecanoyl-CoA delta- isomerase; enoyl-CoA hydratase/isomerase family protein complement(3242930..3243724) Arthrobacter arilaitensis Re117 9796184 YP_003918065.1 CDS AARI_29030 NC_014550.1 3244230 3244748 D 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3244230..3244748 Arthrobacter arilaitensis Re117 9796186 YP_003918066.1 CDS AARI_29040 NC_014550.1 3244745 3245350 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(3244745..3245350) Arthrobacter arilaitensis Re117 9796187 YP_003918067.1 CDS AARI_29050 NC_014550.1 3245347 3246501 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 5 transmembrane helices predicted by TMHMM2.0; signal transduction histidine kinase complement(3245347..3246501) Arthrobacter arilaitensis Re117 9796188 YP_003918068.1 CDS AARI_29060 NC_014550.1 3246498 3247253 R TCDB: ATP-binding cassette (ABC) superfamily, drug exporter-1 (DrugE1) family (TC 3.A.1.105.z). ABCISSE: ABC transporter, permease (IM), DRA-family (Drug and Antibiotic resistance), DRR-subfamily (Polyketide drug resistance). The typical organization of DRR systems consists of 1 ABC transporter (ABC) and 1 or 2 permeases (IM). Possible function in drug efflux; ABC drug resistance transporter, inner membrane subunit complement(3246498..3247253) Arthrobacter arilaitensis Re117 9796189 YP_003918069.1 CDS AARI_29070 NC_014550.1 3247250 3248167 R TCDB: ATP-binding cassette (ABC) superfamily, drug exporter-1 (DrugE1) family (TC 3.A.1.105.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), DRA-family (Drug and Antibiotic resistance), DRR-subfamily (Polyketide drug resistance). The typical organization of DRR systems consists of 1 ABC transporter (ABC) and 1 or 2 permeases (IM). Possible function in drug efflux; ABC drug resistance transporter, ATP-binding subunit complement(3247250..3248167) Arthrobacter arilaitensis Re117 9796190 YP_003918070.1 CDS AARI_29080 NC_014550.1 3248485 3249189 D 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3248485..3249189 Arthrobacter arilaitensis Re117 9796272 YP_003918071.1 CDS AARI_29090 NC_014550.1 3249193 3249549 R hypothetical protein complement(3249193..3249549) Arthrobacter arilaitensis Re117 9796273 YP_003918072.1 CDS AARI_29100 NC_014550.1 3249665 3250522 D match to PF00196: Bacterial regulatory proteins, luxR family; DNA binding domain-containing protein 3249665..3250522 Arthrobacter arilaitensis Re117 9796274 YP_003918073.1 CDS AARI_35630 NC_014550.1 3250902 3252098 D transposase of ISAar2, IS110 family 3250902..3252098 Arthrobacter arilaitensis Re117 9796275 YP_003918074.1 CDS AARI_29110 NC_014550.1 3252492 3253040 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.712 between position 26 and 27; hypothetical protein 3252492..3253040 Arthrobacter arilaitensis Re117 9793504 YP_003918075.1 CDS AARI_29120 NC_014550.1 3253049 3253612 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3253049..3253612 Arthrobacter arilaitensis Re117 9796276 YP_003918076.1 CDS AARI_29130 NC_014550.1 3253609 3254241 D match to protein domain TIGR00746: LPXTG-motif cell wall anchor. Surface proteins from Gram-positive cocci are covalently linked to the bacterial cell wall by sortase, a membrane-anchored transpeptidase that cleaves proteins between the threonine and the glycine of a conserved LPxTG motif, with the formation of a thioester between the conserved cysteine of sortase and the threonine carboxyl group. The newly liberated C-terminus of the threonine is transferred via an amide bond exchange to the amino group of the pentaglycine wall crossbridge, thereby tethering the C-terminus end of the surface protein to the bacterial peptidoglycan.The proteins that contain the conserved hexapeptide and hydrophobic anchor are diverse: they include M proteins, IgA and IgG binding proteins, fibronectin-binding proteins, wall-associated proteins, trypsin-resistant surface T protein, protein H precursor, etc. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.628 between position 24 and 25; cell surface protein 3253609..3254241 Arthrobacter arilaitensis Re117 9796277 YP_003918077.1 CDS AARI_29140 NC_014550.1 3254348 3254821 D hypothetical protein 3254348..3254821 Arthrobacter arilaitensis Re117 9796278 YP_003918078.1 CDS AARI_29150 NC_014550.1 3254821 3255381 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3254821..3255381 Arthrobacter arilaitensis Re117 9796279 YP_003918079.1 CDS AARI_29160 NC_014550.1 3255704 3256216 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.487 between position 34 and 35; hypothetical protein 3255704..3256216 Arthrobacter arilaitensis Re117 9796280 YP_003918080.1 CDS AARI_35640 NC_014550.1 3256635 3257942 D transposase of ISAar20, ISL3 family 3256635..3257942 Arthrobacter arilaitensis Re117 9796281 YP_003918081.1 CDS AARI_29170 NC_014550.1 3258008 3259204 R catalyses the following reaction: L-aspartate + 2- oxoglutarate <=> oxaloacetate + L-glutamate; aspartate transaminase complement(3258008..3259204) Arthrobacter arilaitensis Re117 9793505 YP_003918082.1 CDS AARI_29180 NC_014550.1 3259441 3261336 D identified by match to PF00149. The metallo- phosphoesterase motif is found in a large number of proteins invoved in phosphorylation. These include Ser/Thr phosphatases, DNA polymerase, exonucleases, and other phosphatases; phosphoesterase 3259441..3261336 Arthrobacter arilaitensis Re117 9796282 YP_003918083.1 CDS AARI_29190 NC_014550.1 3261379 3262503 R 10 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3261379..3262503) Arthrobacter arilaitensis Re117 9796283 YP_003918084.1 CDS AARI_35650 NC_014550.1 3264844 3266289 D transposase of ISAar22, IS481 family 3264844..3266289 Arthrobacter arilaitensis Re117 9796289 YP_003918085.1 CDS AARI_29250 NC_014550.1 3266435 3267112 D identified by match to PF00702. This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases; haloacid dehalogenase 3266435..3267112 Arthrobacter arilaitensis Re117 9793506 YP_003918086.1 CDS AARI_29260 NC_014550.1 3267202 3267789 D identified by match to PF00702. This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases; haloacid dehalogenase 3267202..3267789 Arthrobacter arilaitensis Re117 9796290 YP_003918087.1 CDS AARI_29270 NC_014550.1 3268150 3268818 R match to PTHR11638: ATP-dependent CLP protease; hypothetical protein complement(3268150..3268818) Arthrobacter arilaitensis Re117 9796291 YP_003918088.1 CDS AARI_29280 NC_014550.1 3269005 3269751 R hypothetical protein complement(3269005..3269751) Arthrobacter arilaitensis Re117 9796292 YP_003918089.1 CDS AARI_29290 NC_014550.1 3269934 3270329 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.726 between position 24 and 25. 2 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 3269934..3270329 Arthrobacter arilaitensis Re117 9796293 YP_003918090.1 CDS AARI_29300 NC_014550.1 3270377 3270919 R identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase complement(3270377..3270919) Arthrobacter arilaitensis Re117 9796294 YP_003918091.1 CDS AARI_35660 NC_014550.1 3271155 3271439 D transposase of ISAar43, IS3 family, IS407 group, orfA 3271155..3271439 Arthrobacter arilaitensis Re117 9796295 YP_003918092.1 CDS AARI_35670 NC_014550.1 3271502 3272305 D transposase of ISAar43, IS3 family, IS407 group, orfB 3271502..3272305 Arthrobacter arilaitensis Re117 9793507 YP_003918093.1 CDS AARI_29310 NC_014550.1 3272641 3273012 R hypothetical protein complement(3272641..3273012) Arthrobacter arilaitensis Re117 9793508 YP_003918094.1 CDS AARI_29320 NC_014550.1 3273044 3273214 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3273044..3273214 Arthrobacter arilaitensis Re117 9796296 YP_003918095.1 CDS AARI_29330 NC_014550.1 3273605 3274549 D lysophospholipase catalyses the release of fatty acids from lysophospholipids; lysophospholipase 3273605..3274549 Arthrobacter arilaitensis Re117 9796297 YP_003918096.1 CDS hsdS NC_014550.1 3275149 3276156 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system specificity subunit complement(3275149..3276156) Arthrobacter arilaitensis Re117 9793509 YP_003918097.1 CDS hsdM NC_014550.1 3276153 3278018 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system modification subunit complement(3276153..3278018) Arthrobacter arilaitensis Re117 9793984 YP_003918098.1 CDS AARI_29360 NC_014550.1 3278077 3278331 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3278077..3278331) Arthrobacter arilaitensis Re117 9793979 YP_003918099.1 CDS AARI_29370 NC_014550.1 3278452 3279060 D identified by match to PF07719. The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins. It mediates protein-protein interactions and the assembly of multiprotein complexes. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding; tetratrico peptide repeat-containing protein 3278452..3279060 Arthrobacter arilaitensis Re117 9796299 YP_003918100.1 CDS AARI_29380 NC_014550.1 3279695 3279997 R hypothetical protein complement(3279695..3279997) Arthrobacter arilaitensis Re117 9796300 YP_003918101.1 CDS AARI_35690 NC_014550.1 3280298 3281575 R transposase of ISAar13, ISL3 family complement(3280298..3281575) Arthrobacter arilaitensis Re117 9796301 YP_003918102.1 CDS AARI_29390 NC_014550.1 3281807 3283747 R TCDB: P-type ATPase (P-ATPase) superfamily (TC 3.A. 3.y.z). Involved in export of cations; cation-transporting ATPase complement(3281807..3283747) Arthrobacter arilaitensis Re117 9793510 YP_003918103.1 CDS AARI_29400 NC_014550.1 3283744 3284112 R identified by match to PF01022: bacterial regulatory protein, ArsR family. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator complement(3283744..3284112) Arthrobacter arilaitensis Re117 9796302 YP_003918104.1 CDS AARI_35700 NC_014550.1 3284272 3285519 R transposase of ISAar13, ISL3 family complement(3284272..3285519) Arthrobacter arilaitensis Re117 9796303 YP_003918105.1 CDS AARI_29410 NC_014550.1 3285685 3286314 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3285685..3286314) Arthrobacter arilaitensis Re117 9793511 YP_003918106.1 CDS AARI_29420 NC_014550.1 3286311 3286649 R identified by match to protein family PF03551; PadR-like family transcriptional regulator complement(3286311..3286649) Arthrobacter arilaitensis Re117 9796304 YP_003918107.1 CDS istA NC_014550.1 3287693 3289156 D transposase of ISAar7, IS21 family, istA 3287693..3289156 Arthrobacter arilaitensis Re117 9793514 YP_003918108.1 CDS istB NC_014550.1 3289153 3289884 D helper of transposition of ISAar7, IS21 family, istB 3289153..3289884 Arthrobacter arilaitensis Re117 9794017 YP_003918109.1 CDS AARI_29430 NC_014550.1 3289881 3290213 D hypothetical protein 3289881..3290213 Arthrobacter arilaitensis Re117 9794020 YP_003918110.1 CDS AARI_35760 NC_014550.1 3290347 3291735 D first part of the IS; transposase of ISAar6, IS256 family 3290347..3291735 Arthrobacter arilaitensis Re117 9796306 YP_003918111.1 CDS AARI_35770 NC_014550.1 3291770 3292840 R transposase of ISAar1, IS1595 family, ISSod11 group complement(3291770..3292840) Arthrobacter arilaitensis Re117 9793515 YP_003918112.1 CDS AARI_29440 NC_014550.1 3293277 3293519 D hypothetical protein 3293277..3293519 Arthrobacter arilaitensis Re117 9793516 YP_003918113.1 CDS AARI_29450 NC_014550.1 3293946 3294248 D hypothetical protein 3293946..3294248 Arthrobacter arilaitensis Re117 9796307 YP_003918114.1 CDS AARI_35780 NC_014550.1 3294339 3295538 R transposase of ISAar5, IS256 family complement(3294339..3295538) Arthrobacter arilaitensis Re117 9796308 YP_003918115.1 CDS AARI_35790 NC_014550.1 3296469 3297776 R transposase of ISAar23, ISL3 family complement(3296469..3297776) Arthrobacter arilaitensis Re117 9793517 YP_003918116.1 CDS AARI_29470 NC_014550.1 3299408 3301168 D identified by match to protein family PF02534. The TraG family are bacterial conjugation proteins. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome although the exact mechanism of action is unknown; TraG family bacterial conjugation protein 3299408..3301168 Arthrobacter arilaitensis Re117 9796309 YP_003918117.1 CDS AARI_29480 NC_014550.1 3301165 3301782 D hypothetical protein 3301165..3301782 Arthrobacter arilaitensis Re117 9796310 YP_003918118.1 CDS AARI_29490 NC_014550.1 3301994 3302563 R hypothetical protein complement(3301994..3302563) Arthrobacter arilaitensis Re117 9796311 YP_003918119.1 CDS AARI_29500 NC_014550.1 3302560 3303141 R identified by match to SM00530: Helix-turn-helix XRE-family like proteins. This is a large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); DNA binding domain-containing protein complement(3302560..3303141) Arthrobacter arilaitensis Re117 9796312 YP_003918120.1 CDS AARI_29520 NC_014550.1 3304202 3304990 D hypothetical protein 3304202..3304990 Arthrobacter arilaitensis Re117 9796314 YP_003918121.1 CDS AARI_29530 NC_014550.1 3305009 3305251 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3305009..3305251 Arthrobacter arilaitensis Re117 9796315 YP_003918122.1 CDS AARI_35800 NC_014550.1 3305456 3306763 D transposase of ISAar23, ISL3 family 3305456..3306763 Arthrobacter arilaitensis Re117 9796316 YP_003918123.1 CDS AARI_29550 NC_014550.1 3309073 3310641 D serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. This protein may be a resolvase (match to PF07508 and PF00239); site-specific recombinase 3309073..3310641 Arthrobacter arilaitensis Re117 9796317 YP_003918124.1 CDS AARI_29560 NC_014550.1 3311857 3312117 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3311857..3312117) Arthrobacter arilaitensis Re117 9796318 YP_003918125.1 CDS AARI_29570 NC_014550.1 3312431 3313129 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.992) with cleavage site probability 0.849 between position 33 and 34; hypothetical protein 3312431..3313129 Arthrobacter arilaitensis Re117 9796319 YP_003918126.1 CDS AARI_29580 NC_014550.1 3313143 3313517 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3313143..3313517) Arthrobacter arilaitensis Re117 9796320 YP_003918127.1 CDS AARI_35810 NC_014550.1 3313846 3314868 R transposase of ISAar25, IS3 family, IS3 group, orfB complement(3313846..3314868) Arthrobacter arilaitensis Re117 9796321 YP_003918128.1 CDS AARI_35820 NC_014550.1 3314763 3315056 R transposase of ISAar25, IS3 family, IS3 group, orfA complement(3314763..3315056) Arthrobacter arilaitensis Re117 9793520 YP_003918129.1 CDS AARI_29610 NC_014550.1 3318675 3319235 R hypothetical protein complement(3318675..3319235) Arthrobacter arilaitensis Re117 9796323 YP_003918130.1 CDS AARI_29630 NC_014550.1 3322632 3323066 D hypothetical protein 3322632..3323066 Arthrobacter arilaitensis Re117 9796325 YP_003918131.1 CDS AARI_29640 NC_014550.1 3323347 3323769 R hypothetical protein complement(3323347..3323769) Arthrobacter arilaitensis Re117 9796326 YP_003918132.1 CDS AARI_29650 NC_014550.1 3325418 3326329 D hypothetical protein 3325418..3326329 Arthrobacter arilaitensis Re117 9796327 YP_003918133.1 CDS AARI_29660 NC_014550.1 3326527 3326781 D hypothetical protein 3326527..3326781 Arthrobacter arilaitensis Re117 9796328 YP_003918134.1 CDS AARI_29670 NC_014550.1 3327323 3328447 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.807) with cleavage site probability 0.454 between position 19 and 20; hypothetical protein 3327323..3328447 Arthrobacter arilaitensis Re117 9796329 YP_003918135.1 CDS AARI_29680 NC_014550.1 3328481 3328900 D hypothetical protein 3328481..3328900 Arthrobacter arilaitensis Re117 9796330 YP_003918136.1 CDS AARI_29700 NC_014550.1 3329677 3329829 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3329677..3329829 Arthrobacter arilaitensis Re117 9796332 YP_003918137.1 CDS istB NC_014550.1 3331942 3332673 D helper of transposition of ISAar7, IS21 family, istB 3331942..3332673 Arthrobacter arilaitensis Re117 9793523 YP_003918138.1 CDS AARI_29710 NC_014550.1 3332670 3333002 D hypothetical protein 3332670..3333002 Arthrobacter arilaitensis Re117 9794021 YP_003918139.1 CDS AARI_29720 NC_014550.1 3333912 3334307 D hypothetical protein 3333912..3334307 Arthrobacter arilaitensis Re117 9796334 YP_003918140.1 CDS AARI_29740 NC_014550.1 3335117 3336238 D hypothetical protein 3335117..3336238 Arthrobacter arilaitensis Re117 9796336 YP_003918141.1 CDS AARI_29750 NC_014550.1 3336245 3336601 D hypothetical protein 3336245..3336601 Arthrobacter arilaitensis Re117 9796337 YP_003918142.1 CDS AARI_29760 NC_014550.1 3336842 3337189 D hypothetical protein 3336842..3337189 Arthrobacter arilaitensis Re117 9796338 YP_003918143.1 CDS AARI_29770 NC_014550.1 3337473 3338141 D match to PF00239 and PF02796. Possibly involved in site-specific recombination of DNA; resolvase 3337473..3338141 Arthrobacter arilaitensis Re117 9796339 YP_003918144.1 CDS AARI_29780 NC_014550.1 3338406 3338693 D hypothetical protein 3338406..3338693 Arthrobacter arilaitensis Re117 9796340 YP_003918145.1 CDS AARI_29790 NC_014550.1 3339036 3339536 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3339036..3339536) Arthrobacter arilaitensis Re117 9796341 YP_003918146.1 CDS AARI_29800 NC_014550.1 3339816 3340859 R hypothetical protein complement(3339816..3340859) Arthrobacter arilaitensis Re117 9796342 YP_003918147.1 CDS AARI_29810 NC_014550.1 3341268 3341765 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.854 between position 36 and 37; hypothetical protein 3341268..3341765 Arthrobacter arilaitensis Re117 9796343 YP_003918148.1 CDS AARI_35860 NC_014550.1 3342128 3342421 D transposase of ISAar25, IS3 family, IS3 group, orfA 3342128..3342421 Arthrobacter arilaitensis Re117 9796344 YP_003918149.1 CDS AARI_29820 NC_014550.1 3342787 3343149 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.750 between position 34 and 35; hypothetical protein complement(3342787..3343149) Arthrobacter arilaitensis Re117 9793525 YP_003918150.1 CDS AARI_29830 NC_014550.1 3343944 3344207 D hypothetical protein 3343944..3344207 Arthrobacter arilaitensis Re117 9793527 YP_003918151.1 CDS AARI_29840 NC_014550.1 3346048 3347190 R 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3346048..3347190) Arthrobacter arilaitensis Re117 9793529 YP_003918152.1 CDS AARI_35920 NC_014550.1 3347456 3348205 R transposase of ISAar3, IS3 family, IS407 group, orfB complement(3347456..3348205) Arthrobacter arilaitensis Re117 9796347 YP_003918153.1 CDS AARI_35930 NC_014550.1 3348325 3348546 R transposase of ISAar3, IS3 family, IS407 group, orfA complement(3348325..3348546) Arthrobacter arilaitensis Re117 9793530 YP_003918154.1 CDS AARI_29850 NC_014550.1 3349156 3349557 D hypothetical protein 3349156..3349557 Arthrobacter arilaitensis Re117 9793531 YP_003918155.1 CDS AARI_35940 NC_014550.1 3350030 3350761 D transposase of ISAar38, IS5 family, IS427 group 3350030..3350761 Arthrobacter arilaitensis Re117 9796348 YP_003918156.1 CDS AARI_29860 NC_014550.1 3350848 3351321 R hypothetical protein complement(3350848..3351321) Arthrobacter arilaitensis Re117 9793532 YP_003918157.1 CDS AARI_29870 NC_014550.1 3351737 3352126 D hypothetical protein 3351737..3352126 Arthrobacter arilaitensis Re117 9796349 YP_003918158.1 CDS AARI_29880 NC_014550.1 3352383 3352976 R match to PF00239 and PF02796. Possibly involved in site-specific recombination of DNA; resolvase complement(3352383..3352976) Arthrobacter arilaitensis Re117 9796350 YP_003918159.1 CDS AARI_35950 NC_014550.1 3353160 3354467 R transposase of ISAar19, ISL3 family complement(3353160..3354467) Arthrobacter arilaitensis Re117 9796351 YP_003918160.1 CDS AARI_29890 NC_014550.1 3354627 3355568 R TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, binding protein (BP), MET-family. This family is comprised of systems involved in the uptake of various metallic cations such as iron, manganese and zinc; iron/manganese/zinc ABC transporter substrate-binding protein complement(3354627..3355568) Arthrobacter arilaitensis Re117 9793533 YP_003918161.1 CDS AARI_29900 NC_014550.1 3355607 3355876 R hypothetical protein complement(3355607..3355876) Arthrobacter arilaitensis Re117 9796352 YP_003918162.1 CDS AARI_29910 NC_014550.1 3356392 3357381 D identified by match to protein family PF0775: Abi- like protein. This family, found in various bacterial species, contains sequences that are similar to the Abi group of proteins, which are involved in bacteriophage resistance mediated by abortive infection in Lactococcus species. The proteins are thought to have helix-turn-helix motifs, found in many DNA-binding proteins, allowing them to perform their function; abortive infection bacteriophage resistance protein 3356392..3357381 Arthrobacter arilaitensis Re117 9796434 YP_003918163.1 CDS AARI_29920 NC_014550.1 3358029 3358604 R identified by match to PF03358. FMN reductase reductase catalyses the following reaction: NAD(P)H + FMN = NAD(P)(+) + FMNH(2); FMN reductase complement(3358029..3358604) Arthrobacter arilaitensis Re117 9796435 YP_003918164.1 CDS nrdF2 NC_014550.1 3358652 3359677 R ribonucleotide reductase catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. It is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues); ribonucleoside-diphosphate reductase subunit beta complement(3358652..3359677) Arthrobacter arilaitensis Re117 9796436 YP_003918165.1 CDS nrdE2 NC_014550.1 3359711 3361876 R catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. It is an oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a small subunit (300 to 400 residues); ribonucleoside-diphosphate reductase subunit alpha complement(3359711..3361876) Arthrobacter arilaitensis Re117 9794147 YP_003918166.1 CDS AARI_29950 NC_014550.1 3361873 3362361 R identified by match to PF03358. FMN reductase reductase catalyses the following reaction: NAD(P)H + FMN = NAD(P)(+) + FMNH(2); FMN reductase complement(3361873..3362361) Arthrobacter arilaitensis Re117 9794145 YP_003918167.1 CDS AARI_29960 NC_014550.1 3362800 3363441 D hypothetical protein 3362800..3363441 Arthrobacter arilaitensis Re117 9796437 YP_003918168.1 CDS AARI_29970 NC_014550.1 3363639 3364052 R hypothetical protein complement(3363639..3364052) Arthrobacter arilaitensis Re117 9796438 YP_003918169.1 CDS AARI_29980 NC_014550.1 3364166 3364558 D identified by match to protein family PF05713: bacterial mobilisation protein (MobC). This family consists of several bacterial MobC-like, mobilisation proteins. MobC proteins belong to the group of relaxases. Together with MobA and MobB they bind to a single cis- active site of a mobilising plasmid, the origin of transfer (oriT) region; mobilisation protein 3364166..3364558 Arthrobacter arilaitensis Re117 9796439 YP_003918170.1 CDS AARI_29990 NC_014550.1 3364555 3366057 D identified by match to protein family PF03432: Relaxase/Mobilisation nuclease domain. Relaxases/mobilisation proteins are required for the horizontal transfer of genetic information contained on plasmids that occurs during bacterial conjugation; mobilisation protein 3364555..3366057 Arthrobacter arilaitensis Re117 9796440 YP_003918171.1 CDS AARI_30000 NC_014550.1 3366084 3366935 D hypothetical protein 3366084..3366935 Arthrobacter arilaitensis Re117 9796441 YP_003918172.1 CDS AARI_30010 NC_014550.1 3366932 3367378 D hypothetical protein 3366932..3367378 Arthrobacter arilaitensis Re117 9796442 YP_003918173.1 CDS AARI_30020 NC_014550.1 3367467 3367661 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3367467..3367661 Arthrobacter arilaitensis Re117 9796443 YP_003918174.1 CDS AARI_30030 NC_014550.1 3367857 3368285 R hypothetical protein complement(3367857..3368285) Arthrobacter arilaitensis Re117 9796444 YP_003918175.1 CDS AARI_30060 NC_014550.1 3376113 3377834 R identified by match to protein family PF02534. The TraG family are bacterial conjugation proteins. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome; TraG family bacterial conjugation protein complement(3376113..3377834) Arthrobacter arilaitensis Re117 9796447 YP_003918176.1 CDS AARI_30070 NC_014550.1 3377834 3379447 R hypothetical protein complement(3377834..3379447) Arthrobacter arilaitensis Re117 9796448 YP_003918177.1 CDS AARI_30080 NC_014550.1 3379447 3380958 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3379447..3380958) Arthrobacter arilaitensis Re117 9796449 YP_003918178.1 CDS AARI_30090 NC_014550.1 3380961 3382574 R 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3380961..3382574) Arthrobacter arilaitensis Re117 9796450 YP_003918179.1 CDS AARI_30100 NC_014550.1 3382584 3383303 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(3382584..3383303) Arthrobacter arilaitensis Re117 9796451 YP_003918180.1 CDS AARI_30110 NC_014550.1 3383341 3383622 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3383341..3383622) Arthrobacter arilaitensis Re117 9796452 YP_003918181.1 CDS AARI_30120 NC_014550.1 3383635 3384252 R hypothetical protein complement(3383635..3384252) Arthrobacter arilaitensis Re117 9796453 YP_003918182.1 CDS AARI_30130 NC_014550.1 3384445 3384663 D hypothetical protein 3384445..3384663 Arthrobacter arilaitensis Re117 9796454 YP_003918183.1 CDS AARI_30140 NC_014550.1 3384692 3386155 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3384692..3386155 Arthrobacter arilaitensis Re117 9796455 YP_003918184.1 CDS AARI_30150 NC_014550.1 3386168 3387298 D identified by match to protein family PF01551. Members of this family are zinc metallopeptidases with a range of specificities. Peptidase family M23 are also endopeptidases; M23 family peptidase 3386168..3387298 Arthrobacter arilaitensis Re117 9796456 YP_003918185.1 CDS AARI_30160 NC_014550.1 3387295 3387858 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.338 between position 48 and 49; hypothetical protein 3387295..3387858 Arthrobacter arilaitensis Re117 9796457 YP_003918186.1 CDS AARI_30170 NC_014550.1 3387907 3389388 D hypothetical protein 3387907..3389388 Arthrobacter arilaitensis Re117 9796458 YP_003918187.1 CDS AARI_30180 NC_014550.1 3389452 3390225 D hypothetical protein 3389452..3390225 Arthrobacter arilaitensis Re117 9796459 YP_003918188.1 CDS AARI_35960 NC_014550.1 3390283 3391593 D transposase of ISAar38, ISL3 family 3390283..3391593 Arthrobacter arilaitensis Re117 9796460 YP_003918189.1 CDS AARI_30190 NC_014550.1 3391617 3392393 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter ATP-binding subunit complement(3391617..3392393) Arthrobacter arilaitensis Re117 9793534 YP_003918190.1 CDS AARI_30200 NC_014550.1 3392390 3393454 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(3392390..3393454) Arthrobacter arilaitensis Re117 9796461 YP_003918191.1 CDS AARI_30210 NC_014550.1 3393444 3394475 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(3393444..3394475) Arthrobacter arilaitensis Re117 9796462 YP_003918192.1 CDS AARI_30220 NC_014550.1 3394490 3395332 R AraC family transcriptional regulator complement(3394490..3395332) Arthrobacter arilaitensis Re117 9796463 YP_003918193.1 CDS AARI_35970 NC_014550.1 3395521 3395820 D transposase of ISAar24, IS3 family, IS3 group, orfA 3395521..3395820 Arthrobacter arilaitensis Re117 9796464 YP_003918194.1 CDS AARI_35980 NC_014550.1 3395817 3396686 D transposase of ISAar24, IS3 family, IS3 group, orfB 3395817..3396686 Arthrobacter arilaitensis Re117 9793535 YP_003918195.1 CDS AARI_36000 NC_014550.1 3397191 3398492 D transposase of ISAar42, ISL3 family 3397191..3398492 Arthrobacter arilaitensis Re117 9793537 YP_003918196.1 CDS AARI_30230 NC_014550.1 3398489 3398632 D hypothetical protein 3398489..3398632 Arthrobacter arilaitensis Re117 9793538 YP_003918197.1 CDS AARI_30240 NC_014550.1 3400227 3400661 D hypothetical protein 3400227..3400661 Arthrobacter arilaitensis Re117 9793540 YP_003918198.1 CDS AARI_30250 NC_014550.1 3400724 3400954 D hypothetical protein 3400724..3400954 Arthrobacter arilaitensis Re117 9796466 YP_003918199.1 CDS AARI_30260 NC_014550.1 3401106 3402533 D hypothetical protein 3401106..3402533 Arthrobacter arilaitensis Re117 9796467 YP_003918200.1 CDS AARI_30270 NC_014550.1 3402707 3402994 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3402707..3402994 Arthrobacter arilaitensis Re117 9796468 YP_003918201.1 CDS AARI_30280 NC_014550.1 3403212 3403595 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3403212..3403595 Arthrobacter arilaitensis Re117 9796469 YP_003918202.1 CDS AARI_30290 NC_014550.1 3403643 3403933 R hypothetical protein complement(3403643..3403933) Arthrobacter arilaitensis Re117 9796470 YP_003918203.1 CDS AARI_30300 NC_014550.1 3404154 3404747 D match to protein family PF01656. chromosome partitioning protein. Similar to uncharacterized plasmidic proteins; ParA family protein 3404154..3404747 Arthrobacter arilaitensis Re117 9796471 YP_003918204.1 CDS AARI_30310 NC_014550.1 3404744 3404980 D hypothetical protein 3404744..3404980 Arthrobacter arilaitensis Re117 9796472 YP_003918205.1 CDS AARI_30320 NC_014550.1 3405441 3405827 D hypothetical protein 3405441..3405827 Arthrobacter arilaitensis Re117 9796473 YP_003918206.1 CDS AARI_30330 NC_014550.1 3405881 3406048 D hypothetical protein 3405881..3406048 Arthrobacter arilaitensis Re117 9796474 YP_003918207.1 CDS nrdH NC_014550.1 3406065 3406289 D electron transport system for the ribonucleotide reductase system nrdEF; glutaredoxin electron transport component NrdH 3406065..3406289 Arthrobacter arilaitensis Re117 9796475 YP_003918208.1 CDS AARI_30350 NC_014550.1 3406645 3407646 D hypothetical protein 3406645..3407646 Arthrobacter arilaitensis Re117 9794149 YP_003918209.1 CDS AARI_30360 NC_014550.1 3407729 3408145 D hypothetical protein 3407729..3408145 Arthrobacter arilaitensis Re117 9796476 YP_003918210.1 CDS AARI_30370 NC_014550.1 3408151 3408384 D hypothetical protein 3408151..3408384 Arthrobacter arilaitensis Re117 9796477 YP_003918211.1 CDS AARI_30380 NC_014550.1 3408586 3408912 D hypothetical protein 3408586..3408912 Arthrobacter arilaitensis Re117 9796478 YP_003918212.1 CDS AARI_30390 NC_014550.1 3409072 3412347 R match to PR00507. Site-specific DNA- methyltransferases specifically methylate the amino group at the C-6 position of adenines in DNA. Such enzymes are found in the bacterial restriction-modification systems. Match to PS00092 pattern: N-6 Adenine-specific DNA methylases signature; site-specific DNA-methyltransferase (adenine specific) complement(3409072..3412347) Arthrobacter arilaitensis Re117 9796479 YP_003918213.1 CDS AARI_30400 NC_014550.1 3412564 3412890 D hypothetical protein 3412564..3412890 Arthrobacter arilaitensis Re117 9796480 YP_003918214.1 CDS AARI_30410 NC_014550.1 3412975 3414378 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3412975..3414378) Arthrobacter arilaitensis Re117 9796481 YP_003918215.1 CDS AARI_30420 NC_014550.1 3414461 3415615 R identified by match to protein family PF04261. This family of dye-decolourising peroxidases lack a typical heme-binding region; Dyp-type peroxidase family protein complement(3414461..3415615) Arthrobacter arilaitensis Re117 9796482 YP_003918216.1 CDS AARI_30430 NC_014550.1 3415663 3416235 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.655 between position 38 and 39; hypothetical protein complement(3415663..3416235) Arthrobacter arilaitensis Re117 9796483 YP_003918217.1 CDS AARI_30440 NC_014550.1 3416642 3417268 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.997) with cleavage site probability 0.878 between position 33 and 34. 4 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(3416642..3417268) Arthrobacter arilaitensis Re117 9796484 YP_003918218.1 CDS AARI_30450 NC_014550.1 3417712 3417981 D hypothetical protein 3417712..3417981 Arthrobacter arilaitensis Re117 9796485 YP_003918219.1 CDS AARI_30460 NC_014550.1 3418020 3418961 D TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, binding protein (BP), MET-family. This family is comprised of systems involved in the uptake of various metallic cations such as iron, manganese and zinc; iron/manganese/zinc ABC transporter substrate-binding protein 3418020..3418961 Arthrobacter arilaitensis Re117 9796486 YP_003918220.1 CDS AARI_30470 NC_014550.1 3418961 3419692 D TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, ATP- binding protein (ABC), MET-family. This family is comprised of systems involved in the uptake of various metallic cations such as iron, manganese and zinc; iron/manganese/zinc ABC transporter ATP-binding subunit 3418961..3419692 Arthrobacter arilaitensis Re117 9796487 YP_003918221.1 CDS AARI_30480 NC_014550.1 3419695 3420582 D TCDB: ATP-binding cassette (ABC) superfamily, Manganese/Zinc/Iron Chelate Uptake Transporter (MZT) Family (TC 3.A.1.15.z). ABCISSE: ABC transporter, permease (IM), MET-family. This family is comprised of systems involved in the uptake of various metallic cations such as iron, manganese and zinc; iron/manganese/zinc ABC transporter inner membrane subunit 3419695..3420582 Arthrobacter arilaitensis Re117 9796488 YP_003918222.1 CDS AARI_30500 NC_014550.1 3421748 3422305 D hypothetical protein 3421748..3422305 Arthrobacter arilaitensis Re117 9796490 YP_003918223.1 CDS AARI_30510 NC_014550.1 3422293 3422754 D hypothetical protein 3422293..3422754 Arthrobacter arilaitensis Re117 9796491 YP_003918224.1 CDS AARI_30520 NC_014550.1 3423063 3423647 D match to PF00239. Possibly involved in site- specific recombination of DNA; resolvase 3423063..3423647 Arthrobacter arilaitensis Re117 9796492 YP_003918225.1 CDS AARI_30530 NC_014550.1 3425162 3425974 D hypothetical protein 3425162..3425974 Arthrobacter arilaitensis Re117 9793541 YP_003918226.1 CDS AARI_36040 NC_014550.1 3426310 3426606 D transposase of ISAar4, IS3 family, IS3 group, orfA 3426310..3426606 Arthrobacter arilaitensis Re117 9796494 YP_003918227.1 CDS AARI_36050 NC_014550.1 3426669 3427496 D transposase of ISAar4, IS3 family, IS3 group, orfB 3426669..3427496 Arthrobacter arilaitensis Re117 9793542 YP_003918228.1 CDS AARI_30540 NC_014550.1 3427593 3428645 D hypothetical protein 3427593..3428645 Arthrobacter arilaitensis Re117 9793543 YP_003918229.1 CDS AARI_30550 NC_014550.1 3428771 3429103 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3428771..3429103) Arthrobacter arilaitensis Re117 9796495 YP_003918230.1 CDS AARI_30560 NC_014550.1 3429418 3430212 D hypothetical protein 3429418..3430212 Arthrobacter arilaitensis Re117 9796496 YP_003918231.1 CDS AARI_36060 NC_014550.1 3430285 3431331 R transposase of ISAar41, IS110 family complement(3430285..3431331) Arthrobacter arilaitensis Re117 9796497 YP_003918232.1 CDS AARI_36070 NC_014550.1 3431673 3431999 D transposase of ISAar40, IS3 family, IS3 group, orfA 3431673..3431999 Arthrobacter arilaitensis Re117 9793544 YP_003918233.1 CDS AARI_36080 NC_014550.1 3431999 3432910 D transposase of ISAar40, IS3 family, IS3 group, orfB 3431999..3432910 Arthrobacter arilaitensis Re117 9793545 YP_003918234.1 CDS AARI_30570 NC_014550.1 3433224 3433484 R signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.999 between position 30 and 31; hypothetical protein complement(3433224..3433484) Arthrobacter arilaitensis Re117 9793546 YP_003918235.1 CDS AARI_36090 NC_014550.1 3434070 3434909 R transposase of ISAar3, IS3 family, IS407 group, orfB complement(3434070..3434909) Arthrobacter arilaitensis Re117 9796498 YP_003918236.1 CDS AARI_36100 NC_014550.1 3434939 3435217 R transposase of ISAar3, IS3 family, IS407 group, orfA complement(3434939..3435217) Arthrobacter arilaitensis Re117 9793547 YP_003918237.1 CDS AARI_30580 NC_014550.1 3435884 3437017 R identified by match to PF04055. Radical SAM proteins catalyse diverse reactions, including unusual methylations, isomerisation, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation; radical SAM enzyme complement(3435884..3437017) Arthrobacter arilaitensis Re117 9793549 YP_003918238.1 CDS AARI_30590 NC_014550.1 3437319 3438437 R match to PR00420: Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature; aromatic-ring hydroxylase complement(3437319..3438437) Arthrobacter arilaitensis Re117 9796499 YP_003918239.1 CDS AARI_30600 NC_014550.1 3438430 3439143 R identified by match to protein domain PF08241; SAM-dependent methyltransferase complement(3438430..3439143) Arthrobacter arilaitensis Re117 9796500 YP_003918240.1 CDS AARI_30610 NC_014550.1 3439143 3440264 R identified by match to PIRSF000451. Type III polyketide synthases catalyse formation of structurally diverse polyketides; type III polyketide synthase complement(3439143..3440264) Arthrobacter arilaitensis Re117 9796501 YP_003918241.1 CDS AARI_30620 NC_014550.1 3440432 3441097 D identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator 3440432..3441097 Arthrobacter arilaitensis Re117 9796502 YP_003918242.1 CDS AARI_30650 NC_014550.1 3442149 3442811 R hypothetical protein complement(3442149..3442811) Arthrobacter arilaitensis Re117 9796505 YP_003918243.1 CDS AARI_30660 NC_014550.1 3442896 3444065 R 10 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3442896..3444065) Arthrobacter arilaitensis Re117 9796506 YP_003918244.1 CDS AARI_30670 NC_014550.1 3444118 3444861 R 7 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3444118..3444861) Arthrobacter arilaitensis Re117 9796507 YP_003918245.1 CDS AARI_30680 NC_014550.1 3444945 3446120 D sarcosine oxidase catalyzes the oxidative demethylation of sarcosine and forms equimolar amounts of formaldehyde, glycine and hydrogen peroxide; monomeric sarcosine oxidase 3444945..3446120 Arthrobacter arilaitensis Re117 9796508 YP_003918246.1 CDS AARI_30690 NC_014550.1 3446354 3446998 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.999) with cleavage site probability 0.472 between position 34 and 35; hypothetical protein 3446354..3446998 Arthrobacter arilaitensis Re117 9796509 YP_003918247.1 CDS AARI_30700 NC_014550.1 3447119 3447586 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3447119..3447586 Arthrobacter arilaitensis Re117 9796510 YP_003918248.1 CDS AARI_30710 NC_014550.1 3447907 3448380 D match to protein domain PF00746: Gram positive anchor. Surface proteins from Gram-positive cocci are covalently linked to the bacterial cell wall by sortase, a membrane-anchored transpeptidase that cleaves proteins between the threonine and the glycine of a conserved LPxTG motif, with the formation of a thioester between the conserved cysteine of sortase and the threonine carboxyl group. The newly liberated C-terminus of the threonine is transferred via an amide bond exchange to the amino group of the pentaglycine wall crossbridge, thereby tethering the C-terminus end of the surface protein to the bacterial peptidoglycan.The proteins that contain the conserved hexapeptide and hydrophobic anchor are diverse: they include M proteins, IgA and IgG binding proteins, fibronectin-binding proteins, wall-associated proteins, trypsin-resistant surface T protein, protein H precursor, etc.; cell surface protein 3447907..3448380 Arthrobacter arilaitensis Re117 9796511 YP_003918249.1 CDS AARI_30720 NC_014550.1 3448373 3448918 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.431 between position 38 and 39; hypothetical protein 3448373..3448918 Arthrobacter arilaitensis Re117 9796512 YP_003918250.1 CDS glsA NC_014550.1 3448942 3449970 R catalyzes the hydrolysis of glutamine to a glutamate and ammonia; glutaminase complement(3448942..3449970) Arthrobacter arilaitensis Re117 9796513 YP_003918251.1 CDS AARI_30740 NC_014550.1 3450179 3450601 D catalyzes the hydrolysis of the thioester bond in acyl-CoA thioesters; acyl-CoA thioester hydrolase 3450179..3450601 Arthrobacter arilaitensis Re117 9793916 YP_003918252.1 CDS AARI_30750 NC_014550.1 3450800 3451219 D lactoylglutathione lyase catalyzes the first step of the glyoxal pathway, the transformation of methylglyoxal and glutathione into S-lactoylglutathione which is then converted by glyoxalase II to lactic acid; lactoylglutathione lyase 3450800..3451219 Arthrobacter arilaitensis Re117 9796514 YP_003918253.1 CDS AARI_30760 NC_014550.1 3451227 3452066 R identified by match to protein family PF00657; GDSL-like lipase/esterase complement(3451227..3452066) Arthrobacter arilaitensis Re117 9796596 YP_003918254.1 CDS AARI_30790 NC_014550.1 3452849 3454123 D protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 4 transmembrane helices predicted by TMHMM2.0; signal transduction histidine kinase 3452849..3454123 Arthrobacter arilaitensis Re117 9796599 YP_003918255.1 CDS AARI_30800 NC_014550.1 3454111 3454800 D response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator 3454111..3454800 Arthrobacter arilaitensis Re117 9796600 YP_003918256.1 CDS AARI_30810 NC_014550.1 3454797 3455660 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3454797..3455660 Arthrobacter arilaitensis Re117 9796601 YP_003918257.1 CDS AARI_30820 NC_014550.1 3455787 3456614 R identified by match to protein family PF04012. This family includes PspA, which is a protein that suppresses sigma54-dependent transcription; pspA/IM30 family protein complement(3455787..3456614) Arthrobacter arilaitensis Re117 9796602 YP_003918258.1 CDS AARI_30830 NC_014550.1 3456699 3457418 R TCDB: ATP-binding cassette (ABC) superfamily (TC 3. A.1.y.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), NO family (NO family systems represent few ABC proteins with unknown function and which are apparently unrelated to existent families); ABC transporter ATP-binding subunit complement(3456699..3457418) Arthrobacter arilaitensis Re117 9796603 YP_003918259.1 CDS AARI_30840 NC_014550.1 3457531 3459429 R match to PR00420: Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature; aromatic-ring hydroxylase complement(3457531..3459429) Arthrobacter arilaitensis Re117 9796604 YP_003918260.1 CDS AARI_30850 NC_014550.1 3459598 3460266 D identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 3459598..3460266 Arthrobacter arilaitensis Re117 9793645 YP_003918261.1 CDS AARI_30860 NC_014550.1 3460267 3460431 R hypothetical protein complement(3460267..3460431) Arthrobacter arilaitensis Re117 9796605 YP_003918262.1 CDS AARI_30870 NC_014550.1 3460651 3461421 D hypothetical protein 3460651..3461421 Arthrobacter arilaitensis Re117 9796606 YP_003918263.1 CDS AARI_30880 NC_014550.1 3461418 3462671 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690 (Major Facilitator Superfamily); MFS superfamily transporter complement(3461418..3462671) Arthrobacter arilaitensis Re117 9796607 YP_003918264.1 CDS AARI_30890 NC_014550.1 3462775 3463233 R match to protein domain PF09424. This domain is found in GatB and proteins related to bacterial Yqey. GatB transamidates Glu-tRNA to Gln-tRNA. The function of this domain is uncertain, but Yqey and its relatives may have a role in tRNA metabolism; Yqey-like protein complement(3462775..3463233) Arthrobacter arilaitensis Re117 9796608 YP_003918265.1 CDS AARI_30900 NC_014550.1 3463345 3464769 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.593) with cleavage site probability 0.268 between position 39 and 40; hypothetical protein 3463345..3464769 Arthrobacter arilaitensis Re117 9796609 YP_003918266.1 CDS AARI_30910 NC_014550.1 3464766 3466046 R possible ATP-grasp enzyme; hypothetical protein complement(3464766..3466046) Arthrobacter arilaitensis Re117 9796610 YP_003918267.1 CDS AARI_30920 NC_014550.1 3466060 3467202 R identified by match to protein family PF02388. The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan. These proteins are also considered as a factor influencing the level of methicillin resistance; FemAB family protein complement(3466060..3467202) Arthrobacter arilaitensis Re117 9796611 YP_003918268.1 CDS AARI_30930 NC_014550.1 3467299 3467628 D hypothetical protein 3467299..3467628 Arthrobacter arilaitensis Re117 9796612 YP_003918269.1 CDS AARI_30940 NC_014550.1 3467688 3468002 D match to PF00403: Heavy-metal-associated domain. This domain has been found in a number of heavy metal transport or detoxification proteins; metal binding protein 3467688..3468002 Arthrobacter arilaitensis Re117 9796613 YP_003918270.1 CDS AARI_30950 NC_014550.1 3468060 3470318 D P-type ATPase (P-ATPase) superfamily (TC 3.A.3.y.z). Match to protein domain PF00403. Probably involved in export of cations such as Cu+ and Ag+; cation-transporting ATPase 3468060..3470318 Arthrobacter arilaitensis Re117 9796614 YP_003918271.1 CDS cycA NC_014550.1 3470968 3472470 D amino acid-polyamine-organocation (APC) superfamily, amino acid transporter (AAT) family, D- Serine/D-alanine/glycine:H+ symporter (TC 2.A.3.1.7). Identified by similarity to protein SP:P0AAE0 (Escherichia coli); D-serine/D-alanine/glycine transporter 3470968..3472470 Arthrobacter arilaitensis Re117 9796615 YP_003918272.1 CDS AARI_30970 NC_014550.1 3472517 3472849 D hypothetical protein 3472517..3472849 Arthrobacter arilaitensis Re117 9793770 YP_003918273.1 CDS AARI_30990 NC_014550.1 3473222 3474220 R 9 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3473222..3474220) Arthrobacter arilaitensis Re117 9796617 YP_003918274.1 CDS AARI_31000 NC_014550.1 3474335 3474886 D hypothetical protein 3474335..3474886 Arthrobacter arilaitensis Re117 9796618 YP_003918275.1 CDS AARI_31010 NC_014550.1 3474974 3475282 D hypothetical protein 3474974..3475282 Arthrobacter arilaitensis Re117 9796619 YP_003918276.1 CDS rraA NC_014550.1 3475299 3475775 R identified by match to protein family TIGR01935: ribonuclease E inhibitor RraA.The Escherichia coli member of this family has been characterised as a regulator of RNase E, and its crystal structure has been analysed. It acts as a trans-acting modulator of RNA turnover, binding essential endonuclease RNase E and inhibiting RNA processing. RNase E forms the core of a large RNA- catalysis machine termed the degradosomes. RraA (and RraB) causes remodelling of degradosome composition, which is associated with alterations in RNA decay and global transcript abundance and as such is a bacterial mechanism for the regulation of RNA cleavage; ribonuclease activity regulator protein RraA complement(3475299..3475775) Arthrobacter arilaitensis Re117 9796620 YP_003918277.1 CDS AARI_31030 NC_014550.1 3475868 3477361 R amino acid-polyamine-organocation (APC) superfamily (TC 2.A.3.y.z); amino acid transporter complement(3475868..3477361) Arthrobacter arilaitensis Re117 9794368 YP_003918278.1 CDS AARI_31040 NC_014550.1 3477470 3477712 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3477470..3477712) Arthrobacter arilaitensis Re117 9796621 YP_003918279.1 CDS AARI_31050 NC_014550.1 3477802 3478395 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3477802..3478395) Arthrobacter arilaitensis Re117 9796622 YP_003918280.1 CDS lldD NC_014550.1 3478451 3479671 R catalyses the conversion of L-lactate to pyruvate. Probable quinone-dependent lactate dehydrogenase, functionning when lactate is used as a carbon and energy source; L-lactate dehydrogenase complement(3478451..3479671) Arthrobacter arilaitensis Re117 9796623 YP_003918281.1 CDS AARI_31070 NC_014550.1 3479702 3481015 R major facilitator superfamily (MFS), metabolite:H+ symporter (MHS) family (TC 2.A.1.6.z); MFS superfamily transporter complement(3479702..3481015) Arthrobacter arilaitensis Re117 9794041 YP_003918282.1 CDS AARI_31080 NC_014550.1 3481146 3481781 D identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator 3481146..3481781 Arthrobacter arilaitensis Re117 9796624 YP_003918283.1 CDS AARI_31090 NC_014550.1 3481887 3483227 R Multi Antimicrobial Extrusion (MATE) Family protein (TC 2.A.66.1.z). Characterised members of the MATE family function as drug/sodium antiporters. These proteins mediate resistance to a wide range of cationic dyes, fluroquinolones, aminoglycosides and other structurally diverse antibodies and drugs; drug/sodium antiporter complement(3481887..3483227) Arthrobacter arilaitensis Re117 9796625 YP_003918284.1 CDS AARI_31100 NC_014550.1 3483433 3484221 D hypothetical protein 3483433..3484221 Arthrobacter arilaitensis Re117 9796626 YP_003918285.1 CDS AARI_31110 NC_014550.1 3484266 3485465 R major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter complement(3484266..3485465) Arthrobacter arilaitensis Re117 9796627 YP_003918286.1 CDS AARI_31120 NC_014550.1 3485469 3486239 R identified by match to protein family PF02517: CAAX amino terminal protease family. Members of this family are probably proteases (after a prenyl group is attached to the Cys residue in the C-terminal CAAX motif of a protein, the AAX tripeptide is removed by one of the CAAX prenyl proteases). The family contains the Q03530 CAAX prenyl protease. 7 transmembrane helices predicted by TMHMM2.0; CAAX amino terminal protease family protein complement(3485469..3486239) Arthrobacter arilaitensis Re117 9796628 YP_003918287.1 CDS AARI_31130 NC_014550.1 3486311 3487603 R match to PF08239: bacterial SH3 domain. A homologue of the SH3 domain has been found in a number of different bacterial proteins including glycyl-glycine endopeptidase, bacteriocin and some hypothetical proteins. Signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.812 between position 33 and 34; SH3 domain-containing protein complement(3486311..3487603) Arthrobacter arilaitensis Re117 9796629 YP_003918288.1 CDS AARI_31140 NC_014550.1 3488155 3490245 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, LLP- subfamily (LIP-like exporters). The function of LIP-like exporters is presently unknown; ABC transporter ATPase and permease components complement(3488155..3490245) Arthrobacter arilaitensis Re117 9796630 YP_003918289.1 CDS AARI_31150 NC_014550.1 3490246 3491979 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, LLP- subfamily (LIP-like exporters). The function of LIP-like exporters is presently unknown; ABC transporter ATPase and permease components complement(3490246..3491979) Arthrobacter arilaitensis Re117 9796631 YP_003918290.1 CDS AARI_31180 NC_014550.1 3493613 3494263 R match to protein family PF01329: pterin 4 alpha carbinolamine dehydratase; hypothetical protein complement(3493613..3494263) Arthrobacter arilaitensis Re117 9796634 YP_003918291.1 CDS AARI_31190 NC_014550.1 3494448 3494984 D hypothetical protein 3494448..3494984 Arthrobacter arilaitensis Re117 9796635 YP_003918292.1 CDS AARI_31200 NC_014550.1 3494985 3495440 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3494985..3495440 Arthrobacter arilaitensis Re117 9796636 YP_003918293.1 CDS AARI_31210 NC_014550.1 3495488 3495814 R hypothetical protein complement(3495488..3495814) Arthrobacter arilaitensis Re117 9796637 YP_003918294.1 CDS AARI_31220 NC_014550.1 3495817 3496410 R identified by match to protein family PF00857. This is a family of hydrolase enzymes. Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate; isochorismatase family protein complement(3495817..3496410) Arthrobacter arilaitensis Re117 9796638 YP_003918295.1 CDS AARI_31230 NC_014550.1 3496612 3496860 R hypothetical protein complement(3496612..3496860) Arthrobacter arilaitensis Re117 9796639 YP_003918296.1 CDS AARI_31240 NC_014550.1 3497062 3497310 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3497062..3497310) Arthrobacter arilaitensis Re117 9796640 YP_003918297.1 CDS AARI_31250 NC_014550.1 3497338 3497493 R hypothetical protein complement(3497338..3497493) Arthrobacter arilaitensis Re117 9796641 YP_003918298.1 CDS AARI_31260 NC_014550.1 3497522 3497788 R hypothetical protein complement(3497522..3497788) Arthrobacter arilaitensis Re117 9796642 YP_003918299.1 CDS AARI_31270 NC_014550.1 3498103 3499044 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein 3498103..3499044 Arthrobacter arilaitensis Re117 9796643 YP_003918300.1 CDS AARI_31280 NC_014550.1 3499150 3500283 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3499150..3500283) Arthrobacter arilaitensis Re117 9796644 YP_003918301.1 CDS AARI_31290 NC_014550.1 3500404 3500685 D hypothetical protein 3500404..3500685 Arthrobacter arilaitensis Re117 9796645 YP_003918302.1 CDS AARI_31300 NC_014550.1 3500728 3501900 D identified by match to PF08240 and PF00107. Zn- dependent alcohol dehydrogenasescatalyse the following reaction: an alcohol + NAD(+) <=> an aldehyde or ketone + NADH; Zn-dependent alcohol dehydrogenase 3500728..3501900 Arthrobacter arilaitensis Re117 9796646 YP_003918303.1 CDS AARI_31330 NC_014550.1 3502945 3503202 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3502945..3503202 Arthrobacter arilaitensis Re117 9796649 YP_003918304.1 CDS bcp NC_014550.1 3503399 3503875 D peroxiredoxin protects cells against toxicity from reactive oxygen species by reducing and detoxifying hydroperoxides. The Bcp protein shows substrate selectivity toward fatty acid hydroperoxides rather than hydrogen peroxide or alkyl hydroperoxides; peroxiredoxin Bcp 3503399..3503875 Arthrobacter arilaitensis Re117 9796650 YP_003918305.1 CDS gabD NC_014550.1 3503973 3505343 R succinate-semialdehyde dehydrogenase (NAD(P)(+)) reduces succinate semialdehyde into succinate. Involved in the degradation of gamma-aminobutyrate; succinate-semialdehyde dehydrogenase complement(3503973..3505343) Arthrobacter arilaitensis Re117 9793708 YP_003918306.1 CDS AARI_31360 NC_014550.1 3505946 3507340 D identified by match to PF03441 and PF00875. DNA photolyases are enzymes that bind to DNA containing pyrimidine dimers: on absorption of visible light, they catalyse dimer splitting into the constituent monomers, a process called photoreactivation. This is a DNA repair mechanism, repairing mismatched pyrimidine dimers induced by exposure to ultra-violet light; deoxyribodipyrimidine photo-lyase 3505946..3507340 Arthrobacter arilaitensis Re117 9793877 YP_003918307.1 CDS AARI_31370 NC_014550.1 3507726 3508160 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3507726..3508160 Arthrobacter arilaitensis Re117 9796651 YP_003918308.1 CDS AARI_31380 NC_014550.1 3508157 3508831 D 5 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3508157..3508831 Arthrobacter arilaitensis Re117 9796652 YP_003918309.1 CDS bdh NC_014550.1 3508892 3509953 R synonym: acetoin reductase. Catalyzes the production of 2,3-butanediol from acetoin. Identified by similarity to protein SP:O34788 (Bacillus subtilis); (R,R)-butanediol dehydrogenase complement(3508892..3509953) Arthrobacter arilaitensis Re117 9796653 YP_003918310.1 CDS vsr NC_014550.1 3510149 3510556 D very short patch repair endonucleases recognises a TG mismatched base pair, generated after spontaneous deamination of methylated cytosines, and cleaves the phosphate backbone on the 5 prime side of the thymine; very short patch repair endonuclease 3510149..3510556 Arthrobacter arilaitensis Re117 9793709 YP_003918311.1 CDS AARI_31410 NC_014550.1 3510736 3512019 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter 3510736..3512019 Arthrobacter arilaitensis Re117 9794501 YP_003918312.1 CDS AARI_31420 NC_014550.1 3512236 3513777 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter substrate-binding protein 3512236..3513777 Arthrobacter arilaitensis Re117 9796654 YP_003918313.1 CDS AARI_31430 NC_014550.1 3513779 3514732 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 3513779..3514732 Arthrobacter arilaitensis Re117 9796655 YP_003918314.1 CDS AARI_31440 NC_014550.1 3514713 3515576 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter inner membrane subunit 3514713..3515576 Arthrobacter arilaitensis Re117 9796656 YP_003918315.1 CDS AARI_31450 NC_014550.1 3515569 3517107 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, fused ATP-binding protein (ABC2), OPN-family (oligopeptides and nickel), oligopeptides import; dipeptide/oligopeptide ABC transporter ATP-binding subunit 3515569..3517107 Arthrobacter arilaitensis Re117 9796657 YP_003918316.1 CDS AARI_31460 NC_014550.1 3517411 3517596 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(3517411..3517596) Arthrobacter arilaitensis Re117 9796658 YP_003918317.1 CDS AARI_31470 NC_014550.1 3517661 3518422 D identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 3517661..3518422 Arthrobacter arilaitensis Re117 9796659 YP_003918318.1 CDS pyrDI NC_014550.1 3519101 3520090 D dihydroorotate oxidase catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. In some organisms such as Bacillus subtilis, dihydroorotate oxidase is composed of two subunits: PyrDI and PyrDII; dihydroorotate oxidase catalytic subunit 3519101..3520090 Arthrobacter arilaitensis Re117 9796660 YP_003918319.1 CDS AARI_31490 NC_014550.1 3520087 3521361 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter 3520087..3521361 Arthrobacter arilaitensis Re117 9794268 YP_003918320.1 CDS AARI_31500 NC_014550.1 3521420 3521947 D hypothetical protein 3521420..3521947 Arthrobacter arilaitensis Re117 9796661 YP_003918321.1 CDS AARI_31510 NC_014550.1 3521940 3522443 D hypothetical protein 3521940..3522443 Arthrobacter arilaitensis Re117 9796662 YP_003918322.1 CDS AARI_31520 NC_014550.1 3522511 3523725 D allantoate deiminase catalyses the conversion of allantoate in ammonia, carbon dioxide andureidoglycolate. Involved in purine degradation; allantoate deiminase 3522511..3523725 Arthrobacter arilaitensis Re117 9796663 YP_003918323.1 CDS pyrDII NC_014550.1 3523735 3524634 D dihydroorotate oxidase catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. In some organisms such as Bacillus subtilis, dihydroorotate oxidase is composed of two subunits: PyrDI and PyrDII; dihydroorotate oxidase electron transfer subunit 3523735..3524634 Arthrobacter arilaitensis Re117 9796664 YP_003918324.1 CDS pyrC NC_014550.1 3524631 3525956 D catalyzes the third step in the de novo biosynthesis of pyrimidine, the conversion of N-carbamoyl- L-aspartate into dihydroorotate; dihydroorotase 3524631..3525956 Arthrobacter arilaitensis Re117 9794269 YP_003918325.1 CDS aspA NC_014550.1 3525964 3527418 D catalyzes the reversible conversion of aspartate to fumarate and ammonia; aspartate ammonia-lyase 3525964..3527418 Arthrobacter arilaitensis Re117 9794266 YP_003918326.1 CDS pheC NC_014550.1 3527634 3528473 D identified by similarity to protein SP:Q01269 (Pseudomonas aeruginosa). Forms an alternative pathway for phenylalanine biosynthesis. Can catalyze two reactions: prephenate dehydratase (EC 4.2.1.51: Prephenate = phenylpyruvate + H2O + CO2) and arogenate dehydratase (EC 4.2.1.91: L-arogenate = L-phenylalanine + H2O + CO2); cyclohexadienyl dehydratase 3527634..3528473 Arthrobacter arilaitensis Re117 9793696 YP_003918327.1 CDS AARI_31570 NC_014550.1 3528577 3529350 R identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein complement(3528577..3529350) Arthrobacter arilaitensis Re117 9794203 YP_003918328.1 CDS AARI_31580 NC_014550.1 3529596 3530933 D major facilitator superfamily (MFS), metabolite:H+ symporter (MHS) family (TC 2.A.1.6.z); MFS superfamily transporter 3529596..3530933 Arthrobacter arilaitensis Re117 9796665 YP_003918329.1 CDS AARI_31590 NC_014550.1 3530987 3531871 D identified by match to PF00456: transketolase, thiamine diphosphate binding domain; transketolase subunit A 3530987..3531871 Arthrobacter arilaitensis Re117 9796666 YP_003918330.1 CDS AARI_31600 NC_014550.1 3531872 3532864 D identified by match to PF02779 (transketolase, pyrimidine binding domain) and PF02780 (transketolase, C- terminal domain); transketolase subunit B 3531872..3532864 Arthrobacter arilaitensis Re117 9796667 YP_003918331.1 CDS AARI_31610 NC_014550.1 3532988 3533650 D identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator 3532988..3533650 Arthrobacter arilaitensis Re117 9796668 YP_003918332.1 CDS AARI_31620 NC_014550.1 3534299 3534952 D match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein 3534299..3534952 Arthrobacter arilaitensis Re117 9796669 YP_003918333.1 CDS AARI_31630 NC_014550.1 3534949 3536235 D identified by match to PF07804 (HipA-like C- terminal domain) and PF07805 (HipA-like N-terminal domain). The HipA protein is known to be involved in high- frequency persistence to the lethal effects of inhibition of either DNA or peptidoglycan synthesis. When expressed alone, it is toxic to bacterial cells but it is usually tightly associated with HipB and the HipA-HipB complex may be involved in autoregulation of the hip operon. The hip proteins may be involved in cell division control and may interact with cell division genes or their products; HipA-like protein 3534949..3536235 Arthrobacter arilaitensis Re117 9796670 YP_003918334.1 CDS AARI_31640 NC_014550.1 3536325 3537398 R match to protein family PF00724: NADH:flavin oxidoreductase / NADH oxidase family; flavin oxidoreductase complement(3536325..3537398) Arthrobacter arilaitensis Re117 9796671 YP_003918335.1 CDS AARI_31650 NC_014550.1 3537564 3538316 R identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein complement(3537564..3538316) Arthrobacter arilaitensis Re117 9796672 YP_003918336.1 CDS AARI_31660 NC_014550.1 3538442 3539824 R TC 3.A.1.y.z. ABCISSE: ABC transporter, fused ATP- binding protein (ABC2), CBY-family (Cobalt uptake, unknown), Y179-subfamily (CBU-like systems). The function of CBU-like systems is unknown; ABC transporter ATP-binding subunit complement(3538442..3539824) Arthrobacter arilaitensis Re117 9796673 YP_003918337.1 CDS AARI_31670 NC_014550.1 3539827 3540585 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM), CBY-family (Cobalt uptake, unknown), Y179-subfamily (CBU-like systems). The function of CBU-like systems is unknown; ABC transporter inner membrane subunit complement(3539827..3540585) Arthrobacter arilaitensis Re117 9796674 YP_003918338.1 CDS AARI_31680 NC_014550.1 3540596 3541342 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3540596..3541342) Arthrobacter arilaitensis Re117 9796675 YP_003918339.1 CDS AARI_31690 NC_014550.1 3541523 3542620 R catalyzes the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates; purine nucleosidase complement(3541523..3542620) Arthrobacter arilaitensis Re117 9796676 YP_003918340.1 CDS AARI_31700 NC_014550.1 3542683 3545670 R possible DNA or RNA helicase; ATP-dependent helicase complement(3542683..3545670) Arthrobacter arilaitensis Re117 9796758 YP_003918341.1 CDS AARI_31710 NC_014550.1 3545667 3546059 R identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase complement(3545667..3546059) Arthrobacter arilaitensis Re117 9796759 YP_003918342.1 CDS dgoT NC_014550.1 3546279 3547601 R major facilitator superfamily (MFS), Anion:Cation Symporter (ACS) Family, galactonate uptake (TC 2.A.1.14.7); D-galactonate transporter complement(3546279..3547601) Arthrobacter arilaitensis Re117 9796760 YP_003918343.1 CDS dgoD NC_014550.1 3547607 3548755 R catalyzes the first reaction in the D-galactonate catabolic pathway; galactonate dehydratase complement(3547607..3548755) Arthrobacter arilaitensis Re117 9793808 YP_003918344.1 CDS dgoA NC_014550.1 3548752 3549396 R catalyzes the third reaction in the D-galactonate catabolic pathway; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(3548752..3549396) Arthrobacter arilaitensis Re117 9793806 YP_003918345.1 CDS dgoK NC_014550.1 3549438 3550430 R catalyzes the second reaction in the D-galactonate catabolic pathway; 2-dehydro-3-deoxygalactonokinase complement(3549438..3550430) Arthrobacter arilaitensis Re117 9793805 YP_003918346.1 CDS AARI_31760 NC_014550.1 3550581 3551378 D identified by match to PF09339: IclR helix-turn- helix domain. This family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 3550581..3551378 Arthrobacter arilaitensis Re117 9793807 YP_003918347.1 CDS AARI_31770 NC_014550.1 3552452 3553156 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OPN-family (oligopeptides and nickel); ABC transporter ATP-binding subunit 3552452..3553156 Arthrobacter arilaitensis Re117 9793551 YP_003918348.1 CDS AARI_31780 NC_014550.1 3553153 3553857 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), OPN-family (oligopeptides and nickel); ABC transporter ATP-binding subunit 3553153..3553857 Arthrobacter arilaitensis Re117 9796762 YP_003918349.1 CDS AARI_31790 NC_014550.1 3553854 3555371 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, binding protein (BP), OPN-family (oligopeptides and nickel); ABC transporter substrate-binding protein 3553854..3555371 Arthrobacter arilaitensis Re117 9796763 YP_003918350.1 CDS AARI_31800 NC_014550.1 3555384 3557228 D TCDB: ATP-binding cassette (ABC) superfamily, peptide/opine/nickel uptake transporter (PepT) family (TC 3.A.1.5.z). ABCISSE: ABC transporter, permease (IM), OPN- family (oligopeptides and nickel); ABC transporter inner membrane subunit 3555384..3557228 Arthrobacter arilaitensis Re117 9796764 YP_003918351.1 CDS AARI_31810 NC_014550.1 3557332 3558417 R possible glutamate--cysteine ligase (6.3.2.2). Match to protein family PF04107: glutamate-cysteine ligase family 2(GCS2); carboxylate-amine ligase complement(3557332..3558417) Arthrobacter arilaitensis Re117 9796765 YP_003918352.1 CDS AARI_31820 NC_014550.1 3558805 3559563 D hypothetical protein 3558805..3559563 Arthrobacter arilaitensis Re117 9796766 YP_003918353.1 CDS AARI_31830 NC_014550.1 3559823 3560101 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3559823..3560101 Arthrobacter arilaitensis Re117 9796767 YP_003918354.1 CDS AARI_31840 NC_014550.1 3560124 3560432 R hypothetical protein complement(3560124..3560432) Arthrobacter arilaitensis Re117 9796768 YP_003918355.1 CDS AARI_31850 NC_014550.1 3560614 3560814 R identified by match to SM00705: CDGSH-type zinc finger domain. Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. The CDGSH-type zinc finger contains a CDGSH sequence motif (although the Ser residue can also be an Ala or Thr), and is found in proteins from a wide range of organisms with the exception of fungi. Proteins carrying this domain include ferredoxin-dependent glutamate synthase. CDGSH-type domains are also found in the iron-containing outer membrane protein mitoNEET. MitoNEET contains the conserved sequence C-X-C-X2-(S/T)-X3- P-X-C-D-G-(S/A/T)-H, a defining feature of CDGSH domains, and is likely involved in iron binding rather than zinc binding; zinc finger domain-containing protein complement(3560614..3560814) Arthrobacter arilaitensis Re117 9796769 YP_003918356.1 CDS AARI_31860 NC_014550.1 3560811 3561839 R hypothetical protein complement(3560811..3561839) Arthrobacter arilaitensis Re117 9796770 YP_003918357.1 CDS AARI_31870 NC_014550.1 3562052 3562606 R match to protein family TIGR01382. A role in the degradation of small peptides has been suggested; PfpI family intracellular protease complement(3562052..3562606) Arthrobacter arilaitensis Re117 9796771 YP_003918358.1 CDS AARI_31880 NC_014550.1 3563256 3563696 D hypothetical protein 3563256..3563696 Arthrobacter arilaitensis Re117 9796772 YP_003918359.1 CDS AARI_31890 NC_014550.1 3564041 3564202 D hypothetical protein 3564041..3564202 Arthrobacter arilaitensis Re117 9796773 YP_003918360.1 CDS nhaA NC_014550.1 3564289 3565560 D NhaA Na+:H+antiporter (NhaA) family (TC 2.A.33.y.z). Na(+)/H(+) antiporter extrudes sodium in exchange for external protons. Active at alkaline pH. In E. coli, NhaA protein probably functions in the regulation of the internal pH when the external pH is alkaline. It also uses the H+ gradient to expel Na+ from the cell. Its activity is highly pH dependent; Na+/H+ antiporter NhaA 3564289..3565560 Arthrobacter arilaitensis Re117 9796774 YP_003918361.1 CDS pstS NC_014550.1 3565639 3566781 R TCDB: ATP-binding cassette (ABC) superfamily, phosphate uptake transporter (PhoT) family, phosphate transporter (TC 3.A.1.7.2). ABCISSE: ABC transporter, binding protein (BP), MOI-family, phosphate import. Part of an ABC transporter complex involved in phosphate import; phosphate ABC transporter substrate-binding protein PstS complement(3565639..3566781) Arthrobacter arilaitensis Re117 9794140 YP_003918362.1 CDS AARI_31920 NC_014550.1 3567297 3567557 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3567297..3567557 Arthrobacter arilaitensis Re117 9794239 YP_003918363.1 CDS AARI_31930 NC_014550.1 3567702 3568133 R hypothetical protein complement(3567702..3568133) Arthrobacter arilaitensis Re117 9796775 YP_003918364.1 CDS AARI_31940 NC_014550.1 3568578 3569717 D possible glutamate--cysteine ligase (6.3.2.2). Match to protein family PF04107: glutamate-cysteine ligase family 2(GCS2); carboxylate-amine ligase 3568578..3569717 Arthrobacter arilaitensis Re117 9796776 YP_003918365.1 CDS AARI_31950 NC_014550.1 3569738 3571171 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.502) with cleavage site probability 0.387 between position 20 and 21; hypothetical protein complement(3569738..3571171) Arthrobacter arilaitensis Re117 9796777 YP_003918366.1 CDS arsC NC_014550.1 3571214 3571636 R ArsC reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low- MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances; arsenate reductase complement(3571214..3571636) Arthrobacter arilaitensis Re117 9796778 YP_003918367.1 CDS arsB NC_014550.1 3571642 3572724 R Arsenical Resistance-3 (ACR3) Family, ArsB arsenite/antimonite exporter (TC 2.A.59.1.2). Identified by similarity to protein SP: P45946 (Bacillus subtilis). Confers resistance to arsenite by allowing cells to extrude this compound; arsenite resistance protein ArsB complement(3571642..3572724) Arthrobacter arilaitensis Re117 9793692 YP_003918368.1 CDS AARI_31980 NC_014550.1 3572836 3573210 D identified by match to PF01022: bacterial regulatory protein, ArsR family. ArsR-family transcriptional regulators include several proteins that appear to dissociate from DNA in the presence of metal ions; ArsR family transcriptional regulator 3572836..3573210 Arthrobacter arilaitensis Re117 9793691 YP_003918369.1 CDS AARI_31990 NC_014550.1 3573374 3573637 R identified by match to SM00705: CDGSH-type zinc finger domain. Zinc finger (Znf) domains are relatively small protein motifs that bind one or more zinc atoms, and which usually contain multiple finger-like protrusions that make tandem contacts with their target molecule. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis, however they are now recognised to bind DNA, RNA, protein and/or lipid substrates. The CDGSH-type zinc finger contains a CDGSH sequence motif (although the Ser residue can also be an Ala or Thr), and is found in proteins from a wide range of organisms with the exception of fungi. Proteins carrying this domain include ferredoxin-dependent glutamate synthase. CDGSH-type domains are also found in the iron-containing outer membrane protein mitoNEET. MitoNEET contains the conserved sequence C-X-C-X2-(S/T)-X3- P-X-C-D-G-(S/A/T)-H, a defining feature of CDGSH domains, and is likely involved in iron binding rather than zinc binding; zinc finger domain-containing protein complement(3573374..3573637) Arthrobacter arilaitensis Re117 9796779 YP_003918370.1 CDS AARI_32000 NC_014550.1 3573634 3574497 R hypothetical protein complement(3573634..3574497) Arthrobacter arilaitensis Re117 9796780 YP_003918371.1 CDS AARI_32010 NC_014550.1 3574782 3575282 D hypothetical protein 3574782..3575282 Arthrobacter arilaitensis Re117 9796781 YP_003918372.1 CDS AARI_32020 NC_014550.1 3575634 3575849 D hypothetical protein 3575634..3575849 Arthrobacter arilaitensis Re117 9796782 YP_003918373.1 CDS AARI_32030 NC_014550.1 3575972 3576934 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3575972..3576934) Arthrobacter arilaitensis Re117 9796783 YP_003918374.1 CDS AARI_32040 NC_014550.1 3576931 3577362 R hypothetical protein complement(3576931..3577362) Arthrobacter arilaitensis Re117 9796784 YP_003918375.1 CDS AARI_36140 NC_014550.1 3577499 3578578 R transposase of ISAar18, IS110 family complement(3577499..3578578) Arthrobacter arilaitensis Re117 9796785 YP_003918376.1 CDS AARI_36150 NC_014550.1 3579025 3580221 D transposase of ISAar17, IS110 family 3579025..3580221 Arthrobacter arilaitensis Re117 9793552 YP_003918377.1 CDS AARI_32060 NC_014550.1 3580868 3582076 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter 3580868..3582076 Arthrobacter arilaitensis Re117 9796786 YP_003918378.1 CDS AARI_32070 NC_014550.1 3582146 3583189 R possible transporter. Match to PF00571 (CBS domain pair); CBS domain-containing transporter complement(3582146..3583189) Arthrobacter arilaitensis Re117 9796787 YP_003918379.1 CDS AARI_32080 NC_014550.1 3583186 3584532 R possible transporter. Match to PF00571 (CBS domain pair); CBS domain-containing transporter complement(3583186..3584532) Arthrobacter arilaitensis Re117 9796788 YP_003918380.1 CDS AARI_32090 NC_014550.1 3584862 3586094 D glutaminase catalyzes the hydrolysis of glutamine to a glutamate and ammonia; glutaminase 3584862..3586094 Arthrobacter arilaitensis Re117 9796789 YP_003918381.1 CDS AARI_32100 NC_014550.1 3586103 3588007 R N-terminal section of the protein: COG4781 (membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase); 7 transmembrane helices predicted by TMHMM2.0. C-terminal section of the protein: match to PF03009 (glycerophosphoryl diester phosphodiesterase family). Escherichia coli has two sequence related isozymes of glycerophosphoryl diester phosphodiesterase (GDPD) - periplasmic and cytosolic. glycerophosphoryl diester phosphodiesterases display broad specificity for glycerophosphodiesters; glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoglycerol, and bis(glycerophosphoglycerol); periplasmic glycerophosphoryl diester phosphodiesterase complement(3586103..3588007) Arthrobacter arilaitensis Re117 9796790 YP_003918382.1 CDS AARI_32110 NC_014550.1 3588128 3588598 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.992) with cleavage site probability 0.758 between position 37 and 38; hypothetical protein complement(3588128..3588598) Arthrobacter arilaitensis Re117 9796791 YP_003918383.1 CDS AARI_32120 NC_014550.1 3588925 3589842 D identified by match to PF00296. Bacterial luciferase is a flavin monooxygenase that catalyses the oxidation of long-chain aldehydes and releases energy in the form of visible light, and which uses flavin as a substrate rather than a cofactor. There are structural similarities between bacterial luciferase and nonfluorescent flavoproteins (LuxF, FP390), alkanesulfonate monooxygenase (SsuD), and coenzyme F420- dependent terahydromethanopterin reductase, which make up clearly related families with somewhat different folds; luciferase-like monooxygenase 3588925..3589842 Arthrobacter arilaitensis Re117 9796792 YP_003918384.1 CDS AARI_32130 NC_014550.1 3590116 3590808 R hypothetical protein complement(3590116..3590808) Arthrobacter arilaitensis Re117 9796793 YP_003918385.1 CDS AARI_36160 NC_014550.1 3591039 3592436 R transposase of ISAar12, IS1380 family complement(3591039..3592436) Arthrobacter arilaitensis Re117 9796794 YP_003918386.1 CDS AARI_32140 NC_014550.1 3593130 3594275 R identified by match to protein family PF00246: zinc carboxypeptidase; carboxypeptidase complement(3593130..3594275) Arthrobacter arilaitensis Re117 9793554 YP_003918387.1 CDS AARI_32150 NC_014550.1 3594275 3594760 R hypothetical protein complement(3594275..3594760) Arthrobacter arilaitensis Re117 9796795 YP_003918388.1 CDS AARI_32160 NC_014550.1 3594762 3596309 R Solute:Sodium Symporter (SSS) family (2.A.21.y.z). Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, organo cations such as choline, nucleosides, inositols, vitamins, urea or anions, depending on the system; Na+/solute symporter complement(3594762..3596309) Arthrobacter arilaitensis Re117 9796796 YP_003918389.1 CDS AARI_32170 NC_014550.1 3596537 3598138 D identified by match to PF07905: purine catabolism regulatory protein-like family. The bacterial proteins found in this family are similar to the purine catabolism regulatory protein expressed by Bacillus subtilis (PucR, O32138). PucR is thought to be a transcriptional activator involved in the induction of the purine degradation pathway, and may contain a LysR-like DNA-binding domain. It is similar to LysR-type regulators in that it represses its own expression. The other members of this family are also annotated as being regulatory proteins; transcriptional regulator 3596537..3598138 Arthrobacter arilaitensis Re117 9796797 YP_003918390.1 CDS purU NC_014550.1 3598230 3599102 R catalyses the following reaction: 10- formyltetrahydrofolate + H(2)O <=> formate + tetrahydrofolate; formyltetrahydrofolate deformylase complement(3598230..3599102) Arthrobacter arilaitensis Re117 9796798 YP_003918391.1 CDS AARI_32190 NC_014550.1 3599543 3600211 D identified by match to protein family PF00392. This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector- binding/oligomerisation domain. The GntR-like proteins can be divided into six sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships; GntR family transcriptional regulator 3599543..3600211 Arthrobacter arilaitensis Re117 9794259 YP_003918392.1 CDS AARI_32220 NC_014550.1 3601800 3602096 R hypothetical protein complement(3601800..3602096) Arthrobacter arilaitensis Re117 9796801 YP_003918393.1 CDS AARI_32230 NC_014550.1 3602199 3602729 R hypothetical protein complement(3602199..3602729) Arthrobacter arilaitensis Re117 9796802 YP_003918394.1 CDS AARI_32240 NC_014550.1 3602809 3605301 R C-terminal part of the protein: Sigma 70 regions 2 and 4 (PF04542, PF08281). Presence of numerous PT repeats (XPTX) at the C-terminal part of the protein; RNA polymerase sigma factor complement(3602809..3605301) Arthrobacter arilaitensis Re117 9796803 YP_003918395.1 CDS AARI_32250 NC_014550.1 3605711 3607018 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(3605711..3607018) Arthrobacter arilaitensis Re117 9796804 YP_003918396.1 CDS AARI_32260 NC_014550.1 3607015 3608379 R match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 complement(3607015..3608379) Arthrobacter arilaitensis Re117 9796805 YP_003918397.1 CDS AARI_32270 NC_014550.1 3608376 3609296 R hypothetical protein complement(3608376..3609296) Arthrobacter arilaitensis Re117 9796806 YP_003918398.1 CDS AARI_32280 NC_014550.1 3609296 3610210 R LmbE-like protein complement(3609296..3610210) Arthrobacter arilaitensis Re117 9796807 YP_003918399.1 CDS AARI_36180 NC_014550.1 3611989 3613296 R transposase of ISAar19, ISL3 family complement(3611989..3613296) Arthrobacter arilaitensis Re117 9793555 YP_003918400.1 CDS AARI_32290 NC_014550.1 3613522 3618252 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3613522..3618252) Arthrobacter arilaitensis Re117 9793556 YP_003918401.1 CDS AARI_32300 NC_014550.1 3618739 3619914 R match to PF00196: bacterial regulatory proteins, luxR family. This domain is a DNA-binding, helix-turn- helix (HTH) domain of about 65 amino acids, present in transcription regulators of the LuxR/FixJ family of response regulators; hypothetical protein complement(3618739..3619914) Arthrobacter arilaitensis Re117 9796809 YP_003918402.1 CDS AARI_32310 NC_014550.1 3620020 3621045 R hypothetical protein complement(3620020..3621045) Arthrobacter arilaitensis Re117 9796810 YP_003918403.1 CDS AARI_32320 NC_014550.1 3621165 3621479 R 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein complement(3621165..3621479) Arthrobacter arilaitensis Re117 9796811 YP_003918404.1 CDS allB NC_014550.1 3621738 3623120 R hydrolyzes allantoin into allantoate. Involved in purine degradation; allantoinase complement(3621738..3623120) Arthrobacter arilaitensis Re117 9796812 YP_003918405.1 CDS gcl NC_014550.1 3623272 3625065 R catalyses the following reaction: 2 glyoxylate <=> tartronate semialdehyde + CO(2); tartronate-semialdehyde synthase complement(3623272..3625065) Arthrobacter arilaitensis Re117 9793663 YP_003918406.1 CDS AARI_32350 NC_014550.1 3625128 3625319 D hypothetical protein 3625128..3625319 Arthrobacter arilaitensis Re117 9793890 YP_003918407.1 CDS AARI_32360 NC_014550.1 3625335 3626234 R catalyses the following reaction: (R)-glycerate + NAD(P)(+) <=> 2-hydroxy-3-oxopropanoate + NAD(P)H; 2-hydroxy-3-oxopropionate reductase complement(3625335..3626234) Arthrobacter arilaitensis Re117 9796813 YP_003918408.1 CDS AARI_32370 NC_014550.1 3626268 3627059 R catalyses the following reaction: hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate; hydroxypyruvate isomerase complement(3626268..3627059) Arthrobacter arilaitensis Re117 9796814 YP_003918409.1 CDS AARI_32380 NC_014550.1 3627811 3629223 D Nucleobase:Cation Symporter-1 (NCS1) Family (TC 2.A. 39.y.z); hydantoin/allantoin permease 3627811..3629223 Arthrobacter arilaitensis Re117 9796815 YP_003918410.1 CDS hyuE NC_014550.1 3629233 3629979 D identified by similarity to protein SP:Q00924 (Pseudomonas sp. strain NS671). Match to protein family PF01177: Asp/Glu/Hydantoin racemase. Hydantoin racemase is responsible for racemization of the D-5-substituted hydantoins to their corresponding L-amino acids; hydantoin racemase 3629233..3629979 Arthrobacter arilaitensis Re117 9796816 YP_003918411.1 CDS AARI_32400 NC_014550.1 3630309 3630839 R hypothetical protein complement(3630309..3630839) Arthrobacter arilaitensis Re117 9793995 YP_003918412.1 CDS AARI_32410 NC_014550.1 3630883 3631194 R hypothetical protein complement(3630883..3631194) Arthrobacter arilaitensis Re117 9796817 YP_003918413.1 CDS AARI_32420 NC_014550.1 3631898 3632584 R hypothetical protein complement(3631898..3632584) Arthrobacter arilaitensis Re117 9796818 YP_003918414.1 CDS AARI_32430 NC_014550.1 3632761 3632982 D hypothetical protein 3632761..3632982 Arthrobacter arilaitensis Re117 9796819 YP_003918415.1 CDS AARI_32440 NC_014550.1 3632992 3633519 D hypothetical protein 3632992..3633519 Arthrobacter arilaitensis Re117 9796820 YP_003918416.1 CDS AARI_32450 NC_014550.1 3633813 3634799 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein 3633813..3634799 Arthrobacter arilaitensis Re117 9796821 YP_003918417.1 CDS AARI_32460 NC_014550.1 3634900 3635871 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit 3634900..3635871 Arthrobacter arilaitensis Re117 9796822 YP_003918418.1 CDS AARI_32470 NC_014550.1 3635876 3636910 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit 3635876..3636910 Arthrobacter arilaitensis Re117 9796823 YP_003918419.1 CDS AARI_32480 NC_014550.1 3636907 3637662 D TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, ATP-binding protein (ABC), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter ATP-binding subunit 3636907..3637662 Arthrobacter arilaitensis Re117 9796824 YP_003918420.1 CDS AARI_32490 NC_014550.1 3637712 3638113 D hypothetical protein 3637712..3638113 Arthrobacter arilaitensis Re117 9796825 YP_003918421.1 CDS AARI_32500 NC_014550.1 3638110 3639381 R match to protein family PF07690: Major Facilitator Superfamily; permease complement(3638110..3639381) Arthrobacter arilaitensis Re117 9796826 YP_003918422.1 CDS AARI_32510 NC_014550.1 3639745 3640527 R carbonate dehydratases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide. They are ubiquitous enzymes involved in fundamental processes like respiration, pH homeostasis and ion transport. Signal peptide predicted by SignalP 3.0 HMM (probability: 0.975) with cleavage site probability 0.621 between position 42 and 43; carbonate dehydratase complement(3639745..3640527) Arthrobacter arilaitensis Re117 9796827 YP_003918423.1 CDS AARI_32520 NC_014550.1 3640799 3641434 D identified by match to PF00440: bacterial regulatory proteins, tetR family; TetR family transcriptional regulator 3640799..3641434 Arthrobacter arilaitensis Re117 9796828 YP_003918424.1 CDS AARI_32530 NC_014550.1 3641439 3643043 D enzymes named acetyl-coenzyme A carboxylase (EC 6.4. 1.2), propionyl-coenzyme A carboxylase (EC 6.4.1.3) and acyl-coenzyme A carboxylase are constituted by several types of subunits. Alpha subunits contains the biotin carboxylase (BC, EC 6.3.4.14) and biotin carboxyl carrier protein (BCCP) domains, beta subunits contain the carboxyltransferase (CT) domain. An epsilon subunit is present in some microorganisms; acetyl-/propionyl-coenzyme A carboxylase subunit beta 3641439..3643043 Arthrobacter arilaitensis Re117 9796829 YP_003918425.1 CDS accA NC_014550.1 3643056 3645116 D enzymes named acetyl-coenzyme A carboxylase (EC 6.4. 1.2), propionyl-coenzyme A carboxylase (EC 6.4.1.3) and acyl-coenzyme A carboxylase are constituted by several types of subunits. Alpha subunits contains the biotin carboxylase (BC, EC 6.3.4.14) and biotin carboxyl carrier protein (BCCP) domains, beta subunits contain the carboxyltransferase (CT) domain. An epsilon subunit is present in some microorganisms; acetyl-/propionyl-coenzyme A carboxylase subunit alpha 3643056..3645116 Arthrobacter arilaitensis Re117 9796830 YP_003918426.1 CDS AARI_32550 NC_014550.1 3645113 3645637 D match to PF01575. Several bacterial proteins that are composed solely of this domain have (R)-specific enoyl- CoA hydratase activity; MaoC like domain-containing protein 3645113..3645637 Arthrobacter arilaitensis Re117 9793646 YP_003918427.1 CDS AARI_32560 NC_014550.1 3645645 3646430 D citrate lyase catalyses the formation of acetate and oxaloacetate from citrate; citrate lyase beta subunit 3645645..3646430 Arthrobacter arilaitensis Re117 9796831 YP_003918428.1 CDS AARI_32570 NC_014550.1 3646497 3647000 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3646497..3647000 Arthrobacter arilaitensis Re117 9796832 YP_003918429.1 CDS AARI_32590 NC_014550.1 3648498 3648782 D transcriptional regulator 3648498..3648782 Arthrobacter arilaitensis Re117 9796834 YP_003918430.1 CDS AARI_32600 NC_014550.1 3648821 3649189 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3648821..3649189) Arthrobacter arilaitensis Re117 9796835 YP_003918431.1 CDS AARI_32620 NC_014550.1 3649839 3651140 D major facilitator superfamily (TC 2.A.1.y.z). Identified by match to protein family PF07690; MFS superfamily transporter 3649839..3651140 Arthrobacter arilaitensis Re117 9796837 YP_003918432.1 CDS AARI_32630 NC_014550.1 3651234 3651671 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3651234..3651671) Arthrobacter arilaitensis Re117 9796838 YP_003918433.1 CDS AARI_32640 NC_014550.1 3652785 3653015 R hypothetical protein complement(3652785..3653015) Arthrobacter arilaitensis Re117 9796920 YP_003918434.1 CDS AARI_36200 NC_014550.1 3653726 3655033 R transposase of ISAar20, ISL3 family complement(3653726..3655033) Arthrobacter arilaitensis Re117 9793557 YP_003918435.1 CDS AARI_32650 NC_014550.1 3656139 3656399 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3656139..3656399 Arthrobacter arilaitensis Re117 9793558 YP_003918436.1 CDS AARI_36210 NC_014550.1 3656660 3658105 R transposase of ISAar22, IS481 family complement(3656660..3658105) Arthrobacter arilaitensis Re117 9796922 YP_003918437.1 CDS AARI_32660 NC_014550.1 3658625 3659080 R 4 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3658625..3659080) Arthrobacter arilaitensis Re117 9793559 YP_003918438.1 CDS AARI_32670 NC_014550.1 3659202 3659531 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3659202..3659531) Arthrobacter arilaitensis Re117 9796923 YP_003918439.1 CDS AARI_32680 NC_014550.1 3659531 3659914 R 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3659531..3659914) Arthrobacter arilaitensis Re117 9796924 YP_003918440.1 CDS AARI_32690 NC_014550.1 3660064 3661110 D identified by match to PF00753: metallo-beta- lactamase superfamily. Apart from the beta-lactamases, a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake; metallo-beta-lactamase 3660064..3661110 Arthrobacter arilaitensis Re117 9796925 YP_003918441.1 CDS AARI_32720 NC_014550.1 3662491 3663417 R identified by match to PF00126: bacterial regulatory helix-turn-helix protein, lysR family. Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI. The majority of these proteins appear to be transcription activators and most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini; LysR family transcriptional regulator complement(3662491..3663417) Arthrobacter arilaitensis Re117 9796928 YP_003918442.1 CDS AARI_32730 NC_014550.1 3663449 3663736 R hypothetical protein complement(3663449..3663736) Arthrobacter arilaitensis Re117 9796929 YP_003918443.1 CDS AARI_32740 NC_014550.1 3663843 3665072 R possibly involved in the metabolism of lipids. Match to PF08028. Acyl-CoA dehydrogenases catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase complement(3663843..3665072) Arthrobacter arilaitensis Re117 9796930 YP_003918444.1 CDS AARI_32750 NC_014550.1 3665101 3666312 R possibly involved in the metabolism of lipids. Match to PF08028, PF02770 and PF02771. Acyl-CoA dehydrogenases catalyze the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with concommitant reduction of enzyme-bound FAD; acyl-CoA dehydrogenase complement(3665101..3666312) Arthrobacter arilaitensis Re117 9796931 YP_003918445.1 CDS AARI_32760 NC_014550.1 3666579 3667631 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(3666579..3667631) Arthrobacter arilaitensis Re117 9796932 YP_003918446.1 CDS AARI_32770 NC_014550.1 3667618 3668667 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, permease (IM), ISVH-family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter inner membrane subunit complement(3667618..3668667) Arthrobacter arilaitensis Re117 9796933 YP_003918447.1 CDS AARI_32780 NC_014550.1 3668669 3669523 R identified by match to protein family PF04954. Match to protein domain PF08021. Possibly involved in removal of iron from iron-siderophore complexes; siderophore-interacting protein complement(3668669..3669523) Arthrobacter arilaitensis Re117 9796934 YP_003918448.1 CDS AARI_32790 NC_014550.1 3669548 3670552 R TCDB: ATP-binding cassette (ABC) superfamily, iron chelate uptake transporter (FeCT) family (TC 3.A.1.14.z). ABCISSE: ABC transporter, binding protein (BP), ISVH- family (iron siderophores, vitamin B12 and hemin); iron-siderophore ABC transporter substrate-binding protein complement(3669548..3670552) Arthrobacter arilaitensis Re117 9796935 YP_003918449.1 CDS AARI_32800 NC_014550.1 3670735 3671505 D identified by match to PF01648: 4- phosphopantetheinyl transferase superfamily. Holo-[acyl- carrier-protein] synthase catalyses the following reaction: CoA-(4-phosphopantetheine) + apo-[acyl-carrier- protein] => adenosine 3,5-bisphosphate + holo-[acyl- carrier-protein]. All polyketide synthases, fatty-acid synthases and non-ribosomal peptide synthases require post- translational modification of their constituent acyl- carrier-protein (ACP) domains to become catalytically active. The inactive apo-proteins are converted into their active holo-forms by transfer of the 4-phosphopantetheinyl moiety of CoA to the sidechain hydroxy group of a conserved serine residue in each ACP domain; non-ribosomal peptide synthase accessory protein 3670735..3671505 Arthrobacter arilaitensis Re117 9796936 YP_003918450.1 CDS AARI_32810 NC_014550.1 3671528 3672880 R Major Facilitator Superfamily (MFS), Enterobactin (Siderophore) Exporter (EntS) Family (TC 2.A.1.38.z); siderophore exporter complement(3671528..3672880) Arthrobacter arilaitensis Re117 9796937 YP_003918451.1 CDS AARI_32820 NC_014550.1 3672877 3673071 R identified by match to protein domain PF03621. This domain is found in the MbtH protein O05821 (probably involved in mycobactin synthesis) as well as at the N terminus of the antibiotic synthesis protein NIKP1. Many of the members of this family are found in known antibiotic synthesis gene clusters. Possible involvement in the synthesis of siderophore group non-ribosomal peptides; MbtH-like protein complement(3672877..3673071) Arthrobacter arilaitensis Re117 9796938 YP_003918452.1 CDS AARI_32830 NC_014550.1 3673121 3677149 R non-ribosomal siderophore peptide synthetase component complement(3673121..3677149) Arthrobacter arilaitensis Re117 9796939 YP_003918453.1 CDS AARI_32840 NC_014550.1 3677149 3683670 R non-ribosomal siderophore peptide synthetase component complement(3677149..3683670) Arthrobacter arilaitensis Re117 9796940 YP_003918454.1 CDS AARI_32850 NC_014550.1 3683770 3685194 R non-ribosomal siderophore peptide synthetase component complement(3683770..3685194) Arthrobacter arilaitensis Re117 9796941 YP_003918455.1 CDS AARI_32860 NC_014550.1 3685277 3688540 R non-ribosomal siderophore peptide synthetase component complement(3685277..3688540) Arthrobacter arilaitensis Re117 9796942 YP_003918456.1 CDS AARI_32870 NC_014550.1 3688579 3688824 R non-ribosomal siderophore peptide synthetase component complement(3688579..3688824) Arthrobacter arilaitensis Re117 9796943 YP_003918457.1 CDS AARI_32880 NC_014550.1 3688821 3690161 R L-ornithine 5-monooxygenase catalyzes the conversion of L-ornithine into N5-hydroxy-L-ornithine, which is later incorporated in the siderophore pyoverdin, produced by Pseudomonas aeruginosa; L-ornithine 5-monooxygenase complement(3688821..3690161) Arthrobacter arilaitensis Re117 9796944 YP_003918458.1 CDS AARI_32890 NC_014550.1 3690158 3691807 R similar to enterobactin synthase subunit E, which includes (2,3-dihydroxybenzoyl)adenylate synthase activity (EC 2.7.7.58); non-ribosomal siderophore peptide synthetase component complement(3690158..3691807) Arthrobacter arilaitensis Re117 9796945 YP_003918459.1 CDS dhbC NC_014550.1 3691804 3692985 R plays a role in the siderophore biosynthesis and in the bacillibactin biosynthesis; isochorismate synthase complement(3691804..3692985) Arthrobacter arilaitensis Re117 9796946 YP_003918460.1 CDS dhbA NC_014550.1 3693038 3693796 R involved in the third stage of enterobactin (siderophore peptide) biosynthesis, the conversion of 2,3- dihydro-2,3-dihydroxybenzoate into 2,3-dihydroxybenzoate; 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase complement(3693038..3693796) Arthrobacter arilaitensis Re117 9793813 YP_003918461.1 CDS dhbB NC_014550.1 3693793 3694449 R involved in the second stage of enterobactin (siderophore peptide) biosynthesis, the conversion of isochorismate into 2,3-dihydroxy-2,3-dihydrobenzoate; isochorismatase complement(3693793..3694449) Arthrobacter arilaitensis Re117 9793811 YP_003918462.1 CDS AARI_32930 NC_014550.1 3695142 3696065 D signal peptide predicted by SignalP 3.0 HMM (probability: 1.000) with cleavage site probability 0.995 between position 30 and 31; hypothetical protein 3695142..3696065 Arthrobacter arilaitensis Re117 9793812 YP_003918463.1 CDS AARI_32950 NC_014550.1 3696394 3697227 R identified by similarity to protein SP:O31168 (Streptomyces aureofaciens). Catalyzes the following reaction: 2 RH + 2 Cl(-) + H(2)O(2) <=> 2 RCl + 2 H(2)O. Brings about the chlorination of a range of organic molecules, forming stable C-Cl bonds; chloride peroxidase complement(3696394..3697227) Arthrobacter arilaitensis Re117 9796948 YP_003918464.1 CDS AARI_32960 NC_014550.1 3697336 3697611 R hypothetical protein complement(3697336..3697611) Arthrobacter arilaitensis Re117 9796949 YP_003918465.1 CDS AARI_32970 NC_014550.1 3697615 3698976 R Gluconate:H+ Symporter (GntP) Family (TC 2.A.8.y.z). Match to protein family PF02447; gluconate permease complement(3697615..3698976) Arthrobacter arilaitensis Re117 9796950 YP_003918466.1 CDS AARI_32980 NC_014550.1 3699269 3700330 R match to protein domain PF05651: sugar diacid recognition; hypothetical protein complement(3699269..3700330) Arthrobacter arilaitensis Re117 9796951 YP_003918467.1 CDS AARI_32990 NC_014550.1 3700457 3700639 D hypothetical protein 3700457..3700639 Arthrobacter arilaitensis Re117 9796952 YP_003918468.1 CDS AARI_33000 NC_014550.1 3700726 3701274 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.994) with cleavage site probability 0.846 between position 30 and 31; hypothetical protein complement(3700726..3701274) Arthrobacter arilaitensis Re117 9796953 YP_003918469.1 CDS glxK NC_014550.1 3702230 3703408 R catalyses the following reaction: ATP + (R)- glycerate <=> ADP + 3-phospho-(R)-glycerate; glycerate kinase complement(3702230..3703408) Arthrobacter arilaitensis Re117 9796956 YP_003918470.1 CDS AARI_33040 NC_014550.1 3704444 3704914 D hypothetical protein 3704444..3704914 Arthrobacter arilaitensis Re117 9793925 YP_003918471.1 CDS AARI_33050 NC_014550.1 3705074 3706564 D Sulfate Permease (SulP) Family, sulfate permease (TC 2.A.53.3.1); sulfate permease 3705074..3706564 Arthrobacter arilaitensis Re117 9796957 YP_003918472.1 CDS AARI_36220 NC_014550.1 3706570 3707529 R transposase of ISAar35, IS481 family complement(3706570..3707529) Arthrobacter arilaitensis Re117 9796958 YP_003918473.1 CDS AARI_33060 NC_014550.1 3707672 3709279 R activates fatty acids by binding to coenzyme A. Possibly involved in the synthesis of cellular lipids or their degradation via beta-oxidation; fatty-acid--CoA ligase complement(3707672..3709279) Arthrobacter arilaitensis Re117 9793560 YP_003918474.1 CDS catR NC_014550.1 3709660 3710586 D possibly involved in the regulation of the catechol catabolism.Match to PF00126: bacterial regulatory helix- turn-helix protein, lysR family; transcriptional regulator CatR 3709660..3710586 Arthrobacter arilaitensis Re117 9796959 YP_003918475.1 CDS catB NC_014550.1 3710567 3711688 D identified by similarity to protein SP:Q76CC6 (Arthrobacter sp.). Involved in the degradation of aromatic compounds by converting cis,cis-muconate, the product of catechol ring cleavage to (4S)-muconolactone; muconate cycloisomerase 3710567..3711688 Arthrobacter arilaitensis Re117 9793731 YP_003918476.1 CDS catC NC_014550.1 3711701 3711979 D catalyses the third step in the catabolism of catechol to succinyl-CoA and acetyl-CoA in the beta- ketoadipate pathway; muconolactone Delta-isomerase 3711701..3711979 Arthrobacter arilaitensis Re117 9793729 YP_003918477.1 CDS catA NC_014550.1 3712173 3713030 D catalyses the third step in the catabolism of catechol to succinyl-CoA and acetyl-CoA in the beta- ketoadipate pathway: the intradiol cleavage reaction of catechol to form cis,cis-muconate; catechol 1,2-dioxygenase 3712173..3713030 Arthrobacter arilaitensis Re117 9793730 YP_003918478.1 CDS AARI_33110 NC_014550.1 3713134 3713634 D signal peptide predicted by SignalP 3.0 HMM (probability: 0.966) with cleavage site probability 0.717 between position 31 and 32. 3 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein 3713134..3713634 Arthrobacter arilaitensis Re117 9793728 YP_003918479.1 CDS AARI_33120 NC_014550.1 3713779 3715338 D identified by match to cd00085: HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins; HNH endonuclease domain-containing protein 3713779..3715338 Arthrobacter arilaitensis Re117 9796960 YP_003918480.1 CDS cmr NC_014550.1 3716847 3718265 D major facilitator superfamily (MFS), drug:H+ antiporter-3 (12 spanner) (DHA3) family, multidrug (erythromycin, tetracycline, puromycin, bleomycin) resistance protein Cmr (TC 2.A.1.21.2). Identified by similarity to protein SP:Q79VC7 (Corynebacterium glutamicum). Probable drug antiporter which uses the proton motive force for the active efflux drugs; multidrug resistance protein 3716847..3718265 Arthrobacter arilaitensis Re117 9796964 YP_003918481.1 CDS AARI_33180 NC_014550.1 3718684 3719094 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.976) with cleavage site probability 0.942 between position 24 and 25. 3 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(3718684..3719094) Arthrobacter arilaitensis Re117 9796965 YP_003918482.1 CDS AARI_33190 NC_014550.1 3719207 3720316 R hypothetical protein complement(3719207..3720316) Arthrobacter arilaitensis Re117 9796966 YP_003918483.1 CDS fixA NC_014550.1 3720720 3721496 D electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, (housekeeping) ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II). They consist of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit; electron transfer flavoprotein subunit beta 3720720..3721496 Arthrobacter arilaitensis Re117 9796967 YP_003918484.1 CDS fixB NC_014550.1 3721493 3722491 D electron transfer flavoproteins (ETFs) serve as specific electron acceptors for primary dehydrogenases, transferring the electrons to terminal respiratory systems. They can be functionally classified into constitutive, (housekeeping) ETFs, mainly involved in the oxidation of fatty acids (Group I), and ETFs produced by some prokaryotes under specific growth conditions, receiving electrons only from the oxidation of specific substrates (Group II). They consist of three domains: domains I and II are formed by the N- and C-terminal portions of the alpha subunit, respectively, while domain III is formed by the beta subunit; electron transfer flavoprotein subunit alpha 3721493..3722491 Arthrobacter arilaitensis Re117 9793852 YP_003918485.1 CDS AARI_33220 NC_014550.1 3722497 3724410 D 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3722497..3724410 Arthrobacter arilaitensis Re117 9793854 YP_003918486.1 CDS AARI_33230 NC_014550.1 3724513 3725181 D identified by match to protein domain PF08241; SAM-dependent methyltransferase 3724513..3725181 Arthrobacter arilaitensis Re117 9796968 YP_003918487.1 CDS AARI_33250 NC_014550.1 3725558 3727348 R hypothetical protein complement(3725558..3727348) Arthrobacter arilaitensis Re117 9796970 YP_003918488.1 CDS AARI_33260 NC_014550.1 3727565 3728188 D hypothetical protein 3727565..3728188 Arthrobacter arilaitensis Re117 9796971 YP_003918489.1 CDS AARI_33270 NC_014550.1 3728279 3728977 D hypothetical protein 3728279..3728977 Arthrobacter arilaitensis Re117 9796972 YP_003918490.1 CDS AARI_33280 NC_014550.1 3729072 3730121 D match to PF02492 (CobW/HypB/UreG, nucleotide- binding domain) and PF07683 (Cobalamin synthesis protein cobW C-terminal domain). In Pseudomonas denitrificans, the cobW gene product may be involved in cobalamin biosynthesis; cobalamin biosynthesis protein 3729072..3730121 Arthrobacter arilaitensis Re117 9796973 YP_003918491.1 CDS AARI_33290 NC_014550.1 3730150 3730341 R 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3730150..3730341) Arthrobacter arilaitensis Re117 9796974 YP_003918492.1 CDS AARI_36230 NC_014550.1 3730937 3732016 D transposase of ISAar29, IS110 family 3730937..3732016 Arthrobacter arilaitensis Re117 9796975 YP_003918493.1 CDS AARI_36240 NC_014550.1 3732631 3733932 R transposase of ISAar34, ISL3 family complement(3732631..3733932) Arthrobacter arilaitensis Re117 9793561 YP_003918494.1 CDS hsdR NC_014550.1 3734102 3737563 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system restriction subunit complement(3734102..3737563) Arthrobacter arilaitensis Re117 9793562 YP_003918495.1 CDS AARI_33310 NC_014550.1 3738097 3739311 R identified by match to PF02661: Fic protein family. cAMP may be a regulation factor in cell division of some bacteria. The Fic (filamentation induced by cAMP) protein is involved in the synthesis of PAB or folate. It would appear that the Fic protein and cAMP are involved in a regulatory mechanism of cell division via folate metabolism and in these organisms cell division could be controlled by coordination of cAMP, Fic and Fts proteins; Fic family protein complement(3738097..3739311) Arthrobacter arilaitensis Re117 9793982 YP_003918496.1 CDS mrr NC_014550.1 3739594 3740523 R identified by match to PF04471. Mrr is involved in the acceptance of foreign DNA which is modified. Restricts both adenine- and cytosine-methylated DNA; restriction system protein Mrr complement(3739594..3740523) Arthrobacter arilaitensis Re117 9796976 YP_003918497.1 CDS hsdS NC_014550.1 3740523 3741704 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system specificity subunit complement(3740523..3741704) Arthrobacter arilaitensis Re117 9794108 YP_003918498.1 CDS hsdM NC_014550.1 3741701 3743221 R type I restriction endonucleases are components of prokaryotic DNA restriction-modification mechanisms that protects the organism against invading foreign DNA. They have three different subunits: subunits - M (modification), S (specificity) and R (restriction) - that form multifunctional enzymes with restriction (EC:3.1.21.3), methylase (EC:2.1.1.72) and ATPase activities. The S subunit is required for both restriction and modification and is responsible for recognition of the DNA sequence specific for the system. The M subunit is necessary for modification, and the R subunit is required for restriction. They recognize asymmetric DNA sequences split into two domains of specific sequence, one 3-4 bp long and another 4-5 bp long, separated by a nonspecific spacer 6-8 bp in length. Cleavage occurs a considerable distance from the recognition sites, rarely less than 400 bp away and up to 7000 bp away. Adenosyl residues are methylated, one on each strand of the recognition sequence; type I restriction-modification system modification subunit complement(3741701..3743221) Arthrobacter arilaitensis Re117 9793985 YP_003918499.1 CDS AARI_33350 NC_014550.1 3743890 3745656 R hypothetical protein complement(3743890..3745656) Arthrobacter arilaitensis Re117 9793980 YP_003918500.1 CDS AARI_33360 NC_014550.1 3745798 3747246 D hypothetical protein 3745798..3747246 Arthrobacter arilaitensis Re117 9796977 YP_003918501.1 CDS AARI_33370 NC_014550.1 3747243 3747923 D hypothetical protein 3747243..3747923 Arthrobacter arilaitensis Re117 9796978 YP_003918502.1 CDS AARI_33400 NC_014550.1 3751298 3752446 D hypothetical protein 3751298..3752446 Arthrobacter arilaitensis Re117 9796981 YP_003918503.1 CDS AARI_33410 NC_014550.1 3753374 3754210 R presence of 2 conserved barrel domains of the cupin superfamily (PF07883); barrel domain-containing protein complement(3753374..3754210) Arthrobacter arilaitensis Re117 9796982 YP_003918504.1 CDS AARI_33420 NC_014550.1 3754221 3755474 R hypothetical protein complement(3754221..3755474) Arthrobacter arilaitensis Re117 9796983 YP_003918505.1 CDS AARI_33430 NC_014550.1 3755471 3757102 R catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate, the second step of the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants; malate synthase complement(3755471..3757102) Arthrobacter arilaitensis Re117 9796984 YP_003918506.1 CDS AARI_33440 NC_014550.1 3757181 3758566 R catalyzes the oxidative decarboxylation of malate into pyruvate. Uses preferentially NAD and has the ability to decarboxylate oxaloacetate; malate dehydrogenase (oxaloacetate-decarboxylating) complement(3757181..3758566) Arthrobacter arilaitensis Re117 9796985 YP_003918507.1 CDS AARI_33450 NC_014550.1 3758785 3759558 D this family of bacterial transcriptional regulators groups several proteins, including gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces, and iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium; IclR family transcriptional regulator 3758785..3759558 Arthrobacter arilaitensis Re117 9796986 YP_003918508.1 CDS AARI_33460 NC_014550.1 3759571 3761424 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC), DPL-family, prokaryote drug export (PED) subfamily. Possible function in in antibiotic peptide or drug resistance or production (export); drug resistance ATP-binding protein complement(3759571..3761424) Arthrobacter arilaitensis Re117 9796987 YP_003918509.1 CDS AARI_33470 NC_014550.1 3761698 3762294 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(3761698..3762294) Arthrobacter arilaitensis Re117 9796988 YP_003918510.1 CDS AARI_33480 NC_014550.1 3762488 3763519 D identified by match to PF00248 family: Aldo/keto reductase family. This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity; aldo-keto reductase family protein 3762488..3763519 Arthrobacter arilaitensis Re117 9796989 YP_003918511.1 CDS AARI_33490 NC_014550.1 3763595 3764389 D identified by match to protein family PF00795. This family contains nitrilases that break carbon-nitrogen bonds and appear to be involved in the reduction of organic nitrogen compounds and ammonia production. They all have distinct substrate specificity and include cyanide hydratases, aliphatic amidases, beta-alanine synthase, and a few other proteins with unknown molecular function; carbon-nitrogen hydrolase 3763595..3764389 Arthrobacter arilaitensis Re117 9796990 YP_003918512.1 CDS AARI_33520 NC_014550.1 3765404 3766429 D identified by match to PF01408 (oxidoreductase family, NAD-binding Rossmann fold); oxidoreductase domain-containing protein 3765404..3766429 Arthrobacter arilaitensis Re117 9796993 YP_003918513.1 CDS galE NC_014550.1 3766472 3767431 R catalyses the formation of UDP-glucose from UDP- galactose. Involved in the catabolism of galactose; UDP-glucose 4-epimerase complement(3766472..3767431) Arthrobacter arilaitensis Re117 9796994 YP_003918514.1 CDS galK NC_014550.1 3767428 3768624 R catalyzes the conversion of galactose to galactose 1-phosphate, first step of the Leloir pathway; galactokinase complement(3767428..3768624) Arthrobacter arilaitensis Re117 9793880 YP_003918515.1 CDS galT NC_014550.1 3768621 3769736 R involved in conversion of galactose into alpha-D- glucose 1-phosphate, second step of the Leloir pathway; UDP-glucose--hexose-1-phosphate uridylyltransferase complement(3768621..3769736) Arthrobacter arilaitensis Re117 9793881 YP_003918516.1 CDS AARI_33560 NC_014550.1 3769733 3770524 R DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-like regulators are generally phosphorylated intermediates of the relevant metabolic pathway; DeoR family transcriptional regulator complement(3769733..3770524) Arthrobacter arilaitensis Re117 9793882 YP_003918517.1 CDS AARI_33570 NC_014550.1 3770813 3771415 R match to PF00440: bacterial regulatory proteins, tetR family; transcriptional regulator complement(3770813..3771415) Arthrobacter arilaitensis Re117 9796995 YP_003918518.1 CDS AARI_33580 NC_014550.1 3771597 3772937 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, binding protein (BP), OSP-family (oligosaccharides or polyols); lactose ABC transporter substrate-binding protein 3771597..3772937 Arthrobacter arilaitensis Re117 9796996 YP_003918519.1 CDS AARI_33590 NC_014550.1 3772934 3773866 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, permease (IM), OSP- family (oligosaccharides or polyols); lactose ABC transporter inner membrane subunit 3772934..3773866 Arthrobacter arilaitensis Re117 9796997 YP_003918520.1 CDS AARI_33600 NC_014550.1 3773863 3774738 D TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-1 (CUT1) family (TC 3.A.1. 1.z). ABCISSE: ABC transporter, permease (IM), OSP- family (oligosaccharides or polyols); lactose ABC transporter inner membrane subunit 3773863..3774738 Arthrobacter arilaitensis Re117 9796998 YP_003918521.1 CDS lacZ NC_014550.1 3774735 3777863 D hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides. Some enzymes in this group hydrolyze alpha-L-arabinosides; beta-galactosidase 3774735..3777863 Arthrobacter arilaitensis Re117 9796999 YP_003918522.1 CDS AARI_33620 NC_014550.1 3777885 3778868 R identified by match to protein family PF1263. Aldose 1-epimerase (mutarotase) is the enzyme responsible for the anomeric interconversion of D-glucose and other aldoses (L-arabinose, D-xylose, D-galactose, maltose and lactose) between their alpha- and beta-forms; aldose 1-epimerase complement(3777885..3778868) Arthrobacter arilaitensis Re117 9794028 YP_003918523.1 CDS AARI_33630 NC_014550.1 3778922 3780103 R TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, permease (IM), MOS-family (monosaccharides: pentoses and hexoses). Possibly involved in the uptake of multiple sugars such as arabinose, xylose, galactose, glucose, fucose; multiple sugar ABC transporter inner membrane subunit complement(3778922..3780103) Arthrobacter arilaitensis Re117 9797000 YP_003918524.1 CDS AARI_33640 NC_014550.1 3780100 3781638 R TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, fused ATP- binding protein (ABC2), MOS-family (monosaccharides: pentoses and hexoses). Possibly involved in the uptake of multiple sugars such as arabinose, xylose, galactose, glucose, fucose; multiple sugar ABC transporter ATP-binding subunit complement(3780100..3781638) Arthrobacter arilaitensis Re117 9797082 YP_003918525.1 CDS AARI_33650 NC_014550.1 3781727 3782896 R TCDB: ATP-binding cassette (ABC) superfamily, carbohydrate uptake transporter-2 (CUT2) family (TC 3.A.1. 2.z). ABCISSE: ABCISSE: ABC transporter, binding protein (BP), MOS-family (monosaccharides: pentoses and hexoses). Possibly involved in the uptake of multiple sugars such as arabinose, xylose, galactose, glucose, fucose; multiple sugar ABC transporter substrate-binding protein complement(3781727..3782896) Arthrobacter arilaitensis Re117 9797083 YP_003918526.1 CDS araA NC_014550.1 3783072 3784583 R catalyzes the isomerization of L-arabinose to L- ribulose, the first reaction in its conversion into D- xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon source; L-arabinose isomerase complement(3783072..3784583) Arthrobacter arilaitensis Re117 9797084 YP_003918527.1 CDS araD NC_014550.1 3784591 3785307 R catalyses the following reaction: L-ribulose 5- phosphate <=> D-xylulose 5-phosphate. Involved in the metabolism of L-arabinose; L-ribulose-5-phosphate 4-epimerase complement(3784591..3785307) Arthrobacter arilaitensis Re117 9793669 YP_003918528.1 CDS araB NC_014550.1 3785333 3786946 R catalyzes the formation of L-ribulose 5-phosphate from L-ribulose. Involved in the catabolism of L- arabinose. Match to protein domain PF00370: FGGY family of carbohydrate kinases, N-terminal domain; ribulokinase complement(3785333..3786946) Arthrobacter arilaitensis Re117 9793671 YP_003918529.1 CDS AARI_33690 NC_014550.1 3787116 3788171 R match to protein domain PF00356. Numerous bacterial transcription regulatory proteins bind DNA via a helix- turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family groups together a range of proteins, including ascG, ccpA, cytR, ebgR, fruR, galR, galS, lacI, malI, opnR, purF, rafR, rbtR and scrR. Within this family, the HTH motif is situated towards the N-terminus; LacI family transcriptional regulator complement(3787116..3788171) Arthrobacter arilaitensis Re117 9793670 YP_003918530.1 CDS AARI_33700 NC_014550.1 3788428 3789915 R nucleobase:cation symporter-2 (NCS2) Family (TC 2.A. 40.y.z). Match to protein family PF00860; xanthine/uric acid permease complement(3788428..3789915) Arthrobacter arilaitensis Re117 9797085 YP_003918531.1 CDS AARI_33710 NC_014550.1 3790039 3790962 R catalyses the formation of 5-hydroxyisourate from urate. The latter decomposes spontaneously to form allantoin; urate oxidase complement(3790039..3790962) Arthrobacter arilaitensis Re117 9797086 YP_003918532.1 CDS AARI_33720 NC_014550.1 3790966 3791322 R identified by match to PF00576: HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to 5-hydroxy-2-oxo-4- ureido-2,5-dihydro-1H-imidazole-5- carboxylate (OHCU). HIU hydrolysis is the original function of the family and is conserved from bacteria to mammals; transthyretins arose by gene duplications in the vertebrate lineage; hydroxyisourate hydrolase complement(3790966..3791322) Arthrobacter arilaitensis Re117 9797087 YP_003918533.1 CDS AARI_33730 NC_014550.1 3791386 3791880 R hypothetical protein complement(3791386..3791880) Arthrobacter arilaitensis Re117 9797088 YP_003918534.1 CDS AARI_33740 NC_014550.1 3792205 3792399 D hypothetical protein 3792205..3792399 Arthrobacter arilaitensis Re117 9797089 YP_003918535.1 CDS AARI_33750 NC_014550.1 3792471 3792767 R hypothetical protein complement(3792471..3792767) Arthrobacter arilaitensis Re117 9797090 YP_003918536.1 CDS AARI_33760 NC_014550.1 3792771 3793106 R hypothetical protein complement(3792771..3793106) Arthrobacter arilaitensis Re117 9797091 YP_003918537.1 CDS AARI_33770 NC_014550.1 3793214 3794230 R Auxin Efflux Carrier (AEC) Family (TC 2.A.69.y.z). Homologues of the AEC family are found in bacteria as well as in archaea. The K. pneumoniae homologues has been implicated in malonate uptake, the O. oeni homologue is a malate permease; RHBT family transporter complement(3793214..3794230) Arthrobacter arilaitensis Re117 9797092 YP_003918538.1 CDS AARI_33780 NC_014550.1 3794428 3795192 D identified by match to PF00106. The short-chain dehydrogenases/reductases family (SDR) is a very large family of enzymes, most of which are known to be NAD- or NADP-dependent oxidoreductases; short-chain dehydrogenases/reductases family protein 3794428..3795192 Arthrobacter arilaitensis Re117 9797093 YP_003918539.1 CDS AARI_33800 NC_014550.1 3795611 3796060 R hypothetical protein complement(3795611..3796060) Arthrobacter arilaitensis Re117 9797095 YP_003918540.1 CDS AARI_33810 NC_014550.1 3796108 3796365 R hypothetical protein complement(3796108..3796365) Arthrobacter arilaitensis Re117 9797096 YP_003918541.1 CDS AARI_33820 NC_014550.1 3796453 3796914 R identified by match to protein family PF01047. Regulators with the marR-type HTH domain are present in bacteria and archaea and control a variety of biological functions, including resistance to multiple antibiotics, household disinfectants, organic solvents, oxidative stress agents and regulation of the virulence factor synthesis in pathogens of humans and plants. Many of the marR-like regulators respond to aromatic compounds; MarR family transcriptional regulator complement(3796453..3796914) Arthrobacter arilaitensis Re117 9797097 YP_003918542.1 CDS AARI_33830 NC_014550.1 3797038 3798039 D identified by match to PF02678. Pirin was identified to be a metal-binding protein, and it was found that the metal-binding residues of Pirins are highly conserved across mammals, plants, fungi, and prokaryotic organisms; pirin-like protein 3797038..3798039 Arthrobacter arilaitensis Re117 9797098 YP_003918543.1 CDS AARI_33840 NC_014550.1 3798057 3798389 D identified by match to PF00583: acetyltransferase (GNAT) family; GNAT family acetyltransferase 3798057..3798389 Arthrobacter arilaitensis Re117 9797099 YP_003918544.1 CDS AARI_33850 NC_014550.1 3798386 3799768 R major facilitator superfamily, drug:H+ antiporter-2 (14 spanner) (DHA2) family (TC 2.A.1.3.z). Match to PR01036: Tetracycline resistance protein TetB signature; multidrug resistance efflux protein complement(3798386..3799768) Arthrobacter arilaitensis Re117 9797100 YP_003918545.1 CDS AARI_33870 NC_014550.1 3800171 3801574 D match to protein family PF00929. This family includes a variety of exonuclease proteins, such as ribonuclease T and the epsilon subunit of DNA polymerase III; exonuclease 3800171..3801574 Arthrobacter arilaitensis Re117 9797102 YP_003918546.1 CDS AARI_33880 NC_014550.1 3801695 3802438 R signal peptide predicted by SignalP 3.0 HMM (probability: 0.832) with cleavage site probability 0.394 between position 23 and 24. 7 transmembrane helices predicted by TMHMM2.0 after the signal peptide; hypothetical protein complement(3801695..3802438) Arthrobacter arilaitensis Re117 9797103 YP_003918547.1 CDS dnaB NC_014550.1 3802501 3803856 R a homohexameric protein required for DNA replication. The homohexamer can form a ring around a single strand of DNA near a replication fork. DnaB is a DNA helicase which exhibits DNA-dependent ATPase activity; replicative DNA helicase complement(3802501..3803856) Arthrobacter arilaitensis Re117 9797104 YP_003918548.1 CDS AARI_33900 NC_014550.1 3804512 3805012 R identified by match to PF01613; flavin reductase-like domain protein complement(3804512..3805012) Arthrobacter arilaitensis Re117 9793821 YP_003918549.1 CDS AARI_33910 NC_014550.1 3805597 3807204 D match to protein family PF00501. This family of enzymes includes luciferase, long chain fatty acid Co-A ligase, acetyl-CoA synthetase and various other closely- related synthetases; fatty acid--Co-A ligase 3805597..3807204 Arthrobacter arilaitensis Re117 9797105 YP_003918550.1 CDS AARI_33920 NC_014550.1 3807220 3807636 D match to protein domain PF03061: thioesterase superfamily; thioesterase family domain-containing protein 3807220..3807636 Arthrobacter arilaitensis Re117 9797106 YP_003918551.1 CDS AARI_33930 NC_014550.1 3808378 3808674 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3808378..3808674 Arthrobacter arilaitensis Re117 9797107 YP_003918552.1 CDS AARI_33940 NC_014550.1 3808871 3809149 D 3 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3808871..3809149 Arthrobacter arilaitensis Re117 9797108 YP_003918553.1 CDS AARI_33950 NC_014550.1 3809244 3809834 D match to protein domain PF01872. This domain is found in the C-terminus of the bifunctional deaminase- reductase in combination with PF00383 as well as in isolation in some archaebacterial proteins; RibD domain-containing protein 3809244..3809834 Arthrobacter arilaitensis Re117 9797109 YP_003918554.1 CDS AARI_33960 NC_014550.1 3809842 3810900 D identified by match to PF07995. Proteins containing this domain are thought to be glucose/sorbosone dehydrogenases. Quinoprotein glucose dehydrogenase catalyses the following reaction: D-glucose + ubiquinone => D-glucono-1,5-lactone + ubiquinol. It is a PQQ- containing quinoprotein that catalyzes a direct oxidation of D-glucose to D-gluconate in the periplasm of some bacteria and concomitantly transfers electrons to ubiquinol oxidase through ubiquinone in the respiratory chain. Signal peptide predicted by SignalP 3.0 HMM (probability: 0.982) with cleavage site probability 0.254 between position 48 and 49; quinoprotein glucose dehydrogenase 3809842..3810900 Arthrobacter arilaitensis Re117 9797110 YP_003918555.1 CDS cat1 NC_014550.1 3810995 3812512 R identified by similarity to protein SP:P38946 (Clostridium kluyveri). Succinyl-CoA:coenzyme A transferase forms succinyl-CoA from succinate and acetyl- CoA and is believed to be involved in anaerobic succinate degradation; succinyl-CoA:coenzyme A transferase complement(3810995..3812512) Arthrobacter arilaitensis Re117 9797111 YP_003918556.1 CDS AARI_33980 NC_014550.1 3812727 3813032 R match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein complement(3812727..3813032) Arthrobacter arilaitensis Re117 9793727 YP_003918557.1 CDS rplI NC_014550.1 3813318 3813776 R binds to the 23S rRNA; 50S ribosomal protein L9 complement(3813318..3813776) Arthrobacter arilaitensis Re117 9797112 YP_003918558.1 CDS rpsR NC_014550.1 3813797 3814036 R part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6; 30S ribosomal protein S18 complement(3813797..3814036) Arthrobacter arilaitensis Re117 9794316 YP_003918559.1 CDS ssb NC_014550.1 3814098 3814667 R this protein is essential for replication of the chromosome. It is also involved in DNA recombination and repair; single-stranded DNA-binding protein complement(3814098..3814667) Arthrobacter arilaitensis Re117 9794365 YP_003918560.1 CDS rpsF NC_014550.1 3814723 3815019 R binds together with S18 to 16S ribosomal RNA; 30S ribosomal protein S6 complement(3814723..3815019) Arthrobacter arilaitensis Re117 9794405 YP_003918561.1 CDS AARI_34030 NC_014550.1 3815191 3817278 R match to protein domain PF01757. This family includes a range of acyltransferase enzymes. 9 transmembrane helices predicted by TMHMM2.0; acyltransferase domain-containing membrane protein complement(3815191..3817278) Arthrobacter arilaitensis Re117 9794353 YP_003918562.1 CDS AARI_34040 NC_014550.1 3817396 3817887 R match to PF01381: helix-turn-helix. This is large family of DNA binding helix-turn helix proteins that include a bacterial plasmid copy control protein, bacterial methylases, various bacteriophage transcription control proteins and a vegetative specific protein from Dictyostelium discoideum (Slime mould); hypothetical protein complement(3817396..3817887) Arthrobacter arilaitensis Re117 9797113 YP_003918563.1 CDS AARI_34050 NC_014550.1 3818027 3818578 R hypothetical protein complement(3818027..3818578) Arthrobacter arilaitensis Re117 9797114 YP_003918564.1 CDS AARI_34060 NC_014550.1 3818673 3819953 R match to protein family PF02127. This group of metallopeptidases belong to the MEROPS peptidase family M18, (clan MH). The catalysed reaction involves the release of an N-terminal aminoacid, usually neutral or hydrophobic, from a polypeptide; M18 family aminopeptidase complement(3818673..3819953) Arthrobacter arilaitensis Re117 9797115 YP_003918565.1 CDS AARI_34070 NC_014550.1 3820194 3820580 D 2 transmembrane helices predicted by TMHMM2.0; hypothetical protein 3820194..3820580 Arthrobacter arilaitensis Re117 9797116 YP_003918566.1 CDS AARI_34080 NC_014550.1 3820648 3821352 R response regulators are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions; two-component system response regulator complement(3820648..3821352) Arthrobacter arilaitensis Re117 9797117 YP_003918567.1 CDS AARI_34090 NC_014550.1 3821349 3822644 R protein-histidine kinases are key elements in two- component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. 5 transmembrane helices predicted by TMHMM2.0; signal transduction histidine kinase complement(3821349..3822644) Arthrobacter arilaitensis Re117 9797118 YP_003918568.1 CDS AARI_34100 NC_014550.1 3822679 3823524 R TC 3.A.1.y.z. ABCISSE: ABC transporter, permease (IM), DRI-family, DRB-subfamily (drug resistance, ). Possible function in drug efflux; drug ABC transporter inner membrane subunit complement(3822679..3823524) Arthrobacter arilaitensis Re117 9797119 YP_003918569.1 CDS AARI_34110 NC_014550.1 3823529 3824455 R TC 3.A.1.y.z. ABCISSE: ABC transporter, ATP-binding protein (ABC), DRI-family, DRB-subfamily (drug resistance, ). Possible function in drug efflux; drug resistance ATP-binding protein complement(3823529..3824455) Arthrobacter arilaitensis Re117 9797120 YP_003918570.1 CDS AARI_34120 NC_014550.1 3824594 3825622 R 6 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3824594..3825622) Arthrobacter arilaitensis Re117 9797121 YP_003918571.1 CDS AARI_34130 NC_014550.1 3825629 3827062 R hypothetical protein complement(3825629..3827062) Arthrobacter arilaitensis Re117 9797122 YP_003918572.1 CDS AARI_34140 NC_014550.1 3827059 3828522 R 8 transmembrane helices predicted by TMHMM2.0; hypothetical protein complement(3827059..3828522) Arthrobacter arilaitensis Re117 9797123 YP_003918573.1 CDS AARI_34150 NC_014550.1 3828762 3829946 D match to protein family PF02348. EC 2.7.7.43 catalyzes the reaction of CTP and NeuAc to form CMP-NeuAc, which is the nucleotide sugar donor used by sialyltransferases. The outer membrane lipooligosaccharides of some microorganisms contain terminal sialic acid attached to N-acetyllactosamine; N-acylneuraminate cytidylyltransferase 3828762..3829946 Arthrobacter arilaitensis Re117 9797124 YP_003918574.1 CDS AARI_34160 NC_014550.1 3829959 3830852 D match to protein family PF03102. EC 2.5.1.57 catalyses the direct formation of Neu5Ac (the most common sialic acid) by condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine (ManNAc); N-acylneuraminate-9-phosphate synthase 3829959..3830852 Arthrobacter arilaitensis Re117 9797125 YP_003918575.1 CDS AARI_34170 NC_014550.1 3830929 3831936 D match to PF00535: glycosyl transferase family 2. This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP- N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids; glycosyl transferase family 2 3830929..3831936 Arthrobacter arilaitensis Re117 9797126 YP_003918576.1 CDS AARI_34180 NC_014550.1 3831933 3833276 D hypothetical protein 3831933..3833276 Arthrobacter arilaitensis Re117 9797127 YP_003918577.1 CDS AARI_34190 NC_014550.1 3833273 3834298 D hypothetical protein 3833273..3834298 Arthrobacter arilaitensis Re117 9797128 YP_003918578.1 CDS AARI_34200 NC_014550.1 3834295 3835539 D hypothetical protein 3834295..3835539 Arthrobacter arilaitensis Re117 9797129 YP_003918579.1 CDS AARI_34210 NC_014550.1 3835835 3836920 D inositol-3-phosphate synthase is also named myo- inositol-1-phosphate synthase. It catalyses the conversion of glucose-6- phosphate to inositol-1-phosphate, which is then dephosphorylated to inositol. Inositol phosphates play an important role in signal transduction; inositol-3-phosphate synthase 3835835..3836920 Arthrobacter arilaitensis Re117 9797130 YP_003918580.1 CDS AARI_34220 NC_014550.1 3837106 3837228 R hypothetical protein complement(3837106..3837228) Arthrobacter arilaitensis Re117 9797131 YP_003918581.1 CDS AARI_34230 NC_014550.1 3837813 3839264 R identified by match to protein family TIGR02692. Can add or repair the required CCA triplet at the 3 -end of tRNA molecules; tRNA adenylyltransferase complement(3837813..3839264) Arthrobacter arilaitensis Re117 9797132 YP_003918582.1 CDS AARI_34240 NC_014550.1 3839389 3839928 D identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools and to maintain cell viability, thereby serving as surveillance and house- cleaning enzymes; NUDIX hydrolase 3839389..3839928 Arthrobacter arilaitensis Re117 9797133 YP_003918583.1 CDS AARI_34250 NC_014550.1 3840044 3841675 D identified by match to protein family PF03023. Deletion of the mviN virulence gene in Salmonella enterica serovar. Typhimurium greatly reduces virulence in a mouse model of typhoid-like disease. Open reading frames encoding homologues of MviN have since been identified in a variety of bacteria including pathogens and non- pathogens and plant-symbionts. In the nitrogen-fixing symbiont Rhizobium tropici, mviN is required for motility. The MviM protein is predicted to be membrane-associated; MviN-like protein 3840044..3841675 Arthrobacter arilaitensis Re117 9797134 YP_003918584.1 CDS AARI_34260 NC_014550.1 3841799 3843418 D 1 transmembrane helice predicted by TMHMM2.0; hypothetical protein 3841799..3843418 Arthrobacter arilaitensis Re117 9797135 YP_003918585.1 CDS trxB NC_014550.1 3843519 3844484 D catalyses the following reaction: thioredoxin + NADP(+) <=> thioredoxin disulfide + NADPH. It supplies reducing equivalents for a wide variety of reactions, for example for pyrimidine synthesis; thioredoxin-disulfide reductase 3843519..3844484 Arthrobacter arilaitensis Re117 9797136 YP_003918586.1 CDS trx NC_014550.1 3844513 3844836 D serves as a general protein disulphide oxidoreductase. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of 2 cysteine thiol groups to a disulphide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulphide and a dithiol; thioredoxin 3844513..3844836 Arthrobacter arilaitensis Re117 9794481 YP_003918587.1 CDS istA NC_014550.1 3846213 3847775 D transposase of ISAar33, IS21 family, istA 3846213..3847775 Arthrobacter arilaitensis Re117 9794480 YP_003918588.1 CDS istB NC_014550.1 3847772 3848518 D helper of transposition of ISAar33, IS21 family, istB 3847772..3848518 Arthrobacter arilaitensis Re117 9794018 YP_003918589.1 CDS parB NC_014550.1 3853028 3853975 R identified by match to TIGR00180. This HMM represents the most well-conserved core of a set of chromosomal and plasmid partition proteins related to ParB, including Spo0J, RepB, and SopB. Spo0J has been shown to bind a specific DNA sequence that, when introduced into a plasmid, can serve as partition site. Study of RepB, which has nicking-closing activity, suggests that it forms a transient protein-DNA covalent intermediate during the strand transfer reaction; chromosome-partitioning protein ParB complement(3853028..3853975) Arthrobacter arilaitensis Re117 9794022 YP_003918590.1 CDS parA NC_014550.1 3854867 3855790 R ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the initiation of DNA replication. ParB regulates the ParA ATPase activity by promoting nucleotide exchange in a fashion reminiscent of the exchange factors of eukaryotic G proteins. ADP-bound ParA binds single- stranded DNA, whereas the ATP-bound form dissociates ParB from its DNA binding sites. Increasing the fraction of ParA-ADP in the cell inhibits cell division, suggesting that this simple nucleotide switch may regulate cytokinesis; chromosome-partitioning protein ParA complement(3854867..3855790) Arthrobacter arilaitensis Re117 9794177 YP_003918591.1 CDS gidB NC_014550.1 3855968 3856609 R GidB (glucose-inhibited division protein B) appears to be present and in a single copy in all complete eubacterial genomes so far. Its mode of action is unknown, but a methytransferase fold is reported from the crystal structure. It may be a family of bacterial glucose inhibited division proteins that are involved in the regulation of cell division; glucose-inhibited division protein B complement(3855968..3856609) Arthrobacter arilaitensis Re117 9794176 YP_003918592.1 CDS AARI_34320 NC_014550.1 3856655 3857182 R identified by match to protein domain PF01424. The function of the domain is predicted to be binding ssDNA; R3H domain-containing protein complement(3856655..3857182) Arthrobacter arilaitensis Re117 9793898 YP_003918593.1 CDS yidC NC_014550.1 3857185 3858159 R The preprotein translocase itself comprises 7 proteins, including a chaperone protein (SecB), an ATPase (SecA), an integral membrane complex (SecCY, SecE and SecG), and two additional membrane proteins that promote the release of the mature peptide into the periplasm (SecD and SecF). Other cytoplasmic/periplasmic proteins play a part in preprotein translocase activity, namely YidC and YajC. The latter is bound in a complex to SecD and SecF, and plays a part in stabilising and regulating secretion through the SecYEG integral membrane component via SecA; preprotein translocase subunit YidC complement(3857185..3858159) Arthrobacter arilaitensis Re117 9797137 YP_003918594.1 CDS AARI_34340 NC_014550.1 3858159 3858536 R hypothetical protein complement(3858159..3858536) Arthrobacter arilaitensis Re117 9794517 YP_003918595.1 CDS rnpA NC_014550.1 3858536 3858889 R identified by match to protein family PF00825. Ribonuclease P (EC 3.1.26.5) is a site specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5 ends. In bacteria RNase P is known to be composed of two components: a large (about 400 base pairs) RNA (gene rnpB) and a small protein (119 to 133 amino acids) (gene rnpA); ribonuclease P protein component complement(3858536..3858889) Arthrobacter arilaitensis Re117 9797138 YP_003918596.1 CDS rpmH NC_014550.1 3858954 3859091 R one of the proteins from the large subunit of the prokaryotic ribosome; 50S ribosomal protein L34 complement(3858954..3859091) Arthrobacter arilaitensis Re117 9794306 AARI_36270 tRNA AARI_36270 NC_014550.1 10930 11003 D tRNA-Ile 10930..11003 Arthrobacter arilaitensis Re117 9795867 AARI_36280 tRNA AARI_36280 NC_014550.1 11161 11236 D tRNA-Ala 11161..11236 Arthrobacter arilaitensis Re117 9793563 AARI_36290 tRNA AARI_36290 NC_014550.1 11329 11401 D tRNA-Ala 11329..11401 Arthrobacter arilaitensis Re117 9793564 AARI_36300 tRNA AARI_36300 NC_014550.1 38148 38234 D tRNA-Leu 38148..38234 Arthrobacter arilaitensis Re117 9795893 AARI_36370 tRNA AARI_36370 NC_014550.1 134543 134618 D tRNA-Lys 134543..134618 Arthrobacter arilaitensis Re117 9796037 AARI_36410 tRNA AARI_36410 NC_014550.1 192736 192811 D tRNA-Glu 192736..192811 Arthrobacter arilaitensis Re117 9796087 AARI_36420 tRNA AARI_36420 NC_014550.1 192863 192936 D tRNA-Asp 192863..192936 Arthrobacter arilaitensis Re117 9793577 AARI_36430 tRNA AARI_36430 NC_014550.1 192986 193058 D tRNA-Phe 192986..193058 Arthrobacter arilaitensis Re117 9793578 AARI_36440 tRNA AARI_36440 NC_014550.1 193120 193193 D tRNA-Asp 193120..193193 Arthrobacter arilaitensis Re117 9793579 AARI_36450 tRNA AARI_36450 NC_014550.1 347449 347536 D tRNA-Ser 347449..347536 Arthrobacter arilaitensis Re117 9796262 AARI_36460 tRNA AARI_36460 NC_014550.1 518344 518434 R tRNA-Ser complement(518344..518434) Arthrobacter arilaitensis Re117 9796556 AARI_36470 tRNA AARI_36470 NC_014550.1 539342 539418 R tRNA-Arg complement(539342..539418) Arthrobacter arilaitensis Re117 9793734 AARI_36480 tRNA AARI_36480 NC_014550.1 540156 540232 R tRNA-Arg complement(540156..540232) Arthrobacter arilaitensis Re117 9796570 AARI_36490 tRNA AARI_36490 NC_014550.1 551613 551704 R tRNA-Ser complement(551613..551704) Arthrobacter arilaitensis Re117 9796577 AARI_36500 tRNA AARI_36500 NC_014550.1 555975 556062 R tRNA-Ser complement(555975..556062) Arthrobacter arilaitensis Re117 9796579 AARI_36510 tRNA AARI_36510 NC_014550.1 561363 561437 R tRNA-Thr complement(561363..561437) Arthrobacter arilaitensis Re117 9793816 AARI_36550 tRNA AARI_36550 NC_014550.1 586015 586091 D tRNA-Pro 586015..586091 Arthrobacter arilaitensis Re117 9796592 AARI_36560 tRNA AARI_36560 NC_014550.1 588321 588392 D tRNA-Gln 588321..588392 Arthrobacter arilaitensis Re117 9796594 AARI_36570 tRNA AARI_36570 NC_014550.1 588441 588516 D tRNA-Glu 588441..588516 Arthrobacter arilaitensis Re117 9793592 AARI_36610 tRNA AARI_36610 NC_014550.1 603741 603814 D tRNA-Thr 603741..603814 Arthrobacter arilaitensis Re117 9796678 AARI_36620 tRNA AARI_36620 NC_014550.1 608653 608729 D tRNA-Val 608653..608729 Arthrobacter arilaitensis Re117 9796682 AARI_36630 tRNA AARI_36630 NC_014550.1 628074 628150 R tRNA-Arg complement(628074..628150) Arthrobacter arilaitensis Re117 9796698 AARI_36640 tRNA AARI_36640 NC_014550.1 830672 830753 D tRNA-Leu 830672..830753 Arthrobacter arilaitensis Re117 9794136 AARI_36650 tRNA AARI_36650 NC_014550.1 889351 889425 D tRNA-Gln 889351..889425 Arthrobacter arilaitensis Re117 9797036 AARI_36660 tRNA AARI_36660 NC_014550.1 1051908 1051980 D tRNA-Asn 1051908..1051980 Arthrobacter arilaitensis Re117 9793824 AARI_36670 tRNA AARI_36670 NC_014550.1 1078227 1078302 D tRNA-Asn 1078227..1078302 Arthrobacter arilaitensis Re117 9795252 AARI_36680 tRNA AARI_36680 NC_014550.1 1081759 1081835 D tRNA-Met 1081759..1081835 Arthrobacter arilaitensis Re117 9795255 AARI_36720 tRNA AARI_36720 NC_014550.1 1323575 1323651 D tRNA-Pro 1323575..1323651 Arthrobacter arilaitensis Re117 9793834 AARI_36730 tRNA AARI_36730 NC_014550.1 1398627 1398702 R tRNA-Arg complement(1398627..1398702) Arthrobacter arilaitensis Re117 9795474 AARI_36740 tRNA AARI_36740 NC_014550.1 1531710 1531785 D tRNA-Lys 1531710..1531785 Arthrobacter arilaitensis Re117 9795551 AARI_36750 tRNA AARI_36750 NC_014550.1 1531832 1531907 D tRNA-Lys 1531832..1531907 Arthrobacter arilaitensis Re117 9793610 AARI_36760 tRNA AARI_36760 NC_014550.1 1532292 1532364 D tRNA-Lys 1532292..1532364 Arthrobacter arilaitensis Re117 9793611 AARI_36770 tRNA AARI_36770 NC_014550.1 1533015 1533099 D tRNA-Leu 1533015..1533099 Arthrobacter arilaitensis Re117 9793707 AARI_36780 tRNA AARI_36780 NC_014550.1 1629773 1629844 D tRNA-Gln 1629773..1629844 Arthrobacter arilaitensis Re117 9793920 AARI_36790 tRNA AARI_36790 NC_014550.1 1629893 1629968 D tRNA-Glu 1629893..1629968 Arthrobacter arilaitensis Re117 9793614 AARI_36800 tRNA AARI_36800 NC_014550.1 1766146 1766221 D tRNA-Val 1766146..1766221 Arthrobacter arilaitensis Re117 9795670 AARI_36810 tRNA AARI_36810 NC_014550.1 1766914 1766989 D tRNA-Val 1766914..1766989 Arthrobacter arilaitensis Re117 9795671 AARI_36820 tRNA AARI_36820 NC_014550.1 1809551 1809626 R tRNA-His complement(1809551..1809626) Arthrobacter arilaitensis Re117 9795707 AARI_36830 tRNA AARI_36830 NC_014550.1 1811776 1811851 R tRNA-His complement(1811776..1811851) Arthrobacter arilaitensis Re117 9793465 AARI_36840 tRNA AARI_36840 NC_014550.1 1849918 1850002 R tRNA-Leu complement(1849918..1850002) Arthrobacter arilaitensis Re117 9795739 AARI_36850 tRNA AARI_36850 NC_014550.1 2053657 2053732 R tRNA-Ala complement(2053657..2053732) Arthrobacter arilaitensis Re117 9794563 AARI_36860 tRNA AARI_36860 NC_014550.1 2105335 2105409 R tRNA-Pro complement(2105335..2105409) Arthrobacter arilaitensis Re117 9794453 AARI_36870 tRNA AARI_36870 NC_014550.1 2105566 2105640 R tRNA-Pro complement(2105566..2105640) Arthrobacter arilaitensis Re117 9793622 AARI_36880 tRNA AARI_36880 NC_014550.1 2105783 2105857 R tRNA-Pro complement(2105783..2105857) Arthrobacter arilaitensis Re117 9793623 AARI_36890 tRNA AARI_36890 NC_014550.1 2106620 2106693 R tRNA-Gly complement(2106620..2106693) Arthrobacter arilaitensis Re117 9793624 AARI_36900 tRNA AARI_36900 NC_014550.1 2123825 2123901 D tRNA-Arg 2123825..2123901 Arthrobacter arilaitensis Re117 9793476 AARI_36910 tRNA AARI_36910 NC_014550.1 2207970 2208054 D tRNA-Leu 2207970..2208054 Arthrobacter arilaitensis Re117 9794643 AARI_36920 tRNA AARI_36920 NC_014550.1 2241254 2241326 D tRNA-Gly 2241254..2241326 Arthrobacter arilaitensis Re117 9794652 AARI_36930 tRNA AARI_36930 NC_014550.1 2241381 2241451 D tRNA-Cys 2241381..2241451 Arthrobacter arilaitensis Re117 9793628 AARI_36940 tRNA AARI_36940 NC_014550.1 2241479 2241550 D tRNA-Val 2241479..2241550 Arthrobacter arilaitensis Re117 9793629 AARI_36950 tRNA AARI_36950 NC_014550.1 2241593 2241665 D tRNA-Gly 2241593..2241665 Arthrobacter arilaitensis Re117 9793630 AARI_36960 tRNA AARI_36960 NC_014550.1 2241719 2241790 D tRNA-Val 2241719..2241790 Arthrobacter arilaitensis Re117 9793631 AARI_36970 tRNA AARI_36970 NC_014550.1 2241833 2241908 D tRNA-Gly 2241833..2241908 Arthrobacter arilaitensis Re117 9793632 AARI_36980 tRNA AARI_36980 NC_014550.1 2241928 2242003 D tRNA-Gly 2241928..2242003 Arthrobacter arilaitensis Re117 9793633 AARI_36990 tRNA AARI_36990 NC_014550.1 2418721 2418797 R tRNA-Met complement(2418721..2418797) Arthrobacter arilaitensis Re117 9794763 AARI_37000 tRNA AARI_37000 NC_014550.1 2419111 2419187 R tRNA-Met complement(2419111..2419187) Arthrobacter arilaitensis Re117 9793635 AARI_37010 tRNA AARI_37010 NC_014550.1 2419599 2419675 R tRNA-Met complement(2419599..2419675) Arthrobacter arilaitensis Re117 9793636 AARI_37020 tRNA AARI_37020 NC_014550.1 2672788 2672860 R tRNA-Trp complement(2672788..2672860) Arthrobacter arilaitensis Re117 9794388 AARI_37030 tRNA AARI_37030 NC_014550.1 2697843 2697919 R tRNA-Met complement(2697843..2697919) Arthrobacter arilaitensis Re117 9794932 AARI_37040 tRNA AARI_37040 NC_014550.1 2697967 2698038 R tRNA-Thr complement(2697967..2698038) Arthrobacter arilaitensis Re117 9793639 AARI_37050 tRNA AARI_37050 NC_014550.1 2698552 2698626 D tRNA-Thr 2698552..2698626 Arthrobacter arilaitensis Re117 9793640 AARI_37060 tRNA AARI_37060 NC_014550.1 2707693 2707777 R tRNA-Tyr complement(2707693..2707777) Arthrobacter arilaitensis Re117 9794479 AARI_37070 tRNA AARI_37070 NC_014550.1 2875567 2875640 D tRNA-Gly 2875567..2875640 Arthrobacter arilaitensis Re117 9795043 AARI_37080 tRNA AARI_37080 NC_014550.1 3070610 3070685 R tRNA-Ala complement(3070610..3070685) Arthrobacter arilaitensis Re117 9795965 AARI_36310 rRNA AARI_36310 NC_014550.1 90954 92472 D 16S ribosomal RNA 90954..92472 Arthrobacter arilaitensis Re117 9795930 AARI_36320 rRNA AARI_36320 NC_014550.1 93107 96229 D 23S ribosomal RNA 93107..96229 Arthrobacter arilaitensis Re117 9793567 AARI_36330 rRNA AARI_36330 NC_014550.1 96386 96501 D 5S ribosomal RNA 96386..96501 Arthrobacter arilaitensis Re117 9793568 AARI_36340 rRNA AARI_36340 NC_014550.1 100378 101896 D 16S ribosomal RNA 100378..101896 Arthrobacter arilaitensis Re117 9795934 AARI_36350 rRNA AARI_36350 NC_014550.1 102531 105653 D 23S ribosomal RNA 102531..105653 Arthrobacter arilaitensis Re117 9793570 AARI_36360 rRNA AARI_36360 NC_014550.1 105810 105925 D 5S ribosomal RNA 105810..105925 Arthrobacter arilaitensis Re117 9793571 AARI_36380 rRNA AARI_36380 NC_014550.1 169443 170961 D 16S ribosomal RNA 169443..170961 Arthrobacter arilaitensis Re117 9796071 AARI_36390 rRNA AARI_36390 NC_014550.1 171595 174717 D 23S ribosomal RNA 171595..174717 Arthrobacter arilaitensis Re117 9793574 AARI_36400 rRNA AARI_36400 NC_014550.1 174874 174989 D 5S ribosomal RNA 174874..174989 Arthrobacter arilaitensis Re117 9793575 AARI_36520 rRNA AARI_36520 NC_014550.1 578113 579631 D 16S ribosomal RNA 578113..579631 Arthrobacter arilaitensis Re117 9796590 AARI_36530 rRNA AARI_36530 NC_014550.1 580265 583387 D 23S ribosomal RNA 580265..583387 Arthrobacter arilaitensis Re117 9793588 AARI_36540 rRNA AARI_36540 NC_014550.1 583544 583659 D 5S ribosomal RNA 583544..583659 Arthrobacter arilaitensis Re117 9793589 AARI_36580 rRNA AARI_36580 NC_014550.1 591247 592765 D 16S ribosomal RNA 591247..592765 Arthrobacter arilaitensis Re117 9797157 AARI_36590 rRNA AARI_36590 NC_014550.1 593399 596521 D 23S ribosomal RNA 593399..596521 Arthrobacter arilaitensis Re117 9793594 AARI_36600 rRNA AARI_36600 NC_014550.1 596678 596793 D 5S ribosomal RNA 596678..596793 Arthrobacter arilaitensis Re117 9793595 AARI_36690 rRNA AARI_36690 NC_014550.1 1283878 1285396 D 16S ribosomal RNA 1283878..1285396 Arthrobacter arilaitensis Re117 9794486 AARI_36700 rRNA AARI_36700 NC_014550.1 1286031 1289153 D 23S ribosomal RNA 1286031..1289153 Arthrobacter arilaitensis Re117 9793605 AARI_36710 rRNA AARI_36710 NC_014550.1 1289310 1289425 D 5S ribosomal RNA 1289310..1289425 Arthrobacter arilaitensis Re117 9793606