-- dump date 20140618_205409 -- class Genbank::misc_feature -- table misc_feature_note -- id note 290399000001 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 290399000002 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 290399000003 Phosphoesterase family; Region: Phosphoesterase; pfam04185 290399000004 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290399000005 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290399000006 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399000007 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290399000008 catalytic residues [active] 290399000009 catalytic nucleophile [active] 290399000010 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399000011 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399000012 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399000013 Synaptic Site I dimer interface [polypeptide binding]; other site 290399000014 DNA binding site [nucleotide binding] 290399000015 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399000016 DNA-binding interface [nucleotide binding]; DNA binding site 290399000017 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 290399000018 Homeodomain-like domain; Region: HTH_23; pfam13384 290399000019 Winged helix-turn helix; Region: HTH_29; pfam13551 290399000020 Integrase core domain; Region: rve; pfam00665 290399000021 Integrase core domain; Region: rve_3; cl15866 290399000022 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 290399000023 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399000024 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290399000025 catalytic residues [active] 290399000026 catalytic nucleophile [active] 290399000027 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399000028 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399000029 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399000030 Synaptic Site I dimer interface [polypeptide binding]; other site 290399000031 DNA binding site [nucleotide binding] 290399000032 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399000033 DNA-binding interface [nucleotide binding]; DNA binding site 290399000034 Putative zinc-finger; Region: zf-HC2; pfam13490 290399000035 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 290399000036 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399000037 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399000038 DNA binding residues [nucleotide binding] 290399000039 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290399000040 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290399000041 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 290399000042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399000043 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 290399000044 putative dimerization interface [polypeptide binding]; other site 290399000045 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 290399000046 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 290399000047 gating phenylalanine in ion channel; other site 290399000048 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 290399000049 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290399000050 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290399000051 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290399000052 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 290399000053 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 290399000054 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290399000055 catalytic residues [active] 290399000056 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290399000057 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290399000058 dimer interface [polypeptide binding]; other site 290399000059 ssDNA binding site [nucleotide binding]; other site 290399000060 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290399000061 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399000062 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 290399000063 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 290399000064 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 290399000065 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290399000066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290399000067 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290399000068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399000069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290399000070 non-specific DNA binding site [nucleotide binding]; other site 290399000071 salt bridge; other site 290399000072 sequence-specific DNA binding site [nucleotide binding]; other site 290399000073 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 290399000074 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290399000075 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399000076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399000077 DNA-binding site [nucleotide binding]; DNA binding site 290399000078 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290399000079 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290399000080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000081 putative DNA binding site [nucleotide binding]; other site 290399000082 putative Zn2+ binding site [ion binding]; other site 290399000083 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290399000084 FeoA domain; Region: FeoA; pfam04023 290399000085 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290399000086 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290399000087 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 290399000088 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290399000089 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290399000090 Multicopper oxidase; Region: Cu-oxidase; pfam00394 290399000091 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290399000092 Predicted membrane protein [Function unknown]; Region: COG3462 290399000093 hypothetical protein; Provisional; Region: PRK02237 290399000094 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 290399000095 diiron binding motif [ion binding]; other site 290399000096 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 290399000097 CHAP domain; Region: CHAP; cl17642 290399000098 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 290399000099 putative active site [active] 290399000100 redox center [active] 290399000101 lipoprotein signal peptidase; Provisional; Region: PRK14781 290399000102 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290399000103 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399000104 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399000105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000106 dimerization interface [polypeptide binding]; other site 290399000107 putative DNA binding site [nucleotide binding]; other site 290399000108 putative Zn2+ binding site [ion binding]; other site 290399000109 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290399000110 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290399000111 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290399000112 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290399000113 catalytic residues [active] 290399000114 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399000115 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290399000116 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 290399000117 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290399000118 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 290399000119 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290399000120 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 290399000121 CopC domain; Region: CopC; pfam04234 290399000122 Thioredoxin; Region: Thioredoxin_4; pfam13462 290399000123 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290399000124 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 290399000125 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000126 dimerization interface [polypeptide binding]; other site 290399000127 putative DNA binding site [nucleotide binding]; other site 290399000128 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399000129 putative Zn2+ binding site [ion binding]; other site 290399000130 Copper resistance protein D; Region: CopD; pfam05425 290399000131 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290399000132 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000133 putative DNA binding site [nucleotide binding]; other site 290399000134 putative Zn2+ binding site [ion binding]; other site 290399000135 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290399000136 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290399000137 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399000138 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399000139 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 290399000140 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 290399000141 dimerization interface [polypeptide binding]; other site 290399000142 putative DNA binding site [nucleotide binding]; other site 290399000143 putative Zn2+ binding site [ion binding]; other site 290399000144 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290399000145 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290399000146 Peptidase family M23; Region: Peptidase_M23; pfam01551 290399000147 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290399000148 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 290399000149 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290399000150 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 290399000151 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 290399000152 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290399000153 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399000154 catalytic residues [active] 290399000155 catalytic nucleophile [active] 290399000156 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399000157 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399000158 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399000159 Synaptic Site I dimer interface [polypeptide binding]; other site 290399000160 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399000161 DNA-binding interface [nucleotide binding]; DNA binding site 290399000162 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290399000163 BNR repeat-like domain; Region: BNR_2; pfam13088 290399000164 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290399000165 dimerization interface [polypeptide binding]; other site 290399000166 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290399000167 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 290399000168 DNA binding residues [nucleotide binding] 290399000169 dimer interface [polypeptide binding]; other site 290399000170 metal binding site [ion binding]; metal-binding site 290399000171 mercuric reductase; Region: MerA; TIGR02053 290399000172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399000173 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399000174 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290399000175 dimer interface [polypeptide binding]; other site 290399000176 Alkaline phosphatase homologues; Region: alkPPc; smart00098 290399000177 active site 290399000178 Sodium Bile acid symporter family; Region: SBF; cl17470 290399000179 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290399000180 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290399000181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399000182 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399000183 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290399000184 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 290399000185 ResB-like family; Region: ResB; pfam05140 290399000186 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290399000187 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290399000188 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290399000189 catalytic residues [active] 290399000190 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290399000191 Cytochrome P450; Region: p450; cl12078 290399000192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000193 dimerization interface [polypeptide binding]; other site 290399000194 putative DNA binding site [nucleotide binding]; other site 290399000195 putative Zn2+ binding site [ion binding]; other site 290399000196 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290399000197 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399000198 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399000199 lipoprotein signal peptidase; Provisional; Region: PRK14781 290399000200 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290399000201 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290399000202 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 290399000203 Cadmium resistance transporter; Region: Cad; pfam03596 290399000204 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 290399000205 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 290399000206 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 290399000207 ATP binding site [chemical binding]; other site 290399000208 substrate interface [chemical binding]; other site 290399000209 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 290399000210 Short C-terminal domain; Region: SHOCT; pfam09851 290399000211 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 290399000212 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290399000213 Ycf48-like protein; Provisional; Region: PRK13684 290399000214 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290399000215 Multicopper oxidase; Region: Cu-oxidase; pfam00394 290399000216 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290399000217 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290399000218 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 290399000219 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 290399000220 NADH dehydrogenase; Region: NADHdh; cl00469 290399000221 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 290399000222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290399000223 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 290399000224 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290399000225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290399000226 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 290399000227 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 290399000228 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 290399000229 ATP binding site [chemical binding]; other site 290399000230 Walker A motif; other site 290399000231 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 290399000232 Walker B motif; other site 290399000233 AAA-like domain; Region: AAA_10; pfam12846 290399000234 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290399000235 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399000236 CHAP domain; Region: CHAP; cl17642 290399000237 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 290399000238 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290399000239 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399000240 Magnesium ion binding site [ion binding]; other site 290399000241 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 290399000242 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 290399000243 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399000244 active site 290399000245 catalytic residues [active] 290399000246 DNA binding site [nucleotide binding] 290399000247 Int/Topo IB signature motif; other site 290399000248 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399000249 active site 290399000250 catalytic residues [active] 290399000251 DNA binding site [nucleotide binding] 290399000252 Int/Topo IB signature motif; other site 290399000253 Transposase, Mutator family; Region: Transposase_mut; pfam00872 290399000254 MULE transposase domain; Region: MULE; pfam10551 290399000255 D-mannose binding lectin; Region: B_lectin; pfam01453 290399000256 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 290399000257 mannose binding site [chemical binding]; other site 290399000258 dimerization interface [polypeptide binding]; other site 290399000259 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 290399000260 mannose binding site [chemical binding]; other site 290399000261 dimerization interface [polypeptide binding]; other site 290399000262 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 290399000263 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 290399000264 dimerization interface [polypeptide binding]; other site 290399000265 mannose binding site [chemical binding]; other site 290399000266 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290399000267 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290399000268 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 290399000269 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 290399000270 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 290399000271 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290399000272 Walker A/P-loop; other site 290399000273 ATP binding site [chemical binding]; other site 290399000274 Q-loop/lid; other site 290399000275 ABC transporter signature motif; other site 290399000276 Walker B; other site 290399000277 D-loop; other site 290399000278 H-loop/switch region; other site 290399000279 Putative esterase; Region: Esterase; pfam00756 290399000280 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 290399000281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399000282 dimer interface [polypeptide binding]; other site 290399000283 phosphorylation site [posttranslational modification] 290399000284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399000285 ATP binding site [chemical binding]; other site 290399000286 Mg2+ binding site [ion binding]; other site 290399000287 G-X-G motif; other site 290399000288 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399000289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399000290 active site 290399000291 phosphorylation site [posttranslational modification] 290399000292 intermolecular recognition site; other site 290399000293 dimerization interface [polypeptide binding]; other site 290399000294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399000295 DNA binding site [nucleotide binding] 290399000296 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 290399000297 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290399000298 active site 290399000299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399000300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399000301 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 290399000302 substrate binding pocket [chemical binding]; other site 290399000303 dimerization interface [polypeptide binding]; other site 290399000304 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 290399000305 SIR2-like domain; Region: SIR2_2; pfam13289 290399000306 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 290399000307 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 290399000308 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290399000309 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399000310 active site 290399000311 catalytic residues [active] 290399000312 DNA binding site [nucleotide binding] 290399000313 Int/Topo IB signature motif; other site 290399000314 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 290399000315 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290399000316 AAA-like domain; Region: AAA_10; pfam12846 290399000317 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399000318 CHAP domain; Region: CHAP; cl17642 290399000319 AAA domain; Region: AAA_31; pfam13614 290399000320 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 290399000321 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 290399000322 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 290399000323 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290399000324 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399000325 catalytic residues [active] 290399000326 catalytic nucleophile [active] 290399000327 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399000328 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399000329 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399000330 Synaptic Site I dimer interface [polypeptide binding]; other site 290399000331 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399000332 DNA-binding interface [nucleotide binding]; DNA binding site 290399000333 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290399000334 BNR repeat-like domain; Region: BNR_2; pfam13088 290399000335 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290399000336 dimerization interface [polypeptide binding]; other site 290399000337 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290399000338 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 290399000339 DNA binding residues [nucleotide binding] 290399000340 dimer interface [polypeptide binding]; other site 290399000341 metal binding site [ion binding]; metal-binding site 290399000342 mercuric reductase; Region: MerA; TIGR02053 290399000343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399000344 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399000345 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290399000346 dimer interface [polypeptide binding]; other site 290399000347 Alkaline phosphatase homologues; Region: alkPPc; smart00098 290399000348 active site 290399000349 Sodium Bile acid symporter family; Region: SBF; cl17470 290399000350 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290399000351 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290399000352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399000353 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399000354 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290399000355 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 290399000356 ResB-like family; Region: ResB; pfam05140 290399000357 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290399000358 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290399000359 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290399000360 catalytic residues [active] 290399000361 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290399000362 Cytochrome P450; Region: p450; cl12078 290399000363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000364 dimerization interface [polypeptide binding]; other site 290399000365 putative DNA binding site [nucleotide binding]; other site 290399000366 putative Zn2+ binding site [ion binding]; other site 290399000367 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290399000368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399000369 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399000370 lipoprotein signal peptidase; Provisional; Region: PRK14781 290399000371 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290399000372 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290399000373 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 290399000374 Cadmium resistance transporter; Region: Cad; pfam03596 290399000375 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 290399000376 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 290399000377 Winged helix-turn helix; Region: HTH_29; pfam13551 290399000378 Integrase core domain; Region: rve; pfam00665 290399000379 Integrase core domain; Region: rve_3; pfam13683 290399000380 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399000381 Magnesium ion binding site [ion binding]; other site 290399000382 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290399000383 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399000384 catalytic residues [active] 290399000385 catalytic nucleophile [active] 290399000386 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399000387 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399000388 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399000389 Synaptic Site I dimer interface [polypeptide binding]; other site 290399000390 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399000391 DNA-binding interface [nucleotide binding]; DNA binding site 290399000392 Predicted helicase [General function prediction only]; Region: COG4889 290399000393 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 290399000394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399000395 ATP binding site [chemical binding]; other site 290399000396 putative Mg++ binding site [ion binding]; other site 290399000397 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290399000398 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 290399000399 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290399000400 ParB-like nuclease domain; Region: ParBc; pfam02195 290399000401 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 290399000402 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 290399000403 Competence protein CoiA-like family; Region: CoiA; cl11541 290399000404 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290399000405 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 290399000406 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 290399000407 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290399000408 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399000409 active site 290399000410 catalytic residues [active] 290399000411 DNA binding site [nucleotide binding] 290399000412 Int/Topo IB signature motif; other site 290399000413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399000414 putative substrate translocation pore; other site 290399000415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399000416 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399000417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399000418 DNA-binding site [nucleotide binding]; DNA binding site 290399000419 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290399000420 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 290399000421 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 290399000422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290399000423 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399000424 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290399000425 iron-sulfur cluster [ion binding]; other site 290399000426 [2Fe-2S] cluster binding site [ion binding]; other site 290399000427 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 290399000428 beta subunit interface [polypeptide binding]; other site 290399000429 alpha subunit interface [polypeptide binding]; other site 290399000430 active site 290399000431 substrate binding site [chemical binding]; other site 290399000432 Fe binding site [ion binding]; other site 290399000433 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 290399000434 inter-subunit interface; other site 290399000435 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399000436 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 290399000437 intersubunit interface [polypeptide binding]; other site 290399000438 active site 290399000439 Zn2+ binding site [ion binding]; other site 290399000440 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399000441 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 290399000442 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 290399000443 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 290399000444 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 290399000445 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 290399000446 NMT1/THI5 like; Region: NMT1; pfam09084 290399000447 membrane-bound complex binding site; other site 290399000448 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290399000449 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290399000450 Walker A/P-loop; other site 290399000451 ATP binding site [chemical binding]; other site 290399000452 Q-loop/lid; other site 290399000453 ABC transporter signature motif; other site 290399000454 Walker B; other site 290399000455 D-loop; other site 290399000456 H-loop/switch region; other site 290399000457 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399000458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399000459 dimer interface [polypeptide binding]; other site 290399000460 conserved gate region; other site 290399000461 putative PBP binding loops; other site 290399000462 ABC-ATPase subunit interface; other site 290399000463 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399000464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399000465 dimer interface [polypeptide binding]; other site 290399000466 conserved gate region; other site 290399000467 ABC-ATPase subunit interface; other site 290399000468 Isochorismatase family; Region: Isochorismatase; pfam00857 290399000469 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 290399000470 catalytic triad [active] 290399000471 substrate binding site [chemical binding]; other site 290399000472 domain interfaces; other site 290399000473 conserved cis-peptide bond; other site 290399000474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399000475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399000476 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399000477 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399000478 active site 290399000479 catalytic tetrad [active] 290399000480 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290399000481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290399000482 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290399000483 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 290399000484 alpha subunit interaction site [polypeptide binding]; other site 290399000485 beta subunit interaction site [polypeptide binding]; other site 290399000486 iron-sulfur cluster [ion binding]; other site 290399000487 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 290399000488 beta subunit interface [polypeptide binding]; other site 290399000489 alpha subunit interface [polypeptide binding]; other site 290399000490 active site 290399000491 substrate binding site [chemical binding]; other site 290399000492 Fe binding site [ion binding]; other site 290399000493 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 290399000494 inter-subunit interface; other site 290399000495 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 290399000496 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290399000497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399000498 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 290399000499 intersubunit interface [polypeptide binding]; other site 290399000500 active site 290399000501 Zn2+ binding site [ion binding]; other site 290399000502 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399000503 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399000504 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399000505 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 290399000506 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290399000507 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399000508 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399000509 active site 290399000510 catalytic tetrad [active] 290399000511 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399000512 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399000513 protocatechuate 4,5-dioxygenase; Provisional; Region: pcmA; PRK13372 290399000514 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 290399000515 tetramer interface [polypeptide binding]; other site 290399000516 dimer interface [polypeptide binding]; other site 290399000517 active site 290399000518 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 290399000519 active site 290399000520 Fe(II) binding site [ion binding]; other site 290399000521 dimer interface [polypeptide binding]; other site 290399000522 tetramer interface [polypeptide binding]; other site 290399000523 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 290399000524 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 290399000525 active site 290399000526 hypothetical protein; Provisional; Region: PRK09262 290399000527 Amidohydrolase; Region: Amidohydro_2; pfam04909 290399000528 Methyltransferase domain; Region: Methyltransf_26; pfam13659 290399000529 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 290399000530 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290399000531 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 290399000532 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290399000533 nucleotide binding region [chemical binding]; other site 290399000534 ATP-binding site [chemical binding]; other site 290399000535 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 290399000536 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290399000537 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399000538 P-loop; other site 290399000539 Magnesium ion binding site [ion binding]; other site 290399000540 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399000541 Magnesium ion binding site [ion binding]; other site 290399000542 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 290399000543 Helix-turn-helix domain; Region: HTH_20; pfam12840 290399000544 putative DNA binding site [nucleotide binding]; other site 290399000545 putative Zn2+ binding site [ion binding]; other site 290399000546 CHAP domain; Region: CHAP; cl17642 290399000547 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290399000548 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399000549 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 290399000550 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 290399000551 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290399000552 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399000553 catalytic residues [active] 290399000554 catalytic nucleophile [active] 290399000555 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399000556 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399000557 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399000558 Synaptic Site I dimer interface [polypeptide binding]; other site 290399000559 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399000560 DNA-binding interface [nucleotide binding]; DNA binding site 290399000561 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290399000562 BNR repeat-like domain; Region: BNR_2; pfam13088 290399000563 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290399000564 dimerization interface [polypeptide binding]; other site 290399000565 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290399000566 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 290399000567 DNA binding residues [nucleotide binding] 290399000568 dimer interface [polypeptide binding]; other site 290399000569 metal binding site [ion binding]; metal-binding site 290399000570 mercuric reductase; Region: MerA; TIGR02053 290399000571 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399000572 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399000573 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290399000574 dimer interface [polypeptide binding]; other site 290399000575 Alkaline phosphatase homologues; Region: alkPPc; smart00098 290399000576 active site 290399000577 Sodium Bile acid symporter family; Region: SBF; cl17470 290399000578 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290399000579 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290399000580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399000581 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399000582 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290399000583 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 290399000584 ResB-like family; Region: ResB; pfam05140 290399000585 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290399000586 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290399000587 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290399000588 catalytic residues [active] 290399000589 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290399000590 Cytochrome P450; Region: p450; cl12078 290399000591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000592 dimerization interface [polypeptide binding]; other site 290399000593 putative DNA binding site [nucleotide binding]; other site 290399000594 putative Zn2+ binding site [ion binding]; other site 290399000595 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290399000596 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399000597 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399000598 lipoprotein signal peptidase; Provisional; Region: PRK14781 290399000599 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290399000600 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290399000601 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 290399000602 Cadmium resistance transporter; Region: Cad; pfam03596 290399000603 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 290399000604 AAA-like domain; Region: AAA_10; pfam12846 290399000605 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 290399000606 catalytic residue [active] 290399000607 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290399000608 active site 290399000609 Int/Topo IB signature motif; other site 290399000610 DNA binding site [nucleotide binding] 290399000611 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 290399000612 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290399000613 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399000614 active site 290399000615 catalytic residues [active] 290399000616 DNA binding site [nucleotide binding] 290399000617 Int/Topo IB signature motif; other site 290399000618 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 290399000619 ATP binding site [chemical binding]; other site 290399000620 Walker A motif; other site 290399000621 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 290399000622 Walker B motif; other site 290399000623 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399000624 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399000625 active site 290399000626 ATP binding site [chemical binding]; other site 290399000627 substrate binding site [chemical binding]; other site 290399000628 activation loop (A-loop); other site 290399000629 Transcriptional regulator; Region: Rrf2; cl17282 290399000630 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 290399000631 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 290399000632 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399000633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399000634 ABC transporter signature motif; other site 290399000635 Walker B; other site 290399000636 D-loop; other site 290399000637 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290399000638 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290399000639 dimer interface [polypeptide binding]; other site 290399000640 ssDNA binding site [nucleotide binding]; other site 290399000641 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290399000642 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290399000643 catalytic residues [active] 290399000644 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290399000645 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 290399000646 catalytic residues [active] 290399000647 Cation efflux family; Region: Cation_efflux; pfam01545 290399000648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000649 putative DNA binding site [nucleotide binding]; other site 290399000650 dimerization interface [polypeptide binding]; other site 290399000651 putative Zn2+ binding site [ion binding]; other site 290399000652 hypothetical protein; Provisional; Region: PRK02237 290399000653 Protein of unknown function, DUF488; Region: DUF488; pfam04343 290399000654 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 290399000655 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290399000656 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399000657 catalytic residues [active] 290399000658 catalytic nucleophile [active] 290399000659 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399000660 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399000661 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399000662 Synaptic Site I dimer interface [polypeptide binding]; other site 290399000663 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399000664 DNA-binding interface [nucleotide binding]; DNA binding site 290399000665 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 290399000666 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 290399000667 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 290399000668 Chromate transporter; Region: Chromate_transp; pfam02417 290399000669 Chromate transporter; Region: Chromate_transp; cl17781 290399000670 PQQ-like domain; Region: PQQ_2; pfam13360 290399000671 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 290399000672 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 290399000673 malate:quinone oxidoreductase; Validated; Region: PRK05257 290399000674 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 290399000675 Phosphotransferase enzyme family; Region: APH; pfam01636 290399000676 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290399000677 active site 290399000678 ATP binding site [chemical binding]; other site 290399000679 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399000680 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399000681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399000682 Walker A/P-loop; other site 290399000683 ATP binding site [chemical binding]; other site 290399000684 Q-loop/lid; other site 290399000685 ABC transporter signature motif; other site 290399000686 Walker B; other site 290399000687 D-loop; other site 290399000688 H-loop/switch region; other site 290399000689 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 290399000690 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399000691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399000692 Walker A/P-loop; other site 290399000693 ATP binding site [chemical binding]; other site 290399000694 Q-loop/lid; other site 290399000695 ABC transporter signature motif; other site 290399000696 Walker B; other site 290399000697 D-loop; other site 290399000698 H-loop/switch region; other site 290399000699 histidinol dehydrogenase; Region: hisD; TIGR00069 290399000700 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290399000701 NAD binding site [chemical binding]; other site 290399000702 dimerization interface [polypeptide binding]; other site 290399000703 product binding site; other site 290399000704 substrate binding site [chemical binding]; other site 290399000705 zinc binding site [ion binding]; other site 290399000706 catalytic residues [active] 290399000707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000708 dimerization interface [polypeptide binding]; other site 290399000709 putative DNA binding site [nucleotide binding]; other site 290399000710 putative Zn2+ binding site [ion binding]; other site 290399000711 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290399000712 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 290399000713 H+ Antiporter protein; Region: 2A0121; TIGR00900 290399000714 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399000715 dimerization interface [polypeptide binding]; other site 290399000716 putative DNA binding site [nucleotide binding]; other site 290399000717 putative Zn2+ binding site [ion binding]; other site 290399000718 CopC domain; Region: CopC; pfam04234 290399000719 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 290399000720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399000721 Walker A motif; other site 290399000722 ATP binding site [chemical binding]; other site 290399000723 Walker B motif; other site 290399000724 arginine finger; other site 290399000725 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290399000726 DnaA box-binding interface [nucleotide binding]; other site 290399000727 DNA polymerase III subunit beta; Validated; Region: PRK07761 290399000728 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 290399000729 putative DNA binding surface [nucleotide binding]; other site 290399000730 dimer interface [polypeptide binding]; other site 290399000731 beta-clamp/clamp loader binding surface; other site 290399000732 beta-clamp/translesion DNA polymerase binding surface; other site 290399000733 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399000734 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 290399000735 recombination protein F; Reviewed; Region: recF; PRK00064 290399000736 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 290399000737 Walker A/P-loop; other site 290399000738 ATP binding site [chemical binding]; other site 290399000739 Q-loop/lid; other site 290399000740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399000741 ABC transporter signature motif; other site 290399000742 Walker B; other site 290399000743 D-loop; other site 290399000744 H-loop/switch region; other site 290399000745 Protein of unknown function (DUF721); Region: DUF721; cl02324 290399000746 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 290399000747 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290399000748 anchoring element; other site 290399000749 dimer interface [polypeptide binding]; other site 290399000750 ATP binding site [chemical binding]; other site 290399000751 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 290399000752 active site 290399000753 putative metal-binding site [ion binding]; other site 290399000754 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290399000755 DNA gyrase subunit A; Validated; Region: PRK05560 290399000756 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290399000757 CAP-like domain; other site 290399000758 active site 290399000759 primary dimer interface [polypeptide binding]; other site 290399000760 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290399000761 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290399000762 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290399000763 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290399000764 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290399000765 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290399000766 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 290399000767 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290399000768 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290399000769 active site 290399000770 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399000771 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 290399000772 active site 290399000773 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 290399000774 Zn2+ binding site [ion binding]; other site 290399000775 Rhomboid family; Region: Rhomboid; pfam01694 290399000776 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 290399000777 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 290399000778 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 290399000779 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 290399000780 active site 290399000781 catalytic site [active] 290399000782 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290399000783 Glutamine amidotransferase class-I; Region: GATase; pfam00117 290399000784 glutamine binding [chemical binding]; other site 290399000785 catalytic triad [active] 290399000786 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290399000787 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399000788 active site 290399000789 ATP binding site [chemical binding]; other site 290399000790 substrate binding site [chemical binding]; other site 290399000791 activation loop (A-loop); other site 290399000792 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399000793 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399000794 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399000795 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399000796 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399000797 active site 290399000798 ATP binding site [chemical binding]; other site 290399000799 substrate binding site [chemical binding]; other site 290399000800 activation loop (A-loop); other site 290399000801 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399000802 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399000803 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 290399000804 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290399000805 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 290399000806 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 290399000807 active site 290399000808 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290399000809 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290399000810 phosphopeptide binding site; other site 290399000811 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 290399000812 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290399000813 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290399000814 phosphopeptide binding site; other site 290399000815 NMT1/THI5 like; Region: NMT1; pfam09084 290399000816 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290399000817 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290399000818 Walker A/P-loop; other site 290399000819 ATP binding site [chemical binding]; other site 290399000820 Q-loop/lid; other site 290399000821 ABC transporter signature motif; other site 290399000822 Walker B; other site 290399000823 D-loop; other site 290399000824 H-loop/switch region; other site 290399000825 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399000826 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399000827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399000828 putative PBP binding loops; other site 290399000829 ABC-ATPase subunit interface; other site 290399000830 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399000831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399000832 DNA-binding site [nucleotide binding]; DNA binding site 290399000833 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290399000834 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290399000835 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290399000836 active site pocket [active] 290399000837 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 290399000838 Predicted permeases [General function prediction only]; Region: COG0679 290399000839 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 290399000840 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 290399000841 substrate binding pocket [chemical binding]; other site 290399000842 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 290399000843 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 290399000844 dimer interface [polypeptide binding]; other site 290399000845 NADP binding site [chemical binding]; other site 290399000846 catalytic residues [active] 290399000847 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 290399000848 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290399000849 putative active site [active] 290399000850 catalytic residue [active] 290399000851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399000852 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 290399000853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290399000854 dimerization interface [polypeptide binding]; other site 290399000855 tetracycline repressor protein TetR; Provisional; Region: PRK13756 290399000856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399000857 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290399000858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399000859 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290399000860 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399000861 Ligand Binding Site [chemical binding]; other site 290399000862 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399000863 Ligand Binding Site [chemical binding]; other site 290399000864 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290399000865 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 290399000866 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290399000867 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399000868 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290399000869 PspC domain; Region: PspC; pfam04024 290399000870 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 290399000871 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399000872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399000873 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 290399000874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399000875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399000876 dimer interface [polypeptide binding]; other site 290399000877 conserved gate region; other site 290399000878 putative PBP binding loops; other site 290399000879 ABC-ATPase subunit interface; other site 290399000880 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 290399000881 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399000882 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399000883 DNA binding site [nucleotide binding] 290399000884 domain linker motif; other site 290399000885 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290399000886 putative dimerization interface [polypeptide binding]; other site 290399000887 putative ligand binding site [chemical binding]; other site 290399000888 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399000889 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290399000890 putative substrate binding site [chemical binding]; other site 290399000891 putative ATP binding site [chemical binding]; other site 290399000892 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290399000893 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290399000894 substrate binding [chemical binding]; other site 290399000895 active site 290399000896 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290399000897 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 290399000898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290399000899 dimerization interface [polypeptide binding]; other site 290399000900 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290399000901 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290399000902 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290399000903 lipoyl synthase; Provisional; Region: PRK05481 290399000904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399000905 FeS/SAM binding site; other site 290399000906 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 290399000907 FAD binding site [chemical binding]; other site 290399000908 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290399000909 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290399000910 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 290399000911 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 290399000912 putative NAD(P) binding site [chemical binding]; other site 290399000913 A new structural DNA glycosylase; Region: AlkD_like; cd06561 290399000914 active site 290399000915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399000916 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290399000917 NAD(P) binding site [chemical binding]; other site 290399000918 active site 290399000919 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399000920 catalytic core [active] 290399000921 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290399000922 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290399000923 active site 290399000924 catalytic triad [active] 290399000925 oxyanion hole [active] 290399000926 Domain of unknown function (DUF202); Region: DUF202; pfam02656 290399000927 Domain of unknown function (DUF202); Region: DUF202; cl09954 290399000928 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290399000929 Isochorismatase family; Region: Isochorismatase; pfam00857 290399000930 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 290399000931 catalytic triad [active] 290399000932 conserved cis-peptide bond; other site 290399000933 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 290399000934 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290399000935 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290399000936 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399000937 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399000938 DNA binding site [nucleotide binding] 290399000939 domain linker motif; other site 290399000940 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399000941 dimerization interface [polypeptide binding]; other site 290399000942 ligand binding site [chemical binding]; other site 290399000943 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 290399000944 active site 290399000945 tetramer interface [polypeptide binding]; other site 290399000946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399000947 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290399000948 putative substrate translocation pore; other site 290399000949 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399000950 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290399000951 substrate binding site [chemical binding]; other site 290399000952 dimer interface [polypeptide binding]; other site 290399000953 ATP binding site [chemical binding]; other site 290399000954 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399000955 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399000956 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399000957 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290399000958 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399000959 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290399000960 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399000961 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399000962 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399000963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399000964 dimer interface [polypeptide binding]; other site 290399000965 conserved gate region; other site 290399000966 putative PBP binding loops; other site 290399000967 ABC-ATPase subunit interface; other site 290399000968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399000969 dimer interface [polypeptide binding]; other site 290399000970 conserved gate region; other site 290399000971 putative PBP binding loops; other site 290399000972 ABC-ATPase subunit interface; other site 290399000973 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399000974 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399000975 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399000976 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399000977 DNA binding site [nucleotide binding] 290399000978 domain linker motif; other site 290399000979 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290399000980 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399000981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399000982 DNA-binding site [nucleotide binding]; DNA binding site 290399000983 FCD domain; Region: FCD; pfam07729 290399000984 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 290399000985 putative active site [active] 290399000986 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399000987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399000988 putative substrate translocation pore; other site 290399000989 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290399000990 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 290399000991 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 290399000992 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 290399000993 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290399000994 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290399000995 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290399000996 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290399000997 carboxyltransferase (CT) interaction site; other site 290399000998 biotinylation site [posttranslational modification]; other site 290399000999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399001000 dimerization interface [polypeptide binding]; other site 290399001001 putative DNA binding site [nucleotide binding]; other site 290399001002 putative Zn2+ binding site [ion binding]; other site 290399001003 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290399001004 PAS fold; Region: PAS_3; pfam08447 290399001005 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399001006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399001007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399001008 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 290399001009 Sodium Bile acid symporter family; Region: SBF; pfam01758 290399001010 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290399001011 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290399001012 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290399001013 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290399001014 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290399001015 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290399001016 synthetase active site [active] 290399001017 NTP binding site [chemical binding]; other site 290399001018 metal binding site [ion binding]; metal-binding site 290399001019 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290399001020 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290399001021 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 290399001022 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290399001023 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290399001024 active site residue [active] 290399001025 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399001026 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290399001027 putative substrate binding site [chemical binding]; other site 290399001028 putative ATP binding site [chemical binding]; other site 290399001029 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 290399001030 substrate binding site [chemical binding]; other site 290399001031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399001032 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 290399001033 active site 290399001034 motif I; other site 290399001035 motif II; other site 290399001036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399001037 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 290399001038 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 290399001039 putative active site [active] 290399001040 catalytic site [active] 290399001041 putative metal binding site [ion binding]; other site 290399001042 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290399001043 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290399001044 metal binding site [ion binding]; metal-binding site 290399001045 active site 290399001046 I-site; other site 290399001047 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399001048 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290399001049 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290399001050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290399001051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399001052 dimer interface [polypeptide binding]; other site 290399001053 phosphorylation site [posttranslational modification] 290399001054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399001055 ATP binding site [chemical binding]; other site 290399001056 Mg2+ binding site [ion binding]; other site 290399001057 G-X-G motif; other site 290399001058 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290399001059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399001060 S-adenosylmethionine binding site [chemical binding]; other site 290399001061 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290399001062 putative substrate binding site [chemical binding]; other site 290399001063 putative ATP binding site [chemical binding]; other site 290399001064 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399001065 catalytic core [active] 290399001066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399001067 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290399001068 catalytic site [active] 290399001069 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 290399001070 short chain dehydrogenase; Provisional; Region: PRK06701 290399001071 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290399001072 NAD binding site [chemical binding]; other site 290399001073 metal binding site [ion binding]; metal-binding site 290399001074 active site 290399001075 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 290399001076 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 290399001077 putative FMN binding site [chemical binding]; other site 290399001078 phosphoglucomutase; Validated; Region: PRK07564 290399001079 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 290399001080 active site 290399001081 substrate binding site [chemical binding]; other site 290399001082 metal binding site [ion binding]; metal-binding site 290399001083 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 290399001084 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 290399001085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399001086 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290399001087 Amidase; Region: Amidase; cl11426 290399001088 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 290399001089 active site pocket [active] 290399001090 oxyanion hole [active] 290399001091 catalytic triad [active] 290399001092 active site nucleophile [active] 290399001093 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290399001094 active site residue [active] 290399001095 prephenate dehydratase; Provisional; Region: PRK11898 290399001096 Prephenate dehydratase; Region: PDT; pfam00800 290399001097 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290399001098 putative L-Phe binding site [chemical binding]; other site 290399001099 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290399001100 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290399001101 seryl-tRNA synthetase; Provisional; Region: PRK05431 290399001102 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 290399001103 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 290399001104 dimer interface [polypeptide binding]; other site 290399001105 active site 290399001106 motif 1; other site 290399001107 motif 2; other site 290399001108 motif 3; other site 290399001109 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 290399001110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399001111 active site 290399001112 motif I; other site 290399001113 motif II; other site 290399001114 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290399001115 putative phosphoketolase; Provisional; Region: PRK05261 290399001116 XFP N-terminal domain; Region: XFP_N; pfam09364 290399001117 XFP C-terminal domain; Region: XFP_C; pfam09363 290399001118 Protein of unknown function (DUF429); Region: DUF429; pfam04250 290399001119 Carboxylesterase family; Region: COesterase; pfam00135 290399001120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 290399001121 substrate binding pocket [chemical binding]; other site 290399001122 catalytic triad [active] 290399001123 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 290399001124 dimer interface [polypeptide binding]; other site 290399001125 substrate binding site [chemical binding]; other site 290399001126 metal binding sites [ion binding]; metal-binding site 290399001127 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 290399001128 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 290399001129 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 290399001130 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 290399001131 putative hydrolase; Region: TIGR03624 290399001132 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 290399001133 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 290399001134 Ligand Binding Site [chemical binding]; other site 290399001135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399001136 active site 290399001137 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 290399001138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399001139 Walker A motif; other site 290399001140 ATP binding site [chemical binding]; other site 290399001141 Walker B motif; other site 290399001142 arginine finger; other site 290399001143 Peptidase family M41; Region: Peptidase_M41; pfam01434 290399001144 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 290399001145 homodecamer interface [polypeptide binding]; other site 290399001146 GTP cyclohydrolase I; Provisional; Region: PLN03044 290399001147 active site 290399001148 putative catalytic site residues [active] 290399001149 zinc binding site [ion binding]; other site 290399001150 GTP-CH-I/GFRP interaction surface; other site 290399001151 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 290399001152 dihydropteroate synthase; Region: DHPS; TIGR01496 290399001153 substrate binding pocket [chemical binding]; other site 290399001154 dimer interface [polypeptide binding]; other site 290399001155 inhibitor binding site; inhibition site 290399001156 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 290399001157 homooctamer interface [polypeptide binding]; other site 290399001158 active site 290399001159 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 290399001160 catalytic center binding site [active] 290399001161 ATP binding site [chemical binding]; other site 290399001162 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 290399001163 Uncharacterized conserved protein [Function unknown]; Region: COG3402 290399001164 Bacterial PH domain; Region: DUF304; pfam03703 290399001165 Bacterial PH domain; Region: DUF304; pfam03703 290399001166 Bacterial PH domain; Region: DUF304; pfam03703 290399001167 Rossmann-like domain; Region: Rossmann-like; pfam10727 290399001168 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 290399001169 pantoate--beta-alanine ligase; Region: panC; TIGR00018 290399001170 Pantoate-beta-alanine ligase; Region: PanC; cd00560 290399001171 active site 290399001172 ATP-binding site [chemical binding]; other site 290399001173 pantoate-binding site; other site 290399001174 HXXH motif; other site 290399001175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399001176 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290399001177 putative substrate translocation pore; other site 290399001178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399001179 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399001180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399001181 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 290399001182 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 290399001183 dimer interface [polypeptide binding]; other site 290399001184 putative anticodon binding site; other site 290399001185 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290399001186 motif 1; other site 290399001187 dimer interface [polypeptide binding]; other site 290399001188 active site 290399001189 motif 2; other site 290399001190 motif 3; other site 290399001191 Lsr2; Region: Lsr2; pfam11774 290399001192 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 290399001193 Clp amino terminal domain; Region: Clp_N; pfam02861 290399001194 Clp amino terminal domain; Region: Clp_N; pfam02861 290399001195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399001196 Walker A motif; other site 290399001197 ATP binding site [chemical binding]; other site 290399001198 Walker B motif; other site 290399001199 arginine finger; other site 290399001200 UvrB/uvrC motif; Region: UVR; pfam02151 290399001201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399001202 Walker A motif; other site 290399001203 ATP binding site [chemical binding]; other site 290399001204 Walker B motif; other site 290399001205 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290399001206 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 290399001207 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290399001208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399001209 Coenzyme A binding pocket [chemical binding]; other site 290399001210 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 290399001211 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 290399001212 DAK2 domain; Region: Dak2; cl03685 290399001213 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 290399001214 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290399001215 dimerization domain swap beta strand [polypeptide binding]; other site 290399001216 regulatory protein interface [polypeptide binding]; other site 290399001217 active site 290399001218 regulatory phosphorylation site [posttranslational modification]; other site 290399001219 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 290399001220 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290399001221 endonuclease III; Region: ENDO3c; smart00478 290399001222 minor groove reading motif; other site 290399001223 helix-hairpin-helix signature motif; other site 290399001224 substrate binding pocket [chemical binding]; other site 290399001225 active site 290399001226 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 290399001227 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 290399001228 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399001229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399001230 DNA-binding site [nucleotide binding]; DNA binding site 290399001231 FCD domain; Region: FCD; pfam07729 290399001232 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 290399001233 active site 290399001234 trimer interface [polypeptide binding]; other site 290399001235 allosteric site; other site 290399001236 active site lid [active] 290399001237 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290399001238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399001239 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 290399001240 active site 290399001241 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 290399001242 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 290399001243 putative active site cavity [active] 290399001244 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399001245 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290399001246 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290399001247 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290399001248 inhibitor site; inhibition site 290399001249 active site 290399001250 dimer interface [polypeptide binding]; other site 290399001251 catalytic residue [active] 290399001252 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290399001253 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399001254 Walker A/P-loop; other site 290399001255 ATP binding site [chemical binding]; other site 290399001256 Q-loop/lid; other site 290399001257 ABC transporter signature motif; other site 290399001258 Walker B; other site 290399001259 D-loop; other site 290399001260 H-loop/switch region; other site 290399001261 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399001262 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 290399001263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001264 dimer interface [polypeptide binding]; other site 290399001265 conserved gate region; other site 290399001266 putative PBP binding loops; other site 290399001267 ABC-ATPase subunit interface; other site 290399001268 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290399001269 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399001270 Walker A/P-loop; other site 290399001271 ATP binding site [chemical binding]; other site 290399001272 Q-loop/lid; other site 290399001273 ABC transporter signature motif; other site 290399001274 Walker B; other site 290399001275 D-loop; other site 290399001276 H-loop/switch region; other site 290399001277 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290399001278 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001280 dimer interface [polypeptide binding]; other site 290399001281 conserved gate region; other site 290399001282 putative PBP binding loops; other site 290399001283 ABC-ATPase subunit interface; other site 290399001284 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290399001285 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290399001286 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 290399001287 catalytic site [active] 290399001288 BNR repeat-like domain; Region: BNR_2; pfam13088 290399001289 Asp-box motif; other site 290399001290 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 290399001291 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 290399001292 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 290399001293 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 290399001294 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 290399001295 G1 box; other site 290399001296 putative GEF interaction site [polypeptide binding]; other site 290399001297 GTP/Mg2+ binding site [chemical binding]; other site 290399001298 Switch I region; other site 290399001299 G2 box; other site 290399001300 G3 box; other site 290399001301 Switch II region; other site 290399001302 G4 box; other site 290399001303 G5 box; other site 290399001304 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 290399001305 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399001306 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399001307 active site 290399001308 ATP binding site [chemical binding]; other site 290399001309 substrate binding site [chemical binding]; other site 290399001310 activation loop (A-loop); other site 290399001311 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290399001312 GAF domain; Region: GAF; pfam01590 290399001313 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399001314 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 290399001315 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290399001316 FAD binding pocket [chemical binding]; other site 290399001317 FAD binding motif [chemical binding]; other site 290399001318 phosphate binding motif [ion binding]; other site 290399001319 beta-alpha-beta structure motif; other site 290399001320 NAD binding pocket [chemical binding]; other site 290399001321 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290399001322 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290399001323 catalytic loop [active] 290399001324 iron binding site [ion binding]; other site 290399001325 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290399001326 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290399001327 putative di-iron ligands [ion binding]; other site 290399001328 Methyltransferase domain; Region: Methyltransf_11; pfam08241 290399001329 S-adenosylmethionine binding site [chemical binding]; other site 290399001330 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 290399001331 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399001332 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399001333 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290399001334 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 290399001335 Multicopper oxidase; Region: Cu-oxidase; pfam00394 290399001336 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 290399001337 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 290399001338 Short C-terminal domain; Region: SHOCT; pfam09851 290399001339 DNA repair protein RadA; Provisional; Region: PRK11823 290399001340 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 290399001341 Walker A motif; other site 290399001342 ATP binding site [chemical binding]; other site 290399001343 Walker B motif; other site 290399001344 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290399001345 Predicted membrane protein [Function unknown]; Region: COG4129 290399001346 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290399001347 PBP superfamily domain; Region: PBP_like_2; cl17296 290399001348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001349 dimer interface [polypeptide binding]; other site 290399001350 conserved gate region; other site 290399001351 putative PBP binding loops; other site 290399001352 ABC-ATPase subunit interface; other site 290399001353 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 290399001354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001355 dimer interface [polypeptide binding]; other site 290399001356 conserved gate region; other site 290399001357 putative PBP binding loops; other site 290399001358 ABC-ATPase subunit interface; other site 290399001359 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 290399001360 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 290399001361 Walker A/P-loop; other site 290399001362 ATP binding site [chemical binding]; other site 290399001363 Q-loop/lid; other site 290399001364 ABC transporter signature motif; other site 290399001365 Walker B; other site 290399001366 D-loop; other site 290399001367 H-loop/switch region; other site 290399001368 Phosphate transporter family; Region: PHO4; pfam01384 290399001369 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 290399001370 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 290399001371 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290399001372 P loop; other site 290399001373 Nucleotide binding site [chemical binding]; other site 290399001374 DTAP/Switch II; other site 290399001375 Switch I; other site 290399001376 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290399001377 DTAP/Switch II; other site 290399001378 Switch I; other site 290399001379 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399001380 dimerization interface [polypeptide binding]; other site 290399001381 putative DNA binding site [nucleotide binding]; other site 290399001382 putative Zn2+ binding site [ion binding]; other site 290399001383 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290399001384 arsenical-resistance protein; Region: acr3; TIGR00832 290399001385 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290399001386 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290399001387 active site 290399001388 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290399001389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399001390 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290399001391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290399001392 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290399001393 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290399001394 active site 290399001395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399001396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399001397 putative substrate translocation pore; other site 290399001398 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 290399001399 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 290399001400 putative active site [active] 290399001401 metal binding site [ion binding]; metal-binding site 290399001402 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399001403 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399001404 DNA binding site [nucleotide binding] 290399001405 domain linker motif; other site 290399001406 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290399001407 ligand binding site [chemical binding]; other site 290399001408 dimerization interface (open form) [polypeptide binding]; other site 290399001409 dimerization interface (closed form) [polypeptide binding]; other site 290399001410 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 290399001411 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 290399001412 active site 290399001413 catalytic site [active] 290399001414 ribulokinase; Provisional; Region: PRK04123 290399001415 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 290399001416 N- and C-terminal domain interface [polypeptide binding]; other site 290399001417 active site 290399001418 MgATP binding site [chemical binding]; other site 290399001419 catalytic site [active] 290399001420 metal binding site [ion binding]; metal-binding site 290399001421 carbohydrate binding site [chemical binding]; other site 290399001422 homodimer interface [polypeptide binding]; other site 290399001423 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 290399001424 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 290399001425 intersubunit interface [polypeptide binding]; other site 290399001426 active site 290399001427 Zn2+ binding site [ion binding]; other site 290399001428 L-arabinose isomerase; Provisional; Region: PRK02929 290399001429 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 290399001430 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 290399001431 trimer interface [polypeptide binding]; other site 290399001432 putative substrate binding site [chemical binding]; other site 290399001433 putative metal binding site [ion binding]; other site 290399001434 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290399001435 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290399001436 protein binding site [polypeptide binding]; other site 290399001437 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 290399001438 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 290399001439 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 290399001440 active site 290399001441 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399001442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399001443 DNA binding site [nucleotide binding] 290399001444 domain linker motif; other site 290399001445 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399001446 dimerization interface [polypeptide binding]; other site 290399001447 ligand binding site [chemical binding]; other site 290399001448 Iron permease FTR1 family; Region: FTR1; cl00475 290399001449 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 290399001450 Imelysin; Region: Peptidase_M75; pfam09375 290399001451 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 290399001452 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 290399001453 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290399001454 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 290399001455 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 290399001456 dimer interface [polypeptide binding]; other site 290399001457 NADP binding site [chemical binding]; other site 290399001458 catalytic residues [active] 290399001459 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 290399001460 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290399001461 metal binding site [ion binding]; metal-binding site 290399001462 substrate binding pocket [chemical binding]; other site 290399001463 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399001464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399001465 DNA-binding site [nucleotide binding]; DNA binding site 290399001466 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290399001467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399001468 D-galactonate transporter; Region: 2A0114; TIGR00893 290399001469 putative substrate translocation pore; other site 290399001470 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290399001471 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290399001472 putative substrate binding site [chemical binding]; other site 290399001473 putative ATP binding site [chemical binding]; other site 290399001474 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290399001475 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290399001476 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290399001477 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399001478 active site 290399001479 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290399001480 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 290399001481 alpha-gamma subunit interface [polypeptide binding]; other site 290399001482 beta-gamma subunit interface [polypeptide binding]; other site 290399001483 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 290399001484 gamma-beta subunit interface [polypeptide binding]; other site 290399001485 alpha-beta subunit interface [polypeptide binding]; other site 290399001486 urease subunit alpha; Reviewed; Region: ureC; PRK13207 290399001487 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 290399001488 subunit interactions [polypeptide binding]; other site 290399001489 active site 290399001490 flap region; other site 290399001491 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 290399001492 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 290399001493 dimer interface [polypeptide binding]; other site 290399001494 catalytic residues [active] 290399001495 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 290399001496 UreF; Region: UreF; pfam01730 290399001497 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399001498 UreD urease accessory protein; Region: UreD; cl00530 290399001499 High-affinity nickel-transport protein; Region: NicO; cl00964 290399001500 uncharacterized HhH-GPD family protein; Region: TIGR03252 290399001501 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290399001502 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 290399001503 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 290399001504 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 290399001505 [2Fe-2S] cluster binding site [ion binding]; other site 290399001506 tetracycline repressor protein TetR; Provisional; Region: PRK13756 290399001507 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399001508 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290399001509 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290399001510 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290399001511 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290399001512 active site 290399001513 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399001514 active site 290399001515 metal binding site [ion binding]; metal-binding site 290399001516 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290399001517 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290399001518 putative NAD(P) binding site [chemical binding]; other site 290399001519 putative substrate binding site [chemical binding]; other site 290399001520 catalytic Zn binding site [ion binding]; other site 290399001521 structural Zn binding site [ion binding]; other site 290399001522 dimer interface [polypeptide binding]; other site 290399001523 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 290399001524 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290399001525 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 290399001526 active site 290399001527 catalytic site [active] 290399001528 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 290399001529 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 290399001530 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 290399001531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290399001532 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290399001533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399001534 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 290399001535 putative ADP-binding pocket [chemical binding]; other site 290399001536 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 290399001537 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 290399001538 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399001539 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399001540 active site 290399001541 catalytic tetrad [active] 290399001542 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399001543 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 290399001544 putative NAD(P) binding site [chemical binding]; other site 290399001545 active site 290399001546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399001547 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399001548 active site 290399001549 catalytic tetrad [active] 290399001550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399001551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399001552 active site 290399001553 catalytic tetrad [active] 290399001554 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290399001555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399001556 salt bridge; other site 290399001557 non-specific DNA binding site [nucleotide binding]; other site 290399001558 sequence-specific DNA binding site [nucleotide binding]; other site 290399001559 Dodecin; Region: Dodecin; pfam07311 290399001560 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290399001561 active site 290399001562 catalytic triad [active] 290399001563 oxyanion hole [active] 290399001564 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290399001565 putative homodimer interface [polypeptide binding]; other site 290399001566 putative homotetramer interface [polypeptide binding]; other site 290399001567 putative allosteric switch controlling residues; other site 290399001568 putative metal binding site [ion binding]; other site 290399001569 putative homodimer-homodimer interface [polypeptide binding]; other site 290399001570 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399001571 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399001572 DNA-binding site [nucleotide binding]; DNA binding site 290399001573 FCD domain; Region: FCD; pfam07729 290399001574 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 290399001575 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 290399001576 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399001577 putative transporter; Provisional; Region: PRK09821 290399001578 GntP family permease; Region: GntP_permease; pfam02447 290399001579 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 290399001580 active site 290399001581 intersubunit interface [polypeptide binding]; other site 290399001582 zinc binding site [ion binding]; other site 290399001583 Na+ binding site [ion binding]; other site 290399001584 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 290399001585 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290399001586 Predicted acetyltransferase [General function prediction only]; Region: COG2388 290399001587 GAF domain; Region: GAF; pfam01590 290399001588 ANTAR domain; Region: ANTAR; pfam03861 290399001589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399001590 active site 290399001591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399001592 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290399001593 anti sigma factor interaction site; other site 290399001594 regulatory phosphorylation site [posttranslational modification]; other site 290399001595 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290399001596 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 290399001597 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 290399001598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399001599 catalytic residue [active] 290399001600 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 290399001601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399001602 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 290399001603 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 290399001604 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 290399001605 IucA / IucC family; Region: IucA_IucC; pfam04183 290399001606 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 290399001607 classical (c) SDRs; Region: SDR_c; cd05233 290399001608 NAD(P) binding site [chemical binding]; other site 290399001609 active site 290399001610 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290399001611 proline/glycine betaine transporter; Provisional; Region: PRK10642 290399001612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399001613 putative substrate translocation pore; other site 290399001614 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 290399001615 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 290399001616 nucleotide binding site [chemical binding]; other site 290399001617 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 290399001618 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 290399001619 active site 290399001620 DNA binding site [nucleotide binding] 290399001621 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 290399001622 DNA binding site [nucleotide binding] 290399001623 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 290399001624 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 290399001625 putative DNA binding site [nucleotide binding]; other site 290399001626 putative homodimer interface [polypeptide binding]; other site 290399001627 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 290399001628 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290399001629 putative hydrophobic ligand binding site [chemical binding]; other site 290399001630 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290399001631 dimerization domain swap beta strand [polypeptide binding]; other site 290399001632 regulatory protein interface [polypeptide binding]; other site 290399001633 active site 290399001634 regulatory phosphorylation site [posttranslational modification]; other site 290399001635 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 290399001636 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290399001637 active site 290399001638 phosphorylation site [posttranslational modification] 290399001639 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 290399001640 active site 290399001641 P-loop; other site 290399001642 phosphorylation site [posttranslational modification] 290399001643 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 290399001644 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290399001645 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290399001646 putative substrate binding site [chemical binding]; other site 290399001647 putative ATP binding site [chemical binding]; other site 290399001648 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290399001649 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290399001650 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290399001651 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290399001652 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 290399001653 dimer interface [polypeptide binding]; other site 290399001654 active site 290399001655 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 290399001656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399001657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399001658 DNA binding site [nucleotide binding] 290399001659 domain linker motif; other site 290399001660 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399001661 ligand binding site [chemical binding]; other site 290399001662 dimerization interface [polypeptide binding]; other site 290399001663 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290399001664 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 290399001665 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 290399001666 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290399001667 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290399001668 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290399001669 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 290399001670 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 290399001671 H+ Antiporter protein; Region: 2A0121; TIGR00900 290399001672 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 290399001673 putative active site [active] 290399001674 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 290399001675 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 290399001676 [4Fe-4S] binding site [ion binding]; other site 290399001677 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290399001678 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290399001679 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290399001680 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 290399001681 molybdopterin cofactor binding site; other site 290399001682 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 290399001683 4Fe-4S binding domain; Region: Fer4; cl02805 290399001684 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 290399001685 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 290399001686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399001687 putative substrate translocation pore; other site 290399001688 Protein of unknown function (DUF445); Region: DUF445; pfam04286 290399001689 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 290399001690 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 290399001691 active site 290399001692 catalytic site [active] 290399001693 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 290399001694 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290399001695 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290399001696 Walker A/P-loop; other site 290399001697 ATP binding site [chemical binding]; other site 290399001698 Q-loop/lid; other site 290399001699 ABC transporter signature motif; other site 290399001700 Walker B; other site 290399001701 D-loop; other site 290399001702 H-loop/switch region; other site 290399001703 AzlC protein; Region: AzlC; pfam03591 290399001704 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399001705 GAF domain; Region: GAF; pfam01590 290399001706 GAF domain; Region: GAF_2; pfam13185 290399001707 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399001708 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399001709 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399001710 Domain of unknown function DUF77; Region: DUF77; pfam01910 290399001711 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290399001712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399001713 S-adenosylmethionine binding site [chemical binding]; other site 290399001714 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 290399001715 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 290399001716 dimerization interface [polypeptide binding]; other site 290399001717 DPS ferroxidase diiron center [ion binding]; other site 290399001718 ion pore; other site 290399001719 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290399001720 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399001721 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 290399001722 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290399001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399001724 S-adenosylmethionine binding site [chemical binding]; other site 290399001725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399001726 active site 290399001727 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290399001728 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 290399001729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399001730 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399001731 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290399001732 phosphoenolpyruvate synthase; Validated; Region: PRK06464 290399001733 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290399001734 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290399001735 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290399001736 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 290399001737 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399001738 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399001739 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290399001740 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 290399001741 NodB motif; other site 290399001742 active site 290399001743 catalytic site [active] 290399001744 metal binding site [ion binding]; metal-binding site 290399001745 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 290399001746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399001747 motif II; other site 290399001748 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 290399001749 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290399001750 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290399001751 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290399001752 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 290399001753 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 290399001754 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 290399001755 putative NAD(P) binding site [chemical binding]; other site 290399001756 putative substrate binding site [chemical binding]; other site 290399001757 catalytic Zn binding site [ion binding]; other site 290399001758 structural Zn binding site [ion binding]; other site 290399001759 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399001760 Ligand Binding Site [chemical binding]; other site 290399001761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399001762 Ligand Binding Site [chemical binding]; other site 290399001763 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 290399001764 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 290399001765 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 290399001766 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399001767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399001768 NAD(P) binding site [chemical binding]; other site 290399001769 active site 290399001770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399001771 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290399001772 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 290399001773 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290399001774 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290399001775 putative active site [active] 290399001776 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 290399001777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399001778 active site 290399001779 motif I; other site 290399001780 motif II; other site 290399001781 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290399001782 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290399001783 putative active site [active] 290399001784 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 290399001785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399001786 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 290399001787 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 290399001788 putative ADP-binding pocket [chemical binding]; other site 290399001789 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290399001790 dimer interface [polypeptide binding]; other site 290399001791 active site 290399001792 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290399001793 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 290399001794 substrate binding site [chemical binding]; other site 290399001795 ATP binding site [chemical binding]; other site 290399001796 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 290399001797 active site 290399001798 HIGH motif; other site 290399001799 nucleotide binding site [chemical binding]; other site 290399001800 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290399001801 classical (c) SDRs; Region: SDR_c; cd05233 290399001802 NAD(P) binding site [chemical binding]; other site 290399001803 active site 290399001804 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290399001805 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290399001806 putative active site [active] 290399001807 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399001808 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 290399001809 NAD(P) binding site [chemical binding]; other site 290399001810 catalytic residues [active] 290399001811 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290399001812 substrate binding site [chemical binding]; other site 290399001813 ATP binding site [chemical binding]; other site 290399001814 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 290399001815 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 290399001816 active site 290399001817 nucleotide binding site [chemical binding]; other site 290399001818 HIGH motif; other site 290399001819 KMSKS motif; other site 290399001820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399001821 S-adenosylmethionine binding site [chemical binding]; other site 290399001822 GAF domain; Region: GAF; cl17456 290399001823 GAF domain; Region: GAF_2; pfam13185 290399001824 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399001825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399001826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399001827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290399001828 dimerization interface [polypeptide binding]; other site 290399001829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399001830 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399001831 putative substrate translocation pore; other site 290399001832 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 290399001833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399001834 NAD(P) binding site [chemical binding]; other site 290399001835 active site 290399001836 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290399001837 putative proline-specific permease; Provisional; Region: proY; PRK10580 290399001838 Spore germination protein; Region: Spore_permease; cl17796 290399001839 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290399001840 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399001841 active site 290399001842 short chain dehydrogenase; Provisional; Region: PRK08303 290399001843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399001844 NAD(P) binding site [chemical binding]; other site 290399001845 active site 290399001846 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399001847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399001848 putative DNA binding site [nucleotide binding]; other site 290399001849 putative Zn2+ binding site [ion binding]; other site 290399001850 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399001851 urocanate hydratase; Provisional; Region: PRK05414 290399001852 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290399001853 active sites [active] 290399001854 tetramer interface [polypeptide binding]; other site 290399001855 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 290399001856 putative active site [active] 290399001857 putative metal binding site [ion binding]; other site 290399001858 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290399001859 CopC domain; Region: CopC; pfam04234 290399001860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399001861 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399001862 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399001863 Ligand Binding Site [chemical binding]; other site 290399001864 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290399001865 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290399001866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399001867 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 290399001868 Walker A/P-loop; other site 290399001869 ATP binding site [chemical binding]; other site 290399001870 Q-loop/lid; other site 290399001871 ABC transporter signature motif; other site 290399001872 Walker B; other site 290399001873 D-loop; other site 290399001874 H-loop/switch region; other site 290399001875 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 290399001876 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290399001877 NlpC/P60 family; Region: NLPC_P60; pfam00877 290399001878 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 290399001879 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 290399001880 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290399001881 EamA-like transporter family; Region: EamA; pfam00892 290399001882 EamA-like transporter family; Region: EamA; pfam00892 290399001883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399001884 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399001885 active site 290399001886 transcriptional regulator, ArgP family; Region: argP; TIGR03298 290399001887 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399001888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290399001889 dimerization interface [polypeptide binding]; other site 290399001890 Lysine efflux permease [General function prediction only]; Region: COG1279 290399001891 hypothetical protein; Provisional; Region: PRK07945 290399001892 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 290399001893 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 290399001894 active site 290399001895 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399001896 Ligand Binding Site [chemical binding]; other site 290399001897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399001898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399001899 DNA binding site [nucleotide binding] 290399001900 domain linker motif; other site 290399001901 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290399001902 putative dimerization interface [polypeptide binding]; other site 290399001903 putative ligand binding site [chemical binding]; other site 290399001904 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290399001905 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 290399001906 substrate binding site [chemical binding]; other site 290399001907 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399001908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001909 dimer interface [polypeptide binding]; other site 290399001910 conserved gate region; other site 290399001911 putative PBP binding loops; other site 290399001912 ABC-ATPase subunit interface; other site 290399001913 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290399001914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001915 dimer interface [polypeptide binding]; other site 290399001916 conserved gate region; other site 290399001917 putative PBP binding loops; other site 290399001918 ABC-ATPase subunit interface; other site 290399001919 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290399001920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399001921 Walker A/P-loop; other site 290399001922 ATP binding site [chemical binding]; other site 290399001923 Q-loop/lid; other site 290399001924 ABC transporter signature motif; other site 290399001925 Walker B; other site 290399001926 D-loop; other site 290399001927 H-loop/switch region; other site 290399001928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399001929 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 290399001930 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399001931 Walker A/P-loop; other site 290399001932 ATP binding site [chemical binding]; other site 290399001933 Q-loop/lid; other site 290399001934 ABC transporter signature motif; other site 290399001935 Walker B; other site 290399001936 D-loop; other site 290399001937 H-loop/switch region; other site 290399001938 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399001939 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290399001940 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290399001941 substrate binding [chemical binding]; other site 290399001942 active site 290399001943 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290399001944 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290399001945 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290399001946 active site 290399001947 substrate binding [chemical binding]; other site 290399001948 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290399001949 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 290399001950 active site 290399001951 Asp23 family; Region: Asp23; pfam03780 290399001952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399001953 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 290399001954 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 290399001955 active site 290399001956 catalytic site [active] 290399001957 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290399001958 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 290399001959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399001960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001961 dimer interface [polypeptide binding]; other site 290399001962 conserved gate region; other site 290399001963 putative PBP binding loops; other site 290399001964 ABC-ATPase subunit interface; other site 290399001965 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399001966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399001967 dimer interface [polypeptide binding]; other site 290399001968 conserved gate region; other site 290399001969 putative PBP binding loops; other site 290399001970 ABC-ATPase subunit interface; other site 290399001971 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399001972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399001973 DNA binding site [nucleotide binding] 290399001974 domain linker motif; other site 290399001975 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399001976 dimerization interface [polypeptide binding]; other site 290399001977 ligand binding site [chemical binding]; other site 290399001978 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 290399001979 putative catalytic site [active] 290399001980 putative phosphate binding site [ion binding]; other site 290399001981 active site 290399001982 metal binding site A [ion binding]; metal-binding site 290399001983 DNA binding site [nucleotide binding] 290399001984 putative AP binding site [nucleotide binding]; other site 290399001985 putative metal binding site B [ion binding]; other site 290399001986 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290399001987 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 290399001988 tetrameric interface [polypeptide binding]; other site 290399001989 NAD binding site [chemical binding]; other site 290399001990 catalytic residues [active] 290399001991 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 290399001992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399001993 substrate binding site [chemical binding]; other site 290399001994 oxyanion hole (OAH) forming residues; other site 290399001995 trimer interface [polypeptide binding]; other site 290399001996 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 290399001997 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399001998 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 290399001999 enoyl-CoA hydratase; Provisional; Region: PRK05862 290399002000 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399002001 substrate binding site [chemical binding]; other site 290399002002 oxyanion hole (OAH) forming residues; other site 290399002003 trimer interface [polypeptide binding]; other site 290399002004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399002005 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 290399002006 putative substrate binding site [chemical binding]; other site 290399002007 putative ATP binding site [chemical binding]; other site 290399002008 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290399002009 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290399002010 substrate binding [chemical binding]; other site 290399002011 active site 290399002012 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290399002013 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399002014 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399002015 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399002016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002017 dimer interface [polypeptide binding]; other site 290399002018 conserved gate region; other site 290399002019 putative PBP binding loops; other site 290399002020 ABC-ATPase subunit interface; other site 290399002021 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399002022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002023 dimer interface [polypeptide binding]; other site 290399002024 conserved gate region; other site 290399002025 ABC-ATPase subunit interface; other site 290399002026 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399002027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399002028 DNA binding site [nucleotide binding] 290399002029 domain linker motif; other site 290399002030 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290399002031 putative dimerization interface [polypeptide binding]; other site 290399002032 putative ligand binding site [chemical binding]; other site 290399002033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290399002034 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290399002035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399002036 S-adenosylmethionine binding site [chemical binding]; other site 290399002037 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 290399002038 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399002039 MarR family; Region: MarR; pfam01047 290399002040 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 290399002041 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399002042 acyl-activating enzyme (AAE) consensus motif; other site 290399002043 AMP binding site [chemical binding]; other site 290399002044 active site 290399002045 CoA binding site [chemical binding]; other site 290399002046 acyl-coenzyme A oxidase; Region: PLN02526 290399002047 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399002048 active site 290399002049 RibD C-terminal domain; Region: RibD_C; cl17279 290399002050 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290399002051 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 290399002052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399002053 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290399002054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399002055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399002056 DNA binding residues [nucleotide binding] 290399002057 dimerization interface [polypeptide binding]; other site 290399002058 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 290399002059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399002060 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399002061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399002062 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290399002063 salt bridge; other site 290399002064 non-specific DNA binding site [nucleotide binding]; other site 290399002065 sequence-specific DNA binding site [nucleotide binding]; other site 290399002066 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 290399002067 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 290399002068 YCII-related domain; Region: YCII; cl00999 290399002069 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 290399002070 putative dimer interface [polypeptide binding]; other site 290399002071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399002072 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 290399002073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290399002074 transposase; Provisional; Region: PRK06526 290399002075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399002076 Walker A motif; other site 290399002077 ATP binding site [chemical binding]; other site 290399002078 Walker B motif; other site 290399002079 DNA gyrase, A subunit; Region: gyrA; TIGR01063 290399002080 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399002081 multiple promoter invertase; Provisional; Region: mpi; PRK13413 290399002082 catalytic residues [active] 290399002083 catalytic nucleophile [active] 290399002084 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399002085 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399002086 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399002087 Synaptic Site I dimer interface [polypeptide binding]; other site 290399002088 DNA binding site [nucleotide binding] 290399002089 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 290399002090 DNA-binding interface [nucleotide binding]; DNA binding site 290399002091 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 290399002092 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 290399002093 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 290399002094 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290399002095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399002096 Walker A motif; other site 290399002097 ATP binding site [chemical binding]; other site 290399002098 Walker B motif; other site 290399002099 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 290399002100 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 290399002101 catalytic residues [active] 290399002102 catalytic nucleophile [active] 290399002103 Presynaptic Site I dimer interface [polypeptide binding]; other site 290399002104 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 290399002105 Synaptic Flat tetramer interface [polypeptide binding]; other site 290399002106 Synaptic Site I dimer interface [polypeptide binding]; other site 290399002107 DNA binding site [nucleotide binding] 290399002108 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 290399002109 DNA-binding interface [nucleotide binding]; DNA binding site 290399002110 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290399002111 DNA-binding site [nucleotide binding]; DNA binding site 290399002112 RNA-binding motif; other site 290399002113 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399002114 phosphoenolpyruvate synthase; Validated; Region: PRK06241 290399002115 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290399002116 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290399002117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290399002118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290399002119 metal binding site [ion binding]; metal-binding site 290399002120 active site 290399002121 I-site; other site 290399002122 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 290399002123 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399002124 catalytic Zn binding site [ion binding]; other site 290399002125 NAD(P) binding site [chemical binding]; other site 290399002126 structural Zn binding site [ion binding]; other site 290399002127 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 290399002128 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 290399002129 active site 290399002130 tetramer interface [polypeptide binding]; other site 290399002131 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399002132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002133 dimer interface [polypeptide binding]; other site 290399002134 conserved gate region; other site 290399002135 putative PBP binding loops; other site 290399002136 ABC-ATPase subunit interface; other site 290399002137 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399002138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002139 putative PBP binding loops; other site 290399002140 ABC-ATPase subunit interface; other site 290399002141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399002142 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399002143 extended (e) SDRs; Region: SDR_e; cd08946 290399002144 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399002145 NAD(P) binding site [chemical binding]; other site 290399002146 active site 290399002147 substrate binding site [chemical binding]; other site 290399002148 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399002149 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399002150 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399002151 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399002152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399002153 active site 290399002154 phosphorylation site [posttranslational modification] 290399002155 intermolecular recognition site; other site 290399002156 dimerization interface [polypeptide binding]; other site 290399002157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399002158 DNA binding residues [nucleotide binding] 290399002159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290399002160 Histidine kinase; Region: HisKA_3; pfam07730 290399002161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399002162 ATP binding site [chemical binding]; other site 290399002163 G-X-G motif; other site 290399002164 Domain of unknown function (DUF336); Region: DUF336; cl01249 290399002165 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290399002166 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290399002167 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 290399002168 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 290399002169 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 290399002170 active site 290399002171 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 290399002172 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 290399002173 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399002174 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290399002175 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399002176 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 290399002177 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 290399002178 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 290399002179 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 290399002180 homodimer interface [polypeptide binding]; other site 290399002181 NAD binding pocket [chemical binding]; other site 290399002182 ATP binding pocket [chemical binding]; other site 290399002183 Mg binding site [ion binding]; other site 290399002184 active-site loop [active] 290399002185 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399002186 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399002187 DNA binding site [nucleotide binding] 290399002188 domain linker motif; other site 290399002189 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399002190 dimerization interface [polypeptide binding]; other site 290399002191 ligand binding site [chemical binding]; other site 290399002192 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399002193 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399002194 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399002195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002196 dimer interface [polypeptide binding]; other site 290399002197 conserved gate region; other site 290399002198 putative PBP binding loops; other site 290399002199 ABC-ATPase subunit interface; other site 290399002200 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399002201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002202 dimer interface [polypeptide binding]; other site 290399002203 conserved gate region; other site 290399002204 putative PBP binding loops; other site 290399002205 ABC-ATPase subunit interface; other site 290399002206 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290399002207 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399002208 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399002209 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399002210 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399002211 glucuronate isomerase; Reviewed; Region: PRK02925 290399002212 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 290399002213 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 290399002214 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290399002215 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290399002216 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 290399002217 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 290399002218 metal binding site [ion binding]; metal-binding site 290399002219 substrate binding pocket [chemical binding]; other site 290399002220 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290399002221 ATP-binding site [chemical binding]; other site 290399002222 Gluconate-6-phosphate binding site [chemical binding]; other site 290399002223 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290399002224 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290399002225 hypothetical protein; Provisional; Region: PRK06185 290399002226 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 290399002227 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290399002228 E3 interaction surface; other site 290399002229 lipoyl attachment site [posttranslational modification]; other site 290399002230 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 290399002231 e3 binding domain; Region: E3_binding; pfam02817 290399002232 e3 binding domain; Region: E3_binding; pfam02817 290399002233 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290399002234 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290399002235 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290399002236 alpha subunit interface [polypeptide binding]; other site 290399002237 TPP binding site [chemical binding]; other site 290399002238 heterodimer interface [polypeptide binding]; other site 290399002239 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399002240 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 290399002241 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290399002242 tetramer interface [polypeptide binding]; other site 290399002243 TPP-binding site [chemical binding]; other site 290399002244 heterodimer interface [polypeptide binding]; other site 290399002245 phosphorylation loop region [posttranslational modification] 290399002246 acetyl-CoA synthetase; Provisional; Region: PRK04319 290399002247 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399002248 acyl-activating enzyme (AAE) consensus motif; other site 290399002249 AMP binding site [chemical binding]; other site 290399002250 active site 290399002251 CoA binding site [chemical binding]; other site 290399002252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399002253 active site 290399002254 GAF domain; Region: GAF_2; pfam13185 290399002255 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399002256 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399002257 PGAP1-like protein; Region: PGAP1; pfam07819 290399002258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399002259 UMP phosphatase; Provisional; Region: PRK10444 290399002260 active site 290399002261 motif I; other site 290399002262 motif II; other site 290399002263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399002264 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 290399002265 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 290399002266 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 290399002267 active site 290399002268 intersubunit interface [polypeptide binding]; other site 290399002269 zinc binding site [ion binding]; other site 290399002270 Na+ binding site [ion binding]; other site 290399002271 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 290399002272 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 290399002273 putative uracil binding site [chemical binding]; other site 290399002274 putative active site [active] 290399002275 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290399002276 substrate binding site [chemical binding]; other site 290399002277 THF binding site; other site 290399002278 zinc-binding site [ion binding]; other site 290399002279 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 290399002280 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 290399002281 GDP-binding site [chemical binding]; other site 290399002282 ACT binding site; other site 290399002283 IMP binding site; other site 290399002284 FtsX-like permease family; Region: FtsX; pfam02687 290399002285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290399002286 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290399002287 Walker A/P-loop; other site 290399002288 ATP binding site [chemical binding]; other site 290399002289 Q-loop/lid; other site 290399002290 ABC transporter signature motif; other site 290399002291 Walker B; other site 290399002292 D-loop; other site 290399002293 H-loop/switch region; other site 290399002294 Predicted transcriptional regulators [Transcription]; Region: COG1695 290399002295 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290399002296 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290399002297 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399002298 DNA binding residues [nucleotide binding] 290399002299 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 290399002300 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 290399002301 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290399002302 homodimer interface [polypeptide binding]; other site 290399002303 substrate-cofactor binding pocket; other site 290399002304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399002305 catalytic residue [active] 290399002306 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 290399002307 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 290399002308 active site 290399002309 dimer interface [polypeptide binding]; other site 290399002310 non-prolyl cis peptide bond; other site 290399002311 insertion regions; other site 290399002312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399002313 acetyl-CoA synthetase; Provisional; Region: PRK00174 290399002314 acyl-activating enzyme (AAE) consensus motif; other site 290399002315 AMP binding site [chemical binding]; other site 290399002316 active site 290399002317 CoA binding site [chemical binding]; other site 290399002318 CoA binding domain; Region: CoA_binding; cl17356 290399002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 290399002320 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 290399002321 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290399002322 Protein of unknown function (DUF503); Region: DUF503; pfam04456 290399002323 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 290399002324 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 290399002325 dimerization interface [polypeptide binding]; other site 290399002326 ATP binding site [chemical binding]; other site 290399002327 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 290399002328 dimerization interface [polypeptide binding]; other site 290399002329 ATP binding site [chemical binding]; other site 290399002330 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 290399002331 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 290399002332 putative active site [active] 290399002333 catalytic triad [active] 290399002334 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 290399002335 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 290399002336 catalytic site [active] 290399002337 BNR repeat-like domain; Region: BNR_2; pfam13088 290399002338 Asp-box motif; other site 290399002339 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 290399002340 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 290399002341 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290399002342 active site 290399002343 catalytic residues [active] 290399002344 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 290399002345 PA/protease or protease-like domain interface [polypeptide binding]; other site 290399002346 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 290399002347 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290399002348 catalytic residues [active] 290399002349 Subtilisin inhibitor-like; Region: SSI; cl11594 290399002350 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 290399002351 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 290399002352 active site 290399002353 catalytic triad [active] 290399002354 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 290399002355 PA/protease or protease-like domain interface [polypeptide binding]; other site 290399002356 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290399002357 catalytic residues [active] 290399002358 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290399002359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399002360 putative DNA binding site [nucleotide binding]; other site 290399002361 putative Zn2+ binding site [ion binding]; other site 290399002362 aspartate kinase; Reviewed; Region: PRK06635 290399002363 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 290399002364 putative nucleotide binding site [chemical binding]; other site 290399002365 putative catalytic residues [active] 290399002366 putative Mg ion binding site [ion binding]; other site 290399002367 putative aspartate binding site [chemical binding]; other site 290399002368 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 290399002369 putative allosteric regulatory site; other site 290399002370 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 290399002371 putative allosteric regulatory residue; other site 290399002372 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290399002373 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290399002374 recombination protein RecR; Reviewed; Region: recR; PRK00076 290399002375 RecR protein; Region: RecR; pfam02132 290399002376 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 290399002377 putative active site [active] 290399002378 putative metal-binding site [ion binding]; other site 290399002379 tetramer interface [polypeptide binding]; other site 290399002380 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 290399002381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399002382 Walker A motif; other site 290399002383 ATP binding site [chemical binding]; other site 290399002384 Walker B motif; other site 290399002385 arginine finger; other site 290399002386 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 290399002387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 290399002388 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 290399002389 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290399002390 Peptidase family M23; Region: Peptidase_M23; pfam01551 290399002391 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 290399002392 catalytic residues [active] 290399002393 dimer interface [polypeptide binding]; other site 290399002394 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 290399002395 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 290399002396 NAD binding site [chemical binding]; other site 290399002397 catalytic Zn binding site [ion binding]; other site 290399002398 structural Zn binding site [ion binding]; other site 290399002399 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 290399002400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290399002401 active site 290399002402 metal binding site [ion binding]; metal-binding site 290399002403 hexamer interface [polypeptide binding]; other site 290399002404 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 290399002405 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 290399002406 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290399002407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399002408 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399002409 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 290399002410 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 290399002411 catalytic residues [active] 290399002412 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290399002413 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290399002414 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399002415 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399002416 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 290399002417 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399002418 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290399002419 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399002420 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399002421 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399002422 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399002423 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399002424 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290399002425 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399002426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002427 dimer interface [polypeptide binding]; other site 290399002428 conserved gate region; other site 290399002429 putative PBP binding loops; other site 290399002430 ABC-ATPase subunit interface; other site 290399002431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002432 putative PBP binding loops; other site 290399002433 dimer interface [polypeptide binding]; other site 290399002434 ABC-ATPase subunit interface; other site 290399002435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399002436 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399002437 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399002438 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290399002439 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399002440 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290399002441 nucleotide binding site [chemical binding]; other site 290399002442 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290399002443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399002444 putative substrate translocation pore; other site 290399002445 malate synthase A; Region: malate_syn_A; TIGR01344 290399002446 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290399002447 active site 290399002448 isocitrate lyase; Provisional; Region: PRK15063 290399002449 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290399002450 tetramer interface [polypeptide binding]; other site 290399002451 active site 290399002452 Mg2+/Mn2+ binding site [ion binding]; other site 290399002453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290399002454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399002455 non-specific DNA binding site [nucleotide binding]; other site 290399002456 salt bridge; other site 290399002457 sequence-specific DNA binding site [nucleotide binding]; other site 290399002458 Domain of unknown function (DUF955); Region: DUF955; pfam06114 290399002459 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 290399002460 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 290399002461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399002462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290399002463 dimerization interface [polypeptide binding]; other site 290399002464 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 290399002465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399002466 ATP binding site [chemical binding]; other site 290399002467 Mg2+ binding site [ion binding]; other site 290399002468 G-X-G motif; other site 290399002469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399002470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399002471 active site 290399002472 phosphorylation site [posttranslational modification] 290399002473 intermolecular recognition site; other site 290399002474 dimerization interface [polypeptide binding]; other site 290399002475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399002476 DNA binding site [nucleotide binding] 290399002477 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 290399002478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399002479 putative substrate translocation pore; other site 290399002480 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290399002481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290399002482 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290399002483 pyruvate dehydrogenase; Provisional; Region: PRK06546 290399002484 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 290399002485 PYR/PP interface [polypeptide binding]; other site 290399002486 dimer interface [polypeptide binding]; other site 290399002487 tetramer interface [polypeptide binding]; other site 290399002488 TPP binding site [chemical binding]; other site 290399002489 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399002490 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 290399002491 TPP-binding site [chemical binding]; other site 290399002492 Domain of unknown function (DU1801); Region: DUF1801; cl17490 290399002493 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 290399002494 reactive center loop; other site 290399002495 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290399002496 dimer interface [polypeptide binding]; other site 290399002497 substrate binding site [chemical binding]; other site 290399002498 ATP binding site [chemical binding]; other site 290399002499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399002500 TIGR01777 family protein; Region: yfcH 290399002501 NAD(P) binding site [chemical binding]; other site 290399002502 active site 290399002503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399002504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399002505 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 290399002506 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290399002507 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290399002508 putative active site [active] 290399002509 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290399002510 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 290399002511 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 290399002512 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290399002513 hydrophobic ligand binding site; other site 290399002514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 290399002515 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 290399002516 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 290399002517 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 290399002518 Walker A/P-loop; other site 290399002519 ATP binding site [chemical binding]; other site 290399002520 Q-loop/lid; other site 290399002521 ABC transporter signature motif; other site 290399002522 Walker B; other site 290399002523 D-loop; other site 290399002524 H-loop/switch region; other site 290399002525 TOBE domain; Region: TOBE_2; pfam08402 290399002526 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290399002527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002528 dimer interface [polypeptide binding]; other site 290399002529 conserved gate region; other site 290399002530 putative PBP binding loops; other site 290399002531 ABC-ATPase subunit interface; other site 290399002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002533 dimer interface [polypeptide binding]; other site 290399002534 conserved gate region; other site 290399002535 putative PBP binding loops; other site 290399002536 ABC-ATPase subunit interface; other site 290399002537 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290399002538 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 290399002539 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 290399002540 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 290399002541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399002542 NAD(P) binding site [chemical binding]; other site 290399002543 active site 290399002544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399002545 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290399002546 active site 290399002547 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 290399002548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399002549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399002550 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 290399002551 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 290399002552 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 290399002553 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 290399002554 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290399002555 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290399002556 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 290399002557 probable active site [active] 290399002558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399002559 putative DNA binding site [nucleotide binding]; other site 290399002560 putative Zn2+ binding site [ion binding]; other site 290399002561 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290399002562 hydrophobic ligand binding site; other site 290399002563 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290399002564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399002565 DNA-binding site [nucleotide binding]; DNA binding site 290399002566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399002567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399002568 homodimer interface [polypeptide binding]; other site 290399002569 catalytic residue [active] 290399002570 Predicted membrane protein [Function unknown]; Region: COG2364 290399002571 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 290399002572 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290399002573 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 290399002574 putative DNA binding site [nucleotide binding]; other site 290399002575 catalytic residue [active] 290399002576 putative H2TH interface [polypeptide binding]; other site 290399002577 putative catalytic residues [active] 290399002578 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290399002579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399002580 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 290399002581 ATP binding site [chemical binding]; other site 290399002582 putative Mg++ binding site [ion binding]; other site 290399002583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399002584 nucleotide binding region [chemical binding]; other site 290399002585 ATP-binding site [chemical binding]; other site 290399002586 DEAD/H associated; Region: DEAD_assoc; pfam08494 290399002587 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290399002588 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 290399002589 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290399002590 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 290399002591 iron-sulfur cluster [ion binding]; other site 290399002592 [2Fe-2S] cluster binding site [ion binding]; other site 290399002593 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 290399002594 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 290399002595 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 290399002596 adenylate kinase; Reviewed; Region: adk; PRK00279 290399002597 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290399002598 AMP-binding site [chemical binding]; other site 290399002599 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290399002600 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 290399002601 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290399002602 potential catalytic triad [active] 290399002603 conserved cys residue [active] 290399002604 RibD C-terminal domain; Region: RibD_C; cl17279 290399002605 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399002606 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290399002607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399002608 Coenzyme A binding pocket [chemical binding]; other site 290399002609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399002610 S-adenosylmethionine binding site [chemical binding]; other site 290399002611 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 290399002612 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290399002613 putative NAD(P) binding site [chemical binding]; other site 290399002614 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 290399002615 active site 290399002616 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399002617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290399002618 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290399002619 nucleoside/Zn binding site; other site 290399002620 dimer interface [polypeptide binding]; other site 290399002621 catalytic motif [active] 290399002622 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 290399002623 active site 290399002624 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290399002625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399002626 active site 290399002627 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290399002628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399002629 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 290399002630 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 290399002631 Ligand binding site; other site 290399002632 Ligand binding site; other site 290399002633 Ligand binding site; other site 290399002634 Putative Catalytic site; other site 290399002635 DXD motif; other site 290399002636 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290399002637 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290399002638 catalytic residue [active] 290399002639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399002640 HAMP domain; Region: HAMP; pfam00672 290399002641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399002642 dimer interface [polypeptide binding]; other site 290399002643 phosphorylation site [posttranslational modification] 290399002644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399002645 ATP binding site [chemical binding]; other site 290399002646 Mg2+ binding site [ion binding]; other site 290399002647 G-X-G motif; other site 290399002648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399002649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399002650 active site 290399002651 phosphorylation site [posttranslational modification] 290399002652 intermolecular recognition site; other site 290399002653 dimerization interface [polypeptide binding]; other site 290399002654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399002655 DNA binding site [nucleotide binding] 290399002656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399002657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399002658 DNA binding site [nucleotide binding] 290399002659 Dodecin; Region: Dodecin; pfam07311 290399002660 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399002661 catalytic core [active] 290399002662 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 290399002663 EamA-like transporter family; Region: EamA; pfam00892 290399002664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399002665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399002666 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 290399002667 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 290399002668 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 290399002669 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 290399002670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399002671 Walker A/P-loop; other site 290399002672 ATP binding site [chemical binding]; other site 290399002673 Q-loop/lid; other site 290399002674 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 290399002675 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399002676 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399002677 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399002678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399002679 DNA-binding site [nucleotide binding]; DNA binding site 290399002680 FCD domain; Region: FCD; pfam07729 290399002681 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 290399002682 active site 290399002683 substrate-binding site [chemical binding]; other site 290399002684 metal-binding site [ion binding] 290399002685 GTP binding site [chemical binding]; other site 290399002686 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 290399002687 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 290399002688 heme-binding site [chemical binding]; other site 290399002689 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 290399002690 FAD binding pocket [chemical binding]; other site 290399002691 FAD binding motif [chemical binding]; other site 290399002692 phosphate binding motif [ion binding]; other site 290399002693 beta-alpha-beta structure motif; other site 290399002694 NAD binding pocket [chemical binding]; other site 290399002695 Heme binding pocket [chemical binding]; other site 290399002696 Rrf2 family protein; Region: rrf2_super; TIGR00738 290399002697 Transcriptional regulator; Region: Rrf2; pfam02082 290399002698 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 290399002699 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 290399002700 active site 290399002701 substrate binding site [chemical binding]; other site 290399002702 metal binding site [ion binding]; metal-binding site 290399002703 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290399002704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399002705 ATP binding site [chemical binding]; other site 290399002706 putative Mg++ binding site [ion binding]; other site 290399002707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399002708 nucleotide binding region [chemical binding]; other site 290399002709 ATP-binding site [chemical binding]; other site 290399002710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399002711 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399002712 putative substrate translocation pore; other site 290399002713 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 290399002714 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 290399002715 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290399002716 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 290399002717 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 290399002718 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 290399002719 generic binding surface II; other site 290399002720 generic binding surface I; other site 290399002721 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 290399002722 putative active site [active] 290399002723 putative catalytic site [active] 290399002724 putative Mg binding site IVb [ion binding]; other site 290399002725 putative phosphate binding site [ion binding]; other site 290399002726 putative DNA binding site [nucleotide binding]; other site 290399002727 putative Mg binding site IVa [ion binding]; other site 290399002728 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 290399002729 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 290399002730 putative active site [active] 290399002731 putative metal binding site [ion binding]; other site 290399002732 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290399002733 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399002734 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399002735 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399002736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399002737 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 290399002738 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 290399002739 NAD(P) binding site [chemical binding]; other site 290399002740 Predicted transcriptional regulators [Transcription]; Region: COG1695 290399002741 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290399002742 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 290399002743 Carbon starvation protein CstA; Region: CstA; pfam02554 290399002744 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 290399002745 Protein of unknown function (DUF466); Region: DUF466; pfam04328 290399002746 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 290399002747 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399002748 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399002749 active site 290399002750 catalytic tetrad [active] 290399002751 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 290399002752 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290399002753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399002754 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290399002755 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399002756 motif II; other site 290399002757 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290399002758 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 290399002759 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 290399002760 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399002761 active site 290399002762 nucleotide binding site [chemical binding]; other site 290399002763 HIGH motif; other site 290399002764 KMSKS motif; other site 290399002765 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 290399002766 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 290399002767 nudix motif; other site 290399002768 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 290399002769 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 290399002770 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 290399002771 Helicase associated domain; Region: HA; pfam03457 290399002772 Family of unknown function (DUF695); Region: DUF695; pfam05117 290399002773 Nuclease-related domain; Region: NERD; pfam08378 290399002774 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 290399002775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399002776 motif II; other site 290399002777 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290399002778 TAP-like protein; Region: Abhydrolase_4; pfam08386 290399002779 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399002780 DNA polymerase III subunit delta'; Validated; Region: PRK07940 290399002781 DNA polymerase III subunit delta'; Validated; Region: PRK08485 290399002782 thymidylate kinase; Validated; Region: tmk; PRK00698 290399002783 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 290399002784 TMP-binding site; other site 290399002785 ATP-binding site [chemical binding]; other site 290399002786 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 290399002787 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290399002788 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399002789 catalytic residue [active] 290399002790 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 290399002791 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399002792 catalytic core [active] 290399002793 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 290399002794 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290399002795 PhoU domain; Region: PhoU; pfam01895 290399002796 PhoU domain; Region: PhoU; pfam01895 290399002797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399002798 dimer interface [polypeptide binding]; other site 290399002799 phosphorylation site [posttranslational modification] 290399002800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399002801 ATP binding site [chemical binding]; other site 290399002802 Mg2+ binding site [ion binding]; other site 290399002803 G-X-G motif; other site 290399002804 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399002805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399002806 active site 290399002807 phosphorylation site [posttranslational modification] 290399002808 intermolecular recognition site; other site 290399002809 dimerization interface [polypeptide binding]; other site 290399002810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399002811 DNA binding site [nucleotide binding] 290399002812 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 290399002813 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 290399002814 substrate binding site; other site 290399002815 dimer interface; other site 290399002816 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 290399002817 zinc binding site [ion binding]; other site 290399002818 homotrimer interaction site [polypeptide binding]; other site 290399002819 CDP-binding sites; other site 290399002820 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290399002821 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399002822 active site 290399002823 HIGH motif; other site 290399002824 nucleotide binding site [chemical binding]; other site 290399002825 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290399002826 KMSKS motif; other site 290399002827 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290399002828 tRNA binding surface [nucleotide binding]; other site 290399002829 anticodon binding site; other site 290399002830 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290399002831 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 290399002832 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290399002833 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290399002834 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 290399002835 putative active site [active] 290399002836 catalytic triad [active] 290399002837 putative dimer interface [polypeptide binding]; other site 290399002838 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 290399002839 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290399002840 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290399002841 active site 290399002842 catalytic site [active] 290399002843 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 290399002844 active site 290399002845 barstar interaction site; other site 290399002846 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 290399002847 putative RNAase interaction site [polypeptide binding]; other site 290399002848 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 290399002849 putative homodimer interface [polypeptide binding]; other site 290399002850 putative active site pocket [active] 290399002851 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 290399002852 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 290399002853 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 290399002854 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290399002855 active site 290399002856 homodimer interface [polypeptide binding]; other site 290399002857 catalytic site [active] 290399002858 acceptor binding site [chemical binding]; other site 290399002859 trehalose synthase; Region: treS_nterm; TIGR02456 290399002860 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 290399002861 active site 290399002862 catalytic site [active] 290399002863 glycogen branching enzyme; Provisional; Region: PRK14705 290399002864 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 290399002865 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 290399002866 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 290399002867 active site 290399002868 catalytic site [active] 290399002869 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 290399002870 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290399002871 hydrophobic ligand binding site; other site 290399002872 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290399002873 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290399002874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399002875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399002876 DNA binding site [nucleotide binding] 290399002877 domain linker motif; other site 290399002878 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399002879 dimerization interface [polypeptide binding]; other site 290399002880 ligand binding site [chemical binding]; other site 290399002881 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 290399002882 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290399002883 active site 290399002884 catalytic site [active] 290399002885 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399002886 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290399002887 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290399002888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002889 dimer interface [polypeptide binding]; other site 290399002890 conserved gate region; other site 290399002891 ABC-ATPase subunit interface; other site 290399002892 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399002893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399002894 dimer interface [polypeptide binding]; other site 290399002895 conserved gate region; other site 290399002896 putative PBP binding loops; other site 290399002897 ABC-ATPase subunit interface; other site 290399002898 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 290399002899 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290399002900 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 290399002901 active site 290399002902 homodimer interface [polypeptide binding]; other site 290399002903 catalytic site [active] 290399002904 FAD binding domain; Region: FAD_binding_4; pfam01565 290399002905 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 290399002906 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 290399002907 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 290399002908 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 290399002909 Walker A/P-loop; other site 290399002910 ATP binding site [chemical binding]; other site 290399002911 Q-loop/lid; other site 290399002912 ABC transporter signature motif; other site 290399002913 Walker B; other site 290399002914 D-loop; other site 290399002915 H-loop/switch region; other site 290399002916 TOBE domain; Region: TOBE_2; pfam08402 290399002917 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 290399002918 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 290399002919 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 290399002920 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 290399002921 active site 290399002922 homotetramer interface [polypeptide binding]; other site 290399002923 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 290399002924 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 290399002925 catalytic residues [active] 290399002926 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 290399002927 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290399002928 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290399002929 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 290399002930 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 290399002931 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 290399002932 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 290399002933 active site 290399002934 catalytic triad [active] 290399002935 dimer interface [polypeptide binding]; other site 290399002936 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 290399002937 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 290399002938 dimerization interface [polypeptide binding]; other site 290399002939 DPS ferroxidase diiron center [ion binding]; other site 290399002940 ion pore; other site 290399002941 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 290399002942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399002943 putative substrate translocation pore; other site 290399002944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399002945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399002946 glycine dehydrogenase; Provisional; Region: PRK05367 290399002947 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290399002948 tetramer interface [polypeptide binding]; other site 290399002949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399002950 catalytic residue [active] 290399002951 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290399002952 tetramer interface [polypeptide binding]; other site 290399002953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399002954 catalytic residue [active] 290399002955 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290399002956 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290399002957 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290399002958 lipoyl attachment site [posttranslational modification]; other site 290399002959 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290399002960 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290399002961 dimer interface [polypeptide binding]; other site 290399002962 active site 290399002963 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290399002964 folate binding site [chemical binding]; other site 290399002965 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290399002966 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290399002967 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290399002968 TspO/MBR family; Region: TspO_MBR; pfam03073 290399002969 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 290399002970 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 290399002971 active site 290399002972 substrate binding site [chemical binding]; other site 290399002973 Mg2+ binding site [ion binding]; other site 290399002974 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 290399002975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 290399002976 Uncharacterized conserved protein [Function unknown]; Region: COG2966 290399002977 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 290399002978 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290399002979 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290399002980 FAD binding pocket [chemical binding]; other site 290399002981 FAD binding motif [chemical binding]; other site 290399002982 phosphate binding motif [ion binding]; other site 290399002983 NAD binding pocket [chemical binding]; other site 290399002984 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 290399002985 ligand binding site [chemical binding]; other site 290399002986 active site 290399002987 UGI interface [polypeptide binding]; other site 290399002988 catalytic site [active] 290399002989 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 290399002990 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290399002991 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290399002992 DNA-binding site [nucleotide binding]; DNA binding site 290399002993 RNA-binding motif; other site 290399002994 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 290399002995 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290399002996 ligand binding site [chemical binding]; other site 290399002997 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290399002998 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290399002999 ring oligomerisation interface [polypeptide binding]; other site 290399003000 ATP/Mg binding site [chemical binding]; other site 290399003001 stacking interactions; other site 290399003002 hinge regions; other site 290399003003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399003004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399003005 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 290399003006 RNA/DNA hybrid binding site [nucleotide binding]; other site 290399003007 active site 290399003008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 290399003009 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 290399003010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399003011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290399003012 dimerization interface [polypeptide binding]; other site 290399003013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399003014 dimer interface [polypeptide binding]; other site 290399003015 phosphorylation site [posttranslational modification] 290399003016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399003017 ATP binding site [chemical binding]; other site 290399003018 Mg2+ binding site [ion binding]; other site 290399003019 G-X-G motif; other site 290399003020 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399003021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399003022 active site 290399003023 phosphorylation site [posttranslational modification] 290399003024 intermolecular recognition site; other site 290399003025 dimerization interface [polypeptide binding]; other site 290399003026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399003027 DNA binding site [nucleotide binding] 290399003028 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 290399003029 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 290399003030 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290399003031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399003032 ATP binding site [chemical binding]; other site 290399003033 putative Mg++ binding site [ion binding]; other site 290399003034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399003035 nucleotide binding region [chemical binding]; other site 290399003036 ATP-binding site [chemical binding]; other site 290399003037 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 290399003038 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290399003039 DNA-binding site [nucleotide binding]; DNA binding site 290399003040 RNA-binding motif; other site 290399003041 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 290399003042 H+ Antiporter protein; Region: 2A0121; TIGR00900 290399003043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003044 putative substrate translocation pore; other site 290399003045 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290399003046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399003047 catalytic residue [active] 290399003048 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290399003049 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 290399003050 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290399003051 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 290399003052 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290399003053 Peptidase family M23; Region: Peptidase_M23; pfam01551 290399003054 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 290399003055 NlpC/P60 family; Region: NLPC_P60; pfam00877 290399003056 NlpC/P60 family; Region: NLPC_P60; cl17555 290399003057 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 290399003058 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399003059 active site 290399003060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399003061 active site 290399003062 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290399003063 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290399003064 dimer interface [polypeptide binding]; other site 290399003065 putative functional site; other site 290399003066 putative MPT binding site; other site 290399003067 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 290399003068 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 290399003069 active site 290399003070 catalytic site [active] 290399003071 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 290399003072 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 290399003073 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290399003074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399003075 Walker A/P-loop; other site 290399003076 ATP binding site [chemical binding]; other site 290399003077 Q-loop/lid; other site 290399003078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399003079 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399003080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399003081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399003082 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399003083 Walker A/P-loop; other site 290399003084 ATP binding site [chemical binding]; other site 290399003085 Q-loop/lid; other site 290399003086 ABC transporter signature motif; other site 290399003087 Walker B; other site 290399003088 D-loop; other site 290399003089 H-loop/switch region; other site 290399003090 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 290399003091 nudix motif; other site 290399003092 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 290399003093 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290399003094 active site 290399003095 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 290399003096 Part of AAA domain; Region: AAA_19; pfam13245 290399003097 Family description; Region: UvrD_C_2; pfam13538 290399003098 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290399003099 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 290399003100 CoA-ligase; Region: Ligase_CoA; pfam00549 290399003101 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290399003102 CoA binding domain; Region: CoA_binding; smart00881 290399003103 CoA binding domain; Region: CoA_binding; cl17356 290399003104 CoA-ligase; Region: Ligase_CoA; pfam00549 290399003105 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 290399003106 putative hydrophobic ligand binding site [chemical binding]; other site 290399003107 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399003108 putative DNA binding site [nucleotide binding]; other site 290399003109 putative Zn2+ binding site [ion binding]; other site 290399003110 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 290399003111 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290399003112 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399003113 substrate binding site [chemical binding]; other site 290399003114 ATP binding site [chemical binding]; other site 290399003115 Class I aldolases; Region: Aldolase_Class_I; cl17187 290399003116 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 290399003117 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290399003118 PYR/PP interface [polypeptide binding]; other site 290399003119 dimer interface [polypeptide binding]; other site 290399003120 TPP binding site [chemical binding]; other site 290399003121 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399003122 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 290399003123 TPP-binding site; other site 290399003124 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290399003125 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 290399003126 tetrameric interface [polypeptide binding]; other site 290399003127 NAD binding site [chemical binding]; other site 290399003128 catalytic residues [active] 290399003129 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399003130 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399003131 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399003132 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399003133 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 290399003134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003135 putative substrate translocation pore; other site 290399003136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003137 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399003138 MarR family; Region: MarR_2; cl17246 290399003139 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290399003140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003141 putative substrate translocation pore; other site 290399003142 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 290399003143 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290399003144 putative ligand binding site [chemical binding]; other site 290399003145 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399003146 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399003147 TM-ABC transporter signature motif; other site 290399003148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290399003149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399003150 Walker A/P-loop; other site 290399003151 ATP binding site [chemical binding]; other site 290399003152 Q-loop/lid; other site 290399003153 ABC transporter signature motif; other site 290399003154 Walker B; other site 290399003155 D-loop; other site 290399003156 H-loop/switch region; other site 290399003157 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399003158 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399003159 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399003160 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399003161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399003162 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399003163 KduI/IolB family; Region: KduI; pfam04962 290399003164 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290399003165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399003166 DNA-binding site [nucleotide binding]; DNA binding site 290399003167 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290399003168 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 290399003169 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 290399003170 catalytic triad [active] 290399003171 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290399003172 hydrophobic ligand binding site; other site 290399003173 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399003174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399003175 DNA-binding site [nucleotide binding]; DNA binding site 290399003176 FCD domain; Region: FCD; pfam07729 290399003177 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 290399003178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003179 putative substrate translocation pore; other site 290399003180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399003181 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290399003182 NAD(P) binding site [chemical binding]; other site 290399003183 active site 290399003184 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290399003185 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 290399003186 active site 290399003187 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 290399003188 diiron binding motif [ion binding]; other site 290399003189 CCC1-related family of proteins; Region: CCC1_like; cl00278 290399003190 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 290399003191 Na binding site [ion binding]; other site 290399003192 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290399003193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399003194 non-specific DNA binding site [nucleotide binding]; other site 290399003195 salt bridge; other site 290399003196 sequence-specific DNA binding site [nucleotide binding]; other site 290399003197 Cupin domain; Region: Cupin_2; pfam07883 290399003198 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 290399003199 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 290399003200 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290399003201 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 290399003202 agmatinase; Region: agmatinase; TIGR01230 290399003203 oligomer interface [polypeptide binding]; other site 290399003204 putative active site [active] 290399003205 Mn binding site [ion binding]; other site 290399003206 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 290399003207 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290399003208 PYR/PP interface [polypeptide binding]; other site 290399003209 dimer interface [polypeptide binding]; other site 290399003210 TPP binding site [chemical binding]; other site 290399003211 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399003212 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290399003213 TPP-binding site [chemical binding]; other site 290399003214 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399003215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399003216 putative DNA binding site [nucleotide binding]; other site 290399003217 putative Zn2+ binding site [ion binding]; other site 290399003218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003219 putative substrate translocation pore; other site 290399003220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003221 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 290399003222 active site 290399003223 putative catalytic site [active] 290399003224 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399003225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399003226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399003227 Walker A/P-loop; other site 290399003228 ATP binding site [chemical binding]; other site 290399003229 Q-loop/lid; other site 290399003230 ABC transporter signature motif; other site 290399003231 Walker B; other site 290399003232 D-loop; other site 290399003233 H-loop/switch region; other site 290399003234 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399003235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399003236 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 290399003237 Walker A/P-loop; other site 290399003238 ATP binding site [chemical binding]; other site 290399003239 Q-loop/lid; other site 290399003240 ABC transporter signature motif; other site 290399003241 Walker B; other site 290399003242 D-loop; other site 290399003243 H-loop/switch region; other site 290399003244 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290399003245 active site 290399003246 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290399003247 PspC domain; Region: PspC; pfam04024 290399003248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399003249 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290399003250 Walker A motif; other site 290399003251 ATP binding site [chemical binding]; other site 290399003252 Walker B motif; other site 290399003253 arginine finger; other site 290399003254 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 290399003255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399003256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399003257 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 290399003258 PAS fold; Region: PAS_4; pfam08448 290399003259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399003260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399003261 dimer interface [polypeptide binding]; other site 290399003262 phosphorylation site [posttranslational modification] 290399003263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399003264 ATP binding site [chemical binding]; other site 290399003265 Mg2+ binding site [ion binding]; other site 290399003266 G-X-G motif; other site 290399003267 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399003268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399003269 active site 290399003270 phosphorylation site [posttranslational modification] 290399003271 intermolecular recognition site; other site 290399003272 dimerization interface [polypeptide binding]; other site 290399003273 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399003274 DNA binding site [nucleotide binding] 290399003275 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290399003276 active site 290399003277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399003278 sequence-specific DNA binding site [nucleotide binding]; other site 290399003279 salt bridge; other site 290399003280 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 290399003281 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 290399003282 additional DNA contacts [nucleotide binding]; other site 290399003283 mismatch recognition site; other site 290399003284 active site 290399003285 zinc binding site [ion binding]; other site 290399003286 DNA intercalation site [nucleotide binding]; other site 290399003287 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 290399003288 biotin synthase; Validated; Region: PRK06256 290399003289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399003290 FeS/SAM binding site; other site 290399003291 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 290399003292 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 290399003293 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 290399003294 SnoaL-like domain; Region: SnoaL_2; pfam12680 290399003295 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 290399003296 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290399003297 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 290399003298 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399003299 putative NAD(P) binding site [chemical binding]; other site 290399003300 catalytic Zn binding site [ion binding]; other site 290399003301 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290399003302 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290399003303 FMN binding site [chemical binding]; other site 290399003304 active site 290399003305 substrate binding site [chemical binding]; other site 290399003306 catalytic residue [active] 290399003307 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399003308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399003309 DNA-binding site [nucleotide binding]; DNA binding site 290399003310 FCD domain; Region: FCD; pfam07729 290399003311 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290399003312 dihydroxyacetone kinase; Provisional; Region: PRK14479 290399003313 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290399003314 DAK2 domain; Region: Dak2; pfam02734 290399003315 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 290399003316 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 290399003317 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290399003318 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290399003319 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290399003320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399003321 NAD(P) binding site [chemical binding]; other site 290399003322 active site 290399003323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399003325 putative substrate translocation pore; other site 290399003326 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290399003327 substrate binding site [chemical binding]; other site 290399003328 dimer interface [polypeptide binding]; other site 290399003329 catalytic triad [active] 290399003330 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 290399003331 RNase_H superfamily; Region: RNase_H_2; pfam13482 290399003332 Part of AAA domain; Region: AAA_19; pfam13245 290399003333 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290399003334 AAA domain; Region: AAA_12; pfam13087 290399003335 SOUL heme-binding protein; Region: SOUL; pfam04832 290399003336 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290399003337 nucleoside/Zn binding site; other site 290399003338 dimer interface [polypeptide binding]; other site 290399003339 catalytic motif [active] 290399003340 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 290399003341 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 290399003342 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 290399003343 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290399003344 RNA binding site [nucleotide binding]; other site 290399003345 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 290399003346 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 290399003347 Cupin domain; Region: Cupin_2; cl17218 290399003348 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 290399003349 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290399003350 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290399003351 tetramer interface [polypeptide binding]; other site 290399003352 active site 290399003353 Mg2+/Mn2+ binding site [ion binding]; other site 290399003354 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 290399003355 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 290399003356 putative NAD(P) binding site [chemical binding]; other site 290399003357 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290399003358 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 290399003359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290399003360 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290399003361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399003362 ABC transporter signature motif; other site 290399003363 Walker B; other site 290399003364 D-loop; other site 290399003365 H-loop/switch region; other site 290399003366 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290399003367 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 290399003368 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 290399003369 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 290399003370 active site 290399003371 purine riboside binding site [chemical binding]; other site 290399003372 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290399003373 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290399003374 putative molybdopterin cofactor binding site [chemical binding]; other site 290399003375 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290399003376 putative molybdopterin cofactor binding site; other site 290399003377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399003378 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399003379 active site 290399003380 catalytic tetrad [active] 290399003381 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 290399003382 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399003383 TAP-like protein; Region: Abhydrolase_4; pfam08386 290399003384 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 290399003385 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 290399003386 Ca binding site [ion binding]; other site 290399003387 active site 290399003388 catalytic site [active] 290399003389 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290399003390 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290399003391 acylphosphatase; Provisional; Region: PRK14427 290399003392 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290399003393 Predicted acetyltransferase [General function prediction only]; Region: COG2388 290399003394 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 290399003395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290399003396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399003397 salt bridge; other site 290399003398 non-specific DNA binding site [nucleotide binding]; other site 290399003399 sequence-specific DNA binding site [nucleotide binding]; other site 290399003400 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 290399003401 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 290399003402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399003404 putative substrate translocation pore; other site 290399003405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003406 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 290399003407 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 290399003408 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 290399003409 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290399003410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003411 putative substrate translocation pore; other site 290399003412 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 290399003413 Leucine carboxyl methyltransferase; Region: LCM; cl01306 290399003414 GYD domain; Region: GYD; pfam08734 290399003415 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 290399003416 Protein of unknown function (DUF664); Region: DUF664; pfam04978 290399003417 DinB superfamily; Region: DinB_2; pfam12867 290399003418 Protein of unknown function (DUF664); Region: DUF664; pfam04978 290399003419 DinB superfamily; Region: DinB_2; pfam12867 290399003420 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290399003421 putative hydrophobic ligand binding site [chemical binding]; other site 290399003422 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399003423 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 290399003424 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290399003425 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 290399003426 acyl-activating enzyme (AAE) consensus motif; other site 290399003427 putative AMP binding site [chemical binding]; other site 290399003428 putative active site [active] 290399003429 putative CoA binding site [chemical binding]; other site 290399003430 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290399003431 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290399003432 putative switch regulator; other site 290399003433 Penicillinase repressor; Region: Pencillinase_R; cl17580 290399003434 non-specific DNA interactions [nucleotide binding]; other site 290399003435 DNA binding site [nucleotide binding] 290399003436 sequence specific DNA binding site [nucleotide binding]; other site 290399003437 putative cAMP binding site [chemical binding]; other site 290399003438 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 290399003439 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290399003440 Domain of unknown function DUF21; Region: DUF21; pfam01595 290399003441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290399003442 Transporter associated domain; Region: CorC_HlyC; smart01091 290399003443 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290399003444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399003445 ATP binding site [chemical binding]; other site 290399003446 putative Mg++ binding site [ion binding]; other site 290399003447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399003448 nucleotide binding region [chemical binding]; other site 290399003449 ATP-binding site [chemical binding]; other site 290399003450 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 290399003451 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 290399003452 active site 290399003453 catalytic site [active] 290399003454 metal binding site [ion binding]; metal-binding site 290399003455 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 290399003456 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 290399003457 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399003458 Excalibur calcium-binding domain; Region: Excalibur; smart00894 290399003459 H+ Antiporter protein; Region: 2A0121; TIGR00900 290399003460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003461 putative substrate translocation pore; other site 290399003462 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 290399003463 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 290399003464 ATP binding site [chemical binding]; other site 290399003465 substrate interface [chemical binding]; other site 290399003466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290399003467 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290399003468 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 290399003469 FAD binding domain; Region: FAD_binding_2; pfam00890 290399003470 Ion channel; Region: Ion_trans_2; pfam07885 290399003471 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 290399003472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003473 putative substrate translocation pore; other site 290399003474 Protein of unknown function (DUF998); Region: DUF998; pfam06197 290399003475 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290399003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399003477 S-adenosylmethionine binding site [chemical binding]; other site 290399003478 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290399003479 putative lipid kinase; Reviewed; Region: PRK13057 290399003480 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399003481 Ligand Binding Site [chemical binding]; other site 290399003482 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 290399003483 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290399003484 dimer interface [polypeptide binding]; other site 290399003485 PYR/PP interface [polypeptide binding]; other site 290399003486 TPP binding site [chemical binding]; other site 290399003487 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399003488 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290399003489 TPP-binding site [chemical binding]; other site 290399003490 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399003491 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290399003492 AsnC family; Region: AsnC_trans_reg; pfam01037 290399003493 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 290399003494 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399003495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399003496 homodimer interface [polypeptide binding]; other site 290399003497 catalytic residue [active] 290399003498 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290399003499 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 290399003500 PLD-like domain; Region: PLDc_2; pfam13091 290399003501 putative homodimer interface [polypeptide binding]; other site 290399003502 putative active site [active] 290399003503 catalytic site [active] 290399003504 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290399003505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399003506 ATP binding site [chemical binding]; other site 290399003507 putative Mg++ binding site [ion binding]; other site 290399003508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399003509 nucleotide binding region [chemical binding]; other site 290399003510 ATP-binding site [chemical binding]; other site 290399003511 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 290399003512 DNA-sulfur modification-associated; Region: DndB; cl17621 290399003513 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 290399003514 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 290399003515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290399003516 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 290399003517 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290399003518 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 290399003519 HsdM N-terminal domain; Region: HsdM_N; pfam12161 290399003520 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290399003521 Methyltransferase domain; Region: Methyltransf_26; pfam13659 290399003522 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399003523 active site 290399003524 catalytic residues [active] 290399003525 DNA binding site [nucleotide binding] 290399003526 Int/Topo IB signature motif; other site 290399003527 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290399003528 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 290399003529 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399003530 active site 290399003531 catalytic residues [active] 290399003532 DNA binding site [nucleotide binding] 290399003533 Int/Topo IB signature motif; other site 290399003534 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 290399003535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 290399003536 Helicase associated domain; Region: HA; pfam03457 290399003537 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 290399003538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399003539 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399003540 active site 290399003541 ATP binding site [chemical binding]; other site 290399003542 substrate binding site [chemical binding]; other site 290399003543 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290399003544 substrate binding site [chemical binding]; other site 290399003545 activation loop (A-loop); other site 290399003546 activation loop (A-loop); other site 290399003547 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 290399003548 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290399003549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399003550 Coenzyme A binding pocket [chemical binding]; other site 290399003551 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 290399003552 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399003553 substrate binding site [chemical binding]; other site 290399003554 dimer interface [polypeptide binding]; other site 290399003555 ATP binding site [chemical binding]; other site 290399003556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399003558 putative substrate translocation pore; other site 290399003559 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 290399003560 active site 290399003561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290399003562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399003563 DNA-binding site [nucleotide binding]; DNA binding site 290399003564 UTRA domain; Region: UTRA; cl17743 290399003565 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399003566 active site 290399003567 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 290399003568 pentamer interface [polypeptide binding]; other site 290399003569 dodecaamer interface [polypeptide binding]; other site 290399003570 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 290399003571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399003572 FeS/SAM binding site; other site 290399003573 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 290399003574 Ycf46; Provisional; Region: ycf46; CHL00195 290399003575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399003576 Walker A motif; other site 290399003577 ATP binding site [chemical binding]; other site 290399003578 Walker B motif; other site 290399003579 arginine finger; other site 290399003580 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290399003581 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290399003582 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399003583 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290399003584 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290399003585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399003586 S-adenosylmethionine binding site [chemical binding]; other site 290399003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290399003588 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290399003589 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290399003590 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 290399003591 active site 290399003592 YciI-like protein; Reviewed; Region: PRK12866 290399003593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399003594 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399003595 SnoaL-like domain; Region: SnoaL_2; pfam12680 290399003596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399003597 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290399003598 NAD(P) binding site [chemical binding]; other site 290399003599 active site 290399003600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399003601 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290399003602 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290399003603 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290399003604 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 290399003605 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 290399003606 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 290399003607 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290399003608 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290399003609 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399003610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399003611 dimer interface [polypeptide binding]; other site 290399003612 conserved gate region; other site 290399003613 putative PBP binding loops; other site 290399003614 ABC-ATPase subunit interface; other site 290399003615 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 290399003616 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290399003617 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399003618 Walker A/P-loop; other site 290399003619 ATP binding site [chemical binding]; other site 290399003620 Q-loop/lid; other site 290399003621 ABC transporter signature motif; other site 290399003622 Walker B; other site 290399003623 D-loop; other site 290399003624 H-loop/switch region; other site 290399003625 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399003626 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 290399003627 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399003628 Walker A/P-loop; other site 290399003629 ATP binding site [chemical binding]; other site 290399003630 Q-loop/lid; other site 290399003631 ABC transporter signature motif; other site 290399003632 Walker B; other site 290399003633 D-loop; other site 290399003634 H-loop/switch region; other site 290399003635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399003636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399003637 active site 290399003638 catalytic tetrad [active] 290399003639 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 290399003640 BNR repeat-like domain; Region: BNR_2; pfam13088 290399003641 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 290399003642 Asp-box motif; other site 290399003643 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 290399003644 classical (c) SDRs; Region: SDR_c; cd05233 290399003645 NAD(P) binding site [chemical binding]; other site 290399003646 active site 290399003647 PhoD-like phosphatase; Region: PhoD; pfam09423 290399003648 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290399003649 putative active site [active] 290399003650 putative metal binding site [ion binding]; other site 290399003651 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290399003652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399003653 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290399003654 Hemerythrin-like domain; Region: Hr-like; cd12108 290399003655 Fe binding site [ion binding]; other site 290399003656 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290399003657 active site 290399003658 catalytic residues [active] 290399003659 Lipase (class 2); Region: Lipase_2; pfam01674 290399003660 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399003661 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290399003662 active site 290399003663 catalytic residues [active] 290399003664 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290399003665 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290399003666 phosphopeptide binding site; other site 290399003667 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290399003668 DNA-binding site [nucleotide binding]; DNA binding site 290399003669 RNA-binding motif; other site 290399003670 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 290399003671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290399003672 binding surface 290399003673 TPR motif; other site 290399003674 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 290399003675 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290399003676 putative active site [active] 290399003677 putative metal binding site [ion binding]; other site 290399003678 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290399003679 putative oxidoreductase; Provisional; Region: PRK11579 290399003680 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399003681 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399003682 Methyltransferase domain; Region: Methyltransf_11; pfam08241 290399003683 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399003684 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 290399003685 active site 290399003686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399003687 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 290399003688 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 290399003689 oxidoreductase; Provisional; Region: PRK06128 290399003690 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 290399003691 NAD binding site [chemical binding]; other site 290399003692 metal binding site [ion binding]; metal-binding site 290399003693 active site 290399003694 short chain dehydrogenase; Provisional; Region: PRK06197 290399003695 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 290399003696 putative NAD(P) binding site [chemical binding]; other site 290399003697 active site 290399003698 PAS domain S-box; Region: sensory_box; TIGR00229 290399003699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399003700 putative active site [active] 290399003701 heme pocket [chemical binding]; other site 290399003702 PAS fold; Region: PAS_7; pfam12860 290399003703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290399003704 metal binding site [ion binding]; metal-binding site 290399003705 active site 290399003706 I-site; other site 290399003707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399003708 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290399003709 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399003710 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290399003711 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 290399003712 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399003713 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 290399003714 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 290399003715 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 290399003716 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 290399003717 Ferredoxin [Energy production and conversion]; Region: COG1146 290399003718 4Fe-4S binding domain; Region: Fer4; cl02805 290399003719 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 290399003720 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290399003721 NAD(P) binding site [chemical binding]; other site 290399003722 catalytic residues [active] 290399003723 short chain dehydrogenase; Provisional; Region: PRK08339 290399003724 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 290399003725 putative NAD(P) binding site [chemical binding]; other site 290399003726 putative active site [active] 290399003727 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 290399003728 inhibitor site; inhibition site 290399003729 active site 290399003730 dimer interface [polypeptide binding]; other site 290399003731 catalytic residue [active] 290399003732 enoyl-CoA hydratase; Provisional; Region: PRK06494 290399003733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399003734 substrate binding site [chemical binding]; other site 290399003735 oxyanion hole (OAH) forming residues; other site 290399003736 trimer interface [polypeptide binding]; other site 290399003737 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290399003738 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290399003739 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 290399003740 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399003741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003742 putative substrate translocation pore; other site 290399003743 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290399003744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399003745 non-specific DNA binding site [nucleotide binding]; other site 290399003746 salt bridge; other site 290399003747 sequence-specific DNA binding site [nucleotide binding]; other site 290399003748 Cupin domain; Region: Cupin_2; pfam07883 290399003749 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 290399003750 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 290399003751 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 290399003752 active site 290399003753 substrate binding site [chemical binding]; other site 290399003754 cosubstrate binding site; other site 290399003755 catalytic site [active] 290399003756 benzoate transport; Region: 2A0115; TIGR00895 290399003757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003758 putative substrate translocation pore; other site 290399003759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399003760 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 290399003761 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 290399003762 purine monophosphate binding site [chemical binding]; other site 290399003763 dimer interface [polypeptide binding]; other site 290399003764 putative catalytic residues [active] 290399003765 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 290399003766 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 290399003767 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 290399003768 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 290399003769 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290399003770 putative hydrophobic ligand binding site [chemical binding]; other site 290399003771 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 290399003772 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 290399003773 heme binding pocket [chemical binding]; other site 290399003774 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 290399003775 domain interactions; other site 290399003776 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399003777 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399003778 active site 290399003779 ATP binding site [chemical binding]; other site 290399003780 substrate binding site [chemical binding]; other site 290399003781 activation loop (A-loop); other site 290399003782 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399003783 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399003784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290399003785 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290399003786 Walker A/P-loop; other site 290399003787 ATP binding site [chemical binding]; other site 290399003788 Q-loop/lid; other site 290399003789 ABC transporter signature motif; other site 290399003790 Walker B; other site 290399003791 D-loop; other site 290399003792 H-loop/switch region; other site 290399003793 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290399003794 FtsX-like permease family; Region: FtsX; pfam02687 290399003795 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 290399003796 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 290399003797 putative ligand binding site [chemical binding]; other site 290399003798 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399003799 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399003800 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399003801 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399003802 TM-ABC transporter signature motif; other site 290399003803 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290399003804 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290399003805 Walker A/P-loop; other site 290399003806 ATP binding site [chemical binding]; other site 290399003807 Q-loop/lid; other site 290399003808 ABC transporter signature motif; other site 290399003809 Walker B; other site 290399003810 D-loop; other site 290399003811 H-loop/switch region; other site 290399003812 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290399003813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399003814 dimerization interface [polypeptide binding]; other site 290399003815 putative DNA binding site [nucleotide binding]; other site 290399003816 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399003817 putative Zn2+ binding site [ion binding]; other site 290399003818 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399003819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290399003820 nucleotide binding site [chemical binding]; other site 290399003821 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290399003822 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 290399003823 active site 290399003824 catalytic triad [active] 290399003825 dimer interface [polypeptide binding]; other site 290399003826 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290399003827 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399003828 alanine racemase; Reviewed; Region: alr; PRK00053 290399003829 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290399003830 active site 290399003831 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290399003832 dimer interface [polypeptide binding]; other site 290399003833 substrate binding site [chemical binding]; other site 290399003834 catalytic residues [active] 290399003835 amino acid transporter; Region: 2A0306; TIGR00909 290399003836 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 290399003837 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290399003838 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399003839 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290399003840 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 290399003841 trimer interface [polypeptide binding]; other site 290399003842 putative metal binding site [ion binding]; other site 290399003843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399003844 S-adenosylmethionine binding site [chemical binding]; other site 290399003845 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290399003846 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290399003847 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290399003848 putative active site [active] 290399003849 putative substrate binding site [chemical binding]; other site 290399003850 putative cosubstrate binding site; other site 290399003851 catalytic site [active] 290399003852 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290399003853 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290399003854 dimer interface [polypeptide binding]; other site 290399003855 active site 290399003856 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290399003857 folate binding site [chemical binding]; other site 290399003858 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 290399003859 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290399003860 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290399003861 homodimer interface [polypeptide binding]; other site 290399003862 NADP binding site [chemical binding]; other site 290399003863 substrate binding site [chemical binding]; other site 290399003864 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290399003865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399003866 Walker A/P-loop; other site 290399003867 ATP binding site [chemical binding]; other site 290399003868 Q-loop/lid; other site 290399003869 ABC transporter signature motif; other site 290399003870 Walker B; other site 290399003871 D-loop; other site 290399003872 H-loop/switch region; other site 290399003873 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290399003874 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290399003875 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290399003876 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290399003877 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 290399003878 putative active site [active] 290399003879 putative catalytic site [active] 290399003880 putative DNA binding site [nucleotide binding]; other site 290399003881 putative phosphate binding site [ion binding]; other site 290399003882 metal binding site A [ion binding]; metal-binding site 290399003883 putative AP binding site [nucleotide binding]; other site 290399003884 putative metal binding site B [ion binding]; other site 290399003885 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290399003886 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290399003887 active site 290399003888 HIGH motif; other site 290399003889 dimer interface [polypeptide binding]; other site 290399003890 KMSKS motif; other site 290399003891 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 290399003892 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 290399003893 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 290399003894 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290399003895 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399003896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399003897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399003898 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 290399003899 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290399003900 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 290399003901 L-aspartate oxidase; Provisional; Region: PRK06175 290399003902 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290399003903 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 290399003904 putative Iron-sulfur protein interface [polypeptide binding]; other site 290399003905 putative proximal heme binding site [chemical binding]; other site 290399003906 putative SdhC-like subunit interface [polypeptide binding]; other site 290399003907 putative distal heme binding site [chemical binding]; other site 290399003908 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 290399003909 putative Iron-sulfur protein interface [polypeptide binding]; other site 290399003910 putative proximal heme binding site [chemical binding]; other site 290399003911 putative SdhD-like interface [polypeptide binding]; other site 290399003912 putative distal heme binding site [chemical binding]; other site 290399003913 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 290399003914 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399003915 active site 290399003916 Cupin domain; Region: Cupin_2; cl17218 290399003917 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290399003918 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 290399003919 metal binding site [ion binding]; metal-binding site 290399003920 putative dimer interface [polypeptide binding]; other site 290399003921 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290399003922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399003923 putative Zn2+ binding site [ion binding]; other site 290399003924 putative DNA binding site [nucleotide binding]; other site 290399003925 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 290399003926 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 290399003927 Prostaglandin dehydrogenases; Region: PGDH; cd05288 290399003928 NAD(P) binding site [chemical binding]; other site 290399003929 substrate binding site [chemical binding]; other site 290399003930 dimer interface [polypeptide binding]; other site 290399003931 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 290399003932 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 290399003933 ligand binding site [chemical binding]; other site 290399003934 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 290399003935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399003936 Walker A/P-loop; other site 290399003937 ATP binding site [chemical binding]; other site 290399003938 Q-loop/lid; other site 290399003939 ABC transporter signature motif; other site 290399003940 Walker B; other site 290399003941 D-loop; other site 290399003942 H-loop/switch region; other site 290399003943 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290399003944 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290399003945 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399003946 TM-ABC transporter signature motif; other site 290399003947 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399003948 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 290399003949 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290399003950 TM-ABC transporter signature motif; other site 290399003951 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 290399003952 active site 290399003953 catalytic motif [active] 290399003954 Zn binding site [ion binding]; other site 290399003955 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 290399003956 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290399003957 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290399003958 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 290399003959 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290399003960 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290399003961 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290399003962 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 290399003963 adenosine deaminase; Provisional; Region: PRK09358 290399003964 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 290399003965 active site 290399003966 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 290399003967 homodimer interface [polypeptide binding]; other site 290399003968 MazG family protein; Region: mazG; TIGR00444 290399003969 metal binding site [ion binding]; metal-binding site 290399003970 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 290399003971 enolase; Provisional; Region: eno; PRK00077 290399003972 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290399003973 dimer interface [polypeptide binding]; other site 290399003974 metal binding site [ion binding]; metal-binding site 290399003975 substrate binding pocket [chemical binding]; other site 290399003976 Septum formation initiator; Region: DivIC; pfam04977 290399003977 Protein of unknown function (DUF501); Region: DUF501; pfam04417 290399003978 exopolyphosphatase; Region: exo_poly_only; TIGR03706 290399003979 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290399003980 nucleotide binding site [chemical binding]; other site 290399003981 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 290399003982 active site 290399003983 catalytic residues [active] 290399003984 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290399003985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399003986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 290399003987 ACT domain; Region: ACT_3; pfam10000 290399003988 Family description; Region: ACT_7; pfam13840 290399003989 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290399003990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399003991 Coenzyme A binding pocket [chemical binding]; other site 290399003992 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290399003993 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290399003994 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 290399003995 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 290399003996 Walker A/P-loop; other site 290399003997 ATP binding site [chemical binding]; other site 290399003998 Q-loop/lid; other site 290399003999 ABC transporter signature motif; other site 290399004000 Walker B; other site 290399004001 D-loop; other site 290399004002 H-loop/switch region; other site 290399004003 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 290399004004 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 290399004005 Walker A/P-loop; other site 290399004006 ATP binding site [chemical binding]; other site 290399004007 Q-loop/lid; other site 290399004008 ABC transporter signature motif; other site 290399004009 Walker B; other site 290399004010 D-loop; other site 290399004011 H-loop/switch region; other site 290399004012 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 290399004013 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 290399004014 TM-ABC transporter signature motif; other site 290399004015 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399004016 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 290399004017 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399004018 TM-ABC transporter signature motif; other site 290399004019 Bax inhibitor 1 like; Region: BaxI_1; cl17691 290399004020 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 290399004021 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 290399004022 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290399004023 dimer interface [polypeptide binding]; other site 290399004024 active site 290399004025 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 290399004026 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 290399004027 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 290399004028 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 290399004029 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 290399004030 dimer interface [polypeptide binding]; other site 290399004031 active site 290399004032 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290399004033 active site 290399004034 catalytic residues [active] 290399004035 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290399004036 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290399004037 threonine dehydratase; Provisional; Region: PRK08198 290399004038 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 290399004039 tetramer interface [polypeptide binding]; other site 290399004040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399004041 catalytic residue [active] 290399004042 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 290399004043 Rhomboid family; Region: Rhomboid; cl11446 290399004044 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 290399004045 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290399004046 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290399004047 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 290399004048 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 290399004049 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 290399004050 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 290399004051 catalytic residues [active] 290399004052 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 290399004053 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 290399004054 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 290399004055 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290399004056 catalytic residue [active] 290399004057 putative FPP diphosphate binding site; other site 290399004058 putative FPP binding hydrophobic cleft; other site 290399004059 dimer interface [polypeptide binding]; other site 290399004060 putative IPP diphosphate binding site; other site 290399004061 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 290399004062 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 290399004063 putative active site [active] 290399004064 PhoH-like protein; Region: PhoH; pfam02562 290399004065 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290399004066 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 290399004067 nudix motif; other site 290399004068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399004069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399004070 putative substrate translocation pore; other site 290399004071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399004072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399004073 fumarate hydratase; Reviewed; Region: fumC; PRK00485 290399004074 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 290399004075 active sites [active] 290399004076 tetramer interface [polypeptide binding]; other site 290399004077 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 290399004078 active site clefts [active] 290399004079 zinc binding site [ion binding]; other site 290399004080 dimer interface [polypeptide binding]; other site 290399004081 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 290399004082 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 290399004083 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 290399004084 putative active site [active] 290399004085 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 290399004086 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 290399004087 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290399004088 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 290399004089 Transcriptional regulator [Transcription]; Region: LytR; COG1316 290399004090 AIR carboxylase; Region: AIRC; pfam00731 290399004091 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 290399004092 LabA_like proteins; Region: LabA_like/DUF88; cl10034 290399004093 ATP-grasp domain; Region: ATP-grasp; pfam02222 290399004094 Predicted membrane protein [Function unknown]; Region: COG2246 290399004095 GtrA-like protein; Region: GtrA; pfam04138 290399004096 TIGR03089 family protein; Region: TIGR03089 290399004097 Transcription factor WhiB; Region: Whib; pfam02467 290399004098 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290399004099 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399004100 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399004101 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 290399004102 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 290399004103 Trm112p-like protein; Region: Trm112p; cl01066 290399004104 Adenosylhomocysteinase; Provisional; Region: PTZ00075 290399004105 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 290399004106 homotetramer interface [polypeptide binding]; other site 290399004107 ligand binding site [chemical binding]; other site 290399004108 catalytic site [active] 290399004109 NAD binding site [chemical binding]; other site 290399004110 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 290399004111 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 290399004112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 290399004113 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290399004114 Bacterial Ig-like domain; Region: Big_5; pfam13205 290399004115 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 290399004116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 290399004117 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290399004118 RDD family; Region: RDD; pfam06271 290399004119 Integral membrane protein DUF95; Region: DUF95; pfam01944 290399004120 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 290399004121 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290399004122 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 290399004123 acyl-activating enzyme (AAE) consensus motif; other site 290399004124 putative AMP binding site [chemical binding]; other site 290399004125 putative active site [active] 290399004126 putative CoA binding site [chemical binding]; other site 290399004127 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 290399004128 Predicted methyltransferases [General function prediction only]; Region: COG0313 290399004129 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 290399004130 putative SAM binding site [chemical binding]; other site 290399004131 putative homodimer interface [polypeptide binding]; other site 290399004132 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399004133 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290399004134 tetramerization interface [polypeptide binding]; other site 290399004135 NAD(P) binding site [chemical binding]; other site 290399004136 catalytic residues [active] 290399004137 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290399004138 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290399004139 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290399004140 Protein of unknown function DUF58; Region: DUF58; pfam01882 290399004141 MoxR-like ATPases [General function prediction only]; Region: COG0714 290399004142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399004143 Walker A motif; other site 290399004144 ATP binding site [chemical binding]; other site 290399004145 Walker B motif; other site 290399004146 arginine finger; other site 290399004147 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290399004148 active site 290399004149 Domain of unknown function (DUF348); Region: DUF348; pfam03990 290399004150 Domain of unknown function (DUF348); Region: DUF348; pfam03990 290399004151 Domain of unknown function (DUF348); Region: DUF348; pfam03990 290399004152 G5 domain; Region: G5; pfam07501 290399004153 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 290399004154 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 290399004155 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 290399004156 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 290399004157 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290399004158 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290399004159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399004160 ABC transporter; Region: ABC_tran_2; pfam12848 290399004161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399004162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399004163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399004164 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 290399004165 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 290399004166 Substrate binding site; other site 290399004167 Mg++ binding site; other site 290399004168 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 290399004169 active site 290399004170 substrate binding site [chemical binding]; other site 290399004171 CoA binding site [chemical binding]; other site 290399004172 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 290399004173 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 290399004174 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399004175 active site 290399004176 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 290399004177 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 290399004178 5S rRNA interface [nucleotide binding]; other site 290399004179 CTC domain interface [polypeptide binding]; other site 290399004180 L16 interface [polypeptide binding]; other site 290399004181 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 290399004182 putative active site [active] 290399004183 catalytic residue [active] 290399004184 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399004185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399004186 DNA binding residues [nucleotide binding] 290399004187 dimerization interface [polypeptide binding]; other site 290399004188 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399004189 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399004190 DNA binding residues [nucleotide binding] 290399004191 AAA domain; Region: AAA_14; pfam13173 290399004192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399004193 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 290399004194 DNA binding residues [nucleotide binding] 290399004195 dimerization interface [polypeptide binding]; other site 290399004196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399004197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399004198 DNA binding residues [nucleotide binding] 290399004199 dimerization interface [polypeptide binding]; other site 290399004200 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 290399004201 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290399004202 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 290399004203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399004204 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399004205 NAD(P) binding site [chemical binding]; other site 290399004206 active site 290399004207 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 290399004208 S-layer homology domain; Region: SLH; pfam00395 290399004209 S-layer homology domain; Region: SLH; pfam00395 290399004210 S-layer homology domain; Region: SLH; pfam00395 290399004211 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 290399004212 active site 290399004213 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 290399004214 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290399004215 putative active site [active] 290399004216 putative metal binding site [ion binding]; other site 290399004217 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 290399004218 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290399004219 putative active site [active] 290399004220 putative metal binding site [ion binding]; other site 290399004221 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290399004222 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290399004223 DXD motif; other site 290399004224 AAA ATPase domain; Region: AAA_16; pfam13191 290399004225 AAA domain; Region: AAA_22; pfam13401 290399004226 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399004227 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399004228 DNA binding residues [nucleotide binding] 290399004229 dimerization interface [polypeptide binding]; other site 290399004230 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290399004231 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 290399004232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399004233 catalytic residue [active] 290399004234 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 290399004235 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 290399004236 trimerization site [polypeptide binding]; other site 290399004237 active site 290399004238 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399004239 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 290399004240 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 290399004241 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 290399004242 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 290399004243 active site 290399004244 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 290399004245 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290399004246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399004247 NAD(P) binding site [chemical binding]; other site 290399004248 active site 290399004249 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 290399004250 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 290399004251 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821 290399004252 putative heme binding site [chemical binding]; other site 290399004253 putative substrate binding site [chemical binding]; other site 290399004254 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 290399004255 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290399004256 Interdomain contacts; other site 290399004257 Cytokine receptor motif; other site 290399004258 S-layer homology domain; Region: SLH; pfam00395 290399004259 S-layer homology domain; Region: SLH; pfam00395 290399004260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 290399004261 DNA binding site [nucleotide binding] 290399004262 Bacterial transcriptional activator domain; Region: BTAD; smart01043 290399004263 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 290399004264 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 290399004265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399004266 ATP binding site [chemical binding]; other site 290399004267 putative Mg++ binding site [ion binding]; other site 290399004268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399004269 nucleotide binding region [chemical binding]; other site 290399004270 ATP-binding site [chemical binding]; other site 290399004271 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 290399004272 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 290399004273 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 290399004274 intersubunit interface [polypeptide binding]; other site 290399004275 active site 290399004276 catalytic residue [active] 290399004277 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 290399004278 Patatin-like phospholipase; Region: Patatin; pfam01734 290399004279 active site 290399004280 nucleophile elbow; other site 290399004281 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 290399004282 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 290399004283 triacylglycerol lipase; Region: PLN02872 290399004284 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 290399004285 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290399004286 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 290399004287 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290399004288 active site 290399004289 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 290399004290 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290399004291 homodimer interface [polypeptide binding]; other site 290399004292 active site 290399004293 SAM binding site [chemical binding]; other site 290399004294 nitrite reductase subunit NirD; Provisional; Region: PRK14989 290399004295 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290399004296 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290399004297 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290399004298 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 290399004299 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 290399004300 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 290399004301 active site 290399004302 substrate binding site [chemical binding]; other site 290399004303 metal binding site [ion binding]; metal-binding site 290399004304 Predicted transcriptional regulator [Transcription]; Region: COG1959 290399004305 Transcriptional regulator; Region: Rrf2; pfam02082 290399004306 purine nucleoside phosphorylase; Provisional; Region: PRK08202 290399004307 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 290399004308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399004309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399004310 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399004311 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 290399004312 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 290399004313 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 290399004314 [4Fe-4S] binding site [ion binding]; other site 290399004315 molybdopterin cofactor binding site; other site 290399004316 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 290399004317 molybdopterin cofactor binding site; other site 290399004318 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 290399004319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399004320 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399004321 putative substrate translocation pore; other site 290399004322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399004323 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290399004324 catalytic triad [active] 290399004325 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290399004326 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290399004327 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290399004328 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290399004329 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290399004330 carboxyltransferase (CT) interaction site; other site 290399004331 biotinylation site [posttranslational modification]; other site 290399004332 Maf-like protein; Region: Maf; pfam02545 290399004333 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290399004334 active site 290399004335 dimer interface [polypeptide binding]; other site 290399004336 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399004337 active site 290399004338 MMPL family; Region: MMPL; pfam03176 290399004339 MMPL family; Region: MMPL; pfam03176 290399004340 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 290399004341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399004342 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 290399004343 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 290399004344 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290399004345 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 290399004346 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 290399004347 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 290399004348 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290399004349 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290399004350 short chain dehydrogenase; Provisional; Region: PRK08278 290399004351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399004352 NAD(P) binding site [chemical binding]; other site 290399004353 active site 290399004354 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 290399004355 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 290399004356 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 290399004357 Bacterial PH domain; Region: DUF304; pfam03703 290399004358 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 290399004359 cyclase homology domain; Region: CHD; cd07302 290399004360 nucleotidyl binding site; other site 290399004361 metal binding site [ion binding]; metal-binding site 290399004362 dimer interface [polypeptide binding]; other site 290399004363 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290399004364 Interdomain contacts; other site 290399004365 Cytokine receptor motif; other site 290399004366 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290399004367 Interdomain contacts; other site 290399004368 Cytokine receptor motif; other site 290399004369 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290399004370 Interdomain contacts; other site 290399004371 Cytokine receptor motif; other site 290399004372 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290399004373 Interdomain contacts; other site 290399004374 Cytokine receptor motif; other site 290399004375 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290399004376 Interdomain contacts; other site 290399004377 Cytokine receptor motif; other site 290399004378 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 290399004379 MoxR-like ATPases [General function prediction only]; Region: COG0714 290399004380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399004381 Walker A motif; other site 290399004382 ATP binding site [chemical binding]; other site 290399004383 Walker B motif; other site 290399004384 arginine finger; other site 290399004385 Protein of unknown function DUF58; Region: DUF58; pfam01882 290399004386 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290399004387 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290399004388 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 290399004389 Double zinc ribbon; Region: DZR; pfam12773 290399004390 RDD family; Region: RDD; pfam06271 290399004391 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 290399004392 phosphopeptide binding site; other site 290399004393 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 290399004394 Protein phosphatase 2C; Region: PP2C; pfam00481 290399004395 active site 290399004396 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 290399004397 phosphopeptide binding site; other site 290399004398 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399004399 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399004400 active site 290399004401 ATP binding site [chemical binding]; other site 290399004402 substrate binding site [chemical binding]; other site 290399004403 activation loop (A-loop); other site 290399004404 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290399004405 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290399004406 phosphopeptide binding site; other site 290399004407 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 290399004408 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290399004409 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290399004410 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 290399004411 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 290399004412 nucleotide binding pocket [chemical binding]; other site 290399004413 K-X-D-G motif; other site 290399004414 catalytic site [active] 290399004415 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290399004416 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 290399004417 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 290399004418 Dimer interface [polypeptide binding]; other site 290399004419 BRCT sequence motif; other site 290399004420 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290399004421 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 290399004422 active site 290399004423 dimerization interface [polypeptide binding]; other site 290399004424 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290399004425 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290399004426 active site 290399004427 non-prolyl cis peptide bond; other site 290399004428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290399004429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399004430 Coenzyme A binding pocket [chemical binding]; other site 290399004431 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 290399004432 homotrimer interaction site [polypeptide binding]; other site 290399004433 putative active site [active] 290399004434 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290399004435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399004436 active site 290399004437 dimerization interface [polypeptide binding]; other site 290399004438 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 290399004439 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290399004440 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399004441 putative active site [active] 290399004442 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 290399004443 Citrate transporter; Region: CitMHS; pfam03600 290399004444 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 290399004445 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 290399004446 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290399004447 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 290399004448 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 290399004449 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 290399004450 GatB domain; Region: GatB_Yqey; smart00845 290399004451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399004452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399004453 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290399004454 putative dimerization interface [polypeptide binding]; other site 290399004455 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 290399004456 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290399004457 NAD(P) binding site [chemical binding]; other site 290399004458 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 290399004459 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 290399004460 substrate-cofactor binding pocket; other site 290399004461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399004462 catalytic residue [active] 290399004463 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290399004464 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290399004465 imidazolonepropionase; Provisional; Region: PRK14085 290399004466 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 290399004467 active site 290399004468 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399004469 catalytic core [active] 290399004470 CAAX protease self-immunity; Region: Abi; pfam02517 290399004471 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 290399004472 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 290399004473 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290399004474 homodimer interface [polypeptide binding]; other site 290399004475 substrate-cofactor binding pocket; other site 290399004476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399004477 catalytic residue [active] 290399004478 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 290399004479 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 290399004480 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399004481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399004482 putative substrate translocation pore; other site 290399004483 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 290399004484 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 290399004485 NAD binding site [chemical binding]; other site 290399004486 catalytic Zn binding site [ion binding]; other site 290399004487 substrate binding site [chemical binding]; other site 290399004488 structural Zn binding site [ion binding]; other site 290399004489 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399004490 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399004491 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290399004492 dimerization interface [polypeptide binding]; other site 290399004493 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 290399004494 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399004495 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 290399004496 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 290399004497 tetrameric interface [polypeptide binding]; other site 290399004498 NAD binding site [chemical binding]; other site 290399004499 catalytic residues [active] 290399004500 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290399004501 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290399004502 active site 290399004503 catalytic triad [active] 290399004504 oxyanion hole [active] 290399004505 putative hydrolase; Provisional; Region: PRK11460 290399004506 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 290399004507 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290399004508 RNA binding surface [nucleotide binding]; other site 290399004509 Protein of unknown function, DUF606; Region: DUF606; pfam04657 290399004510 Protein of unknown function, DUF606; Region: DUF606; pfam04657 290399004511 glycyl-tRNA synthetase; Provisional; Region: PRK04173 290399004512 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290399004513 motif 1; other site 290399004514 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 290399004515 active site 290399004516 motif 2; other site 290399004517 motif 3; other site 290399004518 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 290399004519 anticodon binding site; other site 290399004520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290399004521 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290399004522 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290399004523 putative acyl-acceptor binding pocket; other site 290399004524 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 290399004525 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 290399004526 YibE/F-like protein; Region: YibE_F; pfam07907 290399004527 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 290399004528 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290399004529 FMN binding site [chemical binding]; other site 290399004530 active site 290399004531 catalytic residues [active] 290399004532 substrate binding site [chemical binding]; other site 290399004533 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 290399004534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290399004535 Zn2+ binding site [ion binding]; other site 290399004536 Mg2+ binding site [ion binding]; other site 290399004537 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 290399004538 DNA primase; Validated; Region: dnaG; PRK05667 290399004539 CHC2 zinc finger; Region: zf-CHC2; pfam01807 290399004540 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290399004541 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290399004542 active site 290399004543 metal binding site [ion binding]; metal-binding site 290399004544 interdomain interaction site; other site 290399004545 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 290399004546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399004547 putative substrate translocation pore; other site 290399004548 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 290399004549 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 290399004550 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 290399004551 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 290399004552 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399004553 putative ADP-binding pocket [chemical binding]; other site 290399004554 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290399004555 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290399004556 active site 290399004557 DNA binding site [nucleotide binding] 290399004558 Int/Topo IB signature motif; other site 290399004559 Helix-turn-helix domain; Region: HTH_36; pfam13730 290399004560 Helix-turn-helix domain; Region: HTH_17; cl17695 290399004561 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 290399004562 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399004563 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 290399004564 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 290399004565 acyl-coenzyme A oxidase; Region: PLN02526 290399004566 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399004567 active site 290399004568 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290399004569 Peptidase family M23; Region: Peptidase_M23; pfam01551 290399004570 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 290399004571 rRNA interaction site [nucleotide binding]; other site 290399004572 S8 interaction site; other site 290399004573 putative laminin-1 binding site; other site 290399004574 elongation factor Ts; Provisional; Region: tsf; PRK09377 290399004575 UBA/TS-N domain; Region: UBA; pfam00627 290399004576 Elongation factor TS; Region: EF_TS; pfam00889 290399004577 Elongation factor TS; Region: EF_TS; pfam00889 290399004578 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 290399004579 putative nucleotide binding site [chemical binding]; other site 290399004580 uridine monophosphate binding site [chemical binding]; other site 290399004581 homohexameric interface [polypeptide binding]; other site 290399004582 ribosome recycling factor; Reviewed; Region: frr; PRK00083 290399004583 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 290399004584 hinge region; other site 290399004585 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 290399004586 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 290399004587 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 290399004588 DivIVA domain; Region: DivI1A_domain; TIGR03544 290399004589 DivIVA domain; Region: DivI1A_domain; TIGR03544 290399004590 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290399004591 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 290399004592 Na binding site [ion binding]; other site 290399004593 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 290399004594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399004595 active site 290399004596 phosphorylation site [posttranslational modification] 290399004597 intermolecular recognition site; other site 290399004598 dimerization interface [polypeptide binding]; other site 290399004599 LytTr DNA-binding domain; Region: LytTR; smart00850 290399004600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290399004601 Histidine kinase; Region: His_kinase; pfam06580 290399004602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399004603 ATP binding site [chemical binding]; other site 290399004604 Mg2+ binding site [ion binding]; other site 290399004605 G-X-G motif; other site 290399004606 Protein of unknown function, DUF485; Region: DUF485; pfam04341 290399004607 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290399004608 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 290399004609 Na binding site [ion binding]; other site 290399004610 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399004611 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290399004612 putative DNA binding site [nucleotide binding]; other site 290399004613 putative Zn2+ binding site [ion binding]; other site 290399004614 AsnC family; Region: AsnC_trans_reg; pfam01037 290399004615 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290399004616 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290399004617 TPP-binding site [chemical binding]; other site 290399004618 tetramer interface [polypeptide binding]; other site 290399004619 heterodimer interface [polypeptide binding]; other site 290399004620 phosphorylation loop region [posttranslational modification] 290399004621 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290399004622 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290399004623 alpha subunit interface [polypeptide binding]; other site 290399004624 TPP binding site [chemical binding]; other site 290399004625 heterodimer interface [polypeptide binding]; other site 290399004626 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399004627 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290399004628 E3 interaction surface; other site 290399004629 lipoyl attachment site [posttranslational modification]; other site 290399004630 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 290399004631 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290399004632 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399004633 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399004634 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 290399004635 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290399004636 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290399004637 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 290399004638 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290399004639 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290399004640 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 290399004641 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290399004642 carboxyltransferase (CT) interaction site; other site 290399004643 biotinylation site [posttranslational modification]; other site 290399004644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290399004645 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399004646 active site 290399004647 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 290399004648 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 290399004649 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 290399004650 putative active site [active] 290399004651 putative catalytic site [active] 290399004652 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 290399004653 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399004654 Ligand Binding Site [chemical binding]; other site 290399004655 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 290399004656 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 290399004657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 290399004658 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290399004659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399004660 putative active site [active] 290399004661 heme pocket [chemical binding]; other site 290399004662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399004663 ATP binding site [chemical binding]; other site 290399004664 Mg2+ binding site [ion binding]; other site 290399004665 G-X-G motif; other site 290399004666 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290399004667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399004668 active site 290399004669 phosphorylation site [posttranslational modification] 290399004670 intermolecular recognition site; other site 290399004671 dimerization interface [polypeptide binding]; other site 290399004672 Lipase maturation factor; Region: LMF1; pfam06762 290399004673 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 290399004674 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 290399004675 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 290399004676 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 290399004677 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 290399004678 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290399004679 active site 290399004680 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290399004681 protein binding site [polypeptide binding]; other site 290399004682 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290399004683 YCII-related domain; Region: YCII; cl00999 290399004684 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290399004685 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 290399004686 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290399004687 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 290399004688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290399004689 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290399004690 prolyl-tRNA synthetase; Provisional; Region: PRK09194 290399004691 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 290399004692 dimer interface [polypeptide binding]; other site 290399004693 motif 1; other site 290399004694 active site 290399004695 motif 2; other site 290399004696 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 290399004697 putative deacylase active site [active] 290399004698 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290399004699 active site 290399004700 motif 3; other site 290399004701 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 290399004702 anticodon binding site; other site 290399004703 hypothetical protein; Provisional; Region: PRK10621 290399004704 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290399004705 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 290399004706 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399004707 catalytic residue [active] 290399004708 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 290399004709 CCC1-related family of proteins; Region: CCC1_like; cl00278 290399004710 ribosome maturation protein RimP; Reviewed; Region: PRK00092 290399004711 Sm and related proteins; Region: Sm_like; cl00259 290399004712 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 290399004713 putative oligomer interface [polypeptide binding]; other site 290399004714 putative RNA binding site [nucleotide binding]; other site 290399004715 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 290399004716 NusA N-terminal domain; Region: NusA_N; pfam08529 290399004717 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 290399004718 RNA binding site [nucleotide binding]; other site 290399004719 homodimer interface [polypeptide binding]; other site 290399004720 NusA-like KH domain; Region: KH_5; pfam13184 290399004721 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 290399004722 G-X-X-G motif; other site 290399004723 Protein of unknown function (DUF448); Region: DUF448; pfam04296 290399004724 putative RNA binding cleft [nucleotide binding]; other site 290399004725 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290399004726 translation initiation factor IF-2; Region: IF-2; TIGR00487 290399004727 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290399004728 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 290399004729 G1 box; other site 290399004730 putative GEF interaction site [polypeptide binding]; other site 290399004731 GTP/Mg2+ binding site [chemical binding]; other site 290399004732 Switch I region; other site 290399004733 G2 box; other site 290399004734 G3 box; other site 290399004735 Switch II region; other site 290399004736 G4 box; other site 290399004737 G5 box; other site 290399004738 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 290399004739 Translation-initiation factor 2; Region: IF-2; pfam11987 290399004740 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 290399004741 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 290399004742 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 290399004743 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290399004744 nucleoside/Zn binding site; other site 290399004745 dimer interface [polypeptide binding]; other site 290399004746 catalytic motif [active] 290399004747 thioredoxin 2; Provisional; Region: PRK10996 290399004748 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290399004749 catalytic residues [active] 290399004750 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290399004751 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399004752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399004753 homodimer interface [polypeptide binding]; other site 290399004754 catalytic residue [active] 290399004755 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 290399004756 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 290399004757 RNA binding site [nucleotide binding]; other site 290399004758 active site 290399004759 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290399004760 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399004761 active site 290399004762 topology modulation protein; Reviewed; Region: PRK08118 290399004763 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 290399004764 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 290399004765 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 290399004766 active site 290399004767 Riboflavin kinase; Region: Flavokinase; smart00904 290399004768 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 290399004769 kynureninase; Region: kynureninase; TIGR01814 290399004770 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290399004771 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399004772 catalytic residue [active] 290399004773 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 290399004774 16S/18S rRNA binding site [nucleotide binding]; other site 290399004775 S13e-L30e interaction site [polypeptide binding]; other site 290399004776 25S rRNA binding site [nucleotide binding]; other site 290399004777 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 290399004778 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 290399004779 oligomer interface [polypeptide binding]; other site 290399004780 RNA binding site [nucleotide binding]; other site 290399004781 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 290399004782 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 290399004783 RNase E interface [polypeptide binding]; other site 290399004784 trimer interface [polypeptide binding]; other site 290399004785 active site 290399004786 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 290399004787 putative nucleic acid binding region [nucleotide binding]; other site 290399004788 G-X-X-G motif; other site 290399004789 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290399004790 RNA binding site [nucleotide binding]; other site 290399004791 domain interface; other site 290399004792 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290399004793 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290399004794 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290399004795 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 290399004796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399004797 FeS/SAM binding site; other site 290399004798 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290399004799 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399004800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399004801 active site 290399004802 phosphorylation site [posttranslational modification] 290399004803 intermolecular recognition site; other site 290399004804 dimerization interface [polypeptide binding]; other site 290399004805 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399004806 DNA binding site [nucleotide binding] 290399004807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399004808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399004809 dimer interface [polypeptide binding]; other site 290399004810 phosphorylation site [posttranslational modification] 290399004811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399004812 ATP binding site [chemical binding]; other site 290399004813 Mg2+ binding site [ion binding]; other site 290399004814 G-X-G motif; other site 290399004815 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290399004816 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 290399004817 Moco binding site; other site 290399004818 metal coordination site [ion binding]; other site 290399004819 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290399004820 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290399004821 dimer interface [polypeptide binding]; other site 290399004822 putative functional site; other site 290399004823 putative MPT binding site; other site 290399004824 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 290399004825 trimer interface [polypeptide binding]; other site 290399004826 dimer interface [polypeptide binding]; other site 290399004827 putative active site [active] 290399004828 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 290399004829 MPT binding site; other site 290399004830 trimer interface [polypeptide binding]; other site 290399004831 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 290399004832 MoaE homodimer interface [polypeptide binding]; other site 290399004833 MoaD interaction [polypeptide binding]; other site 290399004834 active site residues [active] 290399004835 dihydrodipicolinate reductase; Provisional; Region: PRK00048 290399004836 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 290399004837 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 290399004838 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 290399004839 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290399004840 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 290399004841 dimer interface [polypeptide binding]; other site 290399004842 active site 290399004843 catalytic residue [active] 290399004844 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 290399004845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290399004846 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 290399004847 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 290399004848 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 290399004849 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290399004850 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 290399004851 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 290399004852 Competence-damaged protein; Region: CinA; pfam02464 290399004853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399004854 non-specific DNA binding site [nucleotide binding]; other site 290399004855 salt bridge; other site 290399004856 sequence-specific DNA binding site [nucleotide binding]; other site 290399004857 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399004858 MarR family; Region: MarR; pfam01047 290399004859 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 290399004860 recombinase A; Provisional; Region: recA; PRK09354 290399004861 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 290399004862 hexamer interface [polypeptide binding]; other site 290399004863 Walker A motif; other site 290399004864 ATP binding site [chemical binding]; other site 290399004865 Walker B motif; other site 290399004866 recombination regulator RecX; Reviewed; Region: recX; PRK00117 290399004867 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 290399004868 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290399004869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399004870 FeS/SAM binding site; other site 290399004871 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 290399004872 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 290399004873 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 290399004874 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290399004875 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290399004876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399004877 S-adenosylmethionine binding site [chemical binding]; other site 290399004878 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 290399004879 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 290399004880 HflX GTPase family; Region: HflX; cd01878 290399004881 G1 box; other site 290399004882 GTP/Mg2+ binding site [chemical binding]; other site 290399004883 Switch I region; other site 290399004884 G2 box; other site 290399004885 G3 box; other site 290399004886 Switch II region; other site 290399004887 G4 box; other site 290399004888 G5 box; other site 290399004889 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 290399004890 DEAD/DEAH box helicase; Region: DEAD; pfam00270 290399004891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290399004892 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 290399004893 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 290399004894 LexA repressor; Validated; Region: PRK00215 290399004895 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290399004896 Catalytic site [active] 290399004897 LysM domain; Region: LysM; pfam01476 290399004898 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 290399004899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399004900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399004901 homodimer interface [polypeptide binding]; other site 290399004902 catalytic residue [active] 290399004903 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 290399004904 putative active site pocket [active] 290399004905 4-fold oligomerization interface [polypeptide binding]; other site 290399004906 metal binding residues [ion binding]; metal-binding site 290399004907 3-fold/trimer interface [polypeptide binding]; other site 290399004908 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 290399004909 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 290399004910 putative active site [active] 290399004911 oxyanion strand; other site 290399004912 catalytic triad [active] 290399004913 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 290399004914 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290399004915 catalytic residues [active] 290399004916 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399004917 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 290399004918 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 290399004919 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 290399004920 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 290399004921 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 290399004922 23S rRNA binding site [nucleotide binding]; other site 290399004923 L21 binding site [polypeptide binding]; other site 290399004924 L13 binding site [polypeptide binding]; other site 290399004925 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290399004926 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 290399004927 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290399004928 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 290399004929 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290399004930 Cation efflux family; Region: Cation_efflux; pfam01545 290399004931 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290399004932 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399004933 putative substrate translocation pore; other site 290399004934 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290399004935 active site 290399004936 8-oxo-dGMP binding site [chemical binding]; other site 290399004937 nudix motif; other site 290399004938 metal binding site [ion binding]; metal-binding site 290399004939 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290399004940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399004941 FeS/SAM binding site; other site 290399004942 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 290399004943 putative substrate binding pocket [chemical binding]; other site 290399004944 AC domain interface; other site 290399004945 catalytic triad [active] 290399004946 AB domain interface; other site 290399004947 interchain disulfide; other site 290399004948 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 290399004949 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 290399004950 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 290399004951 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 290399004952 dimer interface [polypeptide binding]; other site 290399004953 motif 1; other site 290399004954 active site 290399004955 motif 2; other site 290399004956 motif 3; other site 290399004957 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 290399004958 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 290399004959 putative tRNA-binding site [nucleotide binding]; other site 290399004960 B3/4 domain; Region: B3_4; pfam03483 290399004961 tRNA synthetase B5 domain; Region: B5; pfam03484 290399004962 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 290399004963 dimer interface [polypeptide binding]; other site 290399004964 motif 1; other site 290399004965 motif 3; other site 290399004966 motif 2; other site 290399004967 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 290399004968 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290399004969 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 290399004970 Zn binding site [ion binding]; other site 290399004971 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399004972 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 290399004973 acyl-activating enzyme (AAE) consensus motif; other site 290399004974 AMP binding site [chemical binding]; other site 290399004975 active site 290399004976 CoA binding site [chemical binding]; other site 290399004977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290399004978 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 290399004979 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290399004980 putative trimer interface [polypeptide binding]; other site 290399004981 putative CoA binding site [chemical binding]; other site 290399004982 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290399004983 putative trimer interface [polypeptide binding]; other site 290399004984 putative CoA binding site [chemical binding]; other site 290399004985 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 290399004986 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 290399004987 NADP binding site [chemical binding]; other site 290399004988 dimer interface [polypeptide binding]; other site 290399004989 Fatty acid desaturase; Region: FA_desaturase; pfam00487 290399004990 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 290399004991 putative di-iron ligands [ion binding]; other site 290399004992 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 290399004993 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290399004994 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 290399004995 heterotetramer interface [polypeptide binding]; other site 290399004996 active site pocket [active] 290399004997 cleavage site 290399004998 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 290399004999 feedback inhibition sensing region; other site 290399005000 homohexameric interface [polypeptide binding]; other site 290399005001 nucleotide binding site [chemical binding]; other site 290399005002 N-acetyl-L-glutamate binding site [chemical binding]; other site 290399005003 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 290399005004 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290399005005 inhibitor-cofactor binding pocket; inhibition site 290399005006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399005007 catalytic residue [active] 290399005008 ornithine carbamoyltransferase; Provisional; Region: PRK00779 290399005009 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290399005010 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290399005011 arginine repressor; Provisional; Region: PRK03341 290399005012 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290399005013 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290399005014 argininosuccinate synthase; Provisional; Region: PRK13820 290399005015 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 290399005016 ANP binding site [chemical binding]; other site 290399005017 Substrate Binding Site II [chemical binding]; other site 290399005018 Substrate Binding Site I [chemical binding]; other site 290399005019 argininosuccinate lyase; Provisional; Region: PRK00855 290399005020 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 290399005021 active sites [active] 290399005022 tetramer interface [polypeptide binding]; other site 290399005023 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290399005024 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 290399005025 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 290399005026 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 290399005027 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 290399005028 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 290399005029 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290399005030 DNA binding site [nucleotide binding] 290399005031 active site 290399005032 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 290399005033 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 290399005034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399005035 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 290399005036 AlkA N-terminal domain; Region: AlkA_N; pfam06029 290399005037 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290399005038 minor groove reading motif; other site 290399005039 helix-hairpin-helix signature motif; other site 290399005040 active site 290399005041 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 290399005042 active site 290399005043 DNA binding site [nucleotide binding] 290399005044 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399005045 active site 290399005046 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 290399005047 Winged helix-turn helix; Region: HTH_29; pfam13551 290399005048 Integrase core domain; Region: rve; pfam00665 290399005049 Integrase core domain; Region: rve_3; pfam13683 290399005050 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 290399005051 Part of AAA domain; Region: AAA_19; pfam13245 290399005052 Family description; Region: UvrD_C_2; pfam13538 290399005053 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 290399005054 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 290399005055 active site 290399005056 HIGH motif; other site 290399005057 dimer interface [polypeptide binding]; other site 290399005058 KMSKS motif; other site 290399005059 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290399005060 RNA binding surface [nucleotide binding]; other site 290399005061 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 290399005062 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 290399005063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399005064 active site 290399005065 motif I; other site 290399005066 motif II; other site 290399005067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399005068 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 290399005069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290399005070 RNA binding surface [nucleotide binding]; other site 290399005071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399005072 S-adenosylmethionine binding site [chemical binding]; other site 290399005073 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 290399005074 ATP-NAD kinase; Region: NAD_kinase; pfam01513 290399005075 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 290399005076 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290399005077 Walker A/P-loop; other site 290399005078 ATP binding site [chemical binding]; other site 290399005079 Q-loop/lid; other site 290399005080 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290399005081 ABC transporter signature motif; other site 290399005082 Walker B; other site 290399005083 D-loop; other site 290399005084 H-loop/switch region; other site 290399005085 CTP synthetase; Validated; Region: pyrG; PRK05380 290399005086 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 290399005087 Catalytic site [active] 290399005088 active site 290399005089 UTP binding site [chemical binding]; other site 290399005090 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 290399005091 active site 290399005092 putative oxyanion hole; other site 290399005093 catalytic triad [active] 290399005094 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290399005095 dimer interface [polypeptide binding]; other site 290399005096 ADP-ribose binding site [chemical binding]; other site 290399005097 active site 290399005098 nudix motif; other site 290399005099 metal binding site [ion binding]; metal-binding site 290399005100 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 290399005101 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290399005102 active site 290399005103 Int/Topo IB signature motif; other site 290399005104 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 290399005105 putative active site [active] 290399005106 nucleotide binding site [chemical binding]; other site 290399005107 nudix motif; other site 290399005108 putative metal binding site [ion binding]; other site 290399005109 citrate synthase; Provisional; Region: PRK14033 290399005110 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 290399005111 oxalacetate binding site [chemical binding]; other site 290399005112 citrylCoA binding site [chemical binding]; other site 290399005113 coenzyme A binding site [chemical binding]; other site 290399005114 catalytic triad [active] 290399005115 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290399005116 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290399005117 tetramer interface [polypeptide binding]; other site 290399005118 active site 290399005119 Mg2+/Mn2+ binding site [ion binding]; other site 290399005120 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 290399005121 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399005122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399005123 DNA-binding site [nucleotide binding]; DNA binding site 290399005124 FCD domain; Region: FCD; pfam07729 290399005125 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 290399005126 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399005127 acyl-activating enzyme (AAE) consensus motif; other site 290399005128 AMP binding site [chemical binding]; other site 290399005129 active site 290399005130 CoA binding site [chemical binding]; other site 290399005131 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 290399005132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399005133 active site 290399005134 phosphorylation site [posttranslational modification] 290399005135 intermolecular recognition site; other site 290399005136 dimerization interface [polypeptide binding]; other site 290399005137 FaeA-like protein; Region: FaeA; pfam04703 290399005138 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 290399005139 PAS domain; Region: PAS; smart00091 290399005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399005141 ATP binding site [chemical binding]; other site 290399005142 Mg2+ binding site [ion binding]; other site 290399005143 G-X-G motif; other site 290399005144 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290399005145 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290399005146 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290399005147 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399005148 P-loop; other site 290399005149 Magnesium ion binding site [ion binding]; other site 290399005150 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399005151 Magnesium ion binding site [ion binding]; other site 290399005152 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 290399005153 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 290399005154 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 290399005155 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290399005156 RNA binding surface [nucleotide binding]; other site 290399005157 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 290399005158 active site 290399005159 prephenate dehydrogenase; Validated; Region: PRK06545 290399005160 prephenate dehydrogenase; Validated; Region: PRK08507 290399005161 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290399005162 cytidylate kinase; Provisional; Region: cmk; PRK00023 290399005163 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 290399005164 CMP-binding site; other site 290399005165 The sites determining sugar specificity; other site 290399005166 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290399005167 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290399005168 putative acyl-acceptor binding pocket; other site 290399005169 GTP-binding protein Der; Reviewed; Region: PRK03003 290399005170 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 290399005171 G1 box; other site 290399005172 GTP/Mg2+ binding site [chemical binding]; other site 290399005173 Switch I region; other site 290399005174 G2 box; other site 290399005175 Switch II region; other site 290399005176 G3 box; other site 290399005177 G4 box; other site 290399005178 G5 box; other site 290399005179 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 290399005180 G1 box; other site 290399005181 GTP/Mg2+ binding site [chemical binding]; other site 290399005182 Switch I region; other site 290399005183 G2 box; other site 290399005184 G3 box; other site 290399005185 Switch II region; other site 290399005186 G4 box; other site 290399005187 G5 box; other site 290399005188 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290399005189 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 290399005190 putative DNA binding site [nucleotide binding]; other site 290399005191 catalytic residue [active] 290399005192 putative H2TH interface [polypeptide binding]; other site 290399005193 putative catalytic residues [active] 290399005194 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290399005195 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 290399005196 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290399005197 lipoyl attachment site [posttranslational modification]; other site 290399005198 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 290399005199 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290399005200 phosphopeptide binding site; other site 290399005201 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 290399005202 DNA binding residues [nucleotide binding] 290399005203 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290399005204 dimer interface [polypeptide binding]; other site 290399005205 Bifunctional nuclease; Region: DNase-RNase; pfam02577 290399005206 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 290399005207 DNA binding residues [nucleotide binding] 290399005208 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290399005209 putative dimer interface [polypeptide binding]; other site 290399005210 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290399005211 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399005212 Magnesium ion binding site [ion binding]; other site 290399005213 pyruvate carboxylase; Reviewed; Region: PRK12999 290399005214 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290399005215 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290399005216 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290399005217 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290399005218 active site 290399005219 catalytic residues [active] 290399005220 metal binding site [ion binding]; metal-binding site 290399005221 homodimer binding site [polypeptide binding]; other site 290399005222 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290399005223 carboxyltransferase (CT) interaction site; other site 290399005224 biotinylation site [posttranslational modification]; other site 290399005225 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290399005226 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 290399005227 acyl-activating enzyme (AAE) consensus motif; other site 290399005228 putative AMP binding site [chemical binding]; other site 290399005229 putative active site [active] 290399005230 putative CoA binding site [chemical binding]; other site 290399005231 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 290399005232 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290399005233 nucleotide binding site [chemical binding]; other site 290399005234 Esterase/lipase [General function prediction only]; Region: COG1647 290399005235 Esterase/lipase [General function prediction only]; Region: COG1647 290399005236 Secretory lipase; Region: LIP; pfam03583 290399005237 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290399005238 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290399005239 putative acyl-acceptor binding pocket; other site 290399005240 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 290399005241 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399005242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399005243 active site 290399005244 ATP binding site [chemical binding]; other site 290399005245 substrate binding site [chemical binding]; other site 290399005246 activation loop (A-loop); other site 290399005247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 290399005248 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399005249 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399005250 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399005251 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290399005252 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290399005253 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290399005254 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290399005255 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290399005256 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 290399005257 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290399005258 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290399005259 catalytic residue [active] 290399005260 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290399005261 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290399005262 substrate binding pocket [chemical binding]; other site 290399005263 chain length determination region; other site 290399005264 substrate-Mg2+ binding site; other site 290399005265 catalytic residues [active] 290399005266 aspartate-rich region 1; other site 290399005267 active site lid residues [active] 290399005268 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 290399005269 aspartate-rich region 2; other site 290399005270 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290399005271 active site 290399005272 DNA polymerase IV; Validated; Region: PRK02406 290399005273 DNA binding site [nucleotide binding] 290399005274 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290399005275 cell division protein MraZ; Reviewed; Region: PRK00326 290399005276 MraZ protein; Region: MraZ; pfam02381 290399005277 MraZ protein; Region: MraZ; pfam02381 290399005278 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 290399005279 MraW methylase family; Region: Methyltransf_5; cl17771 290399005280 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 290399005281 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290399005282 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290399005283 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 290399005284 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290399005285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290399005286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290399005287 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 290399005288 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290399005289 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290399005290 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290399005291 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 290399005292 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 290399005293 Mg++ binding site [ion binding]; other site 290399005294 putative catalytic motif [active] 290399005295 putative substrate binding site [chemical binding]; other site 290399005296 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 290399005297 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 290399005298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290399005299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290399005300 cell division protein FtsW; Region: ftsW; TIGR02614 290399005301 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 290399005302 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 290399005303 active site 290399005304 homodimer interface [polypeptide binding]; other site 290399005305 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 290399005306 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290399005307 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290399005308 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290399005309 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 290399005310 Cell division protein FtsQ; Region: FtsQ; pfam03799 290399005311 cell division protein FtsZ; Validated; Region: PRK09330 290399005312 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 290399005313 nucleotide binding site [chemical binding]; other site 290399005314 SulA interaction site; other site 290399005315 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 290399005316 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 290399005317 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 290399005318 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290399005319 catalytic residue [active] 290399005320 Protein of unknown function (DUF552); Region: DUF552; pfam04472 290399005321 DivIVA protein; Region: DivIVA; pfam05103 290399005322 DivIVA domain; Region: DivI1A_domain; TIGR03544 290399005323 lipoprotein signal peptidase; Provisional; Region: PRK14772 290399005324 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290399005325 S4 RNA-binding domain; Region: S4; smart00363 290399005326 RNA binding surface [nucleotide binding]; other site 290399005327 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290399005328 active site 290399005329 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 290399005330 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 290399005331 active site 290399005332 PHP Thumb interface [polypeptide binding]; other site 290399005333 metal binding site [ion binding]; metal-binding site 290399005334 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290399005335 generic binding surface II; other site 290399005336 generic binding surface I; other site 290399005337 pteridine reductase; Provisional; Region: PRK09135 290399005338 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 290399005339 NADP binding site [chemical binding]; other site 290399005340 homodimer interface [polypeptide binding]; other site 290399005341 active site 290399005342 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290399005343 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 290399005344 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290399005345 NAD binding site [chemical binding]; other site 290399005346 dimerization interface [polypeptide binding]; other site 290399005347 product binding site; other site 290399005348 substrate binding site [chemical binding]; other site 290399005349 zinc binding site [ion binding]; other site 290399005350 catalytic residues [active] 290399005351 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 290399005352 ATP cone domain; Region: ATP-cone; pfam03477 290399005353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399005354 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 290399005355 NAD(P) binding site [chemical binding]; other site 290399005356 active site 290399005357 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399005358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290399005359 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290399005360 active site 290399005361 Sporulation related domain; Region: SPOR; cl10051 290399005362 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 290399005363 oligomerization interface [polypeptide binding]; other site 290399005364 active site 290399005365 metal binding site [ion binding]; metal-binding site 290399005366 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 290399005367 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290399005368 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290399005369 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 290399005370 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290399005371 metal binding triad; other site 290399005372 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290399005373 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290399005374 metal binding triad; other site 290399005375 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 290399005376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290399005377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399005378 substrate binding pocket [chemical binding]; other site 290399005379 membrane-bound complex binding site; other site 290399005380 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 290399005381 hinge residues; other site 290399005382 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290399005383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399005384 dimer interface [polypeptide binding]; other site 290399005385 conserved gate region; other site 290399005386 putative PBP binding loops; other site 290399005387 ABC-ATPase subunit interface; other site 290399005388 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399005389 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290399005390 Walker A/P-loop; other site 290399005391 ATP binding site [chemical binding]; other site 290399005392 Q-loop/lid; other site 290399005393 ABC transporter signature motif; other site 290399005394 Walker B; other site 290399005395 D-loop; other site 290399005396 H-loop/switch region; other site 290399005397 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 290399005398 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399005399 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290399005400 glutamine synthetase, type I; Region: GlnA; TIGR00653 290399005401 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 290399005402 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290399005403 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 290399005404 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 290399005405 lipoyl synthase; Provisional; Region: PRK05481 290399005406 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399005407 FeS/SAM binding site; other site 290399005408 lipoate-protein ligase B; Provisional; Region: PRK14345 290399005409 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399005410 active site 290399005411 ATP binding site [chemical binding]; other site 290399005412 substrate binding site [chemical binding]; other site 290399005413 activation loop (A-loop); other site 290399005414 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399005415 TIGR01777 family protein; Region: yfcH 290399005416 NAD(P) binding site [chemical binding]; other site 290399005417 active site 290399005418 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 290399005419 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290399005420 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 290399005421 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 290399005422 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290399005423 protein binding site [polypeptide binding]; other site 290399005424 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 290399005425 Domain interface; other site 290399005426 Peptide binding site; other site 290399005427 Active site tetrad [active] 290399005428 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 290399005429 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290399005430 E3 interaction surface; other site 290399005431 lipoyl attachment site [posttranslational modification]; other site 290399005432 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290399005433 E3 interaction surface; other site 290399005434 lipoyl attachment site [posttranslational modification]; other site 290399005435 e3 binding domain; Region: E3_binding; pfam02817 290399005436 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290399005437 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290399005438 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290399005439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399005440 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399005441 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290399005442 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290399005443 interface (dimer of trimers) [polypeptide binding]; other site 290399005444 Substrate-binding/catalytic site; other site 290399005445 Zn-binding sites [ion binding]; other site 290399005446 PAC2 family; Region: PAC2; pfam09754 290399005447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399005448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399005449 putative substrate translocation pore; other site 290399005450 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 290399005451 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 290399005452 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290399005453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399005454 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290399005455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399005456 DNA binding residues [nucleotide binding] 290399005457 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 290399005458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399005459 ATP binding site [chemical binding]; other site 290399005460 Mg2+ binding site [ion binding]; other site 290399005461 G-X-G motif; other site 290399005462 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290399005463 anchoring element; other site 290399005464 dimer interface [polypeptide binding]; other site 290399005465 ATP binding site [chemical binding]; other site 290399005466 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 290399005467 active site 290399005468 metal binding site [ion binding]; metal-binding site 290399005469 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290399005470 Peptidase family M48; Region: Peptidase_M48; cl12018 290399005471 Penicillinase repressor; Region: Pencillinase_R; cl17580 290399005472 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 290399005473 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290399005474 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290399005475 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290399005476 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 290399005477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399005478 Walker A/P-loop; other site 290399005479 ATP binding site [chemical binding]; other site 290399005480 Q-loop/lid; other site 290399005481 ABC transporter signature motif; other site 290399005482 Walker B; other site 290399005483 D-loop; other site 290399005484 H-loop/switch region; other site 290399005485 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 290399005486 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 290399005487 Walker A/P-loop; other site 290399005488 ATP binding site [chemical binding]; other site 290399005489 Q-loop/lid; other site 290399005490 ABC transporter signature motif; other site 290399005491 Walker B; other site 290399005492 D-loop; other site 290399005493 H-loop/switch region; other site 290399005494 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 290399005495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399005496 Coenzyme A binding pocket [chemical binding]; other site 290399005497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399005498 Coenzyme A binding pocket [chemical binding]; other site 290399005499 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 290399005500 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290399005501 CAP-like domain; other site 290399005502 active site 290399005503 primary dimer interface [polypeptide binding]; other site 290399005504 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290399005505 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 290399005506 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399005507 Coenzyme A binding pocket [chemical binding]; other site 290399005508 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 290399005509 CoA binding domain; Region: CoA_binding_2; pfam13380 290399005510 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 290399005511 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 290399005512 Uncharacterized conserved protein [Function unknown]; Region: COG3379 290399005513 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 290399005514 PglZ domain; Region: PglZ; pfam08665 290399005515 thymidine kinase; Provisional; Region: PRK04296 290399005516 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 290399005517 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 290399005518 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290399005519 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 290399005520 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290399005521 trimer interface [polypeptide binding]; other site 290399005522 active site 290399005523 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 290399005524 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 290399005525 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290399005526 TrkA-N domain; Region: TrkA_N; pfam02254 290399005527 TrkA-C domain; Region: TrkA_C; pfam02080 290399005528 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290399005529 TrkA-N domain; Region: TrkA_N; pfam02254 290399005530 TrkA-C domain; Region: TrkA_C; pfam02080 290399005531 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290399005532 TRAM domain; Region: TRAM; pfam01938 290399005533 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 290399005534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399005535 S-adenosylmethionine binding site [chemical binding]; other site 290399005536 aconitate hydratase; Validated; Region: PRK09277 290399005537 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290399005538 substrate binding site [chemical binding]; other site 290399005539 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290399005540 ligand binding site [chemical binding]; other site 290399005541 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 290399005542 substrate binding site [chemical binding]; other site 290399005543 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 290399005544 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 290399005545 TPP-binding site [chemical binding]; other site 290399005546 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290399005547 PYR/PP interface [polypeptide binding]; other site 290399005548 dimer interface [polypeptide binding]; other site 290399005549 TPP binding site [chemical binding]; other site 290399005550 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399005551 Protein of unknown function (DUF402); Region: DUF402; cl00979 290399005552 hypothetical protein; Provisional; Region: PRK07758 290399005553 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399005554 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399005555 active site 290399005556 catalytic tetrad [active] 290399005557 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 290399005558 active site 290399005559 Cobalt transport protein; Region: CbiQ; cl00463 290399005560 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399005561 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399005562 Walker A/P-loop; other site 290399005563 ATP binding site [chemical binding]; other site 290399005564 Q-loop/lid; other site 290399005565 ABC transporter signature motif; other site 290399005566 Walker B; other site 290399005567 D-loop; other site 290399005568 H-loop/switch region; other site 290399005569 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399005570 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290399005571 Walker A/P-loop; other site 290399005572 ATP binding site [chemical binding]; other site 290399005573 Q-loop/lid; other site 290399005574 ABC transporter signature motif; other site 290399005575 Walker B; other site 290399005576 D-loop; other site 290399005577 H-loop/switch region; other site 290399005578 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 290399005579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399005580 substrate binding site [chemical binding]; other site 290399005581 oxyanion hole (OAH) forming residues; other site 290399005582 trimer interface [polypeptide binding]; other site 290399005583 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290399005584 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290399005585 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290399005586 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290399005587 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 290399005588 dimer interface [polypeptide binding]; other site 290399005589 active site 290399005590 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 290399005591 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 290399005592 catalytic site [active] 290399005593 putative active site [active] 290399005594 putative substrate binding site [chemical binding]; other site 290399005595 Helicase and RNase D C-terminal; Region: HRDC; smart00341 290399005596 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 290399005597 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 290399005598 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 290399005599 tetramer interface [polypeptide binding]; other site 290399005600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399005601 catalytic residue [active] 290399005602 classical (c) SDRs; Region: SDR_c; cd05233 290399005603 NAD(P) binding site [chemical binding]; other site 290399005604 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 290399005605 SelR domain; Region: SelR; pfam01641 290399005606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399005607 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290399005608 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 290399005609 putative deacylase active site [active] 290399005610 Fe-S metabolism associated domain; Region: SufE; cl00951 290399005611 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290399005612 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290399005613 active site residue [active] 290399005614 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290399005615 active site residue [active] 290399005616 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 290399005617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290399005618 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 290399005619 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 290399005620 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290399005621 active site 290399005622 catalytic residues [active] 290399005623 metal binding site [ion binding]; metal-binding site 290399005624 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 290399005625 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 290399005626 putative active site [active] 290399005627 substrate binding site [chemical binding]; other site 290399005628 putative cosubstrate binding site; other site 290399005629 catalytic site [active] 290399005630 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 290399005631 substrate binding site [chemical binding]; other site 290399005632 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 290399005633 putative RNA binding site [nucleotide binding]; other site 290399005634 16S rRNA methyltransferase B; Provisional; Region: PRK14902 290399005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399005636 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 290399005637 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290399005638 substrate binding site [chemical binding]; other site 290399005639 hexamer interface [polypeptide binding]; other site 290399005640 metal binding site [ion binding]; metal-binding site 290399005641 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 290399005642 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 290399005643 catalytic motif [active] 290399005644 Zn binding site [ion binding]; other site 290399005645 RibD C-terminal domain; Region: RibD_C; cl17279 290399005646 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 290399005647 Lumazine binding domain; Region: Lum_binding; pfam00677 290399005648 Lumazine binding domain; Region: Lum_binding; pfam00677 290399005649 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 290399005650 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 290399005651 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 290399005652 dimerization interface [polypeptide binding]; other site 290399005653 active site 290399005654 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 290399005655 homopentamer interface [polypeptide binding]; other site 290399005656 active site 290399005657 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 290399005658 metal binding site [ion binding]; metal-binding site 290399005659 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 290399005660 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 290399005661 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 290399005662 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 290399005663 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290399005664 substrate binding site [chemical binding]; other site 290399005665 glutamase interaction surface [polypeptide binding]; other site 290399005666 TIGR03085 family protein; Region: TIGR03085 290399005667 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 290399005668 anthranilate synthase component I; Provisional; Region: PRK13571 290399005669 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290399005670 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290399005671 Protein of unknown function (DUF2422); Region: DUF2422; pfam10337 290399005672 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 290399005673 active site 290399005674 ribulose/triose binding site [chemical binding]; other site 290399005675 phosphate binding site [ion binding]; other site 290399005676 substrate (anthranilate) binding pocket [chemical binding]; other site 290399005677 product (indole) binding pocket [chemical binding]; other site 290399005678 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 290399005679 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290399005680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399005681 catalytic residue [active] 290399005682 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 290399005683 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 290399005684 substrate binding site [chemical binding]; other site 290399005685 active site 290399005686 catalytic residues [active] 290399005687 heterodimer interface [polypeptide binding]; other site 290399005688 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290399005689 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 290399005690 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 290399005691 active site 290399005692 dimer interface [polypeptide binding]; other site 290399005693 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 290399005694 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290399005695 active site 290399005696 FMN binding site [chemical binding]; other site 290399005697 substrate binding site [chemical binding]; other site 290399005698 3Fe-4S cluster binding site [ion binding]; other site 290399005699 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 290399005700 domain interface; other site 290399005701 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 290399005702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399005703 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 290399005704 pyruvate kinase; Provisional; Region: PRK06247 290399005705 domain interfaces; other site 290399005706 active site 290399005707 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 290399005708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399005709 active site 290399005710 phosphorylation site [posttranslational modification] 290399005711 intermolecular recognition site; other site 290399005712 dimerization interface [polypeptide binding]; other site 290399005713 ANTAR domain; Region: ANTAR; pfam03861 290399005714 Domain of unknown function (DUF202); Region: DUF202; cl09954 290399005715 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290399005716 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 290399005717 substrate binding site [chemical binding]; other site 290399005718 catalytic residues [active] 290399005719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399005720 DNA-binding site [nucleotide binding]; DNA binding site 290399005721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399005722 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399005723 dimerization interface [polypeptide binding]; other site 290399005724 ligand binding site [chemical binding]; other site 290399005725 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290399005726 Sulfatase; Region: Sulfatase; cl17466 290399005727 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290399005728 Sulfatase; Region: Sulfatase; cl17466 290399005729 CutC family; Region: CutC; cl01218 290399005730 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 290399005731 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399005732 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399005733 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399005734 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399005735 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399005736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399005737 dimer interface [polypeptide binding]; other site 290399005738 conserved gate region; other site 290399005739 putative PBP binding loops; other site 290399005740 ABC-ATPase subunit interface; other site 290399005741 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399005742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399005743 dimer interface [polypeptide binding]; other site 290399005744 conserved gate region; other site 290399005745 putative PBP binding loops; other site 290399005746 ABC-ATPase subunit interface; other site 290399005747 Sulfatase; Region: Sulfatase; cl17466 290399005748 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290399005749 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 290399005750 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290399005751 dimer interface [polypeptide binding]; other site 290399005752 active site 290399005753 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290399005754 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399005755 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290399005756 nucleotide binding site [chemical binding]; other site 290399005757 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 290399005758 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290399005759 putative substrate binding site [chemical binding]; other site 290399005760 putative ATP binding site [chemical binding]; other site 290399005761 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290399005762 intersubunit interface [polypeptide binding]; other site 290399005763 active site 290399005764 zinc binding site [ion binding]; other site 290399005765 Na+ binding site [ion binding]; other site 290399005766 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 290399005767 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399005768 active site 290399005769 Uncharacterized conserved protein [Function unknown]; Region: COG1262 290399005770 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 290399005771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399005772 putative DNA binding site [nucleotide binding]; other site 290399005773 putative Zn2+ binding site [ion binding]; other site 290399005774 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290399005775 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399005776 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 290399005777 Sulfatase; Region: Sulfatase; cl17466 290399005778 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 290399005779 Domain of unknown function (DUF202); Region: DUF202; pfam02656 290399005780 Domain of unknown function (DUF202); Region: DUF202; cl09954 290399005781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399005782 D-galactonate transporter; Region: 2A0114; TIGR00893 290399005783 putative substrate translocation pore; other site 290399005784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399005785 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399005786 putative substrate translocation pore; other site 290399005787 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 290399005788 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399005789 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290399005790 NAD(P) binding site [chemical binding]; other site 290399005791 catalytic residues [active] 290399005792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399005793 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290399005794 NAD(P) binding site [chemical binding]; other site 290399005795 active site 290399005796 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399005797 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399005798 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399005799 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290399005800 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 290399005801 FMN-binding pocket [chemical binding]; other site 290399005802 flavin binding motif; other site 290399005803 phosphate binding motif [ion binding]; other site 290399005804 beta-alpha-beta structure motif; other site 290399005805 NAD binding pocket [chemical binding]; other site 290399005806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290399005807 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290399005808 catalytic loop [active] 290399005809 iron binding site [ion binding]; other site 290399005810 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290399005811 Cytochrome P450; Region: p450; cl12078 290399005812 hypothetical protein; Provisional; Region: PRK07588 290399005813 hypothetical protein; Provisional; Region: PRK07236 290399005814 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399005815 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 290399005816 dimerization interface [polypeptide binding]; other site 290399005817 Predicted membrane protein [Function unknown]; Region: COG4325 290399005818 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 290399005819 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290399005820 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290399005821 RNA binding site [nucleotide binding]; other site 290399005822 Subtilisin inhibitor-like; Region: SSI; cl11594 290399005823 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290399005824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399005825 Ligand Binding Site [chemical binding]; other site 290399005826 potassium/proton antiporter; Reviewed; Region: PRK05326 290399005827 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399005828 Ligand Binding Site [chemical binding]; other site 290399005829 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290399005830 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 290399005831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399005832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399005833 motif II; other site 290399005834 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290399005835 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290399005836 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 290399005837 hexamer interface [polypeptide binding]; other site 290399005838 ligand binding site [chemical binding]; other site 290399005839 putative active site [active] 290399005840 NAD(P) binding site [chemical binding]; other site 290399005841 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 290399005842 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399005843 substrate binding pocket [chemical binding]; other site 290399005844 membrane-bound complex binding site; other site 290399005845 hinge residues; other site 290399005846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399005847 dimer interface [polypeptide binding]; other site 290399005848 conserved gate region; other site 290399005849 putative PBP binding loops; other site 290399005850 ABC-ATPase subunit interface; other site 290399005851 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 290399005852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399005853 dimer interface [polypeptide binding]; other site 290399005854 conserved gate region; other site 290399005855 putative PBP binding loops; other site 290399005856 ABC-ATPase subunit interface; other site 290399005857 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399005858 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290399005859 Walker A/P-loop; other site 290399005860 ATP binding site [chemical binding]; other site 290399005861 Q-loop/lid; other site 290399005862 ABC transporter signature motif; other site 290399005863 Walker B; other site 290399005864 D-loop; other site 290399005865 H-loop/switch region; other site 290399005866 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290399005867 homotrimer interaction site [polypeptide binding]; other site 290399005868 putative active site [active] 290399005869 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290399005870 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290399005871 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399005872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399005873 DNA-binding site [nucleotide binding]; DNA binding site 290399005874 FCD domain; Region: FCD; pfam07729 290399005875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399005876 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399005877 putative substrate translocation pore; other site 290399005878 putative amidase; Provisional; Region: PRK06169 290399005879 Amidase; Region: Amidase; pfam01425 290399005880 succinic semialdehyde dehydrogenase; Region: PLN02278 290399005881 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290399005882 tetramerization interface [polypeptide binding]; other site 290399005883 NAD(P) binding site [chemical binding]; other site 290399005884 catalytic residues [active] 290399005885 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290399005886 FAD binding domain; Region: FAD_binding_4; pfam01565 290399005887 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290399005888 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 290399005889 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290399005890 inhibitor-cofactor binding pocket; inhibition site 290399005891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399005892 catalytic residue [active] 290399005893 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290399005894 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 290399005895 NAD binding site [chemical binding]; other site 290399005896 ligand binding site [chemical binding]; other site 290399005897 catalytic site [active] 290399005898 acetyl-CoA synthetase; Provisional; Region: PRK00174 290399005899 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290399005900 active site 290399005901 CoA binding site [chemical binding]; other site 290399005902 acyl-activating enzyme (AAE) consensus motif; other site 290399005903 AMP binding site [chemical binding]; other site 290399005904 acetate binding site [chemical binding]; other site 290399005905 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 290399005906 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 290399005907 active site 290399005908 multimer interface [polypeptide binding]; other site 290399005909 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 290399005910 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 290399005911 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 290399005912 metal binding site [ion binding]; metal-binding site 290399005913 dimer interface [polypeptide binding]; other site 290399005914 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290399005915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399005916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399005917 homodimer interface [polypeptide binding]; other site 290399005918 catalytic residue [active] 290399005919 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 290399005920 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290399005921 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 290399005922 active site 290399005923 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290399005924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290399005925 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290399005926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399005927 ATP binding site [chemical binding]; other site 290399005928 Mg2+ binding site [ion binding]; other site 290399005929 G-X-G motif; other site 290399005930 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399005931 PAS domain; Region: PAS_9; pfam13426 290399005932 putative active site [active] 290399005933 heme pocket [chemical binding]; other site 290399005934 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399005935 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 290399005936 putative binding surface; other site 290399005937 active site 290399005938 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399005939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399005940 active site 290399005941 phosphorylation site [posttranslational modification] 290399005942 intermolecular recognition site; other site 290399005943 dimerization interface [polypeptide binding]; other site 290399005944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399005945 DNA binding site [nucleotide binding] 290399005946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399005947 dimer interface [polypeptide binding]; other site 290399005948 phosphorylation site [posttranslational modification] 290399005949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399005950 ATP binding site [chemical binding]; other site 290399005951 Mg2+ binding site [ion binding]; other site 290399005952 G-X-G motif; other site 290399005953 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 290399005954 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 290399005955 DNA binding residues [nucleotide binding] 290399005956 dimer interface [polypeptide binding]; other site 290399005957 metal binding site [ion binding]; metal-binding site 290399005958 mercuric reductase; Region: MerA; TIGR02053 290399005959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399005960 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290399005961 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290399005962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399005963 Walker A motif; other site 290399005964 ATP binding site [chemical binding]; other site 290399005965 Walker B motif; other site 290399005966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290399005967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399005968 Response regulator receiver domain; Region: Response_reg; pfam00072 290399005969 active site 290399005970 phosphorylation site [posttranslational modification] 290399005971 intermolecular recognition site; other site 290399005972 dimerization interface [polypeptide binding]; other site 290399005973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 290399005974 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 290399005975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399005976 putative active site [active] 290399005977 heme pocket [chemical binding]; other site 290399005978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399005979 putative active site [active] 290399005980 heme pocket [chemical binding]; other site 290399005981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399005982 putative active site [active] 290399005983 heme pocket [chemical binding]; other site 290399005984 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290399005985 metal binding site [ion binding]; metal-binding site 290399005986 active site 290399005987 I-site; other site 290399005988 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399005989 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 290399005990 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399005991 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290399005992 tetramerization interface [polypeptide binding]; other site 290399005993 NAD(P) binding site [chemical binding]; other site 290399005994 catalytic residues [active] 290399005995 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290399005996 classical (c) SDRs; Region: SDR_c; cd05233 290399005997 NAD(P) binding site [chemical binding]; other site 290399005998 active site 290399005999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399006000 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399006001 putative substrate translocation pore; other site 290399006002 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 290399006003 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290399006004 putative NAD(P) binding site [chemical binding]; other site 290399006005 catalytic Zn binding site [ion binding]; other site 290399006006 structural Zn binding site [ion binding]; other site 290399006007 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290399006008 classical (c) SDRs; Region: SDR_c; cd05233 290399006009 NAD(P) binding site [chemical binding]; other site 290399006010 active site 290399006011 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 290399006012 putative substrate binding site [chemical binding]; other site 290399006013 putative ATP binding site [chemical binding]; other site 290399006014 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290399006015 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290399006016 PYR/PP interface [polypeptide binding]; other site 290399006017 dimer interface [polypeptide binding]; other site 290399006018 TPP binding site [chemical binding]; other site 290399006019 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399006020 transketolase; Reviewed; Region: PRK05899 290399006021 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290399006022 TPP-binding site [chemical binding]; other site 290399006023 dimer interface [polypeptide binding]; other site 290399006024 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399006025 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290399006026 NAD(P) binding site [chemical binding]; other site 290399006027 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399006028 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399006029 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399006030 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399006031 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399006032 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399006033 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 290399006034 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290399006035 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290399006036 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290399006037 putative active site [active] 290399006038 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 290399006039 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290399006040 putative ligand binding site [chemical binding]; other site 290399006041 putative NAD binding site [chemical binding]; other site 290399006042 catalytic site [active] 290399006043 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 290399006044 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 290399006045 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 290399006046 glycerol kinase; Provisional; Region: glpK; PRK00047 290399006047 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 290399006048 N- and C-terminal domain interface [polypeptide binding]; other site 290399006049 active site 290399006050 MgATP binding site [chemical binding]; other site 290399006051 catalytic site [active] 290399006052 metal binding site [ion binding]; metal-binding site 290399006053 glycerol binding site [chemical binding]; other site 290399006054 homotetramer interface [polypeptide binding]; other site 290399006055 homodimer interface [polypeptide binding]; other site 290399006056 FBP binding site [chemical binding]; other site 290399006057 protein IIAGlc interface [polypeptide binding]; other site 290399006058 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399006059 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 290399006060 putative NAD(P) binding site [chemical binding]; other site 290399006061 catalytic Zn binding site [ion binding]; other site 290399006062 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399006063 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 290399006064 putative NAD(P) binding site [chemical binding]; other site 290399006065 catalytic Zn binding site [ion binding]; other site 290399006066 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290399006067 classical (c) SDRs; Region: SDR_c; cd05233 290399006068 NAD(P) binding site [chemical binding]; other site 290399006069 active site 290399006070 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 290399006071 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290399006072 active site 290399006073 intersubunit interface [polypeptide binding]; other site 290399006074 catalytic residue [active] 290399006075 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 290399006076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290399006077 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290399006078 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290399006079 glutaminase active site [active] 290399006080 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290399006081 dimer interface [polypeptide binding]; other site 290399006082 active site 290399006083 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290399006084 dimer interface [polypeptide binding]; other site 290399006085 active site 290399006086 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290399006087 ligand binding site [chemical binding]; other site 290399006088 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290399006089 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290399006090 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290399006091 Walker A/P-loop; other site 290399006092 ATP binding site [chemical binding]; other site 290399006093 Q-loop/lid; other site 290399006094 ABC transporter signature motif; other site 290399006095 Walker B; other site 290399006096 D-loop; other site 290399006097 H-loop/switch region; other site 290399006098 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290399006099 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399006100 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399006101 TM-ABC transporter signature motif; other site 290399006102 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290399006103 classical (c) SDRs; Region: SDR_c; cd05233 290399006104 NAD(P) binding site [chemical binding]; other site 290399006105 active site 290399006106 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 290399006107 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 290399006108 ligand binding site [chemical binding]; other site 290399006109 homodimer interface [polypeptide binding]; other site 290399006110 NAD(P) binding site [chemical binding]; other site 290399006111 trimer interface B [polypeptide binding]; other site 290399006112 trimer interface A [polypeptide binding]; other site 290399006113 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 290399006114 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 290399006115 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 290399006116 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 290399006117 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290399006118 MFS transport protein AraJ; Provisional; Region: PRK10091 290399006119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399006120 putative substrate translocation pore; other site 290399006121 MarR family; Region: MarR_2; cl17246 290399006122 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290399006123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399006124 NAD(P) binding site [chemical binding]; other site 290399006125 active site 290399006126 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 290399006127 active site 290399006128 catalytic residues [active] 290399006129 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290399006130 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 290399006131 putative NAD(P) binding site [chemical binding]; other site 290399006132 catalytic Zn binding site [ion binding]; other site 290399006133 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 290399006134 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399006135 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 290399006136 putative NAD(P) binding site [chemical binding]; other site 290399006137 catalytic Zn binding site [ion binding]; other site 290399006138 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 290399006139 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 290399006140 putative ligand binding site [chemical binding]; other site 290399006141 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290399006142 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290399006143 Walker A/P-loop; other site 290399006144 ATP binding site [chemical binding]; other site 290399006145 Q-loop/lid; other site 290399006146 ABC transporter signature motif; other site 290399006147 Walker B; other site 290399006148 D-loop; other site 290399006149 H-loop/switch region; other site 290399006150 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290399006151 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399006152 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399006153 TM-ABC transporter signature motif; other site 290399006154 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 290399006155 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290399006156 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290399006157 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290399006158 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290399006159 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 290399006160 potential catalytic triad [active] 290399006161 conserved cys residue [active] 290399006162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399006163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399006164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290399006165 dimerization interface [polypeptide binding]; other site 290399006166 DDE domain; Region: DDE_Tnp_IS240; pfam13610 290399006167 Integrase core domain; Region: rve; pfam00665 290399006168 Integrase core domain; Region: rve_3; pfam13683 290399006169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399006170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399006171 DNA binding site [nucleotide binding] 290399006172 domain linker motif; other site 290399006173 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399006174 dimerization interface [polypeptide binding]; other site 290399006175 ligand binding site [chemical binding]; other site 290399006176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399006177 putative substrate translocation pore; other site 290399006178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399006179 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399006180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399006181 NAD(P) binding site [chemical binding]; other site 290399006182 active site 290399006183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399006184 active site 290399006185 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 290399006186 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 290399006187 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290399006188 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290399006189 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 290399006190 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 290399006191 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 290399006192 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 290399006193 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 290399006194 DDE domain; Region: DDE_Tnp_IS240; pfam13610 290399006195 Integrase core domain; Region: rve; pfam00665 290399006196 Integrase core domain; Region: rve_3; pfam13683 290399006197 Domain of unknown function (DUF336); Region: DUF336; cl01249 290399006198 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399006199 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399006200 DNA binding site [nucleotide binding] 290399006201 domain linker motif; other site 290399006202 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 290399006203 putative dimerization interface [polypeptide binding]; other site 290399006204 putative ligand binding site [chemical binding]; other site 290399006205 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 290399006206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399006207 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290399006208 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 290399006209 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399006210 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 290399006211 NAD(P) binding site [chemical binding]; other site 290399006212 catalytic residues [active] 290399006213 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399006214 enoyl-CoA hydratase; Provisional; Region: PRK06688 290399006215 substrate binding site [chemical binding]; other site 290399006216 oxyanion hole (OAH) forming residues; other site 290399006217 trimer interface [polypeptide binding]; other site 290399006218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 290399006219 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 290399006220 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 290399006221 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290399006222 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 290399006223 Coenzyme A transferase; Region: CoA_trans; smart00882 290399006224 Coenzyme A transferase; Region: CoA_trans; cl17247 290399006225 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399006226 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399006227 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399006228 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399006229 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399006230 DNA binding site [nucleotide binding] 290399006231 domain linker motif; other site 290399006232 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 290399006233 putative dimerization interface [polypeptide binding]; other site 290399006234 putative ligand binding site [chemical binding]; other site 290399006235 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399006236 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290399006237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399006238 putative PBP binding loops; other site 290399006239 ABC-ATPase subunit interface; other site 290399006240 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399006241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399006242 dimer interface [polypeptide binding]; other site 290399006243 conserved gate region; other site 290399006244 putative PBP binding loops; other site 290399006245 ABC-ATPase subunit interface; other site 290399006246 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399006247 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 290399006248 substrate binding site [chemical binding]; other site 290399006249 ATP binding site [chemical binding]; other site 290399006250 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 290399006251 active site 290399006252 intersubunit interface [polypeptide binding]; other site 290399006253 catalytic residue [active] 290399006254 stage V sporulation protein K; Region: spore_V_K; TIGR02881 290399006255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399006256 Walker A motif; other site 290399006257 ATP binding site [chemical binding]; other site 290399006258 Walker B motif; other site 290399006259 arginine finger; other site 290399006260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 290399006261 F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604 290399006262 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 290399006263 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 290399006264 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399006265 K+-transporting ATPase, c chain; Region: KdpC; cl00944 290399006266 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 290399006267 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 290399006268 Ligand Binding Site [chemical binding]; other site 290399006269 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 290399006270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399006271 dimer interface [polypeptide binding]; other site 290399006272 phosphorylation site [posttranslational modification] 290399006273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399006274 ATP binding site [chemical binding]; other site 290399006275 Mg2+ binding site [ion binding]; other site 290399006276 G-X-G motif; other site 290399006277 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 290399006278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399006279 active site 290399006280 phosphorylation site [posttranslational modification] 290399006281 intermolecular recognition site; other site 290399006282 dimerization interface [polypeptide binding]; other site 290399006283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399006284 DNA binding site [nucleotide binding] 290399006285 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290399006286 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290399006287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290399006288 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 290399006289 putative active site; other site 290399006290 putative metal binding residues [ion binding]; other site 290399006291 signature motif; other site 290399006292 putative triphosphate binding site [ion binding]; other site 290399006293 CHAD domain; Region: CHAD; pfam05235 290399006294 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 290399006295 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290399006296 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290399006297 dimerization domain swap beta strand [polypeptide binding]; other site 290399006298 regulatory protein interface [polypeptide binding]; other site 290399006299 active site 290399006300 regulatory phosphorylation site [posttranslational modification]; other site 290399006301 CAT RNA binding domain; Region: CAT_RBD; smart01061 290399006302 transcriptional antiterminator BglG; Provisional; Region: PRK09772 290399006303 PRD domain; Region: PRD; pfam00874 290399006304 PRD domain; Region: PRD; pfam00874 290399006305 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290399006306 beta-galactosidase; Region: BGL; TIGR03356 290399006307 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 290399006308 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 290399006309 active site turn [active] 290399006310 phosphorylation site [posttranslational modification] 290399006311 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290399006312 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 290399006313 HPr interaction site; other site 290399006314 glycerol kinase (GK) interaction site [polypeptide binding]; other site 290399006315 active site 290399006316 phosphorylation site [posttranslational modification] 290399006317 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 290399006318 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 290399006319 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 290399006320 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 290399006321 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399006322 NAD(P) binding site [chemical binding]; other site 290399006323 catalytic residues [active] 290399006324 benzoate transport; Region: 2A0115; TIGR00895 290399006325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399006326 putative substrate translocation pore; other site 290399006327 benzoylformate decarboxylase; Reviewed; Region: PRK07092 290399006328 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290399006329 PYR/PP interface [polypeptide binding]; other site 290399006330 dimer interface [polypeptide binding]; other site 290399006331 TPP binding site [chemical binding]; other site 290399006332 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399006333 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 290399006334 TPP-binding site [chemical binding]; other site 290399006335 dimer interface [polypeptide binding]; other site 290399006336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399006337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399006338 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 290399006339 substrate binding pocket [chemical binding]; other site 290399006340 dimerization interface [polypeptide binding]; other site 290399006341 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399006342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399006343 DNA-binding site [nucleotide binding]; DNA binding site 290399006344 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290399006345 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290399006346 active site pocket [active] 290399006347 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290399006348 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 290399006349 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290399006350 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290399006351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399006352 PAS domain; Region: PAS_9; pfam13426 290399006353 putative active site [active] 290399006354 heme pocket [chemical binding]; other site 290399006355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399006356 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290399006357 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399006358 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399006359 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 290399006360 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290399006361 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399006362 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399006363 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399006364 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399006365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399006366 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399006367 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399006368 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399006369 TM-ABC transporter signature motif; other site 290399006370 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290399006371 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290399006372 Walker A/P-loop; other site 290399006373 ATP binding site [chemical binding]; other site 290399006374 Q-loop/lid; other site 290399006375 ABC transporter signature motif; other site 290399006376 Walker B; other site 290399006377 D-loop; other site 290399006378 H-loop/switch region; other site 290399006379 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290399006380 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 290399006381 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290399006382 putative ligand binding site [chemical binding]; other site 290399006383 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399006384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399006385 DNA binding site [nucleotide binding] 290399006386 domain linker motif; other site 290399006387 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290399006388 ligand binding site [chemical binding]; other site 290399006389 dimerization interface (open form) [polypeptide binding]; other site 290399006390 dimerization interface (closed form) [polypeptide binding]; other site 290399006391 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290399006392 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290399006393 ligand binding site [chemical binding]; other site 290399006394 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290399006395 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290399006396 Walker A/P-loop; other site 290399006397 ATP binding site [chemical binding]; other site 290399006398 Q-loop/lid; other site 290399006399 ABC transporter signature motif; other site 290399006400 Walker B; other site 290399006401 D-loop; other site 290399006402 H-loop/switch region; other site 290399006403 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290399006404 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399006405 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399006406 TM-ABC transporter signature motif; other site 290399006407 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399006408 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399006409 active site 290399006410 catalytic tetrad [active] 290399006411 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 290399006412 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290399006413 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 290399006414 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399006415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399006416 DNA binding site [nucleotide binding] 290399006417 domain linker motif; other site 290399006418 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 290399006419 ligand binding site [chemical binding]; other site 290399006420 dimerization interface (open form) [polypeptide binding]; other site 290399006421 dimerization interface (closed form) [polypeptide binding]; other site 290399006422 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 290399006423 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290399006424 putative active site [active] 290399006425 catalytic triad [active] 290399006426 putative dimer interface [polypeptide binding]; other site 290399006427 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290399006428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399006429 FAD binding domain; Region: FAD_binding_3; pfam01494 290399006430 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399006431 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 290399006432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399006433 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 290399006434 dimerization interface [polypeptide binding]; other site 290399006435 substrate binding pocket [chemical binding]; other site 290399006436 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290399006437 Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315 290399006438 active site 290399006439 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 290399006440 catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438 290399006441 chlorocatechol 1,2-dioxygenases (1,2-CCDs) (type II enzymes) are homodimeric intradiol dioxygenases that degrade chlorocatechols via the addition of molecular oxygen and the subsequent cleavage between two adjacent hydroxyl groups. This reaction is part...; Region: 1,2-CCD; cd03462 290399006442 dimer interface [polypeptide binding]; other site 290399006443 active site 290399006444 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290399006445 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 290399006446 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 290399006447 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 290399006448 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 290399006449 active site 290399006450 dimer interface [polypeptide binding]; other site 290399006451 metal binding site [ion binding]; metal-binding site 290399006452 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 290399006453 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 290399006454 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 290399006455 hypothetical protein; Provisional; Region: PRK06834 290399006456 TrkA-N domain; Region: TrkA_N; pfam02254 290399006457 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399006458 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 290399006459 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 290399006460 Clostridial hydrophobic W; Region: ChW; pfam07538 290399006461 Clostridial hydrophobic W; Region: ChW; pfam07538 290399006462 Clostridial hydrophobic W; Region: ChW; pfam07538 290399006463 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 290399006464 Clostridial hydrophobic W; Region: ChW; pfam07538 290399006465 Clostridial hydrophobic W; Region: ChW; pfam07538 290399006466 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 290399006467 dimerization interface [polypeptide binding]; other site 290399006468 putative active cleft [active] 290399006469 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399006470 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 290399006471 tetramerization interface [polypeptide binding]; other site 290399006472 NAD(P) binding site [chemical binding]; other site 290399006473 catalytic residues [active] 290399006474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399006475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399006476 dimer interface [polypeptide binding]; other site 290399006477 conserved gate region; other site 290399006478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290399006479 ABC-ATPase subunit interface; other site 290399006480 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399006481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399006482 dimer interface [polypeptide binding]; other site 290399006483 conserved gate region; other site 290399006484 putative PBP binding loops; other site 290399006485 ABC-ATPase subunit interface; other site 290399006486 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399006487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399006488 Class I aldolases; Region: Aldolase_Class_I; cl17187 290399006489 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290399006490 substrate binding site [chemical binding]; other site 290399006491 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399006492 ATP binding site [chemical binding]; other site 290399006493 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399006494 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399006495 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399006496 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290399006497 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290399006498 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290399006499 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 290399006500 active site 290399006501 substrate binding site [chemical binding]; other site 290399006502 metal binding site [ion binding]; metal-binding site 290399006503 conserved hypothetical protein; Region: TIGR03843 290399006504 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 290399006505 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399006506 catalytic core [active] 290399006507 Amidohydrolase; Region: Amidohydro_2; pfam04909 290399006508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399006509 S-adenosylmethionine binding site [chemical binding]; other site 290399006510 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 290399006511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399006512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399006513 putative substrate translocation pore; other site 290399006514 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 290399006515 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 290399006516 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 290399006517 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 290399006518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399006519 non-specific DNA binding site [nucleotide binding]; other site 290399006520 salt bridge; other site 290399006521 sequence-specific DNA binding site [nucleotide binding]; other site 290399006522 Cupin domain; Region: Cupin_2; pfam07883 290399006523 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290399006524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399006525 S-adenosylmethionine binding site [chemical binding]; other site 290399006526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290399006527 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 290399006528 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 290399006529 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 290399006530 phosphoenolpyruvate synthase; Validated; Region: PRK06464 290399006531 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290399006532 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290399006533 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290399006534 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290399006535 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 290399006536 TspO/MBR family; Region: TspO_MBR; pfam03073 290399006537 hypothetical protein; Provisional; Region: PRK09256 290399006538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290399006539 Cytochrome P450; Region: p450; cl12078 290399006540 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290399006541 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290399006542 putative oxidoreductase; Provisional; Region: PRK11579 290399006543 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399006544 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399006545 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399006546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399006547 Walker A/P-loop; other site 290399006548 ATP binding site [chemical binding]; other site 290399006549 Q-loop/lid; other site 290399006550 ABC transporter signature motif; other site 290399006551 Walker B; other site 290399006552 D-loop; other site 290399006553 H-loop/switch region; other site 290399006554 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290399006555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399006556 dimer interface [polypeptide binding]; other site 290399006557 conserved gate region; other site 290399006558 putative PBP binding loops; other site 290399006559 ABC-ATPase subunit interface; other site 290399006560 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290399006561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399006562 substrate binding pocket [chemical binding]; other site 290399006563 membrane-bound complex binding site; other site 290399006564 hinge residues; other site 290399006565 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399006566 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399006567 DNA binding site [nucleotide binding] 290399006568 domain linker motif; other site 290399006569 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399006570 dimerization interface [polypeptide binding]; other site 290399006571 ligand binding site [chemical binding]; other site 290399006572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290399006573 PAS domain; Region: PAS_9; pfam13426 290399006574 putative active site [active] 290399006575 heme pocket [chemical binding]; other site 290399006576 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399006577 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 290399006578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399006579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 290399006580 Walker A/P-loop; other site 290399006581 ATP binding site [chemical binding]; other site 290399006582 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 290399006583 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290399006584 metal ion-dependent adhesion site (MIDAS); other site 290399006585 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399006586 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399006587 DNA-binding site [nucleotide binding]; DNA binding site 290399006588 FCD domain; Region: FCD; pfam07729 290399006589 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290399006590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399006591 Coenzyme A binding pocket [chemical binding]; other site 290399006592 adenylate kinase; Reviewed; Region: adk; PRK00279 290399006593 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290399006594 AMP-binding site [chemical binding]; other site 290399006595 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290399006596 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399006597 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290399006598 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399006599 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290399006600 Cytochrome P450; Region: p450; cl12078 290399006601 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290399006602 hypothetical protein; Provisional; Region: PRK08296 290399006603 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290399006604 short chain dehydrogenase; Provisional; Region: PRK12939 290399006605 classical (c) SDRs; Region: SDR_c; cd05233 290399006606 NAD(P) binding site [chemical binding]; other site 290399006607 active site 290399006608 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290399006609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290399006610 catalytic loop [active] 290399006611 iron binding site [ion binding]; other site 290399006612 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290399006613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399006614 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290399006615 Zn2+ binding site [ion binding]; other site 290399006616 Mg2+ binding site [ion binding]; other site 290399006617 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 290399006618 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399006619 NAD binding site [chemical binding]; other site 290399006620 catalytic residues [active] 290399006621 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290399006622 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290399006623 5'-3' exonuclease; Region: 53EXOc; smart00475 290399006624 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290399006625 active site 290399006626 metal binding site 1 [ion binding]; metal-binding site 290399006627 putative 5' ssDNA interaction site; other site 290399006628 metal binding site 3; metal-binding site 290399006629 metal binding site 2 [ion binding]; metal-binding site 290399006630 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290399006631 putative DNA binding site [nucleotide binding]; other site 290399006632 putative metal binding site [ion binding]; other site 290399006633 Yqey-like protein; Region: YqeY; pfam09424 290399006634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399006635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399006636 putative substrate translocation pore; other site 290399006637 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 290399006638 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 290399006639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399006640 active site 290399006641 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 290399006642 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290399006643 dimerization interface [polypeptide binding]; other site 290399006644 NAD binding site [chemical binding]; other site 290399006645 ligand binding site [chemical binding]; other site 290399006646 catalytic site [active] 290399006647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 290399006648 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 290399006649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290399006650 catalytic residue [active] 290399006651 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 290399006652 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290399006653 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290399006654 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 290399006655 CoA-transferase family III; Region: CoA_transf_3; pfam02515 290399006656 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 290399006657 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290399006658 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399006659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399006660 DNA-binding site [nucleotide binding]; DNA binding site 290399006661 FCD domain; Region: FCD; pfam07729 290399006662 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290399006663 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 290399006664 NADP binding site [chemical binding]; other site 290399006665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399006666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399006667 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290399006668 putative dimerization interface [polypeptide binding]; other site 290399006669 PrpF protein; Region: PrpF; pfam04303 290399006670 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 290399006671 Citrate transporter; Region: CitMHS; pfam03600 290399006672 DNA polymerase IV; Validated; Region: PRK03352 290399006673 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 290399006674 active site 290399006675 DNA binding site [nucleotide binding] 290399006676 Domain of unknown function (DUF427); Region: DUF427; pfam04248 290399006677 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399006678 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399006679 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399006680 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 290399006681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399006682 putative Mg++ binding site [ion binding]; other site 290399006683 nucleotide binding region [chemical binding]; other site 290399006684 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 290399006685 ATP-binding site [chemical binding]; other site 290399006686 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 290399006687 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 290399006688 Predicted transcriptional regulators [Transcription]; Region: COG1695 290399006689 Transcriptional regulator PadR-like family; Region: PadR; cl17335 290399006690 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 290399006691 elongation factor G; Reviewed; Region: PRK12740 290399006692 G1 box; other site 290399006693 putative GEF interaction site [polypeptide binding]; other site 290399006694 GTP/Mg2+ binding site [chemical binding]; other site 290399006695 Switch I region; other site 290399006696 G2 box; other site 290399006697 G3 box; other site 290399006698 Switch II region; other site 290399006699 G4 box; other site 290399006700 G5 box; other site 290399006701 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290399006702 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290399006703 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290399006704 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 290399006705 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 290399006706 trehalose synthase; Region: treS_nterm; TIGR02456 290399006707 active site 290399006708 catalytic site [active] 290399006709 Predicted eukaryotic-type DNA primase [DNA replication, recombination, and repair]; Region: COG3285 290399006710 nucleotide binding site [chemical binding]; other site 290399006711 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 290399006712 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 290399006713 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290399006714 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290399006715 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290399006716 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 290399006717 putative hydrophobic ligand binding site [chemical binding]; other site 290399006718 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 290399006719 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290399006720 metal ion-dependent adhesion site (MIDAS); other site 290399006721 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290399006722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399006723 Walker A motif; other site 290399006724 ATP binding site [chemical binding]; other site 290399006725 Walker B motif; other site 290399006726 arginine finger; other site 290399006727 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 290399006728 Ligand binding site; other site 290399006729 metal-binding site 290399006730 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 290399006731 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290399006732 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290399006733 Uncharacterized conserved protein [Function unknown]; Region: COG3350 290399006734 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 290399006735 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 290399006736 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 290399006737 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 290399006738 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 290399006739 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 290399006740 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 290399006741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399006742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 290399006743 dimerization interface [polypeptide binding]; other site 290399006744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399006745 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290399006746 dimer interface [polypeptide binding]; other site 290399006747 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290399006748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399006749 S-adenosylmethionine binding site [chemical binding]; other site 290399006750 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399006751 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399006752 dimerization interface [polypeptide binding]; other site 290399006753 DNA binding residues [nucleotide binding] 290399006754 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 290399006755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290399006756 Beta-Casp domain; Region: Beta-Casp; smart01027 290399006757 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 290399006758 Erythromycin esterase; Region: Erythro_esteras; pfam05139 290399006759 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399006760 Ligand Binding Site [chemical binding]; other site 290399006761 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399006762 Ligand Binding Site [chemical binding]; other site 290399006763 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 290399006764 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 290399006765 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290399006766 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290399006767 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 290399006768 Cupin domain; Region: Cupin_2; pfam07883 290399006769 Cupin domain; Region: Cupin_2; cl17218 290399006770 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399006771 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 290399006772 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399006773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399006774 putative substrate translocation pore; other site 290399006775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399006776 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399006777 salicylate hydroxylase; Provisional; Region: PRK08163 290399006778 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 290399006779 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 290399006780 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 290399006781 RibD C-terminal domain; Region: RibD_C; cl17279 290399006782 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290399006783 CoenzymeA binding site [chemical binding]; other site 290399006784 subunit interaction site [polypeptide binding]; other site 290399006785 PHB binding site; other site 290399006786 DNA polymerase I; Provisional; Region: PRK05755 290399006787 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290399006788 active site 290399006789 metal binding site 1 [ion binding]; metal-binding site 290399006790 putative 5' ssDNA interaction site; other site 290399006791 metal binding site 3; metal-binding site 290399006792 metal binding site 2 [ion binding]; metal-binding site 290399006793 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290399006794 putative DNA binding site [nucleotide binding]; other site 290399006795 putative metal binding site [ion binding]; other site 290399006796 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 290399006797 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 290399006798 active site 290399006799 DNA binding site [nucleotide binding] 290399006800 catalytic site [active] 290399006801 hypothetical protein; Provisional; Region: PRK01346 290399006802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 290399006803 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 290399006804 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 290399006805 RNA binding site [nucleotide binding]; other site 290399006806 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 290399006807 RNA binding site [nucleotide binding]; other site 290399006808 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290399006809 RNA binding site [nucleotide binding]; other site 290399006810 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290399006811 RNA binding site [nucleotide binding]; other site 290399006812 domain interface; other site 290399006813 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 290399006814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399006815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290399006816 Coenzyme A binding pocket [chemical binding]; other site 290399006817 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 290399006818 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 290399006819 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 290399006820 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 290399006821 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 290399006822 CoA-binding site [chemical binding]; other site 290399006823 ATP-binding [chemical binding]; other site 290399006824 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 290399006825 excinuclease ABC subunit B; Provisional; Region: PRK05298 290399006826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399006827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399006828 nucleotide binding region [chemical binding]; other site 290399006829 ATP-binding site [chemical binding]; other site 290399006830 Ultra-violet resistance protein B; Region: UvrB; pfam12344 290399006831 UvrB/uvrC motif; Region: UVR; pfam02151 290399006832 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290399006833 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 290399006834 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290399006835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399006836 Coenzyme A binding pocket [chemical binding]; other site 290399006837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399006838 ATP binding site [chemical binding]; other site 290399006839 putative Mg++ binding site [ion binding]; other site 290399006840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399006841 nucleotide binding region [chemical binding]; other site 290399006842 ATP-binding site [chemical binding]; other site 290399006843 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 290399006844 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 290399006845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399006846 S-adenosylmethionine binding site [chemical binding]; other site 290399006847 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399006848 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399006849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399006850 Walker A/P-loop; other site 290399006851 ATP binding site [chemical binding]; other site 290399006852 Q-loop/lid; other site 290399006853 ABC transporter signature motif; other site 290399006854 Walker B; other site 290399006855 D-loop; other site 290399006856 H-loop/switch region; other site 290399006857 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399006858 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399006859 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 290399006860 Walker A/P-loop; other site 290399006861 ATP binding site [chemical binding]; other site 290399006862 Q-loop/lid; other site 290399006863 ABC transporter signature motif; other site 290399006864 Walker B; other site 290399006865 D-loop; other site 290399006866 H-loop/switch region; other site 290399006867 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399006868 DNA-binding site [nucleotide binding]; DNA binding site 290399006869 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290399006870 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290399006871 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290399006872 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290399006873 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290399006874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399006875 motif II; other site 290399006876 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290399006877 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290399006878 putative acyl-acceptor binding pocket; other site 290399006879 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 290399006880 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290399006881 GIY-YIG motif/motif A; other site 290399006882 active site 290399006883 catalytic site [active] 290399006884 putative DNA binding site [nucleotide binding]; other site 290399006885 metal binding site [ion binding]; metal-binding site 290399006886 UvrB/uvrC motif; Region: UVR; pfam02151 290399006887 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 290399006888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290399006889 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 290399006890 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 290399006891 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 290399006892 putative substrate binding pocket [chemical binding]; other site 290399006893 dimer interface [polypeptide binding]; other site 290399006894 phosphate binding site [ion binding]; other site 290399006895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 290399006896 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 290399006897 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 290399006898 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290399006899 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290399006900 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 290399006901 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290399006902 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290399006903 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 290399006904 Phosphoglycerate kinase; Region: PGK; pfam00162 290399006905 substrate binding site [chemical binding]; other site 290399006906 hinge regions; other site 290399006907 ADP binding site [chemical binding]; other site 290399006908 catalytic site [active] 290399006909 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290399006910 triosephosphate isomerase; Provisional; Region: PRK14567 290399006911 substrate binding site [chemical binding]; other site 290399006912 dimer interface [polypeptide binding]; other site 290399006913 catalytic triad [active] 290399006914 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 290399006915 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 290399006916 putative active site [active] 290399006917 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290399006918 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 290399006919 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 290399006920 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 290399006921 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290399006922 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290399006923 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 290399006924 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 290399006925 active site 290399006926 dimer interface [polypeptide binding]; other site 290399006927 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290399006928 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 290399006929 putative active site [active] 290399006930 catalytic residue [active] 290399006931 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 290399006932 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290399006933 TPP-binding site [chemical binding]; other site 290399006934 dimer interface [polypeptide binding]; other site 290399006935 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290399006936 PYR/PP interface [polypeptide binding]; other site 290399006937 dimer interface [polypeptide binding]; other site 290399006938 TPP binding site [chemical binding]; other site 290399006939 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399006940 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 290399006941 UbiA prenyltransferase family; Region: UbiA; pfam01040 290399006942 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 290399006943 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 290399006944 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290399006945 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290399006946 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290399006947 Walker A/P-loop; other site 290399006948 ATP binding site [chemical binding]; other site 290399006949 Q-loop/lid; other site 290399006950 ABC transporter signature motif; other site 290399006951 Walker B; other site 290399006952 D-loop; other site 290399006953 H-loop/switch region; other site 290399006954 Predicted transcriptional regulator [Transcription]; Region: COG2345 290399006955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399006956 putative DNA binding site [nucleotide binding]; other site 290399006957 putative Zn2+ binding site [ion binding]; other site 290399006958 FeS assembly protein SufB; Region: sufB; TIGR01980 290399006959 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 290399006960 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 290399006961 FeS assembly protein SufD; Region: sufD; TIGR01981 290399006962 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 290399006963 [2Fe-2S] cluster binding site [ion binding]; other site 290399006964 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 290399006965 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 290399006966 Walker A/P-loop; other site 290399006967 ATP binding site [chemical binding]; other site 290399006968 Q-loop/lid; other site 290399006969 ABC transporter signature motif; other site 290399006970 Walker B; other site 290399006971 D-loop; other site 290399006972 H-loop/switch region; other site 290399006973 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 290399006974 Predicted metalloprotease [General function prediction only]; Region: COG2321 290399006975 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 290399006976 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 290399006977 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 290399006978 acyl-activating enzyme (AAE) consensus motif; other site 290399006979 AMP binding site [chemical binding]; other site 290399006980 active site 290399006981 CoA binding site [chemical binding]; other site 290399006982 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290399006983 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 290399006984 dimer interface [polypeptide binding]; other site 290399006985 active site 290399006986 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 290399006987 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290399006988 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399006989 Walker A/P-loop; other site 290399006990 ATP binding site [chemical binding]; other site 290399006991 Q-loop/lid; other site 290399006992 ABC transporter signature motif; other site 290399006993 Walker B; other site 290399006994 D-loop; other site 290399006995 H-loop/switch region; other site 290399006996 BioY family; Region: BioY; pfam02632 290399006997 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290399006998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399006999 Walker A/P-loop; other site 290399007000 ATP binding site [chemical binding]; other site 290399007001 Q-loop/lid; other site 290399007002 ABC transporter signature motif; other site 290399007003 Walker B; other site 290399007004 D-loop; other site 290399007005 H-loop/switch region; other site 290399007006 ABC transporter; Region: ABC_tran_2; pfam12848 290399007007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399007008 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 290399007009 putative deacylase active site [active] 290399007010 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290399007011 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 290399007012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399007013 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290399007014 NAD(P) binding site [chemical binding]; other site 290399007015 active site 290399007016 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290399007017 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290399007018 putative dimer interface [polypeptide binding]; other site 290399007019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399007020 AMP-binding enzyme; Region: AMP-binding; pfam00501 290399007021 active site 290399007022 CoA binding site [chemical binding]; other site 290399007023 AMP binding site [chemical binding]; other site 290399007024 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290399007025 short chain dehydrogenase; Provisional; Region: PRK07806 290399007026 short chain dehydrogenase; Provisional; Region: PRK12746 290399007027 NAD(P) binding site [chemical binding]; other site 290399007028 active site 290399007029 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290399007030 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290399007031 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290399007032 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290399007033 Walker A/P-loop; other site 290399007034 ATP binding site [chemical binding]; other site 290399007035 Q-loop/lid; other site 290399007036 ABC transporter signature motif; other site 290399007037 Walker B; other site 290399007038 D-loop; other site 290399007039 H-loop/switch region; other site 290399007040 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290399007041 hypothetical protein; Provisional; Region: PRK10621 290399007042 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290399007043 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290399007044 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 290399007045 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 290399007046 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290399007047 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 290399007048 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 290399007049 Zn binding site [ion binding]; other site 290399007050 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 290399007051 Uncharacterized conserved protein [Function unknown]; Region: COG2308 290399007052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 290399007053 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 290399007054 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290399007055 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 290399007056 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290399007057 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 290399007058 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290399007059 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290399007060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290399007061 Histidine kinase; Region: HisKA_3; pfam07730 290399007062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399007063 ATP binding site [chemical binding]; other site 290399007064 Mg2+ binding site [ion binding]; other site 290399007065 G-X-G motif; other site 290399007066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399007067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399007068 active site 290399007069 phosphorylation site [posttranslational modification] 290399007070 intermolecular recognition site; other site 290399007071 dimerization interface [polypeptide binding]; other site 290399007072 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399007073 DNA binding residues [nucleotide binding] 290399007074 dimerization interface [polypeptide binding]; other site 290399007075 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399007076 Ligand Binding Site [chemical binding]; other site 290399007077 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 290399007078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399007079 NAD(P) binding site [chemical binding]; other site 290399007080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399007081 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290399007082 active site 290399007083 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 290399007084 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 290399007085 ligand binding site; other site 290399007086 oligomer interface; other site 290399007087 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 290399007088 sulfate 1 binding site; other site 290399007089 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 290399007090 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290399007091 acyl-coenzyme A oxidase; Region: PLN02636 290399007092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399007093 active site 290399007094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399007095 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 290399007096 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290399007097 dimer interface [polypeptide binding]; other site 290399007098 active site 290399007099 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 290399007100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399007101 NAD(P) binding site [chemical binding]; other site 290399007102 active site 290399007103 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290399007104 active site 2 [active] 290399007105 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290399007106 Beta-lactamase; Region: Beta-lactamase; pfam00144 290399007107 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 290399007108 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 290399007109 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 290399007110 putative dimer interface [polypeptide binding]; other site 290399007111 N-terminal domain interface [polypeptide binding]; other site 290399007112 putative substrate binding pocket (H-site) [chemical binding]; other site 290399007113 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 290399007114 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 290399007115 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 290399007116 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399007117 active site 290399007118 Predicted dehydrogenase [General function prediction only]; Region: COG0579 290399007119 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290399007120 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 290399007121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399007122 S-adenosylmethionine binding site [chemical binding]; other site 290399007123 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 290399007124 hypothetical protein; Provisional; Region: PRK07906 290399007125 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 290399007126 putative metal binding site [ion binding]; other site 290399007127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290399007128 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399007129 active site 290399007130 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399007131 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399007132 active site 290399007133 catalytic tetrad [active] 290399007134 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 290399007135 cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Region: mycothiol_MshC; TIGR03447 290399007136 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399007137 active site 290399007138 HIGH motif; other site 290399007139 nucleotide binding site [chemical binding]; other site 290399007140 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399007141 active site 290399007142 KMSKS motif; other site 290399007143 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290399007144 tRNA binding surface [nucleotide binding]; other site 290399007145 anticodon binding site; other site 290399007146 PAC2 family; Region: PAC2; pfam09754 290399007147 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 290399007148 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290399007149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399007150 motif II; other site 290399007151 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 290399007152 active site 290399007153 Peptidase family M50; Region: Peptidase_M50; pfam02163 290399007154 putative substrate binding region [chemical binding]; other site 290399007155 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 290399007156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399007157 S-adenosylmethionine binding site [chemical binding]; other site 290399007158 proteasome ATPase; Region: pup_AAA; TIGR03689 290399007159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399007160 Walker A motif; other site 290399007161 ATP binding site [chemical binding]; other site 290399007162 Walker B motif; other site 290399007163 arginine finger; other site 290399007164 Pup-ligase protein; Region: Pup_ligase; cl15463 290399007165 Pup-like protein; Region: Pup; pfam05639 290399007166 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 290399007167 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 290399007168 active site 290399007169 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 290399007170 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 290399007171 active site 290399007172 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 290399007173 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 290399007174 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290399007175 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290399007176 WYL domain; Region: WYL; pfam13280 290399007177 Predicted transcriptional regulator [Transcription]; Region: COG2378 290399007178 WYL domain; Region: WYL; pfam13280 290399007179 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 290399007180 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290399007181 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 290399007182 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 290399007183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399007184 ATP binding site [chemical binding]; other site 290399007185 putative Mg++ binding site [ion binding]; other site 290399007186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399007187 nucleotide binding region [chemical binding]; other site 290399007188 ATP-binding site [chemical binding]; other site 290399007189 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 290399007190 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399007191 active site 290399007192 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 290399007193 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 290399007194 Ligand binding site; other site 290399007195 Putative Catalytic site; other site 290399007196 DXD motif; other site 290399007197 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 290399007198 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 290399007199 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290399007200 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 290399007201 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 290399007202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399007203 S-adenosylmethionine binding site [chemical binding]; other site 290399007204 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 290399007205 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290399007206 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290399007207 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290399007208 active site 290399007209 catalytic residues [active] 290399007210 metal binding site [ion binding]; metal-binding site 290399007211 SnoaL-like domain; Region: SnoaL_2; pfam12680 290399007212 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 290399007213 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399007214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399007215 S-adenosylmethionine binding site [chemical binding]; other site 290399007216 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 290399007217 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 290399007218 malonyl-CoA binding site [chemical binding]; other site 290399007219 dimer interface [polypeptide binding]; other site 290399007220 active site 290399007221 product binding site; other site 290399007222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399007223 Walker A/P-loop; other site 290399007224 ATP binding site [chemical binding]; other site 290399007225 Q-loop/lid; other site 290399007226 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290399007227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399007228 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 290399007229 Walker A/P-loop; other site 290399007230 ATP binding site [chemical binding]; other site 290399007231 Q-loop/lid; other site 290399007232 ABC transporter signature motif; other site 290399007233 Walker B; other site 290399007234 D-loop; other site 290399007235 H-loop/switch region; other site 290399007236 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 290399007237 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290399007238 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 290399007239 active site 290399007240 catalytic residues [active] 290399007241 DNA binding site [nucleotide binding] 290399007242 Int/Topo IB signature motif; other site 290399007243 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 290399007244 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290399007245 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 290399007246 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290399007247 dimer interface [polypeptide binding]; other site 290399007248 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399007249 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 290399007250 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399007251 AsnC family; Region: AsnC_trans_reg; pfam01037 290399007252 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 290399007253 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290399007254 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290399007255 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 290399007256 Subunit I/III interface [polypeptide binding]; other site 290399007257 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 290399007258 Cytochrome c; Region: Cytochrom_C; pfam00034 290399007259 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 290399007260 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 290399007261 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290399007262 iron-sulfur cluster [ion binding]; other site 290399007263 [2Fe-2S] cluster binding site [ion binding]; other site 290399007264 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 290399007265 intrachain domain interface; other site 290399007266 interchain domain interface [polypeptide binding]; other site 290399007267 heme bL binding site [chemical binding]; other site 290399007268 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 290399007269 heme bH binding site [chemical binding]; other site 290399007270 Qo binding site; other site 290399007271 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290399007272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399007273 DNA-binding site [nucleotide binding]; DNA binding site 290399007274 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290399007275 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290399007276 dimerization domain swap beta strand [polypeptide binding]; other site 290399007277 regulatory protein interface [polypeptide binding]; other site 290399007278 active site 290399007279 regulatory phosphorylation site [posttranslational modification]; other site 290399007280 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 290399007281 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 290399007282 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 290399007283 D-pathway; other site 290399007284 Putative ubiquinol binding site [chemical binding]; other site 290399007285 Low-spin heme (heme b) binding site [chemical binding]; other site 290399007286 Putative water exit pathway; other site 290399007287 Binuclear center (heme o3/CuB) [ion binding]; other site 290399007288 K-pathway; other site 290399007289 Putative proton exit pathway; other site 290399007290 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 290399007291 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 290399007292 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 290399007293 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 290399007294 hypothetical protein; Provisional; Region: PRK07907 290399007295 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 290399007296 active site 290399007297 metal binding site [ion binding]; metal-binding site 290399007298 dimer interface [polypeptide binding]; other site 290399007299 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 290399007300 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 290399007301 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 290399007302 quinone interaction residues [chemical binding]; other site 290399007303 active site 290399007304 catalytic residues [active] 290399007305 FMN binding site [chemical binding]; other site 290399007306 substrate binding site [chemical binding]; other site 290399007307 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 290399007308 PGAP1-like protein; Region: PGAP1; pfam07819 290399007309 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290399007310 monoglyceride lipase; Provisional; Region: PHA02857 290399007311 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 290399007312 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290399007313 catalytic residue [active] 290399007314 putative FPP diphosphate binding site; other site 290399007315 putative FPP binding hydrophobic cleft; other site 290399007316 dimer interface [polypeptide binding]; other site 290399007317 putative IPP diphosphate binding site; other site 290399007318 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 290399007319 Recombination protein O N terminal; Region: RecO_N; pfam11967 290399007320 Recombination protein O C terminal; Region: RecO_C; pfam02565 290399007321 2-isopropylmalate synthase; Validated; Region: PRK03739 290399007322 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 290399007323 active site 290399007324 catalytic residues [active] 290399007325 metal binding site [ion binding]; metal-binding site 290399007326 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 290399007327 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 290399007328 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 290399007329 active site 290399007330 Zn binding site [ion binding]; other site 290399007331 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 290399007332 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 290399007333 GTPase Era; Reviewed; Region: era; PRK00089 290399007334 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 290399007335 G1 box; other site 290399007336 GTP/Mg2+ binding site [chemical binding]; other site 290399007337 Switch I region; other site 290399007338 G2 box; other site 290399007339 Switch II region; other site 290399007340 G3 box; other site 290399007341 G4 box; other site 290399007342 G5 box; other site 290399007343 KH domain; Region: KH_2; pfam07650 290399007344 Domain of unknown function DUF21; Region: DUF21; pfam01595 290399007345 FOG: CBS domain [General function prediction only]; Region: COG0517 290399007346 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290399007347 Transporter associated domain; Region: CorC_HlyC; smart01091 290399007348 metal-binding heat shock protein; Provisional; Region: PRK00016 290399007349 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 290399007350 PhoH-like protein; Region: PhoH; pfam02562 290399007351 Sporulation and spore germination; Region: Germane; pfam10646 290399007352 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290399007353 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 290399007354 chaperone protein DnaJ; Provisional; Region: PRK14278 290399007355 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290399007356 HSP70 interaction site [polypeptide binding]; other site 290399007357 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290399007358 Zn binding sites [ion binding]; other site 290399007359 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290399007360 dimer interface [polypeptide binding]; other site 290399007361 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 290399007362 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 290399007363 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 290399007364 Tic20-like protein; Region: Tic20; pfam09685 290399007365 coproporphyrinogen III oxidase; Validated; Region: PRK05628 290399007366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399007367 FeS/SAM binding site; other site 290399007368 GTP-binding protein LepA; Provisional; Region: PRK05433 290399007369 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 290399007370 G1 box; other site 290399007371 putative GEF interaction site [polypeptide binding]; other site 290399007372 GTP/Mg2+ binding site [chemical binding]; other site 290399007373 Switch I region; other site 290399007374 G2 box; other site 290399007375 G3 box; other site 290399007376 Switch II region; other site 290399007377 G4 box; other site 290399007378 G5 box; other site 290399007379 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 290399007380 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 290399007381 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 290399007382 PemK-like protein; Region: PemK; pfam02452 290399007383 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 290399007384 hypothetical protein; Reviewed; Region: PRK07914 290399007385 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 290399007386 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 290399007387 Competence protein; Region: Competence; pfam03772 290399007388 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 290399007389 EDD domain protein, DegV family; Region: DegV; TIGR00762 290399007390 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 290399007391 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 290399007392 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290399007393 HIGH motif; other site 290399007394 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290399007395 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399007396 active site 290399007397 KMSKS motif; other site 290399007398 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 290399007399 tRNA binding surface [nucleotide binding]; other site 290399007400 glycerol kinase; Provisional; Region: glpK; PRK00047 290399007401 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 290399007402 N- and C-terminal domain interface [polypeptide binding]; other site 290399007403 active site 290399007404 MgATP binding site [chemical binding]; other site 290399007405 catalytic site [active] 290399007406 metal binding site [ion binding]; metal-binding site 290399007407 putative homotetramer interface [polypeptide binding]; other site 290399007408 glycerol binding site [chemical binding]; other site 290399007409 homodimer interface [polypeptide binding]; other site 290399007410 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 290399007411 amphipathic channel; other site 290399007412 Asn-Pro-Ala signature motifs; other site 290399007413 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 290399007414 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 290399007415 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 290399007416 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399007417 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399007418 active site 290399007419 catalytic tetrad [active] 290399007420 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 290399007421 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399007422 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399007423 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 290399007424 primosome assembly protein PriA; Provisional; Region: PRK14873 290399007425 S-adenosylmethionine synthetase; Validated; Region: PRK05250 290399007426 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 290399007427 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 290399007428 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 290399007429 Flavoprotein; Region: Flavoprotein; pfam02441 290399007430 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 290399007431 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 290399007432 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 290399007433 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 290399007434 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 290399007435 catalytic site [active] 290399007436 G-X2-G-X-G-K; other site 290399007437 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 290399007438 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 290399007439 active site 290399007440 dimer interface [polypeptide binding]; other site 290399007441 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 290399007442 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290399007443 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290399007444 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290399007445 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290399007446 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290399007447 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 290399007448 IMP binding site; other site 290399007449 dimer interface [polypeptide binding]; other site 290399007450 interdomain contacts; other site 290399007451 partial ornithine binding site; other site 290399007452 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 290399007453 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 290399007454 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 290399007455 catalytic site [active] 290399007456 subunit interface [polypeptide binding]; other site 290399007457 dihydroorotase; Validated; Region: pyrC; PRK09357 290399007458 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 290399007459 active site 290399007460 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 290399007461 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290399007462 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290399007463 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 290399007464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399007465 active site 290399007466 Protease prsW family; Region: PrsW-protease; pfam13367 290399007467 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 290399007468 putative RNA binding site [nucleotide binding]; other site 290399007469 elongation factor P; Validated; Region: PRK00529 290399007470 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290399007471 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290399007472 RNA binding site [nucleotide binding]; other site 290399007473 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290399007474 RNA binding site [nucleotide binding]; other site 290399007475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290399007476 TPR motif; other site 290399007477 binding surface 290399007478 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290399007479 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 290399007480 active site 290399007481 dimer interface [polypeptide binding]; other site 290399007482 metal binding site [ion binding]; metal-binding site 290399007483 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290399007484 Shikimate kinase; Region: SKI; pfam01202 290399007485 ADP binding site [chemical binding]; other site 290399007486 magnesium binding site [ion binding]; other site 290399007487 putative shikimate binding site; other site 290399007488 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 290399007489 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 290399007490 Tetramer interface [polypeptide binding]; other site 290399007491 active site 290399007492 FMN-binding site [chemical binding]; other site 290399007493 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 290399007494 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290399007495 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290399007496 shikimate binding site; other site 290399007497 NAD(P) binding site [chemical binding]; other site 290399007498 YceG-like family; Region: YceG; pfam02618 290399007499 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 290399007500 dimerization interface [polypeptide binding]; other site 290399007501 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 290399007502 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 290399007503 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 290399007504 motif 1; other site 290399007505 active site 290399007506 motif 2; other site 290399007507 motif 3; other site 290399007508 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 290399007509 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 290399007510 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 290399007511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290399007512 RNA binding surface [nucleotide binding]; other site 290399007513 recombination factor protein RarA; Reviewed; Region: PRK13342 290399007514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399007515 Walker A motif; other site 290399007516 ATP binding site [chemical binding]; other site 290399007517 Walker B motif; other site 290399007518 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 290399007519 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 290399007520 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399007521 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399007522 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399007523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399007524 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 290399007525 NAD(P) binding site [chemical binding]; other site 290399007526 active site 290399007527 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 290399007528 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 290399007529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399007530 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399007531 putative substrate translocation pore; other site 290399007532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399007533 Coenzyme A binding pocket [chemical binding]; other site 290399007534 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 290399007535 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 290399007536 dimer interface [polypeptide binding]; other site 290399007537 anticodon binding site; other site 290399007538 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 290399007539 homodimer interface [polypeptide binding]; other site 290399007540 motif 1; other site 290399007541 active site 290399007542 motif 2; other site 290399007543 GAD domain; Region: GAD; pfam02938 290399007544 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290399007545 active site 290399007546 motif 3; other site 290399007547 amino acid transporter; Region: 2A0306; TIGR00909 290399007548 histidyl-tRNA synthetase; Region: hisS; TIGR00442 290399007549 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 290399007550 dimer interface [polypeptide binding]; other site 290399007551 motif 1; other site 290399007552 active site 290399007553 motif 2; other site 290399007554 motif 3; other site 290399007555 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 290399007556 anticodon binding site; other site 290399007557 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 290399007558 active site 290399007559 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290399007560 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 290399007561 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 290399007562 HD domain; Region: HD_4; pfam13328 290399007563 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290399007564 synthetase active site [active] 290399007565 NTP binding site [chemical binding]; other site 290399007566 metal binding site [ion binding]; metal-binding site 290399007567 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290399007568 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290399007569 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 290399007570 Protein export membrane protein; Region: SecD_SecF; cl14618 290399007571 protein-export membrane protein SecD; Region: secD; TIGR01129 290399007572 Protein export membrane protein; Region: SecD_SecF; cl14618 290399007573 Preprotein translocase subunit; Region: YajC; pfam02699 290399007574 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 290399007575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399007576 Walker A motif; other site 290399007577 ATP binding site [chemical binding]; other site 290399007578 Walker B motif; other site 290399007579 arginine finger; other site 290399007580 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 290399007581 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 290399007582 RuvA N terminal domain; Region: RuvA_N; pfam01330 290399007583 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 290399007584 active site 290399007585 putative DNA-binding cleft [nucleotide binding]; other site 290399007586 dimer interface [polypeptide binding]; other site 290399007587 hypothetical protein; Validated; Region: PRK00110 290399007588 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 290399007589 predicted active site [active] 290399007590 catalytic triad [active] 290399007591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290399007592 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 290399007593 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 290399007594 catalytic triad [active] 290399007595 NUDIX domain; Region: NUDIX; pfam00293 290399007596 nudix motif; other site 290399007597 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290399007598 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290399007599 protein binding site [polypeptide binding]; other site 290399007600 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 290399007601 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 290399007602 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 290399007603 putative active site [active] 290399007604 putative metal binding site [ion binding]; other site 290399007605 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 290399007606 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 290399007607 active site 290399007608 Zn binding site [ion binding]; other site 290399007609 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 290399007610 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 290399007611 active site 290399007612 multimer interface [polypeptide binding]; other site 290399007613 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 290399007614 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 290399007615 nucleotide binding site/active site [active] 290399007616 HIT family signature motif; other site 290399007617 catalytic residue [active] 290399007618 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 290399007619 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 290399007620 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 290399007621 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290399007622 active site 290399007623 dimer interface [polypeptide binding]; other site 290399007624 motif 1; other site 290399007625 motif 2; other site 290399007626 motif 3; other site 290399007627 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290399007628 anticodon binding site; other site 290399007629 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 290399007630 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 290399007631 active site 290399007632 PHP Thumb interface [polypeptide binding]; other site 290399007633 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290399007634 generic binding surface II; other site 290399007635 generic binding surface I; other site 290399007636 Chorismate mutase type II; Region: CM_2; smart00830 290399007637 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399007638 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 290399007639 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 290399007640 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290399007641 catalytic residues [active] 290399007642 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290399007643 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 290399007644 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 290399007645 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290399007646 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290399007647 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290399007648 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290399007649 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 290399007650 recombination protein F; Reviewed; Region: recF; PRK00064 290399007651 Cupin domain; Region: Cupin_2; cl17218 290399007652 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 290399007653 NlpC/P60 family; Region: NLPC_P60; cl17555 290399007654 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 290399007655 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 290399007656 putative active site [active] 290399007657 putative metal binding site [ion binding]; other site 290399007658 S-layer homology domain; Region: SLH; pfam00395 290399007659 S-layer homology domain; Region: SLH; pfam00395 290399007660 S-layer homology domain; Region: SLH; pfam00395 290399007661 A new structural DNA glycosylase; Region: AlkD_like; cl11434 290399007662 active site 290399007663 ribonuclease Z; Reviewed; Region: PRK00055 290399007664 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290399007665 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399007666 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290399007667 Walker A/P-loop; other site 290399007668 ATP binding site [chemical binding]; other site 290399007669 Q-loop/lid; other site 290399007670 ABC transporter signature motif; other site 290399007671 Walker B; other site 290399007672 D-loop; other site 290399007673 H-loop/switch region; other site 290399007674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399007675 dimer interface [polypeptide binding]; other site 290399007676 conserved gate region; other site 290399007677 putative PBP binding loops; other site 290399007678 ABC-ATPase subunit interface; other site 290399007679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399007680 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290399007681 substrate binding pocket [chemical binding]; other site 290399007682 membrane-bound complex binding site; other site 290399007683 hinge residues; other site 290399007684 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 290399007685 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 290399007686 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 290399007687 OsmC-like protein; Region: OsmC; pfam02566 290399007688 SnoaL-like domain; Region: SnoaL_3; pfam13474 290399007689 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 290399007690 classical (c) SDRs; Region: SDR_c; cd05233 290399007691 NAD(P) binding site [chemical binding]; other site 290399007692 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399007693 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399007694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399007695 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 290399007696 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 290399007697 dimer interface [polypeptide binding]; other site 290399007698 putative radical transfer pathway; other site 290399007699 diiron center [ion binding]; other site 290399007700 tyrosyl radical; other site 290399007701 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 290399007702 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 290399007703 Class I ribonucleotide reductase; Region: RNR_I; cd01679 290399007704 active site 290399007705 dimer interface [polypeptide binding]; other site 290399007706 catalytic residues [active] 290399007707 effector binding site; other site 290399007708 R2 peptide binding site; other site 290399007709 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 290399007710 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 290399007711 catalytic residues [active] 290399007712 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 290399007713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399007714 S-adenosylmethionine binding site [chemical binding]; other site 290399007715 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 290399007716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399007717 S-adenosylmethionine binding site [chemical binding]; other site 290399007718 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 290399007719 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 290399007720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399007721 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290399007722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399007723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399007724 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290399007725 dimerization interface [polypeptide binding]; other site 290399007726 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 290399007727 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 290399007728 NAD(P) binding site [chemical binding]; other site 290399007729 catalytic residues [active] 290399007730 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 290399007731 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 290399007732 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 290399007733 THF binding site; other site 290399007734 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 290399007735 substrate binding site [chemical binding]; other site 290399007736 THF binding site; other site 290399007737 zinc-binding site [ion binding]; other site 290399007738 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 290399007739 FAD binding site [chemical binding]; other site 290399007740 von Willebrand factor type A domain; Region: VWA_2; pfam13519 290399007741 metal ion-dependent adhesion site (MIDAS); other site 290399007742 von Willebrand factor type A domain; Region: VWA_2; pfam13519 290399007743 metal ion-dependent adhesion site (MIDAS); other site 290399007744 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290399007745 Protein of unknown function DUF58; Region: DUF58; pfam01882 290399007746 MoxR-like ATPases [General function prediction only]; Region: COG0714 290399007747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399007748 Walker A motif; other site 290399007749 ATP binding site [chemical binding]; other site 290399007750 Walker B motif; other site 290399007751 arginine finger; other site 290399007752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399007753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399007754 dimer interface [polypeptide binding]; other site 290399007755 conserved gate region; other site 290399007756 putative PBP binding loops; other site 290399007757 ABC-ATPase subunit interface; other site 290399007758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399007759 dimer interface [polypeptide binding]; other site 290399007760 conserved gate region; other site 290399007761 putative PBP binding loops; other site 290399007762 ABC-ATPase subunit interface; other site 290399007763 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399007764 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290399007765 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290399007766 non-specific DNA interactions [nucleotide binding]; other site 290399007767 DNA binding site [nucleotide binding] 290399007768 sequence specific DNA binding site [nucleotide binding]; other site 290399007769 putative cAMP binding site [chemical binding]; other site 290399007770 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399007771 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290399007772 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 290399007773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399007774 S-adenosylmethionine binding site [chemical binding]; other site 290399007775 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 290399007776 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399007777 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 290399007778 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 290399007779 PhnA protein; Region: PhnA; pfam03831 290399007780 Oligomerisation domain; Region: Oligomerisation; pfam02410 290399007781 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 290399007782 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 290399007783 active site 290399007784 (T/H)XGH motif; other site 290399007785 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 290399007786 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 290399007787 putative catalytic cysteine [active] 290399007788 gamma-glutamyl kinase; Provisional; Region: PRK05429 290399007789 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 290399007790 nucleotide binding site [chemical binding]; other site 290399007791 homotetrameric interface [polypeptide binding]; other site 290399007792 putative phosphate binding site [ion binding]; other site 290399007793 putative allosteric binding site; other site 290399007794 PUA domain; Region: PUA; pfam01472 290399007795 GTPase CgtA; Reviewed; Region: obgE; PRK12296 290399007796 GTP1/OBG; Region: GTP1_OBG; pfam01018 290399007797 Obg GTPase; Region: Obg; cd01898 290399007798 G1 box; other site 290399007799 GTP/Mg2+ binding site [chemical binding]; other site 290399007800 Switch I region; other site 290399007801 G2 box; other site 290399007802 G3 box; other site 290399007803 Switch II region; other site 290399007804 G4 box; other site 290399007805 G5 box; other site 290399007806 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 290399007807 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 290399007808 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 290399007809 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 290399007810 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290399007811 dimer interface [polypeptide binding]; other site 290399007812 substrate binding site [chemical binding]; other site 290399007813 ATP binding site [chemical binding]; other site 290399007814 Putative transcription activator [Transcription]; Region: TenA; COG0819 290399007815 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 290399007816 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290399007817 homodimer interface [polypeptide binding]; other site 290399007818 oligonucleotide binding site [chemical binding]; other site 290399007819 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 290399007820 putative active site [active] 290399007821 redox center [active] 290399007822 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 290399007823 active site 290399007824 multimer interface [polypeptide binding]; other site 290399007825 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 290399007826 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 290399007827 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290399007828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290399007829 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 290399007830 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290399007831 HIGH motif; other site 290399007832 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 290399007833 active site 290399007834 KMSKS motif; other site 290399007835 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 290399007836 tRNA binding surface [nucleotide binding]; other site 290399007837 anticodon binding site; other site 290399007838 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 290399007839 putative catalytic site [active] 290399007840 putative metal binding site [ion binding]; other site 290399007841 putative phosphate binding site [ion binding]; other site 290399007842 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290399007843 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290399007844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399007845 NAD(P) binding site [chemical binding]; other site 290399007846 active site 290399007847 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 290399007848 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399007849 active site 290399007850 HIGH motif; other site 290399007851 nucleotide binding site [chemical binding]; other site 290399007852 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399007853 active site 290399007854 KMSKS motif; other site 290399007855 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290399007856 tRNA binding surface [nucleotide binding]; other site 290399007857 anticodon binding site; other site 290399007858 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 290399007859 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290399007860 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 290399007861 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 290399007862 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 290399007863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399007864 Walker A motif; other site 290399007865 ATP binding site [chemical binding]; other site 290399007866 Walker B motif; other site 290399007867 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290399007868 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 290399007869 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290399007870 oligomer interface [polypeptide binding]; other site 290399007871 active site residues [active] 290399007872 Clp protease; Region: CLP_protease; pfam00574 290399007873 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290399007874 oligomer interface [polypeptide binding]; other site 290399007875 active site residues [active] 290399007876 trigger factor; Provisional; Region: tig; PRK01490 290399007877 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290399007878 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 290399007879 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 290399007880 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 290399007881 putative DNA binding site [nucleotide binding]; other site 290399007882 catalytic residue [active] 290399007883 putative H2TH interface [polypeptide binding]; other site 290399007884 putative catalytic residues [active] 290399007885 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290399007886 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 290399007887 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 290399007888 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 290399007889 Zn binding site [ion binding]; other site 290399007890 OsmC-like protein; Region: OsmC; cl00767 290399007891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399007892 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 290399007893 NAD(P) binding site [chemical binding]; other site 290399007894 active site 290399007895 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290399007896 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290399007897 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 290399007898 apolar tunnel; other site 290399007899 heme binding site [chemical binding]; other site 290399007900 dimerization interface [polypeptide binding]; other site 290399007901 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 290399007902 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 290399007903 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 290399007904 active site 290399007905 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 290399007906 catalytic triad [active] 290399007907 dimer interface [polypeptide binding]; other site 290399007908 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 290399007909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399007910 Walker A/P-loop; other site 290399007911 ATP binding site [chemical binding]; other site 290399007912 Q-loop/lid; other site 290399007913 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399007914 ABC transporter signature motif; other site 290399007915 Walker B; other site 290399007916 D-loop; other site 290399007917 ABC transporter; Region: ABC_tran_2; pfam12848 290399007918 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399007919 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290399007920 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290399007921 dimer interface [polypeptide binding]; other site 290399007922 ssDNA binding site [nucleotide binding]; other site 290399007923 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290399007924 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 290399007925 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290399007926 putative hydrophobic ligand binding site [chemical binding]; other site 290399007927 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399007928 Protein of unknown function (DUF993); Region: DUF993; pfam06187 290399007929 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399007930 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399007931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399007932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399007933 DNA binding site [nucleotide binding] 290399007934 domain linker motif; other site 290399007935 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399007936 dimerization interface [polypeptide binding]; other site 290399007937 ligand binding site [chemical binding]; other site 290399007938 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 290399007939 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290399007940 MarR family; Region: MarR_2; pfam12802 290399007941 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399007942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290399007943 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 290399007944 xylose isomerase; Provisional; Region: PRK12677 290399007945 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 290399007946 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290399007947 nucleotide binding site [chemical binding]; other site 290399007948 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 290399007949 active site 290399007950 catalytic residues [active] 290399007951 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 290399007952 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 290399007953 active site 290399007954 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 290399007955 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 290399007956 catalytic site [active] 290399007957 putative active site [active] 290399007958 putative substrate binding site [chemical binding]; other site 290399007959 dimer interface [polypeptide binding]; other site 290399007960 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290399007961 active site 290399007962 catalytic residues [active] 290399007963 metal binding site [ion binding]; metal-binding site 290399007964 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 290399007965 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 290399007966 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 290399007967 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290399007968 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 290399007969 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290399007970 Putative esterase; Region: Esterase; pfam00756 290399007971 S-formylglutathione hydrolase; Region: PLN02442 290399007972 hypothetical protein; Validated; Region: PRK02101 290399007973 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 290399007974 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 290399007975 Putative zinc ribbon domain; Region: DUF164; pfam02591 290399007976 Uncharacterized conserved protein [Function unknown]; Region: COG0327 290399007977 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 290399007978 methionine sulfoxide reductase A; Provisional; Region: PRK14054 290399007979 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290399007980 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290399007981 dimer interface [polypeptide binding]; other site 290399007982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399007983 catalytic residue [active] 290399007984 serine O-acetyltransferase; Region: cysE; TIGR01172 290399007985 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290399007986 trimer interface [polypeptide binding]; other site 290399007987 active site 290399007988 substrate binding site [chemical binding]; other site 290399007989 CoA binding site [chemical binding]; other site 290399007990 short chain dehydrogenase; Validated; Region: PRK06182 290399007991 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 290399007992 NADP binding site [chemical binding]; other site 290399007993 active site 290399007994 steroid binding site; other site 290399007995 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399007996 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 290399007997 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 290399007998 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399007999 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 290399008000 DNA-binding site [nucleotide binding]; DNA binding site 290399008001 FCD domain; Region: FCD; pfam07729 290399008002 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 290399008003 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399008004 putative NAD(P) binding site [chemical binding]; other site 290399008005 catalytic Zn binding site [ion binding]; other site 290399008006 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 290399008007 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 290399008008 NADP binding site [chemical binding]; other site 290399008009 homodimer interface [polypeptide binding]; other site 290399008010 active site 290399008011 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290399008012 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399008013 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399008014 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 290399008015 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290399008016 NAD binding site [chemical binding]; other site 290399008017 ligand binding site [chemical binding]; other site 290399008018 catalytic site [active] 290399008019 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 290399008020 EamA-like transporter family; Region: EamA; pfam00892 290399008021 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 290399008022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399008023 DNA-binding site [nucleotide binding]; DNA binding site 290399008024 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399008025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399008026 homodimer interface [polypeptide binding]; other site 290399008027 catalytic residue [active] 290399008028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399008029 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399008030 putative substrate translocation pore; other site 290399008031 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399008032 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399008033 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399008034 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 290399008035 NAD-dependent deacetylase; Provisional; Region: PRK00481 290399008036 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 290399008037 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290399008038 dimer interface [polypeptide binding]; other site 290399008039 catalytic triad [active] 290399008040 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 290399008041 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290399008042 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290399008043 dimer interface [polypeptide binding]; other site 290399008044 TPP-binding site [chemical binding]; other site 290399008045 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399008046 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 290399008047 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290399008048 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 290399008049 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290399008050 dimer interface [polypeptide binding]; other site 290399008051 active site 290399008052 CoA binding pocket [chemical binding]; other site 290399008053 acyl carrier protein; Provisional; Region: acpP; PRK00982 290399008054 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 290399008055 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290399008056 dimer interface [polypeptide binding]; other site 290399008057 active site 290399008058 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 290399008059 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290399008060 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290399008061 active site 290399008062 DNA binding site [nucleotide binding] 290399008063 Int/Topo IB signature motif; other site 290399008064 DNA protecting protein DprA; Region: dprA; TIGR00732 290399008065 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 290399008066 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 290399008067 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290399008068 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 290399008069 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 290399008070 hypothetical protein; Reviewed; Region: PRK12497 290399008071 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 290399008072 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 290399008073 RNA/DNA hybrid binding site [nucleotide binding]; other site 290399008074 active site 290399008075 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 290399008076 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290399008077 Catalytic site [active] 290399008078 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 290399008079 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290399008080 Catalytic site [active] 290399008081 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 290399008082 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 290399008083 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 290399008084 RimM N-terminal domain; Region: RimM; pfam01782 290399008085 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 290399008086 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 290399008087 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 290399008088 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 290399008089 putative metal binding site [ion binding]; other site 290399008090 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399008091 active site 290399008092 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 290399008093 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399008094 active site 290399008095 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290399008096 ThiC-associated domain; Region: ThiC-associated; pfam13667 290399008097 ThiC family; Region: ThiC; pfam01964 290399008098 signal recognition particle protein; Provisional; Region: PRK10867 290399008099 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 290399008100 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290399008101 P loop; other site 290399008102 GTP binding site [chemical binding]; other site 290399008103 Signal peptide binding domain; Region: SRP_SPB; pfam02978 290399008104 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 290399008105 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290399008106 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290399008107 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 290399008108 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290399008109 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 290399008110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399008111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399008112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399008113 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 290399008114 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 290399008115 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399008116 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 290399008117 AAA domain; Region: AAA_23; pfam13476 290399008118 Walker A/P-loop; other site 290399008119 ATP binding site [chemical binding]; other site 290399008120 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 290399008121 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 290399008122 ABC transporter signature motif; other site 290399008123 Walker B; other site 290399008124 D-loop; other site 290399008125 H-loop/switch region; other site 290399008126 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290399008127 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290399008128 Bacterial Ig-like domain; Region: Big_5; pfam13205 290399008129 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290399008130 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290399008131 Bacterial Ig-like domain; Region: Big_5; pfam13205 290399008132 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 290399008133 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 290399008134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399008135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399008136 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 290399008137 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 290399008138 DNA binding site [nucleotide binding] 290399008139 catalytic residue [active] 290399008140 H2TH interface [polypeptide binding]; other site 290399008141 putative catalytic residues [active] 290399008142 turnover-facilitating residue; other site 290399008143 intercalation triad [nucleotide binding]; other site 290399008144 8OG recognition residue [nucleotide binding]; other site 290399008145 putative reading head residues; other site 290399008146 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 290399008147 ribonuclease III; Reviewed; Region: rnc; PRK00102 290399008148 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 290399008149 dimerization interface [polypeptide binding]; other site 290399008150 active site 290399008151 metal binding site [ion binding]; metal-binding site 290399008152 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 290399008153 dsRNA binding site [nucleotide binding]; other site 290399008154 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 290399008155 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 290399008156 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 290399008157 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 290399008158 active site 290399008159 (T/H)XGH motif; other site 290399008160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399008161 NAD(P) binding site [chemical binding]; other site 290399008162 active site 290399008163 aminotransferase; Validated; Region: PRK07777 290399008164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399008165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399008166 homodimer interface [polypeptide binding]; other site 290399008167 catalytic residue [active] 290399008168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290399008169 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 290399008170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399008171 S-adenosylmethionine binding site [chemical binding]; other site 290399008172 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 290399008173 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 290399008174 generic binding surface II; other site 290399008175 ssDNA binding site; other site 290399008176 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399008177 ATP binding site [chemical binding]; other site 290399008178 putative Mg++ binding site [ion binding]; other site 290399008179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399008180 nucleotide binding region [chemical binding]; other site 290399008181 ATP-binding site [chemical binding]; other site 290399008182 DAK2 domain; Region: Dak2; pfam02734 290399008183 thiamine monophosphate kinase; Provisional; Region: PRK05731 290399008184 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 290399008185 ATP binding site [chemical binding]; other site 290399008186 dimerization interface [polypeptide binding]; other site 290399008187 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 290399008188 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 290399008189 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290399008190 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290399008191 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 290399008192 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290399008193 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 290399008194 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290399008195 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290399008196 putative acyl-acceptor binding pocket; other site 290399008197 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290399008198 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 290399008199 hinge; other site 290399008200 active site 290399008201 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 290399008202 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 290399008203 substrate binding site [chemical binding]; other site 290399008204 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 290399008205 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 290399008206 substrate binding site [chemical binding]; other site 290399008207 ligand binding site [chemical binding]; other site 290399008208 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399008209 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399008210 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399008211 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 290399008212 YfjP GTPase; Region: YfjP; cd11383 290399008213 G1 box; other site 290399008214 GTP/Mg2+ binding site [chemical binding]; other site 290399008215 Switch I region; other site 290399008216 G2 box; other site 290399008217 Switch II region; other site 290399008218 G3 box; other site 290399008219 G4 box; other site 290399008220 Protein of unknown function, DUF258; Region: DUF258; pfam03193 290399008221 Dynamin family; Region: Dynamin_N; pfam00350 290399008222 Predicted membrane protein [Function unknown]; Region: COG1511 290399008223 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 290399008224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399008225 motif II; other site 290399008226 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 290399008227 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290399008228 HIGH motif; other site 290399008229 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290399008230 active site 290399008231 KMSKS motif; other site 290399008232 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 290399008233 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290399008234 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290399008235 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290399008236 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 290399008237 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 290399008238 homodimer interface [polypeptide binding]; other site 290399008239 substrate-cofactor binding pocket; other site 290399008240 catalytic residue [active] 290399008241 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 290399008242 tartrate dehydrogenase; Region: TTC; TIGR02089 290399008243 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 290399008244 active site 290399008245 catalytic site [active] 290399008246 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 290399008247 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 290399008248 active site 290399008249 HIGH motif; other site 290399008250 KMSKS motif; other site 290399008251 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 290399008252 tRNA binding surface [nucleotide binding]; other site 290399008253 anticodon binding site; other site 290399008254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290399008255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290399008256 Walker A/P-loop; other site 290399008257 ATP binding site [chemical binding]; other site 290399008258 Q-loop/lid; other site 290399008259 ABC transporter signature motif; other site 290399008260 Walker B; other site 290399008261 D-loop; other site 290399008262 H-loop/switch region; other site 290399008263 FtsX-like permease family; Region: FtsX; pfam02687 290399008264 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 290399008265 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 290399008266 ligand binding site [chemical binding]; other site 290399008267 NAD binding site [chemical binding]; other site 290399008268 dimerization interface [polypeptide binding]; other site 290399008269 catalytic site [active] 290399008270 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 290399008271 putative L-serine binding site [chemical binding]; other site 290399008272 ketol-acid reductoisomerase; Provisional; Region: PRK05479 290399008273 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 290399008274 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290399008275 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 290399008276 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290399008277 putative valine binding site [chemical binding]; other site 290399008278 dimer interface [polypeptide binding]; other site 290399008279 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 290399008280 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 290399008281 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290399008282 PYR/PP interface [polypeptide binding]; other site 290399008283 dimer interface [polypeptide binding]; other site 290399008284 TPP binding site [chemical binding]; other site 290399008285 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399008286 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290399008287 TPP-binding site [chemical binding]; other site 290399008288 dimer interface [polypeptide binding]; other site 290399008289 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 290399008290 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399008291 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399008292 putative DNA binding site [nucleotide binding]; other site 290399008293 putative Zn2+ binding site [ion binding]; other site 290399008294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290399008295 dimerization interface [polypeptide binding]; other site 290399008296 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 290399008297 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 290399008298 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 290399008299 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399008300 MarR family; Region: MarR_2; cl17246 290399008301 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290399008302 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290399008303 catalytic triad [active] 290399008304 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 290399008305 Fasciclin domain; Region: Fasciclin; pfam02469 290399008306 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 290399008307 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290399008308 peptide binding site [polypeptide binding]; other site 290399008309 malate:quinone oxidoreductase; Validated; Region: PRK05257 290399008310 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 290399008311 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290399008312 Protein export membrane protein; Region: SecD_SecF; cl14618 290399008313 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 290399008314 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290399008315 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 290399008316 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399008317 MarR family; Region: MarR_2; cl17246 290399008318 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290399008319 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290399008320 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 290399008321 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290399008322 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290399008323 Predicted membrane protein [Function unknown]; Region: COG2246 290399008324 GtrA-like protein; Region: GtrA; pfam04138 290399008325 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 290399008326 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 290399008327 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399008328 catalytic residue [active] 290399008329 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 290399008330 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 290399008331 dimerization interface [polypeptide binding]; other site 290399008332 active site 290399008333 FAD binding domain; Region: FAD_binding_2; pfam00890 290399008334 L-aspartate oxidase; Provisional; Region: PRK06175 290399008335 quinolinate synthetase; Provisional; Region: PRK09375 290399008336 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 290399008337 nudix motif; other site 290399008338 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 290399008339 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399008340 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290399008341 AsnC family; Region: AsnC_trans_reg; pfam01037 290399008342 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290399008343 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290399008344 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290399008345 tetramer interface [polypeptide binding]; other site 290399008346 TPP-binding site [chemical binding]; other site 290399008347 heterodimer interface [polypeptide binding]; other site 290399008348 phosphorylation loop region [posttranslational modification] 290399008349 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290399008350 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290399008351 alpha subunit interface [polypeptide binding]; other site 290399008352 TPP binding site [chemical binding]; other site 290399008353 heterodimer interface [polypeptide binding]; other site 290399008354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399008355 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290399008356 E3 interaction surface; other site 290399008357 lipoyl attachment site [posttranslational modification]; other site 290399008358 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290399008359 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399008360 catalytic site [active] 290399008361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399008362 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399008363 putative substrate translocation pore; other site 290399008364 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 290399008365 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399008366 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 290399008367 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 290399008368 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399008369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399008370 putative DNA binding site [nucleotide binding]; other site 290399008371 dimerization interface [polypeptide binding]; other site 290399008372 putative Zn2+ binding site [ion binding]; other site 290399008373 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399008374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399008375 AAA domain; Region: AAA_23; pfam13476 290399008376 Walker A/P-loop; other site 290399008377 ATP binding site [chemical binding]; other site 290399008378 Q-loop/lid; other site 290399008379 ABC transporter signature motif; other site 290399008380 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 290399008381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399008382 ABC transporter signature motif; other site 290399008383 Walker B; other site 290399008384 D-loop; other site 290399008385 H-loop/switch region; other site 290399008386 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 290399008387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290399008388 active site 290399008389 metal binding site [ion binding]; metal-binding site 290399008390 DNA binding site [nucleotide binding] 290399008391 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 290399008392 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 290399008393 amphipathic channel; other site 290399008394 Asn-Pro-Ala signature motifs; other site 290399008395 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 290399008396 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 290399008397 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 290399008398 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 290399008399 active site 290399008400 catalytic site [active] 290399008401 substrate binding site [chemical binding]; other site 290399008402 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290399008403 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290399008404 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 290399008405 active site 290399008406 dimerization interface [polypeptide binding]; other site 290399008407 ribonuclease PH; Reviewed; Region: rph; PRK00173 290399008408 Ribonuclease PH; Region: RNase_PH_bact; cd11362 290399008409 hexamer interface [polypeptide binding]; other site 290399008410 active site 290399008411 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 290399008412 glutamate racemase; Provisional; Region: PRK00865 290399008413 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 290399008414 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 290399008415 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 290399008416 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 290399008417 active site 290399008418 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 290399008419 Isochorismatase family; Region: Isochorismatase; pfam00857 290399008420 catalytic triad [active] 290399008421 metal binding site [ion binding]; metal-binding site 290399008422 conserved cis-peptide bond; other site 290399008423 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 290399008424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399008425 ATP binding site [chemical binding]; other site 290399008426 putative Mg++ binding site [ion binding]; other site 290399008427 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 290399008428 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 290399008429 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290399008430 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 290399008431 active site 290399008432 trimer interface [polypeptide binding]; other site 290399008433 allosteric site; other site 290399008434 active site lid [active] 290399008435 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290399008436 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 290399008437 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290399008438 Walker A/P-loop; other site 290399008439 ATP binding site [chemical binding]; other site 290399008440 Q-loop/lid; other site 290399008441 ABC transporter signature motif; other site 290399008442 Walker B; other site 290399008443 D-loop; other site 290399008444 H-loop/switch region; other site 290399008445 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290399008446 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 290399008447 active site 290399008448 FMN binding site [chemical binding]; other site 290399008449 substrate binding site [chemical binding]; other site 290399008450 homotetramer interface [polypeptide binding]; other site 290399008451 catalytic residue [active] 290399008452 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 290399008453 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 290399008454 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290399008455 Domain of unknown function DUF20; Region: UPF0118; pfam01594 290399008456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399008457 hypothetical protein; Provisional; Region: PRK03298 290399008458 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290399008459 DNA-binding site [nucleotide binding]; DNA binding site 290399008460 RNA-binding motif; other site 290399008461 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 290399008462 Putative esterase; Region: Esterase; pfam00756 290399008463 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 290399008464 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 290399008465 gamma subunit interface [polypeptide binding]; other site 290399008466 epsilon subunit interface [polypeptide binding]; other site 290399008467 LBP interface [polypeptide binding]; other site 290399008468 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 290399008469 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290399008470 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 290399008471 alpha subunit interaction interface [polypeptide binding]; other site 290399008472 Walker A motif; other site 290399008473 ATP binding site [chemical binding]; other site 290399008474 Walker B motif; other site 290399008475 inhibitor binding site; inhibition site 290399008476 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290399008477 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 290399008478 core domain interface [polypeptide binding]; other site 290399008479 delta subunit interface [polypeptide binding]; other site 290399008480 epsilon subunit interface [polypeptide binding]; other site 290399008481 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 290399008482 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290399008483 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 290399008484 beta subunit interaction interface [polypeptide binding]; other site 290399008485 Walker A motif; other site 290399008486 ATP binding site [chemical binding]; other site 290399008487 Walker B motif; other site 290399008488 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290399008489 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 290399008490 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 290399008491 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 290399008492 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 290399008493 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 290399008494 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 290399008495 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 290399008496 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 290399008497 Mg++ binding site [ion binding]; other site 290399008498 putative catalytic motif [active] 290399008499 substrate binding site [chemical binding]; other site 290399008500 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290399008501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399008502 active site 290399008503 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 290399008504 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290399008505 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 290399008506 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290399008507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399008508 S-adenosylmethionine binding site [chemical binding]; other site 290399008509 peptide chain release factor 1; Validated; Region: prfA; PRK00591 290399008510 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290399008511 RF-1 domain; Region: RF-1; pfam00472 290399008512 transcription termination factor Rho; Provisional; Region: PRK12608 290399008513 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 290399008514 RNA binding site [nucleotide binding]; other site 290399008515 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 290399008516 multimer interface [polypeptide binding]; other site 290399008517 Walker A motif; other site 290399008518 ATP binding site [chemical binding]; other site 290399008519 Walker B motif; other site 290399008520 homoserine kinase; Provisional; Region: PRK01212 290399008521 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290399008522 threonine synthase; Reviewed; Region: PRK06721 290399008523 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 290399008524 homodimer interface [polypeptide binding]; other site 290399008525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399008526 catalytic residue [active] 290399008527 homoserine dehydrogenase; Provisional; Region: PRK06349 290399008528 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290399008529 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290399008530 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 290399008531 diaminopimelate decarboxylase; Region: lysA; TIGR01048 290399008532 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 290399008533 active site 290399008534 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290399008535 substrate binding site [chemical binding]; other site 290399008536 catalytic residues [active] 290399008537 dimer interface [polypeptide binding]; other site 290399008538 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 290399008539 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 290399008540 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290399008541 active site 290399008542 HIGH motif; other site 290399008543 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290399008544 KMSK motif region; other site 290399008545 tRNA binding surface [nucleotide binding]; other site 290399008546 DALR anticodon binding domain; Region: DALR_1; smart00836 290399008547 anticodon binding site; other site 290399008548 FMN-binding domain; Region: FMN_bind; cl01081 290399008549 ApbE family; Region: ApbE; pfam02424 290399008550 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 290399008551 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 290399008552 FAD binding pocket [chemical binding]; other site 290399008553 conserved FAD binding motif [chemical binding]; other site 290399008554 phosphate binding motif [ion binding]; other site 290399008555 beta-alpha-beta structure motif; other site 290399008556 NAD binding pocket [chemical binding]; other site 290399008557 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 290399008558 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 290399008559 active site 290399008560 Zn binding site [ion binding]; other site 290399008561 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 290399008562 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 290399008563 conserved cys residue [active] 290399008564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399008565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399008566 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 290399008567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399008568 ATP binding site [chemical binding]; other site 290399008569 putative Mg++ binding site [ion binding]; other site 290399008570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399008571 nucleotide binding region [chemical binding]; other site 290399008572 ATP-binding site [chemical binding]; other site 290399008573 Helicase associated domain (HA2); Region: HA2; pfam04408 290399008574 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 290399008575 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 290399008576 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 290399008577 nucleotide binding site/active site [active] 290399008578 HIT family signature motif; other site 290399008579 catalytic residue [active] 290399008580 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 290399008581 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290399008582 putative NAD(P) binding site [chemical binding]; other site 290399008583 putative substrate binding site [chemical binding]; other site 290399008584 catalytic Zn binding site [ion binding]; other site 290399008585 structural Zn binding site [ion binding]; other site 290399008586 dimer interface [polypeptide binding]; other site 290399008587 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290399008588 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 290399008589 active site residue [active] 290399008590 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290399008591 active site residue [active] 290399008592 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290399008593 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 290399008594 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399008595 catalytic residue [active] 290399008596 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 290399008597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290399008598 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290399008599 metal binding site 2 [ion binding]; metal-binding site 290399008600 putative DNA binding helix; other site 290399008601 metal binding site 1 [ion binding]; metal-binding site 290399008602 dimer interface [polypeptide binding]; other site 290399008603 structural Zn2+ binding site [ion binding]; other site 290399008604 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290399008605 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290399008606 putative PBP binding regions; other site 290399008607 ABC-ATPase subunit interface; other site 290399008608 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290399008609 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290399008610 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290399008611 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290399008612 intersubunit interface [polypeptide binding]; other site 290399008613 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290399008614 Domain of unknown function DUF21; Region: DUF21; pfam01595 290399008615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290399008616 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290399008617 Domain of unknown function DUF21; Region: DUF21; pfam01595 290399008618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290399008619 Transporter associated domain; Region: CorC_HlyC; smart01091 290399008620 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 290399008621 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290399008622 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 290399008623 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290399008624 active site 290399008625 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 290399008626 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290399008627 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 290399008628 TPP-binding site [chemical binding]; other site 290399008629 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 290399008630 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 290399008631 active site 290399008632 catalytic triad [active] 290399008633 oxyanion hole [active] 290399008634 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290399008635 Beta-lactamase; Region: Beta-lactamase; pfam00144 290399008636 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 290399008637 Predicted transcriptional regulators [Transcription]; Region: COG1695 290399008638 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399008639 putative DNA binding site [nucleotide binding]; other site 290399008640 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 290399008641 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 290399008642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399008643 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399008644 DNA binding residues [nucleotide binding] 290399008645 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 290399008646 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 290399008647 hinge; other site 290399008648 active site 290399008649 GTPase RsgA; Reviewed; Region: PRK00098 290399008650 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290399008651 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290399008652 GTP/Mg2+ binding site [chemical binding]; other site 290399008653 G4 box; other site 290399008654 G5 box; other site 290399008655 G1 box; other site 290399008656 Switch I region; other site 290399008657 G2 box; other site 290399008658 G3 box; other site 290399008659 Switch II region; other site 290399008660 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290399008661 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 290399008662 active site 290399008663 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 290399008664 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290399008665 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399008666 catalytic residue [active] 290399008667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399008668 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290399008669 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290399008670 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290399008671 FeoA domain; Region: FeoA; pfam04023 290399008672 CrcB-like protein; Region: CRCB; pfam02537 290399008673 CrcB-like protein; Region: CRCB; pfam02537 290399008674 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 290399008675 SmpB-tmRNA interface; other site 290399008676 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 290399008677 Peptidase family M23; Region: Peptidase_M23; pfam01551 290399008678 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 290399008679 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 290399008680 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 290399008681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399008682 Walker A/P-loop; other site 290399008683 ATP binding site [chemical binding]; other site 290399008684 Q-loop/lid; other site 290399008685 ABC transporter signature motif; other site 290399008686 Walker B; other site 290399008687 D-loop; other site 290399008688 H-loop/switch region; other site 290399008689 peptide chain release factor 2; Validated; Region: prfB; PRK00578 290399008690 This domain is found in peptide chain release factors; Region: PCRF; smart00937 290399008691 RF-1 domain; Region: RF-1; pfam00472 290399008692 TadE-like protein; Region: TadE; pfam07811 290399008693 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290399008694 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290399008695 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290399008696 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290399008697 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 290399008698 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290399008699 ATP binding site [chemical binding]; other site 290399008700 Walker A motif; other site 290399008701 hexamer interface [polypeptide binding]; other site 290399008702 Walker B motif; other site 290399008703 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 290399008704 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 290399008705 active site 290399008706 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290399008707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399008708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399008709 active site 290399008710 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 290399008711 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 290399008712 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 290399008713 NADP binding site [chemical binding]; other site 290399008714 active site 290399008715 putative substrate binding site [chemical binding]; other site 290399008716 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290399008717 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 290399008718 NAD binding site [chemical binding]; other site 290399008719 substrate binding site [chemical binding]; other site 290399008720 homodimer interface [polypeptide binding]; other site 290399008721 active site 290399008722 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 290399008723 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290399008724 Probable Catalytic site; other site 290399008725 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290399008726 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 290399008727 Ligand binding site; other site 290399008728 Putative Catalytic site; other site 290399008729 DXD motif; other site 290399008730 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 290399008731 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399008732 active site 290399008733 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399008734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399008735 NAD(P) binding site [chemical binding]; other site 290399008736 active site 290399008737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399008738 active site 290399008739 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290399008740 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290399008741 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290399008742 substrate binding site; other site 290399008743 tetramer interface; other site 290399008744 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290399008745 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 290399008746 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 290399008747 Walker A/P-loop; other site 290399008748 ATP binding site [chemical binding]; other site 290399008749 Q-loop/lid; other site 290399008750 ABC transporter signature motif; other site 290399008751 Walker B; other site 290399008752 D-loop; other site 290399008753 H-loop/switch region; other site 290399008754 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 290399008755 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290399008756 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399008757 active site 290399008758 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 290399008759 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399008760 UDP-galactopyranose mutase; Region: GLF; pfam03275 290399008761 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 290399008762 phosphopeptide binding site; other site 290399008763 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290399008764 Transcription factor WhiB; Region: Whib; pfam02467 290399008765 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 290399008766 PAS fold; Region: PAS_4; pfam08448 290399008767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 290399008768 Histidine kinase; Region: HisKA_2; pfam07568 290399008769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399008770 ATP binding site [chemical binding]; other site 290399008771 Mg2+ binding site [ion binding]; other site 290399008772 G-X-G motif; other site 290399008773 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 290399008774 AAA domain; Region: AAA_31; pfam13614 290399008775 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290399008776 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399008777 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290399008778 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 290399008779 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 290399008780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 290399008781 nucleotide binding region [chemical binding]; other site 290399008782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 290399008783 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290399008784 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 290399008785 30S subunit binding site; other site 290399008786 comF family protein; Region: comF; TIGR00201 290399008787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399008788 active site 290399008789 lipoprotein LpqB; Provisional; Region: PRK13614 290399008790 Sporulation and spore germination; Region: Germane; pfam10646 290399008791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290399008792 dimerization interface [polypeptide binding]; other site 290399008793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399008794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399008795 dimer interface [polypeptide binding]; other site 290399008796 phosphorylation site [posttranslational modification] 290399008797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399008798 ATP binding site [chemical binding]; other site 290399008799 Mg2+ binding site [ion binding]; other site 290399008800 G-X-G motif; other site 290399008801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399008802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399008803 active site 290399008804 phosphorylation site [posttranslational modification] 290399008805 intermolecular recognition site; other site 290399008806 dimerization interface [polypeptide binding]; other site 290399008807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399008808 DNA binding site [nucleotide binding] 290399008809 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 290399008810 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 290399008811 MoxR-like ATPases [General function prediction only]; Region: COG0714 290399008812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399008813 Walker A motif; other site 290399008814 ATP binding site [chemical binding]; other site 290399008815 Walker B motif; other site 290399008816 arginine finger; other site 290399008817 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290399008818 Protein of unknown function DUF58; Region: DUF58; pfam01882 290399008819 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 290399008820 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 290399008821 chorismate mutase; Provisional; Region: PRK09239 290399008822 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290399008823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399008824 Walker A/P-loop; other site 290399008825 ATP binding site [chemical binding]; other site 290399008826 Q-loop/lid; other site 290399008827 ABC transporter signature motif; other site 290399008828 Walker B; other site 290399008829 D-loop; other site 290399008830 H-loop/switch region; other site 290399008831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399008832 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399008833 Walker A/P-loop; other site 290399008834 ATP binding site [chemical binding]; other site 290399008835 Q-loop/lid; other site 290399008836 ABC transporter signature motif; other site 290399008837 Walker B; other site 290399008838 D-loop; other site 290399008839 H-loop/switch region; other site 290399008840 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399008841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290399008842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399008843 dimer interface [polypeptide binding]; other site 290399008844 conserved gate region; other site 290399008845 ABC-ATPase subunit interface; other site 290399008846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399008847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399008848 dimer interface [polypeptide binding]; other site 290399008849 conserved gate region; other site 290399008850 putative PBP binding loops; other site 290399008851 ABC-ATPase subunit interface; other site 290399008852 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 290399008853 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290399008854 Caspase domain; Region: Peptidase_C14; pfam00656 290399008855 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 290399008856 Zn binding site [ion binding]; other site 290399008857 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 290399008858 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 290399008859 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 290399008860 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399008861 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 290399008862 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 290399008863 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399008864 catalytic residue [active] 290399008865 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 290399008866 EamA-like transporter family; Region: EamA; pfam00892 290399008867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399008868 Predicted transcriptional regulator [Transcription]; Region: COG2345 290399008869 putative DNA binding site [nucleotide binding]; other site 290399008870 putative Zn2+ binding site [ion binding]; other site 290399008871 diacylglycerol kinase; Reviewed; Region: PRK11914 290399008872 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290399008873 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290399008874 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 290399008875 HSP70 interaction site [polypeptide binding]; other site 290399008876 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 290399008877 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 290399008878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399008879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399008880 DNA binding residues [nucleotide binding] 290399008881 Anti-sigma-K factor rskA; Region: RskA; pfam10099 290399008882 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 290399008883 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 290399008884 DNA binding residues [nucleotide binding] 290399008885 dimer interface [polypeptide binding]; other site 290399008886 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 290399008887 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 290399008888 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 290399008889 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290399008890 Ligand Binding Site [chemical binding]; other site 290399008891 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 290399008892 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 290399008893 Ligand binding site [chemical binding]; other site 290399008894 Electron transfer flavoprotein domain; Region: ETF; pfam01012 290399008895 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290399008896 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290399008897 Repair protein; Region: Repair_PSII; cl01535 290399008898 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 290399008899 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 290399008900 active site 290399008901 oxyanion hole [active] 290399008902 DNA photolyase; Region: DNA_photolyase; pfam00875 290399008903 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 290399008904 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 290399008905 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 290399008906 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 290399008907 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 290399008908 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290399008909 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 290399008910 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 290399008911 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 290399008912 Protein of unknown function DUF45; Region: DUF45; cl00636 290399008913 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 290399008914 Part of AAA domain; Region: AAA_19; pfam13245 290399008915 Family description; Region: UvrD_C_2; pfam13538 290399008916 HRDC domain; Region: HRDC; pfam00570 290399008917 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 290399008918 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 290399008919 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 290399008920 putative NADH binding site [chemical binding]; other site 290399008921 putative active site [active] 290399008922 nudix motif; other site 290399008923 putative metal binding site [ion binding]; other site 290399008924 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290399008925 Phosphotransferase enzyme family; Region: APH; pfam01636 290399008926 active site 290399008927 ATP binding site [chemical binding]; other site 290399008928 substrate binding site [chemical binding]; other site 290399008929 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290399008930 Part of AAA domain; Region: AAA_19; pfam13245 290399008931 Family description; Region: UvrD_C_2; pfam13538 290399008932 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 290399008933 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 290399008934 Part of AAA domain; Region: AAA_19; pfam13245 290399008935 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 290399008936 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 290399008937 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290399008938 DNA binding site [nucleotide binding] 290399008939 active site 290399008940 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290399008941 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 290399008942 active site 290399008943 catalytic site [active] 290399008944 substrate binding site [chemical binding]; other site 290399008945 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 290399008946 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 290399008947 Walker A/P-loop; other site 290399008948 ATP binding site [chemical binding]; other site 290399008949 Q-loop/lid; other site 290399008950 ABC transporter signature motif; other site 290399008951 Walker B; other site 290399008952 D-loop; other site 290399008953 H-loop/switch region; other site 290399008954 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 290399008955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399008956 dimer interface [polypeptide binding]; other site 290399008957 conserved gate region; other site 290399008958 ABC-ATPase subunit interface; other site 290399008959 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 290399008960 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 290399008961 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 290399008962 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290399008963 inhibitor-cofactor binding pocket; inhibition site 290399008964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399008965 catalytic residue [active] 290399008966 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290399008967 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 290399008968 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 290399008969 dimer interface [polypeptide binding]; other site 290399008970 active site 290399008971 Schiff base residues; other site 290399008972 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 290399008973 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290399008974 active site 290399008975 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 290399008976 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 290399008977 ferrochelatase; Reviewed; Region: hemH; PRK00035 290399008978 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290399008979 C-terminal domain interface [polypeptide binding]; other site 290399008980 active site 290399008981 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290399008982 active site 290399008983 N-terminal domain interface [polypeptide binding]; other site 290399008984 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 290399008985 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 290399008986 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399008987 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 290399008988 substrate binding site [chemical binding]; other site 290399008989 active site 290399008990 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 290399008991 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 290399008992 NAD(P) binding pocket [chemical binding]; other site 290399008993 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 290399008994 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 290399008995 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290399008996 ATP binding site [chemical binding]; other site 290399008997 substrate interface [chemical binding]; other site 290399008998 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290399008999 active site residue [active] 290399009000 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399009001 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399009002 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 290399009003 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 290399009004 aromatic arch; other site 290399009005 DCoH dimer interaction site [polypeptide binding]; other site 290399009006 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 290399009007 DCoH tetramer interaction site [polypeptide binding]; other site 290399009008 substrate binding site [chemical binding]; other site 290399009009 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 290399009010 ThiS interaction site; other site 290399009011 putative active site [active] 290399009012 tetramer interface [polypeptide binding]; other site 290399009013 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 290399009014 thiS-thiF/thiG interaction site; other site 290399009015 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 290399009016 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290399009017 thiamine phosphate binding site [chemical binding]; other site 290399009018 active site 290399009019 pyrophosphate binding site [ion binding]; other site 290399009020 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 290399009021 dinuclear metal binding motif [ion binding]; other site 290399009022 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 290399009023 RNB domain; Region: RNB; pfam00773 290399009024 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290399009025 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290399009026 ATP binding site [chemical binding]; other site 290399009027 Mg++ binding site [ion binding]; other site 290399009028 motif III; other site 290399009029 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399009030 nucleotide binding region [chemical binding]; other site 290399009031 ATP-binding site [chemical binding]; other site 290399009032 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290399009033 DNA methylase; Region: N6_N4_Mtase; pfam01555 290399009034 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290399009035 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 290399009036 active site 290399009037 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290399009038 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 290399009039 proline aminopeptidase P II; Provisional; Region: PRK10879 290399009040 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 290399009041 active site 290399009042 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 290399009043 Serine incorporator (Serinc); Region: Serinc; pfam03348 290399009044 PRC-barrel domain; Region: PRC; pfam05239 290399009045 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 290399009046 MgtE intracellular N domain; Region: MgtE_N; smart00924 290399009047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 290399009048 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 290399009049 Domain of unknown function DUF59; Region: DUF59; pfam01883 290399009050 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 290399009051 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 290399009052 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 290399009053 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 290399009054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399009055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399009056 DNA binding residues [nucleotide binding] 290399009057 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 290399009058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399009059 S-adenosylmethionine binding site [chemical binding]; other site 290399009060 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 290399009061 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 290399009062 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399009063 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290399009064 Walker A/P-loop; other site 290399009065 ATP binding site [chemical binding]; other site 290399009066 Q-loop/lid; other site 290399009067 ABC transporter signature motif; other site 290399009068 Walker B; other site 290399009069 D-loop; other site 290399009070 H-loop/switch region; other site 290399009071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399009072 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290399009073 substrate binding pocket [chemical binding]; other site 290399009074 membrane-bound complex binding site; other site 290399009075 hinge residues; other site 290399009076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009077 dimer interface [polypeptide binding]; other site 290399009078 conserved gate region; other site 290399009079 putative PBP binding loops; other site 290399009080 ABC-ATPase subunit interface; other site 290399009081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290399009082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009083 putative PBP binding loops; other site 290399009084 ABC-ATPase subunit interface; other site 290399009085 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 290399009086 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 290399009087 metal binding site [ion binding]; metal-binding site 290399009088 putative dimer interface [polypeptide binding]; other site 290399009089 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 290399009090 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 290399009091 putative trimer interface [polypeptide binding]; other site 290399009092 putative CoA binding site [chemical binding]; other site 290399009093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399009094 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290399009095 UDP-glucose 4-epimerase; Region: PLN02240 290399009096 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 290399009097 NAD binding site [chemical binding]; other site 290399009098 homodimer interface [polypeptide binding]; other site 290399009099 active site 290399009100 substrate binding site [chemical binding]; other site 290399009101 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 290399009102 dimer interface [polypeptide binding]; other site 290399009103 Citrate synthase; Region: Citrate_synt; pfam00285 290399009104 active site 290399009105 citrylCoA binding site [chemical binding]; other site 290399009106 NADH binding [chemical binding]; other site 290399009107 cationic pore residues; other site 290399009108 oxalacetate/citrate binding site [chemical binding]; other site 290399009109 coenzyme A binding site [chemical binding]; other site 290399009110 catalytic triad [active] 290399009111 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 290399009112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399009113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399009114 homodimer interface [polypeptide binding]; other site 290399009115 catalytic residue [active] 290399009116 Ferredoxin [Energy production and conversion]; Region: COG1146 290399009117 4Fe-4S binding domain; Region: Fer4; pfam00037 290399009118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399009119 dimerization interface [polypeptide binding]; other site 290399009120 putative DNA binding site [nucleotide binding]; other site 290399009121 putative Zn2+ binding site [ion binding]; other site 290399009122 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 290399009123 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 290399009124 G1 box; other site 290399009125 putative GEF interaction site [polypeptide binding]; other site 290399009126 GTP/Mg2+ binding site [chemical binding]; other site 290399009127 Switch I region; other site 290399009128 G2 box; other site 290399009129 G3 box; other site 290399009130 Switch II region; other site 290399009131 G4 box; other site 290399009132 G5 box; other site 290399009133 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 290399009134 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 290399009135 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 290399009136 active site 290399009137 catalytic triad [active] 290399009138 oxyanion hole [active] 290399009139 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290399009140 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399009141 Walker A/P-loop; other site 290399009142 ATP binding site [chemical binding]; other site 290399009143 Q-loop/lid; other site 290399009144 ABC transporter signature motif; other site 290399009145 Walker B; other site 290399009146 D-loop; other site 290399009147 H-loop/switch region; other site 290399009148 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290399009149 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399009150 Walker A/P-loop; other site 290399009151 ATP binding site [chemical binding]; other site 290399009152 Q-loop/lid; other site 290399009153 ABC transporter signature motif; other site 290399009154 Walker B; other site 290399009155 D-loop; other site 290399009156 H-loop/switch region; other site 290399009157 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399009158 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290399009159 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290399009160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009161 dimer interface [polypeptide binding]; other site 290399009162 conserved gate region; other site 290399009163 putative PBP binding loops; other site 290399009164 ABC-ATPase subunit interface; other site 290399009165 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399009166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009167 dimer interface [polypeptide binding]; other site 290399009168 conserved gate region; other site 290399009169 ABC-ATPase subunit interface; other site 290399009170 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 290399009171 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 290399009172 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290399009173 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399009174 Walker A/P-loop; other site 290399009175 ATP binding site [chemical binding]; other site 290399009176 Q-loop/lid; other site 290399009177 ABC transporter signature motif; other site 290399009178 Walker B; other site 290399009179 D-loop; other site 290399009180 H-loop/switch region; other site 290399009181 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399009182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399009183 Walker A/P-loop; other site 290399009184 ATP binding site [chemical binding]; other site 290399009185 Q-loop/lid; other site 290399009186 ABC transporter signature motif; other site 290399009187 Walker B; other site 290399009188 D-loop; other site 290399009189 H-loop/switch region; other site 290399009190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290399009191 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 290399009192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290399009193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009194 dimer interface [polypeptide binding]; other site 290399009195 ABC-ATPase subunit interface; other site 290399009196 putative PBP binding loops; other site 290399009197 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399009198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399009199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009200 putative PBP binding loops; other site 290399009201 dimer interface [polypeptide binding]; other site 290399009202 ABC-ATPase subunit interface; other site 290399009203 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290399009204 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 290399009205 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 290399009206 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 290399009207 active site 290399009208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 290399009209 phosphorylation site [posttranslational modification] 290399009210 intermolecular recognition site; other site 290399009211 GTP-binding protein YchF; Reviewed; Region: PRK09601 290399009212 YchF GTPase; Region: YchF; cd01900 290399009213 G1 box; other site 290399009214 GTP/Mg2+ binding site [chemical binding]; other site 290399009215 Switch I region; other site 290399009216 G2 box; other site 290399009217 Switch II region; other site 290399009218 G3 box; other site 290399009219 G4 box; other site 290399009220 G5 box; other site 290399009221 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 290399009222 RmuC family; Region: RmuC; pfam02646 290399009223 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 290399009224 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 290399009225 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 290399009226 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 290399009227 generic binding surface II; other site 290399009228 generic binding surface I; other site 290399009229 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 290399009230 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 290399009231 aminotransferase AlaT; Validated; Region: PRK09265 290399009232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399009233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399009234 homodimer interface [polypeptide binding]; other site 290399009235 catalytic residue [active] 290399009236 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 290399009237 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399009238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009239 ABC-ATPase subunit interface; other site 290399009240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009241 dimer interface [polypeptide binding]; other site 290399009242 conserved gate region; other site 290399009243 ABC-ATPase subunit interface; other site 290399009244 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 290399009245 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 290399009246 Walker A/P-loop; other site 290399009247 ATP binding site [chemical binding]; other site 290399009248 Q-loop/lid; other site 290399009249 ABC transporter signature motif; other site 290399009250 Walker B; other site 290399009251 D-loop; other site 290399009252 H-loop/switch region; other site 290399009253 Dehydratase medium subunit; Region: Dehydratase_MU; cl17703 290399009254 GTPase RsgA; Reviewed; Region: PRK01889 290399009255 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290399009256 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290399009257 GTP/Mg2+ binding site [chemical binding]; other site 290399009258 G4 box; other site 290399009259 G5 box; other site 290399009260 G1 box; other site 290399009261 Switch I region; other site 290399009262 G2 box; other site 290399009263 G3 box; other site 290399009264 Switch II region; other site 290399009265 Pirin-related protein [General function prediction only]; Region: COG1741 290399009266 Pirin; Region: Pirin; pfam02678 290399009267 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 290399009268 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 290399009269 Nitronate monooxygenase; Region: NMO; pfam03060 290399009270 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 290399009271 FMN binding site [chemical binding]; other site 290399009272 substrate binding site [chemical binding]; other site 290399009273 putative catalytic residue [active] 290399009274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399009275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399009276 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 290399009277 putative dimerization interface [polypeptide binding]; other site 290399009278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399009279 putative substrate translocation pore; other site 290399009280 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 290399009281 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 290399009282 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290399009283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399009284 catalytic residue [active] 290399009285 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399009286 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290399009287 AsnC family; Region: AsnC_trans_reg; pfam01037 290399009288 Helix-turn-helix domain; Region: HTH_20; pfam12840 290399009289 dimerization interface [polypeptide binding]; other site 290399009290 putative DNA binding site [nucleotide binding]; other site 290399009291 putative Zn2+ binding site [ion binding]; other site 290399009292 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 290399009293 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290399009294 AsnC family; Region: AsnC_trans_reg; pfam01037 290399009295 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 290399009296 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 290399009297 oligomer interface [polypeptide binding]; other site 290399009298 metal binding site [ion binding]; metal-binding site 290399009299 metal binding site [ion binding]; metal-binding site 290399009300 putative Cl binding site [ion binding]; other site 290399009301 basic sphincter; other site 290399009302 hydrophobic gate; other site 290399009303 periplasmic entrance; other site 290399009304 Predicted ATPase [General function prediction only]; Region: COG1485 290399009305 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290399009306 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290399009307 Trypsin; Region: Trypsin; pfam00089 290399009308 active site 290399009309 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290399009310 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399009311 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399009312 ABC transporter; Region: ABC_tran_2; pfam12848 290399009313 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399009314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399009315 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290399009316 NAD(P) binding site [chemical binding]; other site 290399009317 active site 290399009318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290399009319 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290399009320 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290399009321 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290399009322 active site 290399009323 tetramer interface; other site 290399009324 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 290399009325 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 290399009326 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290399009327 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 290399009328 Part of AAA domain; Region: AAA_19; pfam13245 290399009329 GMP synthase; Reviewed; Region: guaA; PRK00074 290399009330 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 290399009331 AMP/PPi binding site [chemical binding]; other site 290399009332 candidate oxyanion hole; other site 290399009333 catalytic triad [active] 290399009334 potential glutamine specificity residues [chemical binding]; other site 290399009335 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 290399009336 ATP Binding subdomain [chemical binding]; other site 290399009337 Ligand Binding sites [chemical binding]; other site 290399009338 Dimerization subdomain; other site 290399009339 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 290399009340 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 290399009341 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290399009342 active site 290399009343 phosphorylation site [posttranslational modification] 290399009344 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 290399009345 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 290399009346 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290399009347 active site 290399009348 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290399009349 active site 290399009350 catalytic triad [active] 290399009351 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 290399009352 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399009353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399009354 Walker A/P-loop; other site 290399009355 ATP binding site [chemical binding]; other site 290399009356 Q-loop/lid; other site 290399009357 ABC transporter signature motif; other site 290399009358 Walker B; other site 290399009359 D-loop; other site 290399009360 H-loop/switch region; other site 290399009361 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 290399009362 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290399009363 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 290399009364 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290399009365 active site 290399009366 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290399009367 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290399009368 Domain of unknown function (DUF389); Region: DUF389; pfam04087 290399009369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 290399009370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399009371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399009372 DNA binding residues [nucleotide binding] 290399009373 dimerization interface [polypeptide binding]; other site 290399009374 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290399009375 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290399009376 ring oligomerisation interface [polypeptide binding]; other site 290399009377 ATP/Mg binding site [chemical binding]; other site 290399009378 stacking interactions; other site 290399009379 hinge regions; other site 290399009380 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290399009381 oligomerisation interface [polypeptide binding]; other site 290399009382 mobile loop; other site 290399009383 roof hairpin; other site 290399009384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399009385 S-adenosylmethionine binding site [chemical binding]; other site 290399009386 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 290399009387 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290399009388 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290399009389 shikimate binding site; other site 290399009390 NAD(P) binding site [chemical binding]; other site 290399009391 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290399009392 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290399009393 carboxylate-amine ligase; Provisional; Region: PRK13517 290399009394 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290399009395 UGMP family protein; Validated; Region: PRK09604 290399009396 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 290399009397 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 290399009398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399009399 Coenzyme A binding pocket [chemical binding]; other site 290399009400 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 290399009401 Glycoprotease family; Region: Peptidase_M22; pfam00814 290399009402 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 290399009403 alanine racemase; Reviewed; Region: alr; PRK00053 290399009404 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290399009405 active site 290399009406 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290399009407 dimer interface [polypeptide binding]; other site 290399009408 substrate binding site [chemical binding]; other site 290399009409 catalytic residues [active] 290399009410 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290399009411 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399009412 substrate binding site [chemical binding]; other site 290399009413 ATP binding site [chemical binding]; other site 290399009414 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 290399009415 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 290399009416 NAD binding site [chemical binding]; other site 290399009417 sugar binding site [chemical binding]; other site 290399009418 divalent metal binding site [ion binding]; other site 290399009419 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290399009420 dimer interface [polypeptide binding]; other site 290399009421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 290399009422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399009423 Coenzyme A binding pocket [chemical binding]; other site 290399009424 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 290399009425 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 290399009426 putative ADP-binding pocket [chemical binding]; other site 290399009427 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 290399009428 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 290399009429 Potassium binding sites [ion binding]; other site 290399009430 Cesium cation binding sites [ion binding]; other site 290399009431 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290399009432 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290399009433 putative active site [active] 290399009434 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 290399009435 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 290399009436 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290399009437 DNA binding residues [nucleotide binding] 290399009438 putative dimer interface [polypeptide binding]; other site 290399009439 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 290399009440 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 290399009441 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399009442 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399009443 active site 290399009444 catalytic tetrad [active] 290399009445 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 290399009446 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 290399009447 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 290399009448 catalytic site [active] 290399009449 active site 290399009450 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290399009451 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 290399009452 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 290399009453 active site 290399009454 catalytic site [active] 290399009455 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 290399009456 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 290399009457 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 290399009458 active site 290399009459 catalytic site [active] 290399009460 Uncharacterized conserved protein [Function unknown]; Region: COG0062 290399009461 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290399009462 putative substrate binding site [chemical binding]; other site 290399009463 putative ATP binding site [chemical binding]; other site 290399009464 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 290399009465 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290399009466 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290399009467 glutaminase active site [active] 290399009468 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290399009469 dimer interface [polypeptide binding]; other site 290399009470 active site 290399009471 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290399009472 dimer interface [polypeptide binding]; other site 290399009473 active site 290399009474 pantothenate kinase; Provisional; Region: PRK05439 290399009475 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 290399009476 ATP-binding site [chemical binding]; other site 290399009477 CoA-binding site [chemical binding]; other site 290399009478 Mg2+-binding site [ion binding]; other site 290399009479 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 290399009480 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 290399009481 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 290399009482 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 290399009483 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 290399009484 active site 290399009485 substrate binding site [chemical binding]; other site 290399009486 metal binding site [ion binding]; metal-binding site 290399009487 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 290399009488 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 290399009489 23S rRNA interface [nucleotide binding]; other site 290399009490 L3 interface [polypeptide binding]; other site 290399009491 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 290399009492 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 290399009493 TadE-like protein; Region: TadE; pfam07811 290399009494 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 290399009495 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290399009496 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 290399009497 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399009498 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 290399009499 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290399009500 ATP binding site [chemical binding]; other site 290399009501 Walker A motif; other site 290399009502 hexamer interface [polypeptide binding]; other site 290399009503 Walker B motif; other site 290399009504 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290399009505 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290399009506 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290399009507 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290399009508 Flp/Fap pilin component; Region: Flp_Fap; cl01585 290399009509 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 290399009510 TadE-like protein; Region: TadE; pfam07811 290399009511 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 290399009512 Response regulator receiver domain; Region: Response_reg; pfam00072 290399009513 AAA domain; Region: AAA_31; pfam13614 290399009514 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 290399009515 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 290399009516 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 290399009517 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 290399009518 ATP binding site [chemical binding]; other site 290399009519 Walker A motif; other site 290399009520 hexamer interface [polypeptide binding]; other site 290399009521 Walker B motif; other site 290399009522 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290399009523 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290399009524 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 290399009525 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 290399009526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399009527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399009528 active site 290399009529 phosphorylation site [posttranslational modification] 290399009530 intermolecular recognition site; other site 290399009531 dimerization interface [polypeptide binding]; other site 290399009532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399009533 DNA binding site [nucleotide binding] 290399009534 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 290399009535 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 290399009536 dimerization interface 3.5A [polypeptide binding]; other site 290399009537 active site 290399009538 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 290399009539 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 290399009540 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 290399009541 alphaNTD homodimer interface [polypeptide binding]; other site 290399009542 alphaNTD - beta interaction site [polypeptide binding]; other site 290399009543 alphaNTD - beta' interaction site [polypeptide binding]; other site 290399009544 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 290399009545 30S ribosomal protein S11; Validated; Region: PRK05309 290399009546 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 290399009547 30S ribosomal protein S13; Region: bact_S13; TIGR03631 290399009548 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 290399009549 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 290399009550 rRNA binding site [nucleotide binding]; other site 290399009551 predicted 30S ribosome binding site; other site 290399009552 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 290399009553 putative active site pocket [active] 290399009554 cleavage site 290399009555 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399009556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009557 dimer interface [polypeptide binding]; other site 290399009558 conserved gate region; other site 290399009559 putative PBP binding loops; other site 290399009560 ABC-ATPase subunit interface; other site 290399009561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399009562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009563 dimer interface [polypeptide binding]; other site 290399009564 conserved gate region; other site 290399009565 putative PBP binding loops; other site 290399009566 ABC-ATPase subunit interface; other site 290399009567 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290399009568 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399009569 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290399009570 active site 290399009571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399009572 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 290399009573 NAD(P) binding site [chemical binding]; other site 290399009574 active site 290399009575 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 290399009576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399009577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399009578 acyl-activating enzyme (AAE) consensus motif; other site 290399009579 AMP binding site [chemical binding]; other site 290399009580 active site 290399009581 CoA binding site [chemical binding]; other site 290399009582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 290399009583 Cytochrome P450; Region: p450; cl12078 290399009584 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290399009585 DXD motif; other site 290399009586 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 290399009587 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 290399009588 active site 290399009589 adenylate kinase; Reviewed; Region: adk; PRK00279 290399009590 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290399009591 AMP-binding site [chemical binding]; other site 290399009592 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290399009593 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 290399009594 SecY translocase; Region: SecY; pfam00344 290399009595 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 290399009596 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 290399009597 23S rRNA binding site [nucleotide binding]; other site 290399009598 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 290399009599 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 290399009600 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 290399009601 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 290399009602 5S rRNA interface [nucleotide binding]; other site 290399009603 23S rRNA interface [nucleotide binding]; other site 290399009604 L5 interface [polypeptide binding]; other site 290399009605 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 290399009606 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290399009607 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290399009608 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 290399009609 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 290399009610 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 290399009611 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 290399009612 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 290399009613 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 290399009614 RNA binding site [nucleotide binding]; other site 290399009615 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 290399009616 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 290399009617 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 290399009618 23S rRNA interface [nucleotide binding]; other site 290399009619 putative translocon interaction site; other site 290399009620 signal recognition particle (SRP54) interaction site; other site 290399009621 L23 interface [polypeptide binding]; other site 290399009622 trigger factor interaction site; other site 290399009623 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 290399009624 23S rRNA interface [nucleotide binding]; other site 290399009625 5S rRNA interface [nucleotide binding]; other site 290399009626 putative antibiotic binding site [chemical binding]; other site 290399009627 L25 interface [polypeptide binding]; other site 290399009628 L27 interface [polypeptide binding]; other site 290399009629 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 290399009630 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 290399009631 G-X-X-G motif; other site 290399009632 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 290399009633 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 290399009634 putative translocon binding site; other site 290399009635 protein-rRNA interface [nucleotide binding]; other site 290399009636 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 290399009637 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 290399009638 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 290399009639 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 290399009640 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 290399009641 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 290399009642 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 290399009643 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 290399009644 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290399009645 beta-galactosidase; Region: BGL; TIGR03356 290399009646 elongation factor Tu; Reviewed; Region: PRK00049 290399009647 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290399009648 G1 box; other site 290399009649 GEF interaction site [polypeptide binding]; other site 290399009650 GTP/Mg2+ binding site [chemical binding]; other site 290399009651 Switch I region; other site 290399009652 G2 box; other site 290399009653 G3 box; other site 290399009654 Switch II region; other site 290399009655 G4 box; other site 290399009656 G5 box; other site 290399009657 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290399009658 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290399009659 Antibiotic Binding Site [chemical binding]; other site 290399009660 elongation factor G; Reviewed; Region: PRK00007 290399009661 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 290399009662 G1 box; other site 290399009663 putative GEF interaction site [polypeptide binding]; other site 290399009664 GTP/Mg2+ binding site [chemical binding]; other site 290399009665 Switch I region; other site 290399009666 G2 box; other site 290399009667 G3 box; other site 290399009668 Switch II region; other site 290399009669 G4 box; other site 290399009670 G5 box; other site 290399009671 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290399009672 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290399009673 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290399009674 30S ribosomal protein S7; Validated; Region: PRK05302 290399009675 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 290399009676 S17 interaction site [polypeptide binding]; other site 290399009677 S8 interaction site; other site 290399009678 16S rRNA interaction site [nucleotide binding]; other site 290399009679 streptomycin interaction site [chemical binding]; other site 290399009680 23S rRNA interaction site [nucleotide binding]; other site 290399009681 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 290399009682 DNA-directed RNA polymerase, gamma subunit; Region: rpoC1_cyan; TIGR02387 290399009683 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 290399009684 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 290399009685 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 290399009686 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 290399009687 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290399009688 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 290399009689 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 290399009690 DNA binding site [nucleotide binding] 290399009691 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 290399009692 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 290399009693 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 290399009694 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 290399009695 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 290399009696 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290399009697 RPB10 interaction site [polypeptide binding]; other site 290399009698 RPB1 interaction site [polypeptide binding]; other site 290399009699 RPB11 interaction site [polypeptide binding]; other site 290399009700 RPB3 interaction site [polypeptide binding]; other site 290399009701 RPB12 interaction site [polypeptide binding]; other site 290399009702 putative acyltransferase; Provisional; Region: PRK05790 290399009703 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290399009704 dimer interface [polypeptide binding]; other site 290399009705 active site 290399009706 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 290399009707 putative deacylase active site [active] 290399009708 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 290399009709 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 290399009710 active site 290399009711 metal binding site [ion binding]; metal-binding site 290399009712 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 290399009713 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 290399009714 core dimer interface [polypeptide binding]; other site 290399009715 peripheral dimer interface [polypeptide binding]; other site 290399009716 L10 interface [polypeptide binding]; other site 290399009717 L11 interface [polypeptide binding]; other site 290399009718 putative EF-Tu interaction site [polypeptide binding]; other site 290399009719 putative EF-G interaction site [polypeptide binding]; other site 290399009720 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 290399009721 23S rRNA interface [nucleotide binding]; other site 290399009722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399009723 Coenzyme A binding pocket [chemical binding]; other site 290399009724 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 290399009725 mRNA/rRNA interface [nucleotide binding]; other site 290399009726 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 290399009727 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 290399009728 23S rRNA interface [nucleotide binding]; other site 290399009729 putative thiostrepton binding site; other site 290399009730 L7/L12 interface [polypeptide binding]; other site 290399009731 L25 interface [polypeptide binding]; other site 290399009732 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 290399009733 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 290399009734 putative homodimer interface [polypeptide binding]; other site 290399009735 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 290399009736 heterodimer interface [polypeptide binding]; other site 290399009737 homodimer interface [polypeptide binding]; other site 290399009738 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 290399009739 aspartate aminotransferase; Provisional; Region: PRK05764 290399009740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399009741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399009742 homodimer interface [polypeptide binding]; other site 290399009743 catalytic residue [active] 290399009744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399009745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399009746 active site 290399009747 phosphorylation site [posttranslational modification] 290399009748 intermolecular recognition site; other site 290399009749 dimerization interface [polypeptide binding]; other site 290399009750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399009751 DNA binding residues [nucleotide binding] 290399009752 dimerization interface [polypeptide binding]; other site 290399009753 PspC domain; Region: PspC; pfam04024 290399009754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290399009755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399009756 ATP binding site [chemical binding]; other site 290399009757 Mg2+ binding site [ion binding]; other site 290399009758 G-X-G motif; other site 290399009759 PspC domain; Region: PspC; pfam04024 290399009760 PspC domain; Region: PspC; pfam04024 290399009761 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 290399009762 phosphofructokinase; Region: PFK_mixed; TIGR02483 290399009763 active site 290399009764 ADP/pyrophosphate binding site [chemical binding]; other site 290399009765 dimerization interface [polypeptide binding]; other site 290399009766 allosteric effector site; other site 290399009767 fructose-1,6-bisphosphate binding site; other site 290399009768 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 290399009769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399009770 putative substrate translocation pore; other site 290399009771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399009772 Predicted transcriptional regulators [Transcription]; Region: COG1695 290399009773 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 290399009774 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 290399009775 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 290399009776 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 290399009777 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 290399009778 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290399009779 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290399009780 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 290399009781 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 290399009782 heme-binding site [chemical binding]; other site 290399009783 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399009784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399009785 DNA binding site [nucleotide binding] 290399009786 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 290399009787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399009788 Coenzyme A binding pocket [chemical binding]; other site 290399009789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399009790 Coenzyme A binding pocket [chemical binding]; other site 290399009791 polyphosphate kinase; Provisional; Region: PRK05443 290399009792 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 290399009793 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 290399009794 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 290399009795 putative domain interface [polypeptide binding]; other site 290399009796 putative active site [active] 290399009797 catalytic site [active] 290399009798 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 290399009799 putative domain interface [polypeptide binding]; other site 290399009800 putative active site [active] 290399009801 catalytic site [active] 290399009802 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 290399009803 active site 290399009804 Ap6A binding site [chemical binding]; other site 290399009805 nudix motif; other site 290399009806 metal binding site [ion binding]; metal-binding site 290399009807 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399009808 catalytic core [active] 290399009809 Predicted transcriptional regulators [Transcription]; Region: COG1725 290399009810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399009811 DNA-binding site [nucleotide binding]; DNA binding site 290399009812 thymidylate synthase; Reviewed; Region: thyA; PRK01827 290399009813 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 290399009814 dimerization interface [polypeptide binding]; other site 290399009815 active site 290399009816 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 290399009817 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 290399009818 folate binding site [chemical binding]; other site 290399009819 NADP+ binding site [chemical binding]; other site 290399009820 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290399009821 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 290399009822 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290399009823 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 290399009824 FAD binding domain; Region: FAD_binding_4; pfam01565 290399009825 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 290399009826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399009827 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 290399009828 active site 290399009829 catalytic site [active] 290399009830 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 290399009831 active site 290399009832 catalytic site [active] 290399009833 dimerization interface [polypeptide binding]; other site 290399009834 putative DNA binding site [nucleotide binding]; other site 290399009835 putative Zn2+ binding site [ion binding]; other site 290399009836 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 290399009837 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290399009838 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290399009839 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290399009840 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290399009841 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 290399009842 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 290399009843 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 290399009844 NMT1/THI5 like; Region: NMT1; pfam09084 290399009845 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 290399009846 membrane-bound complex binding site; other site 290399009847 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290399009848 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290399009849 Walker A/P-loop; other site 290399009850 ATP binding site [chemical binding]; other site 290399009851 Q-loop/lid; other site 290399009852 ABC transporter signature motif; other site 290399009853 Walker B; other site 290399009854 D-loop; other site 290399009855 H-loop/switch region; other site 290399009856 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399009857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009858 dimer interface [polypeptide binding]; other site 290399009859 conserved gate region; other site 290399009860 putative PBP binding loops; other site 290399009861 ABC-ATPase subunit interface; other site 290399009862 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 290399009863 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 290399009864 active site 290399009865 iron coordination sites [ion binding]; other site 290399009866 substrate binding pocket [chemical binding]; other site 290399009867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399009868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399009869 active site 290399009870 catalytic tetrad [active] 290399009871 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 290399009872 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 290399009873 active site 290399009874 catalytic site [active] 290399009875 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 290399009876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399009877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009878 putative PBP binding loops; other site 290399009879 dimer interface [polypeptide binding]; other site 290399009880 ABC-ATPase subunit interface; other site 290399009881 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290399009882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399009883 dimer interface [polypeptide binding]; other site 290399009884 conserved gate region; other site 290399009885 putative PBP binding loops; other site 290399009886 ABC-ATPase subunit interface; other site 290399009887 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399009888 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399009889 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399009890 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290399009891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290399009892 nucleotide binding site [chemical binding]; other site 290399009893 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 290399009894 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290399009895 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290399009896 NAD(P) binding site [chemical binding]; other site 290399009897 putative active site [active] 290399009898 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290399009899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399009900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399009901 DNA binding residues [nucleotide binding] 290399009902 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 290399009903 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 290399009904 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290399009905 ATP binding site [chemical binding]; other site 290399009906 Mg++ binding site [ion binding]; other site 290399009907 motif III; other site 290399009908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399009909 nucleotide binding region [chemical binding]; other site 290399009910 ATP-binding site [chemical binding]; other site 290399009911 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 290399009912 putative RNA binding site [nucleotide binding]; other site 290399009913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 290399009914 MOSC domain; Region: MOSC; pfam03473 290399009915 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 290399009916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399009917 active site 290399009918 phosphorylation site [posttranslational modification] 290399009919 intermolecular recognition site; other site 290399009920 dimerization interface [polypeptide binding]; other site 290399009921 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399009922 DNA binding site [nucleotide binding] 290399009923 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 290399009924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399009925 dimer interface [polypeptide binding]; other site 290399009926 phosphorylation site [posttranslational modification] 290399009927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399009928 ATP binding site [chemical binding]; other site 290399009929 Mg2+ binding site [ion binding]; other site 290399009930 G-X-G motif; other site 290399009931 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 290399009932 Amino acid permease; Region: AA_permease_2; pfam13520 290399009933 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399009934 acyl-coenzyme A oxidase; Region: PLN02526 290399009935 active site 290399009936 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 290399009937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399009938 NAD(P) binding site [chemical binding]; other site 290399009939 active site 290399009940 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 290399009941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399009942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399009943 Predicted transcriptional regulators [Transcription]; Region: COG1733 290399009944 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290399009945 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 290399009946 cystathionine gamma-synthase; Provisional; Region: PRK07811 290399009947 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290399009948 homodimer interface [polypeptide binding]; other site 290399009949 substrate-cofactor binding pocket; other site 290399009950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399009951 catalytic residue [active] 290399009952 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 290399009953 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290399009954 dimer interface [polypeptide binding]; other site 290399009955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399009956 catalytic residue [active] 290399009957 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 290399009958 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290399009959 transmembrane helices; other site 290399009960 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399009961 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399009962 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 290399009963 AMP-binding domain protein; Validated; Region: PRK08315 290399009964 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399009965 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 290399009966 acyl-activating enzyme (AAE) consensus motif; other site 290399009967 putative AMP binding site [chemical binding]; other site 290399009968 putative active site [active] 290399009969 putative CoA binding site [chemical binding]; other site 290399009970 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290399009971 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290399009972 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290399009973 catalytic residues [active] 290399009974 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290399009975 active site 290399009976 Ion channel; Region: Ion_trans_2; pfam07885 290399009977 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290399009978 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 290399009979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 290399009980 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 290399009981 heat shock protein HtpX; Provisional; Region: PRK03072 290399009982 enterobactin exporter EntS; Provisional; Region: PRK10489 290399009983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399009984 putative substrate translocation pore; other site 290399009985 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290399009986 metal binding site 2 [ion binding]; metal-binding site 290399009987 putative DNA binding helix; other site 290399009988 metal binding site 1 [ion binding]; metal-binding site 290399009989 structural Zn2+ binding site [ion binding]; other site 290399009990 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 290399009991 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 290399009992 tetramer interface [polypeptide binding]; other site 290399009993 heme binding pocket [chemical binding]; other site 290399009994 NADPH binding site [chemical binding]; other site 290399009995 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 290399009996 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290399009997 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290399009998 Walker A/P-loop; other site 290399009999 ATP binding site [chemical binding]; other site 290399010000 Q-loop/lid; other site 290399010001 ABC transporter signature motif; other site 290399010002 Walker B; other site 290399010003 D-loop; other site 290399010004 H-loop/switch region; other site 290399010005 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399010006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010007 putative PBP binding loops; other site 290399010008 ABC-ATPase subunit interface; other site 290399010009 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399010010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010011 dimer interface [polypeptide binding]; other site 290399010012 conserved gate region; other site 290399010013 putative PBP binding loops; other site 290399010014 ABC-ATPase subunit interface; other site 290399010015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399010016 substrate binding pocket [chemical binding]; other site 290399010017 NMT1/THI5 like; Region: NMT1; pfam09084 290399010018 membrane-bound complex binding site; other site 290399010019 hinge residues; other site 290399010020 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 290399010021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399010022 amino acid transporter; Region: 2A0306; TIGR00909 290399010023 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 290399010024 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 290399010025 Protein of unknown function (DUF779); Region: DUF779; pfam05610 290399010026 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290399010027 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 290399010028 NAD binding site [chemical binding]; other site 290399010029 substrate binding site [chemical binding]; other site 290399010030 catalytic Zn binding site [ion binding]; other site 290399010031 tetramer interface [polypeptide binding]; other site 290399010032 structural Zn binding site [ion binding]; other site 290399010033 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 290399010034 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399010035 NAD(P) binding site [chemical binding]; other site 290399010036 catalytic residues [active] 290399010037 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 290399010038 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 290399010039 ferredoxin-NADP+ reductase; Region: PLN02852 290399010040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399010041 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 290399010042 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 290399010043 active site 290399010044 DNA binding site [nucleotide binding] 290399010045 Int/Topo IB signature motif; other site 290399010046 Predicted permeases [General function prediction only]; Region: RarD; COG2962 290399010047 EamA-like transporter family; Region: EamA; cl17759 290399010048 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399010049 Ligand Binding Site [chemical binding]; other site 290399010050 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399010051 Ligand Binding Site [chemical binding]; other site 290399010052 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 290399010053 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290399010054 inhibitor-cofactor binding pocket; inhibition site 290399010055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399010056 catalytic residue [active] 290399010057 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 290399010058 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 290399010059 tetrameric interface [polypeptide binding]; other site 290399010060 NAD binding site [chemical binding]; other site 290399010061 catalytic residues [active] 290399010062 substrate binding site [chemical binding]; other site 290399010063 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290399010064 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399010065 Condensation domain; Region: Condensation; pfam00668 290399010066 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290399010067 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 290399010068 acyl-activating enzyme (AAE) consensus motif; other site 290399010069 AMP binding site [chemical binding]; other site 290399010070 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290399010071 Condensation domain; Region: Condensation; pfam00668 290399010072 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 290399010073 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 290399010074 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290399010075 acyl-activating enzyme (AAE) consensus motif; other site 290399010076 AMP binding site [chemical binding]; other site 290399010077 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290399010078 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 290399010079 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 290399010080 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 290399010081 acyl-activating enzyme (AAE) consensus motif; other site 290399010082 AMP binding site [chemical binding]; other site 290399010083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 290399010084 MbtH-like protein; Region: MbtH; pfam03621 290399010085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399010086 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 290399010087 Walker A/P-loop; other site 290399010088 ATP binding site [chemical binding]; other site 290399010089 Q-loop/lid; other site 290399010090 ABC transporter signature motif; other site 290399010091 Walker B; other site 290399010092 D-loop; other site 290399010093 H-loop/switch region; other site 290399010094 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290399010095 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290399010096 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290399010097 cyanate transporter; Region: CynX; TIGR00896 290399010098 transcriptional regulator NanR; Provisional; Region: PRK03837 290399010099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399010100 DNA-binding site [nucleotide binding]; DNA binding site 290399010101 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290399010102 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290399010103 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290399010104 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290399010105 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 290399010106 hydrophobic ligand binding site; other site 290399010107 ferredoxin-NADP+ reductase; Region: PLN02852 290399010108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399010109 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 290399010110 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 290399010111 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290399010112 active site 290399010113 SAM binding site [chemical binding]; other site 290399010114 homodimer interface [polypeptide binding]; other site 290399010115 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399010116 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 290399010117 DNA-binding interface [nucleotide binding]; DNA binding site 290399010118 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 290399010119 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 290399010120 putative hydrophobic ligand binding site [chemical binding]; other site 290399010121 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 290399010122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010123 dimer interface [polypeptide binding]; other site 290399010124 conserved gate region; other site 290399010125 putative PBP binding loops; other site 290399010126 ABC-ATPase subunit interface; other site 290399010127 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 290399010128 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 290399010129 Walker A/P-loop; other site 290399010130 ATP binding site [chemical binding]; other site 290399010131 Q-loop/lid; other site 290399010132 ABC transporter signature motif; other site 290399010133 Walker B; other site 290399010134 D-loop; other site 290399010135 H-loop/switch region; other site 290399010136 NMT1-like family; Region: NMT1_2; pfam13379 290399010137 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 290399010138 hypothetical protein; Provisional; Region: PRK06062 290399010139 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290399010140 inhibitor-cofactor binding pocket; inhibition site 290399010141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399010142 catalytic residue [active] 290399010143 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 290399010144 hypothetical protein; Reviewed; Region: PRK09588 290399010145 uncertain number of G/C homopolymer repeats 290399010146 GYD domain; Region: GYD; pfam08734 290399010147 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 290399010148 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 290399010149 CysD dimerization site [polypeptide binding]; other site 290399010150 G1 box; other site 290399010151 putative GEF interaction site [polypeptide binding]; other site 290399010152 GTP/Mg2+ binding site [chemical binding]; other site 290399010153 Switch I region; other site 290399010154 G2 box; other site 290399010155 G3 box; other site 290399010156 Switch II region; other site 290399010157 G4 box; other site 290399010158 G5 box; other site 290399010159 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 290399010160 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 290399010161 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 290399010162 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290399010163 Active Sites [active] 290399010164 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 290399010165 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 290399010166 Active Sites [active] 290399010167 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 290399010168 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290399010169 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290399010170 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 290399010171 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 290399010172 putative active site [active] 290399010173 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 290399010174 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 290399010175 putative active site [active] 290399010176 Predicted membrane protein [Function unknown]; Region: COG2860 290399010177 UPF0126 domain; Region: UPF0126; pfam03458 290399010178 UPF0126 domain; Region: UPF0126; pfam03458 290399010179 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290399010180 putative active site [active] 290399010181 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290399010182 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290399010183 substrate binding pocket [chemical binding]; other site 290399010184 chain length determination region; other site 290399010185 substrate-Mg2+ binding site; other site 290399010186 catalytic residues [active] 290399010187 aspartate-rich region 1; other site 290399010188 active site lid residues [active] 290399010189 aspartate-rich region 2; other site 290399010190 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290399010191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399010192 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 290399010193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399010194 S-adenosylmethionine binding site [chemical binding]; other site 290399010195 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290399010196 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290399010197 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399010198 substrate binding pocket [chemical binding]; other site 290399010199 membrane-bound complex binding site; other site 290399010200 hinge residues; other site 290399010201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010202 dimer interface [polypeptide binding]; other site 290399010203 conserved gate region; other site 290399010204 putative PBP binding loops; other site 290399010205 ABC-ATPase subunit interface; other site 290399010206 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399010207 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290399010208 Walker A/P-loop; other site 290399010209 ATP binding site [chemical binding]; other site 290399010210 Q-loop/lid; other site 290399010211 ABC transporter signature motif; other site 290399010212 Walker B; other site 290399010213 D-loop; other site 290399010214 H-loop/switch region; other site 290399010215 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290399010216 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 290399010217 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 290399010218 dimer interface [polypeptide binding]; other site 290399010219 tetramer interface [polypeptide binding]; other site 290399010220 PYR/PP interface [polypeptide binding]; other site 290399010221 TPP binding site [chemical binding]; other site 290399010222 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 290399010223 TPP-binding site; other site 290399010224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399010225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399010226 DNA binding site [nucleotide binding] 290399010227 domain linker motif; other site 290399010228 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 290399010229 putative dimerization interface [polypeptide binding]; other site 290399010230 putative ligand binding site [chemical binding]; other site 290399010231 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 290399010232 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290399010233 substrate binding [chemical binding]; other site 290399010234 active site 290399010235 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399010236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010237 dimer interface [polypeptide binding]; other site 290399010238 conserved gate region; other site 290399010239 putative PBP binding loops; other site 290399010240 ABC-ATPase subunit interface; other site 290399010241 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399010242 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 290399010243 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010244 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010245 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010246 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399010247 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399010248 DNA binding site [nucleotide binding] 290399010249 domain linker motif; other site 290399010250 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399010251 dimerization interface [polypeptide binding]; other site 290399010252 ligand binding site [chemical binding]; other site 290399010253 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010254 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010255 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 290399010256 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290399010257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290399010258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010259 dimer interface [polypeptide binding]; other site 290399010260 putative PBP binding loops; other site 290399010261 ABC-ATPase subunit interface; other site 290399010262 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399010263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010264 dimer interface [polypeptide binding]; other site 290399010265 conserved gate region; other site 290399010266 putative PBP binding loops; other site 290399010267 ABC-ATPase subunit interface; other site 290399010268 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290399010269 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290399010270 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 290399010271 Putative glucoamylase; Region: Glycoamylase; pfam10091 290399010272 arginine-tRNA ligase; Region: PLN02286 290399010273 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 290399010274 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290399010275 active site 290399010276 HIGH motif; other site 290399010277 KMSK motif region; other site 290399010278 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 290399010279 tRNA binding surface [nucleotide binding]; other site 290399010280 anticodon binding site; other site 290399010281 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 290399010282 O-succinylbenzoate synthase; Provisional; Region: PRK02901 290399010283 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 290399010284 active site 290399010285 PAP2 superfamily; Region: PAP2; pfam01569 290399010286 active site 290399010287 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 290399010288 aspartate aminotransferase; Provisional; Region: PRK06836 290399010289 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399010290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399010291 homodimer interface [polypeptide binding]; other site 290399010292 catalytic residue [active] 290399010293 DNA binding site [nucleotide binding] 290399010294 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 290399010295 Bacterial transcriptional activator domain; Region: BTAD; smart01043 290399010296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399010297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399010298 active site 290399010299 phosphorylation site [posttranslational modification] 290399010300 intermolecular recognition site; other site 290399010301 dimerization interface [polypeptide binding]; other site 290399010302 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290399010303 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 290399010304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399010305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399010306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399010307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399010308 putative substrate translocation pore; other site 290399010309 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 290399010310 S-layer homology domain; Region: SLH; pfam00395 290399010311 S-layer homology domain; Region: SLH; pfam00395 290399010312 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 290399010313 S-layer homology domain; Region: SLH; pfam00395 290399010314 S-layer homology domain; Region: SLH; pfam00395 290399010315 S-layer homology domain; Region: SLH; pfam00395 290399010316 Fn3 associated; Region: Fn3_assoc; pfam13287 290399010317 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 290399010318 S-layer homology domain; Region: SLH; pfam00395 290399010319 S-layer homology domain; Region: SLH; pfam00395 290399010320 S-layer homology domain; Region: SLH; pfam00395 290399010321 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399010322 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399010323 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399010324 S-layer homology domain; Region: SLH; pfam00395 290399010325 S-layer homology domain; Region: SLH; pfam00395 290399010326 GAF domain; Region: GAF; pfam01590 290399010327 GAF domain; Region: GAF_2; pfam13185 290399010328 ANTAR domain; Region: ANTAR; pfam03861 290399010329 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290399010330 GAF domain; Region: GAF; pfam01590 290399010331 ANTAR domain; Region: ANTAR; pfam03861 290399010332 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 290399010333 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399010334 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290399010335 GAF domain; Region: GAF; cl17456 290399010336 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399010337 tetracycline repressor protein TetR; Provisional; Region: PRK13756 290399010338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399010339 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 290399010340 MarR family; Region: MarR_2; pfam12802 290399010341 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 290399010342 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399010343 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399010344 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399010345 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399010346 S-layer homology domain; Region: SLH; pfam00395 290399010347 S-layer homology domain; Region: SLH; pfam00395 290399010348 S-layer homology domain; Region: SLH; pfam00395 290399010349 O-Antigen ligase; Region: Wzy_C; pfam04932 290399010350 Tetratricopeptide repeat; Region: TPR_16; pfam13432 290399010351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290399010352 TPR motif; other site 290399010353 binding surface 290399010354 methylenetetrahydrofolate reductase; Region: PLN02540 290399010355 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 290399010356 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 290399010357 active site 290399010358 catalytic triad [active] 290399010359 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 290399010360 S-layer homology domain; Region: SLH; pfam00395 290399010361 S-layer homology domain; Region: SLH; pfam00395 290399010362 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 290399010363 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290399010364 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290399010365 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290399010366 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290399010367 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290399010368 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290399010369 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 290399010370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290399010371 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 290399010372 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 290399010373 active site 290399010374 catalytic triad [active] 290399010375 oxyanion hole [active] 290399010376 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290399010377 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 290399010378 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 290399010379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290399010380 E3 interaction surface; other site 290399010381 lipoyl attachment site [posttranslational modification]; other site 290399010382 e3 binding domain; Region: E3_binding; pfam02817 290399010383 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290399010384 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290399010385 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290399010386 alpha subunit interface [polypeptide binding]; other site 290399010387 TPP binding site [chemical binding]; other site 290399010388 heterodimer interface [polypeptide binding]; other site 290399010389 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399010390 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290399010391 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290399010392 tetramer interface [polypeptide binding]; other site 290399010393 TPP-binding site [chemical binding]; other site 290399010394 heterodimer interface [polypeptide binding]; other site 290399010395 phosphorylation loop region [posttranslational modification] 290399010396 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399010397 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290399010398 putative DNA binding site [nucleotide binding]; other site 290399010399 putative Zn2+ binding site [ion binding]; other site 290399010400 AsnC family; Region: AsnC_trans_reg; pfam01037 290399010401 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 290399010402 Chain length determinant protein; Region: Wzz; pfam02706 290399010403 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290399010404 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399010405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290399010406 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290399010407 Probable Catalytic site; other site 290399010408 metal-binding site 290399010409 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 290399010410 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290399010411 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290399010412 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 290399010413 Probable Catalytic site; other site 290399010414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399010415 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290399010416 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 290399010417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399010418 putative ADP-binding pocket [chemical binding]; other site 290399010419 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290399010420 Bacterial sugar transferase; Region: Bac_transf; pfam02397 290399010421 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290399010422 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399010423 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290399010424 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 290399010425 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 290399010426 VanZ like family; Region: VanZ; cl01971 290399010427 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 290399010428 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290399010429 active site 290399010430 tetramer interface; other site 290399010431 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 290399010432 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399010433 substrate binding site [chemical binding]; other site 290399010434 oxyanion hole (OAH) forming residues; other site 290399010435 trimer interface [polypeptide binding]; other site 290399010436 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 290399010437 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 290399010438 FAD binding pocket [chemical binding]; other site 290399010439 FAD binding motif [chemical binding]; other site 290399010440 phosphate binding motif [ion binding]; other site 290399010441 beta-alpha-beta structure motif; other site 290399010442 NAD(p) ribose binding residues [chemical binding]; other site 290399010443 NAD binding pocket [chemical binding]; other site 290399010444 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 290399010445 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290399010446 catalytic loop [active] 290399010447 iron binding site [ion binding]; other site 290399010448 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 290399010449 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 290399010450 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 290399010451 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 290399010452 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 290399010453 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 290399010454 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290399010455 dimer interface [polypeptide binding]; other site 290399010456 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 290399010457 Chain length determinant protein; Region: Wzz; cl15801 290399010458 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290399010459 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290399010460 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 290399010461 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 290399010462 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290399010463 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399010464 active site 290399010465 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290399010466 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290399010467 active site 290399010468 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 290399010469 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 290399010470 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290399010471 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 290399010472 putative active site [active] 290399010473 putative metal binding site [ion binding]; other site 290399010474 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290399010475 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 290399010476 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290399010477 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290399010478 Hemerythrin family; Region: Hemerythrin-like; cl15774 290399010479 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 290399010480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290399010481 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 290399010482 propionate/acetate kinase; Provisional; Region: PRK12379 290399010483 phosphate acetyltransferase; Reviewed; Region: PRK05632 290399010484 DRTGG domain; Region: DRTGG; pfam07085 290399010485 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 290399010486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399010487 salt bridge; other site 290399010488 non-specific DNA binding site [nucleotide binding]; other site 290399010489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290399010490 sequence-specific DNA binding site [nucleotide binding]; other site 290399010491 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 290399010492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399010493 putative substrate translocation pore; other site 290399010494 PAS fold; Region: PAS_3; pfam08447 290399010495 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399010496 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 290399010497 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290399010498 CoenzymeA binding site [chemical binding]; other site 290399010499 subunit interaction site [polypeptide binding]; other site 290399010500 PHB binding site; other site 290399010501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399010502 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 290399010503 acyl-activating enzyme (AAE) consensus motif; other site 290399010504 AMP binding site [chemical binding]; other site 290399010505 active site 290399010506 CoA binding site [chemical binding]; other site 290399010507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399010508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399010509 Domain of unknown function (DUF427); Region: DUF427; pfam04248 290399010510 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399010511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399010512 active site 290399010513 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 290399010514 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 290399010515 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 290399010516 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 290399010517 substrate binding site [chemical binding]; other site 290399010518 dimer interface [polypeptide binding]; other site 290399010519 NADP binding site [chemical binding]; other site 290399010520 catalytic residues [active] 290399010521 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 290399010522 active site 2 [active] 290399010523 active site 1 [active] 290399010524 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290399010525 CoenzymeA binding site [chemical binding]; other site 290399010526 subunit interaction site [polypeptide binding]; other site 290399010527 PHB binding site; other site 290399010528 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 290399010529 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 290399010530 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290399010531 Ferritin-like domain; Region: Ferritin; pfam00210 290399010532 ferroxidase diiron center [ion binding]; other site 290399010533 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290399010534 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399010535 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399010536 DNA binding residues [nucleotide binding] 290399010537 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290399010538 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 290399010539 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 290399010540 active site 290399010541 catalytic triad [active] 290399010542 oxyanion hole [active] 290399010543 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 290399010544 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 290399010545 putative hydrophobic ligand binding site [chemical binding]; other site 290399010546 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 290399010547 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 290399010548 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 290399010549 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290399010550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399010551 substrate binding site [chemical binding]; other site 290399010552 oxyanion hole (OAH) forming residues; other site 290399010553 trimer interface [polypeptide binding]; other site 290399010554 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 290399010555 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290399010556 dimer interface [polypeptide binding]; other site 290399010557 active site 290399010558 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290399010559 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290399010560 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290399010561 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 290399010562 hydrophobic ligand binding site; other site 290399010563 CsbD-like; Region: CsbD; pfam05532 290399010564 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 290399010565 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 290399010566 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 290399010567 iron-sulfur cluster [ion binding]; other site 290399010568 [2Fe-2S] cluster binding site [ion binding]; other site 290399010569 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 290399010570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399010571 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290399010572 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290399010573 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290399010574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399010575 Walker A/P-loop; other site 290399010576 ATP binding site [chemical binding]; other site 290399010577 Q-loop/lid; other site 290399010578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399010579 ABC transporter; Region: ABC_tran_2; pfam12848 290399010580 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399010581 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290399010582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290399010583 ABC-ATPase subunit interface; other site 290399010584 dimer interface [polypeptide binding]; other site 290399010585 putative PBP binding regions; other site 290399010586 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290399010587 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290399010588 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 290399010589 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290399010590 metal binding site [ion binding]; metal-binding site 290399010591 CAAX protease self-immunity; Region: Abi; pfam02517 290399010592 active site 290399010593 metal binding site [ion binding]; metal-binding site 290399010594 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 290399010595 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290399010596 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290399010597 substrate binding site [chemical binding]; other site 290399010598 oxyanion hole (OAH) forming residues; other site 290399010599 trimer interface [polypeptide binding]; other site 290399010600 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399010601 acyl-activating enzyme (AAE) consensus motif; other site 290399010602 AMP binding site [chemical binding]; other site 290399010603 active site 290399010604 CoA binding site [chemical binding]; other site 290399010605 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 290399010606 UbiA prenyltransferase family; Region: UbiA; pfam01040 290399010607 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 290399010608 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 290399010609 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290399010610 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 290399010611 ResB-like family; Region: ResB; pfam05140 290399010612 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290399010613 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290399010614 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 290399010615 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290399010616 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290399010617 catalytic residues [active] 290399010618 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399010619 catalytic core [active] 290399010620 Uncharacterized conserved protein [Function unknown]; Region: COG2353 290399010621 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 290399010622 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 290399010623 CoA binding domain; Region: CoA_binding; smart00881 290399010624 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 290399010625 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 290399010626 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290399010627 DNA binding domain, excisionase family; Region: excise; TIGR01764 290399010628 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 290399010629 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290399010630 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 290399010631 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 290399010632 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 290399010633 N- and C-terminal domain interface [polypeptide binding]; other site 290399010634 active site 290399010635 putative catalytic site [active] 290399010636 metal binding site [ion binding]; metal-binding site 290399010637 ATP binding site [chemical binding]; other site 290399010638 carbohydrate binding site [chemical binding]; other site 290399010639 short chain dehydrogenase; Validated; Region: PRK08324 290399010640 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 290399010641 intersubunit interface [polypeptide binding]; other site 290399010642 active site 290399010643 Zn2+ binding site [ion binding]; other site 290399010644 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 290399010645 putative NAD(P) binding site [chemical binding]; other site 290399010646 active site 290399010647 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 290399010648 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 290399010649 Domain of unknown function (DUF718); Region: DUF718; pfam05336 290399010650 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399010651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399010652 DNA binding site [nucleotide binding] 290399010653 domain linker motif; other site 290399010654 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399010655 dimerization interface [polypeptide binding]; other site 290399010656 ligand binding site [chemical binding]; other site 290399010657 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399010658 short chain dehydrogenase; Provisional; Region: PRK06180 290399010659 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 290399010660 NADP binding site [chemical binding]; other site 290399010661 active site 290399010662 steroid binding site; other site 290399010663 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399010664 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399010665 active site 290399010666 catalytic tetrad [active] 290399010667 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 290399010668 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 290399010669 active site 290399010670 catalytic triad [active] 290399010671 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399010672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010673 dimer interface [polypeptide binding]; other site 290399010674 conserved gate region; other site 290399010675 putative PBP binding loops; other site 290399010676 ABC-ATPase subunit interface; other site 290399010677 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399010678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010679 dimer interface [polypeptide binding]; other site 290399010680 conserved gate region; other site 290399010681 ABC-ATPase subunit interface; other site 290399010682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010683 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010684 Protein of unknown function, DUF624; Region: DUF624; cl02369 290399010685 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399010686 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399010687 Methane oxygenase PmoA; Region: PmoA; pfam14100 290399010688 Transmembrane secretion effector; Region: MFS_3; pfam05977 290399010689 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399010690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010691 dimer interface [polypeptide binding]; other site 290399010692 conserved gate region; other site 290399010693 putative PBP binding loops; other site 290399010694 ABC-ATPase subunit interface; other site 290399010695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290399010696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010697 dimer interface [polypeptide binding]; other site 290399010698 putative PBP binding loops; other site 290399010699 ABC-ATPase subunit interface; other site 290399010700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010702 uncertain number of G/C homopolymer repeats 290399010703 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 290399010704 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 290399010705 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 290399010706 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 290399010707 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010708 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010709 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399010710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010711 dimer interface [polypeptide binding]; other site 290399010712 conserved gate region; other site 290399010713 putative PBP binding loops; other site 290399010714 ABC-ATPase subunit interface; other site 290399010715 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 290399010716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010717 dimer interface [polypeptide binding]; other site 290399010718 putative PBP binding loops; other site 290399010719 ABC-ATPase subunit interface; other site 290399010720 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010722 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 290399010723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399010724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399010725 Methane oxygenase PmoA; Region: PmoA; pfam14100 290399010726 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290399010727 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 290399010728 active site 290399010729 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 290399010730 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290399010731 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290399010732 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 290399010733 active site clefts [active] 290399010734 zinc binding site [ion binding]; other site 290399010735 dimer interface [polypeptide binding]; other site 290399010736 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 290399010737 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 290399010738 dimer interface [polypeptide binding]; other site 290399010739 NADP binding site [chemical binding]; other site 290399010740 catalytic residues [active] 290399010741 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 290399010742 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 290399010743 active site pocket [active] 290399010744 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 290399010745 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 290399010746 catalytic residue [active] 290399010747 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399010748 extended (e) SDRs; Region: SDR_e; cd08946 290399010749 NAD(P) binding site [chemical binding]; other site 290399010750 active site 290399010751 substrate binding site [chemical binding]; other site 290399010752 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399010753 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399010754 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399010755 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399010756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399010757 DNA binding site [nucleotide binding] 290399010758 domain linker motif; other site 290399010759 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399010760 dimerization interface [polypeptide binding]; other site 290399010761 ligand binding site [chemical binding]; other site 290399010762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399010763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399010764 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399010765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399010766 DNA-binding site [nucleotide binding]; DNA binding site 290399010767 FCD domain; Region: FCD; pfam07729 290399010768 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 290399010769 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290399010770 phosphate binding site [ion binding]; other site 290399010771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399010772 dimerization interface [polypeptide binding]; other site 290399010773 putative DNA binding site [nucleotide binding]; other site 290399010774 putative Zn2+ binding site [ion binding]; other site 290399010775 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 290399010776 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 290399010777 active site 290399010778 Zn binding site [ion binding]; other site 290399010779 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 290399010780 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 290399010781 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 290399010782 TrkA-N domain; Region: TrkA_N; pfam02254 290399010783 TrkA-C domain; Region: TrkA_C; pfam02080 290399010784 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 290399010785 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 290399010786 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 290399010787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399010788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399010789 DNA binding residues [nucleotide binding] 290399010790 YCII-related domain; Region: YCII; cl00999 290399010791 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290399010792 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290399010793 DNA interaction; other site 290399010794 Metal-binding active site; metal-binding site 290399010795 exopolyphosphatase; Region: exo_poly_only; TIGR03706 290399010796 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290399010797 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290399010798 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290399010799 putative active site [active] 290399010800 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 290399010801 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 290399010802 active site 290399010803 interdomain interaction site; other site 290399010804 putative metal-binding site [ion binding]; other site 290399010805 nucleotide binding site [chemical binding]; other site 290399010806 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 290399010807 domain I; other site 290399010808 phosphate binding site [ion binding]; other site 290399010809 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290399010810 domain II; other site 290399010811 domain III; other site 290399010812 nucleotide binding site [chemical binding]; other site 290399010813 DNA binding groove [nucleotide binding] 290399010814 catalytic site [active] 290399010815 domain IV; other site 290399010816 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290399010817 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 290399010818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399010819 dimerization interface [polypeptide binding]; other site 290399010820 putative DNA binding site [nucleotide binding]; other site 290399010821 putative Zn2+ binding site [ion binding]; other site 290399010822 H+ Antiporter protein; Region: 2A0121; TIGR00900 290399010823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399010824 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 290399010825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399010826 S-adenosylmethionine binding site [chemical binding]; other site 290399010827 LabA_like proteins; Region: LabA_like; cd06167 290399010828 putative metal binding site [ion binding]; other site 290399010829 Uncharacterized conserved protein [Function unknown]; Region: COG1432 290399010830 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290399010831 active site 290399010832 dimer interface [polypeptide binding]; other site 290399010833 motif 2; other site 290399010834 motif 3; other site 290399010835 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 290399010836 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 290399010837 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 290399010838 active site residue [active] 290399010839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399010840 Coenzyme A binding pocket [chemical binding]; other site 290399010841 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 290399010842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399010843 ATP binding site [chemical binding]; other site 290399010844 putative Mg++ binding site [ion binding]; other site 290399010845 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290399010846 ATP-binding site [chemical binding]; other site 290399010847 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 290399010848 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 290399010849 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 290399010850 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 290399010851 Type II/IV secretion system protein; Region: T2SE; pfam00437 290399010852 Walker A motif; other site 290399010853 ATP binding site [chemical binding]; other site 290399010854 Walker B motif; other site 290399010855 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 290399010856 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 290399010857 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 290399010858 active site 290399010859 DNA binding site [nucleotide binding] 290399010860 catalytic site [active] 290399010861 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290399010862 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 290399010863 putative active site [active] 290399010864 putative CoA binding site [chemical binding]; other site 290399010865 nudix motif; other site 290399010866 metal binding site [ion binding]; metal-binding site 290399010867 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 290399010868 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290399010869 minor groove reading motif; other site 290399010870 helix-hairpin-helix signature motif; other site 290399010871 substrate binding pocket [chemical binding]; other site 290399010872 active site 290399010873 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 290399010874 acetyl-CoA synthetase; Provisional; Region: PRK00174 290399010875 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290399010876 active site 290399010877 CoA binding site [chemical binding]; other site 290399010878 acyl-activating enzyme (AAE) consensus motif; other site 290399010879 AMP binding site [chemical binding]; other site 290399010880 acetate binding site [chemical binding]; other site 290399010881 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010882 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010884 dimer interface [polypeptide binding]; other site 290399010885 conserved gate region; other site 290399010886 putative PBP binding loops; other site 290399010887 ABC-ATPase subunit interface; other site 290399010888 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399010889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010890 dimer interface [polypeptide binding]; other site 290399010891 conserved gate region; other site 290399010892 putative PBP binding loops; other site 290399010893 ABC-ATPase subunit interface; other site 290399010894 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290399010895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399010896 DNA-binding site [nucleotide binding]; DNA binding site 290399010897 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290399010898 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399010899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399010900 DNA binding site [nucleotide binding] 290399010901 domain linker motif; other site 290399010902 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399010903 dimerization interface [polypeptide binding]; other site 290399010904 ligand binding site [chemical binding]; other site 290399010905 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399010906 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399010907 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 290399010908 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399010909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399010910 dimer interface [polypeptide binding]; other site 290399010911 conserved gate region; other site 290399010912 putative PBP binding loops; other site 290399010913 ABC-ATPase subunit interface; other site 290399010914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399010915 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399010916 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 290399010917 Melibiase; Region: Melibiase; pfam02065 290399010918 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 290399010919 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 290399010920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399010921 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290399010922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399010923 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 290399010924 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 290399010925 Dehydroquinase class II; Region: DHquinase_II; pfam01220 290399010926 active site 290399010927 trimer interface [polypeptide binding]; other site 290399010928 dimer interface [polypeptide binding]; other site 290399010929 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 290399010930 Colicin V production protein; Region: Colicin_V; pfam02674 290399010931 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 290399010932 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290399010933 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 290399010934 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290399010935 ligand binding site [chemical binding]; other site 290399010936 flexible hinge region; other site 290399010937 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 290399010938 putative switch regulator; other site 290399010939 non-specific DNA interactions [nucleotide binding]; other site 290399010940 DNA binding site [nucleotide binding] 290399010941 sequence specific DNA binding site [nucleotide binding]; other site 290399010942 putative cAMP binding site [chemical binding]; other site 290399010943 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290399010944 homotrimer interaction site [polypeptide binding]; other site 290399010945 putative active site [active] 290399010946 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 290399010947 Transglycosylase; Region: Transgly; pfam00912 290399010948 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290399010949 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290399010950 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 290399010951 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290399010952 putative active site [active] 290399010953 putative metal binding site [ion binding]; other site 290399010954 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399010955 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399010956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399010957 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399010958 Walker A/P-loop; other site 290399010959 ATP binding site [chemical binding]; other site 290399010960 Q-loop/lid; other site 290399010961 ABC transporter signature motif; other site 290399010962 Walker B; other site 290399010963 D-loop; other site 290399010964 H-loop/switch region; other site 290399010965 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399010966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399010967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399010968 Walker A/P-loop; other site 290399010969 ATP binding site [chemical binding]; other site 290399010970 Q-loop/lid; other site 290399010971 ABC transporter signature motif; other site 290399010972 Walker B; other site 290399010973 D-loop; other site 290399010974 H-loop/switch region; other site 290399010975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290399010976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399010977 non-specific DNA binding site [nucleotide binding]; other site 290399010978 salt bridge; other site 290399010979 sequence-specific DNA binding site [nucleotide binding]; other site 290399010980 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 290399010981 ATP binding site [chemical binding]; other site 290399010982 active site 290399010983 substrate binding site [chemical binding]; other site 290399010984 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 290399010985 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290399010986 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 290399010987 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 290399010988 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 290399010989 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 290399010990 Moco binding site; other site 290399010991 metal coordination site [ion binding]; other site 290399010992 L-asparaginase II; Region: Asparaginase_II; pfam06089 290399010993 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290399010994 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290399010995 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290399010996 classical (c) SDRs; Region: SDR_c; cd05233 290399010997 NAD(P) binding site [chemical binding]; other site 290399010998 active site 290399010999 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290399011000 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 290399011001 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 290399011002 Na binding site [ion binding]; other site 290399011003 putative substrate binding site [chemical binding]; other site 290399011004 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 290399011005 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 290399011006 dimer interface [polypeptide binding]; other site 290399011007 TPP-binding site [chemical binding]; other site 290399011008 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 290399011009 metal-binding site 290399011010 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 290399011011 ligand binding site [chemical binding]; other site 290399011012 active site 290399011013 Protein of unknown function, DUF488; Region: DUF488; pfam04343 290399011014 HEAT repeats; Region: HEAT_2; pfam13646 290399011015 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399011016 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399011017 active site 290399011018 catalytic tetrad [active] 290399011019 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 290399011020 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 290399011021 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 290399011022 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 290399011023 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 290399011024 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 290399011025 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 290399011026 XdhC Rossmann domain; Region: XdhC_C; pfam13478 290399011027 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290399011028 benzoate transporter; Region: benE; TIGR00843 290399011029 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290399011030 nucleoside/Zn binding site; other site 290399011031 dimer interface [polypeptide binding]; other site 290399011032 catalytic motif [active] 290399011033 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 290399011034 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 290399011035 active site 290399011036 putative substrate binding pocket [chemical binding]; other site 290399011037 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 290399011038 nucleotide binding site [chemical binding]; other site 290399011039 urate oxidase; Region: urate_oxi; TIGR03383 290399011040 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290399011041 active site 290399011042 xanthine permease; Region: pbuX; TIGR03173 290399011043 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290399011044 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290399011045 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 290399011046 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 290399011047 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 290399011048 Na binding site [ion binding]; other site 290399011049 putative substrate binding site [chemical binding]; other site 290399011050 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290399011051 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399011052 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399011053 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 290399011054 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290399011055 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 290399011056 putative NAD(P) binding site [chemical binding]; other site 290399011057 malate synthase A; Region: malate_syn_A; TIGR01344 290399011058 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 290399011059 active site 290399011060 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 290399011061 hypothetical protein; Provisional; Region: PRK11171 290399011062 Cupin domain; Region: Cupin_2; pfam07883 290399011063 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290399011064 Beta-lactamase; Region: Beta-lactamase; pfam00144 290399011065 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 290399011066 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399011067 NAD binding site [chemical binding]; other site 290399011068 catalytic Zn binding site [ion binding]; other site 290399011069 structural Zn binding site [ion binding]; other site 290399011070 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290399011071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399011072 active site 290399011073 motif I; other site 290399011074 motif II; other site 290399011075 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 290399011076 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290399011077 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290399011078 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290399011079 Protein of unknown function DUF72; Region: DUF72; pfam01904 290399011080 Uncharacterized conserved protein [Function unknown]; Region: COG4850 290399011081 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 290399011082 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 290399011083 beta-galactosidase; Region: BGL; TIGR03356 290399011084 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290399011085 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290399011086 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290399011087 putative dimer interface [polypeptide binding]; other site 290399011088 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290399011089 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290399011090 DNA binding residues [nucleotide binding] 290399011091 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 290399011092 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 290399011093 active site 290399011094 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 290399011095 LabA_like proteins; Region: LabA_like; cd06167 290399011096 putative metal binding site [ion binding]; other site 290399011097 Uncharacterized conserved protein [Function unknown]; Region: COG1432 290399011098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399011099 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 290399011100 active site 290399011101 catalytic tetrad [active] 290399011102 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399011103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399011104 NAD(P) binding site [chemical binding]; other site 290399011105 active site 290399011106 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 290399011107 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399011108 Ligand Binding Site [chemical binding]; other site 290399011109 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399011110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399011111 active site 290399011112 phosphorylation site [posttranslational modification] 290399011113 intermolecular recognition site; other site 290399011114 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 290399011115 DNA binding residues [nucleotide binding] 290399011116 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290399011117 GAF domain; Region: GAF; pfam01590 290399011118 Histidine kinase; Region: HisKA_3; pfam07730 290399011119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290399011120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399011121 ATP binding site [chemical binding]; other site 290399011122 Mg2+ binding site [ion binding]; other site 290399011123 G-X-G motif; other site 290399011124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399011125 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 290399011126 putative ADP-binding pocket [chemical binding]; other site 290399011127 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399011128 active site 290399011129 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 290399011130 GAF domain; Region: GAF; pfam01590 290399011131 GAF domain; Region: GAF_2; pfam13185 290399011132 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399011133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399011134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399011135 DNA binding site [nucleotide binding] 290399011136 domain linker motif; other site 290399011137 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399011138 dimerization interface [polypeptide binding]; other site 290399011139 ligand binding site [chemical binding]; other site 290399011140 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290399011141 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290399011142 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290399011143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399011144 dimer interface [polypeptide binding]; other site 290399011145 conserved gate region; other site 290399011146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 290399011147 ABC-ATPase subunit interface; other site 290399011148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399011149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399011150 dimer interface [polypeptide binding]; other site 290399011151 conserved gate region; other site 290399011152 putative PBP binding loops; other site 290399011153 ABC-ATPase subunit interface; other site 290399011154 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 290399011155 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399011156 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399011157 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399011158 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290399011159 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399011160 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399011161 CsbD-like; Region: CsbD; cl17424 290399011162 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 290399011163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399011164 Walker A/P-loop; other site 290399011165 ATP binding site [chemical binding]; other site 290399011166 Q-loop/lid; other site 290399011167 ABC transporter signature motif; other site 290399011168 Walker B; other site 290399011169 D-loop; other site 290399011170 H-loop/switch region; other site 290399011171 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 290399011172 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 290399011173 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 290399011174 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 290399011175 putative active site [active] 290399011176 putative metal binding site [ion binding]; other site 290399011177 CAAX protease self-immunity; Region: Abi; pfam02517 290399011178 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 290399011179 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 290399011180 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399011181 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290399011182 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399011183 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290399011184 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 290399011185 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 290399011186 active site 290399011187 catalytic triad [active] 290399011188 hypothetical protein; Provisional; Region: PRK12839 290399011189 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 290399011190 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290399011191 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 290399011192 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 290399011193 active site 290399011194 FMN binding site [chemical binding]; other site 290399011195 substrate binding site [chemical binding]; other site 290399011196 putative catalytic residue [active] 290399011197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399011198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399011199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399011200 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399011201 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399011202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399011203 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399011204 putative substrate translocation pore; other site 290399011205 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399011206 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399011207 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399011208 intracellular protease, PfpI family; Region: PfpI; TIGR01382 290399011209 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 290399011210 proposed catalytic triad [active] 290399011211 conserved cys residue [active] 290399011212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399011213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399011214 active site 290399011215 phosphorylation site [posttranslational modification] 290399011216 intermolecular recognition site; other site 290399011217 dimerization interface [polypeptide binding]; other site 290399011218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399011219 DNA binding residues [nucleotide binding] 290399011220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290399011221 Histidine kinase; Region: HisKA_3; pfam07730 290399011222 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399011223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399011224 DNA binding site [nucleotide binding] 290399011225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399011226 Response regulator receiver domain; Region: Response_reg; pfam00072 290399011227 active site 290399011228 phosphorylation site [posttranslational modification] 290399011229 intermolecular recognition site; other site 290399011230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399011231 ATP binding site [chemical binding]; other site 290399011232 Mg2+ binding site [ion binding]; other site 290399011233 G-X-G motif; other site 290399011234 LssY C-terminus; Region: LssY_C; pfam14067 290399011235 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 290399011236 threonine dehydratase; Provisional; Region: PRK08246 290399011237 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290399011238 catalytic residue [active] 290399011239 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 290399011240 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290399011241 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399011242 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 290399011243 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290399011244 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290399011245 NAD(P) binding site [chemical binding]; other site 290399011246 shikimate binding site; other site 290399011247 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399011248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399011249 putative substrate translocation pore; other site 290399011250 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 290399011251 hydrophobic ligand binding site; other site 290399011252 tyramine oxidase; Provisional; Region: tynA; PRK11504 290399011253 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 290399011254 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 290399011255 TetR family transcriptional regulator; Provisional; Region: PRK14996 290399011256 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399011257 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 290399011258 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 290399011259 Cupin domain; Region: Cupin_2; cl17218 290399011260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399011261 glutamate dehydrogenase; Provisional; Region: PRK09414 290399011262 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 290399011263 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 290399011264 NAD(P) binding site [chemical binding]; other site 290399011265 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 290399011266 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 290399011267 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399011268 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290399011269 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 290399011270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399011271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399011272 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399011273 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 290399011274 NAD(P) binding site [chemical binding]; other site 290399011275 catalytic residues [active] 290399011276 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290399011277 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 290399011278 active site 290399011279 trimer interface [polypeptide binding]; other site 290399011280 allosteric site; other site 290399011281 active site lid [active] 290399011282 hexamer (dimer of trimers) interface [polypeptide binding]; other site 290399011283 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 290399011284 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399011285 active site 290399011286 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 290399011287 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 290399011288 active site turn [active] 290399011289 phosphorylation site [posttranslational modification] 290399011290 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 290399011291 HPr interaction site; other site 290399011292 glycerol kinase (GK) interaction site [polypeptide binding]; other site 290399011293 active site 290399011294 phosphorylation site [posttranslational modification] 290399011295 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 290399011296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399011297 DNA-binding site [nucleotide binding]; DNA binding site 290399011298 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 290399011299 prephenate dehydratase; Provisional; Region: PRK11899 290399011300 Prephenate dehydratase; Region: PDT; pfam00800 290399011301 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290399011302 putative L-Phe binding site [chemical binding]; other site 290399011303 phenol 2-monooxygenase; Provisional; Region: PRK08294 290399011304 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399011305 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 290399011306 dimer interface [polypeptide binding]; other site 290399011307 hypothetical protein; Provisional; Region: PRK12764 290399011308 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290399011309 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 290399011310 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399011311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399011312 DNA-binding site [nucleotide binding]; DNA binding site 290399011313 FCD domain; Region: FCD; pfam07729 290399011314 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 290399011315 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 290399011316 NAD binding site [chemical binding]; other site 290399011317 catalytic residues [active] 290399011318 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 290399011319 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 290399011320 tetramer interface [polypeptide binding]; other site 290399011321 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 290399011322 tetramer interface [polypeptide binding]; other site 290399011323 active site 290399011324 metal binding site [ion binding]; metal-binding site 290399011325 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 290399011326 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 290399011327 Transglycosylase; Region: Transgly; pfam00912 290399011328 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290399011329 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290399011330 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399011331 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399011332 DNA-binding site [nucleotide binding]; DNA binding site 290399011333 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290399011334 AAA domain; Region: AAA_33; pfam13671 290399011335 ATP-binding site [chemical binding]; other site 290399011336 Gluconate-6-phosphate binding site [chemical binding]; other site 290399011337 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 290399011338 fructuronate transporter; Provisional; Region: PRK10034; cl15264 290399011339 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 290399011340 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 290399011341 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 290399011342 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 290399011343 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 290399011344 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 290399011345 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 290399011346 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 290399011347 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 290399011348 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399011349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399011350 putative substrate translocation pore; other site 290399011351 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399011352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 290399011353 DNA-binding site [nucleotide binding]; DNA binding site 290399011354 FCD domain; Region: FCD; pfam07729 290399011355 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290399011356 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 290399011357 putative active site [active] 290399011358 catalytic triad [active] 290399011359 putative dimer interface [polypeptide binding]; other site 290399011360 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399011361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399011362 DNA-binding site [nucleotide binding]; DNA binding site 290399011363 FCD domain; Region: FCD; pfam07729 290399011364 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290399011365 Aspartase; Region: Aspartase; cd01357 290399011366 active sites [active] 290399011367 tetramer interface [polypeptide binding]; other site 290399011368 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290399011369 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 290399011370 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399011371 glutaminase A; Region: Gln_ase; TIGR03814 290399011372 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 290399011373 L-asparagine permease; Provisional; Region: PRK15049 290399011374 thiamine pyrophosphate protein; Validated; Region: PRK08199 290399011375 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290399011376 PYR/PP interface [polypeptide binding]; other site 290399011377 dimer interface [polypeptide binding]; other site 290399011378 TPP binding site [chemical binding]; other site 290399011379 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399011380 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 290399011381 TPP-binding site [chemical binding]; other site 290399011382 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 290399011383 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 290399011384 putative hydrophobic ligand binding site [chemical binding]; other site 290399011385 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 290399011386 putative Zn2+ binding site [ion binding]; other site 290399011387 putative DNA binding site [nucleotide binding]; other site 290399011388 dimerization interface [polypeptide binding]; other site 290399011389 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290399011390 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290399011391 active site 290399011392 non-prolyl cis peptide bond; other site 290399011393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 290399011394 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 290399011395 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399011396 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399011397 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399011398 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399011399 S-methylmethionine transporter; Provisional; Region: PRK11387 290399011400 homoserine dehydrogenase; Provisional; Region: PRK06270 290399011401 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290399011402 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 290399011403 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399011404 NAD(P) binding site [chemical binding]; other site 290399011405 catalytic residues [active] 290399011406 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399011407 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290399011408 putative DNA binding site [nucleotide binding]; other site 290399011409 putative Zn2+ binding site [ion binding]; other site 290399011410 AsnC family; Region: AsnC_trans_reg; pfam01037 290399011411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290399011412 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290399011413 active site 290399011414 motif I; other site 290399011415 motif II; other site 290399011416 LabA_like proteins; Region: LabA_like; cd06167 290399011417 putative metal binding site [ion binding]; other site 290399011418 Uncharacterized conserved protein [Function unknown]; Region: COG1432 290399011419 Protein of unknown function (DUF817); Region: DUF817; pfam05675 290399011420 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 290399011421 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290399011422 nudix motif; other site 290399011423 TfoX N-terminal domain; Region: TfoX_N; cl17592 290399011424 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290399011425 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290399011426 active site 290399011427 metal binding site [ion binding]; metal-binding site 290399011428 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 290399011429 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 290399011430 PhoD-like phosphatase; Region: PhoD; pfam09423 290399011431 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290399011432 putative active site [active] 290399011433 putative metal binding site [ion binding]; other site 290399011434 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 290399011435 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 290399011436 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 290399011437 hypothetical protein; Provisional; Region: PRK05463 290399011438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399011439 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399011440 putative substrate translocation pore; other site 290399011441 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 290399011442 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399011443 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 290399011444 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290399011445 RNA binding surface [nucleotide binding]; other site 290399011446 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 290399011447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399011448 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 290399011449 acyl-activating enzyme (AAE) consensus motif; other site 290399011450 putative AMP binding site [chemical binding]; other site 290399011451 putative active site [active] 290399011452 putative CoA binding site [chemical binding]; other site 290399011453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399011454 TAP-like protein; Region: Abhydrolase_4; pfam08386 290399011455 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399011456 active site 290399011457 metal binding site [ion binding]; metal-binding site 290399011458 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399011459 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 290399011460 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 290399011461 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290399011462 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 290399011463 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 290399011464 putative active site [active] 290399011465 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290399011466 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399011467 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399011468 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290399011469 NAD(P) binding site [chemical binding]; other site 290399011470 catalytic residues [active] 290399011471 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 290399011472 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290399011473 metal binding site [ion binding]; metal-binding site 290399011474 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 290399011475 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399011476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399011477 DNA-binding site [nucleotide binding]; DNA binding site 290399011478 FCD domain; Region: FCD; pfam07729 290399011479 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 290399011480 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 290399011481 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399011482 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 290399011483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399011484 active site 290399011485 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 290399011486 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399011487 active site 290399011488 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 290399011489 cytosine deaminase; Provisional; Region: PRK05985 290399011490 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 290399011491 active site 290399011492 Flavodoxin domain; Region: Flavodoxin_5; cl17428 290399011493 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290399011494 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399011495 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 290399011496 DctM-like transporters; Region: DctM; pfam06808 290399011497 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 290399011498 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 290399011499 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 290399011500 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 290399011501 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399011502 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 290399011503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399011504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399011505 DNA binding site [nucleotide binding] 290399011506 domain linker motif; other site 290399011507 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399011508 dimerization interface [polypeptide binding]; other site 290399011509 ligand binding site [chemical binding]; other site 290399011510 Uncharacterized conserved protein [Function unknown]; Region: COG1359 290399011511 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399011512 active site 290399011513 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290399011514 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 290399011515 Phosphotransferase enzyme family; Region: APH; pfam01636 290399011516 active site 290399011517 substrate binding site [chemical binding]; other site 290399011518 ATP binding site [chemical binding]; other site 290399011519 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290399011520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399011521 putative Zn2+ binding site [ion binding]; other site 290399011522 putative DNA binding site [nucleotide binding]; other site 290399011523 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 290399011524 TspO/MBR family; Region: TspO_MBR; pfam03073 290399011525 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 290399011526 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399011527 active site 290399011528 Uncharacterized conserved protein [Function unknown]; Region: COG4748 290399011529 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 290399011530 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 290399011531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399011532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399011533 LysR substrate binding domain; Region: LysR_substrate; pfam03466 290399011534 dimerization interface [polypeptide binding]; other site 290399011535 Cobalt transport protein; Region: CbiQ; cl00463 290399011536 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 290399011537 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290399011538 Walker A/P-loop; other site 290399011539 ATP binding site [chemical binding]; other site 290399011540 Q-loop/lid; other site 290399011541 ABC transporter signature motif; other site 290399011542 Walker B; other site 290399011543 D-loop; other site 290399011544 H-loop/switch region; other site 290399011545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399011546 Walker A/P-loop; other site 290399011547 ATP binding site [chemical binding]; other site 290399011548 Q-loop/lid; other site 290399011549 ABC transporter signature motif; other site 290399011550 Walker B; other site 290399011551 D-loop; other site 290399011552 H-loop/switch region; other site 290399011553 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 290399011554 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 290399011555 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290399011556 Uncharacterized conserved protein [Function unknown]; Region: COG3268 290399011557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399011558 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 290399011559 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 290399011560 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 290399011561 substrate binding pocket [chemical binding]; other site 290399011562 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290399011563 B12 binding site [chemical binding]; other site 290399011564 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 290399011565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290399011566 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 290399011567 substrate binding site [chemical binding]; other site 290399011568 ATP binding site [chemical binding]; other site 290399011569 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 290399011570 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399011571 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 290399011572 Walker A/P-loop; other site 290399011573 ATP binding site [chemical binding]; other site 290399011574 Q-loop/lid; other site 290399011575 ABC transporter signature motif; other site 290399011576 Walker B; other site 290399011577 D-loop; other site 290399011578 H-loop/switch region; other site 290399011579 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 290399011580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399011581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399011582 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 290399011583 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399011584 Walker A/P-loop; other site 290399011585 ATP binding site [chemical binding]; other site 290399011586 Q-loop/lid; other site 290399011587 ABC transporter signature motif; other site 290399011588 Walker B; other site 290399011589 D-loop; other site 290399011590 H-loop/switch region; other site 290399011591 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290399011592 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290399011593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399011594 Walker A/P-loop; other site 290399011595 ATP binding site [chemical binding]; other site 290399011596 Q-loop/lid; other site 290399011597 ABC transporter signature motif; other site 290399011598 Walker B; other site 290399011599 D-loop; other site 290399011600 H-loop/switch region; other site 290399011601 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 290399011602 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 290399011603 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 290399011604 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 290399011605 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 290399011606 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 290399011607 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 290399011608 ligand binding site [chemical binding]; other site 290399011609 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 290399011610 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290399011611 Walker A/P-loop; other site 290399011612 ATP binding site [chemical binding]; other site 290399011613 Q-loop/lid; other site 290399011614 ABC transporter signature motif; other site 290399011615 Walker B; other site 290399011616 D-loop; other site 290399011617 H-loop/switch region; other site 290399011618 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 290399011619 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 290399011620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290399011621 TM-ABC transporter signature motif; other site 290399011622 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 290399011623 Protein of unknown function (DUF917); Region: DUF917; pfam06032 290399011624 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399011625 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 290399011626 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399011627 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 290399011628 active site 290399011629 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290399011630 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399011631 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 290399011632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399011633 active site 290399011634 phosphorylation site [posttranslational modification] 290399011635 intermolecular recognition site; other site 290399011636 dimerization interface [polypeptide binding]; other site 290399011637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399011638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399011639 DNA binding site [nucleotide binding] 290399011640 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 290399011641 active site 290399011642 catalytic residues [active] 290399011643 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290399011644 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290399011645 DXD motif; other site 290399011646 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 290399011647 putative dimer interface [polypeptide binding]; other site 290399011648 [2Fe-2S] cluster binding site [ion binding]; other site 290399011649 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 290399011650 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 290399011651 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 290399011652 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290399011653 catalytic loop [active] 290399011654 iron binding site [ion binding]; other site 290399011655 4Fe-4S binding domain; Region: Fer4; pfam00037 290399011656 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290399011657 molybdopterin cofactor binding site; other site 290399011658 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 290399011659 molybdopterin cofactor binding site; other site 290399011660 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290399011661 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290399011662 putative dimer interface [polypeptide binding]; other site 290399011663 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290399011664 Domain of unknown function DUF21; Region: DUF21; pfam01595 290399011665 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290399011666 Transporter associated domain; Region: CorC_HlyC; smart01091 290399011667 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290399011668 Domain of unknown function DUF21; Region: DUF21; pfam01595 290399011669 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290399011670 Nuclease-related domain; Region: NERD; pfam08378 290399011671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399011672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399011673 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 290399011674 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 290399011675 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 290399011676 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 290399011677 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 290399011678 urea carboxylase; Region: urea_carbox; TIGR02712 290399011679 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290399011680 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290399011681 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290399011682 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 290399011683 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 290399011684 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290399011685 carboxyltransferase (CT) interaction site; other site 290399011686 biotinylation site [posttranslational modification]; other site 290399011687 allophanate hydrolase; Provisional; Region: PRK08186 290399011688 Amidase; Region: Amidase; cl11426 290399011689 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 290399011690 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 290399011691 putative ligand binding site [chemical binding]; other site 290399011692 putative NAD binding site [chemical binding]; other site 290399011693 catalytic site [active] 290399011694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399011695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 290399011696 active site 290399011697 metal binding site [ion binding]; metal-binding site 290399011698 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399011699 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399011700 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 290399011701 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 290399011702 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290399011703 putative hydrophobic ligand binding site [chemical binding]; other site 290399011704 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 290399011705 metal binding site [ion binding]; metal-binding site 290399011706 active site 290399011707 CsbD-like; Region: CsbD; cl17424 290399011708 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399011709 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399011710 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399011711 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 290399011712 conserved cys residue [active] 290399011713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399011714 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399011715 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399011716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399011717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399011718 dimer interface [polypeptide binding]; other site 290399011719 conserved gate region; other site 290399011720 putative PBP binding loops; other site 290399011721 ABC-ATPase subunit interface; other site 290399011722 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 290399011723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399011724 dimer interface [polypeptide binding]; other site 290399011725 conserved gate region; other site 290399011726 putative PBP binding loops; other site 290399011727 ABC-ATPase subunit interface; other site 290399011728 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290399011729 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 290399011730 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399011731 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399011732 DNA binding site [nucleotide binding] 290399011733 domain linker motif; other site 290399011734 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 290399011735 ligand binding site [chemical binding]; other site 290399011736 dimerization interface [polypeptide binding]; other site 290399011737 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 290399011738 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 290399011739 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290399011740 glyoxylate carboligase; Provisional; Region: PRK11269 290399011741 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290399011742 PYR/PP interface [polypeptide binding]; other site 290399011743 dimer interface [polypeptide binding]; other site 290399011744 TPP binding site [chemical binding]; other site 290399011745 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290399011746 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 290399011747 TPP-binding site [chemical binding]; other site 290399011748 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 290399011749 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 290399011750 allantoinase; Region: allantoinase; TIGR03178 290399011751 active site 290399011752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290399011753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290399011754 DNA binding site [nucleotide binding] 290399011755 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290399011756 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290399011757 catalytic triad [active] 290399011758 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 290399011759 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 290399011760 active site 290399011761 catalytic site [active] 290399011762 Zn binding site [ion binding]; other site 290399011763 tetramer interface [polypeptide binding]; other site 290399011764 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290399011765 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 290399011766 Na binding site [ion binding]; other site 290399011767 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 290399011768 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399011769 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290399011770 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290399011771 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290399011772 putative active site [active] 290399011773 putative substrate binding site [chemical binding]; other site 290399011774 putative cosubstrate binding site; other site 290399011775 catalytic site [active] 290399011776 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 290399011777 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 290399011778 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 290399011779 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 290399011780 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 290399011781 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 290399011782 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 290399011783 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290399011784 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 290399011785 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 290399011786 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290399011787 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290399011788 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290399011789 dimer interface [polypeptide binding]; other site 290399011790 active site 290399011791 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290399011792 folate binding site [chemical binding]; other site 290399011793 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399011794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399011795 DNA-binding site [nucleotide binding]; DNA binding site 290399011796 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 290399011797 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 290399011798 active site 290399011799 dimer interface [polypeptide binding]; other site 290399011800 magnesium binding site [ion binding]; other site 290399011801 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 290399011802 tetramer interface [polypeptide binding]; other site 290399011803 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 290399011804 active site 290399011805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 290399011806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399011807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399011808 DNA binding residues [nucleotide binding] 290399011809 dimerization interface [polypeptide binding]; other site 290399011810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399011811 Coenzyme A binding pocket [chemical binding]; other site 290399011812 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290399011813 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399011814 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399011815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399011816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399011817 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290399011818 putative dimerization interface [polypeptide binding]; other site 290399011819 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 290399011820 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 290399011821 [2Fe-2S] cluster binding site [ion binding]; other site 290399011822 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 290399011823 putative alpha subunit interface [polypeptide binding]; other site 290399011824 putative active site [active] 290399011825 putative substrate binding site [chemical binding]; other site 290399011826 Fe binding site [ion binding]; other site 290399011827 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 290399011828 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 290399011829 FAD binding pocket [chemical binding]; other site 290399011830 FAD binding motif [chemical binding]; other site 290399011831 phosphate binding motif [ion binding]; other site 290399011832 beta-alpha-beta structure motif; other site 290399011833 NAD binding pocket [chemical binding]; other site 290399011834 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290399011835 catalytic loop [active] 290399011836 iron binding site [ion binding]; other site 290399011837 BCCT family transporter; Region: BCCT; pfam02028 290399011838 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290399011839 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290399011840 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290399011841 putative active site [active] 290399011842 putative substrate binding site [chemical binding]; other site 290399011843 putative cosubstrate binding site; other site 290399011844 catalytic site [active] 290399011845 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 290399011846 hydroxyglutarate oxidase; Provisional; Region: PRK11728 290399011847 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 290399011848 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290399011849 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 290399011850 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290399011851 active site 290399011852 catalytic site [active] 290399011853 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 290399011854 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 290399011855 putative molybdopterin cofactor binding site [chemical binding]; other site 290399011856 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 290399011857 putative molybdopterin cofactor binding site; other site 290399011858 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290399011859 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 290399011860 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 290399011861 NAD binding site [chemical binding]; other site 290399011862 catalytic Zn binding site [ion binding]; other site 290399011863 substrate binding site [chemical binding]; other site 290399011864 structural Zn binding site [ion binding]; other site 290399011865 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 290399011866 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 290399011867 tetramerization interface [polypeptide binding]; other site 290399011868 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399011869 NAD(P) binding site [chemical binding]; other site 290399011870 catalytic residues [active] 290399011871 choline dehydrogenase; Validated; Region: PRK02106 290399011872 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290399011873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399011874 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399011875 putative substrate translocation pore; other site 290399011876 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290399011877 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290399011878 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 290399011879 active site 290399011880 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399011881 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399011882 putative Zn2+ binding site [ion binding]; other site 290399011883 putative DNA binding site [nucleotide binding]; other site 290399011884 dimerization interface [polypeptide binding]; other site 290399011885 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 290399011886 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399011887 OpgC protein; Region: OpgC_C; pfam10129 290399011888 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290399011889 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290399011890 GAF domain; Region: GAF; pfam01590 290399011891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399011892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399011893 dimer interface [polypeptide binding]; other site 290399011894 phosphorylation site [posttranslational modification] 290399011895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399011896 ATP binding site [chemical binding]; other site 290399011897 Mg2+ binding site [ion binding]; other site 290399011898 G-X-G motif; other site 290399011899 putative OHCU decarboxylase; Provisional; Region: PRK13798 290399011900 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 290399011901 active site 290399011902 homotetramer interface [polypeptide binding]; other site 290399011903 amidophosphoribosyltransferase; Provisional; Region: PRK07847 290399011904 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 290399011905 active site 290399011906 tetramer interface [polypeptide binding]; other site 290399011907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290399011908 active site 290399011909 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 290399011910 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 290399011911 dimerization interface [polypeptide binding]; other site 290399011912 putative ATP binding site [chemical binding]; other site 290399011913 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399011914 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399011915 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290399011916 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 290399011917 Septum formation; Region: Septum_form; pfam13845 290399011918 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 290399011919 Clp amino terminal domain; Region: Clp_N; pfam02861 290399011920 Clp amino terminal domain; Region: Clp_N; pfam02861 290399011921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399011922 Walker A motif; other site 290399011923 ATP binding site [chemical binding]; other site 290399011924 Walker B motif; other site 290399011925 arginine finger; other site 290399011926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399011927 Walker A motif; other site 290399011928 ATP binding site [chemical binding]; other site 290399011929 Walker B motif; other site 290399011930 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290399011931 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 290399011932 cleavage site 290399011933 active site 290399011934 substrate binding sites [chemical binding]; other site 290399011935 Uncharacterized conserved protein [Function unknown]; Region: COG2128 290399011936 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 290399011937 choline dehydrogenase; Validated; Region: PRK02106 290399011938 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 290399011939 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290399011940 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399011941 NAD(P) binding site [chemical binding]; other site 290399011942 catalytic residues [active] 290399011943 BCCT family transporter; Region: BCCT; cl00569 290399011944 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 290399011945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399011946 Walker A/P-loop; other site 290399011947 ATP binding site [chemical binding]; other site 290399011948 Q-loop/lid; other site 290399011949 ABC transporter signature motif; other site 290399011950 Walker B; other site 290399011951 D-loop; other site 290399011952 H-loop/switch region; other site 290399011953 TOBE domain; Region: TOBE; pfam03459 290399011954 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290399011955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399011956 dimer interface [polypeptide binding]; other site 290399011957 conserved gate region; other site 290399011958 putative PBP binding loops; other site 290399011959 ABC-ATPase subunit interface; other site 290399011960 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290399011961 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290399011962 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 290399011963 DNA binding residues [nucleotide binding] 290399011964 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290399011965 TOBE domain; Region: TOBE; cl01440 290399011966 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290399011967 FAD binding domain; Region: FAD_binding_4; pfam01565 290399011968 Berberine and berberine like; Region: BBE; pfam08031 290399011969 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 290399011970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 290399011971 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 290399011972 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 290399011973 hypothetical protein; Provisional; Region: PRK11770 290399011974 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290399011975 Domain of unknown function (DUF307); Region: DUF307; pfam03733 290399011976 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 290399011977 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 290399011978 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290399011979 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 290399011980 oligomer interface [polypeptide binding]; other site 290399011981 metal binding site [ion binding]; metal-binding site 290399011982 metal binding site [ion binding]; metal-binding site 290399011983 putative Cl binding site [ion binding]; other site 290399011984 basic sphincter; other site 290399011985 hydrophobic gate; other site 290399011986 periplasmic entrance; other site 290399011987 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290399011988 Beta-lactamase; Region: Beta-lactamase; pfam00144 290399011989 Uncharacterized conserved protein [Function unknown]; Region: COG2353 290399011990 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290399011991 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 290399011992 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 290399011993 active site 290399011994 HutD; Region: HutD; pfam05962 290399011995 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 290399011996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399011997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399011998 DNA binding site [nucleotide binding] 290399011999 domain linker motif; other site 290399012000 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 290399012001 ligand binding site [chemical binding]; other site 290399012002 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 290399012003 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 290399012004 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399012005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399012006 DNA binding site [nucleotide binding] 290399012007 domain linker motif; other site 290399012008 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 290399012009 putative dimerization interface [polypeptide binding]; other site 290399012010 putative ligand binding site [chemical binding]; other site 290399012011 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 290399012012 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 290399012013 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 290399012014 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 290399012015 Ca binding site [ion binding]; other site 290399012016 active site 290399012017 catalytic site [active] 290399012018 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 290399012019 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 290399012020 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 290399012021 active site 290399012022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290399012023 dimerization interface [polypeptide binding]; other site 290399012024 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290399012025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290399012026 metal binding site [ion binding]; metal-binding site 290399012027 active site 290399012028 I-site; other site 290399012029 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399012030 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399012031 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399012032 active site 290399012033 catalytic tetrad [active] 290399012034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290399012035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290399012036 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290399012037 ATP binding site [chemical binding]; other site 290399012038 putative Mg++ binding site [ion binding]; other site 290399012039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399012040 nucleotide binding region [chemical binding]; other site 290399012041 ATP-binding site [chemical binding]; other site 290399012042 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 290399012043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399012045 putative substrate translocation pore; other site 290399012046 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 290399012047 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 290399012048 AsnC family; Region: AsnC_trans_reg; pfam01037 290399012049 MarR family; Region: MarR_2; cl17246 290399012050 AsnC family; Region: AsnC_trans_reg; pfam01037 290399012051 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290399012052 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 290399012053 metal binding site [ion binding]; metal-binding site 290399012054 dimer interface [polypeptide binding]; other site 290399012055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012056 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399012057 putative substrate translocation pore; other site 290399012058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399012059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012060 NMT1-like family; Region: NMT1_2; pfam13379 290399012061 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 290399012062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012063 cyanate transporter; Region: CynX; TIGR00896 290399012064 putative substrate translocation pore; other site 290399012065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399012066 S-adenosylmethionine binding site [chemical binding]; other site 290399012067 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 290399012068 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 290399012069 hydrophobic ligand binding site; other site 290399012070 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290399012071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399012072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012073 homodimer interface [polypeptide binding]; other site 290399012074 catalytic residue [active] 290399012075 Putative zinc-finger; Region: zf-HC2; pfam13490 290399012076 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 290399012077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290399012078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399012079 DNA binding residues [nucleotide binding] 290399012080 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290399012081 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290399012082 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290399012083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290399012084 DNA binding residues [nucleotide binding] 290399012085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399012086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290399012087 dimer interface [polypeptide binding]; other site 290399012088 phosphorylation site [posttranslational modification] 290399012089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399012090 ATP binding site [chemical binding]; other site 290399012091 Mg2+ binding site [ion binding]; other site 290399012092 G-X-G motif; other site 290399012093 aminotransferase AlaT; Validated; Region: PRK09265 290399012094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399012095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012096 homodimer interface [polypeptide binding]; other site 290399012097 catalytic residue [active] 290399012098 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 290399012099 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 290399012100 substrate binding [chemical binding]; other site 290399012101 active site 290399012102 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 290399012103 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 290399012104 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290399012105 ATP binding site [chemical binding]; other site 290399012106 putative Mg++ binding site [ion binding]; other site 290399012107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290399012108 nucleotide binding region [chemical binding]; other site 290399012109 ATP-binding site [chemical binding]; other site 290399012110 ANTAR domain; Region: ANTAR; pfam03861 290399012111 GAF domain; Region: GAF_2; pfam13185 290399012112 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 290399012113 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290399012114 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 290399012115 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 290399012116 DNA binding residues [nucleotide binding] 290399012117 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290399012118 putative dimer interface [polypeptide binding]; other site 290399012119 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 290399012120 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290399012121 HSP70 interaction site [polypeptide binding]; other site 290399012122 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290399012123 dimer interface [polypeptide binding]; other site 290399012124 GrpE; Region: GrpE; pfam01025 290399012125 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 290399012126 dimer interface [polypeptide binding]; other site 290399012127 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 290399012128 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290399012129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 290399012130 nucleotide binding site [chemical binding]; other site 290399012131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399012132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399012133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399012134 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399012135 NAD(P) binding site [chemical binding]; other site 290399012136 active site 290399012137 MMPL family; Region: MMPL; pfam03176 290399012138 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 290399012139 MarR family; Region: MarR_2; pfam12802 290399012140 RibD C-terminal domain; Region: RibD_C; cl17279 290399012141 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290399012142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290399012143 S-adenosylmethionine binding site [chemical binding]; other site 290399012144 RibD C-terminal domain; Region: RibD_C; cl17279 290399012145 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290399012146 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 290399012147 Clp amino terminal domain; Region: Clp_N; pfam02861 290399012148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399012149 Walker A motif; other site 290399012150 ATP binding site [chemical binding]; other site 290399012151 Walker B motif; other site 290399012152 arginine finger; other site 290399012153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399012154 Walker A motif; other site 290399012155 ATP binding site [chemical binding]; other site 290399012156 Walker B motif; other site 290399012157 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290399012158 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 290399012159 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290399012160 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 290399012161 acyl-activating enzyme (AAE) consensus motif; other site 290399012162 putative AMP binding site [chemical binding]; other site 290399012163 putative active site [active] 290399012164 putative CoA binding site [chemical binding]; other site 290399012165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012166 putative substrate translocation pore; other site 290399012167 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 290399012168 putative active site [active] 290399012169 putative catalytic site [active] 290399012170 acyl-coenzyme A oxidase; Region: PLN02526 290399012171 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399012172 active site 290399012173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 290399012174 active site 290399012175 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290399012176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399012177 NAD(P) binding site [chemical binding]; other site 290399012178 active site 290399012179 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290399012180 MarR family; Region: MarR; pfam01047 290399012181 MarR family; Region: MarR_2; cl17246 290399012182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399012183 dimerization interface [polypeptide binding]; other site 290399012184 putative DNA binding site [nucleotide binding]; other site 290399012185 putative Zn2+ binding site [ion binding]; other site 290399012186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399012189 putative substrate translocation pore; other site 290399012190 Domain of unknown function DUF302; Region: DUF302; pfam03625 290399012191 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290399012192 putative homodimer interface [polypeptide binding]; other site 290399012193 putative homotetramer interface [polypeptide binding]; other site 290399012194 putative allosteric switch controlling residues; other site 290399012195 putative metal binding site [ion binding]; other site 290399012196 putative homodimer-homodimer interface [polypeptide binding]; other site 290399012197 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290399012198 active site residue [active] 290399012199 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290399012200 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290399012201 active site residue [active] 290399012202 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290399012203 active site residue [active] 290399012204 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290399012205 catalytic residues [active] 290399012206 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290399012207 active site residue [active] 290399012208 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 290399012209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290399012210 active site residue [active] 290399012211 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 290399012212 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290399012213 Catalytic site [active] 290399012214 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290399012215 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290399012216 active site 290399012217 DNA binding site [nucleotide binding] 290399012218 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290399012219 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 290399012220 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 290399012221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290399012222 FeS/SAM binding site; other site 290399012223 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 290399012224 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290399012225 Low molecular weight phosphatase family; Region: LMWPc; cl00105 290399012226 active site 290399012227 hypothetical protein; Provisional; Region: PRK06547 290399012228 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 290399012229 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290399012230 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290399012231 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 290399012232 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 290399012233 putative active site [active] 290399012234 catalytic site [active] 290399012235 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 290399012236 putative active site [active] 290399012237 catalytic site [active] 290399012238 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290399012239 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 290399012240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012241 catalytic residue [active] 290399012242 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290399012243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290399012244 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290399012245 Protein of unknown function (DUF664); Region: DUF664; pfam04978 290399012246 DinB superfamily; Region: DinB_2; pfam12867 290399012247 Transposase; Region: DEDD_Tnp_IS110; pfam01548 290399012248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 290399012249 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 290399012250 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 290399012251 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290399012252 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290399012253 dimer interface [polypeptide binding]; other site 290399012254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012255 catalytic residue [active] 290399012256 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 290399012257 active sites [active] 290399012258 tetramer interface [polypeptide binding]; other site 290399012259 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290399012260 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290399012261 active site 290399012262 non-prolyl cis peptide bond; other site 290399012263 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 290399012264 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290399012265 active site residue [active] 290399012266 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 290399012267 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290399012268 homodimer interface [polypeptide binding]; other site 290399012269 substrate-cofactor binding pocket; other site 290399012270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012271 catalytic residue [active] 290399012272 carboxylate-amine ligase; Provisional; Region: PRK13517 290399012273 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 290399012274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290399012275 non-specific DNA binding site [nucleotide binding]; other site 290399012276 salt bridge; other site 290399012277 sequence-specific DNA binding site [nucleotide binding]; other site 290399012278 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290399012279 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 290399012280 putative active site [active] 290399012281 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 290399012282 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290399012283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290399012284 Walker A/P-loop; other site 290399012285 ATP binding site [chemical binding]; other site 290399012286 Q-loop/lid; other site 290399012287 ABC transporter signature motif; other site 290399012288 Walker B; other site 290399012289 D-loop; other site 290399012290 H-loop/switch region; other site 290399012291 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290399012292 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 290399012293 Walker A/P-loop; other site 290399012294 ATP binding site [chemical binding]; other site 290399012295 Q-loop/lid; other site 290399012296 ABC transporter signature motif; other site 290399012297 Walker B; other site 290399012298 D-loop; other site 290399012299 H-loop/switch region; other site 290399012300 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 290399012301 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 290399012302 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 290399012303 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 290399012304 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 290399012305 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 290399012306 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290399012307 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 290399012308 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 290399012309 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290399012310 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 290399012311 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 290399012312 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 290399012313 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 290399012314 TrkA-C domain; Region: TrkA_C; pfam02080 290399012315 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 290399012316 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290399012317 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290399012318 trimer interface [polypeptide binding]; other site 290399012319 active site 290399012320 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 290399012321 Family description; Region: VCBS; pfam13517 290399012322 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 290399012323 putative hydrophobic ligand binding site [chemical binding]; other site 290399012324 N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181 290399012325 putative active site [active] 290399012326 putative ligand binding site [chemical binding]; other site 290399012327 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; pfam01262 290399012328 putative NAD(P) binding site [chemical binding]; other site 290399012329 H+ Antiporter protein; Region: 2A0121; TIGR00900 290399012330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399012332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399012333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 290399012334 dimerization interface [polypeptide binding]; other site 290399012335 Proline dehydrogenase; Region: Pro_dh; cl03282 290399012336 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 290399012337 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290399012338 NAD(P) binding site [chemical binding]; other site 290399012339 catalytic residues [active] 290399012340 amino acid transporter; Region: 2A0306; TIGR00909 290399012341 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 290399012342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 290399012343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 290399012344 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 290399012345 putative dimerization interface [polypeptide binding]; other site 290399012346 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290399012347 tetramerization interface [polypeptide binding]; other site 290399012348 active site 290399012349 Predicted permeases [General function prediction only]; Region: COG0679 290399012350 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 290399012351 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 290399012352 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 290399012353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399012354 Response regulator receiver domain; Region: Response_reg; pfam00072 290399012355 active site 290399012356 phosphorylation site [posttranslational modification] 290399012357 intermolecular recognition site; other site 290399012358 dimerization interface [polypeptide binding]; other site 290399012359 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 290399012360 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 290399012361 Domain of unknown function (DUF377); Region: DUF377; pfam04041 290399012362 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 290399012363 active site 290399012364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 290399012365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399012366 dimer interface [polypeptide binding]; other site 290399012367 conserved gate region; other site 290399012368 putative PBP binding loops; other site 290399012369 ABC-ATPase subunit interface; other site 290399012370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399012371 dimer interface [polypeptide binding]; other site 290399012372 conserved gate region; other site 290399012373 putative PBP binding loops; other site 290399012374 ABC-ATPase subunit interface; other site 290399012375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 290399012376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290399012377 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399012378 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399012379 DNA binding site [nucleotide binding] 290399012380 domain linker motif; other site 290399012381 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399012382 ligand binding site [chemical binding]; other site 290399012383 dimerization interface [polypeptide binding]; other site 290399012384 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 290399012385 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290399012386 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290399012387 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 290399012388 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 290399012389 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 290399012390 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 290399012391 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 290399012392 potential catalytic triad [active] 290399012393 conserved cys residue [active] 290399012394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399012395 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290399012396 substrate binding pocket [chemical binding]; other site 290399012397 membrane-bound complex binding site; other site 290399012398 hinge residues; other site 290399012399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399012400 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 290399012401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290399012402 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290399012403 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 290399012404 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 290399012405 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 290399012406 active site 290399012407 non-prolyl cis peptide bond; other site 290399012408 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290399012409 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 290399012410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 290399012411 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 290399012412 substrate binding pocket [chemical binding]; other site 290399012413 membrane-bound complex binding site; other site 290399012414 hinge residues; other site 290399012415 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 290399012416 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 290399012417 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 290399012418 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 290399012419 Walker A/P-loop; other site 290399012420 ATP binding site [chemical binding]; other site 290399012421 Q-loop/lid; other site 290399012422 ABC transporter signature motif; other site 290399012423 Walker B; other site 290399012424 D-loop; other site 290399012425 H-loop/switch region; other site 290399012426 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 290399012427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399012428 dimer interface [polypeptide binding]; other site 290399012429 conserved gate region; other site 290399012430 putative PBP binding loops; other site 290399012431 ABC-ATPase subunit interface; other site 290399012432 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 290399012433 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 290399012434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399012435 Coenzyme A binding pocket [chemical binding]; other site 290399012436 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 290399012437 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 290399012438 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290399012439 NHL repeat; Region: NHL; pfam01436 290399012440 Copper resistance protein D; Region: CopD; pfam05425 290399012441 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 290399012442 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290399012443 IHF dimer interface [polypeptide binding]; other site 290399012444 IHF - DNA interface [nucleotide binding]; other site 290399012445 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 290399012446 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 290399012447 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 290399012448 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 290399012449 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 290399012450 Transcriptional regulators [Transcription]; Region: PurR; COG1609 290399012451 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 290399012452 DNA binding site [nucleotide binding] 290399012453 domain linker motif; other site 290399012454 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 290399012455 ligand binding site [chemical binding]; other site 290399012456 dimerization interface [polypeptide binding]; other site 290399012457 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 290399012458 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 290399012459 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 290399012460 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 290399012461 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 290399012462 FAD binding pocket [chemical binding]; other site 290399012463 FAD binding motif [chemical binding]; other site 290399012464 phosphate binding motif [ion binding]; other site 290399012465 beta-alpha-beta structure motif; other site 290399012466 NAD binding pocket [chemical binding]; other site 290399012467 FMN-binding domain; Region: FMN_bind; cl01081 290399012468 ApbE family; Region: ApbE; pfam02424 290399012469 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290399012470 active site 290399012471 catalytic triad [active] 290399012472 oxyanion hole [active] 290399012473 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 290399012474 glutaminase; Provisional; Region: PRK00971 290399012475 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 290399012476 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290399012477 ligand binding site [chemical binding]; other site 290399012478 flexible hinge region; other site 290399012479 MarR family; Region: MarR_2; cl17246 290399012480 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 290399012481 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 290399012482 YCII-related domain; Region: YCII; cl00999 290399012483 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 290399012484 active site 290399012485 catalytic triad [active] 290399012486 oxyanion hole [active] 290399012487 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 290399012488 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 290399012489 FAD binding pocket [chemical binding]; other site 290399012490 FAD binding motif [chemical binding]; other site 290399012491 phosphate binding motif [ion binding]; other site 290399012492 NAD binding pocket [chemical binding]; other site 290399012493 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290399012494 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290399012495 Walker A/P-loop; other site 290399012496 ATP binding site [chemical binding]; other site 290399012497 Q-loop/lid; other site 290399012498 ABC transporter signature motif; other site 290399012499 Walker B; other site 290399012500 D-loop; other site 290399012501 H-loop/switch region; other site 290399012502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 290399012503 FecCD transport family; Region: FecCD; pfam01032 290399012504 dimer interface [polypeptide binding]; other site 290399012505 putative PBP binding regions; other site 290399012506 ABC-ATPase subunit interface; other site 290399012507 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290399012508 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290399012509 ABC-ATPase subunit interface; other site 290399012510 dimer interface [polypeptide binding]; other site 290399012511 putative PBP binding regions; other site 290399012512 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 290399012513 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290399012514 intersubunit interface [polypeptide binding]; other site 290399012515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012516 putative substrate translocation pore; other site 290399012517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012518 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290399012519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399012520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399012521 hypothetical protein; Provisional; Region: PHA02755 290399012522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 290399012523 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 290399012524 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 290399012525 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 290399012526 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 290399012527 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 290399012528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 290399012529 active site 290399012530 hypothetical protein; Provisional; Region: PRK04233 290399012531 SEC-C motif; Region: SEC-C; pfam02810 290399012532 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399012533 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399012534 active site 290399012535 catalytic tetrad [active] 290399012536 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290399012537 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290399012538 active site 290399012539 catalytic tetrad [active] 290399012540 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 290399012541 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 290399012542 NADP binding site [chemical binding]; other site 290399012543 sulfite oxidase; Provisional; Region: PLN00177 290399012544 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 290399012545 Moco binding site; other site 290399012546 metal coordination site [ion binding]; other site 290399012547 dimerization interface [polypeptide binding]; other site 290399012548 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 290399012549 dihydroxyacetone kinase; Provisional; Region: PRK14479 290399012550 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 290399012551 DAK2 domain; Region: Dak2; pfam02734 290399012552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399012553 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290399012554 NAD(P) binding site [chemical binding]; other site 290399012555 active site 290399012556 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399012557 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399012558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012559 putative substrate translocation pore; other site 290399012560 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290399012561 TPP-binding site [chemical binding]; other site 290399012562 dimer interface [polypeptide binding]; other site 290399012563 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290399012564 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290399012565 PYR/PP interface [polypeptide binding]; other site 290399012566 dimer interface [polypeptide binding]; other site 290399012567 TPP binding site [chemical binding]; other site 290399012568 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399012569 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399012570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399012571 DNA-binding site [nucleotide binding]; DNA binding site 290399012572 FCD domain; Region: FCD; pfam07729 290399012573 short chain dehydrogenase; Provisional; Region: PRK07890 290399012574 classical (c) SDRs; Region: SDR_c; cd05233 290399012575 NAD(P) binding site [chemical binding]; other site 290399012576 active site 290399012577 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 290399012578 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 290399012579 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 290399012580 catalytic Zn binding site [ion binding]; other site 290399012581 structural Zn binding site [ion binding]; other site 290399012582 NAD(P) binding site [chemical binding]; other site 290399012583 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399012584 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 290399012585 active site 290399012586 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 290399012587 putative hydrophobic ligand binding site [chemical binding]; other site 290399012588 Domain of unknown function (DUF222); Region: DUF222; pfam02720 290399012589 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290399012590 active site 290399012591 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290399012592 active site 290399012593 catalytic site [active] 290399012594 substrate binding site [chemical binding]; other site 290399012595 BRCA1 C Terminus (BRCT) domain; Region: BRCT; pfam00533 290399012596 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 290399012597 putative uracil binding site [chemical binding]; other site 290399012598 putative active site [active] 290399012599 HipA N-terminal domain; Region: Couple_hipA; pfam13657 290399012600 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 290399012601 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290399012602 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290399012603 transcriptional regulator, y4mF family; Region: couple_hipB; TIGR03070 290399012604 sequence-specific DNA binding site [nucleotide binding]; other site 290399012605 salt bridge; other site 290399012606 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399012607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399012608 DNA-binding site [nucleotide binding]; DNA binding site 290399012609 FCD domain; Region: FCD; pfam07729 290399012610 L-asparaginase II; Region: Asparaginase_II; pfam06089 290399012611 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 290399012612 Aspartase; Region: Aspartase; cd01357 290399012613 active sites [active] 290399012614 tetramer interface [polypeptide binding]; other site 290399012615 L-asparagine permease; Provisional; Region: PRK15049 290399012616 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 290399012617 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 290399012618 NAD binding site [chemical binding]; other site 290399012619 dimer interface [polypeptide binding]; other site 290399012620 substrate binding site [chemical binding]; other site 290399012621 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290399012622 Domain of unknown function (DUF305); Region: DUF305; pfam03713 290399012623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399012624 Coenzyme A binding pocket [chemical binding]; other site 290399012625 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290399012626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290399012627 Walker A motif; other site 290399012628 ATP binding site [chemical binding]; other site 290399012629 Walker B motif; other site 290399012630 arginine finger; other site 290399012631 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 290399012632 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 290399012633 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 290399012634 substrate binding pocket [chemical binding]; other site 290399012635 catalytic triad [active] 290399012636 HD domain; Region: HD_4; pfam13328 290399012637 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 290399012638 active site 290399012639 HIGH motif; other site 290399012640 nucleotide binding site [chemical binding]; other site 290399012641 KMSKS motif; other site 290399012642 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399012643 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 290399012644 AsnC family; Region: AsnC_trans_reg; pfam01037 290399012645 Proteins of 100 residues with WXG; Region: WXG100; cl02005 290399012646 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290399012647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399012648 putative DNA binding site [nucleotide binding]; other site 290399012649 putative Zn2+ binding site [ion binding]; other site 290399012650 AsnC family; Region: AsnC_trans_reg; pfam01037 290399012651 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290399012652 SnoaL-like domain; Region: SnoaL_2; pfam12680 290399012653 Protein of unknown function (DUF456); Region: DUF456; pfam04306 290399012654 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 290399012655 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290399012656 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 290399012657 NAD(P) binding pocket [chemical binding]; other site 290399012658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399012659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399012660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399012661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012662 putative substrate translocation pore; other site 290399012663 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 290399012664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290399012666 putative substrate translocation pore; other site 290399012667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012669 putative substrate translocation pore; other site 290399012670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012672 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 290399012673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 290399012674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290399012675 putative Zn2+ binding site [ion binding]; other site 290399012676 putative DNA binding site [nucleotide binding]; other site 290399012677 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 290399012678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399012679 Coenzyme A binding pocket [chemical binding]; other site 290399012680 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 290399012681 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 290399012682 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 290399012683 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 290399012684 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 290399012685 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 290399012686 active site 290399012687 P-loop; other site 290399012688 phosphorylation site [posttranslational modification] 290399012689 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290399012690 active site 290399012691 phosphorylation site [posttranslational modification] 290399012692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399012693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399012694 WHG domain; Region: WHG; pfam13305 290399012695 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290399012696 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 290399012697 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290399012698 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290399012699 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290399012700 dimerization domain swap beta strand [polypeptide binding]; other site 290399012701 regulatory protein interface [polypeptide binding]; other site 290399012702 active site 290399012703 regulatory phosphorylation site [posttranslational modification]; other site 290399012704 Helix-turn-helix domain; Region: HTH_17; pfam12728 290399012705 FAD binding domain; Region: FAD_binding_4; pfam01565 290399012706 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 290399012707 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 290399012708 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 290399012709 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290399012710 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 290399012711 hexamer interface [polypeptide binding]; other site 290399012712 ligand binding site [chemical binding]; other site 290399012713 putative active site [active] 290399012714 NAD(P) binding site [chemical binding]; other site 290399012715 putative oxidoreductase; Provisional; Region: PRK11579 290399012716 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399012717 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399012718 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 290399012719 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 290399012720 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290399012721 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399012722 Walker A/P-loop; other site 290399012723 ATP binding site [chemical binding]; other site 290399012724 Q-loop/lid; other site 290399012725 ABC transporter signature motif; other site 290399012726 Walker B; other site 290399012727 D-loop; other site 290399012728 H-loop/switch region; other site 290399012729 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 290399012730 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 290399012731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290399012732 Walker A/P-loop; other site 290399012733 ATP binding site [chemical binding]; other site 290399012734 Q-loop/lid; other site 290399012735 ABC transporter signature motif; other site 290399012736 Walker B; other site 290399012737 D-loop; other site 290399012738 H-loop/switch region; other site 290399012739 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 290399012740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290399012741 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290399012742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399012743 dimer interface [polypeptide binding]; other site 290399012744 conserved gate region; other site 290399012745 putative PBP binding loops; other site 290399012746 ABC-ATPase subunit interface; other site 290399012747 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290399012748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399012749 dimer interface [polypeptide binding]; other site 290399012750 conserved gate region; other site 290399012751 putative PBP binding loops; other site 290399012752 ABC-ATPase subunit interface; other site 290399012753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290399012754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290399012755 Predicted flavoprotein [General function prediction only]; Region: COG0431 290399012756 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290399012757 Sporulation and spore germination; Region: Germane; pfam10646 290399012758 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 290399012759 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 290399012760 tetramer interface [polypeptide binding]; other site 290399012761 active site 290399012762 Mg2+/Mn2+ binding site [ion binding]; other site 290399012763 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290399012764 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399012765 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012766 homodimer interface [polypeptide binding]; other site 290399012767 catalytic residue [active] 290399012768 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399012769 Ligand Binding Site [chemical binding]; other site 290399012770 4-coumarate--CoA ligase; Region: PLN02246 290399012771 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 290399012772 acyl-activating enzyme (AAE) consensus motif; other site 290399012773 active site 290399012774 putative CoA binding site [chemical binding]; other site 290399012775 AMP binding site [chemical binding]; other site 290399012776 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290399012777 E3 interaction surface; other site 290399012778 lipoyl attachment site [posttranslational modification]; other site 290399012779 e3 binding domain; Region: E3_binding; pfam02817 290399012780 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 290399012781 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290399012782 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 290399012783 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 290399012784 alpha subunit interface [polypeptide binding]; other site 290399012785 TPP binding site [chemical binding]; other site 290399012786 heterodimer interface [polypeptide binding]; other site 290399012787 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290399012788 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 290399012789 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 290399012790 tetramer interface [polypeptide binding]; other site 290399012791 TPP-binding site [chemical binding]; other site 290399012792 heterodimer interface [polypeptide binding]; other site 290399012793 phosphorylation loop region [posttranslational modification] 290399012794 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 290399012795 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290399012796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012797 homodimer interface [polypeptide binding]; other site 290399012798 catalytic residue [active] 290399012799 Membrane protein of unknown function; Region: DUF360; pfam04020 290399012800 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 290399012801 nucleophilic elbow; other site 290399012802 catalytic triad; other site 290399012803 adenylosuccinate lyase; Provisional; Region: PRK09285 290399012804 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 290399012805 tetramer interface [polypeptide binding]; other site 290399012806 active site 290399012807 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399012808 catalytic core [active] 290399012809 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 290399012810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 290399012811 active site 290399012812 ATP binding site [chemical binding]; other site 290399012813 substrate binding site [chemical binding]; other site 290399012814 activation loop (A-loop); other site 290399012815 MarR family; Region: MarR; pfam01047 290399012816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290399012817 Coenzyme A binding pocket [chemical binding]; other site 290399012818 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290399012819 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 290399012820 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 290399012821 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 290399012822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399012823 Walker A/P-loop; other site 290399012824 ATP binding site [chemical binding]; other site 290399012825 Q-loop/lid; other site 290399012826 ABC transporter signature motif; other site 290399012827 Walker B; other site 290399012828 D-loop; other site 290399012829 H-loop/switch region; other site 290399012830 TOBE domain; Region: TOBE_2; pfam08402 290399012831 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 290399012832 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290399012833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399012834 dimer interface [polypeptide binding]; other site 290399012835 conserved gate region; other site 290399012836 putative PBP binding loops; other site 290399012837 ABC-ATPase subunit interface; other site 290399012838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290399012839 dimer interface [polypeptide binding]; other site 290399012840 conserved gate region; other site 290399012841 putative PBP binding loops; other site 290399012842 ABC-ATPase subunit interface; other site 290399012843 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399012844 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399012845 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 290399012846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399012847 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 290399012848 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399012849 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 290399012850 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399012851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012852 benzoate transport; Region: 2A0115; TIGR00895 290399012853 putative substrate translocation pore; other site 290399012854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012855 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 290399012856 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 290399012857 [4Fe-4S] binding site [ion binding]; other site 290399012858 molybdopterin cofactor binding site; other site 290399012859 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 290399012860 molybdopterin cofactor binding site; other site 290399012861 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 290399012862 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 290399012863 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 290399012864 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290399012865 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290399012866 inhibitor-cofactor binding pocket; inhibition site 290399012867 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012868 catalytic residue [active] 290399012869 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 290399012870 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290399012871 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290399012872 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290399012873 Probable Catalytic site; other site 290399012874 metal-binding site 290399012875 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290399012876 active site 290399012877 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290399012878 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 290399012879 putative trimer interface [polypeptide binding]; other site 290399012880 putative active site [active] 290399012881 putative substrate binding site [chemical binding]; other site 290399012882 putative CoA binding site [chemical binding]; other site 290399012883 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399012884 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290399012885 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290399012886 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290399012887 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290399012888 inhibitor-cofactor binding pocket; inhibition site 290399012889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012890 catalytic residue [active] 290399012891 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 290399012892 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 290399012893 putative trimer interface [polypeptide binding]; other site 290399012894 putative CoA binding site [chemical binding]; other site 290399012895 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290399012896 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290399012897 inhibitor-cofactor binding pocket; inhibition site 290399012898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290399012899 catalytic residue [active] 290399012900 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290399012901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290399012902 NAD(P) binding site [chemical binding]; other site 290399012903 active site 290399012904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290399012905 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290399012906 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290399012907 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290399012908 Bacterial sugar transferase; Region: Bac_transf; pfam02397 290399012909 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 290399012910 D-galactonate transporter; Region: 2A0114; TIGR00893 290399012911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012912 putative substrate translocation pore; other site 290399012913 Transcriptional regulators [Transcription]; Region: GntR; COG1802 290399012914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399012915 DNA-binding site [nucleotide binding]; DNA binding site 290399012916 FCD domain; Region: FCD; pfam07729 290399012917 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290399012918 phenylhydantoinase; Validated; Region: PRK08323 290399012919 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290399012920 active site 290399012921 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 290399012922 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290399012923 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290399012924 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 290399012925 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 290399012926 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290399012927 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399012928 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 290399012929 Coenzyme A transferase; Region: CoA_trans; cl17247 290399012930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 290399012931 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 290399012932 dimer interface [polypeptide binding]; other site 290399012933 active site 290399012934 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 290399012935 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 290399012936 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 290399012937 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 290399012938 tetramer interface [polypeptide binding]; other site 290399012939 active site 290399012940 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 290399012941 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 290399012942 active site 290399012943 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 290399012944 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 290399012945 active site 290399012946 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290399012947 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 290399012948 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 290399012949 active site 290399012950 Fe binding site [ion binding]; other site 290399012951 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 290399012952 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290399012953 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290399012954 shikimate binding site; other site 290399012955 NAD(P) binding site [chemical binding]; other site 290399012956 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 290399012957 Transcriptional regulator [Transcription]; Region: IclR; COG1414 290399012958 Bacterial transcriptional regulator; Region: IclR; pfam01614 290399012959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012960 metabolite-proton symporter; Region: 2A0106; TIGR00883 290399012961 putative substrate translocation pore; other site 290399012962 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 290399012963 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 290399012964 active site 290399012965 DNA binding site [nucleotide binding] 290399012966 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 290399012967 DNA binding site [nucleotide binding] 290399012968 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 290399012969 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 290399012970 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 290399012971 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 290399012972 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 290399012973 ligand binding site [chemical binding]; other site 290399012974 homodimer interface [polypeptide binding]; other site 290399012975 NAD(P) binding site [chemical binding]; other site 290399012976 trimer interface B [polypeptide binding]; other site 290399012977 trimer interface A [polypeptide binding]; other site 290399012978 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 290399012979 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 290399012980 trehalose synthase; Region: treS_nterm; TIGR02456 290399012981 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 290399012982 active site 290399012983 catalytic site [active] 290399012984 Ubiquitin-like proteins; Region: UBQ; cl00155 290399012985 charged pocket; other site 290399012986 hydrophobic patch; other site 290399012987 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290399012988 Ligand Binding Site [chemical binding]; other site 290399012989 DinB superfamily; Region: DinB_2; pfam12867 290399012990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290399012991 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 290399012992 putative homodimer interface [polypeptide binding]; other site 290399012993 putative homotetramer interface [polypeptide binding]; other site 290399012994 putative allosteric switch controlling residues; other site 290399012995 putative metal binding site [ion binding]; other site 290399012996 putative homodimer-homodimer interface [polypeptide binding]; other site 290399012997 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 290399012998 metal-binding site [ion binding] 290399012999 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290399013000 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290399013001 metal-binding site [ion binding] 290399013002 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290399013003 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290399013004 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 290399013005 EamA-like transporter family; Region: EamA; pfam00892 290399013006 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 290399013007 CGNR zinc finger; Region: zf-CGNR; pfam11706 290399013008 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 290399013009 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 290399013010 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290399013011 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290399013012 replicative DNA helicase; Region: DnaB; TIGR00665 290399013013 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290399013014 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 290399013015 Walker A motif; other site 290399013016 ATP binding site [chemical binding]; other site 290399013017 Walker B motif; other site 290399013018 DNA binding loops [nucleotide binding] 290399013019 hypothetical protein; Provisional; Region: PRK06771 290399013020 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 290399013021 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290399013022 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 290399013023 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 290399013024 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 290399013025 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 290399013026 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 290399013027 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 290399013028 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290399013029 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290399013030 dimer interface [polypeptide binding]; other site 290399013031 ssDNA binding site [nucleotide binding]; other site 290399013032 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290399013033 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 290399013034 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 290399013035 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 290399013036 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290399013037 putative homodimer interface [polypeptide binding]; other site 290399013038 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 290399013039 Chain length determinant protein; Region: Wzz; cl15801 290399013040 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 290399013041 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 290399013042 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 290399013043 active site 290399013044 metal binding site [ion binding]; metal-binding site 290399013045 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 290399013046 putative active site [active] 290399013047 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 290399013048 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290399013049 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290399013050 putative dimer interface [polypeptide binding]; other site 290399013051 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 290399013052 Spore germination protein; Region: Spore_permease; cl17796 290399013053 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399013054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399013055 active site 290399013056 phosphorylation site [posttranslational modification] 290399013057 intermolecular recognition site; other site 290399013058 dimerization interface [polypeptide binding]; other site 290399013059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399013060 DNA binding residues [nucleotide binding] 290399013061 dimerization interface [polypeptide binding]; other site 290399013062 Histidine kinase; Region: HisKA_3; pfam07730 290399013063 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 290399013064 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 290399013065 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290399013066 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 290399013067 Walker A/P-loop; other site 290399013068 ATP binding site [chemical binding]; other site 290399013069 Q-loop/lid; other site 290399013070 ABC transporter signature motif; other site 290399013071 Walker B; other site 290399013072 D-loop; other site 290399013073 H-loop/switch region; other site 290399013074 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 290399013075 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290399013076 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 290399013077 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 290399013078 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 290399013079 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290399013080 FAD binding domain; Region: FAD_binding_4; pfam01565 290399013081 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290399013082 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 290399013083 L-lactate permease; Region: Lactate_perm; cl00701 290399013084 Transcriptional regulators [Transcription]; Region: FadR; COG2186 290399013085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 290399013086 DNA-binding site [nucleotide binding]; DNA binding site 290399013087 FCD domain; Region: FCD; pfam07729 290399013088 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290399013089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290399013090 Walker A/P-loop; other site 290399013091 ATP binding site [chemical binding]; other site 290399013092 Q-loop/lid; other site 290399013093 ABC transporter signature motif; other site 290399013094 Walker B; other site 290399013095 D-loop; other site 290399013096 H-loop/switch region; other site 290399013097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290399013098 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 290399013099 active site 290399013100 S-layer homology domain; Region: SLH; pfam00395 290399013101 S-layer homology domain; Region: SLH; pfam00395 290399013102 S-layer homology domain; Region: SLH; pfam00395 290399013103 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 290399013104 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290399013105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290399013106 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 290399013107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290399013108 active site 290399013109 phosphorylation site [posttranslational modification] 290399013110 intermolecular recognition site; other site 290399013111 dimerization interface [polypeptide binding]; other site 290399013112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 290399013113 DNA binding residues [nucleotide binding] 290399013114 dimerization interface [polypeptide binding]; other site 290399013115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290399013116 Histidine kinase; Region: HisKA_3; pfam07730 290399013117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290399013118 ATP binding site [chemical binding]; other site 290399013119 G-X-G motif; other site 290399013120 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290399013121 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290399013122 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290399013123 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290399013124 Walker A/P-loop; other site 290399013125 ATP binding site [chemical binding]; other site 290399013126 Q-loop/lid; other site 290399013127 ABC transporter signature motif; other site 290399013128 Walker B; other site 290399013129 D-loop; other site 290399013130 H-loop/switch region; other site 290399013131 Predicted transcriptional regulators [Transcription]; Region: COG1733 290399013132 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 290399013133 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 290399013134 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290399013135 NAD binding site [chemical binding]; other site 290399013136 substrate binding site [chemical binding]; other site 290399013137 putative active site [active] 290399013138 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 290399013139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290399013140 Predicted integral membrane protein [Function unknown]; Region: COG5650 290399013141 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290399013142 catalytic core [active] 290399013143 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 290399013144 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290399013145 active site 290399013146 NTP binding site [chemical binding]; other site 290399013147 metal binding triad [ion binding]; metal-binding site 290399013148 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290399013149 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290399013150 Zn2+ binding site [ion binding]; other site 290399013151 Mg2+ binding site [ion binding]; other site 290399013152 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 290399013153 active site 290399013154 Ap6A binding site [chemical binding]; other site 290399013155 nudix motif; other site 290399013156 metal binding site [ion binding]; metal-binding site 290399013157 integral membrane protein MviN; Region: mviN; TIGR01695 290399013158 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 290399013159 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290399013160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290399013161 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290399013162 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290399013163 catalytic residues [active] 290399013164 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 290399013165 ParB-like nuclease domain; Region: ParBc; pfam02195 290399013166 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290399013167 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290399013168 Magnesium ion binding site [ion binding]; other site 290399013169 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 290399013170 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 290399013171 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 290399013172 G-X-X-G motif; other site 290399013173 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 290399013174 RxxxH motif; other site 290399013175 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 290399013176 Haemolytic domain; Region: Haemolytic; pfam01809 290399013177 Ribonuclease P; Region: Ribonuclease_P; pfam00825 290399013178 Ribosomal protein L34; Region: Ribosomal_L34; cl00370