-- dump date 20140618_194023 -- class Genbank::misc_feature -- table misc_feature_note -- id note 316275000001 TraY domain; Region: TraY; pfam05509 316275000002 type IV conjugative transfer system pilin TraA; Region: TraA_TIGR; TIGR02758 316275000004 TraL protein; Region: TraL; cl06278 316275000005 HMMPfam hit to PF07178, TraL protein, score 8.8e-36 316275000007 TraE protein; Region: TraE; cl05060 316275000008 HMMPfam hit to PF05309, TraE protein, score 2.9e-07 316275000010 TraK protein; Region: TraK; pfam06586 316275000011 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 316275000012 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 316275000014 HMMPfam hit to PF06447, TraB pilus assembly protein, score 6.7e-104 316275000015 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 316275000016 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275000017 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 316275000018 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 316275000019 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000020 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 316275000021 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275000023 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 316275000024 TraU protein; Region: TraU; cl06067 316275000025 HMMPfam hit to PF06834, TraU protein, score 1.3e-132 316275000026 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 316275000027 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 316275000028 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 316275000029 F plasmid transfer operon protein; Region: TraF; pfam13728 316275000031 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316275000032 catalytic residues [active] 316275000033 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 316275000034 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 316275000035 HMMPfam hit to PF06122, TraH protein, score 6e-152 316275000036 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 316275000037 HMMPfam hit to PF07916, TraG-like protein,N-terminal region, score 8.6e-173 316275000039 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000040 type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759 316275000041 F sex factor protein N terminal; Region: TraD_N; pfam12615 316275000042 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 316275000043 multimer interface [polypeptide binding]; other site 316275000044 Walker A motif; other site 316275000045 ATP binding site [chemical binding]; other site 316275000046 Walker B motif; other site 316275000048 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000049 conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760 316275000050 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 316275000051 AAA domain; Region: AAA_30; pfam13604 316275000052 CHC2 zinc finger; Region: zf-CHC2; cl17510 316275000053 Toprim domain; Region: Toprim_3; pfam13362 316275000054 Predicted helix-turn-helix motif with score 1070.000, SD 2.83 at aa 953-974, sequence ISKEDIIDTLKNNQETLSSEFS 316275000055 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000056 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000057 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 316275000058 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275000059 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275000060 catalytic residue [active] 316275000061 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 7e-27 316275000062 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 316275000063 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 316275000064 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275000065 HMMPfam hit to PF08401, Domain of unknown function (DUF1738), score 1.9e-60 316275000066 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316275000067 IHF dimer interface [polypeptide binding]; other site 316275000068 IHF - DNA interface [nucleotide binding]; other site 316275000069 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 2e-47 316275000070 Predicted helix-turn-helix motif with score 1169.000, SD 3.17 at aa 41-62, sequence LSQQEATAALNATVESITNALK 316275000071 PS00045 Bacterial histone-like DNA-binding proteins signature. 316275000072 Predicted helix-turn-helix motif with score 1259.000, SD 3.47 at aa 24-45, sequence ITSTEVIRAFGLGRQKISSLFT 316275000073 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 316275000074 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 316275000075 MPN+ (JAMM) motif; other site 316275000076 Zinc-binding site [ion binding]; other site 316275000077 HMMPfam hit to PF04002, RadC, DNA repair protein,score 1.5e-59 316275000078 PS01302 DNA repair protein radC family signature. 316275000079 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 316275000080 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 4.2e-73 316275000081 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 316275000082 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 316275000083 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 316275000084 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 9e-50 316275000085 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 316275000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275000087 HMMPfam hit to PF01476, LysM domain, score 5e-06 316275000088 PS01125 ROK family signature. 316275000089 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316275000090 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316275000091 HMMPfam hit to PF03781, Domain of unknown function (DUF323), score 5.6e-12 316275000092 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275000093 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316275000094 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275000095 P-loop; other site 316275000096 Magnesium ion binding site [ion binding]; other site 316275000097 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275000098 Magnesium ion binding site [ion binding]; other site 316275000099 plasmid-partitioning protein; Provisional; Region: PRK13698 316275000100 ParB-like nuclease domain; Region: ParBc; cl02129 316275000101 Predicted helix-turn-helix motif with score 1088.000, SD 2.89 at aa 181-202, sequence NNPTQLATALGLNRGLVSECLK 316275000102 multiple promoter invertase; Provisional; Region: mpi; PRK13413 316275000103 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 316275000104 catalytic residues [active] 316275000105 catalytic nucleophile [active] 316275000106 Presynaptic Site I dimer interface [polypeptide binding]; other site 316275000107 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 316275000108 Synaptic Flat tetramer interface [polypeptide binding]; other site 316275000109 Synaptic Site I dimer interface [polypeptide binding]; other site 316275000110 DNA binding site [nucleotide binding] 316275000111 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 316275000112 HMMPfam hit to PF02796, Helix-turn-helix domain of resolvase, score 1e-07 316275000113 Predicted helix-turn-helix motif with score 1695.000, SD 4.96 at aa 158-179, sequence MNKNAISKELGCSRTTVYSILN 316275000114 HMMPfam hit to PF00239, Resolvase, N terminal domain, score 3.2e-43 316275000115 PS00397 Site-specific recombinases active site. 316275000116 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 316275000117 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 316275000118 catalytic residues [active] 316275000119 catalytic nucleophile [active] 316275000120 Predicted helix-turn-helix motif with score 1541.000, SD 4.44 at aa 181-202, sequence LSINSTAKLVGVSARTVIRIVK 316275000121 HMMPfam hit to PF00239, Resolvase, N terminal domain, score 2.7e-22 316275000122 PS00398 Site-specific recombinases signature 2. 316275000123 PS00397 Site-specific recombinases active site. 316275000124 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000125 Putative transposase; Region: Y2_Tnp; pfam04986 316275000126 HMMPfam hit to PF04986, Putative transposase, score 2.7e-34 316275000127 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275000128 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316275000129 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316275000130 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000131 HMMPfam hit to PF01476, LysM domain, score 6.1e-14 316275000132 HMMPfam hit to PF01471, Putative peptidoglycan binding domain, score 1.5e-07 316275000133 Abi-like protein; Region: Abi_2; cl01988 316275000134 HMMPfam hit to PF07512, Protein of unknown function (DUF1526), score 1.1e-07 316275000135 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 316275000136 active site 316275000137 NTP binding site [chemical binding]; other site 316275000138 metal binding triad [ion binding]; metal-binding site 316275000139 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 316275000141 DDE domain; Region: DDE_Tnp_IS240; pfam13610 316275000142 Integrase core domain; Region: rve; pfam00665 316275000143 PS00213 Lipocalin signature. 316275000144 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 316275000145 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 8.3e-12 316275000146 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 316275000147 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 316275000148 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N terminal, score 4.3e-09 316275000150 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 316275000151 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000152 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316275000153 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316275000154 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000155 Protein of unknown function, DUF258; Region: DUF258; pfam03193 316275000156 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316275000157 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 316275000158 Switch II region; other site 316275000159 G4 box; other site 316275000160 G5 box; other site 316275000161 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000162 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275000163 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275000164 Integrase core domain; Region: rve; pfam00665 316275000165 HMMPfam hit to PF00665, Integrase core domain,score 2.9e-28 316275000166 Predicted helix-turn-helix motif with score 1352.000, SD 3.79 at aa 21-42, sequence VSMRAIARELERSPSSISRELG 316275000167 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 316275000168 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 316275000169 putative active site [active] 316275000170 putative metal binding site [ion binding]; other site 316275000171 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316275000172 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.2e-10 316275000173 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316275000174 IHF - DNA interface [nucleotide binding]; other site 316275000175 IHF dimer interface [polypeptide binding]; other site 316275000176 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.2e-40 316275000177 PS00045 Bacterial histone-like DNA-binding proteins signature. 316275000178 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000179 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 316275000180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275000181 NAD(P) binding site [chemical binding]; other site 316275000182 active site 316275000183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275000184 active site 316275000185 LytTr DNA-binding domain; Region: LytTR; smart00850 316275000187 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 316275000188 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 316275000189 ligand binding site [chemical binding]; other site 316275000191 FMN-binding protein MioC; Provisional; Region: PRK09004 316275000192 HMMPfam hit to PF00258, Flavodoxin, score 1.8e-24 316275000193 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 316275000194 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 316275000195 trmE is a tRNA modification GTPase; Region: trmE; cd04164 316275000196 G1 box; other site 316275000197 GTP/Mg2+ binding site [chemical binding]; other site 316275000198 Switch I region; other site 316275000199 G2 box; other site 316275000200 Switch II region; other site 316275000201 G3 box; other site 316275000202 G4 box; other site 316275000203 G5 box; other site 316275000204 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 316275000205 HMMPfam hit to PF01926, GTPase of unknown function,score 6.3e-41 316275000206 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000207 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000208 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 316275000209 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 316275000210 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 316275000211 HMMPfam hit to PF02096, 60Kd inner membrane protein, score 8.2e-121 316275000213 ribonuclease P; Reviewed; Region: rnpA; PRK01732 316275000214 HMMPfam hit to PF00825, Ribonuclease P, score 6.8e-40 316275000215 PS00648 Bacterial ribonuclease P protein component signature. 316275000216 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 316275000217 HMMPfam hit to PF00468, Ribosomal protein L34,score 9.9e-19 316275000218 PS00784 Ribosomal protein L34 signature. 316275000219 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 316275000220 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 316275000221 Walker A/P-loop; other site 316275000222 ATP binding site [chemical binding]; other site 316275000223 Q-loop/lid; other site 316275000224 ABC transporter signature motif; other site 316275000225 Walker B; other site 316275000226 D-loop; other site 316275000227 H-loop/switch region; other site 316275000228 HMMPfam hit to PF00005, ABC transporter score 2.5e-62 316275000229 PS00211 ABC transporters family signature. 316275000230 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275000232 dimer interface [polypeptide binding]; other site 316275000233 conserved gate region; other site 316275000234 putative PBP binding loops; other site 316275000235 ABC-ATPase subunit interface; other site 316275000236 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.5e-19 316275000238 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275000239 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275000240 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316275000241 substrate binding pocket [chemical binding]; other site 316275000242 membrane-bound complex binding site; other site 316275000243 hinge residues; other site 316275000244 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.6e-75 316275000245 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 316275000246 DnaA N-terminal domain; Region: DnaA_N; pfam11638 316275000247 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 316275000248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275000249 Walker A motif; other site 316275000250 ATP binding site [chemical binding]; other site 316275000251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 316275000252 Walker B motif; other site 316275000253 arginine finger; other site 316275000254 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 316275000255 DnaA box-binding interface [nucleotide binding]; other site 316275000256 HMMPfam hit to PF00308, Bacterial dnaA protein,score 1.4e-145 316275000257 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000258 HMMPfam hit to PF08299, Bacterial dnaA protein helix-turn-helix, score 2.9e-48 316275000259 PS01008 DnaA protein signature. 316275000260 DNA polymerase III subunit beta; Validated; Region: PRK05643 316275000261 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 316275000262 putative DNA binding surface [nucleotide binding]; other site 316275000263 dimer interface [polypeptide binding]; other site 316275000264 beta-clamp/clamp loader binding surface; other site 316275000265 beta-clamp/translesion DNA polymerase binding surface; other site 316275000266 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 4e-57 316275000267 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 0.00024 316275000268 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 1.2e-52 316275000269 recombination protein F; Reviewed; Region: recF; PRK00064 316275000270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275000271 Walker A/P-loop; other site 316275000272 ATP binding site [chemical binding]; other site 316275000273 Q-loop/lid; other site 316275000274 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275000275 ABC transporter signature motif; other site 316275000276 Walker B; other site 316275000277 D-loop; other site 316275000278 H-loop/switch region; other site 316275000279 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 1.3e-38 316275000280 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000281 PS00618 RecF protein signature 2. 316275000282 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 316275000283 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 316275000284 Mg2+ binding site [ion binding]; other site 316275000285 G-X-G motif; other site 316275000286 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 316275000287 anchoring element; other site 316275000288 dimer interface [polypeptide binding]; other site 316275000289 ATP binding site [chemical binding]; other site 316275000290 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 316275000291 active site 316275000292 putative metal-binding site [ion binding]; other site 316275000293 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 316275000294 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 6.7e-31 316275000295 HMMPfam hit to PF00204, DNA gyrase B, score 2.4e-92 316275000296 HMMPfam hit to PF01751, Toprim domain, score 2.1e-06 316275000297 PS00177 DNA topoisomerase II signature. 316275000298 HMMPfam hit to PF00986, DNA gyrase B subunit,carboxyl terminus, score 4.7e-45 316275000299 transposase (pseudogene);Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=2.3e-66, 54.1% id in 296 aa. CDS is disrupted by the insertion of an IS element 316275000300 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000301 Putative transposase; Region: Y2_Tnp; pfam04986 316275000302 HMMPfam hit to PF03050, Transposase IS66 family,score 1.4e-30 316275000303 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275000304 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275000305 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 316275000306 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 316275000307 ring oligomerisation interface [polypeptide binding]; other site 316275000308 ATP/Mg binding site [chemical binding]; other site 316275000309 stacking interactions; other site 316275000310 hinge regions; other site 316275000311 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 9.5e-194 316275000312 PS00296 Chaperonins cpn60 signature. 316275000313 PS00284 Serpins signature. 316275000314 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 316275000315 oligomerisation interface [polypeptide binding]; other site 316275000316 mobile loop; other site 316275000317 roof hairpin; other site 316275000318 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit,score 3e-36 316275000319 PS00681 Chaperonins cpn10 signature. 316275000320 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000321 Putative transposase; Region: Y2_Tnp; pfam04986 316275000322 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 316275000323 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 316275000324 HMMPfam hit to PF08401, Domain of unknown function (DUF1738), score 2.3e-68 316275000325 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000326 Putative transposase; Region: Y2_Tnp; pfam04986 316275000327 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 316275000328 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3.8e-05 316275000329 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 316275000330 putative active site [active] 316275000331 putative metal binding residues [ion binding]; other site 316275000332 signature motif; other site 316275000333 putative triphosphate binding site [ion binding]; other site 316275000334 dimer interface [polypeptide binding]; other site 316275000335 HMMPfam hit to PF01928, CYTH domain, score 3.1e-26 316275000336 PS00284 Serpins signature. 316275000337 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 316275000338 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 316275000339 LabA_like proteins; Region: LabA_like; cd06167 316275000340 putative metal binding site [ion binding]; other site 316275000341 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 316275000342 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 316275000343 HMMPfam hit to PF04754, transposase,YhgA-like, score 1.2e-176 316275000344 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275000345 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 316275000346 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316275000347 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000348 HMMPfam hit to PF01476, LysM domain, score 1.9e-14 316275000349 HMMPfam hit to PF01471, peptidoglycan binding domain, score 6.9e-08 316275000350 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000351 Putative transposase; Region: Y2_Tnp; pfam04986 316275000352 Similar to C-terminal part of Vibrio cholerae Toxin coregulated pilus biosynthesis protein I TcpI UniProt:P29486 (620 aa) fasta scores: E()=1.4e-24, 46.552% id in 232 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events; toxin coregulated pilus biosynthesis protein I (Tcp pilus biosynthesis protein TcpI) (fragment) 316275000353 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.4e-40 316275000354 Similar to Shewanella frigidimarina ncimb 400 Hypothetical protein precursor UniProt:Q3NML9 (287 aa) fasta scores: E()=2.8e-36, 56.614% id in 189 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275000355 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275000356 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275000357 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275000358 putative transposase; Provisional; Region: PRK09857 316275000359 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 316275000360 HMMPfam hit to PF04754, transposase,YhgA-like, score 3.7e-173 316275000361 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000362 Putative transposase; Region: Y2_Tnp; pfam04986 316275000363 Similar to Escherichia coli Acetolactate synthase isozyme II large subunit IlvG UniProt:P00892 (548 aa) fasta scores: E()=9.5e-32, 77.500% id in 120 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events (fragment); acetolactate synthase isozyme II large subunit 316275000364 PS00044 Bacterial regulatory proteins, lysR family signature. 316275000365 Predicted helix-turn-helix motif with score 987.000, SD 2.55 at aa 46-67, sequence HEQGAAMAAIGMARSTKSVAVC 316275000366 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 316275000367 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 316275000368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275000369 Walker A motif; other site 316275000370 ATP binding site [chemical binding]; other site 316275000371 Walker B motif; other site 316275000372 arginine finger; other site 316275000373 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 316275000374 HMMPfam hit to PF01078, Magnesium chelatase,subunit ChlI, score 2.1e-138 316275000375 HMMPfam hit to PF07728, ATPase family associated with various ce, score 3.9e-05 316275000376 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000377 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275000378 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316275000379 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 316275000380 putative acyl-acceptor binding pocket; other site 316275000382 HMMPfam hit to PF01553, Acyltransferase, score 7.9e-18 316275000383 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 316275000384 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 316275000385 catalytic residues [active] 316275000386 hinge region; other site 316275000387 alpha helical domain; other site 316275000388 HMMPfam hit to PF01323, DSBA-like thioredoxin domain, score 4.6e-30 316275000390 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 316275000391 serine/threonine protein kinase; Provisional; Region: PRK11768 316275000392 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 5.1e-34 316275000393 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 316275000394 4Fe-4S binding domain; Region: Fer4_5; pfam12801 316275000395 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 316275000396 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 316275000398 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0013 316275000399 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275000400 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 316275000401 HMMPfam hit to PF06288, Protein of unknown function (DUF1040), score 1.3e-47 316275000402 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 316275000403 SpoOM protein; Region: Spo0M; pfam07070 316275000404 HMMPfam hit to PF07070, SpoOM protein, score 5.7e-113 316275000405 hemolysin; Provisional; Region: PRK15087 316275000406 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 316275000407 HMMPfam hit to PF03006, Haemolysin-III related,score 5.2e-58 316275000409 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000410 Putative transposase; Region: Y2_Tnp; pfam04986 316275000411 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316275000412 DNA-binding site [nucleotide binding]; DNA binding site 316275000413 RNA-binding motif; other site 316275000414 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 8.9e-40 316275000415 PS00352 'Cold-shock' DNA-binding domain signature. 316275000416 threonine dehydratase; Reviewed; Region: PRK09224 316275000417 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 316275000418 tetramer interface [polypeptide binding]; other site 316275000419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275000420 catalytic residue [active] 316275000421 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 316275000422 putative Ile/Val binding site [chemical binding]; other site 316275000423 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 316275000424 putative Ile/Val binding site [chemical binding]; other site 316275000425 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 2.8e-38 316275000426 HMMPfam hit to PF00585, C-terminal regulatory domain of Threon, score 4.6e-39 316275000427 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 4.8e-101 316275000428 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 316275000429 Dehydratase family; Region: ILVD_EDD; cl00340 316275000430 Dehydratase family; Region: ILVD_EDD; cl00340 316275000431 HMMPfam hit to PF00920, Dehydratase family, score 4.3e-259 316275000432 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 316275000433 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000434 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 316275000435 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 316275000436 HMMPfam hit to PF01842, ACT domain, score 0.0058 316275000437 Similar to Escherichia coli Acetolactate synthase isozyme II large subunit IlvG UniProt:P00892 (548 aa) fasta scores: E()=1.5e-100, 62.383% id in 428 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275000438 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 2.8e-68 316275000439 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000440 PS00187 Thiamine pyrophosphate enzymes signature. 316275000441 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 8.8e-49 316275000442 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000443 Putative transposase; Region: Y2_Tnp; pfam04986 316275000444 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316275000445 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275000446 P-loop; other site 316275000447 Magnesium ion binding site [ion binding]; other site 316275000448 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275000449 Magnesium ion binding site [ion binding]; other site 316275000450 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 1.2e-27 316275000451 ParB-like nuclease domain; Region: ParB; smart00470 316275000452 KorB domain; Region: KorB; pfam08535 316275000453 HMMPfam hit to PF02195, ParB-like nuclease domain,score 1.9e-05 316275000454 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 316275000455 Similar to Photobacterium profundum Hypothetical protein SA0089 UniProt:Q6LUB5 (478 aa) fasta scores: E()=4.6e-147, 78.319% id in 452 aa. CDS contains a frameshift after codon 366. The sequence has been checked and is believed to be correct 316275000457 No significant database matches. CDS is probably truncated by the insertion of the downstream IS element and subsequent recombination events 316275000458 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275000459 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275000460 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 7.1e-42 316275000461 Similar to central part of Erwinia chrysanthemi Hemolysin/hemagglutinin-like protein HecA UniProt:P94772 (3848 aa) fasta scores: E()=3.9e-08, 28.864% id in 440 aa. CDS is truncated by the insertion of the upstream and downstream IS elements and subsequent recombination events 316275000462 HMMPfam hit to PF05594, Haemagluttinin repeat,score 0.36 316275000463 HMMPfam hit to PF05594, Haemagluttinin repeat,score 0.68 316275000464 HMMPfam hit to PF05594, Haemagluttinin repeat,score 3.5 316275000465 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=2.2e-119, 56.7% id in 494 aa. CDS contains a frameshift after codon 97 316275000466 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275000467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275000468 The insertion of the downstream IS element truncates the original translational stop codon of the CDS. There is an inframe translational stop codon 8 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275000469 HMMPfam hit to PF02386, Cation transport protein,score 1.6e-85 316275000471 PS00217 Sugar transport proteins signature 2. 316275000472 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 316275000473 TrkA-N domain; Region: TrkA_N; pfam02254 316275000474 TrkA-C domain; Region: TrkA_C; pfam02080 316275000475 TrkA-N domain; Region: TrkA_N; pfam02254 316275000476 TrkA-C domain; Region: TrkA_C; pfam02080 316275000477 HMMPfam hit to PF02080, TrkA-C domain, score 7.3e-10 316275000478 HMMPfam hit to PF03807, NADP oxidoreductase coenzyme F420-depen, score 0.0038 316275000479 HMMPfam hit to PF02254, TrkA-N domain, score 5.2e-34 316275000480 HMMPfam hit to PF02080, TrkA-C domain, score 4.2e-10 316275000481 HMMPfam hit to PF02254, TrkA-N domain, score 3.6e-36 316275000482 16S rRNA methyltransferase B; Provisional; Region: PRK10901 316275000483 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 316275000484 putative RNA binding site [nucleotide binding]; other site 316275000485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275000486 S-adenosylmethionine binding site [chemical binding]; other site 316275000487 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 9.2e-104 316275000488 PS01153 NOL1/NOP2/sun family signature. 316275000489 HMMPfam hit to PF01029, NusB family, score 1.7e-44 316275000490 PS00962 Ribosomal protein S2 signature 1. 316275000491 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 316275000492 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 316275000493 putative active site [active] 316275000494 substrate binding site [chemical binding]; other site 316275000495 putative cosubstrate binding site; other site 316275000496 catalytic site [active] 316275000497 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 316275000498 substrate binding site [chemical binding]; other site 316275000499 HMMPfam hit to PF02911, Formyl transferase,C-terminal domain, score 2.4e-38 316275000500 HMMPfam hit to PF00551, Formyl transferase, score 1.5e-63 316275000501 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 316275000502 active site 316275000503 catalytic residues [active] 316275000504 metal binding site [ion binding]; metal-binding site 316275000505 HMMPfam hit to PF01327, Polypeptide deformylase,score 2.9e-74 316275000506 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 316275000507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275000508 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 316275000509 HMMPfam hit to PF01476, LysM domain, score 7.1e-11 316275000510 hypothetical protein; Provisional; Region: PRK10736 316275000511 DNA protecting protein DprA; Region: dprA; TIGR00732 316275000512 HMMPfam hit to PF02481, SMF family, score 9.5e-93 316275000513 hypothetical protein; Validated; Region: PRK03430 316275000514 HMMPfam hit to PF04361, Protein of unknown function (DUF494), score 4.5e-94 316275000515 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316275000516 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316275000517 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316275000518 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 3.6e-16 316275000519 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 4.2e-17 316275000520 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 3.1e-09 316275000521 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 316275000522 ATP-grasp domain; Region: ATP-grasp; pfam02222 316275000523 HMMPfam hit to PF02222, ATP-grasp domain, score 3.9e-65 316275000524 AIR carboxylase; Region: AIRC; pfam00731 316275000525 HMMPfam hit to PF00731, AIR carboxylase, score 4.8e-92 316275000526 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 316275000527 HMMPfam hit to PF01300, yrdC domain, score 1.7e-55 316275000528 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 316275000529 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 316275000530 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 316275000531 shikimate binding site; other site 316275000532 NAD(P) binding site [chemical binding]; other site 316275000533 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate bind, score 3.4e-29 316275000534 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 7.2e-27 316275000535 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 316275000536 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 316275000537 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 316275000538 trimer interface [polypeptide binding]; other site 316275000539 putative metal binding site [ion binding]; other site 316275000540 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 14 316275000541 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4 316275000542 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 16 316275000543 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 63 316275000544 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 316275000545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275000546 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 316275000547 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 316275000548 putative dimerization interface [polypeptide binding]; other site 316275000549 HMMPfam hit to PF03466, LysR substrate binding domain, score 5e-24 316275000550 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.6e-17 316275000551 PS00044 Bacterial regulatory proteins, lysR family signature. 316275000552 Predicted helix-turn-helix motif with score 1546.000, SD 4.45 at aa 16-37, sequence HSFTNTSKAMHLSLSALSRQIQ 316275000553 ketol-acid reductoisomerase; Validated; Region: PRK05225 316275000554 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 316275000555 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 316275000556 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 316275000557 HMMPfam hit to PF07991, Acetohydroxy acid isomeroreductase, catalyti, score 9.4e-87 316275000558 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase, catalyti, score 1.2e-117 316275000559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 316275000560 HMMPfam hit to PF04380, Protein of unknown function (DUF526), score 7.9e-41 316275000561 multidrug efflux protein; Reviewed; Region: PRK09579 316275000562 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family,score 3.8e-283 316275000564 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275000565 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275000566 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00067 316275000568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275000569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275000570 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2.4e-18 316275000571 PS01081 Bacterial regulatory proteins, tetR family signature. 316275000572 Predicted helix-turn-helix motif with score 1736.000, SD 5.10 at aa 35-56, sequence LSMQKVANQAGVAAGTIYRYFD 316275000573 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 316275000574 Part of AAA domain; Region: AAA_19; pfam13245 316275000575 Family description; Region: UvrD_C_2; pfam13538 316275000576 HMMPfam hit to PF00580, UvrD/REP helicase, score 1e-211 316275000577 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000578 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 316275000579 HMMPfam hit to PF00034, Cytochrome c, score 0.018 316275000580 Similar to Vibrio fischeri Dipeptide transport ATP-binding protein DppD UniProt:Q5E1T2 (578 aa) fasta scores: E()=1e-173, 94.435% id in 575 aa. CDS contains a frameshift after codon 290. The sequence has been checked and is believed to be correct 316275000581 HMMPfam hit to PF00005, ABC transporter score 9.2e-58 316275000582 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000583 PS00211 ABC transporters family signature. 316275000584 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter C-termi, score 0.00011 316275000585 HMMPfam hit to PF00005, ABC transporter score 1.8e-69 316275000586 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000587 PS00211 ABC transporters family signature. 316275000588 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316275000589 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 316275000590 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 4e-80 316275000591 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 316275000592 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316275000593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275000594 dimer interface [polypeptide binding]; other site 316275000595 conserved gate region; other site 316275000596 putative PBP binding loops; other site 316275000597 ABC-ATPase subunit interface; other site 316275000599 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.1e-46 316275000600 dipeptide transporter; Provisional; Region: PRK10913 316275000601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275000602 dimer interface [polypeptide binding]; other site 316275000603 conserved gate region; other site 316275000604 putative PBP binding loops; other site 316275000605 ABC-ATPase subunit interface; other site 316275000607 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.8e-43 316275000608 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275000609 BCCT family transporter; Region: BCCT; pfam02028 316275000611 HMMPfam hit to PF02028, BCCT family transporterscore 8.4e-173 316275000612 PS01303 BCCT family of transporters signature. 316275000613 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 316275000614 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 316275000615 active site 316275000616 catalytic site [active] 316275000617 substrate binding site [chemical binding]; other site 316275000618 HMMPfam hit to PF00929, Exonuclease, score 9.3e-10 316275000619 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 316275000620 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316275000621 ligand binding site [chemical binding]; other site 316275000622 flexible hinge region; other site 316275000623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 316275000624 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316275000625 metal binding triad; other site 316275000626 HMMPfam hit to PF03445, nucleotidyltransferase DUF294, score 4e-114 316275000627 HMMPfam hit to PF00571, CBS domain pair, score 3e-29 316275000628 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 4e-16 316275000630 HTH domain; Region: HTH_11; pfam08279 316275000631 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 316275000632 Mga helix-turn-helix domain; Region: Mga; pfam05043 316275000633 PRD domain; Region: PRD; pfam00874 316275000634 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 316275000635 active site 316275000636 P-loop; other site 316275000637 phosphorylation site [posttranslational modification] 316275000638 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275000639 active site 316275000640 phosphorylation site [posttranslational modification] 316275000641 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 0.0019 316275000642 HMMPfam hit to PF00874, PRD domain, score 4.6e-10 316275000643 HMMPfam hit to PF05043, Mga helix-turn-helix domain, score 4.2e-06 316275000644 HMMPfam hit to PF08279, HTH domain, score 0.00019 316275000645 HMMPfam hit to PF08279, HTH domain, score 4.1e-12 316275000646 Predicted helix-turn-helix motif with score 1735.000, SD 5.10 at aa 37-58, sequence LPQQELAQRCDISTRTIRTDIS 316275000647 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 316275000648 HMMPfam hit to PF07071, Protein of unknown function (DUF1341), score 6e-144 316275000649 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 316275000650 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275000651 catalytic residue [active] 316275000652 HMMPfam hit to PF01212, Beta-eliminating lyase,score 7.3e-05 316275000653 dihydroorotase; Provisional; Region: PRK09237 316275000654 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 316275000655 active site 316275000656 HMMPfam hit to PF01979, Amidohydrolase family,score 0.00049 316275000657 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 316275000659 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 316275000661 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 316275000662 conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577 316275000663 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 316275000664 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275000665 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275000666 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275000667 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275000668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275000669 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275000670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275000671 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275000672 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275000673 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275000674 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 316275000675 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 316275000676 HMMPfam hit to PF07638, ECF sigma factor, score 1.3e-12 316275000677 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316275000678 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316275000679 active site 316275000680 ATP binding site [chemical binding]; other site 316275000681 substrate binding site [chemical binding]; other site 316275000682 activation loop (A-loop); other site 316275000684 HMMPfam hit to PF00069, Protein kinase domain,score 1e-25 316275000685 PS00108 Serine/Threonine protein kinases active-site signature. 316275000686 PS00107 Protein kinases ATP-binding region signature. 316275000687 glutathione reductase; Validated; Region: PRK06116 316275000688 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275000689 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275000690 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316275000691 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 2.6e-52 316275000692 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 5.8e-69 316275000693 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 3.5e-28 316275000694 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 316275000695 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 316275000696 HMMPfam hit to PF04378, Protein of unknown function (DUF519), score 1.4e-155 316275000697 PS00092 N-6 Adenine-specific DNA methylases signature. 316275000698 PS00092 N-6 Adenine-specific DNA methylases signature. 316275000699 oligopeptidase A; Provisional; Region: PRK10911 316275000700 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 316275000701 active site 316275000702 Zn binding site [ion binding]; other site 316275000703 Predicted helix-turn-helix motif with score 1024.000, SD 2.67 at aa 181-202, sequence KHITDEAELSGLPESAMSAAKA 316275000704 HMMPfam hit to PF01432, Peptidase family M3, score 3.3e-219 316275000705 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275000706 Peptidase family M48; Region: Peptidase_M48; pfam01435 316275000707 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 316275000708 HMMPfam hit to PF02743, Cache domain, score 3.4e-21 316275000709 HMMPfam hit to PF01435, Peptidase family M48, score 2.7e-27 316275000710 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 316275000711 putative iron binding site [ion binding]; other site 316275000712 HMMPfam hit to PF01491, Frataxin-like domain, score 1.2e-39 316275000713 diaminopimelate decarboxylase; Region: lysA; TIGR01048 316275000714 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 316275000715 active site 316275000716 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316275000717 substrate binding site [chemical binding]; other site 316275000718 catalytic residues [active] 316275000719 dimer interface [polypeptide binding]; other site 316275000720 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 1.7e-102 316275000721 PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 316275000722 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 316275000723 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 8.9e-33 316275000724 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 316275000725 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 316275000726 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 316275000727 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 4.3e-50 316275000728 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 1.9e-47 316275000729 Protein of unknown function, DUF484; Region: DUF484; cl17449 316275000730 HMMPfam hit to PF04340, Protein of unknown function, DUF484, score 3.5e-59 316275000731 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 316275000732 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275000733 active site 316275000734 DNA binding site [nucleotide binding] 316275000735 Int/Topo IB signature motif; other site 316275000736 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 3.5e-17 316275000737 HMMPfam hit to PF00589, Phage integrase family,score 4.7e-52 316275000738 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase (is66 family element,orf2-like). UniProt:Q3IIG1 (EMBL:CR954246) (115 aa) fasta scores: E()=1.1e-17, 65.2% id in 66 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275000739 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 3.7e-10 316275000740 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275000741 Putative transposase; Region: Y2_Tnp; pfam04986 316275000742 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275000743 GRASP55/65 PDZ-like domain; Region: GRASP55_65; pfam04495 316275000744 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 316275000745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275000746 catalytic residue [active] 316275000747 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 2.2e-42 316275000748 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 316275000749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275000750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 316275000751 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 316275000752 IucA / IucC family; Region: IucA_IucC; pfam04183 316275000753 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 316275000754 HMMPfam hit to PF04183, IucA / IucC family, score 9.2e-130 316275000755 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 316275000756 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 316275000757 N-terminal plug; other site 316275000758 ligand-binding site [chemical binding]; other site 316275000759 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 7.7e-16 316275000760 HMMPfam hit to PF00593, TonB dependent receptor,score 7.6e-24 316275000761 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 316275000762 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 316275000763 siderophore binding site; other site 316275000764 HMMPfam hit to PF01497, Periplasmic binding protein, score 7e-07 316275000765 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275000766 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316275000767 ABC-ATPase subunit interface; other site 316275000768 dimer interface [polypeptide binding]; other site 316275000769 putative PBP binding regions; other site 316275000771 HMMPfam hit to PF01032, FecCD transport family,score 1.3e-78 316275000772 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316275000773 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275000774 ABC-ATPase subunit interface; other site 316275000775 dimer interface [polypeptide binding]; other site 316275000776 putative PBP binding regions; other site 316275000778 HMMPfam hit to PF01032, FecCD transport family,score 2e-58 316275000779 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316275000780 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316275000781 Walker A/P-loop; other site 316275000782 ATP binding site [chemical binding]; other site 316275000783 Q-loop/lid; other site 316275000784 ABC transporter signature motif; other site 316275000785 Walker B; other site 316275000786 D-loop; other site 316275000787 H-loop/switch region; other site 316275000788 HMMPfam hit to PF00005, ABC transporter score 8.8e-50 316275000789 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000790 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275000791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275000792 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275000793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275000794 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275000795 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275000796 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275000797 Similar to Escherichia coli Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase GppA UniProt:P25552 (494 aa) fasta scores: E()=6.1e-48,51.935% id in 491 aa. CDS contains a frameshift after codon 213. The sequence has been checked and is believed to be correct 316275000798 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 316275000799 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275000800 ATP binding site [chemical binding]; other site 316275000801 Mg++ binding site [ion binding]; other site 316275000802 motif III; other site 316275000803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275000804 nucleotide binding region [chemical binding]; other site 316275000805 ATP-binding site [chemical binding]; other site 316275000806 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 8.5e-34 316275000807 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 2.3e-63 316275000808 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275000809 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000810 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316275000811 catalytic residues [active] 316275000812 HMMPfam hit to PF00085, Thioredoxin, score 2.2e-49 316275000813 PS00194 Thioredoxin family active site. 316275000814 transcription termination factor Rho; Provisional; Region: rho; PRK09376 316275000815 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 316275000816 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 316275000817 RNA binding site [nucleotide binding]; other site 316275000818 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 316275000819 multimer interface [polypeptide binding]; other site 316275000820 Walker A motif; other site 316275000821 ATP binding site [chemical binding]; other site 316275000822 Walker B motif; other site 316275000823 HMMPfam hit to PF07498, Rho termination factor,N-terminal domai, score 1.1e-19 316275000824 HMMPfam hit to PF07497, Rho termination factor,RNA-binding doma, score 5.6e-58 316275000825 HMMPfam hit to PF08206, Ribonuclease B OB domain,score 0.002 316275000826 PS00464 Ribosomal protein L22 signature. 316275000827 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 6.2e-74 316275000828 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000829 Ribosomal L29e protein family; Region: Ribosomal_L29e; cl15447 316275000830 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 316275000831 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 316275000832 HMMPfam hit to PF01977,3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 2.7e-200 316275000833 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316275000834 catalytic loop [active] 316275000835 iron binding site [ion binding]; other site 316275000836 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 8.1e-17 316275000837 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 316275000838 FMN reductase; Validated; Region: fre; PRK08051 316275000839 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 316275000840 FAD binding pocket [chemical binding]; other site 316275000841 FAD binding motif [chemical binding]; other site 316275000842 phosphate binding motif [ion binding]; other site 316275000843 beta-alpha-beta structure motif; other site 316275000844 NAD binding pocket [chemical binding]; other site 316275000845 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 7e-05 316275000846 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 5.2e-33 316275000847 PS00017 ATP/GTP-binding site motif A (P-loop). 316275000848 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.2e-119, 56.998% id in 493 aa. CDS contains a frameshift after codon 93 316275000849 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase (is66 family element,orf2-like). UniProt:Q3IIG1 (EMBL:CR954246) (115 aa) fasta scores: E()=3.3e-31,57.391% id in 115 aa. CDS contains a frameshift after codon 27 316275000850 Similar to C-terminal part of Serratia marcescens Phosphopantetheine adenylyltransferase CoaD UniProt:Q9X980 (161 aa) fasta scores: E()=7.7e-10, 61.111% id in 54 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275000851 Sulfatase; Region: Sulfatase; cl17466 316275000852 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 316275000853 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 316275000854 DNA binding site [nucleotide binding] 316275000855 catalytic residue [active] 316275000856 H2TH interface [polypeptide binding]; other site 316275000857 putative catalytic residues [active] 316275000858 turnover-facilitating residue; other site 316275000859 intercalation triad [nucleotide binding]; other site 316275000860 8OG recognition residue [nucleotide binding]; other site 316275000861 putative reading head residues; other site 316275000862 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 316275000863 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 316275000864 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 7.9e-47 316275000865 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 316275000866 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 316275000867 NADP binding site [chemical binding]; other site 316275000868 homopentamer interface [polypeptide binding]; other site 316275000869 substrate binding site [chemical binding]; other site 316275000870 active site 316275000871 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 9.3e-45 316275000872 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/isomera, score 3.9e-06 316275000873 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 316275000874 O-Antigen ligase; Region: Wzy_C; pfam04932 316275000875 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316275000876 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316275000877 putative active site [active] 316275000878 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 316275000879 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 316275000880 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316275000881 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275000882 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275000883 Integrase core domain; Region: rve; pfam00665 316275000884 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 316275000885 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 316275000886 Ligand Binding Site [chemical binding]; other site 316275000887 Similar to Escherichia coli NnaC UniProt:Q93NQ1 (421 aa) fasta scores: E()=3.8e-21, 42.130% id in 216 aa. CDS contains a nonsense mutation (TAG) after codon 45. The sequence has been checked and is believed to be correct 316275000888 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 316275000889 FOG: CBS domain [General function prediction only]; Region: COG0517 316275000890 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 316275000891 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316275000892 Substrate binding site; other site 316275000893 metal-binding site 316275000894 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 316275000895 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 316275000896 putative trimer interface [polypeptide binding]; other site 316275000897 putative CoA binding site [chemical binding]; other site 316275000898 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 316275000899 NeuB family; Region: NeuB; pfam03102 316275000900 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 316275000901 NeuB binding interface [polypeptide binding]; other site 316275000902 putative substrate binding site [chemical binding]; other site 316275000903 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 316275000904 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316275000905 active site 316275000906 homodimer interface [polypeptide binding]; other site 316275000907 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 316275000908 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316275000909 inhibitor-cofactor binding pocket; inhibition site 316275000910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275000911 catalytic residue [active] 316275000912 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 316275000913 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 316275000914 NAD(P) binding site [chemical binding]; other site 316275000915 homodimer interface [polypeptide binding]; other site 316275000916 substrate binding site [chemical binding]; other site 316275000917 active site 316275000918 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 316275000919 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316275000920 inhibitor-cofactor binding pocket; inhibition site 316275000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275000922 catalytic residue [active] 316275000923 Similar to Vibrio cholerae WavS UniProt:Q8RTH0 (222 aa) fasta scores: E()=3.6e-13, 39.161% id in 143 aa. CDS contains a nonsense mutation (TAA) after codon 152. The sequence has been checked and is believed to be correct 316275000924 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 316275000925 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 316275000926 Substrate binding site; other site 316275000927 metal-binding site 316275000928 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 316275000929 Similar to Vibrio cholerae DTDP-6-deoxy-L-mannose-dehydrogenase rmlD UniProt:Q842N3 (291 aa) fasta scores: E()=2.3e-59, 58.108% id in 296 aa. CDS contains two nonsense mutations (TAA) and (TAA) after codon 67. The sequence has been checked and is believed to be correct 316275000930 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 316275000931 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 316275000932 substrate binding site; other site 316275000933 tetramer interface; other site 316275000934 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 316275000935 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 316275000936 NAD binding site [chemical binding]; other site 316275000937 substrate binding site [chemical binding]; other site 316275000938 homodimer interface [polypeptide binding]; other site 316275000939 active site 316275000940 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 316275000941 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 316275000942 Sulfatase; Region: Sulfatase; cl17466 316275000943 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 316275000944 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 316275000945 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316275000946 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316275000947 putative active site [active] 316275000948 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316275000949 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 316275000950 putative metal binding site; other site 316275000951 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275000952 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316275000953 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 316275000954 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 316275000955 active site 316275000956 (T/H)XGH motif; other site 316275000957 HMMPfam hit to PF01467, Cytidylyltransferase, score 4e-36 316275000958 HMMPfam hit to PF08218, Citrate lyase ligase C-terminal domain, score 0.0044 316275000959 Sulfatase; Region: Sulfatase; cl17466 316275000960 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 316275000961 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 316275000962 DNA binding site [nucleotide binding] 316275000963 catalytic residue [active] 316275000964 H2TH interface [polypeptide binding]; other site 316275000965 putative catalytic residues [active] 316275000966 turnover-facilitating residue; other site 316275000967 intercalation triad [nucleotide binding]; other site 316275000968 8OG recognition residue [nucleotide binding]; other site 316275000969 putative reading head residues; other site 316275000970 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 316275000971 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 316275000972 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase N-, score 7.9e-47 316275000974 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 316275000975 PS00582 Ribosomal protein L33 signature. 316275000976 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 316275000977 hypothetical protein; Reviewed; Region: PRK00024 316275000978 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 316275000979 MPN+ (JAMM) motif; other site 316275000980 Zinc-binding site [ion binding]; other site 316275000981 HMMPfam hit to PF04002, RadC, DNA repair protein,score 1.8e-75 316275000982 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 316275000983 Flavoprotein; Region: Flavoprotein; pfam02441 316275000984 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 316275000985 HMMPfam hit to PF02441, Flavoprotein, score 1.9e-43 316275000986 HMMPfam hit to PF04127, DNA / pantothenate metabolism flavoprote, score 8e-44 316275000987 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275000988 division inhibitor protein; Provisional; Region: slmA; PRK09480 316275000989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275000990 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 8.7e-10 316275000991 Predicted helix-turn-helix motif with score 2248.000, SD 6.84 at aa 30-51, sequence ITTAKLAKQVGVSEAALYRHFP 316275000992 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 316275000993 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316275000994 putative acyl-acceptor binding pocket; other site 316275000995 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 6.9e-82 316275000997 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 316275000998 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 316275000999 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 316275001000 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 1.5e-38 316275001001 PS00829 Prokaryotic transcription elongation factors signature 1. 316275001002 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 6.6e-34 316275001003 PS00830 Prokaryotic transcription elongation factors signature 2. 316275001004 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 316275001005 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 316275001006 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 316275001007 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 316275001008 RNA binding site [nucleotide binding]; other site 316275001009 HMMPfam hit to PF00575, S1 RNA binding domain,score 5.6e-25 316275001010 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 316275001011 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 316275001012 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 2.7e-26 316275001013 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275001014 Similar to Escherichia coli Protein GntX UniProt:P46846 (227 aa) fasta scores: E()=4.9e-19, 35.398% id in 226 aa. CDS is disrupted by the insertion of an IS element after codon 95 316275001015 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275001016 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275001017 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275001018 Similar to Vibrio fischeri Xanthine permease UniProt:Q5E8N5 (463 aa) fasta scores: E()=1.2e-133,93.043% id in 460 aa. CDS contains a framshift after codon 115. The sequence has been checked and is believed to be correct 316275001019 HMMPfam hit to PF00860, Permease family, score 4.1e-130 316275001022 PS01116 Xanthine/uracil permeases family signature. 316275001023 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 316275001024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275001025 dimerization interface [polypeptide binding]; other site 316275001026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275001027 dimer interface [polypeptide binding]; other site 316275001028 phosphorylation site [posttranslational modification] 316275001029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275001030 ATP binding site [chemical binding]; other site 316275001031 Mg2+ binding site [ion binding]; other site 316275001032 G-X-G motif; other site 316275001033 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.4e-35 316275001034 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.1e-10 316275001035 HMMPfam hit to PF00672, HAMP domain, score 2.2e-12 316275001037 osmolarity response regulator; Provisional; Region: ompR; PRK09468 316275001038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275001039 active site 316275001040 phosphorylation site [posttranslational modification] 316275001041 intermolecular recognition site; other site 316275001042 dimerization interface [polypeptide binding]; other site 316275001043 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275001044 DNA binding site [nucleotide binding] 316275001045 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.7e-14 316275001046 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.7e-40 316275001047 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275001048 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316275001049 P-loop; other site 316275001050 Magnesium ion binding site [ion binding]; other site 316275001051 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316275001052 active site 316275001053 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 4.5e-32 316275001054 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 316275001055 ribonuclease PH; Reviewed; Region: rph; PRK00173 316275001056 Ribonuclease PH; Region: RNase_PH_bact; cd11362 316275001057 hexamer interface [polypeptide binding]; other site 316275001058 active site 316275001059 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 2.3e-18 316275001060 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 1.8e-57 316275001061 PS01277 Ribonuclease PH signature. 316275001062 hypothetical protein; Provisional; Region: PRK11820 316275001063 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 316275001064 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 316275001065 HMMPfam hit to PF03755, YicC-like family,N-terminal region, score 8.1e-75 316275001066 HMMPfam hit to PF08340, Domain of unknown function (DUF1732), score 4.1e-58 316275001067 HMMPfam hit to PF06146,Phosphate-starvation-inducible E, score 1.8e-58 316275001069 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 316275001070 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 316275001071 catalytic site [active] 316275001072 G-X2-G-X-G-K; other site 316275001073 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001074 PS00856 Guanylate kinase signature. 316275001075 HMMPfam hit to PF00625, Guanylate kinase, score 3.4e-47 316275001076 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 316275001077 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 2.2e-20 316275001078 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 316275001079 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275001080 Zn2+ binding site [ion binding]; other site 316275001081 Mg2+ binding site [ion binding]; other site 316275001082 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 316275001083 synthetase active site [active] 316275001084 NTP binding site [chemical binding]; other site 316275001085 metal binding site [ion binding]; metal-binding site 316275001086 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 316275001087 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 316275001088 HMMPfam hit to PF01966, HD domain, score 5.5e-16 316275001089 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 1.3e-43 316275001090 HMMPfam hit to PF02824, TGS domain, score 2.3e-26 316275001091 HMMPfam hit to PF01842, ACT domain, score 0.00013 316275001092 Similar to Escherichia coli tRNA guanosine-2'-O-methyltransferase TrmH UniProt:P0AGJ2 (229 aa) fasta scores: E()=1.1e-45, 68.783% id in 189 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275001093 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 2.6e-53 316275001094 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275001095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001096 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275001097 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275001098 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275001099 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275001100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001101 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 316275001102 HemY protein N-terminus; Region: HemY_N; pfam07219 316275001103 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.00091 316275001104 HMMPfam hit to PF07219, HemY protein N-terminus,score 1.6e-41 316275001106 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 316275001107 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 316275001108 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001109 HMMPfam hit to PF04375, HemX, score 7.3e-104 316275001111 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 316275001112 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 316275001113 active site 316275001114 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 5.5e-21 316275001115 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 316275001116 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 316275001117 domain interfaces; other site 316275001118 active site 316275001119 HMMPfam hit to PF03900, Porphobilinogen deaminase,C-terminal, score 6.6e-30 316275001120 PS00533 Porphobilinogen deaminase cofactor-binding site. 316275001121 HMMPfam hit to PF01379, Porphobilinogen deaminase,dipyrometh, score 8.5e-140 316275001122 adenylate cyclase; Provisional; Region: cyaA; PRK09450 316275001123 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 316275001124 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 316275001125 HMMPfam hit to PF01295, Adenylate cyclase, class-I,score 0 316275001126 PS01092 Adenylate cyclases class-I signature 1. 316275001127 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 316275001128 Part of AAA domain; Region: AAA_19; pfam13245 316275001129 Family description; Region: UvrD_C_2; pfam13538 316275001130 HMMPfam hit to PF00580, UvrD/REP helicase, score 1.8e-207 316275001131 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001132 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 316275001134 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275001135 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 9.3e-10 316275001136 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 316275001137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275001138 ATP binding site [chemical binding]; other site 316275001139 putative Mg++ binding site [ion binding]; other site 316275001140 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275001141 nucleotide binding region [chemical binding]; other site 316275001142 ATP-binding site [chemical binding]; other site 316275001143 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 316275001144 HRDC domain; Region: HRDC; pfam00570 316275001145 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 9.1e-34 316275001146 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 6.5e-28 316275001147 HMMPfam hit to PF00570, HRDC domain, score 5e-25 316275001148 Protein of unknown function (DUF3630); Region: DUF3630; pfam12305 316275001149 hypothetical protein; Provisional; Region: PRK11212 316275001151 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 4.8e-71 316275001152 DNA polymerase I; Provisional; Region: PRK05755 316275001153 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 316275001154 active site 316275001155 metal binding site 1 [ion binding]; metal-binding site 316275001156 putative 5' ssDNA interaction site; other site 316275001157 metal binding site 3; metal-binding site 316275001158 metal binding site 2 [ion binding]; metal-binding site 316275001159 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 316275001160 putative DNA binding site [nucleotide binding]; other site 316275001161 putative metal binding site [ion binding]; other site 316275001162 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 316275001163 active site 316275001164 catalytic site [active] 316275001165 substrate binding site [chemical binding]; other site 316275001166 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 316275001167 active site 316275001168 DNA binding site [nucleotide binding] 316275001169 catalytic site [active] 316275001170 HMMPfam hit to PF02739, 5'-3' exonuclease,N-terminal resolvase-, score 1.5e-87 316275001171 HMMPfam hit to PF01367, 5'-3' exonuclease,C-terminal SAM fold, score 4.2e-48 316275001172 HMMPfam hit to PF01612, 3'-5' exonuclease, score 7.1e-55 316275001173 HMMPfam hit to PF00476, DNA polymerase family A,score 3.2e-201 316275001174 PS00447 DNA polymerase family A signature. 316275001175 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 316275001176 G1 box; other site 316275001177 GTP/Mg2+ binding site [chemical binding]; other site 316275001178 Switch I region; other site 316275001179 G2 box; other site 316275001180 G3 box; other site 316275001181 Switch II region; other site 316275001182 G4 box; other site 316275001183 G5 box; other site 316275001184 HMMPfam hit to PF01926, GTPase of unknown function,score 3.2e-29 316275001185 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001186 Cytochrome c553 [Energy production and conversion]; Region: COG2863 316275001187 Cytochrome c; Region: Cytochrom_C; cl11414 316275001188 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275001189 HMMPfam hit to PF00034, Cytochrome c, score 1e-12 316275001190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316275001191 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316275001192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316275001193 Der GTPase activator; Provisional; Region: PRK05244 316275001194 HMMPfam hit to PF04220, Protein of unknown function, DUF414, score 1.7e-47 316275001195 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 316275001197 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 316275001198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275001199 FeS/SAM binding site; other site 316275001200 HemN C-terminal domain; Region: HemN_C; pfam06969 316275001201 HMMPfam hit to PF04055, Radical SAM superfamily,score 1.5e-25 316275001202 HMMPfam hit to PF06969, HemN C-terminal region,score 9.2e-49 316275001203 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275001204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001205 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275001206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001207 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275001208 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275001209 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275001210 phosphopantetheine adenylyltransferase (fragment) 316275001211 HMMPfam hit to PF01467, Cytidylyltransferase, score 3.3e-12 316275001212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275001213 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316275001214 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 316275001215 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 316275001216 putative metal binding site; other site 316275001217 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316275001218 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316275001219 putative active site [active] 316275001220 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 316275001221 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293 316275001222 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 316275001223 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 316275001224 Sulfatase; Region: Sulfatase; cl17466 316275001225 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 316275001226 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 316275001227 NAD binding site [chemical binding]; other site 316275001228 substrate binding site [chemical binding]; other site 316275001229 homodimer interface [polypeptide binding]; other site 316275001230 active site 316275001231 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 316275001232 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 316275001233 substrate binding site; other site 316275001234 tetramer interface; other site 316275001235 Similar to Vibrio cholerae DTDP-6-deoxy-L-mannose-dehydrogenase rmlD UniProt:Q842N3 (291 aa) fasta scores: E()=2.3e-59, 58.108% id in 296 aa. CDS contains two nonsense mutations (TAA) and (TAA) after codon 67. The sequence has been checked and is believed to be correct 316275001236 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 316275001237 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 316275001238 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 316275001239 Substrate binding site; other site 316275001240 metal-binding site 316275001241 Similar to Vibrio cholerae WavS UniProt:Q8RTH0 (222 aa) fasta scores: E()=3.6e-13, 39.161% id in 143 aa. CDS contains a nonsense mutation (TAA) after codon 152. The sequence has been checked and is believed to be correct 316275001242 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 316275001243 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316275001244 inhibitor-cofactor binding pocket; inhibition site 316275001245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275001246 catalytic residue [active] 316275001247 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 316275001248 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 316275001249 NAD(P) binding site [chemical binding]; other site 316275001250 homodimer interface [polypeptide binding]; other site 316275001251 substrate binding site [chemical binding]; other site 316275001252 active site 316275001253 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 316275001254 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 316275001255 inhibitor-cofactor binding pocket; inhibition site 316275001256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275001257 catalytic residue [active] 316275001258 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 316275001259 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316275001260 active site 316275001261 homodimer interface [polypeptide binding]; other site 316275001262 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 316275001263 NeuB family; Region: NeuB; pfam03102 316275001264 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 316275001265 NeuB binding interface [polypeptide binding]; other site 316275001266 putative substrate binding site [chemical binding]; other site 316275001267 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 316275001268 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 316275001269 putative trimer interface [polypeptide binding]; other site 316275001270 putative CoA binding site [chemical binding]; other site 316275001271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 316275001272 FOG: CBS domain [General function prediction only]; Region: COG0517 316275001273 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 316275001274 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316275001275 Substrate binding site; other site 316275001276 metal-binding site 316275001277 Similar to Escherichia coli NnaC UniProt:Q93NQ1 (421 aa) fasta scores: E()=3.8e-21, 42.130% id in 216 aa. CDS contains a nonsense mutation (TAG) after codon 45. The sequence has been checked and is believed to be correct 316275001278 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 316275001279 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_III; cd01996 316275001280 Ligand Binding Site [chemical binding]; other site 316275001281 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275001282 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275001283 Integrase core domain; Region: rve; pfam00665 316275001284 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 316275001285 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 316275001286 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316275001287 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316275001288 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 316275001289 putative active site [active] 316275001290 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 316275001291 O-Antigen ligase; Region: Wzy_C; pfam04932 316275001292 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 316275001293 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 316275001294 NADP binding site [chemical binding]; other site 316275001295 homopentamer interface [polypeptide binding]; other site 316275001296 substrate binding site [chemical binding]; other site 316275001297 active site 316275001298 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/isomera, score 3.9e-06 316275001299 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 9.3e-45 316275001300 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 316275001301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316275001302 Beta-Casp domain; Region: Beta-Casp; smart01027 316275001303 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 316275001304 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 1.7e-18 316275001305 HMMPfam hit to PF07521, RNA-metabolising metallo-beta-lactamase, score 8.6e-15 316275001306 hypothetical protein; Reviewed; Region: PRK12275 316275001307 four helix bundle protein; Region: TIGR02436 316275001308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275001309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275001310 Bacterial transcriptional repressor; Region: TetR; pfam13972 316275001311 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 2e-13 316275001312 Predicted helix-turn-helix motif with score 1148.000, SD 3.10 at aa 23-44, sequence ITTNHISAHLEISPGNLYYHFG 316275001313 PS00904 Protein prenyltransferases alpha subunit repeat signature. 316275001314 Surface antigen; Region: Bac_surface_Ag; pfam01103 316275001315 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275001316 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 316275001317 HMMPfam hit to PF06082, Bacterial lipoprotein (DUF940), score 0 316275001318 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 316275001319 HMMPfam hit to PF06251, Protein of unknown function (DUF1017), score 4.9e-33 316275001320 Predicted helix-turn-helix motif with score 1038.000, SD 2.72 at aa 155-176, sequence TTITVLGLTLSPKPQTLSYIEN 316275001321 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 316275001322 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275001324 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 316275001326 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 316275001327 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 316275001328 SLBB domain; Region: SLBB; pfam10531 316275001329 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 316275001330 SLBB domain; Region: SLBB; pfam10531 316275001331 SLBB domain; Region: SLBB; pfam10531 316275001332 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 316275001333 SLBB domain; Region: SLBB; pfam10531 316275001334 HMMPfam hit to PF02563, Polysaccharide biosynthesis/export protei, score 3.8e-20 316275001335 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001336 Chain length determinant protein; Region: Wzz; pfam02706 316275001337 HMMPfam hit to PF02706, Chain length determinant protein, score 1.3e-23 316275001339 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275001340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001341 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.2e-119, 56.998% id in 493 aa. Contains a 31 nucleotide deletion after codon 73 316275001342 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 316275001343 putative active site [active] 316275001344 HMMPfam hit to PF04480, Protein of unknown function (DUF559), score 1.2e-35 316275001345 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 316275001346 substrate binding site [chemical binding]; other site 316275001347 dimer interface [polypeptide binding]; other site 316275001348 catalytic triad [active] 316275001349 HMMPfam hit to PF00121, Triosephosphate isomerase,score 1e-122 316275001350 PS00171 Triosephosphate isomerase active site. 316275001351 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 316275001352 putative substrate binding pocket [chemical binding]; other site 316275001353 trimer interface [polypeptide binding]; other site 316275001354 HMMPfam hit to PF02962,5-carboxymethyl-2-hydroxymuconate isomerase, score 2.4e-05 316275001355 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E8E3 (117 aa) fasta scores: E()=1.4e-26, 83.333% id in 90 aa. CDS is disrupted by the insertion of an IS element after codon 107 316275001356 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275001357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275001358 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275001359 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 316275001360 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 316275001361 putative active site [active] 316275001362 HMMPfam hit to PF03320, Bacterial fructose-1,6-bisphosphatase, gl, score 3.2e-213 316275001363 Protein of unknown function (DUF904); Region: DUF904; pfam06005 316275001364 HMMPfam hit to PF06005, Protein of unknown function (DUF904), score 4.4e-28 316275001365 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275001366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001367 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275001368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001369 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275001370 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275001371 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275001372 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 316275001373 HMMPfam hit to PF03737, Demethylmenaquinone methyltransferase, score 1.7e-77 316275001374 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 316275001375 UbiA prenyltransferase family; Region: UbiA; pfam01040 316275001376 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 1.2e-30 316275001378 phosphoribulokinase; Provisional; Region: PRK15453 316275001379 active site 316275001380 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 1.2e-101 316275001381 hypothetical protein; Provisional; Region: PRK04966 316275001382 HMMPfam hit to PF06794, Uncharacterised protein family (UPF0270), score 1.8e-38 316275001383 putative hydrolase; Provisional; Region: PRK10985 316275001384 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 1.5e-07 316275001385 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 316275001386 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 316275001387 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275001388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275001389 ABC transporter; Region: ABC_tran_2; pfam12848 316275001390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275001391 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 316275001392 HMMPfam hit to PF00005, ABC transporter score 3.8e-49 316275001393 PS00211 ABC transporters family signature. 316275001394 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001395 HMMPfam hit to PF00005, ABC transporter score 1.3e-43 316275001396 PS00211 ABC transporters family signature. 316275001397 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001398 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 316275001399 HMMPfam hit to PF02525, Flavodoxin-like fold, score 5.8e-56 316275001400 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 316275001401 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 316275001402 TrkA-N domain; Region: TrkA_N; pfam02254 316275001404 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 4.8e-74 316275001405 HMMPfam hit to PF02254, TrkA-N domain, score 8.8e-28 316275001406 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 316275001407 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 316275001408 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316275001409 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 8.2e-05 316275001410 PS00430 TonB-dependent receptor proteins signature 1. 316275001411 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 316275001412 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 316275001413 hypothetical protein; Provisional; Region: PRK04406 316275001414 HMMPfam hit to PF04102, SlyX, score 6.6e-31 316275001415 FOG: WD40 repeat [General function prediction only]; Region: COG2319 316275001416 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 316275001417 structural tetrad; other site 316275001418 PS00678 Trp-Asp (WD) repeats signature. 316275001419 HMMPfam hit to PF00400, WD domain, G-beta repeat,score 0.0011 316275001420 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275001421 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 316275001422 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 316275001423 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316275001424 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275001425 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 7.6e-28 316275001426 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 1e-47 316275001427 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 316275001428 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 316275001429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 316275001430 YheO-like PAS domain; Region: PAS_6; pfam08348 316275001431 HTH domain; Region: HTH_22; pfam13309 316275001432 HMMPfam hit to PF08348, YheO-like protein, score 6.3e-62 316275001433 Predicted helix-turn-helix motif with score 1246.000, SD 3.43 at aa 207-228, sequence DAINRVADQLNISKHTVYLYIR 316275001434 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 316275001435 HMMPfam hit to PF02635, DsrE/DsrF-like family,score 2.9e-46 316275001436 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 316275001437 HMMPfam hit to PF02635, DsrE/DsrF-like family,score 1.6e-31 316275001438 DsrH like protein; Region: DsrH; cl17347 316275001439 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 316275001440 S17 interaction site [polypeptide binding]; other site 316275001441 S8 interaction site; other site 316275001442 16S rRNA interaction site [nucleotide binding]; other site 316275001443 streptomycin interaction site [chemical binding]; other site 316275001444 23S rRNA interaction site [nucleotide binding]; other site 316275001445 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 316275001446 HMMPfam hit to PF00164, Ribosomal protein S12,score 1.3e-74 316275001447 PS00055 Ribosomal protein S12 signature. 316275001448 30S ribosomal protein S7; Validated; Region: PRK05302 316275001449 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e,score 7.5e-85 316275001450 PS00052 Ribosomal protein S7 signature. 316275001451 elongation factor G; Reviewed; Region: PRK00007 316275001452 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 316275001453 G1 box; other site 316275001454 putative GEF interaction site [polypeptide binding]; other site 316275001455 GTP/Mg2+ binding site [chemical binding]; other site 316275001456 Switch I region; other site 316275001457 G2 box; other site 316275001458 G3 box; other site 316275001459 Switch II region; other site 316275001460 G4 box; other site 316275001461 G5 box; other site 316275001462 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 316275001463 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 316275001464 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 316275001465 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2e-111 316275001466 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001467 HMMPfam hit to PF03144, Elongation factor Tu domain, score 9.6e-21 316275001468 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 5.5e-70 316275001469 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 3.2e-49 316275001470 elongation factor Tu; Reviewed; Region: PRK00049 316275001471 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 316275001472 G1 box; other site 316275001473 GEF interaction site [polypeptide binding]; other site 316275001474 GTP/Mg2+ binding site [chemical binding]; other site 316275001475 Switch I region; other site 316275001476 G2 box; other site 316275001477 G3 box; other site 316275001478 Switch II region; other site 316275001479 G4 box; other site 316275001480 G5 box; other site 316275001481 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 316275001482 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 316275001483 Antibiotic Binding Site [chemical binding]; other site 316275001484 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.3e-97 316275001485 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001486 PS00301 GTP-binding elongation factors signature. 316275001487 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.4e-24 316275001488 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 2.5e-60 316275001489 HMMPfam hit to PF04986, transposase, score 3e-24 316275001490 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275001491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275001492 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275001493 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275001494 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275001495 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275001496 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.8e-109, 55.781% id in 493 aa. CDS contains a frameshift after codon 73 316275001497 HMMPfam hit to PF03050, Transposase IS66 family,score 8.3e-57 316275001498 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 316275001499 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e, score 2e-60 316275001500 PS00361 Ribosomal protein S10 signature. 316275001501 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 316275001502 HMMPfam hit to PF00297, Ribosomal protein L3, score 5.2e-98 316275001503 PS00474 Ribosomal protein L3 signature. 316275001504 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 316275001505 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 2.6e-55 316275001506 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 316275001507 HMMPfam hit to PF00276, Ribosomal protein L23,score 9.3e-33 316275001508 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 316275001509 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 316275001510 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 316275001511 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 1.1e-45 316275001512 HMMPfam hit to PF03947, Ribosomal Proteins L2,C-terminal doma, score 1.4e-87 316275001513 PS00467 Ribosomal protein L2 signature. 316275001514 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 316275001515 HMMPfam hit to PF00203, Ribosomal protein S19,score 9.3e-52 316275001516 PS00323 Ribosomal protein S19 signature. 316275001517 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 316275001518 putative translocon binding site; other site 316275001519 protein-rRNA interface [nucleotide binding]; other site 316275001520 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e, score 5.1e-56 316275001521 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001522 PS00464 Ribosomal protein L22 signature. 316275001523 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 316275001524 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 316275001525 G-X-X-G motif; other site 316275001526 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 316275001527 HMMPfam hit to PF00417, Ribosomal protein S3,N-terminal domai, score 3.2e-27 316275001528 HMMPfam hit to PF07650, KH domain, score 2.1e-19 316275001529 HMMPfam hit to PF00189, Ribosomal protein S3,C-terminal domai, score 2.4e-52 316275001530 PS00548 Ribosomal protein S3 signature. 316275001531 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 316275001532 23S rRNA interface [nucleotide binding]; other site 316275001533 5S rRNA interface [nucleotide binding]; other site 316275001534 putative antibiotic binding site [chemical binding]; other site 316275001535 L25 interface [polypeptide binding]; other site 316275001536 L27 interface [polypeptide binding]; other site 316275001537 HMMPfam hit to PF00252, Ribosomal protein L16,score 5.1e-85 316275001538 PS00586 Ribosomal protein L16 signature 1. 316275001539 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 316275001540 trigger factor interaction site; other site 316275001541 23S rRNA interface [nucleotide binding]; other site 316275001542 HMMPfam hit to PF00831, Ribosomal L29 protein,score 8.4e-29 316275001543 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 316275001544 HMMPfam hit to PF00366, Ribosomal protein S17,score 1.7e-39 316275001545 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 316275001546 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e, score 2.1e-74 316275001547 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 316275001548 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 316275001549 RNA binding site [nucleotide binding]; other site 316275001550 HMMPfam hit to PF00467, KOW motif, score 1.2e-06 316275001551 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 316275001552 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 316275001553 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 316275001554 HMMPfam hit to PF00281, Ribosomal protein L5, score 2e-33 316275001555 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 3e-59 316275001556 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 316275001557 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e, score 4.9e-23 316275001558 PS00527 Ribosomal protein S14 signature. 316275001559 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 316275001560 HMMPfam hit to PF00410, Ribosomal protein S8, score 2.6e-65 316275001561 PS00053 Ribosomal protein S8 signature. 316275001562 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 316275001563 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316275001564 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 316275001565 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.4e-21 316275001566 HMMPfam hit to PF00347, Ribosomal protein L6, score 5.9e-31 316275001567 PS00525 Ribosomal protein L6 signature 1. 316275001568 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 316275001569 5S rRNA interface [nucleotide binding]; other site 316275001570 23S rRNA interface [nucleotide binding]; other site 316275001571 L5 interface [polypeptide binding]; other site 316275001572 HMMPfam hit to PF00861, Ribosomal L18p/L5e family,score 1.5e-50 316275001573 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 316275001574 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 316275001575 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 316275001576 HMMPfam hit to PF00333, Ribosomal protein S5,N-terminal domai, score 7.1e-38 316275001577 PS00585 Ribosomal protein S5 signature. 316275001578 HMMPfam hit to PF03719, Ribosomal protein S5,C-terminal domai, score 9.7e-37 316275001579 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 316275001580 23S rRNA binding site [nucleotide binding]; other site 316275001581 HMMPfam hit to PF00327, Ribosomal protein L30p/L7e,score 1.5e-19 316275001582 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 316275001583 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 6.7e-51 316275001584 HMMPfam hit to PF00256, Ribosomal protein L15,score 6.6e-09 316275001585 PS00475 Ribosomal protein L15 signature. 316275001586 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 316275001587 SecY translocase; Region: SecY; pfam00344 316275001589 HMMPfam hit to PF00344, eubacterial secY protein,score 7.4e-196 316275001590 PS00755 Protein secY signature 1. 316275001591 PS00756 Protein secY signature 2. 316275001592 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 316275001593 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 316275001594 30S ribosomal protein S13; Region: bact_S13; TIGR03631 316275001595 HMMPfam hit to PF00416, Ribosomal protein S13/S18,score 7.5e-59 316275001596 PS00061 Short-chain dehydrogenases/reductases family signature. 316275001597 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001598 PS00646 Ribosomal protein S13 signature. 316275001599 30S ribosomal protein S11; Validated; Region: PRK05309 316275001600 HMMPfam hit to PF00411, Ribosomal protein S11,score 1.3e-70 316275001601 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 316275001602 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 316275001603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275001604 RNA binding surface [nucleotide binding]; other site 316275001605 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 6.2e-36 316275001606 PS00632 Ribosomal protein S4 signature. 316275001607 HMMPfam hit to PF01479, S4 domain, score 5e-20 316275001608 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 316275001609 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 316275001610 alphaNTD homodimer interface [polypeptide binding]; other site 316275001611 alphaNTD - beta interaction site [polypeptide binding]; other site 316275001612 alphaNTD - beta' interaction site [polypeptide binding]; other site 316275001613 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 316275001614 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 8.2e-22 316275001615 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 8.4e-59 316275001616 HMMPfam hit to PF03118, Bacterial RNA polymerase,alpha chain C, score 9.8e-36 316275001617 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 316275001618 HMMPfam hit to PF01196, Ribosomal protein L17,score 1.4e-62 316275001619 PS01167 Ribosomal protein L17 signature. 316275001620 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 316275001621 AMP binding site [chemical binding]; other site 316275001622 metal binding site [ion binding]; metal-binding site 316275001623 active site 316275001624 HMMPfam hit to PF00316,Fructose-1-6-bisphosphatase, score 5.6e-197 316275001625 PS00124 Fructose-1-6-bisphosphatase active site. 316275001626 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 316275001627 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316275001628 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316275001629 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316275001630 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 2e-30 316275001631 HMMPfam hit to PF08245, Mur ligase middle domain,score 1e-18 316275001632 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 1.4e-08 316275001633 aromatic acid decarboxylase; Validated; Region: PRK05920 316275001634 Flavoprotein; Region: Flavoprotein; pfam02441 316275001635 HMMPfam hit to PF02441, Flavoprotein, score 1.3e-22 316275001636 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 316275001637 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 316275001638 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 0.00062 316275001639 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 316275001640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275001641 dimer interface [polypeptide binding]; other site 316275001642 putative PBP binding loops; other site 316275001643 ABC-ATPase subunit interface; other site 316275001644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275001645 dimer interface [polypeptide binding]; other site 316275001646 conserved gate region; other site 316275001647 putative PBP binding loops; other site 316275001648 ABC-ATPase subunit interface; other site 316275001650 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.002 316275001651 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0049 316275001652 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 316275001653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275001654 Walker A/P-loop; other site 316275001655 ATP binding site [chemical binding]; other site 316275001656 Q-loop/lid; other site 316275001657 ABC transporter signature motif; other site 316275001658 Walker B; other site 316275001659 D-loop; other site 316275001660 H-loop/switch region; other site 316275001661 HMMPfam hit to PF00005, ABC transporter score 1.6e-55 316275001662 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001663 PS00211 ABC transporters family signature. 316275001664 ATP-dependent helicase HepA; Validated; Region: PRK04914 316275001665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275001666 ATP binding site [chemical binding]; other site 316275001667 putative Mg++ binding site [ion binding]; other site 316275001668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275001669 nucleotide binding region [chemical binding]; other site 316275001670 ATP-binding site [chemical binding]; other site 316275001671 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 9.8e-06 316275001672 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 9.2e-48 316275001673 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 8.7e-16 316275001674 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001675 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316275001676 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316275001677 active site 316275001678 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.9e-44 316275001679 PS01129 Rlu family of pseudouridine synthase signature. 316275001680 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316275001681 Ligand Binding Site [chemical binding]; other site 316275001682 HMMPfam hit to PF00582, Universal stress protein family, score 2.4e-20 316275001683 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 316275001684 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 316275001685 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 316275001687 HMMPfam hit to PF06808, DctM-like transporters,score 5.2e-77 316275001688 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 316275001689 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 316275001690 Similar to Shewanella oneidensis issod7,transposase. UniProt:Q8CM19 (EMBL:AE014299) (440 aa) fasta scores: E()=8.1e-88, 48.409% id in 440 aa. CDS contains a frameshift after codon 230 316275001691 HMMPfam hit to PF01609, Transposase DDE domain,score 7.6e-28 316275001692 arginine repressor; Provisional; Region: PRK05066 316275001693 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 316275001694 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 316275001695 HMMPfam hit to PF02863, Arginine repressor,C-terminal domain, score 4.3e-21 316275001696 HMMPfam hit to PF01316, Arginine repressor, DNA binding domai, score 6e-26 316275001697 malate dehydrogenase; Provisional; Region: PRK05086 316275001698 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 316275001699 NAD binding site [chemical binding]; other site 316275001700 dimerization interface [polypeptide binding]; other site 316275001701 Substrate binding site [chemical binding]; other site 316275001702 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 3.3e-72 316275001703 PS00068 Malate dehydrogenase active site signature. 316275001704 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 9.8e-70 316275001705 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 316275001706 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316275001707 substrate binding pocket [chemical binding]; other site 316275001708 chain length determination region; other site 316275001709 substrate-Mg2+ binding site; other site 316275001710 catalytic residues [active] 316275001711 aspartate-rich region 1; other site 316275001712 active site lid residues [active] 316275001713 aspartate-rich region 2; other site 316275001714 HMMPfam hit to PF00348, Polyprenyl synthetase,score 4.6e-106 316275001715 PS00444 Polyprenyl synthetases signature 2. 316275001716 PS00723 Polyprenyl synthetases signature 1. 316275001717 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 316275001718 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 316275001719 HMMPfam hit to PF00829, Ribosomal prokaryotic L21 protein, score 1.8e-59 316275001720 PS01169 Ribosomal protein L21 signature. 316275001721 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 316275001722 HMMPfam hit to PF01016, Ribosomal L27 protein,score 1.2e-56 316275001723 PS00831 Ribosomal protein L27 signature. 316275001724 GTPase CgtA; Reviewed; Region: obgE; PRK12298 316275001725 GTP1/OBG; Region: GTP1_OBG; pfam01018 316275001726 Obg GTPase; Region: Obg; cd01898 316275001727 G1 box; other site 316275001728 GTP/Mg2+ binding site [chemical binding]; other site 316275001729 Switch I region; other site 316275001730 G2 box; other site 316275001731 G3 box; other site 316275001732 Switch II region; other site 316275001733 G4 box; other site 316275001734 G5 box; other site 316275001735 HMMPfam hit to PF01018, GTP1/OBG, score 2.1e-82 316275001736 HMMPfam hit to PF01926, GTPase of unknown function,score 1.9e-37 316275001737 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001738 PS00905 GTP1/OBG family signature. 316275001739 Uncharacterized conserved protein [Function unknown]; Region: COG2966 316275001740 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 316275001741 HMMPfam hit to PF06738, Protein of unknown function (DUF1212), score 7.6e-63 316275001743 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 316275001745 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 316275001746 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 316275001747 folate binding site [chemical binding]; other site 316275001748 NADP+ binding site [chemical binding]; other site 316275001749 HMMPfam hit to PF00186, Dihydrofolate reductase,score 4.8e-52 316275001750 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 316275001751 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 316275001752 active site 316275001753 metal binding site [ion binding]; metal-binding site 316275001754 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.5e-15 316275001755 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 316275001756 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 316275001757 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 1.1e-96 316275001758 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 316275001759 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 316275001760 HMMPfam hit to PF04166, Pyridoxal phosphate biosynthetic protein Pdx, score 1.6e-161 316275001761 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 316275001762 SurA N-terminal domain; Region: SurA_N; pfam09312 316275001763 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 316275001764 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 316275001765 HMMPfam hit to PF00639, PPIC-type PPIASE domain,score 8.1e-27 316275001766 HMMPfam hit to PF00639, PPIC-type PPIASE domain,score 9.7e-18 316275001767 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 316275001768 OstA-like protein; Region: OstA; pfam03968 316275001769 Organic solvent tolerance protein; Region: OstA_C; pfam04453 316275001770 HMMPfam hit to PF04453, Organic solvent tolerance protein, score 1.7e-135 316275001771 HMMPfam hit to PF03968, OstA-like protein, score 2.4e-44 316275001772 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 316275001773 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 316275001774 putative metal binding site [ion binding]; other site 316275001775 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316275001776 HSP70 interaction site [polypeptide binding]; other site 316275001778 HMMPfam hit to PF00226, DnaJ domain, score 1.3e-09 316275001779 Protein of unknown function, DUF547; Region: DUF547; pfam04784 316275001780 HMMPfam hit to PF04784, Protein of unknown function, DUF547, score 4.1e-38 316275001781 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 316275001782 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 316275001783 substrate binding site [chemical binding]; other site 316275001784 HMMPfam hit to PF00694, Aconitase C-terminal domain, score 3.8e-62 316275001785 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 316275001786 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 316275001787 substrate binding site [chemical binding]; other site 316275001788 ligand binding site [chemical binding]; other site 316275001789 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 3.4e-266 316275001790 PS01244 Aconitase family signature 2. 316275001791 PS00450 Aconitase family signature 1. 316275001792 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 316275001793 tartrate dehydrogenase; Region: TTC; TIGR02089 316275001794 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 2.2e-210 316275001795 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 316275001796 2-isopropylmalate synthase; Validated; Region: PRK00915 316275001797 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 316275001798 active site 316275001799 catalytic residues [active] 316275001800 metal binding site [ion binding]; metal-binding site 316275001801 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 316275001802 HMMPfam hit to PF08502, LeuA allosteric (dimerisation) domain, score 8.3e-52 316275001803 HMMPfam hit to PF00682, HMGL-like, score 3.4e-137 316275001804 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 316275001805 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 316275001806 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E855 (214 aa) fasta scores: E()=1.2e-60, 80.193% id in 207 aa. CDS contains a nonsense mutation (CAA to TAA) after codon 137. The sequence has been checked and is believed to be correct 316275001807 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 4.5e-12 316275001808 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275001809 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275001811 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316275001812 Protein export membrane protein; Region: SecD_SecF; cl14618 316275001813 Protein export membrane protein; Region: SecD_SecF; cl14618 316275001814 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family,score 3.6e-72 316275001816 Protein of unknown function, DUF481; Region: DUF481; pfam04338 316275001817 HMMPfam hit to PF04338, Protein of unknown function, DUF481, score 3.4e-73 316275001818 replicative DNA helicase; Provisional; Region: PRK08840 316275001819 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 316275001820 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 316275001821 Walker A motif; other site 316275001822 ATP binding site [chemical binding]; other site 316275001823 Walker B motif; other site 316275001824 DNA binding loops [nucleotide binding] 316275001825 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 3.8e-54 316275001826 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 2e-141 316275001827 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001828 Predicted helix-turn-helix motif with score 1557.000, SD 4.49 at aa 360-381, sequence RSLKALAKELNVPVVALSQLNR 316275001829 alanine racemase; Reviewed; Region: alr; PRK00053 316275001830 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 316275001831 active site 316275001832 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316275001833 substrate binding site [chemical binding]; other site 316275001834 catalytic residues [active] 316275001835 dimer interface [polypeptide binding]; other site 316275001836 HMMPfam hit to PF01168, Alanine racemase,N-terminal domain, score 1.7e-93 316275001837 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 316275001838 HMMPfam hit to PF00842, Alanine racemase,C-terminal domain, score 7.1e-72 316275001839 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 316275001840 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 316275001841 active site 316275001842 dimer interface [polypeptide binding]; other site 316275001843 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 316275001844 dimer interface [polypeptide binding]; other site 316275001845 active site 316275001846 HMMPfam hit to PF00342, Phosphoglucose isomerase,score 0 316275001847 PS00765 Phosphoglucose isomerase signature 1. 316275001848 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 316275001849 PS00174 Phosphoglucose isomerase signature 2. 316275001850 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 316275001851 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 316275001852 HMMPfam hit to PF04509, CheC-like family, score 6.6e-08 316275001853 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316275001854 metal binding site 2 [ion binding]; metal-binding site 316275001855 putative DNA binding helix; other site 316275001856 metal binding site 1 [ion binding]; metal-binding site 316275001857 dimer interface [polypeptide binding]; other site 316275001858 structural Zn2+ binding site [ion binding]; other site 316275001859 HMMPfam hit to PF01475, Ferric uptake regulator family, score 1.2e-05 316275001860 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 316275001861 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 316275001862 ADP-ribose binding site [chemical binding]; other site 316275001863 HMMPfam hit to PF01661, Appr-1-p processing enzyme family, score 1.5e-22 316275001864 Homeodomain-like domain; Region: HTH_23; cl17451 316275001865 Winged helix-turn helix; Region: HTH_29; pfam13551 316275001866 Homeodomain-like domain; Region: HTH_32; pfam13565 316275001867 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275001868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275001869 No significant database matches. CDS is probably truncated by the insertion of the downstream IS element and subsequent recombination events 316275001870 AAA domain; Region: AAA_25; pfam13481 316275001871 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 316275001872 Walker A motif; other site 316275001873 ATP binding site [chemical binding]; other site 316275001874 Walker B motif; other site 316275001875 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275001876 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 316275001877 active site 316275001878 DNA binding site [nucleotide binding] 316275001879 Int/Topo IB signature motif; other site 316275001880 HMMPfam hit to PF00589, Phage integrase family,score 2.5e-27 316275001881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275001882 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 316275001883 active site 316275001884 Int/Topo IB signature motif; other site 316275001885 DNA binding site [nucleotide binding] 316275001886 HMMPfam hit to PF00589, Phage integrase family,score 2.7e-14 316275001887 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 316275001888 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 316275001889 FMN binding site [chemical binding]; other site 316275001890 active site 316275001891 catalytic residues [active] 316275001892 substrate binding site [chemical binding]; other site 316275001893 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 2.3e-131 316275001894 PS01136 Uncharacterized protein family UPF0034 signature. 316275001895 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 316275001896 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 316275001897 Flavodoxin; Region: Flavodoxin_1; pfam00258 316275001898 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 316275001899 FAD binding pocket [chemical binding]; other site 316275001900 FAD binding motif [chemical binding]; other site 316275001901 catalytic residues [active] 316275001902 NAD binding pocket [chemical binding]; other site 316275001903 phosphate binding motif [ion binding]; other site 316275001904 beta-alpha-beta structure motif; other site 316275001905 HMMPfam hit to PF00258, Flavodoxin, score 1.2e-34 316275001906 HMMPfam hit to PF00667, FAD binding domain, score 1e-43 316275001907 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 7.1e-31 316275001908 sulfite reductase subunit beta; Provisional; Region: PRK13504 316275001909 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316275001910 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316275001911 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 1.7e-20 316275001912 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 1.7e-56 316275001913 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 8.2e-18 316275001914 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 316275001915 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 316275001916 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 316275001917 Active Sites [active] 316275001918 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 1.8e-71 316275001919 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 316275001921 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 316275001922 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 316275001923 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316275001924 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 3.5e-43 316275001925 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 316275001926 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 316275001927 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 316275001928 HMMPfam hit to PF08525, Opacity-associated protein A N-terminal moti, score 1e-08 316275001929 HMMPfam hit to PF04225, Opacity-associated protein A LysM-like domai, score 9.5e-50 316275001930 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275001932 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2e-16 316275001933 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316275001934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275001935 Coenzyme A binding pocket [chemical binding]; other site 316275001936 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.3e-11 316275001937 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316275001938 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 316275001939 ligand binding site [chemical binding]; other site 316275001940 flexible hinge region; other site 316275001941 Predicted helix-turn-helix motif with score 1314.000, SD 3.66 at aa 162-183, sequence LTDYQIAAYLGITHISLSRIKG 316275001942 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 1.3e-10 316275001943 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 316275001944 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316275001945 putative acyl-acceptor binding pocket; other site 316275001946 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 316275001947 HMMPfam hit to PF01553, Acyltransferase, score 3.7e-06 316275001949 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 316275001950 HMMPfam hit to PF04945, YHS domain, score 9.4e-05 316275001951 NRDE protein; Region: NRDE; cl01315 316275001952 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316275001953 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316275001954 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316275001957 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 316275001958 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 316275001959 active site 316275001960 metal binding site [ion binding]; metal-binding site 316275001961 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316275001962 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 3.2e-58 316275001963 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 8.7e-15 316275001964 PS00786 5'-nucleotidase signature 2. 316275001965 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275001966 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 316275001967 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 316275001968 Active Sites [active] 316275001969 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 2.6e-135 316275001970 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 316275001971 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 316275001972 CysD dimerization site [polypeptide binding]; other site 316275001973 G1 box; other site 316275001974 putative GEF interaction site [polypeptide binding]; other site 316275001975 GTP/Mg2+ binding site [chemical binding]; other site 316275001976 Switch I region; other site 316275001977 G2 box; other site 316275001978 G3 box; other site 316275001979 Switch II region; other site 316275001980 G4 box; other site 316275001981 G5 box; other site 316275001982 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 316275001983 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 316275001984 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.2e-69 316275001985 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001986 PS00301 GTP-binding elongation factors signature. 316275001987 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.9e-10 316275001988 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 316275001989 TrkA-C domain; Region: TrkA_C; pfam02080 316275001990 TrkA-C domain; Region: TrkA_C; pfam02080 316275001991 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 316275001992 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 316275001994 HMMPfam hit to PF03600, Citrate transporter score 9.5e-05 316275001995 HMMPfam hit to PF06808, DctM-like transporters,score 7.5e-05 316275001996 HMMPfam hit to PF02080, TrkA-C domain, score 1.3e-11 316275001997 PS00017 ATP/GTP-binding site motif A (P-loop). 316275001998 HMMPfam hit to PF02080, TrkA-C domain, score 1.1e-10 316275001999 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 316275002000 ligand-binding site [chemical binding]; other site 316275002001 HMMPfam hit to PF01583, Adenylylsulphate kinase,score 1.2e-108 316275002002 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002003 TIGR03899 family protein; Region: TIGR03899 316275002004 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 316275002005 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316275002006 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316275002007 FtsX-like permease family; Region: FtsX; pfam02687 316275002008 HMMPfam hit to PF02687, Predicted permease, score 6.9e-27 316275002010 PS00358 Ribosomal protein L5 signature. 316275002011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316275002012 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316275002013 Walker A/P-loop; other site 316275002014 ATP binding site [chemical binding]; other site 316275002015 Q-loop/lid; other site 316275002016 ABC transporter signature motif; other site 316275002017 Walker B; other site 316275002018 D-loop; other site 316275002019 H-loop/switch region; other site 316275002020 HMMPfam hit to PF00005, ABC transporter score 1.9e-50 316275002021 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002022 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 316275002023 Protein of unknown function (DUF2607); Region: DUF2607; pfam10795 316275002025 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 316275002026 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 316275002027 HMMPfam hit to PF06526, Protein of unknown function (DUF1107), score 3.9e-30 316275002028 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 316275002029 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 1.9e-96 316275002030 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 316275002031 Surface antigen; Region: Bac_surface_Ag; pfam01103 316275002032 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 5.6e-05 316275002033 HMMPfam hit to PF01103, Surface antigen, score 5.4e-76 316275002034 PS00213 Lipocalin signature. 316275002035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 316275002036 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 316275002037 Family of unknown function (DUF490); Region: DUF490; pfam04357 316275002039 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002040 HMMPfam hit to PF04357, Family of unknown function (DUF490), score 5.9e-43 316275002041 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275002042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275002043 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275002044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275002045 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275002046 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275002047 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275002048 Similar to Shewanella oneidensis issod7,transposase. UniProt:Q8CM19 (EMBL:AE014299) (440 aa) fasta scores: E()=5e-36, 44.241% id in 382 aa. CDS contains frameshifts and is truncated by the insertion of the upstream IS element and subsequent recombination events 316275002049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 316275002050 Transposase; Region: HTH_Tnp_1; pfam01527 316275002051 HMMPfam hit to PF01527, Transposase, score 2.7e-16 316275002052 Predicted helix-turn-helix motif with score 1720.000, SD 5.05 at aa 26-47, sequence HSVAEVAKAMNVGKSTMDKWVR 316275002053 putative transposase OrfB; Reviewed; Region: PHA02517 316275002054 HTH-like domain; Region: HTH_21; pfam13276 316275002055 Integrase core domain; Region: rve; pfam00665 316275002056 Integrase core domain; Region: rve_3; cl15866 316275002057 HMMPfam hit to PF00665, Integrase core domain,score 9.2e-44 316275002058 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 316275002059 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316275002060 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 1.5e-51 316275002062 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 316275002063 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 316275002064 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 316275002065 substrate binding pocket [chemical binding]; other site 316275002066 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 316275002067 B12 binding site [chemical binding]; other site 316275002068 cobalt ligand [ion binding]; other site 316275002069 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 316275002070 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 3.3e-151 316275002071 HMMPfam hit to PF00809, Pterin binding enzyme,score 1.5e-70 316275002072 HMMPfam hit to PF02607, B12 binding domain, score 1.2e-43 316275002073 HMMPfam hit to PF02310, B12 binding domain, score 5e-28 316275002074 HMMPfam hit to PF02965, Vitamin B12 dependent methionine synth, score 9.4e-72 316275002075 Similar to Escherichia coli Lysine-sensitive aspartokinase 3 LysC UniProt:P08660 (449 aa) fasta scores: E()=1.7e-10, 57.407% id in 54 aa. CDS is disrupted by the insertion of an IS element after codon 336 316275002076 HMMPfam hit to PF01842, ACT domain, score 0.00011 316275002077 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275002078 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275002079 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275002080 HMMPfam hit to PF00696, Amino acid kinase family,score 1.4e-27 316275002081 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 316275002082 homodimer interface [polypeptide binding]; other site 316275002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275002084 catalytic residue [active] 316275002085 HMMPfam hit to PF00266, Aminotransferase class-V,score 2.8e-13 316275002086 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 316275002087 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 316275002088 O-Antigen ligase; Region: Wzy_C; pfam04932 316275002089 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 316275002091 HMMPfam hit to PF04932, O-Antigen Polymerase, score 6.5e-16 316275002092 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 316275002093 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316275002094 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 316275002095 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 316275002096 HMMPfam hit to PF00005, ABC transporter score 4.2e-40 316275002097 PS00211 ABC transporters family signature. 316275002098 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002099 HMMPfam hit to PF00005, ABC transporter score 4.6e-08 316275002100 PS00211 ABC transporters family signature. 316275002101 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002102 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 316275002103 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 316275002104 active site 316275002105 tetramer interface; other site 316275002106 HMMPfam hit to PF00483, Nucleotidyl transferase,score 3.6e-21 316275002108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275002109 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316275002110 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.1e-25 316275002111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275002112 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316275002113 HMMPfam hit to PF00534, Glycosyl transferases group, score 8e-33 316275002114 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316275002115 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316275002116 active site 316275002118 HMMPfam hit to PF00535, Glycosyl transferase family, score 8e-17 316275002120 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 316275002121 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316275002124 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275002125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275002126 Homeodomain-like domain; Region: HTH_23; cl17451 316275002127 Winged helix-turn helix; Region: HTH_29; pfam13551 316275002128 Homeodomain-like domain; Region: HTH_32; pfam13565 316275002129 HMMPfam hit to PF02706, Chain length determinant protein, score 2.2e-17 316275002131 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 316275002132 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 316275002133 SLBB domain; Region: SLBB; pfam10531 316275002134 HMMPfam hit to PF02563, Polysaccharide biosynthesis/export protei, score 1.6e-33 316275002135 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 316275002136 Similar to Escherichia coli colanic biosynthesis UDP-glucose lipid carrier transferase UniProt:P71241 (464 aa), E()=3.5e-63 id 48.387%; ungapped id 51.429%; 372 aa overlap. Contains a framshift after codon 37. The sequence has been checked and is believed to be correct. 316275002137 HMMPfam hit to PF02397, Bacterial sugar transferase, score 1.1e-37 316275002139 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 316275002140 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316275002141 dimer interface [polypeptide binding]; other site 316275002142 ssDNA binding site [nucleotide binding]; other site 316275002143 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316275002144 putative single-stranded DNA-binding protein; Region: PHA01740 316275002145 HMMPfam hit to PF00436, Single-strand binding protein family, score 3.6e-37 316275002146 PS00735 Single-strand binding protein family signature 1. 316275002147 PS00736 Single-strand binding protein family signature 2. 316275002149 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275002150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275002151 Homeodomain-like domain; Region: HTH_23; cl17451 316275002152 Winged helix-turn helix; Region: HTH_29; pfam13551 316275002153 Homeodomain-like domain; Region: HTH_32; pfam13565 316275002154 regulatory protein CsrD; Provisional; Region: PRK11059 316275002155 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275002156 metal binding site [ion binding]; metal-binding site 316275002157 active site 316275002158 I-site; other site 316275002159 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275002161 HMMPfam hit to PF00990, GGDEF domain, score 2.8e-10 316275002162 HMMPfam hit to PF00563, EAL domain, score 1.2e-41 316275002163 Pilus assembly protein, PilO; Region: PilO; cl01234 316275002165 Secretin N-terminal domain; Region: Secretin_N_2; pfam07655 316275002166 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 316275002167 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 316275002168 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275002169 HMMPfam hit to PF07660, Secretin and TonB N terminus short domai, score 2.6e-08 316275002170 HMMPfam hit to PF07655, Secretin N-terminal domain,score 6.2e-26 316275002171 HMMPfam hit to PF00263, Bacterial type II and III secretion syst, score 6.2e-67 316275002172 PS00875 Bacterial type II secretion system protein D signature. 316275002173 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 316275002174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275002175 Walker A motif; other site 316275002176 ATP binding site [chemical binding]; other site 316275002177 Walker B motif; other site 316275002178 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002179 Tetratricopeptide repeat; Region: TPR_16; pfam13432 316275002180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275002181 binding surface 316275002182 TPR motif; other site 316275002183 Similar to Vibrio cholerae Mannose-sensitive hemagglutinin E MshE (fragment) UniProt:Q56676 (535 aa) fasta scores: E()=5.8e-27, 73.874% id in 111 aa. Contains a nonsense mutation (GAA to TAA) after codon 114. The sequence has been checked and is believed to be correct 316275002184 HMMPfam hit to PF05157, GSPII_E N-terminal domain,score 1.9e-23 316275002185 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 3.7e-109 316275002186 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002187 PS00662 Bacterial type II secretion system protein E signature. 316275002188 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 316275002189 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316275002190 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316275002191 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 5.1e-25 316275002193 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.8e-20 316275002195 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 2e-07 316275002197 PS00409 Prokaryotic N-terminal methylation site. 316275002198 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 5.9e-08 316275002200 PS00409 Prokaryotic N-terminal methylation site. 316275002201 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 5.9e-08 316275002203 PS00409 Prokaryotic N-terminal methylation site. 316275002205 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.4e-06 316275002206 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 316275002207 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 316275002208 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 0.004 316275002209 PS00409 Prokaryotic N-terminal methylation site. 316275002211 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 316275002212 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 8.7e-07 316275002213 PS00409 Prokaryotic N-terminal methylation site. 316275002215 PS00044 Bacterial regulatory proteins, lysR family signature. 316275002217 PS00881 Protein splicing signature. 316275002218 rod shape-determining protein MreB; Provisional; Region: PRK13927 316275002219 MreB and similar proteins; Region: MreB_like; cd10225 316275002220 nucleotide binding site [chemical binding]; other site 316275002221 Mg binding site [ion binding]; other site 316275002222 putative protofilament interaction site [polypeptide binding]; other site 316275002223 RodZ interaction site [polypeptide binding]; other site 316275002224 HMMPfam hit to PF06723, MreB/Mbl protein, score 2e-235 316275002225 rod shape-determining protein MreC; Provisional; Region: PRK13922 316275002226 rod shape-determining protein MreC; Region: MreC; pfam04085 316275002227 HMMPfam hit to PF04085, rod shape-determining protein MreC, score 1.4e-37 316275002228 rod shape-determining protein MreD; Provisional; Region: PRK11060 316275002229 HMMPfam hit to PF04093, rod shape-determining protein MreD, score 2.4e-34 316275002231 PS00041 Bacterial regulatory proteins, araC family signature. 316275002232 Maf-like protein; Region: Maf; pfam02545 316275002233 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 316275002234 active site 316275002235 dimer interface [polypeptide binding]; other site 316275002236 HMMPfam hit to PF02545, Maf-like protein, score 3.7e-66 316275002237 ribonuclease G; Provisional; Region: PRK11712 316275002238 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 316275002239 homodimer interface [polypeptide binding]; other site 316275002240 oligonucleotide binding site [chemical binding]; other site 316275002241 HMMPfam hit to PF00575, S1 RNA binding domain,score 2.9e-15 316275002242 TIGR02099 family protein; Region: TIGR02099 316275002243 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 316275002245 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 316275002246 putative active site [active] 316275002247 catalytic triad [active] 316275002248 dimer interface [polypeptide binding]; other site 316275002249 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase,score 2.2e-27 316275002250 PS01227 Uncharacterized protein family UPF0012 signature. 316275002251 protease TldD; Provisional; Region: tldD; PRK10735 316275002252 HMMPfam hit to PF01523, modulator of DNA gyrase, score 9.6e-89 316275002253 hypothetical protein; Provisional; Region: PRK05255 316275002254 HMMPfam hit to PF04751, Protein of unknown function (DUF615), score 1.7e-96 316275002255 peptidase PmbA; Provisional; Region: PRK11040 316275002256 HMMPfam hit to PF01523, modulator of DNA gyrase, score 3.8e-64 316275002257 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 316275002258 MgtE intracellular N domain; Region: MgtE_N; smart00924 316275002259 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 316275002260 Divalent cation transporter; Region: MgtE; pfam01769 316275002262 HMMPfam hit to PF01769, Divalent cation transporter score 1.5e-14 316275002263 HMMPfam hit to PF00571, CBS domain pair, score 2.6e-11 316275002264 HMMPfam hit to PF03448, MgtE intracellular domain,score 4.7e-44 316275002265 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316275002266 regulatory protein interface [polypeptide binding]; other site 316275002267 active site 316275002268 regulatory phosphorylation site [posttranslational modification]; other site 316275002269 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 1.4e-23 316275002270 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 316275002271 HMMPfam hit to PF03668, P-loop ATPase protein family, score 3.3e-153 316275002272 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002273 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275002274 active site 316275002275 phosphorylation site [posttranslational modification] 316275002276 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 1.4e-37 316275002277 PS00372 PTS EIIA domains phosphorylation site signature 2. 316275002278 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 316275002279 30S subunit binding site; other site 316275002280 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 1.2e-45 316275002281 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 316275002282 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 316275002283 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 316275002284 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 316275002285 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 3.2e-112 316275002286 PS00718 Sigma-54 factors family signature 2. 316275002287 Predicted helix-turn-helix motif with score 1190.000, SD 3.24 at aa 377-398, sequence MVLNDIALDVEMHESTISRVTT 316275002288 PS00717 Sigma-54 factors family signature 1. 316275002289 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 1.4e-103 316275002290 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 1.4e-20 316275002291 PS00041 Bacterial regulatory proteins, araC family signature. 316275002292 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 316275002293 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 316275002294 Walker A/P-loop; other site 316275002295 ATP binding site [chemical binding]; other site 316275002296 Q-loop/lid; other site 316275002297 ABC transporter signature motif; other site 316275002298 Walker B; other site 316275002299 D-loop; other site 316275002300 H-loop/switch region; other site 316275002301 HMMPfam hit to PF00005, ABC transporter score 1.6e-59 316275002302 PS00211 ABC transporters family signature. 316275002303 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002304 OstA-like protein; Region: OstA; cl00844 316275002305 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 316275002306 HMMPfam hit to PF03968, OstA-like protein, score 6.8e-60 316275002307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 316275002308 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 316275002309 HMMPfam hit to PF06835, Protein of unknown function (DUF1239), score 1.3e-56 316275002311 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 316275002312 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 316275002313 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 316275002314 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 316275002315 putative active site [active] 316275002316 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 316275002317 HMMPfam hit to PF00571, CBS domain pair, score 1.4e-22 316275002318 HMMPfam hit to PF01380, SIS domain, score 9.5e-36 316275002319 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 316275002320 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 316275002321 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 316275002323 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 5.8e-42 316275002324 HMMPfam hit to PF01699, Sodium/calcium exchanger protein, score 2.9e-36 316275002325 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002326 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 316275002327 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 316275002328 Walker A/P-loop; other site 316275002329 ATP binding site [chemical binding]; other site 316275002330 Q-loop/lid; other site 316275002331 ABC transporter signature motif; other site 316275002332 Walker B; other site 316275002333 D-loop; other site 316275002334 H-loop/switch region; other site 316275002335 HMMPfam hit to PF00005, ABC transporter score 5.2e-49 316275002336 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002337 PS00211 ABC transporters family signature. 316275002338 Permease; Region: Permease; cl00510 316275002339 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 316275002340 HMMPfam hit to PF02405, Domain of unknown function DUF140, score 1.6e-117 316275002342 mce related protein; Region: MCE; pfam02470 316275002343 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 316275002345 HMMPfam hit to PF02470, mce related protein, score 4.5e-18 316275002346 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 316275002347 HMMPfam hit to PF05494, Toluene tolerance, Ttg2,score 1.7e-63 316275002348 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316275002349 anti sigma factor interaction site; other site 316275002350 regulatory phosphorylation site [posttranslational modification]; other site 316275002351 HMMPfam hit to PF01740, STAS domain, score 0.0017 316275002352 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 316275002353 HMMPfam hit to PF01722, BolA-like protein, score 4.3e-33 316275002354 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 316275002355 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 316275002356 hinge; other site 316275002357 active site 316275002358 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 4.6e-167 316275002359 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 316275002360 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316275002361 putative acyl-acceptor binding pocket; other site 316275002363 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275002364 HMMPfam hit to PF01553, Acyltransferase, score 3.5e-47 316275002365 HMMPfam hit to PF00293, NUDIX domain, score 6.8e-16 316275002366 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=2.7e-115, 55.781% id in 493 aa. CDS contains several frameshifts and translational stop codons 316275002367 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275002368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275002369 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275002370 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275002371 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 316275002372 homotrimer interaction site [polypeptide binding]; other site 316275002373 putative active site [active] 316275002374 HMMPfam hit to PF01042, Endoribonuclease L-PSP,score 4.4e-63 316275002375 PS01094 Uncharacterized protein family UPF0076 signature. 316275002376 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 316275002377 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 316275002378 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 316275002379 HMMPfam hit to PF02748, Aspartate carbamoyltransferase regulatory ch, score 3.4e-24 316275002380 HMMPfam hit to PF01948, Aspartate carbamoyltransferase regulatory ch, score 1e-50 316275002381 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 316275002382 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316275002383 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316275002384 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 3.3e-54 316275002385 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 1.5e-60 316275002386 PS00097 Aspartate and ornithine carbamoyltransferases signature. 316275002387 ornithine carbamoyltransferase; Validated; Region: PRK02102 316275002388 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 316275002389 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 316275002390 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, As, score 1.5e-87 316275002391 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, ca, score 4.5e-80 316275002392 PS00097 Aspartate and ornithine carbamoyltransferases signature. 316275002393 arginine deiminase; Provisional; Region: PRK01388 316275002394 HMMPfam hit to PF02274, Amidinotransferase, score 9.7e-174 316275002395 RNase E inhibitor protein; Provisional; Region: PRK11191 316275002396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 316275002397 HMMPfam hit to PF06877, Protein of unknown function (DUF1260), score 3.2e-46 316275002398 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 316275002399 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 316275002400 HIGH motif; other site 316275002401 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 316275002402 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 316275002403 active site 316275002404 KMSKS motif; other site 316275002405 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 316275002406 tRNA binding surface [nucleotide binding]; other site 316275002407 anticodon binding site; other site 316275002408 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 316275002409 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002410 HMMPfam hit to PF08264, Anticodon-binding domain,score 1.9e-62 316275002411 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 316275002412 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275002413 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 316275002414 HMMPfam hit to PF04364, DNA polymerase III chi subunit, HolC, score 1.5e-56 316275002415 multifunctional aminopeptidase A; Provisional; Region: PRK00913 316275002416 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 316275002417 interface (dimer of trimers) [polypeptide binding]; other site 316275002418 Substrate-binding/catalytic site; other site 316275002419 Zn-binding sites [ion binding]; other site 316275002420 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 1.1e-186 316275002421 PS00631 Cytosol aminopeptidase signature. 316275002422 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 3.3e-41 316275002423 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 316275002424 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 316275002425 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 2.9e-92 316275002427 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 316275002428 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 316275002429 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 2.2e-96 316275002431 RDD family; Region: RDD; pfam06271 316275002432 HMMPfam hit to PF06271, RDD family, score 4.3e-29 316275002434 Protein of unknown function (DUF2999); Region: DUF2999; pfam11212 316275002435 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 316275002436 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 1.3e-44 316275002438 PS01069 Prokaryotic diacylglycerol kinase signature. 316275002439 murein transglycosylase C; Provisional; Region: mltC; PRK11671 316275002440 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 316275002441 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275002442 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275002443 catalytic residue [active] 316275002444 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 4.5e-36 316275002445 PS00922 Prokaryotic transglycosylases signature. 316275002446 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275002447 oxidative damage protection protein; Provisional; Region: PRK05408 316275002448 HMMPfam hit to PF04362, Bacterial Fe(2+) trafficking, score 4.8e-61 316275002449 adenine DNA glycosylase; Provisional; Region: PRK10880 316275002450 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316275002451 minor groove reading motif; other site 316275002452 helix-hairpin-helix signature motif; other site 316275002453 substrate binding pocket [chemical binding]; other site 316275002454 active site 316275002455 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 316275002456 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 316275002457 DNA binding and oxoG recognition site [nucleotide binding] 316275002458 PS00764 Endonuclease III iron-sulfur binding region signature. 316275002459 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 4.1e-19 316275002460 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 0.0001 316275002461 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 316275002462 HMMPfam hit to PF02390, methyltransferase,score 3.6e-88 316275002463 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 316275002464 glutaminase; Provisional; Region: PRK00971 316275002465 HMMPfam hit to PF04960, Glutaminase, score 3.1e-182 316275002466 HemN family oxidoreductase; Provisional; Region: PRK05660 316275002467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275002468 FeS/SAM binding site; other site 316275002469 HemN C-terminal domain; Region: HemN_C; pfam06969 316275002470 HMMPfam hit to PF06969, HemN C-terminal region,score 3.3e-22 316275002471 HMMPfam hit to PF04055, Radical SAM superfamily,score 6e-28 316275002472 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 316275002473 active site 316275002474 dimerization interface [polypeptide binding]; other site 316275002475 HMMPfam hit to PF01725, Ham1 family, score 1.5e-97 316275002476 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 316275002477 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 316275002478 HMMPfam hit to PF02594, Uncharacterised ACR, YggU family COG1872, score 2.9e-34 316275002479 YGGT family; Region: YGGT; pfam02325 316275002480 YGGT family; Region: YGGT; pfam02325 316275002482 HMMPfam hit to PF02325, YGGT family, score 1.1e-28 316275002483 HMMPfam hit to PF02325, YGGT family, score 4.5e-23 316275002484 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 316275002485 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 316275002486 HMMPfam hit to PF03807, NADP oxidoreductase coenzyme F420-depe, score 2.4e-77 316275002487 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 316275002488 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 0.00084 316275002489 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 316275002490 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316275002491 catalytic residue [active] 316275002492 HMMPfam hit to PF01168, Alanine racemase,N-terminal domain, score 1.3e-36 316275002493 PS01211 Uncharacterized protein family UPF0001 signature. 316275002494 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 316275002495 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 316275002496 Walker A motif; other site 316275002497 ATP binding site [chemical binding]; other site 316275002498 Walker B motif; other site 316275002499 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 1.6e-26 316275002500 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002501 PS00662 Bacterial type II secretion system protein E signature. 316275002502 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 316275002503 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 316275002504 Walker A motif; other site 316275002505 ATP binding site [chemical binding]; other site 316275002506 Walker B motif; other site 316275002507 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 6.8e-17 316275002508 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002509 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 316275002510 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 3.5e-53 316275002511 hypothetical protein; Validated; Region: PRK00228 316275002512 HMMPfam hit to PF02622, Uncharacterized ACR,COG1678, score 3e-89 316275002513 glutathione synthetase; Provisional; Region: PRK05246 316275002514 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 316275002515 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 316275002516 HMMPfam hit to PF08443, RimK-like ATP-grasp domain,score 2.6e-05 316275002517 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-gra, score 2.1e-129 316275002518 HMMPfam hit to PF02951, Prokaryotic glutathione synthetase, N-termi, score 5.7e-61 316275002519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 316275002520 RNA methyltransferase, RsmE family; Region: TIGR00046 316275002521 HMMPfam hit to PF04452, Protein of unknown function (DUF558), score 4.1e-105 316275002522 DNA-specific endonuclease I; Provisional; Region: PRK15137 316275002523 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 316275002524 HMMPfam hit to PF04231, Endonuclease I, score 5.7e-127 316275002525 hypothetical protein; Provisional; Region: PRK04860 316275002526 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 316275002527 HMMPfam hit to PF03926, metallopeptidase (SprT family), score 3.3e-70 316275002528 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275002529 S-adenosylmethionine synthetase; Validated; Region: PRK05250 316275002530 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 316275002531 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 316275002532 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 316275002533 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, C-te, score 8.9e-88 316275002534 PS00377 S-adenosylmethionine synthetase signature 2. 316275002535 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, cent, score 2.1e-79 316275002536 PS00376 S-adenosylmethionine synthetase signature 1. 316275002537 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, N-te, score 3.3e-62 316275002538 transketolase; Reviewed; Region: PRK12753 316275002539 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 316275002540 TPP-binding site [chemical binding]; other site 316275002541 dimer interface [polypeptide binding]; other site 316275002542 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316275002543 PYR/PP interface [polypeptide binding]; other site 316275002544 dimer interface [polypeptide binding]; other site 316275002545 TPP binding site [chemical binding]; other site 316275002546 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316275002547 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 3.6e-238 316275002548 PS00801 Transketolase signature 1. 316275002549 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 3.2e-65 316275002551 PS00802 Transketolase signature 2. 316275002552 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 6.7e-15 316275002553 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 316275002554 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 316275002555 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316275002556 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 1.2e-74 316275002557 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 1.1e-72 316275002558 HMMPfam hit to PF00162, Phosphoglycerate kinase,score 4.8e-131 316275002559 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 316275002560 Phosphoglycerate kinase; Region: PGK; pfam00162 316275002561 substrate binding site [chemical binding]; other site 316275002562 hinge regions; other site 316275002563 ADP binding site [chemical binding]; other site 316275002564 catalytic site [active] 316275002565 PS00111 Phosphoglycerate kinase signature. 316275002566 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 316275002567 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 316275002568 active site 316275002569 intersubunit interface [polypeptide binding]; other site 316275002570 zinc binding site [ion binding]; other site 316275002571 Na+ binding site [ion binding]; other site 316275002572 HMMPfam hit to PF01116, Fructose-bisphosphate aldolase class-II, score 1.4e-199 316275002573 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 316275002574 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 316275002575 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275002576 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316275002577 ATP binding site [chemical binding]; other site 316275002578 Mg++ binding site [ion binding]; other site 316275002579 motif III; other site 316275002580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275002581 nucleotide binding region [chemical binding]; other site 316275002582 ATP-binding site [chemical binding]; other site 316275002583 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 5.1e-36 316275002584 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1.8e-64 316275002585 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275002586 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002587 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 316275002588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275002589 S-adenosylmethionine binding site [chemical binding]; other site 316275002590 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 316275002591 HMMPfam hit to PF05175, Methyltransferase small domain, score 2.9e-06 316275002592 HMMPfam hit to PF08242, Methyltransferase domain,score 4.2e-06 316275002593 PS00092 N-6 Adenine-specific DNA methylases signature. 316275002594 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 316275002595 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 2.7e-206 316275002597 flavodoxin FldB; Provisional; Region: PRK12359 316275002598 HMMPfam hit to PF00258, Flavodoxin, score 5.7e-37 316275002599 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002600 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 316275002601 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 316275002602 active site 316275002603 Int/Topo IB signature motif; other site 316275002604 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 1.6e-26 316275002605 HMMPfam hit to PF00589, Phage integrase family,score 3.1e-65 316275002606 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 316275002607 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 316275002608 dimerization domain [polypeptide binding]; other site 316275002609 dimer interface [polypeptide binding]; other site 316275002610 catalytic residues [active] 316275002611 PS00194 Thioredoxin family active site. 316275002612 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 316275002613 DHH family; Region: DHH; pfam01368 316275002614 DHHA1 domain; Region: DHHA1; pfam02272 316275002615 HMMPfam hit to PF01368, DHH family, score 1.3e-51 316275002616 HMMPfam hit to PF02272, DHHA1 domain, score 1.8e-16 316275002617 Similar to Salmonella typhimurium Peptide chain release factor 2 PrfB (RF-2) UniProt:P0A289 (365 aa) fasta scores: E()=2.3e-90, 80.935% id in 278 aa. Contains a framshift after codon 25. The sequence has been checked and is believed to be correct 316275002618 HMMPfam hit to PF03462, PCRF domain, score 7e-53 316275002619 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 6.6e-71 316275002620 PS00745 Prokaryotic-type class I peptide chain release factors signature. 316275002621 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 316275002622 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 316275002623 dimer interface [polypeptide binding]; other site 316275002624 putative anticodon binding site; other site 316275002625 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 316275002626 motif 1; other site 316275002627 active site 316275002628 motif 2; other site 316275002629 motif 3; other site 316275002630 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 4.4e-13 316275002631 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 6.6e-127 316275002632 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275002633 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275002634 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316275002635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275002636 Walker A motif; other site 316275002637 ATP binding site [chemical binding]; other site 316275002638 Walker B motif; other site 316275002639 arginine finger; other site 316275002640 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316275002641 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.1e-75 316275002642 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 316275002643 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275002644 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 6.1e-08 316275002645 Predicted helix-turn-helix motif with score 1644.000, SD 4.79 at aa 412-433, sequence GQVSSAAKELGVSRATMYRLLN 316275002646 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 316275002647 putative DNA-binding cleft [nucleotide binding]; other site 316275002648 putative DNA clevage site; other site 316275002649 molecular lever; other site 316275002650 HMMPfam hit to PF02976, DNA mismatch repair enzyme MutH, score 1.7e-40 316275002651 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 316275002652 putative active site [active] 316275002653 Ap4A binding site [chemical binding]; other site 316275002654 nudix motif; other site 316275002655 putative metal binding site [ion binding]; other site 316275002656 HMMPfam hit to PF00293, NUDIX domain, score 3.9e-28 316275002657 PS00893 mutT domain signature. 316275002658 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 316275002659 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316275002660 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 316275002661 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316275002662 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316275002663 HMMPfam hit to PF01590, GAF domain, score 3.5e-23 316275002664 HMMPfam hit to PF05524, PEP-utilising enzyme,N-terminal, score 6.2e-38 316275002665 HMMPfam hit to PF00391, PEP-utilising enzyme,mobile domain, score 2.6e-20 316275002666 PS00370 PEP-utilizing enzymes phosphorylation site signature. 316275002667 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 1.8e-123 316275002668 PS00742 PEP-utilizing enzymes signature 2. 316275002669 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316275002671 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 6.4e-39 316275002672 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 316275002673 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 9.1e-142 316275002675 PS01311 Prolipoprotein diacylglyceryl transferase signature. 316275002676 thymidylate synthase; Reviewed; Region: thyA; PRK01827 316275002677 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 316275002678 dimerization interface [polypeptide binding]; other site 316275002679 active site 316275002680 HMMPfam hit to PF00303, Thymidylate synthase, score 9.7e-52 316275002681 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 316275002682 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 316275002683 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 316275002685 HMMPfam hit to PF02690, Na+/Pi-cotransporter score 5.4e-25 316275002686 HMMPfam hit to PF02690, Na+/Pi-cotransporter score 1.4e-56 316275002687 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 316275002688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275002689 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 316275002690 putative dimerization interface [polypeptide binding]; other site 316275002691 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.4e-18 316275002692 Predicted helix-turn-helix motif with score 1368.000, SD 3.85 at aa 32-53, sequence GSVTKAAEALFLTPQTVTGQIK 316275002693 PS00044 Bacterial regulatory proteins, lysR family signature. 316275002694 HMMPfam hit to PF03466, LysR substrate binding domain, score 0.00017 316275002695 dimerization interface [polypeptide binding]; other site 316275002696 putative DNA binding site [nucleotide binding]; other site 316275002697 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 316275002698 putative Zn2+ binding site [ion binding]; other site 316275002699 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 1.4e-15 316275002700 Predicted helix-turn-helix motif with score 1737.000, SD 5.10 at aa 42-63, sequence LSVGQIAEQLSLSQSALSQHLG 316275002701 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 316275002702 HMMPfam hit to PF01649, Ribosomal protein S20,score 5.4e-42 316275002703 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 316275002704 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 316275002706 HMMPfam hit to PF03023, MviN-like protein, score 3.3e-167 316275002707 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 316275002708 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 316275002709 active site 316275002710 Riboflavin kinase; Region: Flavokinase; smart00904 316275002711 HMMPfam hit to PF06574, FAD synthetase, score 3.8e-86 316275002712 HMMPfam hit to PF01687, Riboflavin kinase, score 6.7e-49 316275002713 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 316275002714 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316275002715 active site 316275002716 HIGH motif; other site 316275002717 nucleotide binding site [chemical binding]; other site 316275002718 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 316275002719 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 316275002720 active site 316275002721 KMSKS motif; other site 316275002722 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 316275002723 tRNA binding surface [nucleotide binding]; other site 316275002724 anticodon binding site; other site 316275002725 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 316275002726 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 0 316275002727 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275002728 HMMPfam hit to PF08264, Anticodon-binding domain,score 1e-54 316275002729 HMMPfam hit to PF06827, Zinc finger found in FPG and IleRS, score 8.8e-10 316275002730 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 316275002732 HMMPfam hit to PF01252, Signal peptidase (SPase) II, score 2.7e-69 316275002733 PS00855 Signal peptidases II signature. 316275002734 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 316275002735 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316275002736 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 0.00067 316275002737 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 316275002738 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 316275002739 HMMPfam hit to PF02401, LytB protein, score 2.1e-164 316275002740 dihydrodipicolinate reductase; Provisional; Region: PRK00048 316275002741 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 316275002742 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 316275002743 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 2.5e-57 316275002744 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 1.1e-78 316275002745 PS01298 Dihydrodipicolinate reductase signature. 316275002746 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 316275002747 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 316275002748 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 316275002749 catalytic site [active] 316275002750 subunit interface [polypeptide binding]; other site 316275002751 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase small ch, score 8e-94 316275002752 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2e-70 316275002753 PS00442 Glutamine amidotransferases class-I active site. 316275002754 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 316275002755 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316275002756 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 316275002757 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 316275002758 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316275002759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316275002760 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 316275002761 IMP binding site; other site 316275002762 dimer interface [polypeptide binding]; other site 316275002763 interdomain contacts; other site 316275002764 partial ornithine binding site; other site 316275002765 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 9.5e-62 316275002766 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 1.2e-130 316275002767 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 316275002768 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 316275002769 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large c, score 4.6e-66 316275002770 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 1e-27 316275002771 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 2.7e-25 316275002772 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 316275002773 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 316275002774 HMMPfam hit to PF02142, MGS-like domain, score 1.4e-27 316275002775 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 316275002776 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 316275002777 HMMPfam hit to PF02113, D-Ala-D-Ala carboxypeptidase 3 (S13) fa, score 2.3e-75 316275002778 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 316275002779 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 316275002780 eyelet of channel; other site 316275002781 trimer interface [polypeptide binding]; other site 316275002782 HMMPfam hit to PF00267, Gram-negative porin, score 4.5e-09 316275002783 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 316275002784 HMMPfam hit to PF03449, Prokaryotic transcription elongation fact, score 8.7e-30 316275002785 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 316275002786 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 316275002787 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 316275002788 PS00829 Prokaryotic transcription elongation factors signature 1. 316275002789 HMMPfam hit to PF01272, Prokaryotic transcription elongation fact, score 1.1e-37 316275002790 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 316275002791 HMMPfam hit to PF01985, CRS1 / YhbY domain, score 4.5e-33 316275002792 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 316275002793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275002794 S-adenosylmethionine binding site [chemical binding]; other site 316275002795 HMMPfam hit to PF01728, FtsJ-like methyltransferase, score 2.2e-79 316275002796 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 316275002797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275002798 Walker A motif; other site 316275002799 ATP binding site [chemical binding]; other site 316275002800 Walker B motif; other site 316275002801 arginine finger; other site 316275002802 Peptidase family M41; Region: Peptidase_M41; pfam01434 316275002804 HMMPfam hit to PF06480, FtsH Extracellular, score 5e-44 316275002805 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002806 HMMPfam hit to PF00004, ATPase family associated with various c, score 2.4e-98 316275002807 HMMPfam hit to PF07728, ATPase family associated with various c, score 0.00027 316275002808 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002809 PS00674 AAA-protein family signature. 316275002810 HMMPfam hit to PF01434, Peptidase family M41, score 1.3e-117 316275002811 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 316275002812 dihydropteroate synthase; Region: DHPS; TIGR01496 316275002813 substrate binding pocket [chemical binding]; other site 316275002814 dimer interface [polypeptide binding]; other site 316275002815 inhibitor binding site; inhibition site 316275002816 PS00792 Dihydropteroate synthase signature 1. 316275002817 HMMPfam hit to PF00809, Pterin binding enzyme,score 7.5e-98 316275002818 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 316275002819 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 316275002820 active site 316275002821 substrate binding site [chemical binding]; other site 316275002822 metal binding site [ion binding]; metal-binding site 316275002823 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 1.1e-58 316275002824 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 316275002825 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 2.5e-46 316275002826 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 1.1e-31 316275002827 HMMPfam hit to PF00408,Phosphoglucomutase/phosphomannomutase, C-, score 4.5e-10 316275002828 Preprotein translocase SecG subunit; Region: SecG; pfam03840 316275002829 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 2.1e-34 316275002831 ribosome maturation protein RimP; Reviewed; Region: PRK00092 316275002832 Sm and related proteins; Region: Sm_like; cl00259 316275002833 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 316275002834 putative oligomer interface [polypeptide binding]; other site 316275002835 putative RNA binding site [nucleotide binding]; other site 316275002836 HMMPfam hit to PF02576, Uncharacterised BCR, YhbC family COG0779, score 1.3e-66 316275002837 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 316275002838 NusA N-terminal domain; Region: NusA_N; pfam08529 316275002839 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 316275002840 RNA binding site [nucleotide binding]; other site 316275002841 homodimer interface [polypeptide binding]; other site 316275002842 NusA-like KH domain; Region: KH_5; pfam13184 316275002843 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 316275002844 G-X-X-G motif; other site 316275002845 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 316275002846 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 316275002847 HMMPfam hit to PF08529, NusA N-terminal domain,score 5.3e-55 316275002848 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.8e-09 316275002849 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 316275002850 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 316275002851 translation initiation factor IF-2; Region: IF-2; TIGR00487 316275002852 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 316275002853 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 316275002854 G1 box; other site 316275002855 putative GEF interaction site [polypeptide binding]; other site 316275002856 GTP/Mg2+ binding site [chemical binding]; other site 316275002857 Switch I region; other site 316275002858 G2 box; other site 316275002859 G3 box; other site 316275002860 Switch II region; other site 316275002861 G4 box; other site 316275002862 G5 box; other site 316275002863 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 316275002864 Translation-initiation factor 2; Region: IF-2; pfam11987 316275002865 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 316275002866 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 9.9e-05 316275002867 HMMPfam hit to PF08364, Bacterial translation initiation factor I, score 1.2e-21 316275002868 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 3.1e-18 316275002869 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 4.1e-54 316275002870 PS00017 ATP/GTP-binding site motif A (P-loop). 316275002871 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.5e-13 316275002872 HMMPfam hit to PF03144, Elongation factor Tu domain, score 3.6e-10 316275002873 PS01176 Initiation factor 2 signature. 316275002874 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 316275002875 HMMPfam hit to PF02033, Ribosome-binding factor A,score 1.4e-41 316275002876 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 316275002877 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 316275002878 RNA binding site [nucleotide binding]; other site 316275002879 active site 316275002880 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 316275002881 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 6.6e-77 316275002882 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 316275002883 16S/18S rRNA binding site [nucleotide binding]; other site 316275002884 S13e-L30e interaction site [polypeptide binding]; other site 316275002885 25S rRNA binding site [nucleotide binding]; other site 316275002886 HMMPfam hit to PF00312, Ribosomal protein S15,score 3.7e-36 316275002887 PS00362 Ribosomal protein S15 signature. 316275002888 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 316275002889 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 316275002890 RNase E interface [polypeptide binding]; other site 316275002891 trimer interface [polypeptide binding]; other site 316275002892 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 316275002893 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 316275002894 RNase E interface [polypeptide binding]; other site 316275002895 trimer interface [polypeptide binding]; other site 316275002896 active site 316275002897 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 316275002898 putative nucleic acid binding region [nucleotide binding]; other site 316275002899 G-X-X-G motif; other site 316275002900 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 316275002901 RNA binding site [nucleotide binding]; other site 316275002902 domain interface; other site 316275002903 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 5.5e-39 316275002904 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 3.8e-15 316275002905 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 3.8e-35 316275002906 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 2.6e-51 316275002907 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 6.1e-21 316275002908 HMMPfam hit to PF00013, KH domain, score 7.8e-16 316275002909 HMMPfam hit to PF00575, S1 RNA binding domain,score 6.1e-21 316275002910 lipoprotein NlpI; Provisional; Region: PRK11189 316275002911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275002912 binding surface 316275002913 TPR motif; other site 316275002914 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275002915 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.034 316275002916 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 8.8e-05 316275002917 putative protease; Provisional; Region: PRK15447 316275002918 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 316275002919 HMMPfam hit to PF01136, Peptidase family U32, score 1.3e-08 316275002920 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 316275002921 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 316275002922 Peptidase family U32; Region: Peptidase_U32; pfam01136 316275002923 HMMPfam hit to PF01136, Peptidase family U32, score 7.5e-117 316275002924 PS01276 Peptidase family U32 signature. 316275002925 PAS fold; Region: PAS_4; pfam08448 316275002926 PAS domain; Region: PAS_8; pfam13188 316275002927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275002928 metal binding site [ion binding]; metal-binding site 316275002929 active site 316275002930 I-site; other site 316275002931 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275002932 HMMPfam hit to PF00563, EAL domain, score 2.3e-108 316275002933 HMMPfam hit to PF00990, GGDEF domain, score 3e-40 316275002934 HMMPfam hit to PF08448, PAS fold, score 5.2e-08 316275002935 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 316275002936 HMMPfam hit to PF02036, SCP-2 sterol transfer family, score 1.4e-10 316275002937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275002938 Coenzyme A binding pocket [chemical binding]; other site 316275002939 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.8e-11 316275002942 DNA polymerase III psi subunit; Region: DNA_III_psi; pfam03603 316275002943 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 316275002944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275002945 Coenzyme A binding pocket [chemical binding]; other site 316275002946 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.7e-18 316275002947 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 316275002948 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 316275002949 G1 box; other site 316275002950 putative GEF interaction site [polypeptide binding]; other site 316275002951 GTP/Mg2+ binding site [chemical binding]; other site 316275002952 Switch I region; other site 316275002953 G2 box; other site 316275002954 G3 box; other site 316275002955 Switch II region; other site 316275002956 G4 box; other site 316275002957 G5 box; other site 316275002958 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 316275002959 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.5e-58 316275002960 PS00301 GTP-binding elongation factors signature. 316275002961 HMMPfam hit to PF03144, Elongation factor Tu domain, score 5.8e-08 316275002962 PS00237 G-protein coupled receptors signature. 316275002963 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 316275002964 active site 316275002965 HMMPfam hit to PF01026, TatD related DNase, score 1.6e-91 316275002966 PS01137 Uncharacterized protein family UPF0006 signature 1. 316275002967 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 316275002968 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 316275002969 Nucleoside recognition; Region: Gate; pfam07670 316275002970 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 316275002971 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 7e-35 316275002973 HMMPfam hit to PF07670, Nucleoside recognition,score 1.5e-17 316275002974 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 8.9e-109 316275002975 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275002976 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275002977 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275002978 HMMPfam hit to PF01609, Transposase DDE domain,score 7.6e-28 316275002979 XapX domain; Region: XapX; TIGR03510 316275002981 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 316275002982 intersubunit interface [polypeptide binding]; other site 316275002983 active site 316275002984 catalytic residue [active] 316275002985 HMMPfam hit to PF01791, DeoC/LacD family aldolase,score 6.2e-72 316275002986 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 316275002987 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316275002988 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 316275002989 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 316275002990 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 1.9e-15 316275002991 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 2.2e-59 316275002992 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 316275002993 HMMPfam hit to PF07831, Pyrimidine nucleoside phosphorylase C, score 3.7e-31 316275002994 phosphopentomutase; Provisional; Region: PRK05362 316275002995 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 316275002996 HMMPfam hit to PF08342, Phosphopentomutase N-terminal, score 3.9e-66 316275002997 HMMPfam hit to PF01676, Metalloenzyme superfamily,score 2.3e-39 316275002998 Similar to Escherichia coli Purine nucleoside phosphorylase DeoD-type UniProt:P0ABP8 (238 aa) fasta scores: E()=2.4e-10, 83.333% id in 42 aa. CDS contains a nonsense mutation (CGA or AGA to UGA) after codon 43. The sequence has been checked and is believed to be correct 316275002999 HMMPfam hit to PF01048, Phosphorylase family, score 4.8e-94 316275003000 PS01232 Purine and other phosphorylases family 1 signature. 316275003001 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 316275003003 PS00589 PTS HPR component serine phosphorylation site signature. 316275003004 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 316275003005 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 316275003006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275003007 motif II; other site 316275003008 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.5e-24 316275003009 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 0.00014 316275003010 PilZ domain; Region: PilZ; pfam07238 316275003011 PilZ domain; Region: PilZ; pfam07238 316275003012 HMMPfam hit to PF07238, PilZ domain, score 0.00032 316275003013 HMMPfam hit to PF07238, PilZ domain, score 5.1e-08 316275003014 DNA repair protein RadA; Provisional; Region: PRK11823 316275003015 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 316275003016 Walker A motif/ATP binding site; other site 316275003017 ATP binding site [chemical binding]; other site 316275003018 Walker B motif; other site 316275003019 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 316275003020 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003021 elongation factor G; Reviewed; Region: PRK00007 316275003022 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 316275003023 G1 box; other site 316275003024 putative GEF interaction site [polypeptide binding]; other site 316275003025 GTP/Mg2+ binding site [chemical binding]; other site 316275003026 Switch I region; other site 316275003027 G2 box; other site 316275003028 G3 box; other site 316275003029 Switch II region; other site 316275003030 G4 box; other site 316275003031 G5 box; other site 316275003032 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 316275003033 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 316275003034 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 316275003035 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 2.1e-99 316275003036 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003037 PS00301 GTP-binding elongation factors signature. 316275003038 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.8e-17 316275003039 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 6.3e-57 316275003040 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 2.9e-45 316275003041 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 316275003042 cytosine deaminase; Provisional; Region: PRK09230 316275003043 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 316275003044 active site 316275003045 HMMPfam hit to PF07969, Amidohydrolase family,score 9.4e-70 316275003046 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 316275003047 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 316275003048 Na binding site [ion binding]; other site 316275003049 putative substrate binding site [chemical binding]; other site 316275003050 HMMPfam hit to PF02133, Permease for cytosine/purines, uracil,, score 2.9e-79 316275003052 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 316275003053 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 316275003054 acyl-activating enzyme (AAE) consensus motif; other site 316275003055 putative AMP binding site [chemical binding]; other site 316275003056 putative active site [active] 316275003057 putative CoA binding site [chemical binding]; other site 316275003058 HMMPfam hit to PF00501, AMP-binding enzyme, score 3.6e-76 316275003059 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275003060 PS00455 AMP-binding domain signature. 316275003061 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 316275003062 MutS domain I; Region: MutS_I; pfam01624 316275003063 MutS domain II; Region: MutS_II; pfam05188 316275003064 MutS domain III; Region: MutS_III; pfam05192 316275003065 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 316275003066 Walker A/P-loop; other site 316275003067 ATP binding site [chemical binding]; other site 316275003068 Q-loop/lid; other site 316275003069 ABC transporter signature motif; other site 316275003070 Walker B; other site 316275003071 D-loop; other site 316275003072 H-loop/switch region; other site 316275003073 HMMPfam hit to PF00488, MutS domain V, score 3.5e-166 316275003074 PS00486 DNA mismatch repair proteins mutS family signature. 316275003075 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003076 Predicted helix-turn-helix motif with score 981.000, SD 2.53 at aa 546-567, sequence SNLAERADTLNYCRPTLSSDIG 316275003077 HMMPfam hit to PF05192, MutS domain III, score 4.8e-93 316275003078 HMMPfam hit to PF05190, MutS family domain IV,score 2.8e-40 316275003079 HMMPfam hit to PF05188, MutS domain II, score 3e-45 316275003080 HMMPfam hit to PF01624, MutS domain I, score 9.9e-68 316275003081 Competence-damaged protein; Region: CinA; cl00666 316275003082 HMMPfam hit to PF02464, Competence-damaged protein,score 2e-63 316275003083 recombinase A; Provisional; Region: recA; PRK09354 316275003084 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 316275003085 hexamer interface [polypeptide binding]; other site 316275003086 Walker A motif; other site 316275003087 ATP binding site [chemical binding]; other site 316275003088 Walker B motif; other site 316275003089 HMMPfam hit to PF00154, recA bacterial DNA recombination protein, score 4e-243 316275003090 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003091 PS00321 recA signature. 316275003092 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 316275003093 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 316275003094 motif 1; other site 316275003095 active site 316275003096 motif 2; other site 316275003097 motif 3; other site 316275003098 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 316275003099 DHHA1 domain; Region: DHHA1; pfam02272 316275003100 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 316275003101 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275003102 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase seco, score 6.5e-21 316275003103 HMMPfam hit to PF02272, DHHA1 domain, score 4.5e-21 316275003104 aspartate kinase; Validated; Region: PRK08841 316275003105 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 316275003106 putative nucleotide binding site [chemical binding]; other site 316275003107 putative catalytic residues [active] 316275003108 putative Mg ion binding site [ion binding]; other site 316275003109 putative aspartate binding site [chemical binding]; other site 316275003110 HMMPfam hit to PF00696, Amino acid kinase family,score 6.2e-70 316275003111 PS00324 Aspartokinase signature. 316275003112 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275003113 carbon storage regulator; Provisional; Region: PRK01712 316275003114 HMMPfam hit to PF02599, Global regulator protein family, score 9.4e-30 316275003115 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK03814 316275003116 HMMPfam hit to PF04277, Oxaloacetate decarboxylase,gamma chain, score 3.3e-23 316275003118 oxaloacetate decarboxylase; Provisional; Region: PRK14040 316275003119 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 316275003120 active site 316275003121 catalytic residues [active] 316275003122 metal binding site [ion binding]; metal-binding site 316275003123 homodimer binding site [polypeptide binding]; other site 316275003124 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316275003125 carboxyltransferase (CT) interaction site; other site 316275003126 biotinylation site [posttranslational modification]; other site 316275003127 HMMPfam hit to PF00682, HMGL-like, score 2.2e-68 316275003128 HMMPfam hit to PF02436, Conserved carboxylase domain, score 1.1e-75 316275003129 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 3.4e-23 316275003130 PS00188 Biotin-requiring enzymes attachment site. 316275003131 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 316275003133 HMMPfam hit to PF03977, Na+-transporting methylmalonyl-CoA/oxaloacet, score 2.4e-274 316275003134 Predicted membrane protein [Function unknown]; Region: COG1238 316275003136 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316275003137 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316275003138 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316275003139 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316275003140 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316275003141 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316275003142 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 2.3e-06 316275003143 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003144 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.2e-43 316275003145 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 9.8e-26 316275003146 glutamate--cysteine ligase; Provisional; Region: PRK02107 316275003147 HMMPfam hit to PF04262, Glutamate-cysteine ligase,score 1.2e-232 316275003148 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275003149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275003150 catalytic residue [active] 316275003151 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003152 S-ribosylhomocysteinase; Provisional; Region: PRK02260 316275003153 HMMPfam hit to PF02664, S-Ribosylhomocysteinase (LuxS), score 5.7e-103 316275003154 Domain of unknown function DUF21; Region: DUF21; pfam01595 316275003155 hypothetical protein; Provisional; Region: PRK11573 316275003156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316275003157 Transporter associated domain; Region: CorC_HlyC; smart01091 316275003158 HMMPfam hit to PF03471, Transporter associated domain, score 5.2e-13 316275003159 HMMPfam hit to PF00571, CBS domain pair, score 5.6e-18 316275003160 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 9.1e-68 316275003162 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 316275003163 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 1e-66 316275003165 signal recognition particle protein; Provisional; Region: PRK10867 316275003166 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 316275003167 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316275003168 P loop; other site 316275003169 GTP binding site [chemical binding]; other site 316275003170 Signal peptide binding domain; Region: SRP_SPB; pfam02978 316275003171 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 4.7e-34 316275003172 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 2.1e-113 316275003173 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003174 PS00300 SRP54-type proteins GTP-binding domain signature. 316275003175 HMMPfam hit to PF02978, Signal peptide binding domain, score 2.5e-47 316275003176 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 316275003177 PS00732 Ribosomal protein S16 signature. 316275003178 HMMPfam hit to PF00886, Ribosomal protein S16,score 5.1e-27 316275003179 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 316275003180 RimM N-terminal domain; Region: RimM; pfam01782 316275003181 PRC-barrel domain; Region: PRC; pfam05239 316275003182 HMMPfam hit to PF01782, RimM N-terminal domain,score 6e-28 316275003183 HMMPfam hit to PF05239, PRC-barrel domain, score 3.7e-16 316275003184 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 316275003185 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 2.4e-81 316275003186 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 316275003187 HMMPfam hit to PF01245, Ribosomal protein L19,score 3.5e-73 316275003188 PS01015 Ribosomal protein L19 signature. 316275003189 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 316275003190 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 316275003191 HMMPfam hit to PF00793, DAHP synthetase I family,score 3.3e-156 316275003192 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 316275003193 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 316275003194 prephenate dehydrogenase; Validated; Region: PRK08507 316275003195 HMMPfam hit to PF01817, Chorismate mutase type II,score 6.2e-32 316275003196 HMMPfam hit to PF02153, Prephenate dehydrogenase,score 4.8e-24 316275003197 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 316275003198 Peptidase family M23; Region: Peptidase_M23; pfam01551 316275003199 HMMPfam hit to PF01551, Peptidase family M23, score 5.8e-46 316275003201 PilZ domain; Region: PilZ; pfam07238 316275003202 HMMPfam hit to PF07238, PilZ domain, score 2.1e-15 316275003203 Similar to Escherichia coli ABC transporter ATP-binding protein YjjK UniProt:P0A9W3 (554 aa) fasta scores: E()=1.3e-78, 79.009% id in 343 aa. CDS contains a frameshift after codon 192. The sequence has been checked and is believed to be correct 316275003204 HMMPfam hit to PF00005, ABC transporter score 2.4e-49 316275003205 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003206 HMMPfam hit to PF00005, ABC transporter score 2.5e-51 316275003207 PS00211 ABC transporters family signature. 316275003208 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003209 lytic murein transglycosylase; Provisional; Region: PRK11619 316275003210 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275003211 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275003212 catalytic residue [active] 316275003213 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 2.1e-28 316275003214 PS00922 Prokaryotic transglycosylases signature. 316275003215 Trp operon repressor; Provisional; Region: PRK01381 316275003216 HMMPfam hit to PF01371, Trp repressor protein,score 1.4e-37 316275003217 Predicted helix-turn-helix motif with score 1443.000, SD 4.10 at aa 57-78, sequence LSQRQISQLLGVGVATITRGSN 316275003218 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 316275003219 HMMPfam hit to PF01931, Protein of unknown function DUF84, score 1.4e-45 316275003220 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 316275003221 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 316275003222 Prephenate dehydratase; Region: PDT; pfam00800 316275003223 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 316275003224 putative L-Phe binding site [chemical binding]; other site 316275003225 PS00858 Prephenate dehydratase signature 2. 316275003226 HMMPfam hit to PF00800, Prephenate dehydratase,score 1.3e-70 316275003227 PS00857 Prephenate dehydratase signature 1. 316275003228 HMMPfam hit to PF01817, Chorismate mutase type II,score 2.5e-28 316275003229 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 316275003230 30S subunit binding site; other site 316275003231 HMMPfam hit to PF02482, Sigma 54 modulation protein / S30EA r, score 1.6e-18 316275003232 Outer membrane lipoprotein; Region: YfiO; pfam13525 316275003233 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275003234 Predicted helix-turn-helix motif with score 1086.000, SD 2.89 at aa 81-102, sequence YSQAQISLQAGNWTSAVERLEA 316275003235 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003236 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 316275003237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275003238 RNA binding surface [nucleotide binding]; other site 316275003239 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316275003240 active site 316275003241 HMMPfam hit to PF01479, S4 domain, score 3e-06 316275003242 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.9e-66 316275003243 PS01129 Rlu family of pseudouridine synthase signature. 316275003244 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 316275003245 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 316275003246 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 1.3e-69 316275003247 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 316275003248 Clp amino terminal domain; Region: Clp_N; pfam02861 316275003249 Clp amino terminal domain; Region: Clp_N; pfam02861 316275003250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275003251 Walker A motif; other site 316275003252 ATP binding site [chemical binding]; other site 316275003253 Walker B motif; other site 316275003254 arginine finger; other site 316275003255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275003256 Walker A motif; other site 316275003257 ATP binding site [chemical binding]; other site 316275003258 Walker B motif; other site 316275003259 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316275003260 HMMPfam hit to PF02861, Clp amino terminal domain,score 3.4e-14 316275003261 HMMPfam hit to PF02861, Clp amino terminal domain,score 8e-13 316275003262 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.1e-10 316275003263 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003264 PS00870 Chaperonins clpA/B signature 1. 316275003265 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.7e-112 316275003266 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.3e-05 316275003267 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003268 PS00871 Chaperonins clpA/B signature 2. 316275003269 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 316275003270 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.1e-05 316275003272 PS00409 Prokaryotic N-terminal methylation site. 316275003274 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 316275003276 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 316275003277 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 316275003279 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.3e-08 316275003280 PS00409 Prokaryotic N-terminal methylation site. 316275003281 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 316275003282 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 316275003283 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 3.8e-09 316275003284 PS00409 Prokaryotic N-terminal methylation site. 316275003286 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 316275003287 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 316275003288 Chromate transporter; Region: Chromate_transp; pfam02417 316275003290 HMMPfam hit to PF02417, Chromate transporter score 2.5e-08 316275003291 HMMPfam hit to PF02417, Chromate transporter score 3.5e-25 316275003292 Similar to Pseudomonas aeruginosa MexT protein UniProt:O87785 (304 aa) fasta scores: E()=8.4e-21, 29.930% id in 284 aa. CDS contains a nonsense mutation (GAA or GAG to TAA) after codon 19. The sequence has been checked and is believed to be correct 316275003293 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.2e-15 316275003294 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-17 316275003296 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 316275003297 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 316275003298 putative trimer interface [polypeptide binding]; other site 316275003299 putative CoA binding site [chemical binding]; other site 316275003300 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003301 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 21 316275003302 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.83 316275003303 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.1e+02 316275003304 DNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS , pqiA [General function prediction only]; Region: COG3141 316275003305 HMMPfam hit to PF07130, YebG protein, score 1.4e-41 316275003306 Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053 316275003307 diiron binding motif [ion binding]; other site 316275003308 HMMPfam hit to PF01786, Alternative oxidase, score 6.3e-63 316275003310 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 316275003311 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275003312 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 316275003313 putative dimerization interface [polypeptide binding]; other site 316275003314 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.2e-40 316275003315 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.5e-15 316275003316 PS00044 Bacterial regulatory proteins, lysR family signature. 316275003317 Predicted helix-turn-helix motif with score 1166.000, SD 3.16 at aa 18-39, sequence KTMTKAAERLFITKPAVSLSLS 316275003318 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 316275003319 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 316275003320 gating phenylalanine in ion channel; other site 316275003322 HMMPfam hit to PF03595, C4-dicarboxylate transporter/malic aci, score 3.2e-77 316275003323 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 316275003324 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 316275003325 HMMPfam hit to PF04257, Exodeoxyribonuclease V,gamma subunit, score 0 316275003326 PS00304 Small, acid-soluble spore proteins,alpha/beta type, signature 1. 316275003327 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 316275003328 Part of AAA domain; Region: AAA_19; pfam13245 316275003329 Family description; Region: UvrD_C_2; pfam13538 316275003330 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 316275003331 HMMPfam hit to PF00580, UvrD/REP helicase, score 3.9e-98 316275003332 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003333 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 316275003334 AAA domain; Region: AAA_30; pfam13604 316275003335 Family description; Region: UvrD_C_2; pfam13538 316275003336 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003337 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 316275003338 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 316275003340 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 2.8e-131 316275003341 PS00217 Sugar transport proteins signature 2. 316275003342 argininosuccinate lyase; Provisional; Region: PRK00855 316275003343 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 316275003344 active sites [active] 316275003345 tetramer interface [polypeptide binding]; other site 316275003346 HMMPfam hit to PF00206, Lyase, score 2e-80 316275003347 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003348 PS00163 Fumarate lyases signature. 316275003349 N-acetylglutamate synthase; Validated; Region: PRK05279 316275003350 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 316275003351 putative feedback inhibition sensing region; other site 316275003352 putative nucleotide binding site [chemical binding]; other site 316275003353 putative substrate binding site [chemical binding]; other site 316275003354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275003355 Coenzyme A binding pocket [chemical binding]; other site 316275003356 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-07 316275003357 HMMPfam hit to PF00696, Amino acid kinase family,score 2.3e-16 316275003358 Protein of unknown function (DUF2850); Region: DUF2850; pfam11012 316275003360 murein transglycosylase A; Provisional; Region: mltA; PRK11162 316275003361 MltA specific insert domain; Region: MltA; smart00925 316275003362 3D domain; Region: 3D; pfam06725 316275003363 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003364 HMMPfam hit to PF03562, MltA N-terminal domain,score 1.3e-86 316275003365 HMMPfam hit to PF06725, 3D domain, score 9.3e-22 316275003366 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 316275003367 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 316275003368 putative ATP binding site [chemical binding]; other site 316275003369 putative substrate interface [chemical binding]; other site 316275003370 HMMPfam hit to PF00899, ThiF family, score 2.3e-57 316275003372 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 316275003373 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 3.9e-40 316275003374 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316275003375 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 316275003376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275003377 catalytic residue [active] 316275003378 HMMPfam hit to PF00155, Aminotransferase class I and II, score 4.9e-05 316275003379 HMMPfam hit to PF00266, Aminotransferase class-V,score 2.6e-194 316275003380 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 316275003381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275003382 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 316275003383 dimerization interface [polypeptide binding]; other site 316275003384 substrate binding pocket [chemical binding]; other site 316275003385 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.4e-21 316275003386 Predicted helix-turn-helix motif with score 1791.000, SD 5.29 at aa 21-42, sequence LSFTRAAEELFVTQAAVSHQIK 316275003387 PS00044 Bacterial regulatory proteins, lysR family signature. 316275003388 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.3e-42 316275003389 Protein of unknown function (DUF423); Region: DUF423; pfam04241 316275003391 HMMPfam hit to PF04241, Protein of unknown function (DUF423), score 6.6e-45 316275003392 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 316275003393 FtsJ-like methyltransferase; Region: FtsJ; cl17430 316275003394 flap endonuclease-like protein; Provisional; Region: PRK09482 316275003395 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 316275003396 active site 316275003397 metal binding site 1 [ion binding]; metal-binding site 316275003398 putative 5' ssDNA interaction site; other site 316275003399 metal binding site 3; metal-binding site 316275003400 metal binding site 2 [ion binding]; metal-binding site 316275003401 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 316275003402 putative DNA binding site [nucleotide binding]; other site 316275003403 putative metal binding site [ion binding]; other site 316275003404 HMMPfam hit to PF01367, 5'-3' exonuclease,C-terminal SAM fold, score 3.4e-10 316275003405 HMMPfam hit to PF02739, 5'-3' exonuclease,N-terminal resolvase-, score 1.5e-13 316275003406 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 316275003407 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 316275003408 HMMPfam hit to PF03641, Possible lysine decarboxylase, score 3.5e-50 316275003409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275003410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275003411 metal binding site [ion binding]; metal-binding site 316275003412 active site 316275003413 I-site; other site 316275003414 HMMPfam hit to PF00990, GGDEF domain, score 9.2e-42 316275003415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275003416 binding surface 316275003417 TPR motif; other site 316275003418 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.17 316275003419 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.18 316275003421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 316275003422 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 316275003423 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 316275003424 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 4e-06 316275003425 SecY interacting protein Syd; Provisional; Region: PRK04968 316275003426 HMMPfam hit to PF07348, Syd protein, score 1.5e-97 316275003427 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 316275003428 hypothetical protein; Validated; Region: PRK00124 316275003429 HMMPfam hit to PF02639, Uncharacterized BCR,YaiI/YqxD family COG167, score 2e-64 316275003430 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 316275003431 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 316275003432 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 4.9e-87 316275003434 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 316275003435 active site 316275003436 P-loop; other site 316275003437 phosphorylation site [posttranslational modification] 316275003438 HMMPfam hit to PF02302, PTS system,Lactose/Cellobiose specific IIB, score 8.1e-35 316275003439 HMMPfam hit to PF00232, Glycosyl hydrolase family,score 4.8e-199 316275003440 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 316275003441 beta-galactosidase; Region: BGL; TIGR03356 316275003442 PS00572 Glycosyl hydrolases family 1 active site. 316275003443 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316275003444 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316275003445 nucleotide binding site [chemical binding]; other site 316275003446 HMMPfam hit to PF00480, ROK family, score 1.3e-24 316275003447 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 316275003448 methionine cluster; other site 316275003449 active site 316275003450 phosphorylation site [posttranslational modification] 316275003451 metal binding site [ion binding]; metal-binding site 316275003452 HMMPfam hit to PF02255, PTS system,Lactose/Cellobiose specific IIA, score 1e-38 316275003453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316275003454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275003455 DNA binding site [nucleotide binding] 316275003456 domain linker motif; other site 316275003457 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 316275003458 dimerization interface (closed form) [polypeptide binding]; other site 316275003459 ligand binding site [chemical binding]; other site 316275003460 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 3.4e-10 316275003461 Predicted helix-turn-helix motif with score 1625.000, SD 4.72 at aa 2-23, sequence ATINDVCKLAGVSKATVSRVMN 316275003462 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 3.3e-09 316275003463 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 316275003464 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 316275003465 Protein of unknown function (DUF3549); Region: DUF3549; pfam12069 316275003466 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 316275003467 HMMPfam hit to PF04287, Domain of unknown function,DUF446, score 1.4e-39 316275003468 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316275003469 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 316275003470 probable active site [active] 316275003471 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.6e-47 316275003472 PS01129 Rlu family of pseudouridine synthase signature. 316275003473 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 316275003474 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 316275003475 active site 316275003476 dimerization interface [polypeptide binding]; other site 316275003477 HMMPfam hit to PF00459, Inositol monophosphatase family, score 1.3e-75 316275003478 PS00629 Inositol monophosphatase family signature 1. 316275003479 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 316275003480 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 316275003481 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 1.2e-38 316275003482 Rrf2 family protein; Region: rrf2_super; TIGR00738 316275003483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275003484 dimerization interface [polypeptide binding]; other site 316275003485 putative Zn2+ binding site [ion binding]; other site 316275003486 putative DNA binding site [nucleotide binding]; other site 316275003487 HMMPfam hit to PF02082, Transcriptional regulator,score 3.9e-50 316275003488 Predicted helix-turn-helix motif with score 1222.000, SD 3.35 at aa 26-47, sequence VPLADISERQGISLSYLEQLFS 316275003489 PS01332 Uncharacterized protein family UPF0074 signature. 316275003490 cysteine desulfurase; Provisional; Region: PRK14012 316275003491 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 316275003492 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275003493 catalytic residue [active] 316275003494 HMMPfam hit to PF00266, Aminotransferase class-V,score 3.4e-119 316275003495 HMMPfam hit to PF01212, Beta-eliminating lyase,score 0.00059 316275003496 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 316275003497 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 316275003498 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 316275003499 trimerization site [polypeptide binding]; other site 316275003500 active site 316275003501 HMMPfam hit to PF01592, NifU-like N terminal domain, score 3.3e-77 316275003502 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 316275003503 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 4.8e-39 316275003504 PS01152 Hypothetical hesB/yadR/yfhF family signature. 316275003505 co-chaperone HscB; Provisional; Region: hscB; PRK05014 316275003506 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316275003507 HSP70 interaction site [polypeptide binding]; other site 316275003508 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 316275003509 HMMPfam hit to PF00226, DnaJ domain, score 5e-09 316275003510 HMMPfam hit to PF07743, HSCB C-terminal oligomerisation domain, score 1.4e-33 316275003511 chaperone protein HscA; Provisional; Region: hscA; PRK05183 316275003512 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 316275003513 nucleotide binding site [chemical binding]; other site 316275003514 putative NEF/HSP70 interaction site [polypeptide binding]; other site 316275003515 SBD interface [polypeptide binding]; other site 316275003516 HMMPfam hit to PF00012, Hsp70 protein, score 7.3e-236 316275003517 PS00297 Heat shock hsp70 proteins family signature 1. 316275003518 PS00329 Heat shock hsp70 proteins family signature 2. 316275003519 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 316275003520 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316275003521 catalytic loop [active] 316275003522 iron binding site [ion binding]; other site 316275003523 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 2.4e-21 316275003524 PS00814 Adrenodoxin family, iron-sulfur binding region signature. 316275003525 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 316275003526 HMMPfam hit to PF04384, Protein of unknown function (DUF528), score 9.8e-39 316275003527 aminopeptidase B; Provisional; Region: PRK05015 316275003528 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 316275003529 interface (dimer of trimers) [polypeptide binding]; other site 316275003530 Substrate-binding/catalytic site; other site 316275003531 Zn-binding sites [ion binding]; other site 316275003532 HMMPfam hit to PF00883, Cytosol aminopeptidase family, catalyti, score 1.6e-135 316275003533 PS00631 Cytosol aminopeptidase signature. 316275003534 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 316275003535 active site 316275003536 multimer interface [polypeptide binding]; other site 316275003537 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 7.7e-79 316275003538 PS00469 Nucleoside diphosphate kinases active site. 316275003539 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 316275003540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275003541 FeS/SAM binding site; other site 316275003542 HMMPfam hit to PF04055, Radical SAM superfamily,score 1e-10 316275003543 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 316275003544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275003545 TPR motif; other site 316275003546 binding surface 316275003547 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003548 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.16 316275003549 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.049 316275003550 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.16 316275003551 cytoskeletal protein RodZ; Provisional; Region: PRK10856 316275003552 Helix-turn-helix domain; Region: HTH_25; pfam13413 316275003553 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 316275003555 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 316275003556 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 316275003557 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 316275003558 HMMPfam hit to PF04551, GcpE protein, score 6.5e-236 316275003559 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 316275003560 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 316275003561 dimer interface [polypeptide binding]; other site 316275003562 motif 1; other site 316275003563 active site 316275003564 motif 2; other site 316275003565 motif 3; other site 316275003566 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 316275003567 anticodon binding site; other site 316275003568 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 7.3e-54 316275003569 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275003570 HMMPfam hit to PF03129, Anticodon binding domain,score 3.9e-12 316275003571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 316275003572 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 316275003573 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 316275003574 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 316275003575 Trp docking motif [polypeptide binding]; other site 316275003576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003577 HMMPfam hit to PF01011, PQQ enzyme repeat, score 2.6e-06 316275003578 HMMPfam hit to PF01011, PQQ enzyme repeat, score 1.3e-07 316275003579 GTP-binding protein Der; Reviewed; Region: PRK00093 316275003580 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 316275003581 G1 box; other site 316275003582 GTP/Mg2+ binding site [chemical binding]; other site 316275003583 Switch I region; other site 316275003584 G2 box; other site 316275003585 Switch II region; other site 316275003586 G3 box; other site 316275003587 G4 box; other site 316275003588 G5 box; other site 316275003589 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 316275003590 G1 box; other site 316275003591 GTP/Mg2+ binding site [chemical binding]; other site 316275003592 Switch I region; other site 316275003593 G2 box; other site 316275003594 G3 box; other site 316275003595 Switch II region; other site 316275003596 G4 box; other site 316275003597 G5 box; other site 316275003598 HMMPfam hit to PF01926, GTPase of unknown function,score 7.8e-48 316275003599 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003600 HMMPfam hit to PF01926, GTPase of unknown function,score 1.2e-44 316275003601 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003602 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 316275003603 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 316275003604 HMMPfam hit to PF07191, Protein of unknown function (DUF1407), score 1.1e-30 316275003605 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 316275003606 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 316275003607 generic binding surface II; other site 316275003608 generic binding surface I; other site 316275003609 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 6e-60 316275003610 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.5e-11 316275003611 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 316275003612 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 316275003613 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 316275003614 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 316275003615 active site 316275003616 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 8.8e-241 316275003617 HMMPfam hit to PF00571, CBS domain pair, score 2.7e-22 316275003618 PS00487 IMP dehydrogenase / GMP reductase signature. 316275003619 GMP synthase; Reviewed; Region: guaA; PRK00074 316275003620 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 316275003621 AMP/PPi binding site [chemical binding]; other site 316275003622 candidate oxyanion hole; other site 316275003623 catalytic triad [active] 316275003624 potential glutamine specificity residues [chemical binding]; other site 316275003625 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 316275003626 ATP Binding subdomain [chemical binding]; other site 316275003627 Ligand Binding sites [chemical binding]; other site 316275003628 Dimerization subdomain; other site 316275003629 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 5.7e-56 316275003630 PS00442 Glutamine amidotransferases class-I active site. 316275003631 HMMPfam hit to PF06508, ExsB, score 0.0026 316275003632 HMMPfam hit to PF00958, GMP synthase C terminal domain, score 4.7e-58 316275003633 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 316275003634 AbgT putative transporter family; Region: ABG_transport; pfam03806 316275003635 HMMPfam hit to PF03806, AbgT transporter family, score 0 316275003636 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 0.0039 316275003638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 316275003639 YheO-like PAS domain; Region: PAS_6; pfam08348 316275003640 HTH domain; Region: HTH_22; pfam13309 316275003641 Predicted helix-turn-helix motif with score 1056.000, SD 2.78 at aa 187-208, sequence DATQITANILNVSKDSVYRYLR 316275003642 HMMPfam hit to PF08348, YheO-like protein, score 9.9e-57 316275003643 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 316275003644 HMMPfam hit to PF06354, Protein of unknown function (DUF1063), score 3.5e-214 316275003645 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 316275003646 homotrimer interaction site [polypeptide binding]; other site 316275003647 putative active site [active] 316275003648 HMMPfam hit to PF01042, Endoribonuclease L-PSP,score 2.7e-46 316275003649 Similar to Escherichia coli Inner membrane transport protein YhaO UniProt:P42628 (443 aa) fasta scores: E()=2e-81, 63.537% id in 458 aa. CDS is disrupted by the insertion of an IS element after codon 370 316275003650 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003652 Predicted helix-turn-helix motif with score 1048.000, SD 2.76 at aa 288-309, sequence ISQEQAAEAMNKNISALAIIAH 316275003653 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275003654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275003655 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275003656 S-formylglutathione hydrolase; Region: PLN02442 316275003657 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 316275003658 HMMPfam hit to PF00756, esterase, score 5.7e-82 316275003659 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 316275003660 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 316275003661 substrate binding site [chemical binding]; other site 316275003662 catalytic Zn binding site [ion binding]; other site 316275003663 NAD binding site [chemical binding]; other site 316275003664 structural Zn binding site [ion binding]; other site 316275003665 dimer interface [polypeptide binding]; other site 316275003666 HMMPfam hit to PF00107, Zinc-binding dehydrogenase,score 2.6e-40 316275003667 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 4.5e-37 316275003668 PS00059 Zinc-containing alcohol dehydrogenases signature. 316275003669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275003670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275003671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275003672 dimerization interface [polypeptide binding]; other site 316275003673 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.7e-15 316275003674 Predicted helix-turn-helix motif with score 1285.000, SD 3.56 at aa 17-38, sequence QSFTGAAKALDTSVAQISRKVA 316275003675 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.4e-46 316275003676 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 316275003677 nucleoside/Zn binding site; other site 316275003678 dimer interface [polypeptide binding]; other site 316275003679 catalytic motif [active] 316275003680 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1.6e-41 316275003681 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 316275003682 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 316275003683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275003684 substrate binding pocket [chemical binding]; other site 316275003685 membrane-bound complex binding site; other site 316275003686 hinge residues; other site 316275003687 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275003688 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275003689 catalytic residue [active] 316275003690 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 2.9e-32 316275003691 PS00922 Prokaryotic transglycosylases signature. 316275003692 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.1e-26 316275003693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003694 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 316275003695 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 316275003696 dimerization interface [polypeptide binding]; other site 316275003697 ATP binding site [chemical binding]; other site 316275003698 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 316275003699 dimerization interface [polypeptide binding]; other site 316275003700 ATP binding site [chemical binding]; other site 316275003701 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 316275003702 putative active site [active] 316275003703 catalytic triad [active] 316275003704 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 5.4e-35 316275003705 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 5.1e-37 316275003706 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 4.6e-19 316275003707 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 316275003708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 316275003710 HMMPfam hit to PF04400, Protein of unknown function (DUF539), score 2e-11 316275003711 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 316275003712 DNA binding residues [nucleotide binding] 316275003713 HMMPfam hit to PF02001, Protein of unknown function DUF134, score 2.8e-13 316275003714 HMMPfam hit to PF08281, Sigma-70, region, score 0.0025 316275003715 Predicted helix-turn-helix motif with score 1739.000, SD 5.11 at aa 50-71, sequence LNQQACADQMGISRQTFGNTIK 316275003716 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 316275003717 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 5.1e-20 316275003718 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 316275003720 Protein of unknown function (DUF3622); Region: DUF3622; pfam12286 316275003721 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 316275003722 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 316275003723 aromatic chitin/cellulose binding site residues [chemical binding]; other site 316275003724 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 316275003725 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 316275003726 putative active site [active] 316275003727 HMMPfam hit to PF00704, Glycosyl hydrolases family,score 1.4e-23 316275003728 PS01095 Chitinases family 18 active site. 316275003729 HMMPfam hit to PF02839, Carbohydrate binding domain, score 0.0065 316275003730 HMMPfam hit to PF02839, Carbohydrate binding domain, score 1.6e-06 316275003731 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 316275003732 Predicted deacylase [General function prediction only]; Region: COG3608 316275003733 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 316275003734 putative active site [active] 316275003735 Zn binding site [ion binding]; other site 316275003736 HMMPfam hit to PF04952, Succinylglutamate desuccinylase / Aspartoac, score 9.8e-87 316275003737 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 316275003738 RimK-like ATP-grasp domain; Region: RimK; pfam08443 316275003739 HMMPfam hit to PF08443, RimK-like ATP-grasp domain,score 9.3e-90 316275003740 HMMPfam hit to PF02955, Prokaryotic glutathione synthetase, ATP-g, score 1.1e-10 316275003741 HMMPfam hit to PF02655, ATP-grasp domain, score 0.00014 316275003742 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 316275003743 HMMPfam hit to PF05618, Protein of unknown function (DUF785), score 1.9e-55 316275003744 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 316275003745 Na2 binding site [ion binding]; other site 316275003746 putative substrate binding site 1 [chemical binding]; other site 316275003747 Na binding site 1 [ion binding]; other site 316275003748 putative substrate binding site 2 [chemical binding]; other site 316275003749 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 1.2e-10 316275003751 Similar to Vibrio harveyi chitinase A ChiA UniProt:P96168 (729 aa) fasta scores: E()=1.1e-29, 40.099% id in 202 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275003752 HMMPfam hit to PF02839, Carbohydrate binding domain, score 0.0088 316275003753 HMMPfam hit to PF02839, Carbohydrate binding domain, score 0.00096 316275003754 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=2.1e-119, 56.795% id in 493 aa. CDS contains frameshifts after codon 399 adn 418 316275003755 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase (is66 family element,orf2-like). UniProt:Q3IIG1 (EMBL:CR954246) (115 aa) fasta scores: E()=6.3e-31,58.261% id in 115 aa. CDS contains a translational stopcodon after codon 34 316275003756 Weakly similar to Bacteriophage Mu Protein gp38 UniProt:P79677 (67 aa) fasta scores: E()=0.0037, 47.826% id in 46 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275003757 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 316275003758 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 316275003759 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 316275003760 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 316275003761 HMMPfam hit to PF05125, Phage major capsid protein,P2 family, score 8.2e-85 316275003762 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003763 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 316275003764 terminase ATPase subunit; Provisional; Region: P; PHA02535 316275003765 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 316275003766 Predicted helix-turn-helix motif with score 1994.000, SD 5.98 at aa 39-60, sequence YETKEIAEETNVNPRTVQQWIA 316275003767 HMMPfam hit to PF03237, Terminase-like family,score 4.9e-81 316275003768 Similar to Bacteriophage P2 Presumed portal vertex protein (GpQ) UniProt:P25480 (344 aa) fasta scores: E()=6.2e-09, 40.769% id in 130 aa. CDS contains a frameshift after codon 190. The sequence has been checked and is believed to be correct 316275003769 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316275003770 putative active site [active] 316275003771 HMMPfam hit to PF02698, DUF218 domain, score 1.5e-14 316275003772 Similar to Vibrio fischeri Thioredoxin peroxidase UniProt:Q5E1J4 (177 aa) fasta scores: E()=5.7e-32, 60.544% id in 147 aa. The CDS appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275003773 HMMPfam hit to PF08534, Redoxin, score 0.00085 316275003774 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 316275003775 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316275003776 amidase catalytic site [active] 316275003777 Zn binding residues [ion binding]; other site 316275003778 substrate binding site [chemical binding]; other site 316275003779 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316275003780 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 1.2e-43 316275003781 PS00018 EF-hand calcium-binding domain. 316275003783 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 316275003785 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275003786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275003787 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275003788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275003789 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275003790 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275003791 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275003792 GTP-binding protein YchF; Reviewed; Region: PRK09601 316275003793 YchF GTPase; Region: YchF; cd01900 316275003794 G1 box; other site 316275003795 GTP/Mg2+ binding site [chemical binding]; other site 316275003796 Switch I region; other site 316275003797 G2 box; other site 316275003798 Switch II region; other site 316275003799 G3 box; other site 316275003800 G4 box; other site 316275003801 G5 box; other site 316275003802 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 316275003803 HMMPfam hit to PF01926, GTPase of unknown function,score 9.9e-29 316275003804 PS00017 ATP/GTP-binding site motif A (P-loop). 316275003805 PS00443 Glutamine amidotransferases class-II active site. 316275003806 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 316275003807 putative active site [active] 316275003808 catalytic residue [active] 316275003809 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase,score 3.6e-59 316275003810 PS01196 Peptidyl-tRNA hydrolase signature 2. 316275003811 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 316275003812 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 316275003813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316275003814 active site 316275003815 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 2e-34 316275003816 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 316275003817 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 316275003818 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 316275003819 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 316275003820 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 316275003821 HMMPfam hit to PF08544, GHMP kinases C terminal,score 0.0024 316275003822 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 3.7e-16 316275003823 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 316275003824 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 316275003825 HMMPfam hit to PF03550, Outer membrane lipoprotein LolB, score 3.1e-50 316275003827 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003828 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 316275003829 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 316275003830 tRNA; other site 316275003831 putative tRNA binding site [nucleotide binding]; other site 316275003832 putative NADP binding site [chemical binding]; other site 316275003833 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 316275003834 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase,N-terminal d, score 2.6e-71 316275003835 PS00747 Glutamyl-tRNA reductase signature. 316275003836 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 7.3e-71 316275003837 HMMPfam hit to PF00745, Glutamyl-tRNAGlu reductase,dimerisation, score 1.6e-29 316275003838 peptide chain release factor 1; Validated; Region: prfA; PRK00591 316275003839 This domain is found in peptide chain release factors; Region: PCRF; smart00937 316275003840 RF-1 domain; Region: RF-1; pfam00472 316275003841 HMMPfam hit to PF03462, PCRF domain, score 1e-67 316275003842 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 3.3e-71 316275003843 PS00745 Prokaryotic-type class I peptide chain release factors signature. 316275003844 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 316275003845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275003846 HMMPfam hit to PF05175, Methyltransferase small domain, score 5.9e-08 316275003847 PS00092 N-6 Adenine-specific DNA methylases signature. 316275003848 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 316275003849 HMMPfam hit to PF04247, Invasion gene expression up-regulator, SirB, score 6.4e-45 316275003851 hypothetical protein; Provisional; Region: PRK10941 316275003852 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 316275003853 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 316275003854 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 316275003855 HMMPfam hit to PF00793, DAHP synthetase I family,score 9.8e-117 316275003856 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 316275003857 diphthine synthase; Region: dph5; TIGR00522 316275003858 active site 316275003859 SAM binding site [chemical binding]; other site 316275003860 homodimer interface [polypeptide binding]; other site 316275003861 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 4.6e-79 316275003862 PS00840 Uroporphyrin-III C-methyltransferase signature 2. 316275003863 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 316275003864 HMMPfam hit to PF01226, Formate/nitrite transporter score 8.8e-25 316275003866 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 316275003867 nitrite reductase subunit NirD; Provisional; Region: PRK14989 316275003868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275003869 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316275003870 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316275003871 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316275003872 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 2.2e-44 316275003873 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 316275003874 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 1.4e-19 316275003875 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 2.3e-22 316275003876 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoredu, score 5.7e-47 316275003877 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 1.2e-20 316275003878 Cache domain; Region: Cache_1; pfam02743 316275003879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275003880 dimerization interface [polypeptide binding]; other site 316275003881 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275003882 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275003883 dimer interface [polypeptide binding]; other site 316275003884 putative CheW interface [polypeptide binding]; other site 316275003885 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 6.9e-59 316275003886 HMMPfam hit to PF00672, HAMP domain, score 4.2e-14 316275003888 HMMPfam hit to PF02743, Cache domain, score 4.4e-15 316275003889 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 316275003890 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 316275003891 active site 316275003892 metal binding site [ion binding]; metal-binding site 316275003893 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316275003894 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275003895 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.7e-19 316275003896 PS00785 5'-nucleotidase signature 1. 316275003897 PS00786 5'-nucleotidase signature 2. 316275003898 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 1.1e-47 316275003899 Predicted metal-binding protein [General function prediction only]; Region: COG3019 316275003900 HMMPfam hit to PF04214, Protein of unknown function, DUF, score 1.4e-53 316275003901 Heavy-metal-associated domain; Region: HMA; pfam00403 316275003902 metal-binding site [ion binding] 316275003903 copper exporting ATPase; Provisional; Region: copA; PRK10671 316275003904 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316275003905 metal-binding site [ion binding] 316275003906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316275003907 Soluble P-type ATPase [General function prediction only]; Region: COG4087 316275003909 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.8e-30 316275003910 PS01229 Hypothetical cof family signature 2. 316275003911 PS00154 E1-E2 ATPases phosphorylation site. 316275003912 HMMPfam hit to PF00122, E1-E2 ATPase, score 6.2e-94 316275003913 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 2.9e-12 316275003914 PS01047 Heavy-metal-associated domain. 316275003915 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 0.0019 316275003916 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 316275003917 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 316275003918 DNA binding residues [nucleotide binding] 316275003919 dimer interface [polypeptide binding]; other site 316275003920 copper binding site [ion binding]; other site 316275003921 Predicted helix-turn-helix motif with score 1580.000, SD 4.57 at aa 1-22, sequence MNISDVAKLTGLTTKAIRFYES 316275003922 HMMPfam hit to PF00376, MerR family regulatory protein, score 2e-11 316275003923 PS00552 Bacterial regulatory proteins, merR family signature. 316275003924 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 316275003925 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 316275003926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275003927 binding surface 316275003928 TPR motif; other site 316275003929 HMMPfam hit to PF00085, Thioredoxin, score 5.3e-07 316275003930 PS00430 TonB-dependent receptor proteins signature 1. 316275003931 short chain dehydrogenase; Provisional; Region: PRK05993 316275003932 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 316275003933 NADP binding site [chemical binding]; other site 316275003934 active site 316275003935 steroid binding site; other site 316275003936 HMMPfam hit to PF00106, short chain dehydrogenase,score 1.2e-07 316275003937 PS00061 Short-chain dehydrogenases/reductases family signature. 316275003938 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 316275003939 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 316275003940 putative NAD(P) binding site [chemical binding]; other site 316275003941 putative active site [active] 316275003942 HMMPfam hit to PF08338, Domain of unknown function (DUF1731), score 6.2e-22 316275003943 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 1e-08 316275003944 HMMPfam hit to PF07993, Male sterility protein,score 0.0039 316275003945 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 316275003946 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316275003947 active site 316275003948 metal binding site [ion binding]; metal-binding site 316275003949 homotetramer interface [polypeptide binding]; other site 316275003950 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.5e-14 316275003951 HMMPfam hit to PF01609, Transposase DDE domain,score 0.00011 316275003952 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275003953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275003954 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275003955 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275003956 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275003957 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275003958 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275003960 Similar to Vibrio fischeri ToxR protein UniProt:Q56689 (316 aa) fasta scores: E()=2.1e-62, 68.651% id in 252 aa. CDS contains a frameshift after codon 5. The sequence has been checked and is believed to be correct 316275003961 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 2.6e-18 316275003962 heat shock protein 90; Provisional; Region: PRK05218 316275003963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275003964 ATP binding site [chemical binding]; other site 316275003965 Mg2+ binding site [ion binding]; other site 316275003966 G-X-G motif; other site 316275003967 PS00298 Heat shock hsp90 proteins family signature. 316275003968 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2e-09 316275003969 HMMPfam hit to PF00183, Hsp90 protein, score 1.8e-90 316275003970 adenylate kinase; Reviewed; Region: adk; PRK00279 316275003971 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 316275003972 AMP-binding site [chemical binding]; other site 316275003973 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 316275003974 HMMPfam hit to PF00406, Adenylate kinase, score 4.8e-95 316275003975 PS00113 Adenylate kinase signature. 316275003976 HMMPfam hit to PF05191, Adenylate kinase, active site lid, score 5.7e-17 316275003977 ferrochelatase; Reviewed; Region: hemH; PRK00035 316275003978 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 316275003979 C-terminal domain interface [polypeptide binding]; other site 316275003980 active site 316275003981 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 316275003982 active site 316275003983 N-terminal domain interface [polypeptide binding]; other site 316275003984 HMMPfam hit to PF00762, Ferrochelatase, score 1.1e-109 316275003985 PS00534 Ferrochelatase signature. 316275003986 trigger factor; Provisional; Region: tig; PRK01490 316275003987 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316275003988 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 316275003989 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 1.2e-63 316275003990 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomera, score 2.3e-25 316275003991 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 1.5e-54 316275003992 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 316275003993 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 316275003994 oligomer interface [polypeptide binding]; other site 316275003995 active site residues [active] 316275003996 HMMPfam hit to PF00574, Clp protease, score 2.2e-137 316275003997 PS00381 Endopeptidase Clp serine active site. 316275003998 PS00382 Endopeptidase Clp histidine active site. 316275003999 HMMPfam hit to PF06689, ClpX C4-type zinc finger,score 6.9e-26 316275004000 HMMPfam hit to PF07724, ATPase family associated with various cell, score 1e-78 316275004001 HMMPfam hit to PF00004, ATPase family associated with various cell, score 8.1e-06 316275004002 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004003 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275004004 HMMPfam hit to PF01609, Transposase DDE domain,score 2.3e-39 316275004005 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 316275004006 Found in ATP-dependent protease La (LON); Region: LON; smart00464 316275004007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275004008 Walker A motif; other site 316275004009 ATP binding site [chemical binding]; other site 316275004010 Walker B motif; other site 316275004011 arginine finger; other site 316275004012 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316275004013 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 7.1e-52 316275004014 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2e-41 316275004015 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.8e-05 316275004016 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004017 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 1.3e-152 316275004018 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316275004019 IHF dimer interface [polypeptide binding]; other site 316275004020 IHF - DNA interface [nucleotide binding]; other site 316275004021 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.9e-51 316275004022 PS00045 Bacterial histone-like DNA-binding proteins signature. 316275004023 periplasmic folding chaperone; Provisional; Region: PRK10788 316275004024 SurA N-terminal domain; Region: SurA_N_3; cl07813 316275004025 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 316275004027 HMMPfam hit to PF00639, PPIC-type PPIASE domain,score 2.5e-30 316275004028 PS01096 PpiC-type peptidyl-prolyl cis-trans isomerase signature. 316275004029 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 316275004030 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 316275004031 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 316275004032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275004033 putative substrate translocation pore; other site 316275004035 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-17 316275004036 HMMPfam hit to PF00854, POT family, score 4.5e-32 316275004037 PS01023 PTR2 family proton/oligopeptide symporters signature 2. 316275004038 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 316275004039 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 316275004040 HMMPfam hit to PF02357, Transcription termination factor nusG, score 3.7e-27 316275004041 asparagine synthetase B; Provisional; Region: asnB; PRK09431 316275004042 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 316275004043 active site 316275004044 dimer interface [polypeptide binding]; other site 316275004045 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 316275004046 Ligand Binding Site [chemical binding]; other site 316275004047 Molecular Tunnel; other site 316275004048 HMMPfam hit to PF00733, Asparagine synthase, score 8e-104 316275004049 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 1.7e-25 316275004050 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 316275004051 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 316275004052 TrkA-N domain; Region: TrkA_N; pfam02254 316275004053 HMMPfam hit to PF02254, TrkA-N domain, score 4.4e-19 316275004055 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 3.7e-57 316275004056 MarR family; Region: MarR; pfam01047 316275004057 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316275004058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316275004059 nucleotide binding site [chemical binding]; other site 316275004060 HMMPfam hit to PF00480, ROK family, score 1.5e-61 316275004061 PS01125 ROK family signature. 316275004062 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 316275004063 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 316275004064 active site 316275004065 dimer interface [polypeptide binding]; other site 316275004066 HMMPfam hit to PF01979, Amidohydrolase family,score 5.6e-24 316275004067 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 316275004068 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 316275004069 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 316275004070 active site turn [active] 316275004071 phosphorylation site [posttranslational modification] 316275004072 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 9.1e-90 316275004074 HMMPfam hit to PF00367, phosphotransferase system,EIIB, score 4.5e-15 316275004075 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 316275004076 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 316275004077 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316275004078 active site 316275004079 HIGH motif; other site 316275004080 nucleotide binding site [chemical binding]; other site 316275004081 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 316275004082 KMSKS motif; other site 316275004083 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 316275004084 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), ca, score 3.2e-178 316275004085 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275004086 HMMPfam hit to PF03950, tRNA synthetases class I (E and Q), an, score 1.2e-97 316275004087 ferric uptake regulator; Provisional; Region: fur; PRK09462 316275004088 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 316275004089 metal binding site 2 [ion binding]; metal-binding site 316275004090 putative DNA binding helix; other site 316275004091 metal binding site 1 [ion binding]; metal-binding site 316275004092 dimer interface [polypeptide binding]; other site 316275004093 structural Zn2+ binding site [ion binding]; other site 316275004094 HMMPfam hit to PF01475, Ferric uptake regulator family, score 3.4e-69 316275004095 flavodoxin FldA; Validated; Region: PRK09267 316275004096 HMMPfam hit to PF00258, Flavodoxin, score 4.1e-50 316275004097 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 316275004099 acyl-CoA esterase; Provisional; Region: PRK10673 316275004100 PGAP1-like protein; Region: PGAP1; pfam07819 316275004101 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 1.4e-15 316275004102 HMMPfam hit to PF07819, PGAP1-like protein, score 2.7e-11 316275004103 replication initiation regulator SeqA; Provisional; Region: PRK11187 316275004104 HMMPfam hit to PF03925, SeqA protein, score 8.4e-94 316275004105 phosphoglucomutase; Validated; Region: PRK07564 316275004106 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 316275004107 active site 316275004108 substrate binding site [chemical binding]; other site 316275004109 metal binding site [ion binding]; metal-binding site 316275004110 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 4.2e-41 316275004111 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 316275004112 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 8.1e-14 316275004113 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 2.2e-23 316275004114 HMMPfam hit to PF00408,Phosphoglucomutase/phosphomannomutase, C-, score 1.5e-19 316275004115 Uncharacterized conserved protein [Function unknown]; Region: COG0327 316275004116 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 316275004117 HMMPfam hit to PF01784, NIF3 (NGG1p interacting factor 3), score 1.9e-111 316275004118 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 316275004119 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 316275004120 dimer interface [polypeptide binding]; other site 316275004121 active site 316275004122 citrylCoA binding site [chemical binding]; other site 316275004123 NADH binding [chemical binding]; other site 316275004124 cationic pore residues; other site 316275004125 oxalacetate/citrate binding site [chemical binding]; other site 316275004126 coenzyme A binding site [chemical binding]; other site 316275004127 catalytic triad [active] 316275004128 HMMPfam hit to PF00285, Citrate synthase, score 9.9e-229 316275004129 PS00480 Citrate synthase signature. 316275004130 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 316275004131 Iron-sulfur protein interface; other site 316275004132 proximal quinone binding site [chemical binding]; other site 316275004133 SdhD (CybS) interface [polypeptide binding]; other site 316275004134 proximal heme binding site [chemical binding]; other site 316275004135 HMMPfam hit to PF01127, Succinate dehydrogenase cytochrome b subunit, score 1.3e-43 316275004136 PS01000 Succinate dehydrogenase cytochrome b subunit signature 1. 316275004138 PS01001 Succinate dehydrogenase cytochrome b subunit signature 2. 316275004139 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 316275004140 SdhC subunit interface [polypeptide binding]; other site 316275004141 proximal heme binding site [chemical binding]; other site 316275004142 cardiolipin binding site; other site 316275004143 Iron-sulfur protein interface; other site 316275004144 proximal quinone binding site [chemical binding]; other site 316275004146 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 316275004147 L-aspartate oxidase; Provisional; Region: PRK06175 316275004148 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316275004149 HMMPfam hit to PF00890, FAD binding domain, score 3.4e-171 316275004150 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 316275004151 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 2.2e-66 316275004152 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 316275004153 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 316275004154 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275004155 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 316275004156 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 316275004157 TPP-binding site [chemical binding]; other site 316275004158 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 316275004159 dimer interface [polypeptide binding]; other site 316275004160 PYR/PP interface [polypeptide binding]; other site 316275004161 TPP binding site [chemical binding]; other site 316275004162 HMMPfam hit to PF00676, Dehydrogenase E1 component,score 3.2e-39 316275004163 HMMPfam hit to PF02779, Transketolase, pyridine binding domain, score 5.6e-72 316275004164 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 316275004165 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 316275004166 E3 interaction surface; other site 316275004167 lipoyl attachment site [posttranslational modification]; other site 316275004168 e3 binding domain; Region: E3_binding; pfam02817 316275004169 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 316275004170 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 3.2e-25 316275004171 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 316275004172 HMMPfam hit to PF02817, e3 binding domain, score 2.3e-17 316275004173 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 3e-142 316275004174 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 316275004175 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 316275004176 CoA-ligase; Region: Ligase_CoA; pfam00549 316275004177 HMMPfam hit to PF08442, ATP-grasp domain, score 5e-116 316275004178 HMMPfam hit to PF00549, CoA-ligase, score 6.3e-80 316275004179 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 316275004180 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 316275004181 CoA binding domain; Region: CoA_binding; smart00881 316275004182 CoA-ligase; Region: Ligase_CoA; pfam00549 316275004183 HMMPfam hit to PF02629, CoA binding domain, score 1e-50 316275004184 HMMPfam hit to PF00549, CoA-ligase, score 8.2e-69 316275004185 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 316275004186 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 316275004187 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316275004188 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275004189 dimer interface [polypeptide binding]; other site 316275004190 putative PBP binding regions; other site 316275004191 ABC-ATPase subunit interface; other site 316275004192 HMMPfam hit to PF00950, ABC 3 transport family,score 5.7e-93 316275004194 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 316275004195 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316275004196 HMMPfam hit to PF00005, ABC transporter score 1.8e-51 316275004197 PS00211 ABC transporters family signature. 316275004198 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004199 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 316275004200 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 316275004201 metal binding site [ion binding]; metal-binding site 316275004202 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 8.9e-30 316275004203 putative peptidase; Provisional; Region: PRK11649 316275004204 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 316275004205 Peptidase family M23; Region: Peptidase_M23; pfam01551 316275004207 HMMPfam hit to PF04225, Opacity-associated protein A LysM-like, score 4.3e-05 316275004208 HMMPfam hit to PF01551, Peptidase family M23, score 1.6e-49 316275004209 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 316275004210 metal binding triad [ion binding]; metal-binding site 316275004211 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 316275004212 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 316275004213 active site 316275004214 HIGH motif; other site 316275004215 dimer interface [polypeptide binding]; other site 316275004216 KMSKS motif; other site 316275004217 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275004218 RNA binding surface [nucleotide binding]; other site 316275004219 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 6.5e-116 316275004220 HMMPfam hit to PF01479, S4 domain, score 8.4e-06 316275004221 hypothetical protein; Provisional; Region: PRK01254 316275004222 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 316275004223 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 316275004224 HMMPfam hit to PF04055, Radical SAM superfamily,score 1.3e-07 316275004225 PS01278 Uncharacterized protein family UPF0004 signature. 316275004226 HMMPfam hit to PF08497, Radical SAM N-terminal,score 1.2e-259 316275004227 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 316275004228 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 316275004230 HMMPfam hit to PF06808, DctM-like transporters,score 0.00091 316275004231 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 3.8e-189 316275004232 HMMPfam hit to PF03600, Citrate transporter score 0.0023 316275004234 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 316275004235 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 316275004236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275004237 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 316275004238 putative dimerization interface [polypeptide binding]; other site 316275004239 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.7e-41 316275004240 PS00300 SRP54-type proteins GTP-binding domain signature. 316275004241 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.6e-17 316275004242 PS00044 Bacterial regulatory proteins, lysR family signature. 316275004243 Predicted helix-turn-helix motif with score 1892.000, SD 5.63 at aa 17-38, sequence GSLTATANALHLTQSALSHQLK 316275004244 Similar to Escherichia coli 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE UniProt:P25665 (752 aa) fasta scores: E()=1.1e-20, 61.702% id in 94 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275004245 HMMPfam hit to PF08267, Cobalamin-independent synthase, N-termina, score 1.6e-07 316275004246 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275004247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275004248 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275004249 Similar to Vibrio cholerae Accessory colonization factor AcfD precursor UniProt:Q9KTQ4 (1520 aa) fasta scores: E()=5.8e-72, 35.620% id in 1283 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275004250 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004251 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 316275004252 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 316275004253 dimer interface [polypeptide binding]; other site 316275004254 active site 316275004255 glycine-pyridoxal phosphate binding site [chemical binding]; other site 316275004256 folate binding site [chemical binding]; other site 316275004257 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase,major doma, score 0.065 316275004258 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 2.3e-269 316275004259 HMMPfam hit to PF01212, Beta-eliminating lyase,score 0.0018 316275004260 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 316275004261 Uncharacterized conserved protein [Function unknown]; Region: COG1284 316275004262 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 316275004263 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 8.6e-18 316275004265 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 2.2e-19 316275004266 Predicted periplasmic protein [General function prediction only]; Region: COG3895 316275004267 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 316275004268 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004269 Similar to Bacillus subtilis Oligopeptide transport ATP-binding protein AppF UniProt:P42065 (329 aa) fasta scores: E()=8.7e-39, 58.095% id in 210 aa. CDS contains a nonsense mutation (TCG to TAG) after codon 102. The sequence has been checked and is believed to be correct 316275004270 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter C-termi, score 8.1e-35 316275004271 HMMPfam hit to PF00005, ABC transporter score 1.2e-13 316275004272 PS00211 ABC transporters family signature. 316275004273 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004274 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316275004275 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316275004276 Walker A/P-loop; other site 316275004277 ATP binding site [chemical binding]; other site 316275004278 Q-loop/lid; other site 316275004279 ABC transporter signature motif; other site 316275004280 Walker B; other site 316275004281 D-loop; other site 316275004282 H-loop/switch region; other site 316275004283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316275004284 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter C-termi, score 6e-30 316275004285 HMMPfam hit to PF00005, ABC transporter score 7.4e-62 316275004286 PS00211 ABC transporters family signature. 316275004287 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004288 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 316275004289 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 316275004290 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 4.5e-51 316275004292 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 316275004293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275004294 dimer interface [polypeptide binding]; other site 316275004295 conserved gate region; other site 316275004296 putative PBP binding loops; other site 316275004297 ABC-ATPase subunit interface; other site 316275004298 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 7.2e-44 316275004300 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 316275004301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275004302 dimer interface [polypeptide binding]; other site 316275004303 conserved gate region; other site 316275004304 putative PBP binding loops; other site 316275004305 ABC-ATPase subunit interface; other site 316275004306 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.7e-43 316275004308 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275004309 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 316275004310 BCCT family transporter; Region: BCCT; pfam02028 316275004311 HMMPfam hit to PF02028, BCCT family transporterscore 1.8e-59 316275004313 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 316275004314 Membrane dipeptidase (Peptidase family M19); Region: Peptidase_M19; pfam01244 316275004315 active site 316275004316 HMMPfam hit to PF01244, Membrane dipeptidase (Peptidase family, score 1.7e-103 316275004317 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 316275004318 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 316275004319 NAD(P) binding site [chemical binding]; other site 316275004320 catalytic residues [active] 316275004321 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 2.7e-183 316275004322 PS00070 Aldehyde dehydrogenases cysteine active site. 316275004323 Predicted helix-turn-helix motif with score 1104.000, SD 2.95 at aa 40-61, sequence EWQSGISTIANINPSDISQHLG 316275004324 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 316275004325 homotrimer interaction site [polypeptide binding]; other site 316275004326 putative active site [active] 316275004327 HMMPfam hit to PF01042, Endoribonuclease L-PSP,score 2.1e-25 316275004328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275004329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275004330 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 316275004331 putative dimerization interface [polypeptide binding]; other site 316275004332 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.1e-13 316275004333 PS00044 Bacterial regulatory proteins, lysR family signature. 316275004334 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.1e-37 316275004335 virulence protein SpvB; Provisional; Region: PRK15244 316275004336 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 316275004337 active site 316275004338 conformational flexibility of ligand binding pocket; other site 316275004340 PS00334 Myb DNA-binding domain repeat signature 2. 316275004342 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 316275004343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275004344 active site 316275004345 motif I; other site 316275004346 motif II; other site 316275004347 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 316275004348 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 316275004349 Walker A/P-loop; other site 316275004350 ATP binding site [chemical binding]; other site 316275004351 Q-loop/lid; other site 316275004352 ABC transporter signature motif; other site 316275004353 Walker B; other site 316275004354 D-loop; other site 316275004355 H-loop/switch region; other site 316275004356 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 316275004357 HMMPfam hit to PF00005, ABC transporter score 3.7e-71 316275004358 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004359 PS00211 ABC transporters family signature. 316275004360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275004361 dimer interface [polypeptide binding]; other site 316275004362 conserved gate region; other site 316275004363 ABC-ATPase subunit interface; other site 316275004364 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.5e-20 316275004366 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275004367 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 316275004368 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 316275004369 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004370 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.1e-137 316275004371 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 316275004372 HMMPfam hit to PF00444, Ribosomal protein L36,score 4.3e-06 316275004373 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 316275004374 HMMPfam hit to PF01197, Ribosomal protein L31,score 5.2e-18 316275004375 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 316275004376 homodimer interaction site [polypeptide binding]; other site 316275004377 cofactor binding site; other site 316275004378 HMMPfam hit to PF01980, Uncharacterised protein family UPF0066, score 1.8e-49 316275004379 PS01318 Uncharacterized protein family UPF0066 signature. 316275004380 prolyl-tRNA synthetase; Provisional; Region: PRK09194 316275004381 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 316275004382 dimer interface [polypeptide binding]; other site 316275004383 motif 1; other site 316275004384 active site 316275004385 motif 2; other site 316275004386 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 316275004387 putative deacylase active site [active] 316275004388 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316275004389 active site 316275004390 motif 3; other site 316275004391 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 316275004392 anticodon binding site; other site 316275004393 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 7.3e-55 316275004394 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275004395 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 5.3e-07 316275004396 HMMPfam hit to PF03129, Anticodon binding domain,score 1e-23 316275004397 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 316275004398 HMMPfam hit to PF04074, Domain of unknown function (DUF386), score 4.2e-57 316275004399 Similar to Vibrio fischeri Sodium-glucose/galactose cotransporter UniProt:Q5E733 (505 aa) fasta scores: E()=8.5e-163, 93.159% id in 497 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275004401 HMMPfam hit to PF00474, Sodium:solute symporter family, score 4.3e-10 316275004402 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275004403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275004404 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=6.6e-110, 56.2% id in 493 aa overlap. CDS contains a frameshift after codon 70 316275004405 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 316275004406 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 316275004407 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 316275004408 putative active site [active] 316275004409 HMMPfam hit to PF01380, SIS domain, score 2.1e-19 316275004410 HMMPfam hit to PF01418, Helix-turn-helix domain,rpiR family, score 7.2e-26 316275004411 Predicted helix-turn-helix motif with score 984.000, SD 2.54 at aa 45-66, sequence HSIAELSQIVNAGDATIIRFCR 316275004412 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 316275004413 Class I aldolases; Region: Aldolase_Class_I; cl17187 316275004414 catalytic residue [active] 316275004415 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 7.6e-33 316275004416 PS00665 Dihydrodipicolinate synthetase signature 1. 316275004417 hypothetical protein; Provisional; Region: PRK04964 316275004418 HMMPfam hit to PF06786, Uncharacterised protein family (UPF0253), score 1.5e-38 316275004419 Domain of unknown function (DUF4250); Region: DUF4250; pfam14056 316275004420 Similar to Vibrio harveyi Chitinase A ChiA UniProt:P96168 (729 aa) fasta scores: E()=4.7e-136,67.232% id in 531 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275004421 HMMPfam hit to PF00704, Glycosyl hydrolases family,score 1.3e-19 316275004422 PS01095 Chitinases family 18 active site. 316275004423 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 316275004424 HMMPfam hit to PF07523, no description, score 0.012 316275004425 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275004426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275004427 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=5.8e-104, 51.6% id in 502 aa. CDS is disrupted by stop codons after codon 150 (TAA) and codon 161 (TAA) 316275004428 Similar to Escherichia coli Long-chain-fatty-acid--CoA ligase FadD UniProt:P69451 (561 aa) fasta scores: E()=9.5e-138, 74.180% id in 488 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275004429 HMMPfam hit to PF00501, AMP-binding enzyme, score 3.1e-128 316275004430 PS00455 AMP-binding domain signature. 316275004431 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 316275004432 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 316275004433 PGAP1-like protein; Region: PGAP1; pfam07819 316275004434 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 316275004435 catalytic site [active] 316275004436 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 1e-15 316275004437 HMMPfam hit to PF07819, PGAP1-like protein, score 0.00093 316275004438 PS00120 Lipases, serine active site. 316275004439 Outer membrane lipoprotein Slp family; Region: Slp; pfam03843 316275004440 HMMPfam hit to PF03843, Outer membrane lipoprotein Slp family, score 2.8e-45 316275004441 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004442 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 316275004443 Glycoprotease family; Region: Peptidase_M22; pfam00814 316275004444 HMMPfam hit to PF00814, Glycoprotease family, score 2.2e-54 316275004445 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 316275004446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 316275004447 DEAD_2; Region: DEAD_2; pfam06733 316275004448 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 316275004449 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004450 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 316275004451 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 316275004452 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 316275004453 putative active site [active] 316275004454 putative substrate binding site [chemical binding]; other site 316275004455 putative cosubstrate binding site; other site 316275004456 catalytic site [active] 316275004457 HMMPfam hit to PF01842, ACT domain, score 0.00082 316275004458 HMMPfam hit to PF00551, Formyl transferase, score 8.5e-57 316275004459 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316275004460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316275004461 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 1.4e-08 316275004462 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 316275004463 HMMPfam hit to PF01679, Uncharacterized protein family UPF0057, score 5.1e-21 316275004465 Similar to Vibrio harveyi 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE UniProt:Q8KRG6 (760 aa) fasta scores: E()=5.1e-42, 86.667% id in 135 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275004466 HMMPfam hit to PF01717, Cobalamin-independent synthase, Catalytic, score 1.7e-06 316275004467 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275004468 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275004469 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275004470 Similar to Vibrio cholerae Accessory colonization factor AcfD precursor UniProt:Q9KTQ4 (1520 aa) fasta scores: E()=2.9e-47, 44.558% id in 294 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275004471 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275004472 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 316275004473 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004474 Nitrate and nitrite sensing; Region: NIT; pfam08376 316275004475 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275004476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275004477 dimer interface [polypeptide binding]; other site 316275004478 putative CheW interface [polypeptide binding]; other site 316275004479 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.7e-40 316275004481 HMMPfam hit to PF08376, Nitrate and nitrite sensing, score 2.4e-60 316275004482 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 316275004483 ATP cone domain; Region: ATP-cone; pfam03477 316275004484 HMMPfam hit to PF03477, ATP cone domain, score 5.4e-32 316275004485 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 316275004486 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 316275004487 catalytic motif [active] 316275004488 Zn binding site [ion binding]; other site 316275004489 RibD C-terminal domain; Region: RibD_C; cl17279 316275004490 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1.6e-41 316275004491 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 316275004492 HMMPfam hit to PF01872, RibD C-terminal domain,score 3.9e-53 316275004493 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004494 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 316275004495 Lumazine binding domain; Region: Lum_binding; pfam00677 316275004496 Lumazine binding domain; Region: Lum_binding; pfam00677 316275004497 HMMPfam hit to PF00677, Lumazine binding domain,score 8.4e-34 316275004498 PS00693 Riboflavin synthase alpha chain family signature. 316275004499 HMMPfam hit to PF00677, Lumazine binding domain,score 8.3e-40 316275004500 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 316275004501 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 316275004502 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 316275004503 dimerization interface [polypeptide binding]; other site 316275004504 active site 316275004505 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate, score 1.5e-126 316275004506 HMMPfam hit to PF00925, GTP cyclohydrolase II,score 4.6e-11 316275004507 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 316275004508 homopentamer interface [polypeptide binding]; other site 316275004509 active site 316275004510 HMMPfam hit to PF00885,6,7-dimethyl-8-ribityllumazine synthase, score 5.3e-88 316275004511 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 316275004512 putative RNA binding site [nucleotide binding]; other site 316275004513 HMMPfam hit to PF01029, NusB family, score 2e-40 316275004514 thiamine monophosphate kinase; Provisional; Region: PRK05731 316275004515 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 316275004516 ATP binding site [chemical binding]; other site 316275004517 dimerization interface [polypeptide binding]; other site 316275004518 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 0.00078 316275004519 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 316275004520 tetramer interfaces [polypeptide binding]; other site 316275004521 binuclear metal-binding site [ion binding]; other site 316275004522 HMMPfam hit to PF04608,Phosphatidylglycerophosphatase A, score 7.6e-82 316275004524 Similar to Vibrio harveyi Autoinducer 2-binding periplasmic protein LuxP precursor UniProt:P54300 (365 aa) fasta scores: E()=2e-68, 56.973% id in 337 aa. CDS contains a frameshift after codon 159. The CDS also seems to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275004525 LuxQ, periplasmic; Region: LuxQ-periplasm; pfam09308 316275004526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275004527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275004528 dimer interface [polypeptide binding]; other site 316275004529 phosphorylation site [posttranslational modification] 316275004530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275004531 ATP binding site [chemical binding]; other site 316275004532 Mg2+ binding site [ion binding]; other site 316275004533 G-X-G motif; other site 316275004534 Response regulator receiver domain; Region: Response_reg; pfam00072 316275004535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275004536 active site 316275004537 phosphorylation site [posttranslational modification] 316275004538 intermolecular recognition site; other site 316275004539 dimerization interface [polypeptide binding]; other site 316275004541 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.5e-21 316275004542 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1e-37 316275004543 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.1e-29 316275004544 Uncharacterized conserved protein [Function unknown]; Region: COG1359 316275004545 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 0.0021 316275004546 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 316275004547 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 316275004548 TPP-binding site; other site 316275004549 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316275004550 PYR/PP interface [polypeptide binding]; other site 316275004551 dimer interface [polypeptide binding]; other site 316275004552 TPP binding site [chemical binding]; other site 316275004553 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316275004554 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 3.8e-30 316275004555 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 4.6e-55 316275004556 PS00802 Transketolase signature 2. 316275004557 PS00801 Transketolase signature 1. 316275004558 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 316275004559 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 316275004560 substrate binding pocket [chemical binding]; other site 316275004561 chain length determination region; other site 316275004562 substrate-Mg2+ binding site; other site 316275004563 catalytic residues [active] 316275004564 aspartate-rich region 1; other site 316275004565 active site lid residues [active] 316275004566 aspartate-rich region 2; other site 316275004567 HMMPfam hit to PF00348, Polyprenyl synthetase,score 1.3e-98 316275004568 PS00444 Polyprenyl synthetases signature 2. 316275004569 PS00723 Polyprenyl synthetases signature 1. 316275004570 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 316275004571 HMMPfam hit to PF02609, Exonuclease VII small subunit, score 2.5e-27 316275004572 flagellar motor protein PomA; Reviewed; Region: PRK08990 316275004573 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 316275004575 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 5.5e-07 316275004576 PS01307 Flagellar motor protein motA family signature. 316275004577 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 316275004578 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 316275004579 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275004580 ligand binding site [chemical binding]; other site 316275004582 HMMPfam hit to PF00691, OmpA family, score 1.2e-25 316275004583 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 316275004584 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 316275004585 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 316275004586 Ligand Binding Site [chemical binding]; other site 316275004587 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316275004588 active site residue [active] 316275004589 HMMPfam hit to PF02926, THUMP domain, score 5.5e-24 316275004590 HMMPfam hit to PF02568, Thiamine biosynthesis protein (ThiI), score 1.1e-86 316275004591 HMMPfam hit to PF06508, ExsB, score 0.0021 316275004592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275004593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275004594 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275004595 putative effector binding pocket; other site 316275004596 dimerization interface [polypeptide binding]; other site 316275004597 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.5e-36 316275004598 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1e-16 316275004599 PS00044 Bacterial regulatory proteins, lysR family signature. 316275004600 Predicted helix-turn-helix motif with score 1593.000, SD 4.61 at aa 23-44, sequence GSFSKAAIILDMTPSGVSRQVS 316275004601 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275004602 EamA-like transporter family; Region: EamA; pfam00892 316275004603 EamA-like transporter family; Region: EamA; pfam00892 316275004605 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.8e-17 316275004606 HMMPfam hit to PF03151, Triose-phosphate Transporter family, score 0.0036 316275004607 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1e-20 316275004608 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 316275004609 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 316275004610 conserved cys residue [active] 316275004611 HMMPfam hit to PF01965, DJ-1/PfpI family, score 1.5e-31 316275004612 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 316275004613 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 316275004614 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 316275004615 HMMPfam hit to PF08546, Ketopantoate reductase PanE/ApbA C ter, score 1.5e-46 316275004616 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 2.1e-41 316275004617 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 0.00066 316275004618 Similar to Vibrio alginolyticus Outer membrane protein OmpK UniProt:Q4PNS4 (281 aa) fasta scores: E()=8.6e-71, 72.245% id in 245 aa. CDS contains a nonsense mutation (CAG to TAG) after codon 36. The sequence has been checked and is believed to be correct 316275004619 HMMPfam hit to PF03502, Nucleoside-specific channel-forming prote, score 2.1e-67 316275004620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275004621 muropeptide transporter; Reviewed; Region: ampG; PRK11902 316275004622 putative substrate translocation pore; other site 316275004624 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1e-17 316275004625 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 316275004626 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 316275004627 active site 316275004628 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 1.6e-37 316275004629 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 316275004630 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 316275004631 HMMPfam hit to PF03923, Uncharacterized lipoprotein, score 4.4e-54 316275004632 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004633 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 316275004634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275004635 S-adenosylmethionine binding site [chemical binding]; other site 316275004636 HMMPfam hit to PF05175, Methyltransferase small domain, score 1.5e-65 316275004637 PS00092 N-6 Adenine-specific DNA methylases signature. 316275004638 BolA-like protein; Region: BolA; cl00386 316275004639 HMMPfam hit to PF01722, BolA-like protein, score 1.3e-39 316275004640 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 316275004641 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 316275004642 HMMPfam hit to PF05896, Na(+)-translocating NADH-quinone reductase s, score 3.8e-284 316275004643 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 316275004644 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family,score 4.9e-216 316275004646 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 316275004647 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 316275004649 HMMPfam hit to PF04205, FMN-binding domain, score 1.8e-27 316275004650 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 316275004651 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 1.7e-92 316275004653 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 316275004654 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 6.3e-115 316275004656 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 316275004657 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316275004658 catalytic loop [active] 316275004659 iron binding site [ion binding]; other site 316275004660 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 316275004661 FAD binding pocket [chemical binding]; other site 316275004662 FAD binding motif [chemical binding]; other site 316275004663 phosphate binding motif [ion binding]; other site 316275004664 beta-alpha-beta structure motif; other site 316275004665 NAD binding pocket [chemical binding]; other site 316275004667 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 8.3e-13 316275004668 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 0.00012 316275004669 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 8.6e-18 316275004670 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 316275004671 ApbE family; Region: ApbE; pfam02424 316275004672 HMMPfam hit to PF02424, ApbE family, score 7.8e-108 316275004673 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 316275004676 HMMPfam hit to PF04400, Protein of unknown function (DUF539), score 7.4e-24 316275004677 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 316275004678 active site 316275004679 DNA polymerase IV; Validated; Region: PRK02406 316275004680 DNA binding site [nucleotide binding] 316275004681 HMMPfam hit to PF00817, impB/mucB/samB family,score 8.4e-90 316275004682 Similar to Neisseria gonorrhoeae Hypothetical protein UniProt:Q5F7I0 (539 aa) fasta scores: E()=1.2e-29,53.977% id in 176 aa. The CDS is disrupted by the insertion of an IS element after codon 172 and may be truncated at the N-terminus 316275004683 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275004684 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275004685 HMMPfam hit to PF01609, Transposase DDE domain,score 3.2e-25 316275004686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275004687 non-specific DNA binding site [nucleotide binding]; other site 316275004688 salt bridge; other site 316275004689 sequence-specific DNA binding site [nucleotide binding]; other site 316275004690 HMMPfam hit to PF01381, Helix-turn-helix, score 1.6e-15 316275004691 Predicted helix-turn-helix motif with score 1184.000, SD 3.22 at aa 21-42, sequence VSQDKLALIADIDRSYVGRIER 316275004692 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 316275004693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275004694 ATP binding site [chemical binding]; other site 316275004695 putative Mg++ binding site [ion binding]; other site 316275004696 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 3.2e-08 316275004697 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004698 Uncharacterized conserved protein (DUF2290); Region: DUF2290; cl02396 316275004699 Similar to Agrobacterium tumefaciens (strain C58/ATCC 33970) Hypothetical protein UniProt:Q8UI64 (718 aa) fasta scores: E()=2.2e-102, 41.443% id in 707 aa. CDS contains a frameshift after codon 502. The sequence has been checked and is believed to be correct 316275004700 PS00092 N-6 Adenine-specific DNA methylases signature. 316275004701 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004702 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 316275004703 active site 316275004704 DNA polymerase IV; Validated; Region: PRK02406 316275004705 DNA binding site [nucleotide binding] 316275004706 HMMPfam hit to PF00817, impB/mucB/samB family,score 7.1e-102 316275004707 Predicted helix-turn-helix motif with score 974.000, SD 2.50 at aa 174-195, sequence IEQLELGKISGVGKVTLEKLHK 316275004708 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 316275004709 active site 316275004710 catalytic residues [active] 316275004711 DNA binding site [nucleotide binding] 316275004712 Int/Topo IB signature motif; other site 316275004713 HMMPfam hit to PF00589, Phage integrase family,score 0.02 316275004714 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004715 Similar to C-terminal part of Vibrio fischeri DNA polymerase IV UniProt:Q5E6W7 (365 aa) fasta scores: id E()=1.3e-11, 70.492%; ungapped id 61 aa overlap. The CDS appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275004716 Similar to Mycobacterium tuberculosis alanine racemase Alr UniProt:P0A4X2 (386 aa) fasta scores: E()=2.8e-11, 28.077% id in 260 aa. CDS is disrupted by the insertion of an IS element after codon 98 316275004717 HMMPfam hit to PF01168, Alanine racemase,N-terminal domain, score 4.6e-47 316275004718 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275004719 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275004720 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275004721 HMMPfam hit to PF00842, Alanine racemase,C-terminal domain, score 1.9e-37 316275004722 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 316275004723 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 316275004724 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 316275004725 metal binding site [ion binding]; metal-binding site 316275004726 dimer interface [polypeptide binding]; other site 316275004727 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 5e-10 316275004728 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 1e-16 316275004729 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 316275004730 HMMPfam hit to PF00860, Permease family, score 1.2e-40 316275004732 HMMPfam hit to PF00916, Sulfate transporter family,score 0.00051 316275004733 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316275004734 active site 316275004735 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.3e-14 316275004736 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 316275004737 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 316275004738 HMMPfam hit to PF06500, Alpha/beta hydrolase of unknown function (DU, score 3.1e-230 316275004739 gamma-glutamyl kinase; Provisional; Region: PRK05429 316275004740 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 316275004741 nucleotide binding site [chemical binding]; other site 316275004742 homotetrameric interface [polypeptide binding]; other site 316275004743 putative phosphate binding site [ion binding]; other site 316275004744 putative allosteric binding site; other site 316275004745 PUA domain; Region: PUA; pfam01472 316275004746 HMMPfam hit to PF00696, Amino acid kinase family,score 9.6e-62 316275004747 PS00902 Glutamate 5-kinase signature. 316275004748 HMMPfam hit to PF01472, PUA domain, score 4e-24 316275004749 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 316275004750 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 316275004751 putative catalytic cysteine [active] 316275004752 lipoyl synthase; Provisional; Region: PRK05481 316275004753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275004754 FeS/SAM binding site; other site 316275004755 HMMPfam hit to PF04055, Radical SAM superfamily,score 9.6e-28 316275004756 lipoate-protein ligase B; Provisional; Region: PRK14342 316275004757 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 1.6e-17 316275004758 PS01313 Lipoate-protein ligase B signature. 316275004759 hypothetical protein; Provisional; Region: PRK04998 316275004760 HMMPfam hit to PF04359, Protein of unknown function (DUF493), score 9.2e-48 316275004761 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 316275004762 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 316275004763 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 316275004764 HMMPfam hit to PF07943, Penicillin-binding protein 5, C-termina, score 2.6e-41 316275004765 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 7.5e-124 316275004767 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 316275004768 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 316275004769 Sporulation related domain; Region: SPOR; pfam05036 316275004770 HMMPfam hit to PF05036, Sporulation related domain,score 3.7e-14 316275004771 HMMPfam hit to PF03330, Rare lipoprotein A (RlpA)-like double-psi be, score 1.8e-39 316275004772 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004773 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004774 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 316275004775 HMMPfam hit to PF01098, Cell cycle protein, score 2.1e-148 316275004777 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 316275004778 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004779 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 316275004780 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316275004781 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316275004782 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 7e-89 316275004783 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 5.3e-59 316275004785 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 316275004786 HMMPfam hit to PF02590, Uncharacterized ACR,COG1576, score 1e-82 316275004787 Oligomerisation domain; Region: Oligomerisation; cl00519 316275004788 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 2.2e-40 316275004789 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 316275004790 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 316275004791 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 1.6e-99 316275004792 Lipopolysaccharide-assembly; Region: LptE; cl01125 316275004793 HMMPfam hit to PF04390, Rare lipoprotein B family,score 1.3e-60 316275004795 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275004796 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 316275004797 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 316275004798 HIGH motif; other site 316275004799 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 316275004800 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 316275004801 active site 316275004802 KMSKS motif; other site 316275004803 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 316275004804 tRNA binding surface [nucleotide binding]; other site 316275004805 HMMPfam hit to PF08264, Anticodon-binding domain,score 6.7e-06 316275004806 PS00216 Sugar transport proteins signature 1. 316275004807 HMMPfam hit to PF00133, tRNA synthetases class I (I, L, M and V), score 3.8e-15 316275004808 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275004809 hypothetical protein; Provisional; Region: PRK11032 316275004810 HMMPfam hit to PF07295, Protein of unknown function (DUF1451), score 6.8e-77 316275004811 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 316275004812 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 316275004813 putative active site [active] 316275004814 catalytic triad [active] 316275004815 putative dimer interface [polypeptide binding]; other site 316275004817 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase,score 8.8e-39 316275004818 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 316275004819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316275004820 Transporter associated domain; Region: CorC_HlyC; smart01091 316275004821 HMMPfam hit to PF03471, Transporter associated domain, score 1.4e-25 316275004822 HMMPfam hit to PF00571, CBS domain pair, score 2e-30 316275004823 metal-binding heat shock protein; Provisional; Region: PRK00016 316275004824 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 1.2e-51 316275004825 PS01306 Uncharacterized protein family UPF0054 signature. 316275004826 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 316275004827 PhoH-like protein; Region: PhoH; pfam02562 316275004828 HMMPfam hit to PF02562, PhoH-like protein, score 4.6e-149 316275004829 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004830 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 316275004831 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 316275004832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275004833 FeS/SAM binding site; other site 316275004834 TRAM domain; Region: TRAM; pfam01938 316275004835 HMMPfam hit to PF01938, TRAM domain, score 1.7e-16 316275004836 HMMPfam hit to PF04055, Radical SAM superfamily,score 5e-29 316275004837 PS01278 Uncharacterized protein family UPF0004 signature. 316275004838 HMMPfam hit to PF00919, Uncharacterized protein family UPF0004, score 8.5e-49 316275004839 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 316275004840 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 316275004841 HMMPfam hit to PF01494, FAD binding domain, score 3e-07 316275004843 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275004844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275004845 CDS is disrupted by the insertion of an IS element after codon 379; Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=1.7e-86, 57.6% id in 490 aa. CDS is disrupted by the insertion of an IS element after codon 379 316275004846 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275004847 Putative transposase; Region: Y2_Tnp; pfam04986 316275004848 Similar to N-terminal part of Vibrio fischeri Macrolide-efflux protein UniProt:Q5E486 (622 aa) fasta scores: E()=5.7e-67, 83.673% id in 245 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events. C-terminal part located around 95 kb further downstream 316275004850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275004851 WHG domain; Region: WHG; pfam13305 316275004852 Predicted helix-turn-helix motif with score 1321.000, SD 3.69 at aa 32-53, sequence LSLRKLAKSIGYVPSTLVNIFG 316275004853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 316275004855 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004856 HMMPfam hit to PF04280, Tim44-like domain, score 1.1e-37 316275004857 TIGR02647 family protein; Region: DNA 316275004858 Flagellin N-methylase; Region: FliB; cl00497 316275004859 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 9.5e-14 316275004860 hypothetical protein; Provisional; Region: PRK05170 316275004861 HMMPfam hit to PF05779, Bacterial protein of unknown function (DUF83, score 8.1e-94 316275004862 integrase; Provisional; Region: int; PHA02601 316275004863 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275004864 active site 316275004865 DNA binding site [nucleotide binding] 316275004866 Int/Topo IB signature motif; other site 316275004867 HMMPfam hit to PF00589, Phage integrase family,score 1.3e-24 316275004868 Predicted helix-turn-helix motif with score 978.000, SD 2.52 at aa 252-273, sequence IYKEDSGPLFKIGYSTVYRFIS 316275004870 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 316275004871 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 316275004872 HMMPfam hit to PF07022, Bacteriophage CI repressor helix-turn-h, score 8.4e-11 316275004873 HMMPfam hit to PF07022, Bacteriophage CI repressor helix-turn-h, score 8.1e-14 316275004874 Predicted helix-turn-helix motif with score 1119.000, SD 3.00 at aa 28-49, sequence NSFVELAHLLGIAKGNISTWNS 316275004875 Predicted helix-turn-helix motif with score 1168.000, SD 3.17 at aa 13-34, sequence WTKKKFSEQTGESMSSIENNIK 316275004876 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 316275004877 HMMPfam hit to PF06892, Phage regulatory protein CII (CP76), score 1.8e-66 316275004878 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 316275004879 HMMPfam hit to PF05840, Bacteriophage replication gene A protein (G, score 7.3e-121 316275004881 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 316275004882 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 316275004883 HMMPfam hit to PF04606, Ogr/Delta-like zinc finger,score 0.00031 316275004884 Phage-related protein [Function unknown]; Region: COG4695; cl01923 316275004885 Phage portal protein; Region: Phage_portal; pfam04860 316275004886 HMMPfam hit to PF04860, Phage portal protein, score 4.6e-31 316275004887 terminase ATPase subunit; Provisional; Region: P; PHA02535 316275004888 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 316275004889 HMMPfam hit to PF03237, Terminase-like family,score 1.1e-164 316275004890 HMMPfam hit to PF06056, ATPase subunit of terminase (gpP, score 1.2e-18 316275004891 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 316275004892 HMMPfam hit to PF05929, Phage capsid scaffolding protein (GPO), score 1.5e-24 316275004893 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 316275004894 HMMPfam hit to PF05125, Phage major capsid protein,P2 family, score 2.8e-36 316275004895 terminase endonuclease subunit; Provisional; Region: M; PHA02537 316275004896 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 316275004897 HMMPfam hit to PF05944, Phage small terminase subunit, score 1.5e-16 316275004899 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 316275004900 HMMPfam hit to PF05926, Phage head completion protein (GPL), score 5.5e-35 316275004901 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 316275004902 Similar to Pseudomonas syringae pv. phaseolicola Prophage pspph06, virion morphogenesis protein UniProt:Q48C42 (222 aa) fasta scores: E()=7.8e-11, 42.609% id in 115 aa. CDS contains a frameshift after codon 125. The sequence has been checked and is believed to be correct 316275004903 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 316275004904 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 316275004905 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 316275004906 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 2.4e-06 316275004908 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 316275004909 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 316275004911 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 316275004912 Baseplate J-like protein; Region: Baseplate_J; cl01294 316275004913 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 316275004914 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 316275004915 Predicted helix-turn-helix motif with score 980.000, SD 2.52 at aa 232-253, sequence TSQWQTVFEMKVSKSALSDYVD 316275004916 HMMPfam hit to PF03406, Phage tail fibre repeat,score 0.0011 316275004917 HMMPfam hit to PF03406, Phage tail fibre repeat,score 1.6e-09 316275004918 HMMPfam hit to PF03406, Phage tail fibre repeat,score 0.16 316275004919 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275004920 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275004921 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275004922 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 316275004923 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 316275004924 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 316275004925 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 2.1e-20 316275004926 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316275004927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275004928 Coenzyme A binding pocket [chemical binding]; other site 316275004929 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.3e-18 316275004930 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316275004931 HMMPfam hit to PF01048, Phosphorylase family, score 4.7e-09 316275004932 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 316275004933 active site 316275004934 zinc binding site [ion binding]; other site 316275004935 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 316275004936 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 316275004937 Sulfatase; Region: Sulfatase; cl17466 316275004938 HMMPfam hit to PF00884, Sulfatase, score 1.6e-19 316275004940 hypothetical protein; Provisional; Region: PRK13689 316275004941 HMMPfam hit to PF07208, Protein of unknown function (DUF1414), score 5.3e-43 316275004942 Nucleoid-associated protein [General function prediction only]; Region: COG3081 316275004943 nucleoid-associated protein NdpA; Validated; Region: PRK00378 316275004944 HMMPfam hit to PF04245, 37-kD nucleoid-associated bacterial protein, score 4.9e-199 316275004946 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275004947 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275004948 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275004949 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275004950 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275004951 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275004952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275004953 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275004954 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase. UniProt:Q3IIG2 (EMBL:CR954246) (99 aa) fasta scores: E()=0.05, 35.294% id in 51 aa. CDS is contains a frameshift and a possible truncation of aa residues after codon 55 316275004955 ribonuclease D; Provisional; Region: PRK10829 316275004956 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 316275004957 catalytic site [active] 316275004958 putative active site [active] 316275004959 putative substrate binding site [chemical binding]; other site 316275004960 HRDC domain; Region: HRDC; pfam00570 316275004961 HMMPfam hit to PF01612, 3'-5' exonuclease, score 3.5e-52 316275004962 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 316275004963 HMMPfam hit to PF03776, Septum formation topological specificity fac, score 7.4e-49 316275004964 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 316275004965 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 316275004966 Switch I; other site 316275004967 Switch II; other site 316275004968 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 1.9e-23 316275004969 PS00017 ATP/GTP-binding site motif A (P-loop). 316275004970 septum formation inhibitor; Reviewed; Region: minC; PRK04804 316275004971 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 316275004972 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 316275004973 HMMPfam hit to PF03775, Septum formation inhibitor MinC, C-terminal, score 5.1e-60 316275004974 HMMPfam hit to PF05209, Septum formation inhibitor MinC, N-terminal, score 1.3e-28 316275004975 YcgL domain; Region: YcgL; pfam05166 316275004976 HMMPfam hit to PF05166, Family of unknown function (DUF709), score 2.8e-42 316275004977 Transglycosylase SLT domain; Region: SLT_2; pfam13406 316275004978 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275004979 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275004980 Predicted helix-turn-helix motif with score 1111.000, SD 2.97 at aa 32-53, sequence VNLKNEARENGISEPILERAFK 316275004981 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 316275004982 Uncharacterized conserved protein [Function unknown]; Region: COG4121 316275004983 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 316275004984 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 7.3e-42 316275004985 HMMPfam hit to PF06039, Malate:quinone oxidoreductase (Mqo), score 0.0037 316275004986 HMMPfam hit to PF05430, Protein of unknown function (DUF752), score 1.8e-130 316275004987 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 316275004988 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316275004989 dimer interface [polypeptide binding]; other site 316275004990 active site 316275004991 HMMPfam hit to PF00109, Beta-ketoacyl synthase,N-terminal do, score 1.1e-61 316275004992 PS00606 Beta-ketoacyl synthases active site. 316275004993 HMMPfam hit to PF02801, Beta-ketoacyl synthase,C-terminal do, score 1e-60 316275004994 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 316275004995 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 316275004996 ligand binding site [chemical binding]; other site 316275004997 NAD binding site [chemical binding]; other site 316275004998 catalytic site [active] 316275004999 homodimer interface [polypeptide binding]; other site 316275005000 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 5.6e-31 316275005001 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 3.3e-17 316275005002 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 316275005003 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316275005004 HMMPfam hit to PF01118, Semialdehyde dehydrogenase,NAD bindi, score 1e-47 316275005005 HMMPfam hit to PF02774, Semialdehyde dehydrogenase,dimerisat, score 2.4e-82 316275005006 PS01103 Aspartate-semialdehyde dehydrogenase signature. 316275005007 FimV N-terminal domain; Region: FimV_core; TIGR03505 316275005008 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 316275005010 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 316275005011 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 316275005012 dimerization interface 3.5A [polypeptide binding]; other site 316275005013 active site 316275005014 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 3.8e-33 316275005015 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 3.2e-33 316275005016 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 316275005017 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 316275005018 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 316275005019 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316275005020 HMMPfam hit to PF08245, Mur ligase middle domain,score 1.7e-06 316275005021 PS01011 Folylpolyglutamate synthase signature 1. 316275005022 PS01012 Folylpolyglutamate synthase signature 2. 316275005023 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 0.0019 316275005024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 316275005025 Sporulation related domain; Region: SPOR; pfam05036 316275005026 HMMPfam hit to PF05036, Sporulation related domain,score 1.2e-15 316275005027 Colicin V production protein; Region: Colicin_V; cl00567 316275005028 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 316275005029 HMMPfam hit to PF02674, Colicin V production protein, score 1.4e-56 316275005031 amidophosphoribosyltransferase; Provisional; Region: PRK09246 316275005032 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 316275005033 active site 316275005034 tetramer interface [polypeptide binding]; other site 316275005035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316275005036 active site 316275005037 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 4.9e-55 316275005038 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 2.5e-10 316275005039 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 316275005040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275005041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005042 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275005043 putative effector binding pocket; other site 316275005044 dimerization interface [polypeptide binding]; other site 316275005045 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-37 316275005046 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-16 316275005047 PS00044 Bacterial regulatory proteins, lysR family signature. 316275005048 Predicted helix-turn-helix motif with score 1024.000, SD 2.67 at aa 16-37, sequence GSYTAASRKTLIPVATITRRIQ 316275005049 Response regulator receiver domain; Region: Response_reg; pfam00072 316275005050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275005051 active site 316275005052 phosphorylation site [posttranslational modification] 316275005053 intermolecular recognition site; other site 316275005054 dimerization interface [polypeptide binding]; other site 316275005055 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.8e-32 316275005056 Protein of unknown function (DUF454); Region: DUF454; cl01063 316275005058 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005059 HMMPfam hit to PF04304, Protein of unknown function (DUF454), score 3.5e-12 316275005060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316275005061 active site 316275005062 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.4e-50 316275005063 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 316275005064 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 316275005065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275005066 Walker A motif; other site 316275005067 ATP binding site [chemical binding]; other site 316275005068 Walker B motif; other site 316275005069 DNA polymerase III subunit delta'; Validated; Region: PRK08485 316275005070 arginine finger; other site 316275005071 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 316275005072 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 316275005073 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 316275005074 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.6e-06 316275005075 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005076 hypothetical protein; Validated; Region: PRK00153 316275005077 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 3.1e-51 316275005078 recombination protein RecR; Reviewed; Region: recR; PRK00076 316275005079 RecR protein; Region: RecR; pfam02132 316275005080 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 316275005081 putative active site [active] 316275005082 putative metal-binding site [ion binding]; other site 316275005083 tetramer interface [polypeptide binding]; other site 316275005084 HMMPfam hit to PF02132, RecR protein, score 9.6e-18 316275005085 PS01300 RecR protein signature. 316275005086 HMMPfam hit to PF01751, Toprim domain, score 1.2e-19 316275005087 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 316275005088 HMMPfam hit to PF01694, Rhomboid family, score 1.2e-06 316275005090 CDS is disrupted by the insertion of an IS element after codon 68 316275005091 HMMPfam hit to PF03942, DTW domain, score 1.3e-48 316275005092 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275005093 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275005094 Integrase core domain; Region: rve; pfam00665 316275005095 HMMPfam hit to PF00665, Integrase core domain,score 2.8e-14 316275005096 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 24-45, sequence ISAREIGQKLKRSNGSISKELR 316275005097 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 316275005098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275005099 Zn2+ binding site [ion binding]; other site 316275005100 Mg2+ binding site [ion binding]; other site 316275005101 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 316275005102 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 316275005103 NAD(P) binding site [chemical binding]; other site 316275005104 catalytic residues [active] 316275005105 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 4.4e-50 316275005106 PS00211 ABC transporters family signature. 316275005107 PS00687 Aldehyde dehydrogenases glutamic acid active site. 316275005108 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275005109 EamA-like transporter family; Region: EamA; pfam00892 316275005110 EamA-like transporter family; Region: EamA; pfam00892 316275005112 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 4.9e-05 316275005113 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.5e-10 316275005114 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 316275005115 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 316275005116 dimer interface [polypeptide binding]; other site 316275005117 active site 316275005118 metal binding site [ion binding]; metal-binding site 316275005119 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.1e-13 316275005120 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 316275005121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275005122 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275005123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275005124 HMMPfam hit to PF06719, AraC-type transcriptional regulator N-termin, score 1.2e-55 316275005125 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.1e-07 316275005126 Predicted helix-turn-helix motif with score 1279.000, SD 3.54 at aa 212-233, sequence LTVQNLAEEANMSVSAFHSAFR 316275005127 PS00041 Bacterial regulatory proteins, araC family signature. 316275005128 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.2e-07 316275005129 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 316275005130 RibD C-terminal domain; Region: RibD_C; cl17279 316275005131 HMMPfam hit to PF01872, RibD C-terminal domain,score 8.8e-09 316275005132 aminotransferase AlaT; Validated; Region: PRK09265 316275005133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275005134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275005135 homodimer interface [polypeptide binding]; other site 316275005136 catalytic residue [active] 316275005137 HMMPfam hit to PF00155, Aminotransferase class I and II, score 3.3e-47 316275005138 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 316275005139 chorismate binding enzyme; Region: Chorismate_bind; cl10555 316275005140 HMMPfam hit to PF00425, chorismate binding enzyme,score 2.2e-75 316275005141 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 316275005142 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 316275005143 dimer interface [polypeptide binding]; other site 316275005144 tetramer interface [polypeptide binding]; other site 316275005145 PYR/PP interface [polypeptide binding]; other site 316275005146 TPP binding site [chemical binding]; other site 316275005147 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 316275005148 TPP-binding site; other site 316275005149 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 0.0013 316275005150 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 316275005151 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 1.7e-09 316275005152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316275005153 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 316275005154 substrate binding site [chemical binding]; other site 316275005155 oxyanion hole (OAH) forming residues; other site 316275005156 trimer interface [polypeptide binding]; other site 316275005157 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 3.9e-70 316275005158 PS00018 EF-hand calcium-binding domain. 316275005159 PS00166 Enoyl-CoA hydratase/isomerase signature. 316275005160 O-succinylbenzoate synthase; Provisional; Region: PRK05105 316275005161 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 316275005162 active site 316275005163 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 316275005164 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 316275005165 acyl-activating enzyme (AAE) consensus motif; other site 316275005166 putative AMP binding site [chemical binding]; other site 316275005167 putative active site [active] 316275005168 putative CoA binding site [chemical binding]; other site 316275005169 HMMPfam hit to PF00501, AMP-binding enzyme, score 8.7e-65 316275005170 PS00455 AMP-binding domain signature. 316275005171 Similar to Vibrio fischeri Macrolide-efflux protein UniProt:Q5E486 (622 aa) fasta scores: E()=6e-32, 64.740% id in 173 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events. N-terminal part located around 95 kb further upstream 316275005173 Similar to Pseudoalteromonas haloplanktis transposase UniProt:Q3IIG1 (115 aa) fasta scores: E()=3.5e-31, 57.4% id in 115 aa. CDS contains a frameshift after codon 27 316275005174 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=5.5e-113, 54.4% id in 491 aa. CDS contains a frameshift after codon 339 316275005175 Similar to Vibrio furnissii Chitodextrinase precursor Endo I UniProt:P96156 (1046 aa) fasta scores: E()=0, 76.510% id in 745 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events. CDS also appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275005176 HMMPfam hit to PF06483, Chitinase C, score 3.2e-59 316275005177 HMMPfam hit to PF00704, Glycosyl hydrolases family,score 6.5e-106 316275005178 PS01095 Chitinases family 18 active site. 316275005179 HMMPfam hit to PF00801, PKD domain, score 0.0043 316275005180 HMMPfam hit to PF02368, no description, score 0.016 316275005181 Protein of unknown function, DUF481; Region: DUF481; pfam04338 316275005182 HMMPfam hit to PF04338, Protein of unknown function, DUF481, score 2.9e-07 316275005183 Similar to N-terminal part of Vibrio fischeri Sensory box/GGDEF family protein UniProt:Q5E662 (631 aa) fasta scores: E()=2.1e-20, 60.000% id in 105 aa. The CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275005184 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316275005185 active site 316275005186 Similar to Vibrio cholerae IcmF-related protein UniProt:Q9KN45 (1181 aa) fasta scores: E()=4.6e-20,27.362% id in 307 aa. CDS contains a nonsense mutation (TAA) after codon 655. It also contains a frameshift after codon 818. The sequence has been checked and is believed to be correct 316275005187 HMMPfam hit to PF06744, Protein of unknown function (DUF1215), score 2.9e-30 316275005188 HMMPfam hit to PF06761, ImcF-related, score 7.9e-73 316275005189 PS00687 Aldehyde dehydrogenases glutamic acid active site. 316275005190 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005191 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 316275005193 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 316275005194 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 316275005195 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 6.8e-161 316275005196 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 316275005197 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005198 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 316275005199 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316275005200 phosphopeptide binding site; other site 316275005201 HMMPfam hit to PF00498, FHA domain, score 8.2e-10 316275005202 Similar to Vibrio fischeri Transcriptional regulator UniProt:Q5E653 (522 aa) fasta scores: E()=4.1e-137, 72.189% id in 507 aa. CDS contains a frameshift after codon 333. The sequence has been checked and is believed to be correct 316275005203 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis family, score 6.4e-07 316275005204 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275005205 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 6.5e-120 316275005206 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275005207 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 316275005208 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 316275005209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275005210 Walker A motif; other site 316275005211 ATP binding site [chemical binding]; other site 316275005212 Walker B motif; other site 316275005213 arginine finger; other site 316275005214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275005215 Walker A motif; other site 316275005216 ATP binding site [chemical binding]; other site 316275005217 Walker B motif; other site 316275005218 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316275005219 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.7e-05 316275005220 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.4e-84 316275005221 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005222 Predicted helix-turn-helix motif with score 977.000, SD 2.51 at aa 474-495, sequence LNQKELAEALLTSRINVAQCDD 316275005223 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.8e-10 316275005224 PS00870 Chaperonins clpA/B signature 1. 316275005225 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005226 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 316275005227 HMMPfam hit to PF06996, Protein of unknown function (DUF1305), score 1.7e-80 316275005228 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 316275005229 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 316275005230 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 2.5e-108 316275005231 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005232 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 316275005233 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 1.4e-20 316275005234 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 316275005235 Protein of unknown function (DUF877); Region: DUF877; pfam05943 316275005236 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 0 316275005237 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005238 Protein of unknown function (DUF770); Region: DUF770; pfam05591 316275005239 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 7.5e-64 316275005240 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 316275005241 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 316275005242 HMMPfam hit to PF06812, ImpA-related N-terminal,score 0.00014 316275005243 hypothetical protein; Provisional; Region: PRK11038 316275005244 Primosomal replication protein priB and priC; Region: priB_priC; pfam07445 316275005245 HMMPfam hit to PF07445, Primosomal replication protein priB and pri, score 3.3e-72 316275005246 hypothetical protein; Provisional; Region: PRK10621 316275005247 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316275005249 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 5.5e-32 316275005250 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 316275005251 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 316275005252 DEAD_2; Region: DEAD_2; pfam06733 316275005253 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 316275005254 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005255 Similar to Photobacterium damselae Porin-like protein P OmpP UniProt:Q71QD4 (338 aa) fasta scores: E()=2e-06, 28.013% id in 307 aa. CDS contains a nonsense mutation (TAA) after codon 65. The sequence has been checked and is believed to be correct 316275005256 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 316275005257 Gram-negative porin; Region: Porin_4; pfam13609 316275005258 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 316275005259 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 316275005260 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 316275005261 HMMPfam hit to PF01634, ATP phosphoribosyltransferase, score 5.6e-64 316275005262 PS01316 ATP phosphoribosyltransferase signature. 316275005263 HMMPfam hit to PF08029, HisG, C-terminal domain,score 6.4e-35 316275005264 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 316275005265 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 316275005266 NAD binding site [chemical binding]; other site 316275005267 dimerization interface [polypeptide binding]; other site 316275005268 product binding site; other site 316275005269 substrate binding site [chemical binding]; other site 316275005270 zinc binding site [ion binding]; other site 316275005271 catalytic residues [active] 316275005272 HMMPfam hit to PF00815, Histidinol dehydrogenase,score 5.8e-263 316275005273 PS00611 Histidinol dehydrogenase signature. 316275005274 histidinol-phosphate aminotransferase; Provisional; Region: PRK04635 316275005275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275005276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275005277 homodimer interface [polypeptide binding]; other site 316275005278 catalytic residue [active] 316275005279 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.9e-62 316275005280 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 316275005281 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 316275005282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275005283 active site 316275005284 motif I; other site 316275005285 motif II; other site 316275005286 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 316275005287 putative active site pocket [active] 316275005288 4-fold oligomerization interface [polypeptide binding]; other site 316275005289 metal binding residues [ion binding]; metal-binding site 316275005290 3-fold/trimer interface [polypeptide binding]; other site 316275005291 HMMPfam hit to PF00475, Imidazoleglycerol-phosphate dehydratase, score 6.6e-96 316275005292 PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 316275005293 PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 316275005294 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 316275005295 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 316275005296 putative active site [active] 316275005297 oxyanion strand; other site 316275005298 catalytic triad [active] 316275005299 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 7.9e-36 316275005300 PS00442 Glutamine amidotransferases class-I active site. 316275005301 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 316275005302 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 316275005303 catalytic residues [active] 316275005304 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 1.5e-108 316275005305 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 316275005306 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 316275005307 substrate binding site [chemical binding]; other site 316275005308 glutamase interaction surface [polypeptide binding]; other site 316275005309 HMMPfam hit to PF00977, Histidine biosynthesis protein, score 3e-117 316275005310 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 316275005311 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 316275005312 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 316275005313 metal binding site [ion binding]; metal-binding site 316275005314 HMMPfam hit to PF01502, Phosphoribosyl-AMP cyclohydrolase, score 1.4e-41 316275005315 HMMPfam hit to PF01503, Phosphoribosyl-ATP pyrophosphohydrolase, score 1.5e-47 316275005316 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 3.7e-08 316275005318 PS00409 Prokaryotic N-terminal methylation site. 316275005319 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316275005320 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316275005321 active site 316275005322 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.3e-39 316275005323 PS01129 Rlu family of pseudouridine synthase signature. 316275005324 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 316275005325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275005326 S-adenosylmethionine binding site [chemical binding]; other site 316275005327 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005328 YciI-like protein; Reviewed; Region: PRK11370 316275005329 HMMPfam hit to PF03795, YCII-related domain, score 1.5e-44 316275005330 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 316275005331 HMMPfam hit to PF03061, Thioesterase superfamily,score 1.7e-21 316275005332 intracellular septation protein A; Reviewed; Region: PRK00259 316275005333 HMMPfam hit to PF04279, Intracellular septation protein A, score 1.1e-102 316275005335 Similar to Escherichia coli Proton glutamate symport protein UniProt:P21345 (EMBL:ECGACAR) (437 aa) blastp scores: E()=8e-46. CDS contains a frameshift after codon 77. The sequence has been checked and is believed to be correct 316275005336 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 7.2e-104 316275005337 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 3.1e-42 316275005339 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 316275005340 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 316275005341 substrate binding site [chemical binding]; other site 316275005342 active site 316275005343 catalytic residues [active] 316275005344 heterodimer interface [polypeptide binding]; other site 316275005345 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 6.1e-130 316275005346 PS00167 Tryptophan synthase alpha chain signature. 316275005347 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 316275005348 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 316275005349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275005350 catalytic residue [active] 316275005351 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 3.4e-118 316275005352 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005353 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 316275005354 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 316275005355 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 316275005356 active site 316275005357 ribulose/triose binding site [chemical binding]; other site 316275005358 phosphate binding site [ion binding]; other site 316275005359 substrate (anthranilate) binding pocket [chemical binding]; other site 316275005360 product (indole) binding pocket [chemical binding]; other site 316275005361 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 316275005362 active site 316275005363 HMMPfam hit to PF00697,N-(5'phosphoribosyl)anthranilate (PRA) isome, score 1.5e-71 316275005364 HMMPfam hit to PF00218, Indole-3-glycerol phosphate synthase, score 1.4e-140 316275005365 PS00614 Indole-3-glycerol phosphate synthase signature. 316275005366 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 316275005367 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316275005368 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 316275005369 HMMPfam hit to PF00591, Glycosyl transferase family, a/b doma, score 9.8e-149 316275005370 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 9.2e-25 316275005371 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 316275005372 Glutamine amidotransferase class-I; Region: GATase; pfam00117 316275005373 glutamine binding [chemical binding]; other site 316275005374 catalytic triad [active] 316275005375 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.6e-63 316275005376 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005377 PS00442 Glutamine amidotransferases class-I active site. 316275005378 anthranilate synthase component I; Provisional; Region: PRK13564 316275005379 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 316275005380 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 316275005381 HMMPfam hit to PF00425, chorismate binding enzyme,score 3.4e-151 316275005382 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 3.8e-22 316275005383 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 316275005384 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 316275005385 active site 316275005386 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 316275005387 HMMPfam hit to PF02811, PHP domain, score 3.9e-32 316275005388 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 316275005389 HMMPfam hit to PF01300, yrdC domain, score 2.5e-62 316275005390 PS01147 SUA5/yciO/yrdC family signature. 316275005391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275005392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275005393 ATP binding site [chemical binding]; other site 316275005394 Mg2+ binding site [ion binding]; other site 316275005395 G-X-G motif; other site 316275005396 Response regulator receiver domain; Region: Response_reg; pfam00072 316275005397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275005398 active site 316275005399 phosphorylation site [posttranslational modification] 316275005400 intermolecular recognition site; other site 316275005401 dimerization interface [polypeptide binding]; other site 316275005402 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.4e-29 316275005403 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.1e-17 316275005404 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.0094 316275005406 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 316275005407 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275005408 RNA binding surface [nucleotide binding]; other site 316275005409 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 316275005410 probable active site [active] 316275005411 HMMPfam hit to PF01479, S4 domain, score 8.3e-09 316275005412 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 5.2e-09 316275005413 PS01149 Rsu family of pseudouridine synthase signature. 316275005414 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 316275005415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275005416 NAD(P) binding site [chemical binding]; other site 316275005417 active site 316275005418 HMMPfam hit to PF00106, short chain dehydrogenase,score 7.1e-21 316275005419 PS00061 Short-chain dehydrogenases/reductases family signature. 316275005420 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 316275005421 putative inner membrane peptidase; Provisional; Region: PRK11778 316275005422 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 316275005423 tandem repeat interface [polypeptide binding]; other site 316275005424 oligomer interface [polypeptide binding]; other site 316275005425 active site residues [active] 316275005426 HMMPfam hit to PF08496, Peptidase family S49 N-terminal, score 1.3e-99 316275005428 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005429 HMMPfam hit to PF01343, Peptidase family S49, score 5.3e-50 316275005430 hypothetical protein; Provisional; Region: PRK11037 316275005431 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 316275005432 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 316275005433 active site 316275005434 interdomain interaction site; other site 316275005435 putative metal-binding site [ion binding]; other site 316275005436 nucleotide binding site [chemical binding]; other site 316275005437 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 316275005438 domain I; other site 316275005439 DNA binding groove [nucleotide binding] 316275005440 phosphate binding site [ion binding]; other site 316275005441 domain II; other site 316275005442 domain III; other site 316275005443 nucleotide binding site [chemical binding]; other site 316275005444 catalytic site [active] 316275005445 domain IV; other site 316275005446 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316275005447 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 316275005448 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 316275005449 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 316275005450 HMMPfam hit to PF01751, Toprim domain, score 2.8e-32 316275005451 HMMPfam hit to PF01131, DNA topoisomerase, score 4.9e-165 316275005452 PS00396 Prokaryotic DNA topoisomerase I active site. 316275005453 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 0.0016 316275005454 HMMPfam hit to PF01396, Topoisomerase DNA binding C4 zinc fing, score 5.4e-08 316275005455 HMMPfam hit to PF08272, Topoisomerase I zinc-ribbon-like, score 1.3e-15 316275005456 HMMPfam hit to PF08272, Topoisomerase I zinc-ribbon-like, score 5.8e-19 316275005457 Similar to Vibrio fischeri transporter divalent anion:sodium symporter family UniProt:Q5E5Z9 (486 aa) fasta scores: E()=4.5e-101, 93.691% id in 312 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275005458 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 6.8e-05 316275005460 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275005461 Putative transposase; Region: Y2_Tnp; pfam04986 316275005462 Similar to Solibacter usitatus Twin-arginine translocation pathway signal UniProt:Q43WS8 (193 aa) fasta scores: E()=1.2e-18, 37.931% id in 174 aa. CDS contains a nonsense mutation (TAA) after codon 80. The sequence has been checked and is believed to be correct 316275005463 PAAR motif; Region: PAAR_motif; pfam05488 316275005464 HMMPfam hit to PF05488, PAAR motif, score 1.3 316275005465 PS00070 Aldehyde dehydrogenases cysteine active site. 316275005466 HMMPfam hit to PF05488, PAAR motif, score 3.8e-07 316275005467 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 316275005468 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 316275005469 Protein of unknown function (DUF796); Region: DUF796; pfam05638 316275005470 Protein of unknown function (DUF770); Region: DUF770; pfam05591 316275005471 HMMPfam hit to PF05591, Protein of unknown function (DUF770), score 2.8e-62 316275005472 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 316275005473 Protein of unknown function (DUF877); Region: DUF877; pfam05943 316275005474 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 1.2e-221 316275005475 PS00213 Lipocalin signature. 316275005476 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 316275005477 Protein of unknown function (DUF877); Region: DUF877; pfam05943 316275005478 HMMPfam hit to PF05943, Protein of unknown function (DUF877), score 2.7e-18 316275005479 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 316275005480 HMMPfam hit to PF07025, Protein of unknown function (DUF1316), score 3e-07 316275005481 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 316275005482 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 316275005483 HMMPfam hit to PF05947, Bacterial protein of unknown function (DUF87, score 9.9e-88 316275005484 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 316275005485 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 316275005486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275005487 Walker A motif; other site 316275005488 ATP binding site [chemical binding]; other site 316275005489 Walker B motif; other site 316275005490 arginine finger; other site 316275005491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275005492 Walker A motif; other site 316275005493 ATP binding site [chemical binding]; other site 316275005494 Walker B motif; other site 316275005495 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 316275005496 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.1e-10 316275005497 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005498 PS00870 Chaperonins clpA/B signature 1. 316275005499 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 4.4e-79 316275005500 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.1e-05 316275005501 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005502 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 316275005503 phosphopeptide binding site; other site 316275005504 HMMPfam hit to PF00498, FHA domain, score 3.7e-08 316275005505 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 316275005506 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 316275005507 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005508 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 316275005509 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 316275005510 HMMPfam hit to PF05936, Bacterial protein of unknown function (DUF87, score 4.7e-34 316275005511 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 316275005513 Similar to Vibrio cholerae IcmF-related protein UniProt:Q9KN45 (1181 aa) fasta scores: E()=1.9e-32,22.852% id in 1199 aa. CDS is disrupted by the insertion of an IS element after codon 805 316275005515 HMMPfam hit to PF06761, ImcF-related, score 1e-22 316275005516 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275005517 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275005518 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275005519 HMMPfam hit to PF01609, Transposase DDE domain,score 6.6e-10 316275005520 HMMPfam hit to PF06744, Protein of unknown function (DUF1215), score 5.9e-34 316275005521 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316275005522 substrate binding site [chemical binding]; other site 316275005523 activation loop (A-loop); other site 316275005524 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316275005526 HMMPfam hit to PF01810, LysE type translocator,score 2.5e-24 316275005527 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 316275005528 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275005529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275005530 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 1.2e-32 316275005531 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 2.4e-05 316275005532 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 194-215, sequence ISLEDLSQLSNLSAYHLVRSFQ 316275005533 PS00041 Bacterial regulatory proteins, araC family signature. 316275005534 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 4.3e-10 316275005535 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 316275005537 HMMPfam hit to PF03591, AzlC protein, score 1.2e-59 316275005538 Predicted membrane protein [Function unknown]; Region: COG4392 316275005540 HMMPfam hit to PF05437, Branched-chain amino acid transport protein, score 7.4e-34 316275005541 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 316275005542 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 316275005543 HMMPfam hit to PF01557, Fumarylacetoacetate (FAA) hydrolase fam, score 5.8e-15 316275005544 Helix-turn-helix domain; Region: HTH_18; pfam12833 316275005545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275005546 Predicted helix-turn-helix motif with score 1344.000, SD 3.76 at aa 177-198, sequence TPIAKLGELLHCSQRTLERSFL 316275005547 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.8e-05 316275005548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316275005549 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316275005550 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.9e-06 316275005551 peptidase T; Region: peptidase-T; TIGR01882 316275005552 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 316275005553 metal binding site [ion binding]; metal-binding site 316275005554 dimer interface [polypeptide binding]; other site 316275005555 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 316275005556 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 4.4e-05 316275005557 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 316275005558 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 7.2e-07 316275005559 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 316275005560 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 316275005561 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 1.6e-88 316275005563 HMMPfam hit to PF03600, Citrate transporter score 0.0036 316275005564 HMMPfam hit to PF03553, Na+/H+ antiporter family,score 0.00075 316275005565 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 316275005566 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 316275005567 GDP-binding site [chemical binding]; other site 316275005568 ACT binding site; other site 316275005569 IMP binding site; other site 316275005570 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 2.4e-178 316275005571 PS00107 Protein kinases ATP-binding region signature. 316275005572 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275005573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316275005575 dimerization interface [polypeptide binding]; other site 316275005576 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-13 316275005577 Predicted helix-turn-helix motif with score 1350.000, SD 3.78 at aa 19-40, sequence KHFGKTATALHMTQPNVSLHIK 316275005578 PS00044 Bacterial regulatory proteins, lysR family signature. 316275005579 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.1e-20 316275005580 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 316275005581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275005582 catalytic residue [active] 316275005583 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 9e-115 316275005584 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 316275005585 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 316275005586 TrkA-C domain; Region: TrkA_C; pfam02080 316275005587 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 316275005589 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 1.7e-33 316275005590 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005591 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 4.2e-26 316275005592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275005593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005594 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275005595 putative effector binding pocket; other site 316275005596 dimerization interface [polypeptide binding]; other site 316275005597 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.3e-44 316275005598 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.2e-20 316275005599 PS00044 Bacterial regulatory proteins, lysR family signature. 316275005600 Predicted helix-turn-helix motif with score 1641.000, SD 4.78 at aa 17-38, sequence GGITKAAEQLNLAKSAVSKRLS 316275005601 Pirin-related protein [General function prediction only]; Region: COG1741 316275005602 Pirin; Region: Pirin; pfam02678 316275005603 Male germ-cell putative homeodomain transcription factor; Region: Phtf-FEM1B_bdg; pfam12129 316275005604 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 316275005605 HMMPfam hit to PF02678, Pirin, score 1.3e-55 316275005606 HMMPfam hit to PF05726, Pirin C-terminal cupin domain, score 7.4e-38 316275005607 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 316275005608 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 316275005609 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 316275005610 putative dimer interface [polypeptide binding]; other site 316275005611 N-terminal domain interface [polypeptide binding]; other site 316275005612 putative substrate binding pocket (H-site) [chemical binding]; other site 316275005613 HMMPfam hit to PF00043, Glutathione S-transferase,C-terminal domain, score 0.00014 316275005614 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 316275005615 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 7.1e-73 316275005616 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 316275005617 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 316275005618 active site 316275005619 nucleophile elbow; other site 316275005620 lysophospholipase L2; Provisional; Region: PRK10749 316275005621 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316275005622 HMMPfam hit to PF01734, Patatin-like phospholipase,score 8.6e-14 316275005623 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 2.5e-13 316275005624 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275005625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005626 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275005627 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275005628 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275005629 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275005630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005631 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E5X8 (317 aa) fasta scores: E()=2.1e-87, 68.770% id in 317 aa. The insertion of the downstream IS element truncates the original stop codon of the CDS. There is an inframe translational stop codon 10 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275005632 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275005633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275005634 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275005635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316275005636 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316275005637 HMMPfam hit to PF01408, Oxidoreductase family,NAD-binding Ross, score 2.4e-30 316275005638 HMMPfam hit to PF03447, Homoserine dehydrogenase,NAD binding d, score 0.0034 316275005639 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 316275005640 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 316275005641 Predicted helix-turn-helix motif with score 1296.000, SD 3.60 at aa 25-46, sequence CNITELSLLLKVSERHVQTVIK 316275005642 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 5.6e-07 316275005643 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 316275005644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275005645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275005646 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275005647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275005648 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 3.3e-07 316275005649 PS00041 Bacterial regulatory proteins, araC family signature. 316275005650 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pr, score 3.3e-12 316275005651 Predicted helix-turn-helix motif with score 1268.000, SD 3.51 at aa 190-211, sequence MSISEIAKESGLSDFYLIHSFK 316275005652 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 8.8e-10 316275005653 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316275005654 HMMPfam hit to PF01810, LysE type translocator,score 2.3e-09 316275005656 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316275005657 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3.8e-16 316275005658 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 316275005660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275005661 salt bridge; other site 316275005662 non-specific DNA binding site [nucleotide binding]; other site 316275005663 sequence-specific DNA binding site [nucleotide binding]; other site 316275005664 Predicted helix-turn-helix motif with score 1689.000, SD 4.94 at aa 16-37, sequence MRLKHLAQEVGITEANLSILKN 316275005665 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 316275005666 PS00079 Multicopper oxidases signature 1. 316275005667 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275005668 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275005669 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275005670 Similar to Vibrio vulnificus Threonine aldolase UniProt:Q7MEZ7 (358 aa) fasta scores: E()=2.7e-05, 44.898% id in 49 aa. CDS may be truncated by the insertion of the upstream IS element and subsequent recombination events 316275005671 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 316275005672 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 8.3e-137 316275005674 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900 316275005676 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 316275005677 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275005678 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 1.4e-07 316275005679 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005680 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 316275005681 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316275005682 DNA binding site [nucleotide binding] 316275005683 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 2.8e-05 316275005684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316275005685 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 316275005686 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 316275005687 HMMPfam hit to PF03600, Citrate transporter score 0.0028 316275005688 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 4.8e-217 316275005690 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005691 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 316275005692 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 316275005693 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 316275005695 HMMPfam hit to PF06808, DctM-like transporters,score 3.6e-12 316275005696 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316275005697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275005698 substrate binding pocket [chemical binding]; other site 316275005699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275005700 membrane-bound complex binding site; other site 316275005701 hinge residues; other site 316275005703 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1.6e-19 316275005704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275005705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316275005707 dimerization interface [polypeptide binding]; other site 316275005708 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 3.6e-18 316275005709 Predicted helix-turn-helix motif with score 1483.000, SD 4.24 at aa 17-38, sequence GSFSAAARKLGKAQSAVSTAIA 316275005710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275005711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005712 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275005713 putative effector binding pocket; other site 316275005714 dimerization interface [polypeptide binding]; other site 316275005715 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.4e-20 316275005716 Predicted helix-turn-helix motif with score 1913.000, SD 5.70 at aa 18-39, sequence GSFTAAAKQMGVSTSHVSKQLG 316275005717 HMMPfam hit to PF03466, LysR substrate binding domain, score 7.2e-51 316275005718 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 316275005719 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 316275005720 Nucleoside recognition; Region: Gate; pfam07670 316275005721 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 316275005722 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 8.1e-35 316275005724 HMMPfam hit to PF07670, Nucleoside recognition,score 9.4e-14 316275005725 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 1.9e-107 316275005727 HMMPfam hit to PF00082, Subtilase family, score 1.6e-88 316275005728 PS00137 Serine proteases, subtilase family,histidine active site. 316275005729 PS00138 Serine proteases, subtilase family, serine active site. 316275005730 HMMPfam hit to PF02839, Carbohydrate binding domain, score 4.9e-06 316275005731 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275005732 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005733 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=1.3e-119, 56.5% id in 494 aa. CDS contains a frameshift after codon 363 316275005734 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275005735 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275005736 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 5.2e-11 316275005737 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 316275005738 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 316275005739 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 0.008 316275005740 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 316275005741 substrate binding site [chemical binding]; other site 316275005742 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 4.2e-50 316275005743 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 316275005744 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 316275005745 HMMPfam hit to PF00144, Beta-lactamase, score 5.3e-31 316275005746 PS00146 Beta-lactamase class-A active site. 316275005748 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 316275005749 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 316275005750 catalytic residue [active] 316275005751 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316275005752 active site 316275005753 HMMPfam hit to PF01844, HNH endonuclease, score 9.3e-05 316275005755 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 316275005757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275005758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275005760 dimerization interface [polypeptide binding]; other site 316275005761 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.3e-18 316275005762 Predicted helix-turn-helix motif with score 2058.000, SD 6.20 at aa 21-42, sequence GSQQAAAKALGLPVSTVSRRLS 316275005763 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.1e-13 316275005764 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 316275005766 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 316275005767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005768 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275005769 dimerization interface [polypeptide binding]; other site 316275005770 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.3e-17 316275005771 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-16 316275005772 PS00044 Bacterial regulatory proteins, lysR family signature. 316275005773 Predicted helix-turn-helix motif with score 2121.000, SD 6.41 at aa 24-45, sequence GTLTKAADELCVTPTAVSKQIK 316275005774 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 316275005775 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 316275005776 HMMPfam hit to PF02129, X-Pro dipeptidyl-peptidase (S15 family), score 1.9e-81 316275005777 HMMPfam hit to PF08530, X-Pro dipeptidyl-peptidase C-terminal n, score 1.2e-57 316275005778 BCCT family transporter; Region: BCCT; pfam02028 316275005780 HMMPfam hit to PF02028, BCCT family transporterscore 3.9e-66 316275005781 chaperone protein DnaJ; Provisional; Region: PRK14299 316275005782 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316275005783 HSP70 interaction site [polypeptide binding]; other site 316275005784 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 316275005785 substrate binding site [polypeptide binding]; other site 316275005786 dimer interface [polypeptide binding]; other site 316275005787 HMMPfam hit to PF00226, DnaJ domain, score 7.8e-38 316275005788 PS00636 Nt-dnaJ domain signature. 316275005789 HMMPfam hit to PF01556, DnaJ C terminal region,score 1.6e-56 316275005790 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275005791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005792 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=3.5e-120, 57.1% id in 496 aa. CDS contains a frameshift after codon 220 316275005793 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 316275005794 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 316275005795 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 316275005796 putative active site [active] 316275005797 HMMPfam hit to PF01380, SIS domain, score 6.2e-06 316275005798 HMMPfam hit to PF01418, Helix-turn-helix domain,rpiR family, score 3.1e-29 316275005799 Predicted helix-turn-helix motif with score 1253.000, SD 3.45 at aa 35-56, sequence YSSQELANRVQVSQSSIIKLTQ 316275005800 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 316275005801 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 316275005802 putative active site [active] 316275005803 PS01272 Glucokinase regulatory protein family signature. 316275005804 Similar to Vibrio fischeri PTS system,sucrose-specific IIBC component UniProt:Q5E5T6 (484 aa) fasta scores: E()=2.1e-40, 48.554% id in 484 aa. CDS contains frameshifts after codon 112 and 159 and appears to have a deletion of around 200 amino acid residues after codon 180 in comparison to orthologues. The sequence has been checked and is believed to be correct 316275005805 HMMPfam hit to PF00367, phosphotransferase system,EIIB, score 5e-14 316275005806 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 316275005808 YaeQ protein; Region: YaeQ; pfam07152 316275005809 HMMPfam hit to PF07152, YaeQ protein, score 1.8e-98 316275005810 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316275005812 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 1.1e-35 316275005813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275005814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275005815 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275005816 putative effector binding pocket; other site 316275005817 dimerization interface [polypeptide binding]; other site 316275005818 HMMPfam hit to PF03466, LysR substrate binding domain, score 9.7e-41 316275005819 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.4e-17 316275005820 Predicted helix-turn-helix motif with score 1665.000, SD 4.86 at aa 55-76, sequence KSLSAAADHLDMSRAKVSRYLA 316275005821 Similar to Vibrio cholerae Hypothetical protein UniProt:Q9KKQ3 (292 aa) fasta scores: E()=1.3e-06, 54.902% id in 51 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275005822 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase (is66 family element,orf2-like). UniProt:Q3IIG1 (EMBL:CR954246) (115 aa) fasta scores: E()=6e-32, 58.261% id in 115 aa. CDS contains a frameshift after codon 46 316275005823 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=2.2e-113, 55.4% id in 498 aa. CDS contains a frameshift after codon 258 316275005824 TSCPD domain; Region: TSCPD; pfam12637 316275005825 PS00190 Cytochrome c family heme-binding site signature. 316275005826 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 316275005827 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 316275005828 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 316275005829 active site 316275005830 dimer interface [polypeptide binding]; other site 316275005831 effector binding site; other site 316275005832 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 316275005833 HMMPfam hit to PF02867, Ribonucleotide reductase,barrel doma, score 1.6e-13 316275005834 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275005835 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275005836 metal binding site [ion binding]; metal-binding site 316275005837 active site 316275005838 I-site; other site 316275005840 HMMPfam hit to PF00990, GGDEF domain, score 1.9e-48 316275005841 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316275005842 putative active site [active] 316275005843 HMMPfam hit to PF02698, DUF218 domain, score 9.1e-43 316275005845 Protein of unknown function (DUF3392); Region: DUF3392; pfam11872 316275005847 malate dehydrogenase; Provisional; Region: PRK13529 316275005848 Malic enzyme, N-terminal domain; Region: malic; pfam00390 316275005849 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 316275005850 NAD(P) binding site [chemical binding]; other site 316275005851 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 2.1e-140 316275005852 PS00331 Malic enzymes signature. 316275005853 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 6.2e-121 316275005854 Similar to Escherichia coli ATP-dependent RNA helicase HrpB UniProt:P37024 (809 aa) fasta scores: E()=9.2e-30, 31.140% id in 456 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275005855 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1.4e-06 316275005856 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.7e-11 316275005857 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 0.0052 316275005858 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275005859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275005860 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275005861 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E4I9 (446 aa) fasta scores: E()=1.7e-89, 84.337% id in 249 aa. CDS is truncated by the insertion of the upstream and downstream IS elements and subsequent recombination events 316275005862 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275005863 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005864 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275005865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005866 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275005867 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275005868 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275005869 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 316275005870 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 316275005871 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 9.1e-121 316275005873 BCCT family transporter; Region: BCCT; pfam02028 316275005875 HMMPfam hit to PF02028, BCCT family transporterscore 5.8e-153 316275005876 PS01303 BCCT family of transporters signature. 316275005877 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 316275005878 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 316275005880 Ecdysteroid kinase; Region: EcKinase; cl17738 316275005881 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 316275005882 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 1.3e-15 316275005883 Uncharacterized conserved protein [Function unknown]; Region: COG1432 316275005884 LabA_like proteins; Region: LabA; cd10911 316275005885 putative metal binding site [ion binding]; other site 316275005886 HMMPfam hit to PF01936, Protein of unknown function DUF88, score 1.4e-72 316275005887 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 316275005888 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 316275005889 active site 316275005890 Ca binding site [ion binding]; other site 316275005891 catalytic site [active] 316275005892 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 2e-39 316275005893 HMMPfam hit to PF00691, OmpA family, score 5.5e-36 316275005894 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275005895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005896 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275005897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275005898 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275005899 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275005900 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275005901 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 1.4e-12 316275005903 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275005904 dimerization interface [polypeptide binding]; other site 316275005905 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275005906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275005907 dimer interface [polypeptide binding]; other site 316275005908 putative CheW interface [polypeptide binding]; other site 316275005909 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.4e-57 316275005910 HMMPfam hit to PF00672, HAMP domain, score 2.9e-10 316275005912 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 316275005913 nucleotide binding site/active site [active] 316275005914 HIT family signature motif; other site 316275005915 catalytic residue [active] 316275005916 HMMPfam hit to PF01230, HIT domain, score 6.2e-52 316275005917 PS00892 HIT family signature. 316275005918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 316275005919 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005920 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0066 316275005921 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 316275005922 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 316275005923 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 316275005924 putative dimer interface [polypeptide binding]; other site 316275005925 HMMPfam hit to PF07233, Protein of unknown function (DUF1425), score 2.4e-49 316275005926 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005927 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 316275005928 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275005931 Protein with unknown function (DUF469); Region: DUF469; pfam04320 316275005932 HMMPfam hit to PF04320, Protein with unknown function (DUF469), score 2.5e-15 316275005933 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316275005934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275005935 S-adenosylmethionine binding site [chemical binding]; other site 316275005936 HMMPfam hit to PF08241, Methyltransferase domain,score 4.8e-10 316275005937 HMMPfam hit to PF08242, Methyltransferase domain,score 2.9e-09 316275005938 hypothetical protein; Provisional; Region: PRK10621 316275005939 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316275005941 HMMPfam hit to PF01925, Domain of unknown function DUF81, score 4.3e-27 316275005942 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 316275005943 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 316275005944 HMMPfam hit to PF03446, NAD binding domain of 6-phosphoglucona, score 1.9e-70 316275005945 HMMPfam hit to PF03721, UDP-glucose/GDP-mannose dehydrogenase, score 0.0014 316275005946 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 316275005947 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 316275005948 substrate binding pocket [chemical binding]; other site 316275005949 active site 316275005950 iron coordination sites [ion binding]; other site 316275005951 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 316275005952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316275005953 DNA-binding site [nucleotide binding]; DNA binding site 316275005954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275005955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275005956 homodimer interface [polypeptide binding]; other site 316275005957 catalytic residue [active] 316275005958 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR fam, score 1.9e-13 316275005959 Predicted helix-turn-helix motif with score 1124.000, SD 3.02 at aa 29-50, sequence PPHRELANELSTTPATIAKAYK 316275005960 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.3e-07 316275005961 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316275005962 thiamine kinase; Region: ycfN_thiK; TIGR02721 316275005963 active site 316275005964 substrate binding site [chemical binding]; other site 316275005965 ATP binding site [chemical binding]; other site 316275005966 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 316275005967 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 8.7e-18 316275005968 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275005969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275005970 Homeodomain-like domain; Region: HTH_23; cl17451 316275005971 Winged helix-turn helix; Region: HTH_29; pfam13551 316275005972 Homeodomain-like domain; Region: HTH_32; pfam13565 316275005973 hypothetical protein; Provisional; Region: PRK04940 316275005974 HMMPfam hit to PF05728, Uncharacterised protein family (UPF0227), score 4.4e-94 316275005975 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 316275005976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275005977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275005978 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 8.3e-20 316275005979 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 0.0046 316275005980 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 1.1e-17 316275005981 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 316275005982 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275005983 ATP binding site [chemical binding]; other site 316275005984 Mg++ binding site [ion binding]; other site 316275005985 motif III; other site 316275005986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275005987 nucleotide binding region [chemical binding]; other site 316275005988 ATP-binding site [chemical binding]; other site 316275005989 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 2.6e-62 316275005990 PS00017 ATP/GTP-binding site motif A (P-loop). 316275005991 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275005992 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.4e-34 316275005993 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase (is66 family element,orf2-like). UniProt:Q3IIG1 (EMBL:CR954246) (115 aa) fasta scores: E()=1.7e-31,57.391% id in 115 aa. CDS contains a frameshift after codon 53 316275005994 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.9e-115, 55.172% id in 493 aa. CDS contains a frameshift after codon 301 316275005995 Similar to Vibrio fischeri Carbon starvation protein A UniProt:Q5E5Q4 (488 aa) fasta scores: E()=8.1e-158, 90.369% id in 488 aa. CDS contains a nonsense mutation (TAT or TAC to TAG) after codon 357. The sequence has been checked and is believed to be correct 316275005997 HMMPfam hit to PF02554, Carbon starvation protein CstA, score 1.5e-61 316275005998 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 316275005999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275006000 active site 316275006001 phosphorylation site [posttranslational modification] 316275006002 intermolecular recognition site; other site 316275006003 dimerization interface [polypeptide binding]; other site 316275006004 LytTr DNA-binding domain; Region: LytTR; smart00850 316275006005 HMMPfam hit to PF04397, LytTr DNA-binding domain,score 9.3e-20 316275006006 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.3e-27 316275006007 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 316275006008 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 316275006009 GAF domain; Region: GAF; cl17456 316275006010 Histidine kinase; Region: His_kinase; pfam06580 316275006011 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 316275006012 Mg2+ binding site [ion binding]; other site 316275006013 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 0.00015 316275006014 HMMPfam hit to PF06580, Histidine kinase, score 1.4e-40 316275006015 HMMPfam hit to PF01590, GAF domain, score 0.00023 316275006017 HMMPfam hit to PF07694, 5TMR of 5TMR-LYT, score 9e-38 316275006018 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 316275006019 HMMPfam hit to PF01184, GPR1/FUN34/yaaH family,score 4.1e-51 316275006021 heat shock protein HtpX; Provisional; Region: PRK05457 316275006022 HMMPfam hit to PF06509, HtpX N-terminus, score 4.5e-54 316275006024 HMMPfam hit to PF01435, Peptidase family M48, score 3.4e-43 316275006025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 316275006026 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 316275006027 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 316275006028 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 4.8e-26 316275006029 HMMPfam hit to PF07308, Protein of unknown function (DUF1456), score 1e-27 316275006030 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 316275006031 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 316275006032 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 4.9e-77 316275006034 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 316275006035 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 316275006036 active site 316275006037 putative substrate binding pocket [chemical binding]; other site 316275006038 HMMPfam hit to PF01979, Amidohydrolase family,score 1.4e-60 316275006039 HMMPfam hit to PF07969, Amidohydrolase family,score 3e-05 316275006040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 316275006041 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316275006042 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316275006043 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 316275006044 HMMPfam hit to PF01471, peptidoglycan binding domain, score 2.9e-05 316275006045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 316275006046 Peptidase M15; Region: Peptidase_M15_3; cl01194 316275006048 HMMPfam hit to PF05951, Bacterial protein of unknown function, score 1.4e-89 316275006049 HMMPfam hit to PF08291, Peptidase M15, score 1.4e-06 316275006050 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 316275006051 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 316275006052 putative dimer interface [polypeptide binding]; other site 316275006053 putative anticodon binding site; other site 316275006054 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 316275006055 homodimer interface [polypeptide binding]; other site 316275006056 motif 1; other site 316275006057 motif 2; other site 316275006058 active site 316275006059 motif 3; other site 316275006060 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 4.8e-72 316275006061 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275006062 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275006063 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 4.7e-17 316275006064 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 316275006065 active site 316275006066 HMMPfam hit to PF01242, 6-pyruvoyl tetrahydropterin synthase, score 7e-61 316275006067 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316275006068 putative catalytic site [active] 316275006069 putative metal binding site [ion binding]; other site 316275006070 putative phosphate binding site [ion binding]; other site 316275006071 HMMPfam hit to PF03372,Endonuclease/Exonuclease/phosphatase fa, score 3.6e-06 316275006072 exonuclease subunit SbcD; Provisional; Region: PRK10966 316275006073 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 316275006074 active site 316275006075 metal binding site [ion binding]; metal-binding site 316275006076 DNA binding site [nucleotide binding] 316275006077 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 316275006078 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1e-14 316275006079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275006080 Walker A/P-loop; other site 316275006081 ATP binding site [chemical binding]; other site 316275006082 Q-loop/lid; other site 316275006083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275006084 ABC transporter signature motif; other site 316275006085 Walker B; other site 316275006086 D-loop; other site 316275006087 H-loop/switch region; other site 316275006088 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 6.3e-08 316275006089 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006090 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 316275006091 HMMPfam hit to PF03061, Thioesterase superfamily,score 1.6e-17 316275006092 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275006093 Putative transposase; Region: Y2_Tnp; pfam04986 316275006094 Similar to N-terminal part of Vibrio cholerae non-O1 Multidrug efflux pump VcmH UniProt:Q4W668 (458 aa) fasta scores: E()=4.6e-09, 62.963% id in 54 aa. The CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275006096 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 316275006097 aromatic amino acid transport protein; Region: araaP; TIGR00837 316275006098 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 2.5e-53 316275006100 Similar to Escherichia coli Tyrosine-specific transport protein (Tyrosine permease) UniProt:P0AAD4 (403 aa) fasta scores: E()=2.4e-26, 32.824% id in 393 aa. CDS is disrupted by the insertion of an IS element after codon 384. There is an inframe translational stop codon 6 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275006101 HMMPfam hit to PF01490, Transmembrane amino acid transporter pro, score 0.00027 316275006102 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 1e-45 316275006104 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275006105 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006106 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 316275006107 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006108 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 316275006109 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006110 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 316275006111 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 316275006112 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 316275006113 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 1.3e-187 316275006114 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 2.5e-88 316275006115 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 316275006116 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 316275006118 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 4.5e-05 316275006119 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 316275006120 putative active site [active] 316275006121 putative CoA binding site [chemical binding]; other site 316275006122 nudix motif; other site 316275006123 metal binding site [ion binding]; metal-binding site 316275006124 HMMPfam hit to PF00293, NUDIX domain, score 1.1e-09 316275006125 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 316275006126 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 316275006127 chorismate binding enzyme; Region: Chorismate_bind; cl10555 316275006128 HMMPfam hit to PF00425, chorismate binding enzyme,score 1.6e-120 316275006129 HMMPfam hit to PF04715, Anthranilate synthase component I, N, score 8.2e-27 316275006130 putative fumarate hydratase; Provisional; Region: PRK15392 316275006131 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 316275006132 Fumarase C-terminus; Region: Fumerase_C; pfam05683 316275006133 HMMPfam hit to PF05681, Fumarate hydratase (Fumerase), score 2.4e-153 316275006134 HMMPfam hit to PF05683, Fumarase C-terminus, score 2.2e-111 316275006135 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275006136 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006137 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275006138 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275006139 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006140 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275006141 HMMPfam hit to PF01609, Transposase DDE domain,score 7.6e-28 316275006142 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 316275006143 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006144 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275006145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275006146 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275006147 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006148 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275006149 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275006150 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275006151 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006152 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00041 316275006153 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316275006154 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family,score 5.1e-95 316275006156 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 316275006157 cystathionine beta-lyase; Provisional; Region: PRK09028 316275006158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 316275006159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275006160 catalytic residue [active] 316275006161 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 7.3e-135 316275006162 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 316275006163 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 316275006164 HMMPfam hit to PF05638, Protein of unknown function (DUF796), score 4.8e-74 316275006165 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 316275006166 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 316275006167 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 316275006168 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 316275006169 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 5e-49 316275006170 HMMPfam hit to PF06715, Gp5 C-terminal repeat (3 copies), score 0.021 316275006171 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 316275006172 Similar to Vibrio fischeri MJ11 uncharacterized protein. UniProt:A9ICK7 (EMBL:ABIH01000005) (844 aa) fasta scores: E()=2.2e-165,68.9% id in 675 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events. There is an inframe translational stop codon one amino acid residue further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275006173 HMMPfam hit to PF01476, LysM domain, score 2e-08 316275006174 PS00070 Aldehyde dehydrogenases cysteine active site. 316275006175 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=3e-120, 56.680% id in 494 aa. CDS contains a frameshift after codon 97 316275006176 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275006177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275006178 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 316275006179 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 316275006180 generic binding surface I; other site 316275006181 generic binding surface II; other site 316275006182 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316275006183 putative catalytic site [active] 316275006184 putative metal binding site [ion binding]; other site 316275006185 putative phosphate binding site [ion binding]; other site 316275006186 HMMPfam hit to PF03372,Endonuclease/Exonuclease/phosphatase fa, score 4.4e-17 316275006187 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275006188 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006189 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275006190 DNA ligase; Provisional; Region: PRK09125 316275006191 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 316275006192 DNA binding site [nucleotide binding] 316275006193 active site 316275006194 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 316275006195 DNA binding site [nucleotide binding] 316275006196 HMMPfam hit to PF01068, ATP dependent DNA ligase domain, score 1.3e-07 316275006197 transcriptional repressor RbsR; Provisional; Region: PRK10423 316275006198 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275006199 DNA binding site [nucleotide binding] 316275006200 domain linker motif; other site 316275006201 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 316275006202 dimerization interface [polypeptide binding]; other site 316275006203 ligand binding site [chemical binding]; other site 316275006204 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 4.6e-24 316275006205 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.2e-11 316275006206 Predicted helix-turn-helix motif with score 2209.000, SD 6.71 at aa 21-42, sequence ATIKDVAKHAGVSTSTVSHVLN 316275006207 PS00356 Bacterial regulatory proteins, lacI family signature. 316275006208 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316275006209 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 316275006210 substrate binding site [chemical binding]; other site 316275006211 dimer interface [polypeptide binding]; other site 316275006212 ATP binding site [chemical binding]; other site 316275006213 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 2.5e-89 316275006214 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase, score 4.3e-06 316275006215 PS00584 pfkB family of carbohydrate kinases signature 2. 316275006216 PS00583 pfkB family of carbohydrate kinases signature 1. 316275006217 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 316275006218 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 316275006219 ligand binding site [chemical binding]; other site 316275006220 dimerization interface [polypeptide binding]; other site 316275006221 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 3.5e-12 316275006222 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 316275006223 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 316275006224 TM-ABC transporter signature motif; other site 316275006225 HMMPfam hit to PF02653, Branched-chain amino acid transport syst, score 1.3e-76 316275006227 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 316275006228 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 316275006229 Walker A/P-loop; other site 316275006230 ATP binding site [chemical binding]; other site 316275006231 Q-loop/lid; other site 316275006232 ABC transporter signature motif; other site 316275006233 Walker B; other site 316275006234 D-loop; other site 316275006235 H-loop/switch region; other site 316275006236 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 316275006237 HMMPfam hit to PF00005, ABC transporter score 3.2e-27 316275006238 PS00211 ABC transporters family signature. 316275006239 HMMPfam hit to PF00005, ABC transporter score 2.7e-51 316275006240 PS00211 ABC transporters family signature. 316275006241 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006242 D-ribose pyranase; Provisional; Region: PRK11797 316275006243 HMMPfam hit to PF05025, RbsD / FucU transport protein family, score 2.8e-73 316275006244 hypothetical protein; Provisional; Region: PRK11770 316275006245 Domain of unknown function (DUF307); Region: DUF307; pfam03733 316275006246 Domain of unknown function (DUF307); Region: DUF307; pfam03733 316275006247 HMMPfam hit to PF03733, Domain of unknown function (DUF307), score 7.6e-20 316275006249 HMMPfam hit to PF03733, Domain of unknown function (DUF307), score 1.1e-27 316275006251 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 316275006252 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006253 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275006254 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275006255 Homeodomain-like domain; Region: HTH_23; cl17451 316275006256 Winged helix-turn helix; Region: HTH_29; pfam13551 316275006257 Homeodomain-like domain; Region: HTH_32; pfam13565 316275006258 Similar to N-terminal part of Vibrio fischeri Hypothetical protein UniProt:Q5DYX7 (205 aa) fasta scores: E()=1.6e-51, 79.245% id in 159 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275006259 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 316275006260 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006261 multidrug efflux protein; Reviewed; Region: PRK01766 316275006262 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 316275006263 cation binding site [ion binding]; other site 316275006265 HMMPfam hit to PF01554, MatE, score 2.1e-44 316275006266 HMMPfam hit to PF01554, MatE, score 1e-42 316275006267 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 316275006268 Lumazine binding domain; Region: Lum_binding; pfam00677 316275006269 Lumazine binding domain; Region: Lum_binding; pfam00677 316275006270 HMMPfam hit to PF00677, Lumazine binding domain,score 1e-33 316275006271 PS00693 Riboflavin synthase alpha chain family signature. 316275006272 HMMPfam hit to PF00677, Lumazine binding domain,score 4.1e-23 316275006273 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 316275006274 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316275006275 Phosphotransferase enzyme family; Region: APH; pfam01636 316275006276 active site 316275006277 ATP binding site [chemical binding]; other site 316275006278 HMMPfam hit to PF03881, Fructosamine kinase, score 2.1e-140 316275006279 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 2.4e-25 316275006280 Protein of unknown function (DUF3802); Region: DUF3802; pfam12290 316275006281 NlpC/P60 family; Region: NLPC_P60; pfam00877 316275006282 HMMPfam hit to PF00877, NlpC/P60 family, score 1.1e-42 316275006283 AbgT putative transporter family; Region: ABG_transport; pfam03806 316275006284 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 316275006285 HMMPfam hit to PF03806, AbgT transporter family, score 0 316275006287 PS00019 Actinin-type actin-binding domain signature 1. 316275006288 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 316275006289 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275006290 RNA binding surface [nucleotide binding]; other site 316275006291 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 316275006292 active site 316275006293 uracil binding [chemical binding]; other site 316275006294 HMMPfam hit to PF01479, S4 domain, score 4.1e-06 316275006295 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 6.1e-10 316275006296 PS01149 Rsu family of pseudouridine synthase signature. 316275006297 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 316275006298 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 316275006300 Uncharacterized conserved protein [Function unknown]; Region: COG3148 316275006301 HMMPfam hit to PF03942, DTW domain, score 5.9e-56 316275006302 fructokinase; Reviewed; Region: PRK09557 316275006303 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316275006304 nucleotide binding site [chemical binding]; other site 316275006305 HMMPfam hit to PF00480, ROK family, score 2.8e-47 316275006306 PS01125 ROK family signature. 316275006307 SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102 316275006308 SEC-C motif; Region: SEC-C; pfam02810 316275006309 HMMPfam hit to PF02810, SEC-C motif, score 0.00039 316275006310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316275006311 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 316275006312 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275006314 DinI-like family; Region: DinI; cl11630 316275006315 HMMPfam hit to PF06183, DinI-like family, score 3.4e-13 316275006316 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491 316275006317 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 316275006318 Walker A motif; other site 316275006319 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 316275006320 dimer interface [polypeptide binding]; other site 316275006321 putative functional site; other site 316275006322 putative MPT binding site; other site 316275006323 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 2e-19 316275006324 HMMPfam hit to PF00994, molybdopterin binding domain, score 2e-50 316275006325 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 316275006326 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 6.3e-54 316275006327 HMMPfam hit to PF03205, Molybdopterin guanine dinucleotide synt, score 2.5e-48 316275006328 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006329 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 316275006330 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 316275006331 GTP binding site; other site 316275006332 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316275006333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275006334 Walker A/P-loop; other site 316275006335 ATP binding site [chemical binding]; other site 316275006336 Q-loop/lid; other site 316275006337 ABC transporter signature motif; other site 316275006338 Walker B; other site 316275006339 D-loop; other site 316275006340 H-loop/switch region; other site 316275006341 HMMPfam hit to PF00005, ABC transporter score 3.7e-38 316275006342 PS00211 ABC transporters family signature. 316275006343 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006344 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0018 316275006346 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 316275006347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316275006348 Similar to Escherichia coli Acetoacetate metabolism regulatory protein AtoC UniProt:Q06065 (461 aa), score E()=6e-78. CDS contains a frameshift after codon 83. The sequence has been checked and is believed to be correct 316275006349 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.4e-33 316275006350 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 3.9e-134 316275006351 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00025 316275006352 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 316275006353 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275006354 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275006355 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 1.4e-10 316275006356 Predicted helix-turn-helix motif with score 1664.000, SD 4.85 at aa 352-373, sequence GNKSAAARQLGVARKTLERKFK 316275006357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275006358 dimer interface [polypeptide binding]; other site 316275006359 phosphorylation site [posttranslational modification] 316275006360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275006361 ATP binding site [chemical binding]; other site 316275006362 Mg2+ binding site [ion binding]; other site 316275006363 G-X-G motif; other site 316275006365 HMMPfam hit to PF00672, HAMP domain, score 2.7e-07 316275006366 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.2e-11 316275006367 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 9.9e-28 316275006368 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316275006369 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 316275006370 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 6.5e-18 316275006371 Predicted membrane protein [Function unknown]; Region: COG4125 316275006372 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 316275006373 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 316275006374 HMMPfam hit to PF05232, Bacterial Transmembrane Pair family, score 1.5e-09 316275006376 HMMPfam hit to PF05232, Bacterial Transmembrane Pair family, score 2e-20 316275006377 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 316275006378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316275006379 active site 316275006380 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.3e-22 316275006381 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316275006382 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316275006384 Similar to Bacillus subtilis Glycine betaine transporter OpuD UniProt:P54417 (512 aa) fasta scores: E()=7e-41, 33.126% id in 483 aa. CDS is disrupted by the insertion of an IS element after codon 295 316275006385 HMMPfam hit to PF02028, BCCT family transporterscore 8.8e-59 316275006387 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275006388 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006389 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275006392 HMMPfam hit to PF02839, Carbohydrate binding domain, score 4.7e-13 316275006393 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275006394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275006395 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275006396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275006397 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275006398 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275006399 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275006400 PS00761 Signal peptidases I signature 3. 316275006401 HMMPfam hit to PF00182, Chitinase class I, score 1.6e-22 316275006402 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 316275006403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275006404 Coenzyme A binding pocket [chemical binding]; other site 316275006405 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 3.3e-15 316275006406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275006407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316275006408 Coenzyme A binding pocket [chemical binding]; other site 316275006409 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.7e-06 316275006410 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 316275006411 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316275006412 putative NAD(P) binding site [chemical binding]; other site 316275006413 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 316275006414 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 316275006415 active site residue [active] 316275006416 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 316275006417 active site residue [active] 316275006418 HMMPfam hit to PF00581, Rhodanese-like domain,score 2.9e-18 316275006419 HMMPfam hit to PF00581, Rhodanese-like domain,score 3.2e-11 316275006420 Similar to Vibrio fischeri Acetyltransferase, GNAT family UniProt:Q5E515 (148 aa) fasta scores: E()=6.3e-33,68.056% id in 144 aa. CDS contains a nonsense mutation (TAG) after codon 68. The sequence has been checked and is believed to be correct 316275006421 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316275006422 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.3e-08 316275006423 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275006424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275006425 Homeodomain-like domain; Region: HTH_23; cl17451 316275006426 Winged helix-turn helix; Region: HTH_29; pfam13551 316275006427 Homeodomain-like domain; Region: HTH_32; pfam13565 316275006428 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 316275006429 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316275006430 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 316275006431 putative N-terminal domain interface [polypeptide binding]; other site 316275006432 putative dimer interface [polypeptide binding]; other site 316275006433 putative substrate binding pocket (H-site) [chemical binding]; other site 316275006434 HMMPfam hit to PF00462, Glutaredoxin, score 0.004 316275006435 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E518 (747 aa) fasta scores: E()=0, 78.267% id in 750 aa. CDS is disrupted by the insertion of an IS element after codon 229 316275006436 HMMPfam hit to PF01136, Peptidase family U32, score 7.5e-28 316275006437 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275006438 Putative transposase; Region: Y2_Tnp; pfam04986 316275006439 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316275006440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316275006441 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 0.0001 316275006442 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 316275006443 Similar to Bacillus subtilis GltR UniProt:P94501 (296 aa) fasta scores: E()=4.4e-14, 26.749% id in 243 aa. CDS contains a nonsense mutation (TAA) after codon 211. The sequence has been checked and is believed to be correct 316275006444 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-26 316275006445 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 2e-18 316275006446 PS00044 Bacterial regulatory proteins, lysR family signature. 316275006447 Predicted helix-turn-helix motif with score 1561.000, SD 4.50 at aa 44-65, sequence GSFRKAAKHLCTTQPAISTRIA 316275006448 hypothetical protein; Provisional; Region: PRK05463 316275006449 HMMPfam hit to PF07286, Protein of unknown function (DUF1445), score 2.2e-95 316275006450 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 316275006451 putative active site [active] 316275006452 HMMPfam hit to PF03746, LamB/YcsF family, score 8.7e-115 316275006453 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 316275006454 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 316275006455 HMMPfam hit to PF02682, Allophanate hydrolase subunit, score 4e-50 316275006456 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 316275006457 HMMPfam hit to PF02626, Allophanate hydrolase subunit, score 3.2e-69 316275006458 Similar to Pseudoalteromonas haloplanktis transposase UniProt:Q3IIG1 (115 aa) fasta scores: E()=8.1e-32, 58.3% id in 115 aa. CDS is disrupted by an IS element after codon 82 316275006459 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 6.2e-18 316275006460 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275006461 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006462 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275006463 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275006464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275006465 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275006466 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275006467 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275006468 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 316275006470 Similar to Pseudomonas aeruginosa Transducer (Chemotactic transducer PctA) UniProt:Q51509 (629 aa) fasta scores: E()=6.4e-53, 33.076% id in 647 aa. CDS contains a frameshift after codon 17 and is disrupted by the insertion of an IS element after codon 65. The sequence has been checked and is believed to be correct 316275006471 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275006472 Putative transposase; Region: Y2_Tnp; pfam04986 316275006473 HMMPfam hit to PF02743, Cache domain, score 7.3e-11 316275006475 HMMPfam hit to PF00672, HAMP domain, score 4.1e-19 316275006476 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1e-58 316275006477 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 316275006478 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 316275006479 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275006480 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275006481 catalytic residue [active] 316275006482 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006483 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 6.7e-34 316275006484 PS00922 Prokaryotic transglycosylases signature. 316275006485 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 316275006486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275006487 substrate binding pocket [chemical binding]; other site 316275006488 membrane-bound complex binding site; other site 316275006489 hinge residues; other site 316275006490 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275006491 membrane-bound complex binding site; other site 316275006492 hinge residues; other site 316275006493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275006494 Zn2+ binding site [ion binding]; other site 316275006495 Mg2+ binding site [ion binding]; other site 316275006497 HMMPfam hit to PF01966, HD domain, score 6e-22 316275006498 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 316275006499 HMMPfam hit to PF02634, FdhD/NarQ family, score 4.8e-16 316275006500 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 316275006501 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 316275006502 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316275006503 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316275006504 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00056 316275006505 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 6.4e-05 316275006506 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00055 316275006507 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275006508 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 1.3e-06 316275006509 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275006510 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 316275006511 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD,score 1.3e-35 316275006512 formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811 316275006514 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 316275006515 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 316275006516 [4Fe-4S] binding site [ion binding]; other site 316275006517 molybdopterin cofactor binding site; other site 316275006518 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 316275006519 molybdopterin cofactor binding site; other site 316275006520 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 3.2e-16 316275006521 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 316275006522 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.2e-44 316275006523 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006524 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 2.4e-31 316275006525 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 316275006526 4Fe-4S binding domain; Region: Fer4; cl02805 316275006527 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 1e-07 316275006528 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275006529 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 316275006530 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 316275006532 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316275006533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316275006534 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 5.6e-14 316275006535 No significant database matches. CDS is truncated by the insertion of the downstream IS element. There is an inframe translational stop codon one amino acid residue further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275006536 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275006537 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006538 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275006539 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275006540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275006541 Predicted helix-turn-helix motif with score 1187.000, SD 3.23 at aa 170-191, sequence HKIENVCSILGVSKATLIRRLK 316275006542 PS00041 Bacterial regulatory proteins, araC family signature. 316275006543 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.9e-06 316275006544 Similar to Vibrio fischeri Sensory box/GGDEF family protein UniProt:Q5E050 (289 aa) fasta scores: E()=4e-45,68.018% id in 222 aa. CDS contains a nonsense mutation (TAG) after codon 80. In addition the CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275006545 HMMPfam hit to PF00563, EAL domain, score 1.6e-11 316275006547 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275006548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275006549 Homeodomain-like domain; Region: HTH_23; cl17451 316275006550 Winged helix-turn helix; Region: HTH_29; pfam13551 316275006551 Homeodomain-like domain; Region: HTH_32; pfam13565 316275006552 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.6e-33 316275006553 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275006554 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275006555 Integrase core domain; Region: rve; pfam00665 316275006556 HMMPfam hit to PF00665, Integrase core domain,score 1.1e-31 316275006557 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 24-45, sequence ISAREIGQKLKRSNGSISKELR 316275006558 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 316275006559 Similar to Vibrio cholerae Hypothetical protein VCA0423 UniProt:Q9KMD8 (119 aa) fasta scores: E()=1.3e-10,59.649% id in 57 aa. The CDS appears to be truncated at the N-terminus and lack similarity at the C-terminus in comparison to other orthologues. The sequence has been checked and is believed to be correct 316275006560 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 0.00036 316275006561 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 316275006562 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 5.6e-15 316275006563 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 316275006564 HMMPfam hit to PF02604, Phd_YefM, score 8.2e-12 316275006565 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 316275006566 Phosphotransferase enzyme family; Region: APH; pfam01636 316275006567 active site 316275006568 substrate binding site [chemical binding]; other site 316275006569 ATP binding site [chemical binding]; other site 316275006570 HMMPfam hit to PF01636, Phosphotransferase enzyme family, score 4.6e-10 316275006571 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 316275006572 nudix motif; other site 316275006573 HMMPfam hit to PF00293, NUDIX domain, score 1.4e-14 316275006574 PS00893 mutT domain signature. 316275006575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316275006576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275006577 Coenzyme A binding pocket [chemical binding]; other site 316275006578 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.4e-18 316275006579 Similar to N-terminus of Vibrio cholerae Hypothetical protein VC1574 UniProt:Q9KRR2 (127 aa) fasta scores: E()=3.5e-13, 70.213% id in 47 aa. The CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275006580 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275006582 Homeodomain-like domain; Region: HTH_23; cl17451 316275006583 Winged helix-turn helix; Region: HTH_29; pfam13551 316275006584 Homeodomain-like domain; Region: HTH_32; pfam13565 316275006585 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275006586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275006587 Similar to Bacillus sp. Hypothetical protein UniProt:Q2B5J8 (355 aa) fasta scores: E()=2e-28, 34.347% id in 329 aa. CDS is truncated at the N-terminus by the insertion of the upstream IS element 316275006588 HMMPfam hit to PF01757, Acyltransferase family,score 5.6e-06 316275006590 Similar to Pseudoalteromonas atlantica t6c Hypothetical protein UniProt:Q3CS45 (200 aa) fasta scores: E()=8.3e-08, 43.750% id in 80 aa. The CDS appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275006592 hypothetical protein; Provisional; Region: PRK09781; cl08057 316275006593 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006594 short chain dehydrogenase; Provisional; Region: PRK06123 316275006595 classical (c) SDRs; Region: SDR_c; cd05233 316275006596 NAD(P) binding site [chemical binding]; other site 316275006597 active site 316275006598 HMMPfam hit to PF00106, short chain dehydrogenase,score 9.2e-22 316275006599 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.0033 316275006600 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 316275006601 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 316275006602 classical (c) SDRs; Region: SDR_c; cd05233 316275006603 NAD(P) binding site [chemical binding]; other site 316275006604 active site 316275006605 HMMPfam hit to PF00106, short chain dehydrogenase,score 1.9e-12 316275006606 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 316275006607 MOSC domain; Region: MOSC; pfam03473 316275006608 HMMPfam hit to PF03473, MOSC domain, score 4.5e-38 316275006609 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316275006610 DNA-binding site [nucleotide binding]; DNA binding site 316275006611 RNA-binding motif; other site 316275006612 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 316275006613 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 9.9e-06 316275006615 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006616 Flagellin N-methylase; Region: FliB; pfam03692 316275006617 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 3.1e-18 316275006618 Leucine rich repeat; Region: LRR_8; pfam13855 316275006619 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 316275006620 HMMPfam hit to PF00560, Leucine Rich Repeat, score 2.7 316275006621 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 316275006622 Homeodomain-like domain; Region: HTH_23; cl17451 316275006623 Winged helix-turn helix; Region: HTH_29; pfam13551 316275006624 Homeodomain-like domain; Region: HTH_32; pfam13565 316275006625 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275006626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275006627 Similar to Vibrio parahaemolyticus Prt UniProt:Q56696 (816 aa) fasta scores: E()=3e-144, 44.568% id in 810 aa. CDS contains a nonsense mutation (TAG) after codon 242. The sequence has been checked and is believed to be correct 316275006628 HMMPfam hit to PF04151, Bacterial pre-peptidase C-terminal domai, score 1.6e-11 316275006629 HMMPfam hit to PF01752, Collagenase, score 3.1e-129 316275006630 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275006631 HMMPfam hit to PF08453, Peptidase family M9 N-terminal, score 1.8e-09 316275006632 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 316275006633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275006634 Coenzyme A binding pocket [chemical binding]; other site 316275006635 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2e-14 316275006636 C factor cell-cell signaling protein; Provisional; Region: PRK09009 316275006637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275006638 NAD(P) binding site [chemical binding]; other site 316275006639 active site 316275006640 Similar to N-terminal part of Vibrio fischeri Acetyltransferase UniProt:Q5E557 (155 aa) fasta scores: E()=3.7e-19, 63.514% id in 74 aa. The CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275006641 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006643 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 316275006644 putative active site [active] 316275006645 YdjC motif; other site 316275006646 Mg binding site [ion binding]; other site 316275006647 putative homodimer interface [polypeptide binding]; other site 316275006648 HMMPfam hit to PF04794, YdjC-like protein, score 1.1e-44 316275006649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275006650 Coenzyme A binding pocket [chemical binding]; other site 316275006651 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.4e-14 316275006652 CCGSCS motif protein; Region: CCGSCS; TIGR04101 316275006653 maltose O-acetyltransferase; Provisional; Region: PRK10092 316275006654 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 316275006655 active site 316275006656 substrate binding site [chemical binding]; other site 316275006657 trimer interface [polypeptide binding]; other site 316275006658 CoA binding site [chemical binding]; other site 316275006659 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.14 316275006660 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 9.9 316275006661 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.049 316275006662 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 316275006663 HMMPfam hit to PF06476, Protein of unknown function (DUF1090), score 1.4e-21 316275006664 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 316275006665 HMMPfam hit to PF02567, Phenazine biosynthesis-like protein, score 6.5e-69 316275006666 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275006667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316275006668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316275006669 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-07 316275006670 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316275006671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275006672 S-adenosylmethionine binding site [chemical binding]; other site 316275006673 HMMPfam hit to PF08242, Methyltransferase domain,score 0.00074 316275006675 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316275006676 CoenzymeA binding site [chemical binding]; other site 316275006677 subunit interaction site [polypeptide binding]; other site 316275006678 PHB binding site; other site 316275006679 HMMPfam hit to PF03061, Thioesterase superfamily,score 0.0027 316275006680 Uncharacterized conserved protein [Function unknown]; Region: COG3791 316275006681 HMMPfam hit to PF04828, Protein of unknown function (DUF636), score 7.2e-05 316275006683 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 316275006684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275006685 Zn2+ binding site [ion binding]; other site 316275006686 Mg2+ binding site [ion binding]; other site 316275006687 HMMPfam hit to PF01966, HD domain, score 3.9e-07 316275006688 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 316275006689 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 316275006690 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 9.2e-05 316275006691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275006692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275006693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275006694 dimerization interface [polypeptide binding]; other site 316275006695 HMMPfam hit to PF03466, LysR substrate binding domain, score 0.00016 316275006696 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.1e-15 316275006697 PS00044 Bacterial regulatory proteins, lysR family signature. 316275006698 Predicted helix-turn-helix motif with score 2002.000, SD 6.01 at aa 24-45, sequence MSFTLAADELHVTQSAVSRQVK 316275006699 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 316275006700 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316275006701 cation binding site [ion binding]; other site 316275006703 HMMPfam hit to PF01554, MatE, score 8.7e-21 316275006704 HMMPfam hit to PF01554, MatE, score 7.6e-21 316275006705 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 316275006706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275006707 S-adenosylmethionine binding site [chemical binding]; other site 316275006708 HMMPfam hit to PF08241, Methyltransferase domain,score 0.00021 316275006709 HMMPfam hit to PF08242, Methyltransferase domain,score 1.9e-10 316275006711 VRR-NUC domain; Region: VRR_NUC; cl17748 316275006712 Similar to part of Vibrio vulnificus Arginase/agmatinase/formimionoglutamate hydrolase UniProt:Q8D7B7 (402 aa) fasta scores: E()=2.5e-55, 54.962% id in 262 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events. CDS also seems to be truncated in the N-terminal part 316275006713 PS00147 Arginase family signature 1. 316275006714 PS00148 Arginase family signature 2. 316275006715 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275006716 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275006718 Similar to C-terminal part of Vibrio fischeri Hypothetical protein UniProt:Q5E496 (799 aa) fasta scores: E()=1.8e-196, 85.095% id in 577 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275006720 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316275006721 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316275006723 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 3.7e-30 316275006724 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E5E4 (664 aa) fasta scores: E()=1.6e-168,68.453% id in 653 aa. CDS contains a frameshift after codon 121 and may be truncated at the N-terminus. The sequence has been checked and is believed to be correct; CDS contains a frameshift after codon 121 316275006725 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006726 Protein of unknown function, DUF417; Region: DUF417; cl01162 316275006727 HMMPfam hit to PF04224, Protein of unknown function, DUF417, score 1.3e-50 316275006729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275006730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275006731 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 8.5e-12 316275006732 PS01081 Bacterial regulatory proteins, tetR family signature. 316275006733 Predicted helix-turn-helix motif with score 1512.000, SD 4.34 at aa 25-46, sequence TSMDKITAATGLSKATIYKYFQ 316275006734 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 316275006735 dimer interface [polypeptide binding]; other site 316275006736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316275006737 metal binding site [ion binding]; metal-binding site 316275006738 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 2.9e-09 316275006739 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 316275006740 GSH binding site [chemical binding]; other site 316275006741 catalytic residues [active] 316275006742 HMMPfam hit to PF00462, Glutaredoxin, score 5.3e-17 316275006743 PS00195 Glutaredoxin active site. 316275006744 Uncharacterized conserved protein [Function unknown]; Region: COG0398 316275006745 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316275006747 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 316275006748 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 316275006749 active site 316275006750 putative substrate binding pocket [chemical binding]; other site 316275006751 HMMPfam hit to PF01979, Amidohydrolase family,score 1.3e-54 316275006752 HMMPfam hit to PF07969, Amidohydrolase family,score 4.1e-06 316275006753 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275006754 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275006755 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316275006756 substrate binding pocket [chemical binding]; other site 316275006757 membrane-bound complex binding site; other site 316275006758 hinge residues; other site 316275006759 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 4e-33 316275006760 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 316275006761 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 316275006763 elongation factor P; Provisional; Region: PRK04542 316275006764 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 316275006765 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 316275006766 RNA binding site [nucleotide binding]; other site 316275006767 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 316275006768 RNA binding site [nucleotide binding]; other site 316275006769 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 2.9e-11 316275006770 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 8.3e-16 316275006771 PS01275 Elongation factor P signature. 316275006772 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 316275006774 HMMPfam hit to PF06738, Protein of unknown function (DUF1212), score 3.4e-32 316275006775 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 316275006776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275006777 S-adenosylmethionine binding site [chemical binding]; other site 316275006778 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 316275006779 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 9.5e-41 316275006780 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 316275006781 mce related protein; Region: MCE; pfam02470 316275006782 mce related protein; Region: MCE; pfam02470 316275006783 mce related protein; Region: MCE; pfam02470 316275006784 mce related protein; Region: MCE; pfam02470 316275006785 mce related protein; Region: MCE; pfam02470 316275006786 mce related protein; Region: MCE; pfam02470 316275006787 HMMPfam hit to PF02470, mce related protein, score 4.8e-06 316275006788 HMMPfam hit to PF02470, mce related protein, score 1.2e-18 316275006789 HMMPfam hit to PF02470, mce related protein, score 1.2e-10 316275006790 HMMPfam hit to PF02470, mce related protein, score 3.7e-05 316275006791 HMMPfam hit to PF02470, mce related protein, score 4.3e-13 316275006792 HMMPfam hit to PF02470, mce related protein, score 8.3e-08 316275006793 HMMPfam hit to PF02470, mce related protein, score 5.8e-28 316275006795 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 316275006796 Paraquat-inducible protein A; Region: PqiA; pfam04403 316275006797 Paraquat-inducible protein A; Region: PqiA; pfam04403 316275006798 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.9e-77 316275006800 HMMPfam hit to PF04403, Paraquat-inducible protein A, score 1.7e-58 316275006801 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316275006802 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316275006803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275006804 Walker A/P-loop; other site 316275006805 ATP binding site [chemical binding]; other site 316275006806 Q-loop/lid; other site 316275006807 ABC transporter signature motif; other site 316275006808 Walker B; other site 316275006809 D-loop; other site 316275006810 H-loop/switch region; other site 316275006811 HMMPfam hit to PF00005, ABC transporter score 1.4e-58 316275006812 PS00211 ABC transporters family signature. 316275006813 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006814 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 4.6e-25 316275006816 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 316275006817 GAF domain; Region: GAF_2; pfam13185 316275006818 PS01320 Uncharacterized protein family UPF0067 signature. 316275006819 ProP expression regulator; Provisional; Region: PRK04950 316275006820 ProQ/FINO family; Region: ProQ; pfam04352 316275006821 HMMPfam hit to PF04352, ProQ activator of osmoprotectant transporter score 5e-80 316275006822 carboxy-terminal protease; Provisional; Region: PRK11186 316275006823 B melanoma antigen family; Region: BAGE; pfam08180 316275006824 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 316275006825 protein binding site [polypeptide binding]; other site 316275006826 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 316275006827 Catalytic dyad [active] 316275006828 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 316275006829 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.8e-13 316275006830 HMMPfam hit to PF03572, Peptidase family S41, score 1.2e-64 316275006831 Similar to Escherichia coli Aminopeptidase N PepN UniProt:P04825 (869 aa) fasta scores: E()=1.9e-209,60.686% id in 875 aa. CDS contains a nonsense mutation (CAG to TAG) after codon 493. The sequence has been checked and is believed to be correct 316275006832 HMMPfam hit to PF01433, Peptidase family M1, score 5.2e-67 316275006833 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275006834 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 316275006835 Similar to Pseudomonas aeruginosa NAD-dependent glutamate dehydrogenase GdhB UniProt:Q9HZE0 (1620 aa) fasta scores: E()=0, 46.617% id in 1596 aa. CDS contains a frameshift after codon 1046. The sequence has been checked and is believed to be correct 316275006836 HMMPfam hit to PF05088, Bacterial NAD-glutamate dehydrogenase, score 0 316275006837 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006838 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 316275006839 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 316275006840 quinone interaction residues [chemical binding]; other site 316275006841 active site 316275006842 catalytic residues [active] 316275006843 FMN binding site [chemical binding]; other site 316275006844 substrate binding site [chemical binding]; other site 316275006845 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 1.2e-94 316275006846 PS00911 Dihydroorotate dehydrogenase signature 1. 316275006847 PS00912 Dihydroorotate dehydrogenase signature 2. 316275006848 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 316275006849 HMMPfam hit to PF07126, Protein of unknown function (DUF1379), score 9.5e-84 316275006850 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 316275006851 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 316275006852 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 316275006853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275006854 S-adenosylmethionine binding site [chemical binding]; other site 316275006855 HMMPfam hit to PF02926, THUMP domain, score 5.4e-05 316275006856 HMMPfam hit to PF01170, RNA methylase family UPF0020, score 2e-78 316275006857 PS01261 Uncharacterized protein family UPF0020 signature. 316275006858 PS00092 N-6 Adenine-specific DNA methylases signature. 316275006859 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 316275006860 HMMPfam hit to PF05768, Glutaredoxin-like domain (DUF836), score 9.3e-24 316275006861 ABC transporter ATPase component; Reviewed; Region: PRK11147 316275006862 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275006863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275006864 ABC transporter; Region: ABC_tran_2; pfam12848 316275006865 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275006866 HMMPfam hit to PF00005, ABC transporter score 5.7e-50 316275006867 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006868 PS00211 ABC transporters family signature. 316275006869 HMMPfam hit to PF00005, ABC transporter score 2e-46 316275006870 PS00017 ATP/GTP-binding site motif A (P-loop). 316275006871 PS00211 ABC transporters family signature. 316275006872 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 316275006873 ribosome modulation factor; Provisional; Region: PRK14563 316275006874 HMMPfam hit to PF04957, Ribosome modulation factor,score 5.2e-36 316275006875 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 316275006876 active site 1 [active] 316275006877 dimer interface [polypeptide binding]; other site 316275006878 active site 2 [active] 316275006879 HMMPfam hit to PF07977, FabA-like domain, score 3.6e-71 316275006880 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 316275006881 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316275006882 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 316275006883 HMMPfam hit to PF06303, Protein of unknown function (DUF1047), score 2e-96 316275006884 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 316275006885 HMMPfam hit to PF07273, Protein of unknown function (DUF1439), score 1e-24 316275006886 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275006888 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275006889 dimer interface [polypeptide binding]; other site 316275006890 phosphorylation site [posttranslational modification] 316275006891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275006892 ATP binding site [chemical binding]; other site 316275006893 Mg2+ binding site [ion binding]; other site 316275006894 G-X-G motif; other site 316275006895 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316275006896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275006897 active site 316275006898 phosphorylation site [posttranslational modification] 316275006899 intermolecular recognition site; other site 316275006900 dimerization interface [polypeptide binding]; other site 316275006901 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.3e-33 316275006902 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 6.1e-41 316275006903 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 5.5e-23 316275006904 Uncharacterized conserved protein [Function unknown]; Region: COG3287 316275006905 FIST N domain; Region: FIST; pfam08495 316275006906 FIST C domain; Region: FIST_C; pfam10442 316275006907 HMMPfam hit to PF08495, Domain of unknown function (DUF1745), score 4.8e-64 316275006909 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 316275006910 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 316275006911 Low-spin heme binding site [chemical binding]; other site 316275006912 Putative water exit pathway; other site 316275006913 Binuclear center (active site) [active] 316275006914 Putative proton exit pathway; other site 316275006915 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 9.3e-81 316275006917 PS00077 Heme-copper oxidase catalytic subunit,copper B binding region signature. 316275006918 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 316275006919 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 316275006920 HMMPfam hit to PF02433, Cytochrome C oxidase,mono-heme subunit/FixO, score 1.3e-90 316275006922 PS00190 Cytochrome c family heme-binding site signature. 316275006923 Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545 316275006924 HMMPfam hit to PF05545, Cbb3-type cytochrome oxidase component FixQ, score 3e-07 316275006926 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 316275006927 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316275006928 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 316275006930 HMMPfam hit to PF00034, Cytochrome c, score 0.00076 316275006931 PS00190 Cytochrome c family heme-binding site signature. 316275006932 HMMPfam hit to PF00034, Cytochrome c, score 7.5e-05 316275006933 PS00190 Cytochrome c family heme-binding site signature. 316275006934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 316275006935 FixH; Region: FixH; pfam05751 316275006937 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 316275006938 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 316275006939 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 316275006940 metal-binding site [ion binding] 316275006941 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316275006942 Soluble P-type ATPase [General function prediction only]; Region: COG4087 316275006943 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1.6e-06 316275006945 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.2e-67 316275006946 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 9.2e-27 316275006947 PS00154 E1-E2 ATPases phosphorylation site. 316275006948 PS01229 Hypothetical cof family signature 2. 316275006949 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 316275006950 HMMPfam hit to PF03597, Cytochrome oxidase maturation protein cbb3-t, score 3.3e-21 316275006952 Family description; Region: DsbD_2; pfam13386 316275006954 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 316275006955 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316275006956 ligand binding site [chemical binding]; other site 316275006957 flexible hinge region; other site 316275006958 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 316275006959 putative switch regulator; other site 316275006960 non-specific DNA interactions [nucleotide binding]; other site 316275006961 DNA binding site [nucleotide binding] 316275006962 sequence specific DNA binding site [nucleotide binding]; other site 316275006963 putative cAMP binding site [chemical binding]; other site 316275006964 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 9.6e-19 316275006965 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 1e-13 316275006966 PS00042 Bacterial regulatory proteins, crp family signature. 316275006967 Predicted helix-turn-helix motif with score 1841.000, SD 5.46 at aa 195-216, sequence MTRGDIGNYLGLTVETISRLLG 316275006968 universal stress protein UspE; Provisional; Region: PRK11175 316275006969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316275006970 Ligand Binding Site [chemical binding]; other site 316275006971 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316275006972 Ligand Binding Site [chemical binding]; other site 316275006973 HMMPfam hit to PF00582, Universal stress protein family, score 1e-12 316275006974 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 316275006975 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 316275006976 Ligand Binding Site [chemical binding]; other site 316275006977 HMMPfam hit to PF01171, PP-loop family, score 2.5e-07 316275006978 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275006979 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275006980 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275006981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275006982 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275006983 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275006984 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275006985 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 316275006986 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 316275006987 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 0.0098 316275006988 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275006989 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 316275006991 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 316275006992 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 316275006993 Walker A/P-loop; other site 316275006994 ATP binding site [chemical binding]; other site 316275006995 Q-loop/lid; other site 316275006996 ABC transporter signature motif; other site 316275006997 Walker B; other site 316275006998 D-loop; other site 316275006999 H-loop/switch region; other site 316275007000 TOBE domain; Region: TOBE_2; pfam08402 316275007001 HMMPfam hit to PF00005, ABC transporter score 6.2e-66 316275007002 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007003 PS00211 ABC transporters family signature. 316275007004 HMMPfam hit to PF08402, TOBE domain, score 5.7e-11 316275007005 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316275007006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275007007 dimer interface [polypeptide binding]; other site 316275007008 conserved gate region; other site 316275007009 putative PBP binding loops; other site 316275007010 ABC-ATPase subunit interface; other site 316275007012 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.2e-18 316275007013 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275007014 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316275007015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275007016 dimer interface [polypeptide binding]; other site 316275007017 conserved gate region; other site 316275007018 putative PBP binding loops; other site 316275007019 ABC-ATPase subunit interface; other site 316275007021 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.8e-09 316275007022 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275007023 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 316275007024 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 316275007025 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 2.5e-06 316275007026 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 316275007027 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 316275007028 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 1.8e-12 316275007029 NAD-dependent deacetylase; Provisional; Region: PRK00481 316275007030 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 316275007031 NAD+ binding site [chemical binding]; other site 316275007032 substrate binding site [chemical binding]; other site 316275007033 Zn binding site [ion binding]; other site 316275007034 HMMPfam hit to PF02146, Sir2 family, score 1.7e-69 316275007035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275007036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275007037 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275007038 putative effector binding pocket; other site 316275007039 dimerization interface [polypeptide binding]; other site 316275007040 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.7e-18 316275007041 Predicted helix-turn-helix motif with score 1761.000, SD 5.18 at aa 18-39, sequence QSFTKAAQLLEISRTQVSKQIQ 316275007042 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.9e-40 316275007043 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 316275007044 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 316275007045 Nucleoside recognition; Region: Gate; pfam07670 316275007046 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 316275007047 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 6.6e-32 316275007049 HMMPfam hit to PF07670, Nucleoside recognition,score 3.4e-13 316275007050 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 1.6e-107 316275007051 Uncharacterized conserved protein [Function unknown]; Region: COG1359 316275007052 HMMPfam hit to PF03992, Antibiotic biosynthesis monooxygenase, score 5.7e-17 316275007053 Cupin domain; Region: Cupin_2; cl17218 316275007054 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316275007055 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 316275007056 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316275007057 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 316275007058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 316275007059 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 2.1e-05 316275007060 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 5.1e-08 316275007061 HMMPfam hit to PF00805, Pentapeptide repeats (8 copies), score 3.3e-05 316275007062 protein structure with unknown function; Region: DUF4144; pfam13642 316275007063 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 316275007064 nudix motif; other site 316275007065 HMMPfam hit to PF00293, NUDIX domain, score 2e-11 316275007066 PS00893 mutT domain signature. 316275007067 PGAP1-like protein; Region: PGAP1; pfam07819 316275007068 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007069 PS00120 Lipases, serine active site. 316275007070 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 316275007072 lytic murein transglycosylase; Provisional; Region: PRK11619 316275007073 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275007074 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275007075 catalytic residue [active] 316275007076 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 4.7e-32 316275007077 PS00922 Prokaryotic transglycosylases signature. 316275007079 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 316275007080 Putative catalytic domain of chitin deacetylase-like proteins from insects and similar proteins; Region: CE4_CDA_like; cd10919 316275007081 NodB motif; other site 316275007082 putative active site [active] 316275007083 putative catalytic site [active] 316275007084 putative Zn binding site [ion binding]; other site 316275007085 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 316275007086 aromatic chitin/cellulose binding site residues [chemical binding]; other site 316275007087 HMMPfam hit to PF01522, Polysaccharide deacetylase,score 2.1e-06 316275007088 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 316275007089 HMMPfam hit to PF02839, Carbohydrate binding domain, score 3.4e-07 316275007090 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 316275007092 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275007093 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275007094 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275007095 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E496 (799 aa) fasta scores: E()=5.9e-51, 66.822% id in 214 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275007097 The insertion of the downstream IS element truncates the last 11 amino acid residues of the CDS. There is an inframe translational stop codon one amino acid residue further downstream within the IS element. The truncated CDS may therefore be expressed and functional 316275007098 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275007099 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275007100 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275007102 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 316275007103 HMMPfam hit to PF02112, cAMP phosphodiesterases class-II, score 9.7e-148 316275007104 PS00607 cAMP phosphodiesterases class-II signature. 316275007105 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316275007106 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275007107 DNA binding site [nucleotide binding] 316275007108 domain linker motif; other site 316275007109 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 316275007110 ligand binding site [chemical binding]; other site 316275007111 dimerization interface (closed form) [polypeptide binding]; other site 316275007112 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.4e-12 316275007113 Predicted helix-turn-helix motif with score 1984.000, SD 5.94 at aa 2-23, sequence ATINDVAKLAGVSTATVSRVIN 316275007114 PS00356 Bacterial regulatory proteins, lacI family signature. 316275007115 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 2.6e-08 316275007116 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 316275007118 HMMPfam hit to PF03553, Na+/H+ antiporter family,score 8.8e-82 316275007119 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 316275007120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275007121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275007122 homodimer interface [polypeptide binding]; other site 316275007123 catalytic residue [active] 316275007124 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.4e-30 316275007125 Cupin domain; Region: Cupin_2; cl17218 316275007126 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316275007127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275007128 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 5.4e-12 316275007129 PS00041 Bacterial regulatory proteins, araC family signature. 316275007130 Predicted helix-turn-helix motif with score 1022.000, SD 2.67 at aa 181-202, sequence SSLSVWAKRVFSTERTLARRFQ 316275007131 EamA-like transporter family; Region: EamA; pfam00892 316275007132 EamA-like transporter family; Region: EamA; pfam00892 316275007134 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.4e-22 316275007135 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.4e-20 316275007136 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 316275007137 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 316275007138 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 316275007139 HMMPfam hit to PF01238, Phosphomannose isomerase type I, score 2.4e-48 316275007140 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 316275007141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275007142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275007143 homodimer interface [polypeptide binding]; other site 316275007144 catalytic residue [active] 316275007145 HMMPfam hit to PF00155, Aminotransferase class I and II, score 7.7e-45 316275007146 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 316275007147 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 316275007148 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 316275007149 active site turn [active] 316275007150 phosphorylation site [posttranslational modification] 316275007151 HMMPfam hit to PF00367, phosphotransferase system,EIIB, score 3.2e-16 316275007152 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 316275007154 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 1.3e-103 316275007155 Homeodomain-like domain; Region: HTH_23; cl17451 316275007156 Winged helix-turn helix; Region: HTH_29; pfam13551 316275007157 Homeodomain-like domain; Region: HTH_32; pfam13565 316275007158 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275007159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275007160 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 316275007161 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275007162 DNA binding site [nucleotide binding] 316275007163 domain linker motif; other site 316275007164 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 316275007165 putative dimerization interface [polypeptide binding]; other site 316275007166 putative ligand binding site [chemical binding]; other site 316275007167 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 4e-09 316275007168 Predicted helix-turn-helix motif with score 1702.000, SD 4.98 at aa 6-27, sequence ANIKDVAKRAGVSVTTVSMALS 316275007169 PS00356 Bacterial regulatory proteins, lacI family signature. 316275007170 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1e-40 316275007171 EamA-like transporter family; Region: EamA; pfam00892 316275007172 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316275007173 EamA-like transporter family; Region: EamA; pfam00892 316275007175 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.6e-17 316275007176 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.9e-08 316275007177 Homeodomain-like domain; Region: HTH_23; cl17451 316275007178 Winged helix-turn helix; Region: HTH_29; pfam13551 316275007179 Homeodomain-like domain; Region: HTH_32; pfam13565 316275007180 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275007181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275007182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275007183 HMMPfam hit to PF01476, LysM domain, score 7.2e-13 316275007184 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007185 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 316275007186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 316275007187 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 2.6e-42 316275007188 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 1.7e-06 316275007189 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 316275007190 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 316275007191 conserved cys residue [active] 316275007192 HMMPfam hit to PF01965, DJ-1/PfpI family, score 2.2e-07 316275007193 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 316275007194 putative dimer interface [polypeptide binding]; other site 316275007195 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316275007196 ligand binding site [chemical binding]; other site 316275007197 Zn binding site [ion binding]; other site 316275007198 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.1e-17 316275007199 MltA-interacting protein MipA; Region: MipA; cl01504 316275007200 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 1.4e-35 316275007202 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 316275007203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275007204 FeS/SAM binding site; other site 316275007205 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 316275007206 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.1e-08 316275007207 PS00190 Cytochrome c family heme-binding site signature. 316275007208 Similar to Nitrosococcus oceani Glycosyl transferase, family 2 UniProt:Q3JDI9 (244 aa) fasta scores: E()=2.7e-43, 54.338% id in 219 aa. CDS contains a frameshift after codon 108. The sequence has been checked and is believed to be correct 316275007209 HMMPfam hit to PF00535, Glycosyl transferase family, score 4.9e-13 316275007210 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 316275007211 Similar to Hahella chejuensis Na+/proline symporter UniProt:Q2S7Q2 (467 aa) fasta scores: E()=5.9e-65, 50.694% id in 432 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275007213 HMMPfam hit to PF00474, Sodium:solute symporter family, score 0.0013 316275007214 Homeodomain-like domain; Region: HTH_23; cl17451 316275007215 Winged helix-turn helix; Region: HTH_29; pfam13551 316275007216 Homeodomain-like domain; Region: HTH_32; pfam13565 316275007217 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275007218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275007219 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316275007220 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 316275007221 Phosphotransferase enzyme family; Region: APH; pfam01636 316275007222 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275007223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275007224 dimer interface [polypeptide binding]; other site 316275007225 putative CheW interface [polypeptide binding]; other site 316275007226 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 5.5e-41 316275007228 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275007229 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275007230 Integrase core domain; Region: rve; pfam00665 316275007231 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 24-45, sequence ISAREIGQKLKRSNGSISKELR 316275007232 HMMPfam hit to PF00665, Integrase core domain,score 1.1e-31 316275007233 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 316275007234 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 316275007235 Protein of unknown function (DUF497); Region: DUF497; cl01108 316275007236 HMMPfam hit to PF04365, Protein of unknown function (DUF497), score 3.4e-38 316275007237 Predicted transcriptional regulator [Transcription]; Region: COG2944 316275007238 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 316275007239 non-specific DNA binding site [nucleotide binding]; other site 316275007240 salt bridge; other site 316275007241 sequence-specific DNA binding site [nucleotide binding]; other site 316275007242 Predicted helix-turn-helix motif with score 1492.000, SD 4.27 at aa 54-75, sequence MSRGVFAHLLHTSSRTLENWEQ 316275007243 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 316275007247 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 316275007248 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275007249 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275007250 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275007251 Similar to N-terminal part of Vibrio anguillarum JM19 Transposase UniProt:Q48354 (302 aa) fasta scores: E()=1.1e-10, 75.556% id in 45 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events. CDS also seems to be truncated in the C-terminal part by the insertion of the downstream IS element 316275007252 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007254 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275007255 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007256 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275007257 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275007258 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275007259 Similar to Bacillus subtilis Lichenan permease IIC component LicC UniProt:P46317 (452 aa) fasta scores: E()=9.8e-48, 43.400% id in 447 aa. CDS contains a frameshift after codon 115. The sequence has been checked and is believed to be correct 316275007260 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 1.3e-75 316275007262 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 316275007263 active site 316275007264 dimer interface [polypeptide binding]; other site 316275007265 catalytic nucleophile [active] 316275007266 HMMPfam hit to PF01112, Asparaginase, score 3.6e-53 316275007267 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 316275007268 active site 316275007269 P-loop; other site 316275007270 phosphorylation site [posttranslational modification] 316275007271 HMMPfam hit to PF02302, PTS system,Lactose/Cellobiose specific IIB, score 1e-28 316275007272 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 316275007273 methionine cluster; other site 316275007274 active site 316275007275 phosphorylation site [posttranslational modification] 316275007276 metal binding site [ion binding]; metal-binding site 316275007277 HMMPfam hit to PF02255, PTS system,Lactose/Cellobiose specific IIA, score 6.6e-30 316275007278 Similar to C-terminal part of Photobacterium sp. transcriptional regulator UniProt:Q2C9E4 (279 aa) fasta scores: E()=7.9e-06, 50.000% id in 64 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275007279 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007281 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275007282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007283 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275007284 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275007285 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275007286 Protein of unknown function (DUF3081); Region: DUF3081; pfam11280 316275007287 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 316275007289 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 316275007290 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 316275007291 putative dimer interface [polypeptide binding]; other site 316275007292 HMMPfam hit to PF00011, Hsp20/alpha crystallin family, score 3.7e-16 316275007293 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 316275007294 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 316275007295 nucleotide binding site [chemical binding]; other site 316275007296 HMMPfam hit to PF00012, Hsp70 protein, score 0 316275007297 PS00297 Heat shock hsp70 proteins family signature 1. 316275007298 PS00329 Heat shock hsp70 proteins family signature 2. 316275007299 PS01036 Heat shock hsp70 proteins family signature 3. 316275007300 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007302 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275007303 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007304 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275007305 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275007306 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275007307 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316275007308 endonuclease III; Region: ENDO3c; smart00478 316275007309 minor groove reading motif; other site 316275007310 helix-hairpin-helix signature motif; other site 316275007311 substrate binding pocket [chemical binding]; other site 316275007312 active site 316275007313 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 1.5e-20 316275007314 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316275007315 Sel1-like repeats; Region: SEL1; smart00671 316275007316 Sel1-like repeats; Region: SEL1; smart00671 316275007317 Sel1-like repeats; Region: SEL1; smart00671 316275007318 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316275007319 HSP70 interaction site [polypeptide binding]; other site 316275007320 HMMPfam hit to PF08238, Sel1 repeat, score 9.2e-07 316275007321 HMMPfam hit to PF08238, Sel1 repeat, score 4.1e-11 316275007322 HMMPfam hit to PF08238, Sel1 repeat, score 0.00014 316275007324 HMMPfam hit to PF00226, DnaJ domain, score 4.7e-06 316275007325 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 316275007326 amphipathic channel; other site 316275007327 Asn-Pro-Ala signature motifs; other site 316275007329 HMMPfam hit to PF00230, Major intrinsic protein,score 1.1e-48 316275007330 PS00221 MIP family signature. 316275007331 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007333 Similar to Vibrio parahaemolyticus Hypothetical protein VPA1572 UniProt:Q87FV6 (368 aa) fasta scores: E()=1.1e-89, 72.099% id in 362 aa. CDS contains a nonsense mutation (CAA to TAA) after codon 78. The sequence has been checked and is believed to be correct 316275007334 HMMPfam hit to PF04313, Type I restriction enzyme R protein N termin, score 1.8e-19 316275007335 exonuclease I; Provisional; Region: sbcB; PRK11779 316275007336 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 316275007337 active site 316275007338 catalytic site [active] 316275007339 substrate binding site [chemical binding]; other site 316275007340 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 316275007341 HMMPfam hit to PF00929, Exonuclease, score 1.8e-29 316275007342 HMMPfam hit to PF08411, Exonuclease C-terminal,score 1.6e-164 316275007343 LrgA family; Region: LrgA; cl00608 316275007344 HMMPfam hit to PF03788, LrgA family, score 9.5e-30 316275007346 Similar to N-terminal of Vibrio fischeri Murein hydrolase export regulator UniProt:Q5E4R7 (224 aa) fasta scores: E()=3.6e-12, 85.000% id in 40 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275007347 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275007348 Putative transposase; Region: Y2_Tnp; pfam04986 316275007349 cytidine deaminase; Provisional; Region: PRK09027 316275007350 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 316275007351 active site 316275007352 catalytic motif [active] 316275007353 Zn binding site [ion binding]; other site 316275007354 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 316275007355 active site 316275007356 catalytic motif [active] 316275007357 Zn binding site [ion binding]; other site 316275007358 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 9.3e-15 316275007360 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 316275007361 HMMPfam hit to PF08211, Cytidine and deoxycytidylate deaminas, score 1.1e-61 316275007362 Amidase; Region: Amidase; cl11426 316275007363 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 316275007364 HMMPfam hit to PF01425, Amidase, score 5.8e-11 316275007365 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275007366 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007367 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 316275007368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275007369 ATP-grasp domain; Region: ATP-grasp; pfam02222 316275007370 HMMPfam hit to PF02222, ATP-grasp domain, score 2.6e-92 316275007371 HMMPfam hit to PF02655, ATP-grasp domain, score 0.0041 316275007372 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP, score 0.00028 316275007373 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 316275007374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275007375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275007376 homodimer interface [polypeptide binding]; other site 316275007377 catalytic residue [active] 316275007378 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.7e-111 316275007379 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 316275007380 Methyltransferase domain; Region: Methyltransf_32; pfam13679 316275007381 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 316275007382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275007383 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 316275007384 substrate binding site [chemical binding]; other site 316275007385 dimerization interface [polypeptide binding]; other site 316275007386 HMMPfam hit to PF03466, LysR substrate binding domain, score 4e-40 316275007387 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 316275007388 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.5e-16 316275007389 PS00044 Bacterial regulatory proteins, lysR family signature. 316275007390 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 17-38, sequence LNVSSTAESLYTSQPGISKQVR 316275007394 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275007395 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275007396 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275007397 acetyl-CoA decarbonylase/synthase complex subunit alpha; Validated; Region: PRK00941 316275007398 Protein of unknown function (DUF342); Region: DUF342; pfam03961 316275007399 HMMPfam hit to PF03961, Protein of unknown function (DUF342), score 1.6e-96 316275007400 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 316275007401 GSH binding site [chemical binding]; other site 316275007402 catalytic residues [active] 316275007403 HMMPfam hit to PF00462, Glutaredoxin, score 2.1e-14 316275007404 hypothetical protein; Provisional; Region: PRK10626 316275007405 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 316275007406 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 316275007407 ATP binding site [chemical binding]; other site 316275007408 active site 316275007409 substrate binding site [chemical binding]; other site 316275007410 HMMPfam hit to PF01259, SAICAR synthetase, score 1.4e-14 316275007411 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 316275007412 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 1.4e-08 316275007414 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 316275007415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275007416 ATP binding site [chemical binding]; other site 316275007417 putative Mg++ binding site [ion binding]; other site 316275007418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275007419 nucleotide binding region [chemical binding]; other site 316275007420 ATP-binding site [chemical binding]; other site 316275007421 Helicase associated domain (HA2); Region: HA2; pfam04408 316275007422 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 316275007423 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 316275007424 HMMPfam hit to PF07717, Domain of unknown function (DUF1605), score 2.8e-19 316275007425 HMMPfam hit to PF04408, Helicase associated domain (HA2), score 1e-25 316275007426 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.4e-10 316275007427 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007428 outer membrane protein A; Reviewed; Region: PRK10808 316275007429 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 316275007430 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275007431 ligand binding site [chemical binding]; other site 316275007432 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 3.7e-11 316275007433 HMMPfam hit to PF00691, OmpA family, score 1.9e-25 316275007434 PS01068 OmpA-like domain. 316275007435 CDS is truncated by the insertion of the downstream IS element. There is an inframe translational stop codon 2 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275007436 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007437 PS00018 EF-hand calcium-binding domain. 316275007438 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275007439 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275007440 HMMPfam hit to PF01609, Transposase DDE domain,score 5.8e-28 316275007441 CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275007442 PS00560 Serine carboxypeptidases, histidine active site. 316275007443 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 316275007444 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 316275007445 HMMPfam hit to PF04358, DsrC like protein, score 3.4e-70 316275007446 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 316275007447 acylphosphatase; Provisional; Region: PRK14426 316275007448 HMMPfam hit to PF00708, Acylphosphatase, score 5.1e-12 316275007449 PS00151 Acylphosphatase signature 2. 316275007450 PS00150 Acylphosphatase signature 1. 316275007451 Similar to N-terminal part of Vibrio fischeri Methyl-accepting chemotaxis protein UniProt:Q5E4P8 (467 aa) fasta scores: E()=6.5e-23, 70.175% id in 114 aa. CDS is disrupted by the insertion of an IS element after codon 99 and appears to be truncated at the C-terminus 316275007453 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275007454 Putative transposase; Region: Y2_Tnp; pfam04986 316275007455 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 316275007456 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 316275007457 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 316275007458 putative RNA binding site [nucleotide binding]; other site 316275007459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275007460 S-adenosylmethionine binding site [chemical binding]; other site 316275007461 Similar to Vibrio fischeri Iron-regulated protein FrpC UniProt:Q5E4P5 (3971 aa) fasta scores: E()=0, 67.914% id in 4435 aa. CDS contains a frameshift after codon 1038 and a nonsense mutation (TAG) after codon 2383. The sequence has been checked and is believed to be correct 316275007462 PS00044 Bacterial regulatory proteins, lysR family signature. 316275007463 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.079 316275007464 PS00116 DNA polymerase family B signature. 316275007465 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 316275007466 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 316275007467 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 316275007468 active site 316275007469 catalytic site [active] 316275007470 metal binding site [ion binding]; metal-binding site 316275007471 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 1.3e-74 316275007472 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007473 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 316275007474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275007475 putative substrate translocation pore; other site 316275007477 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1e-57 316275007478 PS00018 EF-hand calcium-binding domain. 316275007479 PS00942 glpT family of transporters signature. 316275007480 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007481 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007482 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=7.5e-120, 56.998% id in 493 aa. CDS contains a frameshift after codon 301 316275007483 Similar to Vibrio alginolyticus Hypothetical protein UniProt:Q1V4D4 (148 aa) fasta scores: E()=5.2e-18,56.383% id in 94 aa. CDS seems to be truncated by the insertion of the upstream IS element and subsequent recombination events. CDS is also truncated in the C-terminal end 316275007484 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 316275007485 CDS is possible truncated by the insertion of the downstream IS element and subsequent recombination events 316275007486 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275007487 Putative transposase; Region: Y2_Tnp; pfam04986 316275007488 integrase; Provisional; Region: PRK09692 316275007489 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 316275007490 active site 316275007491 Int/Topo IB signature motif; other site 316275007492 HMMPfam hit to PF00589, Phage integrase family,score 3.1e-20 316275007493 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E5F6 (516 aa) fasta scores: E()=5.9e-140,73.501% id in 517 aa. CDS is disrupted by the insertion of an IS element after codon 299 316275007495 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275007496 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275007497 Integrase core domain; Region: rve; pfam00665 316275007498 HMMPfam hit to PF00665, Integrase core domain,score 1.1e-31 316275007499 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 24-45, sequence ISAREIGQKLKRSNGSISKELR 316275007500 HMMPfam hit to PF00990, GGDEF domain, score 8.5e-38 316275007501 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 316275007502 S1 domain; Region: S1_2; pfam13509 316275007503 PS00659 Glycosyl hydrolases family 5 signature. 316275007505 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316275007506 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 6.2e-08 316275007507 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 316275007508 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 316275007509 HMMPfam hit to PF00793, DAHP synthetase I family,score 4.4e-142 316275007510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 316275007511 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 316275007512 HMMPfam hit to PF04461, Protein of unknown function (DUF520), score 7.1e-97 316275007513 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 316275007514 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 316275007515 active site 316275007516 Zn binding site [ion binding]; other site 316275007517 HMMPfam hit to PF01432, Peptidase family M3, score 1.4e-11 316275007518 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275007519 HMMPfam hit to PF08439, Oligopeptidase F, score 8.5e-15 316275007520 succinylglutamate desuccinylase; Provisional; Region: PRK05324 316275007521 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 316275007522 active site 316275007523 Zn binding site [ion binding]; other site 316275007524 HMMPfam hit to PF04952, Succinylglutamate desuccinylase / Aspartoac, score 6.9e-45 316275007525 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316275007526 IHF dimer interface [polypeptide binding]; other site 316275007527 IHF - DNA interface [nucleotide binding]; other site 316275007528 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 1.9e-46 316275007529 PS00045 Bacterial histone-like DNA-binding proteins signature. 316275007530 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 316275007531 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 316275007532 putative tRNA-binding site [nucleotide binding]; other site 316275007533 B3/4 domain; Region: B3_4; pfam03483 316275007534 tRNA synthetase B5 domain; Region: B5; smart00874 316275007535 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 316275007536 dimer interface [polypeptide binding]; other site 316275007537 motif 1; other site 316275007538 motif 3; other site 316275007539 motif 2; other site 316275007540 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 316275007541 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 2.6e-38 316275007542 HMMPfam hit to PF03484, tRNA synthetase B5 domain,score 6.5e-28 316275007543 HMMPfam hit to PF03483, B3/4 domain, score 6.7e-107 316275007544 HMMPfam hit to PF01588, tRNA binding domain, score 4.4e-41 316275007545 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 316275007546 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 316275007547 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 316275007548 dimer interface [polypeptide binding]; other site 316275007549 motif 1; other site 316275007550 active site 316275007551 motif 2; other site 316275007552 motif 3; other site 316275007553 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 1.1e-161 316275007554 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275007555 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275007556 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 4.2e-33 316275007557 Similar to Vibrio anguillarum HuvS protein UniProt:Q2WCM6 (719 aa) fasta scores: E()=2.5e-125,59.341% id in 728 aa. CDS contains a frameshift after codon 5. The sequence has been checked and is believed to be correct 316275007558 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 2.8e-28 316275007559 HMMPfam hit to PF00593, TonB dependent receptor,score 1.1e-24 316275007560 Similar to N-terminal part of Vibrio fischeri Hypothetical protein UniProt:Q5E5G8 (237 aa) fasta scores: E()=3.4e-27, 96.154% id in 78 aa. The CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275007562 Homeodomain-like domain; Region: HTH_23; cl17451 316275007563 Winged helix-turn helix; Region: HTH_29; pfam13551 316275007564 Homeodomain-like domain; Region: HTH_32; pfam13565 316275007565 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275007566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275007567 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E5G9 (243 aa) fasta scores: E()=1.8e-56, 79.581% id in 191 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275007572 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E5H0 (1086 aa) fasta scores: E()=2.5e-146,44.529% id in 1051 aa. CDS contains a nonsense mutation (TAA) after codon 871. The sequence has been checked and is believed to be correct 316275007574 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 316275007575 HMMPfam hit to PF04524, Protein of unknown function, DUF586, score 2.4e-48 316275007576 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007578 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275007579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007580 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275007581 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275007582 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275007583 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 316275007584 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 316275007585 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 2.9e-23 316275007586 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 316275007587 HMMPfam hit to PF06228, Protein of unknown function (DUF1008), score 7.7e-75 316275007588 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 316275007589 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275007590 FeS/SAM binding site; other site 316275007591 HMMPfam hit to PF06969, HemN C-terminal region,score 8.6e-05 316275007592 HMMPfam hit to PF04055, Radical SAM superfamily,score 5.3e-18 316275007593 Similar to Listonella anguillarum serovar O1 TonB protein UniProt:Q70YH2 (240 aa) fasta scores: E()=5e-33,45.000% id in 240 aa. CDS contains a frameshift after codon 73. The sequence has been checked and is believed to be correct 316275007595 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 316275007597 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 7.4e-09 316275007598 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 316275007599 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 316275007600 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 3.4e-29 316275007602 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 316275007603 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 316275007604 HMMPfam hit to PF01497, Periplasmic binding protein, score 7.3e-45 316275007605 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 316275007606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275007607 ABC-ATPase subunit interface; other site 316275007608 dimer interface [polypeptide binding]; other site 316275007609 putative PBP binding regions; other site 316275007610 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 316275007612 HMMPfam hit to PF01032, FecCD transport family,score 1.8e-106 316275007613 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 316275007614 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316275007615 Walker A/P-loop; other site 316275007616 ATP binding site [chemical binding]; other site 316275007617 Q-loop/lid; other site 316275007618 ABC transporter signature motif; other site 316275007619 Walker B; other site 316275007620 D-loop; other site 316275007621 H-loop/switch region; other site 316275007622 HMMPfam hit to PF00005, ABC transporter score 2e-44 316275007623 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007624 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 316275007625 23S rRNA binding site [nucleotide binding]; other site 316275007626 L21 binding site [polypeptide binding]; other site 316275007627 L13 binding site [polypeptide binding]; other site 316275007628 HMMPfam hit to PF00453, Ribosomal protein L20,score 2e-65 316275007629 PS00937 Ribosomal protein L20 signature. 316275007630 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 316275007631 HMMPfam hit to PF01632, Ribosomal protein L35,score 3.2e-26 316275007632 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 316275007633 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 316275007634 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 316275007635 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 2.5e-53 316275007636 HMMPfam hit to PF05198, Translation initiation factor IF-3, N-termin, score 1.5e-36 316275007637 PS00938 Initiation factor 3 signature. 316275007638 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 316275007639 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 316275007640 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 316275007641 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 316275007642 active site 316275007643 dimer interface [polypeptide binding]; other site 316275007644 motif 1; other site 316275007645 motif 2; other site 316275007646 motif 3; other site 316275007647 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 316275007648 anticodon binding site; other site 316275007649 HMMPfam hit to PF03129, Anticodon binding domain,score 2.7e-31 316275007650 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275007651 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 2.5e-64 316275007652 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275007653 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase se, score 3.8e-24 316275007654 PS00018 EF-hand calcium-binding domain. 316275007655 HMMPfam hit to PF02824, TGS domain, score 2.8e-15 316275007656 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 316275007657 SpoOM protein; Region: Spo0M; pfam07070 316275007658 HMMPfam hit to PF07070, SpoOM protein, score 1e-50 316275007659 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 316275007660 Peptidase family M50; Region: Peptidase_M50; pfam02163 316275007661 active site 316275007662 putative substrate binding region [chemical binding]; other site 316275007664 HMMPfam hit to PF02163, Peptidase family M50, score 3.9e-32 316275007665 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 316275007666 HMMPfam hit to PF06164, Bacterial protein of unknown function (DUF97, score 1.4e-55 316275007667 putative chaperone; Provisional; Region: PRK11678 316275007668 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 316275007669 nucleotide binding site [chemical binding]; other site 316275007670 putative NEF/HSP70 interaction site [polypeptide binding]; other site 316275007671 SBD interface [polypeptide binding]; other site 316275007672 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007673 PS00329 Heat shock hsp70 proteins family signature 2. 316275007674 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 316275007675 active site 316275007676 HMMPfam hit to PF01569, PAP2 superfamily, score 1.7e-19 316275007678 Protein of unknown function (DUF3581); Region: DUF3581; pfam12119 316275007679 DNA gyrase subunit A; Validated; Region: PRK05560 316275007680 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 316275007681 CAP-like domain; other site 316275007682 active site 316275007683 primary dimer interface [polypeptide binding]; other site 316275007684 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316275007685 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316275007686 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316275007687 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316275007688 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316275007689 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316275007690 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 5e-15 316275007691 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 3.7e-15 316275007692 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 8.4e-15 316275007693 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.5e-10 316275007694 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.8e-13 316275007695 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 8.3e-09 316275007696 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 0 316275007697 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 316275007698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275007699 S-adenosylmethionine binding site [chemical binding]; other site 316275007700 HMMPfam hit to PF02353,Cyclopropane-fatty-acyl-phospholipid, score 0.00041 316275007701 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 0.00019 316275007702 HMMPfam hit to PF08241, Methyltransferase domain,score 1.6e-24 316275007703 HMMPfam hit to PF08242, Methyltransferase domain,score 3.5e-16 316275007704 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 316275007705 ATP cone domain; Region: ATP-cone; pfam03477 316275007706 Class I ribonucleotide reductase; Region: RNR_I; cd01679 316275007707 active site 316275007708 dimer interface [polypeptide binding]; other site 316275007709 catalytic residues [active] 316275007710 effector binding site; other site 316275007711 R2 peptide binding site; other site 316275007712 HMMPfam hit to PF03477, ATP cone domain, score 5.2e-21 316275007713 HMMPfam hit to PF00317, Ribonucleotide reductase,all-alpha d, score 4.9e-21 316275007714 HMMPfam hit to PF02867, Ribonucleotide reductase,barrel doma, score 2.6e-240 316275007715 PS00089 Ribonucleotide reductase large subunit signature. 316275007716 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 316275007717 dimer interface [polypeptide binding]; other site 316275007718 putative radical transfer pathway; other site 316275007719 diiron center [ion binding]; other site 316275007720 tyrosyl radical; other site 316275007721 HMMPfam hit to PF00268, Ribonucleotide reductase,small chain, score 2.9e-08 316275007722 PS00368 Ribonucleotide reductase small subunit signature. 316275007723 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E5K1 (691 aa) fasta scores: E()=1.6e-178,68.622% id in 682 aa. CDS contains a frameshift after codon 159. The sequence has been checked and is believed to be correct 316275007724 PS00430 TonB-dependent receptor proteins signature 1. 316275007725 HMMPfam hit to PF00990, GGDEF domain, score 2e-44 316275007726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316275007727 catalytic loop [active] 316275007728 iron binding site [ion binding]; other site 316275007729 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 9.4e-10 316275007730 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 316275007731 hypothetical protein; Provisional; Region: PRK03673 316275007732 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 316275007733 putative MPT binding site; other site 316275007734 HMMPfam hit to PF00994, molybdopterin binding domain, score 2.1e-41 316275007735 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 316275007736 aromatic amino acid transport protein; Region: araaP; TIGR00837 316275007737 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 1.2e-117 316275007739 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 316275007740 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275007741 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275007742 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275007743 HMMPfam hit to PF01609, Transposase DDE domain,score 7.6e-28 316275007744 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275007745 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275007746 HMMPfam hit to PF01609, Transposase DDE domain,score 0.0055 316275007747 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase. UniProt:Q3IIG2 (EMBL:CR954246) (99 aa) fasta scores: E()=4.3e-06, 31.250% id in 96 aa. CDS contains a frameshift after codon 71 316275007748 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007750 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275007751 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007752 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275007753 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275007754 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275007755 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 316275007756 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 7e-31 316275007757 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 316275007758 HMMPfam hit to PF07433, Protein of unknown function (DUF1513), score 2.1e-146 316275007759 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007760 Imelysin; Region: Peptidase_M75; cl09159 316275007761 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007762 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 316275007763 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 316275007764 HMMPfam hit to PF06537, Protein of unknown function (DUF1111), score 9e-288 316275007765 PS00190 Cytochrome c family heme-binding site signature. 316275007766 PS00190 Cytochrome c family heme-binding site signature. 316275007767 Imelysin; Region: Peptidase_M75; cl09159 316275007768 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 316275007769 dimerization interface [polypeptide binding]; other site 316275007770 active site 316275007771 HMMPfam hit to PF00925, GTP cyclohydrolase II,score 6.2e-78 316275007772 putative alcohol dehydrogenase; Provisional; Region: PRK09860 316275007773 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 316275007774 dimer interface [polypeptide binding]; other site 316275007775 active site 316275007776 metal binding site [ion binding]; metal-binding site 316275007777 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 7.6e-220 316275007778 Predicted helix-turn-helix motif with score 1011.000, SD 2.63 at aa 296-317, sequence ERLKDVAKAMGVNVEGMTNEEG 316275007779 PS00060 Iron-containing alcohol dehydrogenases signature 2. 316275007780 PS00913 Iron-containing alcohol dehydrogenases signature 1. 316275007781 Protein of unknown function DUF45; Region: DUF45; pfam01863 316275007782 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 5.3e-76 316275007783 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275007784 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 316275007785 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 316275007786 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 316275007787 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 316275007788 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 2.1e-17 316275007789 HMMPfam hit to PF04313, Type I restriction enzyme R protein N termin, score 7.8e-50 316275007790 Similar to Shewanella sp. ANA-3 type I restriction-modification system, S subunit UniProt:Q36AA1 (425 aa) fasta scores: E()=1e-35, 36.404% id in 445 aa. CDS contains a nonsense mutation (TAA) after codon 85. The sequence has been checked and is believed to be correct 316275007791 HMMPfam hit to PF01420, Type I restriction modification DNA speci, score 8.2e-12 316275007792 HMMPfam hit to PF01420, Type I restriction modification DNA speci, score 2.6e-09 316275007793 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 316275007794 HsdM N-terminal domain; Region: HsdM_N; pfam12161 316275007795 Methyltransferase domain; Region: Methyltransf_26; pfam13659 316275007796 HMMPfam hit to PF02384, N-6 DNA Methylase, score 1.2e-147 316275007797 PS00092 N-6 Adenine-specific DNA methylases signature. 316275007798 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316275007799 Similar to N-terminal part of Vibrio fischeri Na(+) driven multidrug efflux pump UniProt:Q5E4U9 (489 aa) fasta scores: E()=1.5e-12, 87.805% id in 41 aa. The CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275007801 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007803 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 316275007804 amino acid carrier protein; Region: agcS; TIGR00835 316275007806 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 3.3e-169 316275007807 PS00873 Sodium:alanine symporter family signature. 316275007808 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316275007809 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316275007811 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 2e-69 316275007812 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316275007813 HMMPfam hit to PF01810, LysE type translocator,score 1.1e-32 316275007815 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 316275007816 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 316275007817 active site 316275007818 Zn binding site [ion binding]; other site 316275007819 HMMPfam hit to PF02074, Carboxypeptidase Taq (M32) metallopepti, score 1.6e-135 316275007820 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316275007821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275007822 non-specific DNA binding site [nucleotide binding]; other site 316275007823 salt bridge; other site 316275007824 sequence-specific DNA binding site [nucleotide binding]; other site 316275007825 HMMPfam hit to PF01381, Helix-turn-helix, score 2.2e-11 316275007826 Predicted helix-turn-helix motif with score 2296.000, SD 7.01 at aa 22-43, sequence LTQTELAKKVGVKQSTLSSFEN 316275007827 HipA N-terminal domain; Region: Couple_hipA; pfam13657 316275007828 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 316275007829 HipA-like N-terminal domain; Region: HipA_N; pfam07805 316275007830 HipA-like C-terminal domain; Region: HipA_C; pfam07804 316275007831 HMMPfam hit to PF07805, HipA-like N-terminal domain, score 1.7e-24 316275007832 HMMPfam hit to PF07804, HipA-like C-terminal domain, score 1e-36 316275007833 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 316275007834 active site 316275007835 NTP binding site [chemical binding]; other site 316275007836 metal binding triad [ion binding]; metal-binding site 316275007838 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 316275007839 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 316275007840 HMMPfam hit to PF04244, Deoxyribodipyrimidine photolyase-related pro, score 3.8e-59 316275007841 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 316275007842 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 316275007843 C-terminal domain interface [polypeptide binding]; other site 316275007844 GSH binding site (G-site) [chemical binding]; other site 316275007845 dimer interface [polypeptide binding]; other site 316275007846 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 316275007847 N-terminal domain interface [polypeptide binding]; other site 316275007848 dimer interface [polypeptide binding]; other site 316275007849 substrate binding pocket (H-site) [chemical binding]; other site 316275007850 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 316275007851 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316275007852 NADP binding site [chemical binding]; other site 316275007853 dimer interface [polypeptide binding]; other site 316275007854 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 0.00038 316275007855 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007856 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007857 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007858 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=1.4e-114, 54.8% id in 496 aa. CDS contains a frameshift after codon 308 316275007859 Similar to N-terminal part of Vibrio alginolyticus Methyl-accepting chemotaxis protein UniProt:Q1VE72 (672 aa) fasta scores: E()=9.6e-08, 41.053% id in 95 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275007861 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 316275007862 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 316275007863 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 2.5e-99 316275007865 thiopurine S-methyltransferase; Reviewed; Region: PRK13255 316275007866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316275007867 HMMPfam hit to PF05724, Thiopurine S-methyltransferase (TPMT), score 3.3e-89 316275007868 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316275007869 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 316275007870 active site 316275007871 metal-binding site 316275007872 HMMPfam hit to PF00483, Nucleotidyl transferase,score 5.8e-05 316275007873 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 316275007874 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 0.0015 316275007876 PS00379 CDP-alcohol phosphatidyltransferases signature. 316275007877 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 316275007878 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275007879 catalytic residue [active] 316275007880 HMMPfam hit to PF00266, Aminotransferase class-V,score 1.5e-09 316275007881 Similar to Vibrio fischeri 2',3'-cyclic-nucleotide 2'-phosphodiesterase UniProt:Q5E4P0 (634 aa) fasta scores: E()=4.3e-199, 86.909% id in 634 aa. CDS contains a frameshift after codon 229. The sequence has been checked and is believed to be correct 316275007882 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 3.9e-10 316275007883 PS00786 5'-nucleotidase signature 2. 316275007884 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 1.9e-36 316275007885 outer membrane protein A; Reviewed; Region: PRK10808 316275007886 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 316275007887 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275007888 ligand binding site [chemical binding]; other site 316275007889 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007890 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 5.1e-35 316275007891 HMMPfam hit to PF00691, OmpA family, score 1.5e-31 316275007892 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275007893 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007894 Similar to C-terminal part of Shewanella sp. W3-18-1 Conserved hypothetical ISPpu15, transposase UniProt:Q2WZ77 (263 aa) fasta scores: E()=8.1e-24, 76.829% id in 82 aa. The CDS appears to be truncated at the N-terminus 316275007895 Similar to C-terminal part of Vibrio parahaemolyticus Methyl-accepting chemotaxis protein UniProt:Q87PL6 (531 aa) fasta scores: E()=1.3e-45, 51.342% id in 298 aa. The CDS appears to be truncated at the N-terminus by the insertion of the upstream IS element and subsequent recombination events 316275007896 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.5e-28 316275007897 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 316275007898 active site 316275007899 catalytic site [active] 316275007900 substrate binding site [chemical binding]; other site 316275007901 HMMPfam hit to PF00929, Exonuclease, score 1.8e-10 316275007902 CHASE domain; Region: CHASE; cl01369 316275007903 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275007904 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275007905 metal binding site [ion binding]; metal-binding site 316275007906 active site 316275007907 I-site; other site 316275007908 HMMPfam hit to PF00990, GGDEF domain, score 2.8e-43 316275007910 HMMPfam hit to PF03924, CHASE domain, score 3.6e-22 316275007911 PS00136 Serine proteases, subtilase family,aspartic acid active site. 316275007912 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 316275007914 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 316275007915 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 316275007916 nucleotide binding site [chemical binding]; other site 316275007917 putative NEF/HSP70 interaction site [polypeptide binding]; other site 316275007918 SBD interface [polypeptide binding]; other site 316275007919 PS00297 Heat shock hsp70 proteins family signature 1. 316275007920 PS00329 Heat shock hsp70 proteins family signature 2. 316275007921 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 316275007922 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 316275007923 nucleotide binding site [chemical binding]; other site 316275007924 putative NEF/HSP70 interaction site [polypeptide binding]; other site 316275007925 SBD interface [polypeptide binding]; other site 316275007926 DNA-K related protein; Region: DUF3731; pfam12531 316275007928 Protein of unknown function (DUF2947); Region: DUF2947; pfam11163 316275007929 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 316275007930 uridine phosphorylase; Provisional; Region: PRK11178 316275007931 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 316275007932 HMMPfam hit to PF01048, Phosphorylase family, score 2e-91 316275007933 PS01232 Purine and other phosphorylases family 1 signature. 316275007934 Weakly similar to Vibrio parahaemolyticus biofilm-associated surface protein UniProt:Q87HL0 (2337 aa) fasta scores: E()=1.3e-43, 30.548% id in 1424 aa. CDS may be truncated by the insertion of the downstream IS element and subsequent recombination events 316275007935 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007936 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.5e-103, 52.535% id in 493 aa. CDS contains several frameshifts 316275007937 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275007938 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275007939 Similar to Pseudoalteromonas haloplanktis transposase UniProt:Q3IIG1 (99 aa) fasta scores: E()=0.00016, 30.9% id in 97 aa. CDS contains a frameshift after codon 56 316275007940 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 316275007941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275007942 Walker A/P-loop; other site 316275007943 ATP binding site [chemical binding]; other site 316275007944 Q-loop/lid; other site 316275007945 ABC transporter signature motif; other site 316275007946 Walker B; other site 316275007947 D-loop; other site 316275007948 H-loop/switch region; other site 316275007949 HMMPfam hit to PF00005, ABC transporter score 5.1e-54 316275007950 PS00211 ABC transporters family signature. 316275007951 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007953 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 316275007954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316275007955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275007956 Walker A/P-loop; other site 316275007957 ATP binding site [chemical binding]; other site 316275007958 Q-loop/lid; other site 316275007959 ABC transporter signature motif; other site 316275007960 Walker B; other site 316275007961 D-loop; other site 316275007962 H-loop/switch region; other site 316275007963 HMMPfam hit to PF00005, ABC transporter score 4.8e-56 316275007964 PS00211 ABC transporters family signature. 316275007965 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007967 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 1.9e-41 316275007968 thioredoxin reductase; Provisional; Region: PRK10262 316275007969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275007970 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275007971 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 3.5e-47 316275007972 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 1.9e-20 316275007973 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 316275007974 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 316275007975 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 316275007976 hexamer interface [polypeptide binding]; other site 316275007977 ligand binding site [chemical binding]; other site 316275007978 putative active site [active] 316275007979 NAD(P) binding site [chemical binding]; other site 316275007980 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT,C-terminal do, score 1.7e-85 316275007981 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 0.0044 316275007982 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 7.6e-05 316275007983 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT,N-terminal do, score 9.7e-75 316275007984 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 316275007985 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275007986 putative DNA binding site [nucleotide binding]; other site 316275007987 putative Zn2+ binding site [ion binding]; other site 316275007988 AsnC family; Region: AsnC_trans_reg; pfam01037 316275007989 PS00519 Bacterial regulatory proteins, asnC family signature. 316275007990 HMMPfam hit to PF01037, AsnC family, score 1.9e-27 316275007991 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 316275007992 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 316275007993 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 316275007995 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 9.4e-89 316275007996 PS00017 ATP/GTP-binding site motif A (P-loop). 316275007997 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 316275007998 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 316275007999 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein L, score 2.1e-60 316275008000 recombination factor protein RarA; Reviewed; Region: PRK13342 316275008001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275008002 Walker A motif; other site 316275008003 ATP binding site [chemical binding]; other site 316275008004 Walker B motif; other site 316275008005 arginine finger; other site 316275008006 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 316275008007 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 7.8e-22 316275008008 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008009 seryl-tRNA synthetase; Provisional; Region: PRK05431 316275008010 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 316275008011 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 316275008012 dimer interface [polypeptide binding]; other site 316275008013 active site 316275008014 motif 1; other site 316275008015 motif 2; other site 316275008016 motif 3; other site 316275008017 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 1.6e-41 316275008018 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 1.2e-64 316275008019 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275008020 thioredoxin 2; Provisional; Region: PRK10996 316275008021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 316275008022 catalytic residues [active] 316275008023 HMMPfam hit to PF00085, Thioredoxin, score 1.3e-25 316275008024 dsDNA-mimic protein; Reviewed; Region: PRK05094 316275008025 HMMPfam hit to PF04269, Protein of unknown function, DUF440, score 2.1e-70 316275008026 inosine/guanosine kinase; Provisional; Region: PRK15074 316275008027 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316275008028 substrate binding site [chemical binding]; other site 316275008029 ATP binding site [chemical binding]; other site 316275008030 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 6.7e-14 316275008031 PS00584 pfkB family of carbohydrate kinases signature 2. 316275008032 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 316275008033 active site 316275008034 phosphate binding residues; other site 316275008035 catalytic residues [active] 316275008036 HMMPfam hit to PF01263, Aldose 1-epimerase, score 8.8e-46 316275008037 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 316275008038 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 316275008039 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316275008040 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 4.3e-104 316275008041 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 316275008042 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 1.1e-91 316275008043 methionine sulfoxide reductase B; Provisional; Region: PRK00222 316275008044 SelR domain; Region: SelR; pfam01641 316275008045 HMMPfam hit to PF01641, SelR domain, score 1.7e-70 316275008046 Protein of unknown function (DUF2989); Region: DUF2989; pfam11207 316275008048 Protein of unknown function (DUF1315); Region: DUF1315; pfam07023 316275008049 HMMPfam hit to PF07023, Protein of unknown function (DUF1315), score 2e-54 316275008051 Ion transport protein; Region: Ion_trans; pfam00520 316275008052 Ion channel; Region: Ion_trans_2; pfam07885 316275008053 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 316275008054 HMMPfam hit to PF07885, Ion channel, score 2.8e-18 316275008056 HMMPfam hit to PF00520, Ion transport protein,score 2.1e-37 316275008057 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 316275008058 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 316275008059 putative catalytic cysteine [active] 316275008060 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 316275008061 putative active site [active] 316275008062 metal binding site [ion binding]; metal-binding site 316275008063 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.2e-08 316275008064 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.4e-193 316275008065 PS00913 Iron-containing alcohol dehydrogenases signature 1. 316275008066 PS00060 Iron-containing alcohol dehydrogenases signature 2. 316275008067 short chain dehydrogenase; Provisional; Region: PRK08862 316275008068 classical (c) SDRs; Region: SDR_c; cd05233 316275008069 NAD(P) binding site [chemical binding]; other site 316275008070 active site 316275008071 Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993 316275008072 superoxide dismutase; Provisional; Region: PRK10543 316275008073 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 316275008074 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 316275008075 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 2.3e-67 316275008076 PS00088 Manganese and iron superoxide dismutases signature. 316275008077 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 1.3e-50 316275008078 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008079 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 316275008080 putative GSH binding site [chemical binding]; other site 316275008081 catalytic residues [active] 316275008082 HMMPfam hit to PF00462, Glutaredoxin, score 2.3e-23 316275008083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275008084 Response regulator receiver domain; Region: Response_reg; pfam00072 316275008085 active site 316275008086 phosphorylation site [posttranslational modification] 316275008087 intermolecular recognition site; other site 316275008088 dimerization interface [polypeptide binding]; other site 316275008089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275008090 binding surface 316275008091 TPR motif; other site 316275008092 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008093 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.7e-14 316275008094 Predicted permease [General function prediction only]; Region: COG2056 316275008095 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 316275008096 HMMPfam hit to PF06808, DctM-like transporters,score 0.0022 316275008098 HMMPfam hit to PF03553, Na+/H+ antiporter family,score 2.9e-95 316275008099 HMMPfam hit to PF03600, Citrate transporter score 8.4e-05 316275008100 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 316275008101 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 316275008102 dimer interface [polypeptide binding]; other site 316275008103 catalytic site [active] 316275008104 putative active site [active] 316275008105 putative substrate binding site [chemical binding]; other site 316275008106 HMMPfam hit to PF00929, Exonuclease, score 7.6e-35 316275008107 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316275008108 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275008109 ligand binding site [chemical binding]; other site 316275008110 HMMPfam hit to PF00691, OmpA family, score 2.9e-31 316275008111 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 316275008112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316275008113 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 316275008114 dimer interface [polypeptide binding]; other site 316275008115 active site 316275008116 metal binding site [ion binding]; metal-binding site 316275008117 glutathione binding site [chemical binding]; other site 316275008118 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 9.8e-41 316275008119 PS00935 Glyoxalase I signature 2. 316275008120 PS00934 Glyoxalase I signature 1. 316275008121 endonuclease III; Provisional; Region: PRK10702 316275008122 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 316275008123 minor groove reading motif; other site 316275008124 helix-hairpin-helix signature motif; other site 316275008125 substrate binding pocket [chemical binding]; other site 316275008126 active site 316275008127 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 316275008128 PS00764 Endonuclease III iron-sulfur binding region signature. 316275008129 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 4e-16 316275008130 PS01155 Endonuclease III family signature. 316275008131 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 0.00034 316275008132 electron transport complex RsxE subunit; Provisional; Region: PRK12405 316275008134 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 1.3e-106 316275008135 electron transport complex protein RnfG; Validated; Region: PRK01908 316275008136 HMMPfam hit to PF04205, FMN-binding domain, score 1e-23 316275008138 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 316275008139 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family,score 1.7e-143 316275008141 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 316275008142 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 316275008143 SLBB domain; Region: SLBB; pfam10531 316275008144 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 316275008145 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 7.5e-05 316275008146 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275008147 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0015 316275008148 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275008149 HMMPfam hit to PF01512, Respiratory-chain NADH dehydrogenase, score 4.5e-58 316275008150 electron transport complex protein RnfB; Provisional; Region: PRK05113 316275008151 Putative Fe-S cluster; Region: FeS; pfam04060 316275008152 4Fe-4S binding domain; Region: Fer4; pfam00037 316275008153 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 5.1e-05 316275008154 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275008155 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 2.5e-07 316275008156 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275008157 HMMPfam hit to PF04060, Fe-S cluster,score 4.8e-17 316275008159 electron transport complex protein RsxA; Provisional; Region: PRK05151 316275008160 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 5.6e-104 316275008162 excinuclease ABC subunit B; Provisional; Region: PRK05298 316275008163 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275008164 ATP binding site [chemical binding]; other site 316275008165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275008166 nucleotide binding region [chemical binding]; other site 316275008167 ATP-binding site [chemical binding]; other site 316275008168 Ultra-violet resistance protein B; Region: UvrB; pfam12344 316275008169 UvrB/uvrC motif; Region: UVR; pfam02151 316275008170 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008171 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.9e-20 316275008172 HMMPfam hit to PF02151, UvrB/uvrC motif, score 8.4e-12 316275008173 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316275008174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275008175 active site 316275008176 phosphorylation site [posttranslational modification] 316275008177 intermolecular recognition site; other site 316275008178 dimerization interface [polypeptide binding]; other site 316275008179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275008180 Walker A motif; other site 316275008181 ATP binding site [chemical binding]; other site 316275008182 Walker B motif; other site 316275008183 arginine finger; other site 316275008184 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316275008185 HMMPfam hit to PF00072, Response regulator receiver domain, score 2e-31 316275008186 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 6.6e-140 316275008187 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275008188 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 8e-10 316275008189 Predicted helix-turn-helix motif with score 2045.000, SD 6.15 at aa 443-464, sequence GNIPRAAKQLEVSPSTIYRKLQ 316275008190 Hpt domain; Region: Hpt; pfam01627 316275008191 putative binding surface; other site 316275008192 active site 316275008193 HMMPfam hit to PF01627, Hpt domain, score 6.6e-10 316275008194 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 316275008195 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 316275008196 phosphate binding site [ion binding]; other site 316275008197 putative substrate binding pocket [chemical binding]; other site 316275008198 dimer interface [polypeptide binding]; other site 316275008199 HMMPfam hit to PF01933, Uncharacterised protein family UPF0052, score 9.7e-102 316275008200 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 316275008201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275008202 FeS/SAM binding site; other site 316275008203 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 316275008204 HMMPfam hit to PF04055, Radical SAM superfamily,score 1.6e-35 316275008205 HMMPfam hit to PF06463, Molybdenum Cofactor Synthesis C, score 1.1e-44 316275008206 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 316275008207 trimer interface [polypeptide binding]; other site 316275008208 dimer interface [polypeptide binding]; other site 316275008209 putative active site [active] 316275008210 HMMPfam hit to PF01967, MoaC family, score 6e-91 316275008211 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 316275008212 MoaE interaction surface [polypeptide binding]; other site 316275008213 MoeB interaction surface [polypeptide binding]; other site 316275008214 thiocarboxylated glycine; other site 316275008215 HMMPfam hit to PF02597, ThiS family, score 2.7e-21 316275008216 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 316275008217 MoaE homodimer interface [polypeptide binding]; other site 316275008218 MoaD interaction [polypeptide binding]; other site 316275008219 active site residues [active] 316275008220 HMMPfam hit to PF02391, MoaE protein, score 1.1e-46 316275008221 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 316275008222 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 316275008223 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 316275008224 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 316275008226 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275008227 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 316275008228 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 316275008229 HMMPfam hit to PF05618, Protein of unknown function (DUF785), score 1.2e-57 316275008230 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275008231 Methyltransferase domain; Region: Methyltransf_23; pfam13489 316275008232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275008233 S-adenosylmethionine binding site [chemical binding]; other site 316275008234 HMMPfam hit to PF08003, Protein of unknown function (DUF1698), score 1.1e-243 316275008235 HMMPfam hit to PF08241, Methyltransferase domain,score 1.9e-07 316275008236 HMMPfam hit to PF08242, Methyltransferase domain,score 1.1e-05 316275008237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275008238 S-adenosylmethionine binding site [chemical binding]; other site 316275008239 HMMPfam hit to PF08241, Methyltransferase domain,score 2.8e-13 316275008240 HMMPfam hit to PF08242, Methyltransferase domain,score 6.1e-14 316275008241 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 316275008242 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 316275008243 dimer interface [polypeptide binding]; other site 316275008244 anticodon binding site; other site 316275008245 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 316275008246 homodimer interface [polypeptide binding]; other site 316275008247 motif 1; other site 316275008248 active site 316275008249 motif 2; other site 316275008250 GAD domain; Region: GAD; pfam02938 316275008251 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316275008252 active site 316275008253 motif 3; other site 316275008254 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 3.8e-26 316275008255 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 3.5e-207 316275008256 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275008257 HMMPfam hit to PF02938, GAD domain, score 5.2e-48 316275008258 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275008259 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 316275008260 active site 316275008261 putative DNA-binding cleft [nucleotide binding]; other site 316275008262 dimer interface [polypeptide binding]; other site 316275008263 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 2.5e-89 316275008264 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 316275008265 RuvA N terminal domain; Region: RuvA_N; pfam01330 316275008266 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 316275008267 HMMPfam hit to PF01330, RuvA N terminal domain,score 1.3e-27 316275008268 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 0.0016 316275008269 HMMPfam hit to PF07499, RuvA, C-terminal domain,score 8.2e-20 316275008270 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 316275008271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275008272 Walker A motif; other site 316275008273 ATP binding site [chemical binding]; other site 316275008274 Walker B motif; other site 316275008275 arginine finger; other site 316275008276 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 316275008277 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 1.1e-25 316275008278 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.5e-32 316275008279 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.1e-05 316275008280 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008281 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 1.1e-52 316275008282 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 316275008283 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 316275008284 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 0 316275008286 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 316275008287 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 316275008288 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 2.2e-189 316275008290 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 316275008291 HMMPfam hit to PF08173, Membrane bound YbgT-like protein, score 3.5e-16 316275008293 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 316275008295 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316275008296 active site 316275008297 HMMPfam hit to PF03061, Thioesterase superfamily,score 7.8e-16 316275008298 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 316275008300 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 6.4e-57 316275008301 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 316275008302 TolR protein; Region: tolR; TIGR02801 316275008303 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 1.1e-16 316275008305 TolA protein; Region: tolA_full; TIGR02794 316275008306 TolA C-terminal; Region: TolA; pfam06519 316275008307 HMMPfam hit to PF06519, TolA protein, score 4.4e-77 316275008309 translocation protein TolB; Provisional; Region: tolB; PRK04792 316275008310 TolB amino-terminal domain; Region: TolB_N; pfam04052 316275008311 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316275008312 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316275008313 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 316275008314 HMMPfam hit to PF04052, TolB amino-terminal domain,score 9.6e-73 316275008315 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008316 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 4.8e-06 316275008317 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.23 316275008318 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 3.2e-09 316275008319 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275008320 ligand binding site [chemical binding]; other site 316275008321 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275008322 HMMPfam hit to PF00691, OmpA family, score 1.4e-44 316275008323 PS01068 OmpA-like domain. 316275008324 PS00211 ABC transporters family signature. 316275008325 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316275008326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275008327 binding surface 316275008328 TPR motif; other site 316275008329 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 9.9e-05 316275008330 quinolinate synthetase; Provisional; Region: PRK09375 316275008331 HMMPfam hit to PF02445, Quinolinate synthetase A protein, score 8.5e-168 316275008333 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 316275008334 Helix-turn-helix domain; Region: HTH_18; pfam12833 316275008335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275008336 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.6e-08 316275008337 Predicted helix-turn-helix motif with score 1502.000, SD 4.30 at aa 271-292, sequence LSITQAAKLLQMTTRTFQRRLK 316275008338 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 316275008339 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275008340 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275008342 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.7e-25 316275008343 PS00761 Signal peptidases I signature 3. 316275008344 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 316275008346 PS00012 Phosphopantetheine attachment site. 316275008347 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 316275008348 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 1.4e-16 316275008350 Ion channel; Region: Ion_trans_2; pfam07885 316275008352 HMMPfam hit to PF00520, Ion transport protein,score 0.012 316275008353 HMMPfam hit to PF07885, Ion channel, score 4.5e-10 316275008354 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 316275008355 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 316275008356 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 316275008357 HMMPfam hit to PF06610, Protein of unknown function (DUF1144), score 3.9e-71 316275008360 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 3.6e-55 316275008361 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 3.1e-80 316275008362 Homeodomain-like domain; Region: HTH_23; cl17451 316275008363 Winged helix-turn helix; Region: HTH_29; pfam13551 316275008364 Homeodomain-like domain; Region: HTH_32; pfam13565 316275008365 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275008366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275008367 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 316275008369 ACT domain; Region: ACT_3; pfam10000 316275008370 Family description; Region: ACT_7; pfam13840 316275008371 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 316275008372 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 316275008373 HflX GTPase family; Region: HflX; cd01878 316275008374 G1 box; other site 316275008375 GTP/Mg2+ binding site [chemical binding]; other site 316275008376 Switch I region; other site 316275008377 G2 box; other site 316275008378 G3 box; other site 316275008379 Switch II region; other site 316275008380 G4 box; other site 316275008381 G5 box; other site 316275008382 HMMPfam hit to PF01926, GTPase of unknown function,score 7.6e-33 316275008383 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275008385 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316275008386 Coenzyme A binding pocket [chemical binding]; other site 316275008387 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 9.8e-14 316275008388 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316275008389 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 316275008390 NADP binding site [chemical binding]; other site 316275008391 dimer interface [polypeptide binding]; other site 316275008392 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 4.4e-13 316275008393 putative MFS family transporter protein; Provisional; Region: PRK03633 316275008394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275008396 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.3e-24 316275008398 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316275008400 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.7e-06 316275008401 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 7.4e-05 316275008402 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 316275008404 Similar to Vibrio alginolyticus 12g01 outer membrane protein OmpA UniProt:Q1VCV6 (326 aa) fasta scores: E()=4.2e-16, 31.058% id in 293 aa. CDS contains a frameshift after codon 129. The sequence has been checked and is believed to be correct 316275008405 HMMPfam hit to PF00691, OmpA family, score 8.6e-07 316275008406 YadA-like C-terminal region; Region: YadA; pfam03895 316275008407 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 316275008408 ParB-like nuclease domain; Region: ParBc; pfam02195 316275008409 Similar to Escherichia coli Immunoglobulin-binding regulator IbrA UniProt:Q8KU24 (408 aa) fasta scores: E()=7.9e-44, 42.857% id in 392 aa. CDS contains a frameshift and deletion of 24 amino acid residues after codon 263. The sequence has been checked and is believed to be correct 316275008410 HMMPfam hit to PF01507, Phosphoadenosine phosphosulfate reductase, score 6e-05 316275008411 Similar to C-terminal part of Vibrio fischeri Hypothetical phage protein UniProt:Q5E397 (628 aa) fasta scores: E()=9.7e-22, 42.487% id in 193 aa. CDS may be truncated by the insertion of the upstream IS element and subsequent recombination events 316275008412 PS00214 Cytosolic fatty-acid binding proteins signature. 316275008414 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275008415 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275008416 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275008417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275008418 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275008419 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275008420 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275008421 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 316275008422 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 316275008423 ATP binding site [chemical binding]; other site 316275008424 substrate interface [chemical binding]; other site 316275008425 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 8.8e-36 316275008426 HMMPfam hit to PF00899, ThiF family, score 2.1e-63 316275008427 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 316275008428 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 316275008429 dimer interface [polypeptide binding]; other site 316275008430 putative functional site; other site 316275008431 putative MPT binding site; other site 316275008432 HMMPfam hit to PF03454, MoeA C-terminal region (domain IV), score 7.6e-20 316275008433 HMMPfam hit to PF00994, molybdopterin binding domain, score 9.8e-50 316275008434 PS01079 Molybdenum cofactor biosynthesis proteins signature 2. 316275008435 HMMPfam hit to PF03453, MoeA N-terminal region (domain I and II, score 6.8e-67 316275008436 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 316275008437 active site 316275008438 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 5.1e-52 316275008439 PS00859 GTP cyclohydrolase I signature 1. 316275008440 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 316275008441 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 316275008442 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 316275008443 putative active site [active] 316275008444 catalytic site [active] 316275008445 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 316275008446 putative active site [active] 316275008447 catalytic site [active] 316275008448 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 4.5e-08 316275008449 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 8.7e-08 316275008451 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 316275008452 Na2 binding site [ion binding]; other site 316275008453 putative substrate binding site 1 [chemical binding]; other site 316275008454 Na binding site 1 [ion binding]; other site 316275008455 putative substrate binding site 2 [chemical binding]; other site 316275008456 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 1.5e-10 316275008458 hypothetical protein; Provisional; Region: PRK04233 316275008459 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 316275008460 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275008461 HMMPfam hit to PF00563, EAL domain, score 1.1e-05 316275008462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316275008463 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 316275008464 putative active site [active] 316275008465 putative metal binding site [ion binding]; other site 316275008466 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 1.1e-11 316275008467 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 316275008468 substrate binding site [chemical binding]; other site 316275008469 HMMPfam hit to PF00160, Cyclophilin type peptidyl-prolyl cis-tr, score 1.6e-43 316275008470 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 316275008471 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 316275008472 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316275008473 active site 316275008474 HIGH motif; other site 316275008475 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 316275008476 KMSKS motif; other site 316275008477 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 316275008478 tRNA binding surface [nucleotide binding]; other site 316275008479 anticodon binding site; other site 316275008480 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 4.5e-204 316275008481 thymidine kinase; Provisional; Region: PRK04296 316275008482 HMMPfam hit to PF00265, Thymidine kinase, score 5e-87 316275008483 PS00603 Thymidine kinase cellular-type signature. 316275008484 HMMPfam hit to PF02839, Carbohydrate binding domain, score 8.8e-17 316275008485 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275008486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275008487 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=4.5e-119, 56.389% id in 493 aa. CDS contains a frameshift after codon 152 316275008488 HMMPfam hit to PF00801, no description, score 0.032 316275008489 HMMPfam hit to PF00704, Glycosyl hydrolases family,score 3.9e-122 316275008490 PS01095 Chitinases family 18 active site. 316275008491 HMMPfam hit to PF08329, Chitinase A, N-terminal domain, score 3.7e-75 316275008492 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 316275008493 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 316275008494 peptide binding site [polypeptide binding]; other site 316275008495 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275008496 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.8e-89 316275008497 Similar to Vibrio fluvialis Oligopeptide permease B OppB UniProt:Q5V9S1 (306 aa) fasta scores: E()=3.2e-83,86.071% id in 280 aa. CDS contains a nonsense mutation (TAA) after codon 25. The sequence has been checked and is believed to be correct 316275008498 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-56 316275008500 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275008501 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 316275008502 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316275008503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275008504 dimer interface [polypeptide binding]; other site 316275008505 conserved gate region; other site 316275008506 putative PBP binding loops; other site 316275008507 ABC-ATPase subunit interface; other site 316275008509 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.2e-43 316275008510 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275008511 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 316275008512 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316275008513 Walker A/P-loop; other site 316275008514 ATP binding site [chemical binding]; other site 316275008515 Q-loop/lid; other site 316275008516 ABC transporter signature motif; other site 316275008517 Walker B; other site 316275008518 D-loop; other site 316275008519 H-loop/switch region; other site 316275008520 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316275008521 HMMPfam hit to PF00005, ABC transporter score 3e-58 316275008522 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008523 PS00211 ABC transporters family signature. 316275008524 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter C-termi, score 2.5e-27 316275008525 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 316275008526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316275008527 Walker A/P-loop; other site 316275008528 ATP binding site [chemical binding]; other site 316275008529 Q-loop/lid; other site 316275008530 ABC transporter signature motif; other site 316275008531 Walker B; other site 316275008532 D-loop; other site 316275008533 H-loop/switch region; other site 316275008534 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316275008535 HMMPfam hit to PF00005, ABC transporter score 9.7e-69 316275008536 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008537 PS00211 ABC transporters family signature. 316275008538 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter C-termi, score 1.2e-33 316275008539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275008540 dimerization interface [polypeptide binding]; other site 316275008541 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275008542 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275008543 dimer interface [polypeptide binding]; other site 316275008544 putative CheW interface [polypeptide binding]; other site 316275008546 HMMPfam hit to PF00672, HAMP domain, score 1.4e-16 316275008547 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1e-53 316275008548 Uncharacterized conserved protein [Function unknown]; Region: COG2850 316275008549 HMMPfam hit to PF08007, Cupin superfamily protein,score 3.4e-110 316275008550 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 316275008551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275008552 FeS/SAM binding site; other site 316275008553 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.3e-27 316275008554 PS01087 Radical activating enzymes signature. 316275008555 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275008556 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275008557 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275008558 HMMPfam hit to PF01609, Transposase DDE domain,score 7.6e-28 316275008559 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 316275008560 Pyruvate formate lyase 1; Region: PFL1; cd01678 316275008561 coenzyme A binding site [chemical binding]; other site 316275008562 active site 316275008563 catalytic residues [active] 316275008564 glycine loop; other site 316275008565 HMMPfam hit to PF01228, Glycine radical, score 5.6e-58 316275008566 PS00850 Glycine radical signature. 316275008567 HMMPfam hit to PF02901, Pyruvate formate lyase,score 0 316275008568 formate transporter FocA; Region: formate_focA; TIGR04060 316275008569 HMMPfam hit to PF01226, Formate/nitrite transporter score 1.3e-130 316275008571 PS01006 Formate and nitrite transporters signature 2. 316275008572 PS01005 Formate and nitrite transporters signature 1. 316275008573 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 316275008574 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 316275008575 Walker A/P-loop; other site 316275008576 ATP binding site [chemical binding]; other site 316275008577 Q-loop/lid; other site 316275008578 ABC transporter signature motif; other site 316275008579 Walker B; other site 316275008580 D-loop; other site 316275008581 H-loop/switch region; other site 316275008582 HMMPfam hit to PF00005, ABC transporter score 1.2e-63 316275008583 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008584 PS00211 ABC transporters family signature. 316275008585 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 316275008586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275008587 substrate binding pocket [chemical binding]; other site 316275008588 membrane-bound complex binding site; other site 316275008589 hinge residues; other site 316275008590 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 7e-95 316275008591 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 316275008592 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 316275008593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275008594 dimer interface [polypeptide binding]; other site 316275008595 conserved gate region; other site 316275008596 putative PBP binding loops; other site 316275008597 ABC-ATPase subunit interface; other site 316275008598 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8e-26 316275008600 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275008601 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 316275008602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275008603 dimer interface [polypeptide binding]; other site 316275008604 conserved gate region; other site 316275008605 putative PBP binding loops; other site 316275008606 ABC-ATPase subunit interface; other site 316275008607 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.7e-24 316275008609 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275008610 glutaredoxin 2; Provisional; Region: PRK10387 316275008611 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 316275008612 C-terminal domain interface [polypeptide binding]; other site 316275008613 GSH binding site (G-site) [chemical binding]; other site 316275008614 catalytic residues [active] 316275008615 putative dimer interface [polypeptide binding]; other site 316275008616 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 316275008617 N-terminal domain interface [polypeptide binding]; other site 316275008618 HMMPfam hit to PF04399, Glutaredoxin 2, C terminal domain, score 7.5e-34 316275008619 HMMPfam hit to PF02798, Glutathione S-transferase,N-terminal, score 0.0036 316275008620 PS00195 Glutaredoxin active site. 316275008621 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 316275008622 putative catalytic site [active] 316275008623 putative phosphate binding site [ion binding]; other site 316275008624 active site 316275008625 metal binding site A [ion binding]; metal-binding site 316275008626 DNA binding site [nucleotide binding] 316275008627 putative AP binding site [nucleotide binding]; other site 316275008628 putative metal binding site B [ion binding]; other site 316275008629 HMMPfam hit to PF03372,Endonuclease/Exonuclease/phosphatase fa, score 1.4e-47 316275008630 PS00726 AP endonucleases family 1 signature 1. 316275008631 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275008632 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275008633 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275008634 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00018 316275008635 Similar to Vibrio cholerae Multidrug resistance protein, UniProt:Q9KTI8 (1036 aa) fasta scores: E()=0, 82.625% id in 1036 aa. CDS contains a frameshift after codon 217 316275008637 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 316275008638 Ligand Binding Site [chemical binding]; other site 316275008639 HMMPfam hit to PF06508, ExsB, score 3.8e-104 316275008640 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 316275008641 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 316275008642 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275008643 catalytic residue [active] 316275008644 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 2.9e-51 316275008645 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 316275008646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275008647 putative DNA binding site [nucleotide binding]; other site 316275008648 putative Zn2+ binding site [ion binding]; other site 316275008649 AsnC family; Region: AsnC_trans_reg; pfam01037 316275008650 Predicted helix-turn-helix motif with score 1374.000, SD 3.87 at aa 23-44, sequence ISLSELAEAVNLTTTPCWKRLK 316275008651 PS00519 Bacterial regulatory proteins, asnC family signature. 316275008652 HMMPfam hit to PF01037, AsnC family, score 5.3e-30 316275008653 acyl-CoA thioesterase II; Provisional; Region: PRK10526 316275008654 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 316275008655 active site 316275008656 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 316275008657 catalytic triad [active] 316275008658 dimer interface [polypeptide binding]; other site 316275008659 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 5.8e-53 316275008660 HMMPfam hit to PF02551, Acyl-CoA thioesterase, score 6.4e-33 316275008661 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 316275008662 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275008663 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316275008664 DNA binding site [nucleotide binding] 316275008665 active site 316275008666 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferase, score 7.2e-09 316275008668 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 316275008669 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 316275008670 metal binding site [ion binding]; metal-binding site 316275008671 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 6.9e-97 316275008672 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316275008673 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275008674 ABC-ATPase subunit interface; other site 316275008675 dimer interface [polypeptide binding]; other site 316275008676 putative PBP binding regions; other site 316275008678 HMMPfam hit to PF00950, ABC 3 transport family, score 2.6e-48 316275008679 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316275008680 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316275008681 HMMPfam hit to PF00005, ABC transporter score 3e-37 316275008682 PS00211 ABC transporters family signature. 316275008683 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008684 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 316275008685 HMMPfam hit to PF06226, Protein of unknown function (DUF1007), score 2.2e-32 316275008686 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 316275008688 HMMPfam hit to PF03824, High-affinity nickel-transport protein, score 4.6e-22 316275008689 NADH dehydrogenase; Region: NADHdh; cl00469 316275008690 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316275008691 GAF domain; Region: GAF_3; pfam13492 316275008692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275008693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275008694 metal binding site [ion binding]; metal-binding site 316275008695 active site 316275008696 I-site; other site 316275008697 HMMPfam hit to PF00990, GGDEF domain, score 3.9e-65 316275008699 sensor protein PhoQ; Provisional; Region: PRK10815 316275008700 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 316275008701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275008702 ATP binding site [chemical binding]; other site 316275008703 Mg2+ binding site [ion binding]; other site 316275008704 G-X-G motif; other site 316275008705 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.6e-23 316275008707 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316275008708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275008709 active site 316275008710 phosphorylation site [posttranslational modification] 316275008711 intermolecular recognition site; other site 316275008712 dimerization interface [polypeptide binding]; other site 316275008713 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275008714 DNA binding site [nucleotide binding] 316275008715 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 7.9e-22 316275008716 HMMPfam hit to PF00072, Response regulator receiver domain, score 7.3e-24 316275008717 Predicted membrane protein [Function unknown]; Region: COG3212 316275008718 Uncharacterized conserved protein [Function unknown]; Region: COG0398 316275008719 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316275008721 TfoX N-terminal domain; Region: TfoX_N; pfam04993 316275008722 TfoX C-terminal domain; Region: TfoX_C; pfam04994 316275008723 HMMPfam hit to PF04994, TfoX C-terminal domain, score 1.6e-34 316275008724 HMMPfam hit to PF04993, TfoX N-terminal domain, score 3.2e-35 316275008725 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 316275008726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275008727 DNA binding site [nucleotide binding] 316275008728 domain linker motif; other site 316275008729 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 316275008730 dimerization interface [polypeptide binding]; other site 316275008731 ligand binding site [chemical binding]; other site 316275008732 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 5.2e-20 316275008733 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 6.6e-11 316275008734 Predicted helix-turn-helix motif with score 1818.000, SD 5.38 at aa 2-23, sequence ATIKDVAKLASVSTTTVSHVIN 316275008735 PS00356 Bacterial regulatory proteins, lacI family signature. 316275008736 chaperone protein TorD; Validated; Region: torD; PRK04976 316275008737 HMMPfam hit to PF06192, Cytoplasmic chaperone TorD, score 3e-42 316275008738 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 316275008739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275008740 active site 316275008741 phosphorylation site [posttranslational modification] 316275008742 intermolecular recognition site; other site 316275008743 dimerization interface [polypeptide binding]; other site 316275008744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275008745 DNA binding site [nucleotide binding] 316275008746 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-37 316275008747 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.7e-17 316275008748 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275008749 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 316275008750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275008751 RNA binding surface [nucleotide binding]; other site 316275008752 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 316275008753 probable active site [active] 316275008754 HMMPfam hit to PF01479, S4 domain, score 2.3e-09 316275008755 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.1e-15 316275008756 PS01149 Rsu family of pseudouridine synthase signature. 316275008757 hypothetical protein; Provisional; Region: PRK13661 316275008758 HMMPfam hit to PF07155, Protein of unknown function (DUF1393), score 1.1e-96 316275008760 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316275008761 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316275008762 Walker A/P-loop; other site 316275008763 ATP binding site [chemical binding]; other site 316275008764 Q-loop/lid; other site 316275008765 ABC transporter signature motif; other site 316275008766 Walker B; other site 316275008767 D-loop; other site 316275008768 H-loop/switch region; other site 316275008769 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 316275008770 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316275008771 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 316275008772 Walker A/P-loop; other site 316275008773 ATP binding site [chemical binding]; other site 316275008774 Q-loop/lid; other site 316275008775 ABC transporter signature motif; other site 316275008776 Walker B; other site 316275008777 D-loop; other site 316275008778 H-loop/switch region; other site 316275008779 HMMPfam hit to PF00005, ABC transporter score 8.6e-38 316275008780 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008781 PS00211 ABC transporters family signature. 316275008782 HMMPfam hit to PF00005, ABC transporter score 7e-48 316275008783 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008784 PS00211 ABC transporters family signature. 316275008785 Predicted helix-turn-helix motif with score 981.000, SD 2.53 at aa 522-543, sequence FSQPELLDKANLTVTSLYELVN 316275008786 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 316275008787 HMMPfam hit to PF02361, Cobalt transport protein, score 2.9e-24 316275008789 Similar to N-terminal part of Vibrio fischeri Hypothetical protein UniProt:Q5E4I9 (446 aa) fasta scores: E()=9.2e-45, 75.974% id in 154 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275008790 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275008791 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275008792 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275008793 Similar to C-terminal part of Vibrio fischeri ATP-dependent helicase HrpA UniProt:Q5E4J4 (780 aa) fasta scores: E()=1.2e-64, 57.895% id in 266 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275008794 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 316275008795 dimerization interface [polypeptide binding]; other site 316275008796 substrate binding site [chemical binding]; other site 316275008797 active site 316275008798 calcium binding site [ion binding]; other site 316275008799 HMMPfam hit to PF02253, Phospholipase A1, score 2.2e-32 316275008801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275008802 binding surface 316275008803 TPR motif; other site 316275008804 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 316275008805 HMMPfam hit to PF02335, Cytochrome c552, score 1.9e-279 316275008806 PS00190 Cytochrome c family heme-binding site signature. 316275008807 PS00190 Cytochrome c family heme-binding site signature. 316275008808 PS00190 Cytochrome c family heme-binding site signature. 316275008809 PS00190 Cytochrome c family heme-binding site signature. 316275008810 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 316275008811 PS00190 Cytochrome c family heme-binding site signature. 316275008812 PS00190 Cytochrome c family heme-binding site signature. 316275008813 PS00190 Cytochrome c family heme-binding site signature. 316275008814 PS00190 Cytochrome c family heme-binding site signature. 316275008815 PS00190 Cytochrome c family heme-binding site signature. 316275008816 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 316275008817 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 316275008819 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0026 316275008820 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.011 316275008821 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 6.9e-06 316275008822 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275008823 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 316275008824 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 316275008825 HMMPfam hit to PF03916, Polysulphide reductase, NrfD, score 1.6e-88 316275008827 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 316275008829 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 7e-63 316275008830 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 316275008831 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316275008832 catalytic residues [active] 316275008833 central insert; other site 316275008835 HMMPfam hit to PF08534, Redoxin, score 2.2e-17 316275008836 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 316275008837 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 2.9e-34 316275008839 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 316275008840 aspartate racemase; Region: asp_race; TIGR00035 316275008841 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 2.6e-24 316275008842 PS00923 Aspartate and glutamate racemases signature 1. 316275008843 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 316275008844 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 316275008846 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 5.8e-140 316275008847 cell density-dependent motility repressor; Provisional; Region: PRK10082 316275008848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275008849 LysR substrate binding domain; Region: LysR_substrate; pfam03466 316275008850 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.3e-13 316275008851 Predicted helix-turn-helix motif with score 1432.000, SD 4.06 at aa 18-39, sequence RNFSQAAILRNVTQPAFSRRIR 316275008852 PS00044 Bacterial regulatory proteins, lysR family signature. 316275008853 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.3e-06 316275008854 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 316275008855 active site 316275008856 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 316275008857 HMMPfam hit to PF01569, PAP2 superfamily, score 1.4e-20 316275008859 Similar to Vibrio fischeri (strain ATCC 700601/ES114) long-chain fatty acid transport protein. UniProt:Q5E4K8 (EMBL:CP000020) (447 aa) fasta scores: E()=1.2e-23, 63.8% id in 221 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275008860 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 6.1e-06 316275008861 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008862 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=4.5e-120, 56.795% id in 493 aa. CDS contains a frameshift after codon 96 316275008863 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275008864 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275008865 Similar to N-terminal part of Vibrio vulnificus Membrane-fusion protein UniProt:Q8D507 (463 aa) fasta scores: E()=1.1e-09, 27.273% id in 253 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275008867 Similar to Psychroerythus ABC transporter ATP-binding/permease protein UniProt:Q481X4 (685 aa) fasta scores: E()=7.6e-49, 32.405% id in 682 aa. CDS contains a frameshift after codon 288. The sequence has been checked and is believed to be correct 316275008868 HMMPfam hit to PF00005, ABC transporter score 3.4e-16 316275008869 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008871 Similar to part of Erwinia chrysanthemi Proteases secretion ATP-binding protein PrtD UniProt:P23596 (575 aa) fasta scores: E()=9.3e-10, 26.006% id in 323 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275008872 HMMPfam hit to PF00005, ABC transporter score 9.2e-08 316275008873 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275008874 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275008875 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275008876 Similar to part of Vibrio fischeri Multidrug resistance protein A UniProt:Q5E6H3 (346 aa) fasta scores: E()=7.6e-74, 87.550% id in 249 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275008877 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.6e-20 316275008878 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 316275008879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275008880 putative substrate translocation pore; other site 316275008881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275008883 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.1e-52 316275008884 PS00217 Sugar transport proteins signature 2. 316275008885 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 316275008886 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 316275008887 active site 316275008888 uracil binding [chemical binding]; other site 316275008889 HMMPfam hit to PF01479, S4 domain, score 4.1e-08 316275008890 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 4.2e-15 316275008891 PS01149 Rsu family of pseudouridine synthase signature. 316275008892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275008893 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 316275008894 putative substrate translocation pore; other site 316275008896 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.6e-59 316275008897 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 316275008898 Similar to Vibrio fischeri Nucleoside-diphosphate-sugar epimerase UniProt:Q5E6G8 (480 aa) fasta scores: E()=3.8e-155, 75.949% id in 474 aa. CDS contains a frameshift after codon 28. The sequence has been checked and is believed to be correct 316275008900 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.0015 316275008901 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 316275008902 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 316275008904 HMMPfam hit to PF01554, MatE, score 6.9e-28 316275008905 HMMPfam hit to PF01554, MatE, score 8e-20 316275008906 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 316275008907 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316275008908 Walker A/P-loop; other site 316275008909 ATP binding site [chemical binding]; other site 316275008910 Q-loop/lid; other site 316275008911 ABC transporter signature motif; other site 316275008912 Walker B; other site 316275008913 D-loop; other site 316275008914 H-loop/switch region; other site 316275008915 HMMPfam hit to PF00005, ABC transporter score 2e-58 316275008916 PS00017 ATP/GTP-binding site motif A (P-loop). 316275008917 PS00211 ABC transporters family signature. 316275008918 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 316275008919 FtsX-like permease family; Region: FtsX; pfam02687 316275008921 HMMPfam hit to PF02687, Predicted permease, score 6.8e-19 316275008922 HMMPfam hit to PF02687, Predicted permease, score 6.1e-19 316275008923 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 316275008925 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 316275008926 HMMPfam hit to PF06965, Na+/H+ antiporter, score 9.1e-238 316275008928 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275008929 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275008930 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275008931 HMMPfam hit to PF01609, Transposase DDE domain, score 7.6e-28 316275008932 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 316275008933 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 316275008934 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 316275008935 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 316275008936 HMMPfam hit to PF07055, Short-chain alcohol dehydrogenase, score 7e-303 316275008937 putative transporter; Provisional; Region: PRK04972 316275008938 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 316275008939 TrkA-C domain; Region: TrkA_C; pfam02080 316275008940 TrkA-C domain; Region: TrkA_C; pfam02080 316275008941 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 316275008943 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 7.5e-61 316275008944 HMMPfam hit to PF02080, TrkA-C domain, score 2.1e-10 316275008945 HMMPfam hit to PF02080, TrkA-C domain, score 3.4e-11 316275008946 HMMPfam hit to PF06826, Predicted Permease Membrane Region, score 1.2e-33 316275008947 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 316275008948 GSH binding site [chemical binding]; other site 316275008949 catalytic residues [active] 316275008950 HMMPfam hit to PF00462, Glutaredoxin, score 1.1e-12 316275008951 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 316275008952 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 316275008953 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 316275008954 putative active site [active] 316275008955 HMMPfam hit to PF01380, SIS domain, score 9.4e-33 316275008956 HMMPfam hit to PF01418, Helix-turn-helix domain, rpiR family, score 2.4e-46 316275008957 Predicted helix-turn-helix motif with score 1545.000, SD 4.45 at aa 35-56, sequence SSIATLAKMADVSEPTVNRFCR 316275008958 putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799 316275008959 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275008960 catalytic residue [active] 316275008961 HMMPfam hit to PF01212, Beta-eliminating lyase, score 0.0017 316275008962 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase con, score 3.6e-21 316275008963 Predicted membrane protein [Function unknown]; Region: COG2431 316275008964 HMMPfam hit to PF03956, Membrane protein of unknown function (DUF340, score 1e-47 316275008966 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 316275008967 Similar to N-terminal part of Vibrio fischeri DNA transformation protein TfoX UniProt:Q5E6F5 (209 aa) fasta scores: E()=3e-32, 86.598% id in 97 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275008968 HMMPfam hit to PF04993, TfoX N-terminal domain, score 3.3e-23 316275008969 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275008970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275008971 Homeodomain-like domain; Region: HTH_23; cl17451 316275008972 Winged helix-turn helix; Region: HTH_29; pfam13551 316275008973 Homeodomain-like domain; Region: HTH_32; pfam13565 316275008974 sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273 316275008975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 316275008976 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 316275008978 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275008979 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 316275008980 homodimer interface [polypeptide binding]; other site 316275008981 substrate-cofactor binding pocket; other site 316275008982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275008983 catalytic residue [active] 316275008984 HMMPfam hit to PF00266, Aminotransferase class-V, score 7.3e-67 316275008985 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 316275008986 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275008987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275008988 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275008989 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275008990 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275008991 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275008992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275008993 Similar to C-terminal part of Escherichia coli Long-chain fatty acid transport protein precursor UniProt:P10384 (448 aa) fasta scores: E()=9.5e-16, 33.505% id in 194 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275008994 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 3.3e-09 316275008995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 316275008996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275008997 Coenzyme A binding pocket [chemical binding]; other site 316275008998 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.8e-14 316275008999 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 316275009000 nudix motif; other site 316275009001 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 316275009002 active site 316275009004 HMMPfam hit to PF00293, NUDIX domain, score 8e-14 316275009005 HMMPfam hit to PF01569, PAP2 superfamily, score 2.1e-16 316275009006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275009007 binding surface 316275009008 TPR motif; other site 316275009009 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316275009010 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275009011 binding surface 316275009012 TPR motif; other site 316275009013 ATP synthase subunit D; Region: ATP-synt_D; cl00613 316275009014 HMMPfam hit to PF08238, Sel1 repeat, score 2.7e-07 316275009015 HMMPfam hit to PF08238, Sel1 repeat, score 1.7e-07 316275009016 HMMPfam hit to PF00515, Tetratricopeptide repeat, score 5.7e-06 316275009017 HMMPfam hit to PF08238, Sel1 repeat, score 5.9e-05 316275009018 HMMPfam hit to PF08238, Sel1 repeat, score 0.0037 316275009019 HMMPfam hit to PF08238, Sel1 repeat, score 2.2 316275009020 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316275009021 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316275009022 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 7.2e-29 316275009024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275009025 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 316275009026 Walker A motif; other site 316275009027 ATP binding site [chemical binding]; other site 316275009028 Walker B motif; other site 316275009029 arginine finger; other site 316275009031 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275009032 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275009033 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275009034 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E4L4 (341 aa) fasta scores: E()=1.7e-104, 72.807% id in 342 aa. CDS contains a frameshift after codon 240. The sequence has been checked and is believed to be correct 316275009035 HMMPfam hit to PF08238, Sel1 repeat, score 0.34 316275009036 HMMPfam hit to PF08238, Sel1 repeat, score 0.76 316275009037 HMMPfam hit to PF08238, Sel1 repeat, score 0.0036 316275009038 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 316275009039 YccA-like proteins; Region: YccA_like; cd10433 316275009040 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 5e-37 316275009042 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 316275009043 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 316275009044 Walker A/P-loop; other site 316275009045 ATP binding site [chemical binding]; other site 316275009046 Q-loop/lid; other site 316275009047 ABC transporter signature motif; other site 316275009048 Walker B; other site 316275009049 D-loop; other site 316275009050 H-loop/switch region; other site 316275009051 HMMPfam hit to PF00005, ABC transporter score 2.2e-64 316275009052 PS00211 ABC transporters family signature. 316275009053 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275009055 dimer interface [polypeptide binding]; other site 316275009056 conserved gate region; other site 316275009057 putative PBP binding loops; other site 316275009058 ABC-ATPase subunit interface; other site 316275009059 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.3e-27 316275009061 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275009062 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 316275009063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275009064 conserved gate region; other site 316275009065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275009066 dimer interface [polypeptide binding]; other site 316275009067 conserved gate region; other site 316275009068 putative PBP binding loops; other site 316275009069 ABC-ATPase subunit interface; other site 316275009070 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.1e-14 316275009072 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275009073 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 316275009074 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275009075 substrate binding pocket [chemical binding]; other site 316275009076 membrane-bound complex binding site; other site 316275009077 hinge residues; other site 316275009078 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 316275009079 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 316275009080 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 316275009081 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 316275009082 transcriptional regulator protein; Region: phnR; TIGR03337 316275009083 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316275009084 DNA-binding site [nucleotide binding]; DNA binding site 316275009085 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 316275009086 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.2e-17 316275009087 PS00043 Bacterial regulatory proteins, gntR family signature. 316275009088 HMMPfam hit to PF07702, UTRA domain, score 2.5e-10 316275009089 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 316275009090 Protein of unknown function (DUF3334); Region: DUF3334; pfam11813 316275009091 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 316275009092 FAD binding domain; Region: FAD_binding_4; pfam01565 316275009093 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 316275009094 HMMPfam hit to PF01565, FAD binding domain, score 6.2e-47 316275009095 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009096 HMMPfam hit to PF02913, FAD linked oxidases, C-terminal domain, score 2e-65 316275009097 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275009098 FOG: CBS domain [General function prediction only]; Region: COG0517 316275009099 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 316275009100 HMMPfam hit to PF00571, CBS domain pair, score 3.4e-29 316275009101 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 316275009102 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316275009103 putative active site [active] 316275009104 putative NTP binding site [chemical binding]; other site 316275009105 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 316275009106 HMMPfam hit to PF00078, Reverse transcriptase (RNA-dependent DNA pol, score 3.4e-49 316275009107 HMMPfam hit to PF08388, Group II intron, maturase-specific domain, score 1.2e-23 316275009108 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 316275009109 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 316275009110 metal-binding site [ion binding] 316275009111 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 316275009112 Soluble P-type ATPase [General function prediction only]; Region: COG4087 316275009113 HMMPfam hit to PF00403, Heavy-metal-associated domain, score 1.7e-05 316275009114 PS01047 Heavy-metal-associated domain. 316275009116 HMMPfam hit to PF00122, E1-E2 ATPase, score 3.3e-92 316275009117 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.1e-28 316275009118 PS00154 E1-E2 ATPases phosphorylation site. 316275009119 PS01229 Hypothetical cof family signature 2. 316275009120 Predicted helix-turn-helix motif with score 1173.000, SD 3.18 at aa 702-723, sequence NRLEELAPMVALSKATLSNIRQ 316275009121 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 316275009122 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275009123 Zn2+ binding site [ion binding]; other site 316275009124 Mg2+ binding site [ion binding]; other site 316275009125 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275009127 Similar to Colwellia psychrerythraea ABC transporter protein UniProt:Q481X5 (554 aa) fasta scores: E()=1.1e-22, 41.361% id in 191 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275009129 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275009130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275009131 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275009132 YcxB-like protein; Region: YcxB; pfam14317 316275009134 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 316275009135 Chloramphenicol acetyltransferase; Region: CAT; cl02008 316275009136 HMMPfam hit to PF00302, Chloramphenicol acetyltransferase, score 1.1e-11 316275009137 Herpesvirus UL25 family; Region: Herpes_UL25; pfam01499 316275009138 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275009139 dimer interface [polypeptide binding]; other site 316275009140 putative CheW interface [polypeptide binding]; other site 316275009141 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 316275009142 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.5e-11 316275009143 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 316275009144 MOSC domain; Region: MOSC; pfam03473 316275009145 HMMPfam hit to PF03473, MOSC domain, score 8.6e-34 316275009146 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 316275009147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275009148 catalytic residue [active] 316275009149 HMMPfam hit to PF00266, Aminotransferase class-V, score 5.1e-41 316275009150 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 316275009151 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 316275009152 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 316275009153 catalytic triad [active] 316275009154 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.5e-06 316275009155 Cupin domain; Region: Cupin_2; cl17218 316275009156 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316275009157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275009158 Predicted helix-turn-helix motif with score 1186.000, SD 3.23 at aa 177-198, sequence WPLKIWGNEVGASERTLSRLFV 316275009159 PS00041 Bacterial regulatory proteins, araC family signature. 316275009160 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.8e-06 316275009161 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 316275009162 PLD-like domain; Region: PLDc_2; pfam13091 316275009163 putative active site [active] 316275009164 catalytic site [active] 316275009165 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 316275009166 PLD-like domain; Region: PLDc_2; pfam13091 316275009167 putative active site [active] 316275009168 catalytic site [active] 316275009169 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.058 316275009170 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.016 316275009171 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 316275009172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275009173 ATP binding site [chemical binding]; other site 316275009174 putative Mg++ binding site [ion binding]; other site 316275009175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275009176 nucleotide binding region [chemical binding]; other site 316275009177 ATP-binding site [chemical binding]; other site 316275009178 Double zinc ribbon; Region: DZR; pfam12773 316275009179 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 4.3e-37 316275009180 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.9e-09 316275009181 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.7e-12 316275009182 Cytochrome C' Region: Cytochrom_C_2; pfam01322 316275009183 PS00430 TonB-dependent receptor proteins signature 1. 316275009184 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 316275009185 5S rRNA interface [nucleotide binding]; other site 316275009186 CTC domain interface [polypeptide binding]; other site 316275009187 L16 interface [polypeptide binding]; other site 316275009188 HMMPfam hit to PF01386, Ribosomal L25p family, score 1.6e-31 316275009189 Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187 316275009190 HMMPfam hit to PF03724, Domain of unknown function (306), score 3e-24 316275009191 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=6.8e-78, 54.0% id in 496 aa. CDS contains translational stop codons after codon 160 (TAG) and 171 (TAA) 316275009192 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275009193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275009194 Similar to Vibrio harveyi 3-oxoacyl-[acyl-carrier-protein] synthase 2 FabF UniProt:P55338 (EMBL:U39441 (414 aa) fasta scores: E()=2e-48, 38.517% id in 418 aa. The insertion of the downstream IS element truncates the last amino acid residue of the CDS. There is an inframe translational stop codon 8 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275009195 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 5.4e-47 316275009196 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 1.9e-42 316275009197 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 316275009198 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 316275009199 NAD(P) binding site [chemical binding]; other site 316275009200 homotetramer interface [polypeptide binding]; other site 316275009201 homodimer interface [polypeptide binding]; other site 316275009202 active site 316275009203 HMMPfam hit to PF00106, short chain dehydrogenase, score 7.8e-27 316275009204 PS00063 Aldo/keto reductase family active site signature. 316275009205 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 316275009206 putative active site 1 [active] 316275009207 HMMPfam hit to PF07977, FabA-like domain, score 0.0016 316275009208 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 316275009209 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316275009210 dimer interface [polypeptide binding]; other site 316275009211 active site 316275009212 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 2.3e-37 316275009213 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 1.6e-07 316275009214 PS00606 Beta-ketoacyl synthases active site. 316275009215 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 316275009216 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275009217 Predicted exporter [General function prediction only]; Region: COG4258 316275009219 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 316275009220 HMMPfam hit to PF03548, Outer membrane lipoprotein carrier protein L, score 0.0035 316275009222 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 316275009223 active site 316275009224 HMMPfam hit to PF03061, Thioesterase superfamily, score 8.4e-09 316275009225 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316275009226 active sites [active] 316275009227 tetramer interface [polypeptide binding]; other site 316275009228 HMMPfam hit to PF00221, Phenylalanine and histidine ammonia-lyase, score 7e-132 316275009229 PS00488 Phenylalanine and histidine ammonia-lyases signature. 316275009230 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316275009231 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 316275009232 Ligand binding site; other site 316275009233 Putative Catalytic site; other site 316275009234 DXD motif; other site 316275009235 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316275009236 putative acyl-acceptor binding pocket; other site 316275009237 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 0.0019 316275009238 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.5e-17 316275009239 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 316275009240 active site 2 [active] 316275009241 active site 1 [active] 316275009242 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 316275009243 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 316275009244 acyl-activating enzyme (AAE) consensus motif; other site 316275009245 AMP binding site [chemical binding]; other site 316275009246 active site 316275009247 CoA binding site [chemical binding]; other site 316275009248 Predicted membrane protein [Function unknown]; Region: COG4648 316275009250 acyl carrier protein; Provisional; Region: PRK05350 316275009251 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 3.4e-09 316275009252 Phosphopantetheine attachment site; Region: PP-binding; cl09936 316275009253 PS00012 Phosphopantetheine attachment site. 316275009254 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 316275009255 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 316275009256 putative acyl-acceptor binding pocket; other site 316275009257 HMMPfam hit to PF01553, Acyltransferase, score 2.8e-15 316275009259 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 316275009260 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 316275009261 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275009262 O-methyltransferase; Region: Methyltransf_2; pfam00891 316275009263 HMMPfam hit to PF00891, O-methyltransferase, score 1.2e-05 316275009264 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 316275009265 HMMPfam hit to PF01494, FAD binding domain, score 0.00017 316275009266 HMMPfam hit to PF04820, Tryptophan halogenase, score 7.4e-07 316275009267 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00038 316275009268 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 316275009269 putative metal binding site [ion binding]; other site 316275009270 HMMPfam hit to PF06185, YecM protein, score 2.4e-89 316275009271 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 316275009272 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 316275009273 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 316275009274 active site 316275009275 HIGH motif; other site 316275009276 KMSK motif region; other site 316275009277 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 316275009278 tRNA binding surface [nucleotide binding]; other site 316275009279 anticodon binding site; other site 316275009280 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 1.1e-29 316275009281 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 3.3e-180 316275009282 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275009283 HMMPfam hit to PF05746, DALR anticodon binding domain, score 2.4e-53 316275009284 hypothetical protein; Provisional; Region: PRK01816 316275009285 HMMPfam hit to PF04217, Protein of unknown function, DUF412, score 1.2e-84 316275009287 propionate/acetate kinase; Provisional; Region: PRK12379 316275009288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316275009289 nucleotide binding site [chemical binding]; other site 316275009290 butyrate kinase; Provisional; Region: PRK03011 316275009291 HMMPfam hit to PF00871, Acetokinase family, score 5.5e-219 316275009292 PS01075 Acetate and butyrate kinases family signature 1. 316275009293 Predicted helix-turn-helix motif with score 1113.000, SD 2.98 at aa 27-48, sequence EHLTGLAECLGLPEARIKWKLD 316275009294 PS01076 Acetate and butyrate kinases family signature 2. 316275009295 phosphate acetyltransferase; Reviewed; Region: PRK05632 316275009296 DRTGG domain; Region: DRTGG; pfam07085 316275009297 phosphate acetyltransferase; Region: pta; TIGR00651 316275009298 HMMPfam hit to PF07085, DRTGG domain, score 1.1e-55 316275009299 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 1.1e-180 316275009300 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275009301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275009302 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275009303 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275009304 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275009305 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275009306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275009307 Similar to Vibrio cholerae Hemolysin secretion protein precursor hlyB UniProt:P15492, E()=1e-36, and to Escherichia coli Serine chemotaxis receptor (PDB 1QU7), evalue=5e-16 identity=(59, 241). Expression may be regulated by Fur. The insertion of the downstream IS element truncates the last 7 amino acid residues of the CDS. There is an inframe translational stop codon 8 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional. Expression may be regulated by Fur 316275009308 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 3e-51 316275009309 HMMPfam hit to PF00672, HAMP domain, score 1.3e-15 316275009311 PBP superfamily domain; Region: PBP_like_2; cl17296 316275009312 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 2.3e-08 316275009313 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 316275009314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275009315 dimer interface [polypeptide binding]; other site 316275009316 conserved gate region; other site 316275009317 putative PBP binding loops; other site 316275009318 ABC-ATPase subunit interface; other site 316275009320 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.1e-15 316275009321 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275009322 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 316275009323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275009324 dimer interface [polypeptide binding]; other site 316275009325 conserved gate region; other site 316275009326 putative PBP binding loops; other site 316275009327 ABC-ATPase subunit interface; other site 316275009329 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.9e-30 316275009330 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275009331 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14253 316275009332 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 316275009333 Walker A/P-loop; other site 316275009334 ATP binding site [chemical binding]; other site 316275009335 Q-loop/lid; other site 316275009336 ABC transporter signature motif; other site 316275009337 Walker B; other site 316275009338 D-loop; other site 316275009339 H-loop/switch region; other site 316275009340 HMMPfam hit to PF00005, ABC transporter score 6.9e-52 316275009341 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009342 PS00211 ABC transporters family signature. 316275009343 Similar to C-terminal part of Bacteriophage p2 Presumed portal vertex protein (GpQ) UniProt:P25480 (344 aa) fasta scores: E()=8.3e-07, 40.000% id in 90 aa. The CDS appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275009344 Similar to Escherichia coli Colicin-E2 immunity protein (ImmE2) UniProt:P04482 (86 aa) fasta scores: E()=2.6e-07, 60.000% id in 45 aa. The CDS appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275009346 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 316275009348 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275009349 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829 316275009350 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316275009351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275009352 dimerization interface [polypeptide binding]; other site 316275009353 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275009354 dimer interface [polypeptide binding]; other site 316275009355 putative CheW interface [polypeptide binding]; other site 316275009356 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.9e-65 316275009357 HMMPfam hit to PF00672, HAMP domain, score 3.8e-20 316275009359 TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956 316275009360 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 316275009361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275009362 dimer interface [polypeptide binding]; other site 316275009363 phosphorylation site [posttranslational modification] 316275009364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275009365 ATP binding site [chemical binding]; other site 316275009366 Mg2+ binding site [ion binding]; other site 316275009367 G-X-G motif; other site 316275009368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275009369 active site 316275009370 phosphorylation site [posttranslational modification] 316275009371 intermolecular recognition site; other site 316275009372 dimerization interface [polypeptide binding]; other site 316275009373 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316275009374 putative binding surface; other site 316275009375 active site 316275009376 HMMPfam hit to PF01627, Hpt domain, score 1e-07 316275009377 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-28 316275009378 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 7.4e-34 316275009379 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.1e-26 316275009380 HMMPfam hit to PF00672, HAMP domain, score 2.3e-08 316275009382 TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955 316275009383 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 316275009384 putative ligand binding site [chemical binding]; other site 316275009385 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 3.5e-14 316275009386 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 316275009387 active site 316275009388 dimer interfaces [polypeptide binding]; other site 316275009389 catalytic residues [active] 316275009390 HMMPfam hit to PF02142, MGS-like domain, score 1.6e-26 316275009391 PS01335 Methylglyoxal synthase active site. 316275009392 DNA helicase IV; Provisional; Region: helD; PRK11054 316275009393 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 316275009394 Part of AAA domain; Region: AAA_19; pfam13245 316275009395 Family description; Region: UvrD_C_2; pfam13538 316275009396 HMMPfam hit to PF00580, UvrD/REP helicase, score 2.4e-10 316275009397 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009398 TIGR01666 family membrane protein; Region: YCCS 316275009399 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 316275009400 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 316275009401 HMMPfam hit to PF05976, Bacterial membrane protein of unknown functi, score 0 316275009403 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 316275009404 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 316275009405 dimer interface [polypeptide binding]; other site 316275009406 active site 316275009407 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316275009408 catalytic residues [active] 316275009409 substrate binding site [chemical binding]; other site 316275009410 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 1.9e-06 316275009411 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 316275009412 HMMPfam hit to PF03435, Saccharopine dehydrogenase, score 8.6e-160 316275009413 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 316275009414 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316275009415 inhibitor-cofactor binding pocket; inhibition site 316275009416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275009417 catalytic residue [active] 316275009418 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 316275009419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275009420 catalytic residue [active] 316275009421 HMMPfam hit to PF00282, Pyridoxal-dependent decarboxylase conse, score 4.5e-35 316275009422 PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. 316275009423 HMMPfam hit to PF00202, Aminotransferase class-III, score 5.5e-109 316275009424 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 316275009425 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 3.1e-41 316275009427 PS00379 CDP-alcohol phosphatidyltransferases signature. 316275009428 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 316275009429 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 316275009430 GIY-YIG motif/motif A; other site 316275009431 active site 316275009432 catalytic site [active] 316275009433 putative DNA binding site [nucleotide binding]; other site 316275009434 metal binding site [ion binding]; metal-binding site 316275009435 UvrB/uvrC motif; Region: UVR; pfam02151 316275009436 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 316275009437 Helix-hairpin-helix motif; Region: HHH; pfam00633 316275009438 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.0012 316275009439 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.00052 316275009440 HMMPfam hit to PF08459, UvrC Helix-hairpin-helix N-terminal, score 4.2e-84 316275009441 HMMPfam hit to PF02151, UvrB/uvrC motif, score 3.7e-10 316275009442 HMMPfam hit to PF01541, GIY-YIG catalytic domain, score 2.8e-31 316275009443 response regulator; Provisional; Region: PRK09483 316275009444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275009445 active site 316275009446 phosphorylation site [posttranslational modification] 316275009447 intermolecular recognition site; other site 316275009448 dimerization interface [polypeptide binding]; other site 316275009449 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316275009450 DNA binding residues [nucleotide binding] 316275009451 dimerization interface [polypeptide binding]; other site 316275009452 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 5.1e-22 316275009453 PS00622 Bacterial regulatory proteins, luxR family signature. 316275009454 Predicted helix-turn-helix motif with score 1008.000, SD 2.62 at aa 167-188, sequence EKVTDISEQLNLSPKTVNSYRY 316275009455 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-43 316275009456 DNA polymerase II; Reviewed; Region: PRK05762 316275009457 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 316275009458 active site 316275009459 catalytic site [active] 316275009460 substrate binding site [chemical binding]; other site 316275009461 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 316275009462 active site 316275009463 metal-binding site 316275009464 HMMPfam hit to PF00136, DNA polymerase family B, score 9.7e-32 316275009465 PS00116 DNA polymerase family B signature. 316275009466 HMMPfam hit to PF03104, DNA polymerase family B, exonuclease do, score 6.4e-13 316275009467 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 316275009468 active site 316275009469 NTP binding site [chemical binding]; other site 316275009470 metal binding triad [ion binding]; metal-binding site 316275009471 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 316275009473 HMMPfam hit to PF03553, Na+/H+ antiporter family, score 5.1e-112 316275009474 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 316275009475 HMMPfam hit to PF00816, H-NS histone family, score 1.9e-42 316275009476 MltA-interacting protein MipA; Region: MipA; cl01504 316275009477 HMMPfam hit to PF06629, MltA-interacting protein MipA, score 3e-41 316275009478 fatty acid metabolism regulator; Provisional; Region: PRK04984 316275009479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316275009480 DNA-binding site [nucleotide binding]; DNA binding site 316275009481 FadR C-terminal domain; Region: FadR_C; pfam07840 316275009482 HMMPfam hit to PF07840, FadR C-terminal domain, score 1.3e-122 316275009483 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 316275009484 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 8.6e-24 316275009485 PS00043 Bacterial regulatory proteins, gntR family signature. 316275009486 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 316275009487 HMMPfam hit to PF06450, Bacterial Na+/H+ antiporter B (NhaB), score 0 316275009489 disulfide bond formation protein B; Provisional; Region: PRK01749 316275009490 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 1.8e-37 316275009492 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 316275009493 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 316275009494 SEC-C motif; Region: SEC-C; pfam02810 316275009495 HMMPfam hit to PF02810, SEC-C motif, score 0.00047 316275009496 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 4.5e-09 316275009497 PS00409 Prokaryotic N-terminal methylation site. 316275009499 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 316275009500 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 316275009501 FMN binding site [chemical binding]; other site 316275009502 active site 316275009503 catalytic residues [active] 316275009504 substrate binding site [chemical binding]; other site 316275009505 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 1.3e-99 316275009506 PS01136 Uncharacterized protein family UPF0034 signature. 316275009507 Cache domain; Region: Cache_1; pfam02743 316275009508 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275009509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275009510 metal binding site [ion binding]; metal-binding site 316275009511 active site 316275009512 I-site; other site 316275009513 HMMPfam hit to PF00990, GGDEF domain, score 1.3e-39 316275009515 DNA topoisomerase III; Provisional; Region: PRK07726 316275009516 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 316275009517 active site 316275009518 putative interdomain interaction site [polypeptide binding]; other site 316275009519 putative metal-binding site [ion binding]; other site 316275009520 putative nucleotide binding site [chemical binding]; other site 316275009521 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 316275009522 domain I; other site 316275009523 DNA binding groove [nucleotide binding] 316275009524 phosphate binding site [ion binding]; other site 316275009525 domain II; other site 316275009526 domain III; other site 316275009527 nucleotide binding site [chemical binding]; other site 316275009528 catalytic site [active] 316275009529 domain IV; other site 316275009530 HMMPfam hit to PF01131, DNA topoisomerase, score 1.5e-135 316275009531 PS00396 Prokaryotic DNA topoisomerase I active site. 316275009532 HMMPfam hit to PF01751, Toprim domain, score 7.9e-28 316275009533 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 316275009534 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 316275009535 active site 316275009536 FMN binding site [chemical binding]; other site 316275009537 2,4-decadienoyl-CoA binding site; other site 316275009538 catalytic residue [active] 316275009539 4Fe-4S cluster binding site [ion binding]; other site 316275009540 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 316275009541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316275009542 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0007 316275009543 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 0.0013 316275009544 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoredu, score 5e-05 316275009545 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 0.00097 316275009546 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 3.2e-111 316275009547 protease 4; Provisional; Region: PRK10949 316275009548 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 316275009549 tandem repeat interface [polypeptide binding]; other site 316275009550 oligomer interface [polypeptide binding]; other site 316275009551 active site residues [active] 316275009552 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 316275009553 tandem repeat interface [polypeptide binding]; other site 316275009554 oligomer interface [polypeptide binding]; other site 316275009555 active site residues [active] 316275009557 HMMPfam hit to PF01343, Peptidase family S49, score 2.5e-28 316275009558 HMMPfam hit to PF01343, Peptidase family S49, score 2e-62 316275009559 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 316275009560 active site 316275009561 homodimer interface [polypeptide binding]; other site 316275009562 HMMPfam hit to PF00710, Asparaginase, score 8.9e-138 316275009563 PS00455 AMP-binding domain signature. 316275009564 PS00144 Asparaginase / glutaminase active site signature 1. 316275009565 PS00917 Asparaginase / glutaminase active site signature 2. 316275009566 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 316275009567 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316275009568 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 2e-77 316275009569 PS01103 Aspartate-semialdehyde dehydrogenase signature. 316275009570 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 6.7e-36 316275009571 Similar to Bacillus subtilis Malate-2H(+)/Na(+)-lactate antiporter MleN UniProt:P54571 (468 aa) fasta scores: E()=1.8e-83, 58.444% id in 450 aa. CDS contains a frameshift after codon 148 and may be truncated by the insertion of the downstream IS element and subsequent recombination events. The sequence has been checked and is believed to be correct 316275009573 HMMPfam hit to PF03553, Na+/H+ antiporter family, score 1.1e-85 316275009574 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275009575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275009576 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275009577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275009578 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275009579 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275009580 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275009581 Similar to Escherichia coli Protease 3 precursor PtrA UniProt:P05458 (962 aa) fasta scores: E()=1.6e-69, 25.817% id in 887 aa. The insertion of the downstream IS element truncates the last 16 amino acid residues of the CDS. There is an inframe translational stop codon one amino acid residue further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275009582 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 3.4e-11 316275009583 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 3.9e-26 316275009584 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 8e-43 316275009585 PS00143 Insulinase family, zinc-binding region signature. 316275009586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 316275009587 catalytic core [active] 316275009588 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 7.9e-15 316275009589 hypothetical protein; Provisional; Region: PRK04946 316275009590 Smr domain; Region: Smr; pfam01713 316275009591 HMMPfam hit to PF01713, Smr domain, score 3.1e-32 316275009592 HemK family putative methylases; Region: hemK_fam; TIGR00536 316275009593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275009594 S-adenosylmethionine binding site [chemical binding]; other site 316275009595 HMMPfam hit to PF05175, Methyltransferase small domain, score 7.2e-09 316275009596 PS00092 N-6 Adenine-specific DNA methylases signature. 316275009597 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 316275009598 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 316275009599 Tetramer interface [polypeptide binding]; other site 316275009600 active site 316275009601 FMN-binding site [chemical binding]; other site 316275009602 HMMPfam hit to PF01264, Chorismate synthase, score 1.4e-236 316275009603 PS00787 Chorismate synthase signature 1. 316275009604 PS00217 Sugar transport proteins signature 2. 316275009605 PS00788 Chorismate synthase signature 2. 316275009606 PS00789 Chorismate synthase signature 3. 316275009607 Predicted membrane protein [Function unknown]; Region: COG2860 316275009608 UPF0126 domain; Region: UPF0126; pfam03458 316275009609 UPF0126 domain; Region: UPF0126; pfam03458 316275009610 HMMPfam hit to PF03458, UPF0126 domain, score 2.9e-32 316275009612 HMMPfam hit to PF03458, UPF0126 domain, score 1e-34 316275009613 MgtC family; Region: MgtC; pfam02308 316275009614 HMMPfam hit to PF02308, MgtC family, score 1.6e-17 316275009616 Protein of unknown function, DUF462; Region: DUF462; pfam04315 316275009617 HMMPfam hit to PF04315, Protein of unknown function, DUF462, score 2.3e-127 316275009618 YfcL protein; Region: YfcL; pfam08891 316275009619 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 316275009620 heme-binding site [chemical binding]; other site 316275009621 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275009622 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275009623 metal binding site [ion binding]; metal-binding site 316275009624 active site 316275009625 I-site; other site 316275009626 HMMPfam hit to PF00990, GGDEF domain, score 5.7e-47 316275009627 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 316275009628 HMMPfam hit to PF01230, HIT domain, score 8.3e-24 316275009629 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 316275009630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316275009631 putative acyl-acceptor binding pocket; other site 316275009632 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 7e-108 316275009634 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 316275009635 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 316275009636 Cl- selectivity filter; other site 316275009637 Cl- binding residues [ion binding]; other site 316275009638 pore gating glutamate residue; other site 316275009639 dimer interface [polypeptide binding]; other site 316275009640 H+/Cl- coupling transport residue; other site 316275009642 HMMPfam hit to PF00654, Voltage gated chloride channel, score 5.6e-86 316275009643 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275009644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275009645 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275009646 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275009647 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275009648 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275009649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275009650 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 316275009651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275009652 S-adenosylmethionine binding site [chemical binding]; other site 316275009653 HMMPfam hit to PF08241, Methyltransferase domain, score 1.8e-08 316275009654 HMMPfam hit to PF08242, Methyltransferase domain, score 3e-08 316275009655 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 316275009656 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 316275009657 trimer interface [polypeptide binding]; other site 316275009658 eyelet of channel; other site 316275009660 HMMPfam hit to PF00267, Gram-negative porin, score 0.00013 316275009661 hypothetical protein; Validated; Region: PRK05445 316275009662 HMMPfam hit to PF03887, YfbU domain, score 2.1e-96 316275009663 formate--tetrahydrofolate ligase; Provisional; Region: PRK13506 316275009664 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 316275009665 Potassium binding sites [ion binding]; other site 316275009666 Cesium cation binding sites [ion binding]; other site 316275009667 HMMPfam hit to PF01268, Formate--tetrahydrofolate ligase, score 1.7e-250 316275009668 PS00721 Formate--tetrahydrofolate ligase signature 1. 316275009669 PS00173 Xylose isomerase signature 2. 316275009670 Similar to Escherichia coli Sensor kinase DpiB UniProt:P77510 (552 aa) fasta scores: E()=1.2e-56, 35.359% id in 543 aa. CDS contains a nonsense mutation (AAA to TAA) after codon 384. The sequence has been checked and is believed to be correct 316275009672 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009673 HMMPfam hit to PF00989, PAS fold, score 2.3e-05 316275009674 HMMPfam hit to PF08448, PAS fold, score 0.0038 316275009675 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009676 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 4.2e-20 316275009677 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 316275009678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275009679 active site 316275009680 phosphorylation site [posttranslational modification] 316275009681 intermolecular recognition site; other site 316275009682 dimerization interface [polypeptide binding]; other site 316275009683 Transcriptional regulator; Region: CitT; pfam12431 316275009684 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.3e-25 316275009685 Predicted helix-turn-helix motif with score 1170.000, SD 3.17 at aa 176-197, sequence LTADQAGELFGASRTTARRYLE 316275009686 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 316275009687 putative deacylase active site [active] 316275009688 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associated do, score 3.1e-60 316275009689 hypothetical protein; Provisional; Region: PRK10279 316275009690 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 316275009691 active site 316275009692 nucleophile elbow; other site 316275009693 HMMPfam hit to PF01734, Patatin-like phospholipase, score 1.1e-41 316275009694 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 316275009695 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275009696 ATP binding site [chemical binding]; other site 316275009697 Mg++ binding site [ion binding]; other site 316275009698 motif III; other site 316275009699 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275009700 nucleotide binding region [chemical binding]; other site 316275009701 ATP-binding site [chemical binding]; other site 316275009702 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.4e-32 316275009703 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 1.1e-68 316275009704 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275009705 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 316275009708 HMMPfam hit to PF01970, Integral membrane protein DUF112, score 9e-209 316275009709 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275009710 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 316275009712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 316275009713 HMMPfam hit to PF03401, Bordetella uptake gene (bug) product, score 1.9e-08 316275009714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275009715 dimerization interface [polypeptide binding]; other site 316275009716 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275009717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275009718 dimer interface [polypeptide binding]; other site 316275009719 putative CheW interface [polypeptide binding]; other site 316275009720 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.1e-53 316275009721 HMMPfam hit to PF00672, HAMP domain, score 5.9e-15 316275009722 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009724 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275009725 adenylosuccinate lyase; Provisional; Region: PRK09285 316275009726 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 316275009727 tetramer interface [polypeptide binding]; other site 316275009728 active site 316275009729 HMMPfam hit to PF08328, Adenylosuccinate lyase C-terminal, score 2.1e-87 316275009730 HMMPfam hit to PF00206, Lyase, score 6.3e-89 316275009731 PS00163 Fumarate lyases signature. 316275009732 putative lysogenization regulator; Reviewed; Region: PRK00218 316275009733 HMMPfam hit to PF04356, Protein of unknown function (DUF489), score 1.4e-120 316275009734 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 316275009735 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 316275009736 HMMPfam hit to PF03054, tRNA methyl transferase, score 1.3e-210 316275009737 PS00070 Aldehyde dehydrogenases cysteine active site. 316275009738 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 316275009739 GAF domain; Region: GAF; pfam01590 316275009740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275009741 Walker A motif; other site 316275009742 ATP binding site [chemical binding]; other site 316275009743 Walker B motif; other site 316275009744 arginine finger; other site 316275009745 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275009746 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 3.5e-134 316275009747 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00016 316275009748 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275009749 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 316275009750 HMMPfam hit to PF01590, GAF domain, score 1.7e-09 316275009751 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 316275009752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316275009753 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 316275009754 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 316275009755 iron binding site [ion binding]; other site 316275009756 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 8.8e-27 316275009757 HMMPfam hit to PF00258, Flavodoxin, score 5e-20 316275009758 HMMPfam hit to PF00301, Rubredoxin, score 5.8e-17 316275009759 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 316275009760 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275009761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275009762 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 1.1e-31 316275009763 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 4.7e-18 316275009764 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 316275009765 ferredoxin-NADP reductase; Provisional; Region: PRK10926 316275009766 FAD binding pocket [chemical binding]; other site 316275009767 FAD binding motif [chemical binding]; other site 316275009768 phosphate binding motif [ion binding]; other site 316275009769 beta-alpha-beta structure motif; other site 316275009770 NAD binding pocket [chemical binding]; other site 316275009771 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 4.8e-09 316275009772 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 316275009773 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 316275009774 pseudouridine synthase; Region: TIGR00093 316275009775 active site 316275009776 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 3.5e-31 316275009777 PS01149 Rsu family of pseudouridine synthase signature. 316275009778 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 316275009779 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 316275009780 HMMPfam hit to PF03971, Monomeric isocitrate dehydrogenase, score 0 316275009781 SpoVR family protein; Provisional; Region: PRK11767 316275009782 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 316275009783 HMMPfam hit to PF04293, SpoVR like protein, score 0 316275009784 hypothetical protein; Provisional; Region: PRK05325 316275009785 HMMPfam hit to PF04285, Protein of unknown function (DUF444), score 3.2e-251 316275009786 PrkA family serine protein kinase; Provisional; Region: PRK15455 316275009787 AAA ATPase domain; Region: AAA_16; pfam13191 316275009788 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 316275009789 HMMPfam hit to PF06798, PrkA serine protein kinase C-terminal domain, score 1.4e-166 316275009790 HMMPfam hit to PF08298, PrkA AAA domain, score 3.8e-246 316275009791 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009792 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 316275009793 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 316275009794 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 316275009795 homodimer interface [polypeptide binding]; other site 316275009796 NADP binding site [chemical binding]; other site 316275009797 substrate binding site [chemical binding]; other site 316275009798 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 2e-107 316275009799 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 316275009800 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 4.8e-71 316275009801 PS00766 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. 316275009802 Uncharacterized conserved protein [Function unknown]; Region: COG0397 316275009803 hypothetical protein; Validated; Region: PRK00029 316275009804 HMMPfam hit to PF02696, Uncharacterized ACR, YdiU/UPF0061 family, score 1e-131 316275009805 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 316275009806 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275009807 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316275009808 DNA-binding site [nucleotide binding]; DNA binding site 316275009809 RNA-binding motif; other site 316275009810 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 6.1e-36 316275009811 PS00352 'Cold-shock' DNA-binding domain signature. 316275009812 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 316275009813 HMMPfam hit to PF02617, ATP-dependent Clp protease adaptor protein C, score 7.3e-50 316275009814 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 316275009815 Clp amino terminal domain; Region: Clp_N; pfam02861 316275009816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275009817 Walker A motif; other site 316275009818 ATP binding site [chemical binding]; other site 316275009819 Walker B motif; other site 316275009820 arginine finger; other site 316275009821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275009822 Walker A motif; other site 316275009823 ATP binding site [chemical binding]; other site 316275009824 Walker B motif; other site 316275009825 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 316275009826 HMMPfam hit to PF02861, Clp amino terminal domain, score 2.4e-11 316275009827 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.1e-12 316275009828 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009829 PS00870 Chaperonins clpA/B signature 1. 316275009830 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 5.7e-90 316275009831 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 1.6e-05 316275009832 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009833 PS00871 Chaperonins clpA/B signature 2. 316275009834 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 316275009835 rRNA binding site [nucleotide binding]; other site 316275009836 predicted 30S ribosome binding site; other site 316275009837 HMMPfam hit to PF00575, S1 RNA binding domain, score 8.7e-10 316275009838 HMMPfam hit to PF01176, Translation initiation factor 1A / IF-1, score 1.5e-35 316275009839 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 316275009840 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 316275009841 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 316275009842 HMMPfam hit to PF04377, Arginine-tRNA-protein transferase, C terminu, score 1.2e-44 316275009843 HMMPfam hit to PF04376, Arginine-tRNA-protein transferase, N terminu, score 7.1e-28 316275009844 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 316275009845 HMMPfam hit to PF03588, Leucyl/phenylalanyl-tRNA protein transf, score 1.1e-85 316275009846 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 316275009847 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 316275009848 hinge; other site 316275009849 active site 316275009850 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 1e-216 316275009851 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009852 PS00104 EPSP synthase signature 1. 316275009853 PS00885 EPSP synthase signature 2. 316275009854 cytidylate kinase; Provisional; Region: cmk; PRK00023 316275009855 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 316275009856 CMP-binding site; other site 316275009857 The sites determining sugar specificity; other site 316275009858 HMMPfam hit to PF02224, Cytidylate kinase, score 5.1e-73 316275009859 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 316275009860 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 316275009861 RNA binding site [nucleotide binding]; other site 316275009862 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 316275009863 RNA binding site [nucleotide binding]; other site 316275009864 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 316275009865 RNA binding site [nucleotide binding]; other site 316275009866 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 316275009867 RNA binding site [nucleotide binding]; other site 316275009868 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316275009869 RNA binding site [nucleotide binding]; other site 316275009870 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 316275009871 RNA binding site [nucleotide binding]; other site 316275009872 HMMPfam hit to PF00575, S1 RNA binding domain, score 1.6e-13 316275009873 HMMPfam hit to PF00575, S1 RNA binding domain, score 3e-17 316275009874 HMMPfam hit to PF00575, S1 RNA binding domain, score 4.5e-31 316275009875 HMMPfam hit to PF00575, S1 RNA binding domain, score 4.6e-30 316275009876 HMMPfam hit to PF00575, S1 RNA binding domain, score 7.7e-26 316275009877 HMMPfam hit to PF00575, S1 RNA binding domain, score 2.7e-15 316275009878 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316275009879 IHF dimer interface [polypeptide binding]; other site 316275009880 IHF - DNA interface [nucleotide binding]; other site 316275009881 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 5.6e-44 316275009882 PS00045 Bacterial histone-like DNA-binding proteins signature. 316275009883 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 316275009884 HMMPfam hit to PF06305, Protein of unknown function (DUF1049), score 2.5e-38 316275009886 tetratricopeptide repeat protein; Provisional; Region: PRK11788 316275009887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275009888 TPR motif; other site 316275009889 binding surface 316275009890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275009891 binding surface 316275009892 TPR motif; other site 316275009893 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 316275009894 active site 316275009895 dimer interface [polypeptide binding]; other site 316275009896 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase / HUMP, score 1.1e-86 316275009897 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 316275009898 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 316275009899 active site 316275009900 HIGH motif; other site 316275009901 KMSKS motif; other site 316275009902 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 316275009903 tRNA binding surface [nucleotide binding]; other site 316275009904 anticodon binding site; other site 316275009905 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 316275009906 dimer interface [polypeptide binding]; other site 316275009907 putative tRNA-binding site [nucleotide binding]; other site 316275009908 HMMPfam hit to PF01588, tRNA binding domain, score 1.3e-44 316275009909 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275009910 antiporter inner membrane protein; Provisional; Region: PRK11670 316275009911 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 316275009912 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009913 PS01215 Mrp family signature. 316275009914 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 316275009915 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 316275009916 ATP-binding site [chemical binding]; other site 316275009917 Sugar specificity; other site 316275009918 Pyrimidine base specificity; other site 316275009919 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 1.2e-43 316275009920 PS00017 ATP/GTP-binding site motif A (P-loop). 316275009921 AsmA family; Region: AsmA; pfam05170 316275009922 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 316275009923 HMMPfam hit to PF05170, AsmA family, score 6.8e-57 316275009925 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 316275009926 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 316275009927 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 316275009928 homodimer interface [polypeptide binding]; other site 316275009929 Walker A motif; other site 316275009930 ATP binding site [chemical binding]; other site 316275009931 hydroxycobalamin binding site [chemical binding]; other site 316275009932 Walker B motif; other site 316275009933 HMMPfam hit to PF02572, ATP:corrinoid adenosyltransferase BtuR, score 3.9e-82 316275009934 HAMP domain; Region: HAMP; pfam00672 316275009935 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275009936 Zn2+ binding site [ion binding]; other site 316275009937 Mg2+ binding site [ion binding]; other site 316275009939 HMMPfam hit to PF00672, HAMP domain, score 0.00046 316275009940 HMMPfam hit to PF01966, HD domain, score 3e-20 316275009941 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 316275009942 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 316275009943 Sulfate transporter family; Region: Sulfate_transp; pfam00916 316275009944 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 316275009945 HMMPfam hit to PF01740, STAS domain, score 0.002 316275009946 HMMPfam hit to PF00916, Sulfate transporter family, score 2.4e-72 316275009948 HMMPfam hit to PF00860, Permease family, score 0.00032 316275009949 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 316275009950 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 316275009951 homodimer interface [polypeptide binding]; other site 316275009952 oligonucleotide binding site [chemical binding]; other site 316275009953 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.3e-16 316275009954 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 316275009955 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275009956 RNA binding surface [nucleotide binding]; other site 316275009957 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316275009958 active site 316275009959 HMMPfam hit to PF01479, S4 domain, score 1e-11 316275009960 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.2e-51 316275009961 PS01129 Rlu family of pseudouridine synthase signature. 316275009962 Maf-like protein; Region: Maf; pfam02545 316275009963 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 316275009964 active site 316275009965 dimer interface [polypeptide binding]; other site 316275009966 HMMPfam hit to PF02545, Maf-like protein, score 2.5e-62 316275009967 hypothetical protein; Provisional; Region: PRK11193 316275009968 HMMPfam hit to PF02620, Uncharacterized ACR, COG1399, score 2.9e-42 316275009969 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 316275009970 HMMPfam hit to PF01783, Ribosomal L32p protein family, score 8e-21 316275009971 putative phosphate acyltransferase; Provisional; Region: PRK05331 316275009972 HMMPfam hit to PF02504, Fatty acid synthesis protein, score 2.4e-122 316275009973 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 316275009974 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 316275009975 dimer interface [polypeptide binding]; other site 316275009976 active site 316275009977 CoA binding pocket [chemical binding]; other site 316275009978 HMMPfam hit to PF08545, 3-Oxoacyl-[acyl-carrier-protein (ACP)], score 7.2e-48 316275009979 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)], score 4.8e-53 316275009980 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 316275009981 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 316275009982 HMMPfam hit to PF00698, Acyl transferase domain, score 4.7e-12 316275009983 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 316275009984 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 316275009985 NAD(P) binding site [chemical binding]; other site 316275009986 homotetramer interface [polypeptide binding]; other site 316275009987 homodimer interface [polypeptide binding]; other site 316275009988 active site 316275009989 HMMPfam hit to PF00106, short chain dehydrogenase, score 6.5e-41 316275009990 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase family, score 0.0034 316275009991 PS00061 Short-chain dehydrogenases/reductases family signature. 316275009992 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 316275009993 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722 316275009994 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 316275009995 dimer interface [polypeptide binding]; other site 316275009996 active site 316275009997 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal do, score 2.3e-81 316275009998 PS00606 Beta-ketoacyl synthases active site. 316275009999 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal do, score 7e-67 316275010000 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 316275010001 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 316275010002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275010003 catalytic residue [active] 316275010004 HMMPfam hit to PF01063, Aminotransferase class IV, score 1.1e-27 316275010005 PS00770 Aminotransferases class-IV signature. 316275010006 YceG-like family; Region: YceG; pfam02618 316275010007 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 316275010008 dimerization interface [polypeptide binding]; other site 316275010010 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 9.4e-136 316275010011 thymidylate kinase; Validated; Region: tmk; PRK00698 316275010012 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 316275010013 TMP-binding site; other site 316275010014 ATP-binding site [chemical binding]; other site 316275010015 HMMPfam hit to PF02223, Thymidylate kinase, score 9e-71 316275010016 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010017 PS01331 Thymidylate kinase signature. 316275010018 DNA polymerase III subunit delta'; Validated; Region: PRK06090 316275010019 DNA polymerase III subunit delta'; Validated; Region: PRK08485 316275010020 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 316275010021 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 316275010022 active site 316275010023 HMMPfam hit to PF01026, TatD related DNase, score 5.7e-113 316275010024 HMMPfam hit to PF01026, TatD related DNase, score 9.9e-06 316275010025 PS01137 Uncharacterized protein family UPF0006 signature 1. 316275010026 HMMPfam hit to PF01026, TatD related DNase, score 1.2e-26 316275010027 PS01090 Uncharacterized protein family UPF0006 signature 2. 316275010028 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275010029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275010030 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275010031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275010032 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275010033 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275010034 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275010035 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275010036 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275010037 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275010038 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 316275010039 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 316275010040 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 316275010041 active site turn [active] 316275010042 phosphorylation site [posttranslational modification] 316275010044 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 6.1e-86 316275010045 HMMPfam hit to PF00367, phosphotransferase system, EIIB, score 1.2e-12 316275010046 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 316275010047 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 316275010048 putative GSH binding site (G-site) [chemical binding]; other site 316275010049 active site cysteine [active] 316275010050 putative C-terminal domain interface [polypeptide binding]; other site 316275010051 putative dimer interface [polypeptide binding]; other site 316275010052 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 316275010053 putative N-terminal domain interface [polypeptide binding]; other site 316275010054 putative dimer interface [polypeptide binding]; other site 316275010055 putative substrate binding pocket (H-site) [chemical binding]; other site 316275010056 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 316275010057 Na2 binding site [ion binding]; other site 316275010058 putative substrate binding site 1 [chemical binding]; other site 316275010059 Na binding site 1 [ion binding]; other site 316275010060 putative substrate binding site 2 [chemical binding]; other site 316275010061 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 1.5e-88 316275010063 PS00610 Sodium:neurotransmitter symporter family signature 1. 316275010064 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275010065 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E6L9 (1135 aa) fasta scores: E()=0, 63.996% id in 1136 aa. CDS contains a frameshift after codon 274. The sequence has been checked and is believed to be correct 316275010066 HMMPfam hit to PF07494, Two component regulator propeller, score 11 316275010067 HMMPfam hit to PF07494, Two component regulator propeller, score 0.0054 316275010068 HMMPfam hit to PF07494, Two component regulator propeller, score 9.2 316275010069 HMMPfam hit to PF07494, Two component regulator propeller, score 16 316275010070 HMMPfam hit to PF07494, Two component regulator propeller, score 22 316275010071 HMMPfam hit to PF07494, Two component regulator propeller, score 9.8 316275010073 Predicted helix-turn-helix motif with score 1219.000, SD 3.34 at aa 713-734, sequence FGTSAAAKLLYTSERNLQRKFK 316275010074 PS00041 Bacterial regulatory proteins, araC family signature. 316275010075 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.8e-07 316275010076 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 316275010077 HMMPfam hit to PF04023, FeoA domain, score 2.2e-25 316275010078 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 316275010079 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 316275010080 G1 box; other site 316275010081 GTP/Mg2+ binding site [chemical binding]; other site 316275010082 Switch I region; other site 316275010083 G2 box; other site 316275010084 G3 box; other site 316275010085 Switch II region; other site 316275010086 G4 box; other site 316275010087 G5 box; other site 316275010088 Nucleoside recognition; Region: Gate; pfam07670 316275010089 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 316275010090 Nucleoside recognition; Region: Gate; pfam07670 316275010091 HMMPfam hit to PF01926, GTPase of unknown function, score 4.3e-36 316275010092 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010093 HMMPfam hit to PF02421, Ferrous iron transport protein B, score 1.8e-42 316275010095 HMMPfam hit to PF07670, Nucleoside recognition, score 4.4e-16 316275010096 HMMPfam hit to PF07664, Ferrous iron transport protein B C terminus, score 1e-22 316275010097 HMMPfam hit to PF07670, Nucleoside recognition, score 9.9e-15 316275010098 FeoC like transcriptional regulator; Region: FeoC; pfam09012 316275010099 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275010100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275010101 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275010102 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275010103 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275010104 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275010105 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275010106 Similar to Vibrio fischeri Hypothetical phage protein UniProt:Q5E397 (628 aa) fasta scores: E()=1.6e-20, 32.743% id in 226 aa. CDS is truncated by the insertion of the downstream and upstream IS elements and subsequent recombination events 316275010107 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275010108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275010109 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275010110 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275010111 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275010112 Similar to Pseudoalteromonas haloplanktis transposase UniProt:Q3IIG1 (115 aa) fasta scores: E()=1.2e-13, 37.4% id in 115 aa. CDS contains a frameshift after codon 70 316275010113 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 5.3e-37 316275010114 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 316275010115 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 5.1e-67 316275010116 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 2.4e-58 316275010117 PS00166 Enoyl-CoA hydratase/isomerase signature. 316275010118 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 316275010119 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316275010120 dimer interface [polypeptide binding]; other site 316275010121 active site 316275010122 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 1e-47 316275010123 PS00737 Thiolases signature 2. 316275010124 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 5.2e-65 316275010125 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 316275010126 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 5.3e-131 316275010127 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 316275010128 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 1.8e-148 316275010129 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 316275010131 VacJ like lipoprotein; Region: VacJ; cl01073 316275010132 HMMPfam hit to PF04333, VacJ like lipoprotein, score 1.1e-93 316275010133 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275010134 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 316275010135 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 316275010136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275010137 binding surface 316275010138 TPR motif; other site 316275010140 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 316275010141 HMMPfam hit to PF03918, Cytochrome C biogenesis protein, score 1.3e-61 316275010143 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 316275010144 catalytic residues [active] 316275010145 central insert; other site 316275010146 HMMPfam hit to PF08534, Redoxin, score 2.3e-34 316275010147 PS00194 Thioredoxin family active site. 316275010149 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 316275010151 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 6.6e-87 316275010152 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 316275010153 HMMPfam hit to PF03100, CcmE, score 1.1e-78 316275010155 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 316275010156 HMMPfam hit to PF04995, Heme exporter protein D (CcmD), score 8.9e-13 316275010158 heme exporter protein CcmC; Region: ccmC; TIGR01191 316275010160 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 7.9e-60 316275010161 HMMPfam hit to PF01578, Cytochrome C assembly protein, score 1.3e-15 316275010162 heme exporter protein CcmB; Region: ccmB; TIGR01190 316275010163 HMMPfam hit to PF03379, CcmB protein, score 1.6e-121 316275010165 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 316275010166 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 316275010167 Walker A/P-loop; other site 316275010168 ATP binding site [chemical binding]; other site 316275010169 Q-loop/lid; other site 316275010170 ABC transporter signature motif; other site 316275010171 Walker B; other site 316275010172 D-loop; other site 316275010173 H-loop/switch region; other site 316275010174 HMMPfam hit to PF00005, ABC transporter score 6.2e-39 316275010175 PS00211 ABC transporters family signature. 316275010176 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010177 Protein of unknown function (DUF2802); Region: DUF2802; pfam10975 316275010179 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 316275010180 putative CheA interaction surface; other site 316275010181 HMMPfam hit to PF01584, CheW-like domain, score 1.5e-33 316275010182 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 316275010183 HMMPfam hit to PF01584, CheW-like domain, score 1.1e-23 316275010184 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316275010185 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316275010186 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275010187 Magnesium ion binding site [ion binding]; other site 316275010188 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 8.4e-34 316275010189 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 316275010190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275010191 active site 316275010192 phosphorylation site [posttranslational modification] 316275010193 intermolecular recognition site; other site 316275010194 CheB methylesterase; Region: CheB_methylest; pfam01339 316275010195 HMMPfam hit to PF01339, CheB methylesterase, score 5.8e-77 316275010196 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.2e-26 316275010197 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 316275010198 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316275010199 putative binding surface; other site 316275010200 active site 316275010201 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 316275010202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275010203 ATP binding site [chemical binding]; other site 316275010204 Mg2+ binding site [ion binding]; other site 316275010205 G-X-G motif; other site 316275010206 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 316275010207 HMMPfam hit to PF01584, CheW-like domain, score 1.6e-21 316275010208 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.8e-26 316275010209 HMMPfam hit to PF02895, Signal transducing histidine kinase, hom, score 7.6e-22 316275010210 HMMPfam hit to PF01627, Hpt domain, score 1.3e-12 316275010211 Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344 316275010212 HMMPfam hit to PF04344, Chemotaxis phosphatase, CheZ, score 1.7e-121 316275010213 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 316275010214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275010215 active site 316275010216 phosphorylation site [posttranslational modification] 316275010217 intermolecular recognition site; other site 316275010218 dimerization interface [polypeptide binding]; other site 316275010219 HMMPfam hit to PF00072, Response regulator receiver domain, score 7.5e-42 316275010220 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 316275010221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316275010222 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316275010223 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316275010224 DNA binding residues [nucleotide binding] 316275010225 HMMPfam hit to PF04545, Sigma-70, region, score 4.2e-20 316275010226 HMMPfam hit to PF08281, Sigma-70, region, score 2.5e-08 316275010227 PS00716 Sigma-70 factors family signature 2. 316275010228 Predicted helix-turn-helix motif with score 1576.000, SD 4.55 at aa 206-227, sequence LNLKEIGAVIGVSESRVSQIHS 316275010229 HMMPfam hit to PF04539, Sigma-70 region, score 7.3e-12 316275010230 PS00018 EF-hand calcium-binding domain. 316275010231 HMMPfam hit to PF04542, Sigma-70 region, score 2.2e-16 316275010232 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316275010233 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 316275010234 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 316275010235 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 2.7e-18 316275010236 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010237 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 316275010238 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 316275010239 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 3.6e-30 316275010240 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010241 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 316275010242 FHIPEP family; Region: FHIPEP; pfam00771 316275010243 HMMPfam hit to PF00771, FHIPEP family, score 0 316275010245 PS00994 Bacterial export FHIPEP family signature. 316275010246 Flagellar protein YcgR; Region: YcgR_2; pfam12945 316275010247 PilZ domain; Region: PilZ; pfam07238 316275010248 HMMPfam hit to PF07238, PilZ domain, score 3.4e-14 316275010249 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 316275010250 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 316275010251 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family, score 1.1e-116 316275010253 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 316275010254 HMMPfam hit to PF01311, Bacterial export proteins, family, score 1.7e-24 316275010256 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 316275010258 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 316275010259 HMMPfam hit to PF00813, FliP family, score 1.3e-102 316275010261 PS01061 Flagella transport protein fliP family signature 2. 316275010262 PS01060 Flagella transport protein fliP family signature 1. 316275010263 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 316275010264 HMMPfam hit to PF04347, Flagellar biosynthesis protein, FliO, score 6.9e-33 316275010266 flagellar motor switch protein; Validated; Region: fliN; PRK08983 316275010267 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 7.8e-33 316275010268 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 316275010269 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 316275010270 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 2e-19 316275010271 HMMPfam hit to PF02154, Flagellar motor switch protein FliM, score 5.1e-126 316275010272 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696 316275010273 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 2.2e-33 316275010275 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 316275010276 HMMPfam hit to PF02120, Flagellar hook-length control protein, score 8.7e-34 316275010277 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 316275010278 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 316275010279 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972 316275010280 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 316275010281 Walker A motif/ATP binding site; other site 316275010282 Walker B motif; other site 316275010283 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleotid, score 1.8e-121 316275010284 PS00152 ATP synthase alpha and beta subunits signature. 316275010285 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010286 flagellar assembly protein H; Validated; Region: fliH; PRK05687 316275010287 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 316275010288 Flagellar assembly protein FliH; Region: FliH; pfam02108 316275010289 HMMPfam hit to PF02108, Flagellar assembly protein FliH, score 4e-80 316275010290 Predicted helix-turn-helix motif with score 1052.000, SD 2.77 at aa 51-72, sequence LPKEEVAEEFVLTDEIIEQIKQ 316275010291 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 316275010292 MgtE intracellular N domain; Region: MgtE_N; smart00924 316275010293 FliG C-terminal domain; Region: FliG_C; pfam01706 316275010294 HMMPfam hit to PF01706, FliG C-terminal domain, score 1.9e-49 316275010295 Similar to Vibrio parahaemolyticus Polar flagellar M-ring protein FliF UniProt:Q9Z6G8 (580 aa) fasta scores: E()=3.1e-156, 70.121% id in 579 aa. CDS contains a nonsense mutation (GAA to TAA) after codon 218. The sequence has been checked and is believed to be correct 316275010296 HMMPfam hit to PF08345, Flagellar M-ring protein C-terminal, score 3.7e-72 316275010297 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 4.6e-26 316275010298 PS00430 TonB-dependent receptor proteins signature 1. 316275010300 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 316275010301 HMMPfam hit to PF02049, Flagellar hook-basal body complex protein Fl, score 7.8e-23 316275010302 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316275010303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275010304 active site 316275010305 phosphorylation site [posttranslational modification] 316275010306 intermolecular recognition site; other site 316275010307 dimerization interface [polypeptide binding]; other site 316275010308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275010309 Walker A motif; other site 316275010310 ATP binding site [chemical binding]; other site 316275010311 Walker B motif; other site 316275010312 arginine finger; other site 316275010313 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316275010314 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 2e-12 316275010315 Predicted helix-turn-helix motif with score 2177.000, SD 6.60 at aa 446-467, sequence GKRKEVAEKLGISPRTLRYKLA 316275010316 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275010317 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 2.6e-139 316275010318 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275010319 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.9e-36 316275010320 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316275010321 PAS domain; Region: PAS_8; pfam13188 316275010322 putative active site [active] 316275010323 heme pocket [chemical binding]; other site 316275010324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275010325 dimer interface [polypeptide binding]; other site 316275010326 phosphorylation site [posttranslational modification] 316275010327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275010328 ATP binding site [chemical binding]; other site 316275010329 G-X-G motif; other site 316275010330 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.5e-33 316275010331 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 9.3e-13 316275010332 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316275010333 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 316275010334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275010335 Walker A motif; other site 316275010336 ATP binding site [chemical binding]; other site 316275010337 Walker B motif; other site 316275010338 arginine finger; other site 316275010339 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316275010340 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 6.7e-15 316275010341 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275010342 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.2e-154 316275010343 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00052 316275010344 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275010345 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 316275010346 HMMPfam hit to PF06490, Flagellar regulatory protein FleQ, score 9.4e-33 316275010347 flagellar protein FliS; Validated; Region: fliS; PRK05685 316275010348 HMMPfam hit to PF02561, Flagellar protein FliS, score 7.2e-26 316275010349 flagellar capping protein; Validated; Region: fliD; PRK08724 316275010350 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 316275010351 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 316275010352 HMMPfam hit to PF07195, Flagellar hook-associated protein, score 5.4e-64 316275010353 HMMPfam hit to PF07196, Flagellin hook IN motif, score 5.9e-06 316275010354 HMMPfam hit to PF02465, Flagellar hook-associated protein, score 1.1e-30 316275010355 Similar to Vibrio parahaemolyticus Protein FlaG UniProt:Q56704 (144 aa) fasta scores: E()=1e-08, 33.813% id in 139 aa. CDS contains a nonsense mutation (TAA) after codon 69. The sequence has been checked and is believed to be correct 316275010356 HMMPfam hit to PF03646, FlaG protein, score 1.6e-18 316275010357 flagellin; Reviewed; Region: PRK08869 316275010358 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316275010359 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 316275010360 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 316275010361 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 1.4e-32 316275010362 HMMPfam hit to PF07196, Flagellin hook IN motif, score 6.3e-11 316275010363 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.3e-69 316275010364 flagellin; Reviewed; Region: PRK08869 316275010365 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316275010366 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 316275010367 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 316275010368 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 4.7e-29 316275010369 HMMPfam hit to PF07196, Flagellin hook IN motif, score 1.6e-11 316275010370 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.5e-72 316275010371 flagellin; Reviewed; Region: PRK08869 316275010372 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316275010373 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 316275010374 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 316275010375 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 5.4e-30 316275010376 HMMPfam hit to PF07196, Flagellin hook IN motif, score 2.5e-07 316275010377 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 4e-73 316275010378 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=6e-120, 57.143% id in 490 aa. CDS contains a frameshift after codon 327 316275010379 Similar to Pseudoalteromonas haloplanktis transposase UniProt:Q3IIG1 (115 aa) fasta scores: E()=1.3e-22, 56.3% id in 87 aa. CDS is truncated by the insertion of the upstream IS element 316275010380 HMMPfam hit to PF05717, IS66 Orf2 like protein, score 1.1e-13 316275010381 Similar to Shewanella denitrificans Transposase, IS4 family UniProt:Q12IQ1 (295 aa) fasta scores: E()=3.7e-75, 60.1% id in 291 aa. CDS is disruptet by the insertion of an IS element after codon 81 316275010382 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275010383 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275010384 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275010385 flagellin; Reviewed; Region: PRK08869 316275010386 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316275010387 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 316275010388 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 316275010389 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 4.4e-29 316275010390 HMMPfam hit to PF07196, Flagellin hook IN motif, score 1.4e-13 316275010391 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 2.9e-70 316275010392 flagellin; Reviewed; Region: PRK08869 316275010393 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316275010394 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 316275010395 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 316275010396 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 1.9e-29 316275010397 HMMPfam hit to PF07196, Flagellin hook IN motif, score 3.6e-11 316275010398 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.9e-71 316275010399 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 316275010400 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316275010401 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 0.00028 316275010402 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871 316275010403 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316275010404 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 5e-18 316275010405 PS00147 Arginase family signature 1. 316275010406 HMMPfam hit to PF00460, Flagella basal body rod protein, score 0.00013 316275010407 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 316275010408 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 316275010409 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 316275010410 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-ace, score 6.8e-45 316275010411 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 316275010412 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 316275010413 HMMPfam hit to PF02119, Flagellar P-ring protein, score 2.2e-221 316275010414 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010415 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 316275010416 HMMPfam hit to PF02107, Flagellar L-ring protein, score 1e-40 316275010417 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 316275010418 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316275010419 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316275010420 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 7.8e-18 316275010421 HMMPfam hit to PF00460, Flagella basal body rod protein, score 2.7e-13 316275010422 PS00588 Flagella basal body rod proteins signature. 316275010423 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 316275010424 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316275010425 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 7.8e-06 316275010426 PS00588 Flagella basal body rod proteins signature. 316275010427 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 316275010428 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 316275010429 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316275010430 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 3.5e-13 316275010431 HMMPfam hit to PF07559, Flagellar basal body protein FlaE, score 3.2e-25 316275010432 HMMPfam hit to PF00460, Flagella basal body rod protein, score 3.3e-10 316275010433 PS00588 Flagella basal body rod proteins signature. 316275010434 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 316275010435 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 316275010436 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 316275010437 HMMPfam hit to PF03963, Flagellar hook capping protein, score 7.6e-46 316275010438 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631 316275010439 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 316275010440 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 316275010441 HMMPfam hit to PF06429, Domain of unknown function (DUF1078), score 4.7e-12 316275010442 HMMPfam hit to PF00460, Flagella basal body rod protein, score 9.1e-05 316275010443 PS00588 Flagella basal body rod proteins signature. 316275010444 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 316275010445 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 316275010446 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 316275010447 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 316275010448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275010449 HMMPfam hit to PF01739, CheR methyltransferase, SAM binding d, score 3.3e-92 316275010450 HMMPfam hit to PF08242, Methyltransferase domain, score 0.00036 316275010451 HMMPfam hit to PF03705, CheR methyltransferase, all-alpha dom, score 1.2e-11 316275010452 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 316275010453 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316275010454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275010455 active site 316275010456 phosphorylation site [posttranslational modification] 316275010457 intermolecular recognition site; other site 316275010458 dimerization interface [polypeptide binding]; other site 316275010459 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.9e-18 316275010460 HMMPfam hit to PF01584, CheW-like domain, score 3.3e-25 316275010461 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 316275010462 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 316275010463 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 316275010465 HMMPfam hit to PF03240, FlgA family, score 1.1e-39 316275010466 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 316275010467 HMMPfam hit to PF04316, Anti-sigma-28 factor, FlgM, score 3.6e-22 316275010468 FlgN protein; Region: FlgN; cl09176 316275010469 HMMPfam hit to PF05130, FlgN protein, score 4.7e-36 316275010470 LPP20 lipoprotein; Region: LPP20; cl15824 316275010471 HMMPfam hit to PF04164, Protein of unknown function, DUF400, score 2.2e-38 316275010472 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275010473 Predicted integral membrane protein [Function unknown]; Region: COG5616 316275010474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275010475 binding surface 316275010476 TPR motif; other site 316275010477 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316275010478 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316275010479 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275010480 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275010481 metal binding site [ion binding]; metal-binding site 316275010482 active site 316275010483 I-site; other site 316275010484 Predicted helix-turn-helix motif with score 1366.000, SD 3.84 at aa 1-22, sequence MGRFEAALESHLSYEVLQQWIN 316275010486 HMMPfam hit to PF00990, GGDEF domain, score 7e-27 316275010487 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 316275010488 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 316275010489 active site 316275010490 HIGH motif; other site 316275010491 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 316275010492 active site 316275010493 KMSKS motif; other site 316275010494 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 1.6e-157 316275010495 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275010496 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275010497 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 316275010498 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 316275010499 nucleotide binding pocket [chemical binding]; other site 316275010500 K-X-D-G motif; other site 316275010501 catalytic site [active] 316275010502 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 316275010503 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 316275010504 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 316275010505 Dimer interface [polypeptide binding]; other site 316275010506 BRCT sequence motif; other site 316275010507 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 1.1e-16 316275010508 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 0.0014 316275010509 HMMPfam hit to PF03119, NAD-dependent DNA ligase C4 zinc fing, score 2.8e-13 316275010510 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 9.2e-50 316275010511 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 1.1e-181 316275010512 PS01055 NAD-dependent DNA ligase signature 1. 316275010513 cell division protein ZipA; Provisional; Region: PRK04335 316275010514 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 316275010515 FtsZ protein binding site [polypeptide binding]; other site 316275010516 HMMPfam hit to PF04354, ZipA, C-terminal FtsZ-binding domain, score 1.7e-66 316275010518 putative sulfate transport protein CysZ; Validated; Region: PRK04949 316275010520 HMMPfam hit to PF04401, Protein of unknown function (DUF540), score 1.1e-94 316275010521 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 316275010522 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 316275010523 dimer interface [polypeptide binding]; other site 316275010524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275010525 catalytic residue [active] 316275010526 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 1.4e-121 316275010527 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 316275010528 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316275010529 dimerization domain swap beta strand [polypeptide binding]; other site 316275010530 regulatory protein interface [polypeptide binding]; other site 316275010531 active site 316275010532 regulatory phosphorylation site [posttranslational modification]; other site 316275010533 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 5.5e-43 316275010534 PS00369 PTS HPR component histidine phosphorylation site signature. 316275010535 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 316275010536 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 316275010537 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 316275010538 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 316275010539 HMMPfam hit to PF05524, PEP-utilising enzyme, N-terminal, score 1.3e-53 316275010540 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile domain, score 6.1e-34 316275010541 PS00370 PEP-utilizing enzymes phosphorylation site signature. 316275010542 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 7.7e-182 316275010543 PS00742 PEP-utilizing enzymes signature 2. 316275010544 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 316275010545 HPr interaction site; other site 316275010546 glycerol kinase (GK) interaction site [polypeptide binding]; other site 316275010547 active site 316275010548 phosphorylation site [posttranslational modification] 316275010549 HMMPfam hit to PF00358, phosphoenolpyruvate-dependent sugar phosph, score 9.9e-78 316275010550 PS00371 PTS EIIA domains phosphorylation site signature 1. 316275010551 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 316275010552 HMMPfam hit to PF04261, Dyp-type peroxidase family, score 1.1e-118 316275010553 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 316275010555 Protein of unknown function (DUF2956); Region: DUF2956; pfam11169 316275010557 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 316275010558 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 316275010559 HMMPfam hit to PF03264, NapC/NirT cytochrome c family, N-termin, score 1.1e-83 316275010560 PS00190 Cytochrome c family heme-binding site signature. 316275010561 PS00190 Cytochrome c family heme-binding site signature. 316275010562 PS00190 Cytochrome c family heme-binding site signature. 316275010563 PS00190 Cytochrome c family heme-binding site signature. 316275010565 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 316275010566 HMMPfam hit to PF03892, Nitrate reductase cytochrome C subunit, score 1.1e-84 316275010567 PS00190 Cytochrome c family heme-binding site signature. 316275010568 PS00190 Cytochrome c family heme-binding site signature. 316275010569 Similar to Ralstonia eutropha Periplasmic nitrate reductase precursor NapA UniProt:P39185 (831 aa) fasta scores: E()=0, 68.592% id in 831 aa. CDS contains a frameshift after codon 398. The sequence has been checked and is believed to be correct 316275010570 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 1.8e-35 316275010571 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010572 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 3e-134 316275010573 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.1e-29 316275010574 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 dom, score 8.1e-23 316275010575 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 316275010576 NapD protein; Region: NapD; pfam03927 316275010577 HMMPfam hit to PF03927, NapD protein, score 1.9e-28 316275010578 ferredoxin-type protein NapF; Region: napF; TIGR00402 316275010579 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 316275010580 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316275010581 4Fe-4S binding domain; Region: Fer4; pfam00037 316275010582 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 1.9e-08 316275010583 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275010584 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00025 316275010585 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275010586 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275010587 PS00242 Integrins alpha chain signature. 316275010588 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 316275010589 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 316275010590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275010591 dimerization interface [polypeptide binding]; other site 316275010592 Histidine kinase; Region: HisKA_3; pfam07730 316275010593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275010594 ATP binding site [chemical binding]; other site 316275010595 Mg2+ binding site [ion binding]; other site 316275010596 G-X-G motif; other site 316275010598 HMMPfam hit to PF00672, HAMP domain, score 2.5e-14 316275010599 HMMPfam hit to PF07730, Histidine kinase, score 6.1e-17 316275010600 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.7e-19 316275010601 transcriptional regulator NarP; Provisional; Region: PRK10403 316275010602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275010603 active site 316275010604 phosphorylation site [posttranslational modification] 316275010605 intermolecular recognition site; other site 316275010606 dimerization interface [polypeptide binding]; other site 316275010607 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316275010608 DNA binding residues [nucleotide binding] 316275010609 dimerization interface [polypeptide binding]; other site 316275010610 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.7e-39 316275010611 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 9.1e-25 316275010612 PS00622 Bacterial regulatory proteins, luxR family signature. 316275010613 Predicted helix-turn-helix motif with score 1580.000, SD 4.57 at aa 161-182, sequence MRNKQVADKLFISEATVKVHMK 316275010614 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 316275010615 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275010616 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 316275010617 PAAR motif; Region: PAAR_motif; pfam05488 316275010618 HMMPfam hit to PF05488, PAAR motif, score 3.1e-06 316275010619 HMMPfam hit to PF05488, PAAR motif, score 2.2e-07 316275010620 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 316275010621 ArsC family; Region: ArsC; pfam03960 316275010622 putative catalytic residues [active] 316275010623 HMMPfam hit to PF03960, ArsC family, score 2.2e-26 316275010624 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 316275010625 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 316275010626 metal binding site [ion binding]; metal-binding site 316275010627 dimer interface [polypeptide binding]; other site 316275010628 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 2e-52 316275010629 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 3.3e-31 316275010630 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 316275010631 HMMPfam hit to PF02557, D-alanyl-D-alanine carboxypeptidase, score 3.2e-53 316275010632 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 316275010634 lipoprotein; Provisional; Region: PRK11679 316275010635 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 316275010636 HMMPfam hit to PF06804, NlpB/DapX lipoprotein, score 3.9e-169 316275010637 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275010638 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 316275010639 dihydrodipicolinate synthase; Region: dapA; TIGR00674 316275010640 dimer interface [polypeptide binding]; other site 316275010641 active site 316275010642 catalytic residue [active] 316275010643 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 4.2e-140 316275010644 PS00666 Dihydrodipicolinate synthetase signature 2. 316275010645 PS00583 pfkB family of carbohydrate kinases signature 1. 316275010646 PS00665 Dihydrodipicolinate synthetase signature 1. 316275010647 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 316275010648 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 316275010649 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 316275010650 HMMPfam hit to PF01842, ACT domain, score 0.00071 316275010651 HMMPfam hit to PF01842, ACT domain, score 0.23 316275010652 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 316275010653 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 316275010654 catalytic triad [active] 316275010655 HMMPfam hit to PF08534, Redoxin, score 8.4e-21 316275010656 HMMPfam hit to PF00578, AhpC/TSA family, score 1.1e-09 316275010657 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316275010658 Domain of unknown function DUF20; Region: UPF0118; pfam01594 316275010659 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 1.9e-86 316275010661 SirA-like protein; Region: SirA; pfam01206 316275010662 CPxP motif; other site 316275010663 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 316275010664 Peptidase family M48; Region: Peptidase_M48; cl12018 316275010665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275010666 binding surface 316275010667 TPR motif; other site 316275010668 HMMPfam hit to PF01435, Peptidase family M48, score 6.8e-32 316275010669 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010670 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 316275010671 ArsC family; Region: ArsC; pfam03960 316275010672 catalytic residues [active] 316275010673 HMMPfam hit to PF03960, ArsC family, score 1.1e-42 316275010674 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 316275010676 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 316275010677 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 316275010678 HMMPfam hit to PF00860, Permease family, score 1.6e-112 316275010680 PS01116 Xanthine/uracil permeases family signature. 316275010681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316275010682 active site 316275010683 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 9.7e-15 316275010684 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 316275010685 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 316275010686 dimerization interface [polypeptide binding]; other site 316275010687 putative ATP binding site [chemical binding]; other site 316275010688 HMMPfam hit to PF00586, AIR synthase related protein, N-terminal dom, score 5.3e-74 316275010689 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal dom, score 2.2e-53 316275010690 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 316275010691 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 316275010692 active site 316275010693 substrate binding site [chemical binding]; other site 316275010694 cosubstrate binding site; other site 316275010695 catalytic site [active] 316275010696 HMMPfam hit to PF00551, Formyl transferase, score 1.4e-70 316275010697 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 316275010698 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 316275010699 putative active site [active] 316275010700 putative dimer interface [polypeptide binding]; other site 316275010701 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 4.3e-36 316275010702 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 316275010703 dimer interface [polypeptide binding]; other site 316275010704 active site 316275010705 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275010706 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275010707 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275010708 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 316275010709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 316275010710 active site 316275010711 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 316275010713 HMMPfam hit to PF00441, Acyl-CoA dehydrogenase, C-terminal doma, score 9.1e-11 316275010714 TIGR03503 family protein; Region: TIGR03503 316275010716 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 316275010717 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 316275010718 active site 316275010719 catalytic site [active] 316275010720 substrate binding site [chemical binding]; other site 316275010721 HMMPfam hit to PF00929, Exonuclease, score 4.8e-42 316275010722 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 316275010723 RNA/DNA hybrid binding site [nucleotide binding]; other site 316275010724 active site 316275010725 HMMPfam hit to PF00075, RNase H, score 1.7e-61 316275010726 Methyltransferase domain; Region: Methyltransf_11; pfam08241 316275010727 HMMPfam hit to PF08241, Methyltransferase domain, score 0.0018 316275010728 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 316275010729 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 4.7e-35 316275010730 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 316275010731 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275010732 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275010733 catalytic residue [active] 316275010734 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275010735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275010736 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 316275010737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275010738 HMMPfam hit to PF06474, MLTD_N, score 6.9e-27 316275010739 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275010740 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.4e-25 316275010741 PS00922 Prokaryotic transglycosylases signature. 316275010742 HMMPfam hit to PF01476, LysM domain, score 9.3e-11 316275010743 HMMPfam hit to PF01476, LysM domain, score 1.9e-15 316275010744 HMMPfam hit to PF01476, LysM domain, score 6.7e-13 316275010745 Predicted helix-turn-helix motif with score 986.000, SD 2.55 at aa 472-493, sequence DNLSSIAQKFSVSVTDIMKWNS 316275010747 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275010748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275010749 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275010750 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275010751 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275010752 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275010753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275010754 hypothetical protein; Provisional; Region: PRK05421 316275010755 putative catalytic site [active] 316275010756 putative metal binding site [ion binding]; other site 316275010757 putative catalytic site [active] 316275010758 putative phosphate binding site [ion binding]; other site 316275010759 putative phosphate binding site [ion binding]; other site 316275010760 putative metal binding site [ion binding]; other site 316275010761 HMMPfam hit to PF03372, Endonuclease/Exonuclease/phosphatase fa, score 7.4e-15 316275010763 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 316275010764 Nitrogen regulatory protein P-II; Region: P-II; smart00938 316275010765 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 2.5e-72 316275010766 PS00638 P-II protein C-terminal region signature. 316275010767 PS00496 P-II protein urydylation site. 316275010768 Cytochrome c553 [Energy production and conversion]; Region: COG2863 316275010769 HMMPfam hit to PF00034, Cytochrome c, score 1.8e-13 316275010770 PS00190 Cytochrome c family heme-binding site signature. 316275010771 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 316275010772 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 316275010773 Ligand Binding Site [chemical binding]; other site 316275010774 TilS substrate binding domain; Region: TilS; pfam09179 316275010775 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 316275010776 HMMPfam hit to PF01171, PP-loop family, score 3.6e-80 316275010777 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 316275010778 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 316275010779 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 1.3e-93 316275010780 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 316275010781 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 316275010782 putative active site [active] 316275010783 putative PHP Thumb interface [polypeptide binding]; other site 316275010784 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 316275010785 generic binding surface II; other site 316275010786 generic binding surface I; other site 316275010787 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.8e-15 316275010788 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 1.2e-300 316275010789 HMMPfam hit to PF02811, PHP domain, score 8.5e-57 316275010790 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 316275010791 RNA/DNA hybrid binding site [nucleotide binding]; other site 316275010792 active site 316275010793 HMMPfam hit to PF01351, Ribonuclease HII, score 8.1e-83 316275010794 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 316275010795 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 316275010796 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 5.2e-154 316275010797 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 316275010798 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 316275010799 active site 316275010800 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 37 316275010801 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.36 316275010802 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 36 316275010803 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 15 316275010804 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.6 316275010805 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.016 316275010806 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.22 316275010807 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 316275010808 HMMPfam hit to PF07977, FabA-like domain, score 2.2e-70 316275010809 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 316275010810 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 316275010811 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 316275010812 trimer interface [polypeptide binding]; other site 316275010813 active site 316275010814 UDP-GlcNAc binding site [chemical binding]; other site 316275010815 lipid binding site [chemical binding]; lipid-binding site 316275010816 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.09 316275010817 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 53 316275010818 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.17 316275010819 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.036 316275010820 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.68 316275010821 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.071 316275010822 PS00101 Hexapeptide-repeat containing-transferases signature. 316275010823 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.041 316275010824 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.016 316275010825 HMMPfam hit to PF04613, UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 8.4e-43 316275010826 periplasmic chaperone; Provisional; Region: PRK10780 316275010827 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 316275010828 HMMPfam hit to PF03938, Outer membrane protein (OmpH-like), score 1.5e-53 316275010829 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 316275010830 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316275010831 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316275010832 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316275010833 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 316275010834 Surface antigen; Region: Bac_surface_Ag; pfam01103 316275010835 HMMPfam hit to PF01103, Surface antigen, score 7.7e-64 316275010836 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.2e-20 316275010837 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 5e-15 316275010838 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.2e-17 316275010839 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.3e-15 316275010840 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 6.3e-10 316275010841 zinc metallopeptidase RseP; Provisional; Region: PRK10779 316275010842 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 316275010843 active site 316275010844 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 316275010845 protein binding site [polypeptide binding]; other site 316275010846 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 316275010847 protein binding site [polypeptide binding]; other site 316275010848 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 316275010849 putative substrate binding region [chemical binding]; other site 316275010850 HMMPfam hit to PF02163, Peptidase family M50, score 3.5e-97 316275010852 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 316275010853 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 316275010854 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 316275010855 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 316275010856 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 316275010857 HMMPfam hit to PF08436, 1-deoxy-D-xylulose 5-phosphate reduct, score 4.7e-60 316275010858 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 1.8e-71 316275010859 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 316275010860 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 316275010861 HMMPfam hit to PF01148, Cytidylyltransferase family, score 2.5e-80 316275010862 PS01315 Phosphatidate cytidylyltransferase signature. 316275010864 PS00017 ATP/GTP-binding site motif A (P-loop). 316275010865 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 316275010866 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 316275010867 catalytic residue [active] 316275010868 putative FPP diphosphate binding site; other site 316275010869 putative FPP binding hydrophobic cleft; other site 316275010870 dimer interface [polypeptide binding]; other site 316275010871 putative IPP diphosphate binding site; other site 316275010872 HMMPfam hit to PF01255, undecaprenyl diphosphate syntha, score 6.9e-118 316275010873 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 316275010874 ribosome recycling factor; Reviewed; Region: frr; PRK00083 316275010875 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 316275010876 hinge region; other site 316275010877 HMMPfam hit to PF01765, Ribosome recycling factor, score 2.2e-89 316275010878 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 316275010879 putative nucleotide binding site [chemical binding]; other site 316275010880 uridine monophosphate binding site [chemical binding]; other site 316275010881 homohexameric interface [polypeptide binding]; other site 316275010882 HMMPfam hit to PF00696, Amino acid kinase family, score 6.6e-65 316275010883 elongation factor Ts; Provisional; Region: tsf; PRK09377 316275010884 UBA/TS-N domain; Region: UBA; pfam00627 316275010885 Elongation factor TS; Region: EF_TS; pfam00889 316275010886 Elongation factor TS; Region: EF_TS; pfam00889 316275010887 HMMPfam hit to PF00889, Elongation factor TS, score 2.8e-86 316275010888 PS01127 Elongation factor Ts signature 2. 316275010889 HMMPfam hit to PF00627, UBA/TS-N domain, score 5.2e-10 316275010890 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 316275010891 rRNA interaction site [nucleotide binding]; other site 316275010892 S8 interaction site; other site 316275010893 putative laminin-1 binding site; other site 316275010894 HMMPfam hit to PF00318, Ribosomal protein S2, score 1.6e-119 316275010895 PS00963 Ribosomal protein S2 signature 2. 316275010896 PS00962 Ribosomal protein S2 signature 1. 316275010897 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 316275010898 active site 316275010899 HMMPfam hit to PF00557, metallopeptidase family M24, score 1.4e-79 316275010900 PS00680 Methionine aminopeptidase subfamily 1 signature. 316275010901 PII uridylyl-transferase; Provisional; Region: PRK05007 316275010902 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316275010903 metal binding triad; other site 316275010904 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 316275010905 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275010906 Zn2+ binding site [ion binding]; other site 316275010907 Mg2+ binding site [ion binding]; other site 316275010908 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 316275010909 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 316275010910 HMMPfam hit to PF01909, Nucleotidyltransferase domain, score 4.3e-10 316275010911 HMMPfam hit to PF08335, GlnD PII-uridylyltransferase, score 4.5e-110 316275010912 HMMPfam hit to PF01966, HD domain, score 2.4e-19 316275010913 Predicted helix-turn-helix motif with score 1024.000, SD 2.67 at aa 602-623, sequence WKRSLIADLYNATQRALRRGLE 316275010914 HMMPfam hit to PF01842, ACT domain, score 8.5e-07 316275010915 HMMPfam hit to PF01842, ACT domain, score 1e-07 316275010916 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275010917 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275010918 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275010919 hypothetical protein; Provisional; Region: PRK13677 316275010920 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 316275010921 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 316275010922 Protein export membrane protein; Region: SecD_SecF; pfam02355 316275010923 HMMPfam hit to PF02355, Protein export membrane protein, score 2.5e-87 316275010925 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 0.00031 316275010926 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 316275010927 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 316275010928 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 316275010929 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 316275010930 HMMPfam hit to PF02355, Protein export membrane protein, score 2.9e-07 316275010932 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 1.6e-06 316275010933 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 316275010934 HMMPfam hit to PF02699, Preprotein translocase subunit, score 2.7e-39 316275010936 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 316275010937 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 316275010938 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 7.1e-161 316275010939 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 316275010940 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 316275010941 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 3.3e-123 316275010942 FOG: CBS domain [General function prediction only]; Region: COG0517 316275010943 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 316275010944 HMMPfam hit to PF00571, CBS domain pair, score 6e-31 316275010945 isocitrate lyase; Provisional; Region: PRK15063 316275010946 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 316275010947 tetramer interface [polypeptide binding]; other site 316275010948 active site 316275010949 Mg2+/Mn2+ binding site [ion binding]; other site 316275010950 HMMPfam hit to PF00463, Isocitrate lyase family, score 1.5e-253 316275010951 PS00161 Isocitrate lyase signature. 316275010952 malate synthase A; Region: malate_syn_A; TIGR01344 316275010953 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 316275010954 active site 316275010955 HMMPfam hit to PF01274, Malate synthase, score 2e-302 316275010956 Predicted helix-turn-helix motif with score 1125.000, SD 3.02 at aa 444-465, sequence YGLMEDAATAEISRTSIWQWIQ 316275010957 PS00510 Malate synthase signature. 316275010958 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 316275010959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275010960 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 316275010961 dimerization interface [polypeptide binding]; other site 316275010962 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.8e-36 316275010963 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.5e-17 316275010964 PS00044 Bacterial regulatory proteins, lysR family signature. 316275010965 Predicted helix-turn-helix motif with score 1793.000, SD 5.29 at aa 20-41, sequence RHFGEAAEKCFVSQSTLSKGIQ 316275010966 peroxidase; Provisional; Region: PRK15000 316275010967 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 316275010968 dimer interface [polypeptide binding]; other site 316275010969 decamer (pentamer of dimers) interface [polypeptide binding]; other site 316275010970 catalytic triad [active] 316275010971 peroxidatic and resolving cysteines [active] 316275010972 HMMPfam hit to PF08534, Redoxin, score 1.7e-09 316275010973 HMMPfam hit to PF00578, AhpC/TSA family, score 2.3e-82 316275010974 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 316275010975 HMMPfam hit to PF03932, CutC family, score 1.2e-105 316275010976 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 316275010977 HMMPfam hit to PF04076, Domain unknown function (DUF388), score 1.7e-45 316275010978 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275010979 HMMPfam hit to PF01389, OmpA-like transmembrane domain, score 0.00014 316275010980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275010981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275010982 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 316275010983 substrate binding pocket [chemical binding]; other site 316275010984 dimerization interface [polypeptide binding]; other site 316275010985 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.3e-16 316275010986 Predicted helix-turn-helix motif with score 1721.000, SD 5.05 at aa 24-45, sequence LNMRKASERLFVSQPAISQALQ 316275010987 PS00044 Bacterial regulatory proteins, lysR family signature. 316275010988 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.5e-05 316275010989 YadA-like C-terminal region; Region: YadA; pfam03895 316275010990 PS00697 ATP-dependent DNA ligase AMP-binding site. 316275010991 Homeodomain-like domain; Region: HTH_23; cl17451 316275010992 Winged helix-turn helix; Region: HTH_29; pfam13551 316275010993 Homeodomain-like domain; Region: HTH_32; pfam13565 316275010994 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275010995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275010996 transcriptional regulator PhoU; Provisional; Region: PRK11115 316275010997 PhoU domain; Region: PhoU; pfam01895 316275010998 PhoU domain; Region: PhoU; pfam01895 316275010999 HMMPfam hit to PF01895, PhoU family, score 2.3e-27 316275011000 HMMPfam hit to PF01895, PhoU family, score 2.2e-31 316275011001 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 316275011002 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 316275011003 Walker A/P-loop; other site 316275011004 ATP binding site [chemical binding]; other site 316275011005 Q-loop/lid; other site 316275011006 ABC transporter signature motif; other site 316275011007 Walker B; other site 316275011008 D-loop; other site 316275011009 H-loop/switch region; other site 316275011010 HMMPfam hit to PF00005, ABC transporter score 5.3e-63 316275011011 PS00211 ABC transporters family signature. 316275011012 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011013 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 316275011014 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 316275011015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011016 dimer interface [polypeptide binding]; other site 316275011017 conserved gate region; other site 316275011018 putative PBP binding loops; other site 316275011019 ABC-ATPase subunit interface; other site 316275011020 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.6e-16 316275011022 Predicted helix-turn-helix motif with score 1003.000, SD 2.60 at aa 124-145, sequence GTIIKASSGLELTRQQVESWVK 316275011023 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 316275011024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011025 dimer interface [polypeptide binding]; other site 316275011026 conserved gate region; other site 316275011027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011028 putative PBP binding loops; other site 316275011029 ABC-ATPase subunit interface; other site 316275011030 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 6.4e-05 316275011032 PBP superfamily domain; Region: PBP_like_2; cl17296 316275011033 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 316275011034 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 316275011035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316275011036 putative active site [active] 316275011037 heme pocket [chemical binding]; other site 316275011038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275011039 dimer interface [polypeptide binding]; other site 316275011040 phosphorylation site [posttranslational modification] 316275011041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275011042 ATP binding site [chemical binding]; other site 316275011043 Mg2+ binding site [ion binding]; other site 316275011044 G-X-G motif; other site 316275011045 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.4e-36 316275011046 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.5e-20 316275011047 HMMPfam hit to PF00989, PAS fold, score 5.7e-10 316275011049 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 316275011050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275011051 active site 316275011052 phosphorylation site [posttranslational modification] 316275011053 intermolecular recognition site; other site 316275011054 dimerization interface [polypeptide binding]; other site 316275011055 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275011056 DNA binding site [nucleotide binding] 316275011057 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.8e-21 316275011058 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.2e-38 316275011059 Putative exonuclease, RdgC; Region: RdgC; pfam04381 316275011060 HMMPfam hit to PF04381, exonuclease, RdgC, score 6.8e-188 316275011062 HMMPfam hit to PF00474, Sodium:solute symporter family, score 2.3e-22 316275011063 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275011064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275011065 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.7e-107, 53.320% id in 497 aa. CDS contains a frameshift after codon 287 316275011066 benzoate transport; Region: 2A0115; TIGR00895 316275011067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275011068 putative substrate translocation pore; other site 316275011070 HMMPfam hit to PF00083, Sugar (and other) transporter score 1e-06 316275011071 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-26 316275011072 SnoaL-like domain; Region: SnoaL_2; pfam12680 316275011073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 316275011074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275011075 DNA binding site [nucleotide binding] 316275011076 domain linker motif; other site 316275011077 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 316275011078 putative dimerization interface [polypeptide binding]; other site 316275011079 putative ligand binding site [chemical binding]; other site 316275011080 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 5.7e-05 316275011081 Predicted helix-turn-helix motif with score 2288.000, SD 6.98 at aa 8-29, sequence ITSKDVAKLAGVSQSTVSRVFI 316275011082 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.4e-09 316275011083 putative protease; Provisional; Region: PRK15452 316275011084 Peptidase family U32; Region: Peptidase_U32; pfam01136 316275011085 HMMPfam hit to PF01136, Peptidase family U32, score 1.8e-136 316275011086 PS01276 Peptidase family U32 signature. 316275011087 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316275011088 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 2.3e-05 316275011089 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275011090 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E3A9 (364 aa) fasta scores: E()=2.7e-112, 78.571% id in 364 aa. CDS is disrupted by the insertion of an IS element after codon 112 316275011091 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275011092 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275011093 HMMPfam hit to PF01609, Transposase DDE domain, score 5.2e-29 316275011094 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275011095 chaperone protein DnaJ; Provisional; Region: PRK10767 316275011096 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316275011097 HSP70 interaction site [polypeptide binding]; other site 316275011098 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 316275011099 substrate binding site [polypeptide binding]; other site 316275011100 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 316275011101 Zn binding sites [ion binding]; other site 316275011102 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 316275011103 dimer interface [polypeptide binding]; other site 316275011104 HMMPfam hit to PF01556, DnaJ C terminal region, score 6.1e-76 316275011105 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 1.2e-45 316275011106 PS00637 CXXCXGXG dnaJ domain signature. 316275011107 HMMPfam hit to PF00226, DnaJ domain, score 1.5e-36 316275011108 PS00636 Nt-dnaJ domain signature. 316275011109 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 316275011110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 316275011111 nucleotide binding site [chemical binding]; other site 316275011112 HMMPfam hit to PF00012, Hsp70 protein, score 0 316275011113 PS01036 Heat shock hsp70 proteins family signature 3. 316275011114 PS00329 Heat shock hsp70 proteins family signature 2. 316275011115 PS00297 Heat shock hsp70 proteins family signature 1. 316275011117 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 316275011118 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 316275011119 dimer interface [polypeptide binding]; other site 316275011120 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 316275011121 HMMPfam hit to PF01025, GrpE, score 4e-63 316275011122 PS01071 grpE protein signature. 316275011123 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 316275011124 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 316275011125 HMMPfam hit to PF01513, ATP-NAD kinase, score 2.7e-87 316275011126 recombination and repair protein; Provisional; Region: PRK10869 316275011127 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 316275011128 Walker A/P-loop; other site 316275011129 ATP binding site [chemical binding]; other site 316275011130 Q-loop/lid; other site 316275011131 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 316275011132 ABC transporter signature motif; other site 316275011133 Walker B; other site 316275011134 D-loop; other site 316275011135 H-loop/switch region; other site 316275011136 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 1.7e-10 316275011137 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011138 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 316275011139 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 316275011140 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275011141 HMMPfam hit to PF04355, SmpA / OmlA family, score 1.7e-34 316275011142 hypothetical protein; Validated; Region: PRK01777 316275011143 HMMPfam hit to PF03658, Uncharacterised protein family (UPF0125), score 8.2e-48 316275011144 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 316275011145 putative coenzyme Q binding site [chemical binding]; other site 316275011146 HMMPfam hit to PF03364, Streptomyces cyclase/dehydrase, score 4.6e-40 316275011147 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 316275011148 SmpB-tmRNA interface; other site 316275011149 HMMPfam hit to PF01668, SmpB protein, score 1.8e-39 316275011150 PS01317 Protein smpB signature. 316275011151 integrase; Provisional; Region: PRK09692 316275011152 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 316275011153 active site 316275011154 Int/Topo IB signature motif; other site 316275011155 HMMPfam hit to PF00589, Phage integrase family, score 9.7e-25 316275011156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275011157 AAA domain; Region: AAA_21; pfam13304 316275011158 Walker A/P-loop; other site 316275011159 ATP binding site [chemical binding]; other site 316275011160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 316275011161 Q-loop/lid; other site 316275011162 ABC transporter signature motif; other site 316275011163 Walker B; other site 316275011164 D-loop; other site 316275011165 H-loop/switch region; other site 316275011166 HMMPfam hit to PF00005, ABC transporter score 3e-08 316275011167 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011168 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011169 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275011170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275011171 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275011172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275011173 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275011174 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275011175 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275011176 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=3e-117, 55.781% id in 493 aa. CDS contains a frameshift after codon 42 316275011177 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275011178 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275011179 pyridoxamine kinase; Validated; Region: PRK05756 316275011180 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 316275011181 dimer interface [polypeptide binding]; other site 316275011182 pyridoxal binding site [chemical binding]; other site 316275011183 ATP binding site [chemical binding]; other site 316275011184 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase, score 2.5e-05 316275011185 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275011186 lysine decarboxylase CadA; Provisional; Region: PRK15400 316275011187 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 316275011188 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 316275011189 homodimer interface [polypeptide binding]; other site 316275011190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275011191 catalytic residue [active] 316275011192 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 316275011193 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase, C-terminal doma, score 4e-84 316275011194 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase, major domain, score 1.7e-271 316275011195 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 316275011196 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase, N-terminal doma, score 5.1e-46 316275011197 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 316275011198 HMMPfam hit to PF00324, Amino acid permease, score 3.9e-06 316275011200 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 316275011201 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 316275011203 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 1.8e-203 316275011204 PS00873 Sodium:alanine symporter family signature. 316275011205 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 316275011206 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275011207 DNA binding site [nucleotide binding] 316275011208 Predicted integral membrane protein [Function unknown]; Region: COG5616 316275011209 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 2.1e-19 316275011210 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316275011211 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316275011212 active site 316275011213 metal binding site [ion binding]; metal-binding site 316275011214 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 0.00036 316275011215 Predicted transporter component [General function prediction only]; Region: COG2391 316275011216 Sulphur transport; Region: Sulf_transp; pfam04143 316275011217 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 1.2e-18 316275011219 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 316275011220 Predicted transporter component [General function prediction only]; Region: COG2391 316275011221 Sulphur transport; Region: Sulf_transp; pfam04143 316275011222 HMMPfam hit to PF04143, YeeE/YedE family (DUF395), score 3.1e-19 316275011224 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 316275011225 EamA-like transporter family; Region: EamA; pfam00892 316275011227 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 8.4e-24 316275011228 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.6e-12 316275011229 homoserine O-succinyltransferase; Provisional; Region: PRK05368 316275011230 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 316275011231 proposed active site lysine [active] 316275011232 conserved cys residue [active] 316275011233 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 4.6e-206 316275011234 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 316275011235 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 316275011236 HMMPfam hit to PF03605, Anaerobic c4-dicarboxylate membrane transpo, score 1.8e-236 316275011238 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 316275011239 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 316275011240 Nucleoside recognition; Region: Gate; pfam07670 316275011241 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 316275011243 HMMPfam hit to PF07662, Na+ dependent nucleoside transporter C, score 5e-99 316275011244 HMMPfam hit to PF07670, Nucleoside recognition, score 2.1e-16 316275011245 HMMPfam hit to PF01773, Na+ dependent nucleoside transporter N, score 9.9e-33 316275011246 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063 316275011248 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 316275011249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011250 dimer interface [polypeptide binding]; other site 316275011251 conserved gate region; other site 316275011252 putative PBP binding loops; other site 316275011253 ABC-ATPase subunit interface; other site 316275011255 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 316275011256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275011257 Walker A/P-loop; other site 316275011258 ATP binding site [chemical binding]; other site 316275011259 Q-loop/lid; other site 316275011260 ABC transporter signature motif; other site 316275011261 Walker B; other site 316275011262 D-loop; other site 316275011263 H-loop/switch region; other site 316275011264 HMMPfam hit to PF00005, ABC transporter score 3.5e-47 316275011265 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011266 PS00211 ABC transporters family signature. 316275011267 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 316275011269 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275011270 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 4.2e-17 316275011271 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 316275011272 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316275011273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316275011274 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316275011275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316275011276 DNA binding residues [nucleotide binding] 316275011277 HMMPfam hit to PF04545, Sigma-70, region, score 1.6e-19 316275011278 PS00716 Sigma-70 factors family signature 2. 316275011279 Predicted helix-turn-helix motif with score 1365.000, SD 3.84 at aa 274-295, sequence STLEQVGREIGLTRERVRQIQV 316275011280 HMMPfam hit to PF04539, Sigma-70 region, score 1.2e-27 316275011281 Predicted helix-turn-helix motif with score 1365.000, SD 3.84 at aa 181-202, sequence PTPEEIAEKLDKPVSDVSRMLR 316275011282 HMMPfam hit to PF04542, Sigma-70 region, score 1.1e-26 316275011283 PS00715 Sigma-70 factors family signature 1. 316275011284 HMMPfam hit to PF00140, Sigma-70 factor, region, score 6.9e-13 316275011285 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 316275011286 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275011287 Peptidase family M23; Region: Peptidase_M23; pfam01551 316275011288 HMMPfam hit to PF01551, Peptidase family M23, score 3.3e-43 316275011289 HMMPfam hit to PF01476, LysM domain, score 1.2e-11 316275011291 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275011292 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 316275011293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275011294 S-adenosylmethionine binding site [chemical binding]; other site 316275011295 HMMPfam hit to PF01135, Protein-L-isoaspartate(D-aspartate) O-methyl, score 3.4e-86 316275011296 PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 316275011297 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 316275011298 HMMPfam hit to PF01975, Survival protein SurE, score 7.9e-85 316275011299 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011300 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 316275011301 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 316275011302 Permutation of conserved domain; other site 316275011303 active site 316275011304 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 316275011305 HMMPfam hit to PF01142, tRNA pseudouridine synthase D (TruD), score 7.8e-120 316275011306 PS01268 Uncharacterized protein family UPF0024 signature. 316275011307 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 316275011308 homotrimer interaction site [polypeptide binding]; other site 316275011309 zinc binding site [ion binding]; other site 316275011310 CDP-binding sites; other site 316275011311 HMMPfam hit to PF02542, YgbB family, score 7.2e-89 316275011312 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 316275011313 substrate binding site; other site 316275011314 dimer interface; other site 316275011315 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 5.9e-99 316275011316 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 316275011317 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 316275011318 HMMPfam hit to PF04977, Septum formation initiator, score 1e-26 316275011320 enolase; Provisional; Region: eno; PRK00077 316275011321 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 316275011322 dimer interface [polypeptide binding]; other site 316275011323 metal binding site [ion binding]; metal-binding site 316275011324 substrate binding pocket [chemical binding]; other site 316275011325 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 1.9e-181 316275011326 PS00164 Enolase signature. 316275011327 HMMPfam hit to PF03952, Enolase, N-terminal domain, score 8.2e-70 316275011328 CTP synthetase; Validated; Region: pyrG; PRK05380 316275011329 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 316275011330 Catalytic site [active] 316275011331 active site 316275011332 UTP binding site [chemical binding]; other site 316275011333 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 316275011334 active site 316275011335 putative oxyanion hole; other site 316275011336 catalytic triad [active] 316275011337 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.6e-74 316275011338 PS00442 Glutamine amidotransferases class-I active site. 316275011339 HMMPfam hit to PF06418, CTP synthase N-terminus, score 5.1e-208 316275011341 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 316275011342 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 316275011343 homodimer interface [polypeptide binding]; other site 316275011344 metal binding site [ion binding]; metal-binding site 316275011345 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 316275011346 homodimer interface [polypeptide binding]; other site 316275011347 active site 316275011348 putative chemical substrate binding site [chemical binding]; other site 316275011349 metal binding site [ion binding]; metal-binding site 316275011350 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 9.9e-06 316275011351 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 2.7e-41 316275011352 flagellin; Reviewed; Region: PRK08869 316275011353 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 316275011354 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 316275011355 HMMPfam hit to PF00700, Bacterial flagellin C-terminus, score 2.7e-30 316275011356 HMMPfam hit to PF07196, Flagellin hook IN motif, score 3.1e-08 316275011357 HMMPfam hit to PF00669, Bacterial flagellin N-terminus, score 1.8e-63 316275011358 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 316275011359 HD domain; Region: HD_4; pfam13328 316275011360 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 316275011361 synthetase active site [active] 316275011362 NTP binding site [chemical binding]; other site 316275011363 metal binding site [ion binding]; metal-binding site 316275011364 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 316275011365 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 316275011366 HMMPfam hit to PF01842, ACT domain, score 0.00073 316275011367 HMMPfam hit to PF02824, TGS domain, score 3.8e-27 316275011368 HMMPfam hit to PF04607, Region found in RelA / SpoT proteins, score 4.1e-46 316275011369 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 316275011370 TRAM domain; Region: TRAM; pfam01938 316275011371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275011372 S-adenosylmethionine binding site [chemical binding]; other site 316275011373 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 3.8e-10 316275011374 PS01231 RNA methyltransferase trmA family signature 2. 316275011375 PS01230 RNA methyltransferase trmA family signature 1. 316275011376 HMMPfam hit to PF01938, TRAM domain, score 3e-05 316275011377 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 316275011378 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 316275011379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275011380 dimerization interface [polypeptide binding]; other site 316275011381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275011382 dimer interface [polypeptide binding]; other site 316275011383 phosphorylation site [posttranslational modification] 316275011384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275011385 ATP binding site [chemical binding]; other site 316275011386 Mg2+ binding site [ion binding]; other site 316275011387 G-X-G motif; other site 316275011388 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 316275011389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275011390 active site 316275011391 phosphorylation site [posttranslational modification] 316275011392 intermolecular recognition site; other site 316275011393 dimerization interface [polypeptide binding]; other site 316275011394 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316275011395 putative binding surface; other site 316275011396 active site 316275011398 HMMPfam hit to PF00672, HAMP domain, score 1.6e-12 316275011399 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.3e-27 316275011400 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.1e-25 316275011401 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.8e-39 316275011402 HMMPfam hit to PF00072, Response regulator receiver domain, score 1e-34 316275011403 HMMPfam hit to PF01627, Hpt domain, score 2.2e-09 316275011404 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 316275011405 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 2.5e-19 316275011406 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 316275011407 active site 316275011408 hydrophilic channel; other site 316275011409 dimerization interface [polypeptide binding]; other site 316275011410 catalytic residues [active] 316275011411 active site lid [active] 316275011412 HMMPfam hit to PF03740, Pyridoxal phosphate biosynthesis protein Pdx, score 2e-151 316275011413 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 316275011414 Recombination protein O N terminal; Region: RecO_N; pfam11967 316275011415 Recombination protein O C terminal; Region: RecO_C; pfam02565 316275011416 HMMPfam hit to PF02565, Recombination protein O, score 2e-75 316275011417 GTPase Era; Reviewed; Region: era; PRK00089 316275011418 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 316275011419 G1 box; other site 316275011420 GTP/Mg2+ binding site [chemical binding]; other site 316275011421 Switch I region; other site 316275011422 G2 box; other site 316275011423 Switch II region; other site 316275011424 G3 box; other site 316275011425 G4 box; other site 316275011426 G5 box; other site 316275011427 KH domain; Region: KH_2; pfam07650 316275011428 HMMPfam hit to PF07650, KH domain, score 3.8e-24 316275011429 HMMPfam hit to PF01926, GTPase of unknown function, score 5.7e-39 316275011430 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011431 ribonuclease III; Reviewed; Region: rnc; PRK00102 316275011432 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 316275011433 dimerization interface [polypeptide binding]; other site 316275011434 active site 316275011435 metal binding site [ion binding]; metal-binding site 316275011436 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 316275011437 dsRNA binding site [nucleotide binding]; other site 316275011438 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 1.3e-14 316275011439 HMMPfam hit to PF00636, RNase3 domain, score 1.4e-47 316275011440 PS00517 Ribonuclease III family signature. 316275011441 signal peptidase I; Provisional; Region: PRK10861 316275011442 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316275011443 Catalytic site [active] 316275011444 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 316275011445 PS00761 Signal peptidases I signature 3. 316275011446 HMMPfam hit to PF00717, Peptidase S24-like, score 4.2e-26 316275011447 PS00760 Signal peptidases I lysine active site. 316275011448 PS00501 Signal peptidases I serine active site. 316275011450 GTP-binding protein LepA; Provisional; Region: PRK05433 316275011451 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 316275011452 G1 box; other site 316275011453 putative GEF interaction site [polypeptide binding]; other site 316275011454 GTP/Mg2+ binding site [chemical binding]; other site 316275011455 Switch I region; other site 316275011456 G2 box; other site 316275011457 G3 box; other site 316275011458 Switch II region; other site 316275011459 G4 box; other site 316275011460 G5 box; other site 316275011461 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 316275011462 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 316275011463 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 316275011464 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 2.3e-76 316275011465 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 9.8e-35 316275011466 HMMPfam hit to PF03144, Elongation factor Tu domain, score 4.5e-05 316275011467 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 5.1e-75 316275011468 PS00301 GTP-binding elongation factors signature. 316275011469 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011470 Positive regulator of sigma E activity [Signal transduction mechanisms]; Region: RseC; COG3086 316275011471 HMMPfam hit to PF04246, Positive regulator of sigma(E), RseC/MucC, score 2.7e-42 316275011473 anti-sigma E factor; Provisional; Region: rseB; PRK09455 316275011474 MucB/RseB family; Region: MucB_RseB; pfam03888 316275011475 HMMPfam hit to PF03888, MucB/RseB family, score 5.1e-138 316275011476 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 316275011477 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 316275011478 HMMPfam hit to PF03873, Anti sigma-E protein RseA, C-terminal domain, score 8.7e-12 316275011479 HMMPfam hit to PF03872, Anti sigma-E protein RseA, N-terminal domain, score 1.2e-28 316275011480 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 316275011481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316275011482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316275011483 DNA binding residues [nucleotide binding] 316275011484 HMMPfam hit to PF04545, Sigma-70, region, score 2.5e-14 316275011485 HMMPfam hit to PF08281, Sigma-70, region, score 2.3e-17 316275011486 Predicted helix-turn-helix motif with score 1066.000, SD 2.82 at aa 155-176, sequence LSYEDIAAIMECPVGTVRSRIF 316275011487 HMMPfam hit to PF04542, Sigma-70 region, score 2.6e-21 316275011488 PS01063 Sigma-70 factors ECF subfamily signature. 316275011489 L-aspartate oxidase; Provisional; Region: PRK09077 316275011490 L-aspartate oxidase; Provisional; Region: PRK06175 316275011491 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316275011492 HMMPfam hit to PF00890, FAD binding domain, score 2.1e-135 316275011493 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidore, score 0.0021 316275011494 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 4.5e-06 316275011496 Uncharacterized conserved protein [Function unknown]; Region: COG2938 316275011497 HMMPfam hit to PF03937, TPR repeat region, score 3.3e-33 316275011498 putative global regulator; Reviewed; Region: PRK09559 316275011499 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 316275011500 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 316275011501 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 1.8e-06 316275011502 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 316275011503 HMMPfam hit to PF06526, Protein of unknown function (DUF1107), score 2.8e-25 316275011504 2-octaprenyl-6-methoxyphenol hydroxylase; Validated; Region: PRK08850 316275011505 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 316275011506 HMMPfam hit to PF01494, FAD binding domain, score 1e-09 316275011507 PS01304 ubiH/COQ6 monooxygenase family signature. 316275011508 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 316275011509 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 316275011510 HMMPfam hit to PF01494, FAD binding domain, score 5e-06 316275011511 PS01304 ubiH/COQ6 monooxygenase family signature. 316275011513 hypothetical protein; Reviewed; Region: PRK01736 316275011514 HMMPfam hit to PF03695, Uncharacterised protein family (UPF0149), score 2.5e-59 316275011515 Cell division protein ZapA; Region: ZapA; cl01146 316275011516 HMMPfam hit to PF05164, Cell division protein ZapA, score 6.7e-29 316275011517 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 316275011518 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 316275011519 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 1.2e-53 316275011520 PS00591 Glycosyl hydrolases family 10 active site. 316275011521 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 316275011522 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316275011523 active site 316275011524 dimer interface [polypeptide binding]; other site 316275011525 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase A (phosph, score 4e-93 316275011526 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275011527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275011528 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275011529 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 316275011530 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 316275011531 ligand binding site [chemical binding]; other site 316275011532 NAD binding site [chemical binding]; other site 316275011533 tetramer interface [polypeptide binding]; other site 316275011534 catalytic site [active] 316275011535 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 316275011536 L-serine binding site [chemical binding]; other site 316275011537 ACT domain interface; other site 316275011538 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrog, score 4.2e-39 316275011539 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 2.9e-67 316275011540 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 316275011541 PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 316275011542 HMMPfam hit to PF01842, ACT domain, score 6.1e-09 316275011543 Uncharacterized conserved protein [Function unknown]; Region: COG2968 316275011544 oxidative stress defense protein; Provisional; Region: PRK11087 316275011545 HMMPfam hit to PF04402, Protein of unknown function (DUF541), score 7.6e-58 316275011546 mechanosensitive channel MscS; Provisional; Region: PRK10334 316275011547 Conserved TM helix; Region: TM_helix; pfam05552 316275011548 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316275011549 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 5.6e-78 316275011550 PS01246 Uncharacterized protein family UPF0003 signature. 316275011552 HMMPfam hit to PF05552, Conserved TM helix, score 9.5e-12 316275011553 hypothetical protein; Validated; Region: PRK02101 316275011554 HMMPfam hit to PF03883, Protein of unknown function (DUF328), score 6e-163 316275011555 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 316275011556 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 316275011557 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 5.5e-221 316275011559 PS00873 Sodium:alanine symporter family signature. 316275011560 Protein of unknown function (DUF3545); Region: DUF3545; pfam12065 316275011561 Hemerythrin-like domain; Region: Hr-like; cd12108 316275011562 Fe binding site [ion binding]; other site 316275011563 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 0.43 316275011564 HMMPfam hit to PF01814, Hemerythrin HHE cation binding domain, score 2.2e-06 316275011565 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 316275011566 ligand binding site [chemical binding]; other site 316275011567 active site 316275011568 UGI interface [polypeptide binding]; other site 316275011569 catalytic site [active] 316275011570 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 8.1e-77 316275011571 endonuclease IV; Provisional; Region: PRK01060 316275011572 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 316275011573 AP (apurinic/apyrimidinic) site pocket; other site 316275011574 DNA interaction; other site 316275011575 Metal-binding active site; metal-binding site 316275011576 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 1.1e-58 316275011577 PS00731 AP endonucleases family 2 signature 3. 316275011578 PS00730 AP endonucleases family 2 signature 2. 316275011579 PS00729 AP endonucleases family 2 signature 1. 316275011580 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 316275011581 HMMPfam hit to PF01228, Glycine radical, score 2.8e-36 316275011582 PS00850 Glycine radical signature. 316275011583 threonine synthase; Validated; Region: PRK09225 316275011584 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 316275011585 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275011586 catalytic residue [active] 316275011587 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 2.1e-33 316275011588 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 316275011589 homoserine kinase; Provisional; Region: PRK01212 316275011590 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 316275011591 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 316275011592 HMMPfam hit to PF08544, GHMP kinases C terminal, score 2.3e-06 316275011593 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 1.5e-20 316275011594 PS00627 GHMP kinases ATP-binding protein. 316275011595 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 316275011596 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 316275011597 putative catalytic residues [active] 316275011598 putative nucleotide binding site [chemical binding]; other site 316275011599 putative aspartate binding site [chemical binding]; other site 316275011600 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 316275011601 dimer interface [polypeptide binding]; other site 316275011602 putative threonine allosteric regulatory site; other site 316275011603 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 316275011604 putative threonine allosteric regulatory site; other site 316275011605 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 316275011606 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 316275011607 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 2.9e-91 316275011608 PS01042 Homoserine dehydrogenase signature. 316275011609 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 3.5e-31 316275011610 HMMPfam hit to PF01842, ACT domain, score 0.0012 316275011611 HMMPfam hit to PF01842, ACT domain, score 2.6e-09 316275011612 HMMPfam hit to PF00696, Amino acid kinase family, score 1e-47 316275011613 PS00324 Aspartokinase signature. 316275011614 ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487 316275011615 HMMPfam hit to PF03737, Demethylmenaquinone methyltransferase, score 2.8e-67 316275011616 two-component response regulator; Provisional; Region: PRK11173 316275011617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275011618 active site 316275011619 phosphorylation site [posttranslational modification] 316275011620 intermolecular recognition site; other site 316275011621 dimerization interface [polypeptide binding]; other site 316275011622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275011623 DNA binding site [nucleotide binding] 316275011624 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.7e-36 316275011625 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.4e-17 316275011626 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275011627 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 316275011628 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316275011629 putative active site [active] 316275011630 heme pocket [chemical binding]; other site 316275011631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275011632 dimer interface [polypeptide binding]; other site 316275011633 phosphorylation site [posttranslational modification] 316275011634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275011635 ATP binding site [chemical binding]; other site 316275011636 Mg2+ binding site [ion binding]; other site 316275011637 G-X-G motif; other site 316275011638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275011639 active site 316275011640 phosphorylation site [posttranslational modification] 316275011641 intermolecular recognition site; other site 316275011642 dimerization interface [polypeptide binding]; other site 316275011643 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 316275011644 putative binding surface; other site 316275011645 active site 316275011646 HMMPfam hit to PF01627, Hpt domain, score 1.6e-10 316275011647 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.1e-18 316275011648 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.9e-31 316275011649 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.4e-18 316275011650 HMMPfam hit to PF08448, PAS fold, score 3.8e-13 316275011651 HMMPfam hit to PF00989, PAS fold, score 6.9e-16 316275011653 Similar to Vibrio fischeri Fe-S oxidoreductase UniProt:Q5E2X8 (313 aa) fasta scores: E()=1.4e-111, 87.540% id in 313 aa. CDS contains a frameshift after codon 160. The sequence has been checked and is believed to be correct 316275011654 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.4e-10 316275011655 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 316275011656 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 316275011657 active site 316275011658 dimer interface [polypeptide binding]; other site 316275011659 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 316275011660 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 316275011661 active site 316275011662 FMN binding site [chemical binding]; other site 316275011663 substrate binding site [chemical binding]; other site 316275011664 3Fe-4S cluster binding site [ion binding]; other site 316275011665 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 316275011666 domain interface; other site 316275011667 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 4.7e-227 316275011668 HMMPfam hit to PF04898, Glutamate synthase central domain, score 1.3e-190 316275011669 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 744-765, sequence YHGAQIFEALGISKSVVDKYFT 316275011670 HMMPfam hit to PF01645, Conserved region in glutamate synthas, score 3.4e-221 316275011671 HMMPfam hit to PF01493, GXGXG motif, score 1.5e-90 316275011672 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 316275011673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316275011674 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 2.4e-21 316275011675 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 316275011676 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275011677 HMMPfam hit to PF07386, Protein of unknown function (DUF1499), score 1.1e-50 316275011678 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 316275011679 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 316275011680 HMMPfam hit to PF01048, Phosphorylase family, score 4.7e-86 316275011681 adenosylcobinamide-phosphate synthase; Provisional; Region: PRK08878 316275011683 HMMPfam hit to PF03186, CobD/Cbib protein, score 1.1e-05 316275011684 hypothetical protein; Provisional; Region: PRK10578 316275011685 UPF0126 domain; Region: UPF0126; pfam03458 316275011686 UPF0126 domain; Region: UPF0126; pfam03458 316275011687 HMMPfam hit to PF03458, UPF0126 domain, score 2.2e-33 316275011689 HMMPfam hit to PF03458, UPF0126 domain, score 2.1e-35 316275011690 putative peptidase; Provisional; Region: PRK11649 316275011691 Peptidase family M23; Region: Peptidase_M23; pfam01551 316275011693 HMMPfam hit to PF01551, Peptidase family M23, score 4.4e-42 316275011694 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 316275011695 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family, score 2.4e-94 316275011697 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275011698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275011699 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275011701 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 316275011702 PS01152 Hypothetical hesB/yadR/yfhF family signature. 316275011703 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 2.8e-39 316275011704 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 316275011705 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316275011706 inhibitor-cofactor binding pocket; inhibition site 316275011707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275011708 catalytic residue [active] 316275011709 HMMPfam hit to PF00202, Aminotransferase class-III, score 1.3e-78 316275011710 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 316275011711 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 316275011712 Domain of unknown function DUF20; Region: UPF0118; pfam01594 316275011713 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 3.5e-47 316275011715 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 316275011716 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 316275011717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275011718 S-adenosylmethionine binding site [chemical binding]; other site 316275011719 HMMPfam hit to PF08468, Methyltransferase small domain N-terminal, score 8.1e-92 316275011720 HMMPfam hit to PF05175, Methyltransferase small domain, score 6.3e-81 316275011721 PS00092 N-6 Adenine-specific DNA methylases signature. 316275011722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275011723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275011724 dimerization interface [polypeptide binding]; other site 316275011725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275011726 dimer interface [polypeptide binding]; other site 316275011727 phosphorylation site [posttranslational modification] 316275011728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275011729 ATP binding site [chemical binding]; other site 316275011730 Mg2+ binding site [ion binding]; other site 316275011731 G-X-G motif; other site 316275011732 Response regulator receiver domain; Region: Response_reg; pfam00072 316275011733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275011734 active site 316275011735 phosphorylation site [posttranslational modification] 316275011736 intermolecular recognition site; other site 316275011737 dimerization interface [polypeptide binding]; other site 316275011739 HMMPfam hit to PF00672, HAMP domain, score 9.4e-19 316275011740 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.6e-20 316275011741 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 6.8e-41 316275011742 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.1e-43 316275011743 PS00217 Sugar transport proteins signature 2. 316275011744 Similar to Bacillus subtilis Oligopeptide-binding protein AppA precursor UniProt:P42061 (543 aa) fasta scores: E()=1.5e-12, 25.624% id in 441 aa. CDS contains a frameshift and a deletion of 8 amino acid residues after codon 468. The sequence has been checked and is believed to be correct 316275011745 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1e-69 316275011746 PS01040 Bacterial extracellular solute-binding proteins, family 5 signature. 316275011747 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 316275011748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011749 dimer interface [polypeptide binding]; other site 316275011750 conserved gate region; other site 316275011751 putative PBP binding loops; other site 316275011752 ABC-ATPase subunit interface; other site 316275011754 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 8.5e-56 316275011755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 316275011756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011757 dimer interface [polypeptide binding]; other site 316275011758 conserved gate region; other site 316275011759 putative PBP binding loops; other site 316275011760 ABC-ATPase subunit interface; other site 316275011762 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-23 316275011763 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 316275011764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316275011765 Walker A/P-loop; other site 316275011766 ATP binding site [chemical binding]; other site 316275011767 Q-loop/lid; other site 316275011768 ABC transporter signature motif; other site 316275011769 Walker B; other site 316275011770 D-loop; other site 316275011771 H-loop/switch region; other site 316275011772 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 316275011773 HMMPfam hit to PF00005, ABC transporter score 6.9e-49 316275011774 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011775 PS00211 ABC transporters family signature. 316275011776 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter C-termi, score 1.4e-20 316275011777 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 316275011778 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316275011779 Walker A/P-loop; other site 316275011780 ATP binding site [chemical binding]; other site 316275011781 Q-loop/lid; other site 316275011782 ABC transporter signature motif; other site 316275011783 Walker B; other site 316275011784 D-loop; other site 316275011785 H-loop/switch region; other site 316275011786 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 316275011787 HMMPfam hit to PF00005, ABC transporter score 1.9e-44 316275011788 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011789 PS00211 ABC transporters family signature. 316275011790 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter C-termi, score 1.3e-20 316275011791 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 316275011792 HMMPfam hit to PF00759, Glycosyl hydrolase family, score 0.0026 316275011793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316275011794 nucleotide binding site [chemical binding]; other site 316275011795 HMMPfam hit to PF01869, BadF/BadG/BcrA/BcrD ATPase family, score 6.2e-75 316275011796 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 316275011797 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 316275011798 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 316275011799 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 316275011800 active site 316275011801 HMMPfam hit to PF02838, Glycosyl hydrolase family 20, domain, score 0.00073 316275011802 HMMPfam hit to PF00728, Glycosyl hydrolase family 20, catalyt, score 2.1e-155 316275011803 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 316275011804 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 316275011805 catalytic domain interface [polypeptide binding]; other site 316275011806 putative homodimer interface [polypeptide binding]; other site 316275011807 HMMPfam hit to PF06204, carbohydrate binding domain, score 6.7e-30 316275011808 HMMPfam hit to PF06165, Glycosyltransferase family, score 2.6e-54 316275011809 HMMPfam hit to PF06205, Glycosyltransferase 36 associated fam, score 2.3e-27 316275011810 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 316275011811 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 316275011812 active site 316275011813 substrate binding site [chemical binding]; other site 316275011814 metal binding site [ion binding]; metal-binding site 316275011815 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase, al, score 2.7e-46 316275011816 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase, al, score 2.7e-13 316275011817 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase, al, score 1e-11 316275011818 PS00012 Phosphopantetheine attachment site. 316275011819 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase, C-, score 0.00044 316275011820 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316275011821 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 316275011822 Walker A/P-loop; other site 316275011823 ATP binding site [chemical binding]; other site 316275011824 Q-loop/lid; other site 316275011825 ABC transporter signature motif; other site 316275011826 Walker B; other site 316275011827 D-loop; other site 316275011828 H-loop/switch region; other site 316275011829 TOBE domain; Region: TOBE_2; pfam08402 316275011830 HMMPfam hit to PF08402, TOBE domain, score 7.2e-06 316275011831 HMMPfam hit to PF00005, ABC transporter score 2.4e-67 316275011832 PS00211 ABC transporters family signature. 316275011833 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011834 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 316275011835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011836 dimer interface [polypeptide binding]; other site 316275011837 conserved gate region; other site 316275011838 putative PBP binding loops; other site 316275011839 ABC-ATPase subunit interface; other site 316275011840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275011841 dimer interface [polypeptide binding]; other site 316275011842 conserved gate region; other site 316275011843 putative PBP binding loops; other site 316275011844 ABC-ATPase subunit interface; other site 316275011845 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0037 316275011847 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.2e-13 316275011848 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 316275011849 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 316275011850 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 3e-10 316275011851 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 316275011852 HMMPfam hit to PF00909, Ammonium Transporter Family, score 1.6e-118 316275011854 PS01219 Ammonium transporters signature. 316275011855 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 316275011856 Nitrogen regulatory protein P-II; Region: P-II; smart00938 316275011857 HMMPfam hit to PF00543, Nitrogen regulatory protein P-II, score 2.1e-70 316275011858 PS00638 P-II protein C-terminal region signature. 316275011859 hypothetical protein; Provisional; Region: PRK05248 316275011860 HMMPfam hit to PF06062, Uncharacterised protein family (UPF0231), score 6.4e-43 316275011861 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 316275011862 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 316275011863 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 316275011864 HMMPfam hit to PF05651, sugar diacid recognition, score 6.5e-109 316275011865 fructuronate transporter; Provisional; Region: PRK10034; cl15264 316275011866 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 316275011868 HMMPfam hit to PF02447, GntP family permease, score 3.7e-07 316275011869 HMMPfam hit to PF03600, Citrate transporter score 5.8e-08 316275011870 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 316275011871 HMMPfam hit to PF02595, Glycerate kinase family, score 5.5e-237 316275011872 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011873 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 316275011874 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 316275011875 substrate binding site [chemical binding]; other site 316275011876 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 316275011877 substrate binding site [chemical binding]; other site 316275011878 ligand binding site [chemical binding]; other site 316275011879 HMMPfam hit to PF00330, Aconitase family (aconitate hydratase), score 6.2e-12 316275011880 PS01244 Aconitase family signature 2. 316275011881 PS00450 Aconitase family signature 1. 316275011882 HMMPfam hit to PF06434, Aconitate hydratase, score 4.9e-259 316275011883 CDS is disrupted by the insertion of an IS element after codon 746. There is an inframe translational stop codon 2 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275011884 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275011885 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275011886 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275011887 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 5.5e-08 316275011888 HMMPfam hit to PF01734, Patatin-like phospholipase, score 1.7e-44 316275011889 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275011890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275011891 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275011892 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275011893 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275011894 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275011895 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275011896 Similar to Vibrio fischeri Methyl-accepting chemotaxis protein UniProt:Q5E2U0 (498 aa) fasta scores: E()=2.5e-150, 89.452% id in 493 aa. CDS contains a frameshift after codon 9. The sequence has been checked and is believed to be correct 316275011898 HMMPfam hit to PF08269, Cache domain, score 4.6e-22 316275011899 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1e-56 316275011900 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 316275011901 Transglycosylase; Region: Transgly; pfam00912 316275011902 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 316275011903 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 1.4e-21 316275011904 HMMPfam hit to PF00912, Transglycosylase, score 2.1e-83 316275011906 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 316275011907 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275011908 ATP binding site [chemical binding]; other site 316275011909 putative Mg++ binding site [ion binding]; other site 316275011910 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275011911 nucleotide binding region [chemical binding]; other site 316275011912 ATP-binding site [chemical binding]; other site 316275011913 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 316275011914 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 316275011915 HMMPfam hit to PF08482, ATP-dependent helicase C-terminal, score 1.4e-85 316275011916 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.5e-14 316275011917 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.4e-05 316275011918 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011919 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 316275011920 HMMPfam hit to PF03749, Sugar fermentation stimulation protein, score 8.2e-98 316275011921 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 316275011922 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 7.2e-33 316275011923 PS01102 Prokaryotic dksA/traR C4-type zinc finger. 316275011924 Similar to Escherichia coli Glutamyl-Q tRNA(Asp) synthetase GluQ UniProt:P27305 (298 aa) fasta scores: E()=3.4e-63, 55.219% id in 297 aa. CDS contains a frameshift after codon 34. The sequence has been checked and is believed to be correct 316275011925 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 5.3e-17 316275011926 poly(A) polymerase; Region: pcnB; TIGR01942 316275011927 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316275011928 active site 316275011929 NTP binding site [chemical binding]; other site 316275011930 metal binding triad [ion binding]; metal-binding site 316275011931 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316275011932 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 316275011933 HMMPfam hit to PF01743, Poly A polymerase family, score 3.7e-66 316275011934 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 316275011935 catalytic center binding site [active] 316275011936 ATP binding site [chemical binding]; other site 316275011937 HMMPfam hit to PF01288, 7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 3.3e-69 316275011938 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 316275011939 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 316275011940 oligomerization interface [polypeptide binding]; other site 316275011941 active site 316275011942 metal binding site [ion binding]; metal-binding site 316275011943 HMMPfam hit to PF02548, Ketopantoate hydroxymethyltransferase, score 1e-147 316275011944 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011945 pantoate--beta-alanine ligase; Region: panC; TIGR00018 316275011946 Pantoate-beta-alanine ligase; Region: PanC; cd00560 316275011947 active site 316275011948 ATP-binding site [chemical binding]; other site 316275011949 pantoate-binding site; other site 316275011950 HXXH motif; other site 316275011951 HMMPfam hit to PF02569, Pantoate-beta-alanine ligase, score 8.2e-123 316275011952 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275011953 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275011954 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275011955 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275011956 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275011957 Similar to Shewanella sp. Transposase IS66 UniProt:Q3IIG1 (115 aa) fasta scores: E()=4.8e-22, 50.0% id in 116 aa. CDS contains a frameshift after codon 61 316275011958 inner membrane transport permease; Provisional; Region: PRK15066 316275011959 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 316275011961 HMMPfam hit to PF01061, ABC-2 type transporter score 4.9e-47 316275011962 PS00890 ABC-2 type transport system integral membrane proteins signature. 316275011963 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 316275011964 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316275011965 Walker A/P-loop; other site 316275011966 ATP binding site [chemical binding]; other site 316275011967 Q-loop/lid; other site 316275011968 ABC transporter signature motif; other site 316275011969 Walker B; other site 316275011970 D-loop; other site 316275011971 H-loop/switch region; other site 316275011972 HMMPfam hit to PF00005, ABC transporter score 1.4e-55 316275011973 PS00211 ABC transporters family signature. 316275011974 PS00017 ATP/GTP-binding site motif A (P-loop). 316275011975 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 316275011976 active site clefts [active] 316275011977 zinc binding site [ion binding]; other site 316275011978 dimer interface [polypeptide binding]; other site 316275011979 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.8e-53 316275011980 PS00704 Prokaryotic-type carbonic anhydrases signature 1. 316275011981 PS00705 Prokaryotic-type carbonic anhydrases signature 2. 316275011982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 316275011983 active site 316275011984 HMMPfam hit to PF00156, Phosphoribosyl transferase domain, score 1.9e-36 316275011985 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 316275011986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275011987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275011988 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.7e-13 316275011989 Predicted helix-turn-helix motif with score 1352.000, SD 3.79 at aa 37-58, sequence GGHADIAEIAQVSVATVFNYFP 316275011990 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=3e-120, 56.680% id in 494 aa. CDS contains a frameshift after codon 97 316275011991 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) orphan protein transposase (is66 family element,orf2-like). UniProt:Q3IIG1 (EMBL:CR954246) (115 aa) fasta scores: E()=3.5e-25, 50.435% id in 115 aa. CDS contains a frameshift after codon 70 316275011992 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 316275011993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316275011994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275011995 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316275011996 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 1.9e-51 316275011997 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 0.00049 316275011998 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 2.2e-69 316275011999 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 1e-24 316275012000 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 316275012001 Similar to Escherichia coli Dihydrolipoyllysine-residue acetyltransferase component of pyruvat dehydrogenase complex AceF UniProt:P06959 (EMBL:V01498 (629 aa) fasta scores: E()=2.1e-128, 71.887% id in 530 aa. The CDS appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275012002 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 1.3e-118 316275012003 HMMPfam hit to PF02817, e3 binding domain, score 8.6e-17 316275012004 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 5.2e-28 316275012005 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 316275012006 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 2.2e-27 316275012007 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 316275012008 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 316275012009 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 316275012010 dimer interface [polypeptide binding]; other site 316275012011 TPP-binding site [chemical binding]; other site 316275012012 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 4.1e-09 316275012013 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 316275012014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316275012015 DNA-binding site [nucleotide binding]; DNA binding site 316275012016 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 316275012017 HMMPfam hit to PF07729, FCD domain, score 4.4e-27 316275012018 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 5.1e-32 316275012019 PS00043 Bacterial regulatory proteins, gntR family signature. 316275012020 Predicted helix-turn-helix motif with score 1124.000, SD 3.02 at aa 35-56, sequence PAERELAKQFDVSRPSVREAIQ 316275012021 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 316275012022 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 316275012023 amidase catalytic site [active] 316275012024 substrate binding site [chemical binding]; other site 316275012025 Zn binding residues [ion binding]; other site 316275012026 HMMPfam hit to PF01510, N-acetylmuramoyl-L-alanine amidase, score 8.6e-54 316275012027 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 316275012028 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 316275012029 dimerization interface [polypeptide binding]; other site 316275012030 active site 316275012031 HMMPfam hit to PF02749, Quinolinate phosphoribosyl transferase, N-t, score 5.8e-37 316275012032 HMMPfam hit to PF01729, Quinolinate phosphoribosyl transferase, C-t, score 3.8e-85 316275012033 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 316275012034 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 316275012035 Pilin (bacterial filament); Region: Pilin; pfam00114 316275012036 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.6e-09 316275012037 PS00409 Prokaryotic N-terminal methylation site. 316275012039 HMMPfam hit to PF00114, Pilin (bacterial filament), score 4.7e-05 316275012040 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 316275012041 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 316275012042 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316275012043 Walker A motif; other site 316275012044 ATP binding site [chemical binding]; other site 316275012045 Walker B motif; other site 316275012046 HMMPfam hit to PF05157, GSPII_E N-terminal domain, score 7.3e-21 316275012047 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 9.1e-143 316275012048 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012049 PS00662 Bacterial type II secretion system protein E signature. 316275012050 Similar to Vibrio cholerae Type IV pilin assembly protein PilC UniProt:Q9X4G9 (408 aa) fasta scores: E()=9.3e-53, 60.729% id in 247 aa. CDS contains a frameshift after codon 250. The sequence has been checked and is believed to be correct 316275012051 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 6e-23 316275012052 PS00874 Bacterial type II secretion system protein F signature. 316275012054 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.2e-15 316275012055 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 316275012056 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 316275012057 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 316275012059 HMMPfam hit to PF06750, Bacterial Peptidase A24 N-terminal doma, score 4.2e-44 316275012060 HMMPfam hit to PF01478, Type IV leader peptidase family, score 2e-26 316275012061 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 316275012062 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 316275012063 CoA-binding site [chemical binding]; other site 316275012064 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 2.3e-94 316275012065 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012066 PS01294 Uncharacterized protein family UPF0038 signature. 316275012067 hypothetical protein; Provisional; Region: PRK05287 316275012068 HMMPfam hit to PF07072, Protein of unknown function (DUF1342), score 1.5e-119 316275012069 DNA gyrase inhibitor; Reviewed; Region: PRK00418 316275012070 HMMPfam hit to PF03884, Domain of unknown function (DUF329), score 2.2e-33 316275012071 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 316275012072 active site 316275012073 8-oxo-dGMP binding site [chemical binding]; other site 316275012074 nudix motif; other site 316275012075 metal binding site [ion binding]; metal-binding site 316275012076 HMMPfam hit to PF00293, NUDIX domain, score 2.2e-21 316275012077 PS00893 mutT domain signature. 316275012078 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 316275012079 DEAD/DEAH box helicase; Region: DEAD; pfam00270 316275012080 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 316275012081 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 316275012082 SEC-C motif; Region: SEC-C; pfam02810 316275012083 HMMPfam hit to PF02810, SEC-C motif, score 1.7e-07 316275012084 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 9.9e-106 316275012085 PS01312 Protein secA signatures. 316275012086 HMMPfam hit to PF07517, SecA DEAD-like domain, score 3.8e-215 316275012087 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 1.4e-78 316275012088 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275012089 Protein of unknown function (DUF721); Region: DUF721; cl02324 316275012090 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 316275012091 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 316275012092 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 2.6e-180 316275012093 cell division protein FtsZ; Validated; Region: PRK09330 316275012094 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 316275012095 nucleotide binding site [chemical binding]; other site 316275012096 SulA interaction site; other site 316275012097 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 316275012098 HMMPfam hit to PF03953, Tubulin/FtsZ family, C-terminal domain, score 4.6e-42 316275012099 HMMPfam hit to PF00091, Tubulin/FtsZ family, GTPase domain, score 8.1e-92 316275012100 PS01135 FtsZ protein signature 2. 316275012101 PS01134 FtsZ protein signature 1. 316275012102 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 316275012103 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316275012104 nucleotide binding site [chemical binding]; other site 316275012105 Cell division protein FtsA; Region: FtsA; pfam14450 316275012106 HMMPfam hit to PF02491, Cell division protein FtsA, score 2.6e-74 316275012107 HMMPfam hit to PF02491, Cell division protein FtsA, score 3.1e-74 316275012108 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 316275012109 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 316275012110 Cell division protein FtsQ; Region: FtsQ; pfam03799 316275012111 HMMPfam hit to PF03799, Cell division protein FtsQ, score 9.9e-14 316275012112 HMMPfam hit to PF08478, POTRA domain, FtsQ-type, score 1.6e-22 316275012114 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 316275012115 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316275012116 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316275012117 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316275012118 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 2.5e-23 316275012119 HMMPfam hit to PF08245, Mur ligase middle domain, score 6.5e-31 316275012120 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 8.9e-44 316275012121 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 316275012122 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 316275012123 active site 316275012124 homodimer interface [polypeptide binding]; other site 316275012125 HMMPfam hit to PF04101, Glycosyltransferase family, score 1.7e-37 316275012126 HMMPfam hit to PF03033, Glycosyltransferase family, score 3.3e-48 316275012127 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 316275012128 HMMPfam hit to PF01098, Cell cycle protein, score 1.5e-153 316275012130 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 316275012131 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012132 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04663 316275012133 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316275012134 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316275012135 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 4.8e-10 316275012136 PS00589 PTS HPR component serine phosphorylation site signature. 316275012137 HMMPfam hit to PF08245, Mur ligase middle domain, score 3.9e-54 316275012138 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 316275012139 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 316275012140 Mg++ binding site [ion binding]; other site 316275012141 putative catalytic motif [active] 316275012142 putative substrate binding site [chemical binding]; other site 316275012144 HMMPfam hit to PF00953, Glycosyl transferase family, score 6.7e-80 316275012145 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 316275012146 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316275012147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316275012148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316275012149 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 6.3e-10 316275012150 HMMPfam hit to PF08245, Mur ligase middle domain, score 2.7e-62 316275012151 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 6.4e-16 316275012152 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 316275012153 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 316275012154 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 316275012155 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 316275012156 HMMPfam hit to PF02875, Mur ligase family, glutamate ligase doma, score 3.5e-30 316275012157 HMMPfam hit to PF08245, Mur ligase middle domain, score 1.1e-65 316275012158 HMMPfam hit to PF01225, Mur ligase family, catalytic domain, score 8e-13 316275012159 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 316275012160 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 316275012161 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 316275012162 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 3e-104 316275012163 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 2.4e-59 316275012165 Cell division protein FtsL; Region: FtsL; pfam04999 316275012166 HMMPfam hit to PF04999, Cell division protein FtsL, score 4.6e-35 316275012168 MraW methylase family; Region: Methyltransf_5; pfam01795 316275012169 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 316275012170 HMMPfam hit to PF01795, MraW methylase family, score 4.7e-158 316275012171 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 316275012172 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 316275012173 putative SAM binding site [chemical binding]; other site 316275012174 putative homodimer interface [polypeptide binding]; other site 316275012175 HMMPfam hit to PF00590, Tetrapyrrole (Corrin/Porphyrin) Methylas, score 7.6e-59 316275012176 PS01296 Uncharacterized protein family UPF0011 signature. 316275012177 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 316275012178 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 316275012179 putative ligand binding site [chemical binding]; other site 316275012180 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275012181 HMMPfam hit to PF04348, LppC lipoprotein, score 6.2e-175 316275012182 hypothetical protein; Reviewed; Region: PRK12497 316275012183 HMMPfam hit to PF02021, Uncharacterised protein family UPF0102, score 9.9e-33 316275012184 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 316275012185 dimer interface [polypeptide binding]; other site 316275012186 active site 316275012187 outer membrane lipoprotein; Provisional; Region: PRK11023 316275012188 BON domain; Region: BON; pfam04972 316275012189 BON domain; Region: BON; pfam04972 316275012191 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275012192 HMMPfam hit to PF04972, phospholipid-binding domain, score 5.6e-07 316275012193 HMMPfam hit to PF04972, phospholipid-binding domain, score 1.2e-07 316275012194 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 316275012195 HMMPfam hit to PF04386, Stringent starvation protein B, score 2.1e-79 316275012196 stringent starvation protein A; Provisional; Region: sspA; PRK09481 316275012197 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 316275012198 C-terminal domain interface [polypeptide binding]; other site 316275012199 putative GSH binding site (G-site) [chemical binding]; other site 316275012200 dimer interface [polypeptide binding]; other site 316275012201 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 316275012202 dimer interface [polypeptide binding]; other site 316275012203 N-terminal domain interface [polypeptide binding]; other site 316275012204 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal domain, score 5.7e-06 316275012205 HMMPfam hit to PF02798, Glutathione S-transferase, N-terminal domain, score 1.1e-19 316275012206 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 316275012207 HMMPfam hit to PF02167, Cytochrome C1 family, score 1.2e-07 316275012209 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275012210 PS00190 Cytochrome c family heme-binding site signature. 316275012211 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 316275012212 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 316275012213 Qi binding site; other site 316275012214 intrachain domain interface; other site 316275012215 interchain domain interface [polypeptide binding]; other site 316275012216 heme bH binding site [chemical binding]; other site 316275012217 heme bL binding site [chemical binding]; other site 316275012218 Qo binding site; other site 316275012219 interchain domain interface [polypeptide binding]; other site 316275012220 intrachain domain interface; other site 316275012221 Qi binding site; other site 316275012222 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 316275012223 Qo binding site; other site 316275012225 HMMPfam hit to PF00032, Cytochrome b(C-terminal)/b6/petD, score 8.1e-29 316275012226 HMMPfam hit to PF00033, Cytochrome b(N-terminal)/b6/petB, score 3.2e-84 316275012227 PS00192 Cytochrome b/b6 heme-ligand signature. 316275012228 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 316275012229 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 316275012230 [2Fe-2S] cluster binding site [ion binding]; other site 316275012231 HMMPfam hit to PF00355, Rieske [2Fe-2S] domain, score 4.3e-07 316275012232 PS00200 Rieske iron-sulfur protein signature 2. 316275012233 PS00199 Rieske iron-sulfur protein signature 1. 316275012235 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 316275012236 HMMPfam hit to PF00380, Ribosomal protein S9/S16, score 5.7e-69 316275012237 PS00360 Ribosomal protein S9 signature. 316275012238 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 316275012239 23S rRNA interface [nucleotide binding]; other site 316275012240 L3 interface [polypeptide binding]; other site 316275012241 HMMPfam hit to PF00572, Ribosomal protein L13, score 9.1e-76 316275012242 PS00783 Ribosomal protein L13 signature. 316275012243 Predicted ATPase [General function prediction only]; Region: COG1485 316275012244 HMMPfam hit to PF03969, AFG1-like ATPase, score 1e-197 316275012245 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012246 hypothetical protein; Provisional; Region: PRK11677 316275012247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 316275012249 HMMPfam hit to PF06295, Protein of unknown function (DUF1043), score 6.6e-57 316275012250 serine endoprotease; Provisional; Region: PRK10942 316275012251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316275012252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316275012253 protein binding site [polypeptide binding]; other site 316275012254 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316275012256 HMMPfam hit to PF00089, Trypsin, score 1.7e-20 316275012257 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2.2e-20 316275012258 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 3.4e-08 316275012259 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 316275012260 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 316275012261 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316275012262 HMMPfam hit to PF00089, Trypsin, score 1.5e-17 316275012263 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1e-05 316275012264 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 316275012265 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 316275012266 CAP-like domain; other site 316275012267 active site 316275012268 primary dimer interface [polypeptide binding]; other site 316275012269 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 316275012270 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.2e-06 316275012271 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 0.038 316275012272 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV, subunit A, score 4.3e-243 316275012273 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 316275012274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275012275 ATP binding site [chemical binding]; other site 316275012276 Mg2+ binding site [ion binding]; other site 316275012277 G-X-G motif; other site 316275012278 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 316275012279 anchoring element; other site 316275012280 dimer interface [polypeptide binding]; other site 316275012281 ATP binding site [chemical binding]; other site 316275012282 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 316275012283 active site 316275012284 putative metal-binding site [ion binding]; other site 316275012285 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 316275012286 HMMPfam hit to PF00986, DNA gyrase B subunit, carboxyl terminus, score 5.6e-33 316275012287 PS00177 DNA topoisomerase II signature. 316275012288 HMMPfam hit to PF00204, DNA gyrase B, score 1.7e-51 316275012289 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 3.3e-25 316275012290 esterase YqiA; Provisional; Region: PRK11071 316275012291 HMMPfam hit to PF05728, Uncharacterised protein family (UPF0227), score 5.4e-91 316275012292 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 316275012293 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 316275012294 active site 316275012295 metal binding site [ion binding]; metal-binding site 316275012296 hexamer interface [polypeptide binding]; other site 316275012297 HMMPfam hit to PF08413, Calcineurin-like phosphoesterase C-term, score 1.1e-39 316275012298 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 5.5e-14 316275012299 putative dehydrogenase; Provisional; Region: PRK11039 316275012300 HMMPfam hit to PF06853, Protein of unknown function (DUF1249), score 7e-64 316275012301 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 316275012302 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 316275012303 dimer interface [polypeptide binding]; other site 316275012304 ADP-ribose binding site [chemical binding]; other site 316275012305 active site 316275012306 nudix motif; other site 316275012307 metal binding site [ion binding]; metal-binding site 316275012308 HMMPfam hit to PF00293, NUDIX domain, score 4.4e-19 316275012309 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 316275012310 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.5e-29 316275012311 HMMPfam hit to PF02321, Outer membrane efflux protein, score 2.3e-34 316275012312 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 316275012313 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 316275012314 putative ribose interaction site [chemical binding]; other site 316275012315 putative ADP binding site [chemical binding]; other site 316275012316 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 316275012317 active site 316275012318 HIGH motif; other site 316275012319 nucleotide binding site [chemical binding]; other site 316275012320 HMMPfam hit to PF01467, Cytidylyltransferase, score 3.4e-20 316275012321 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 7.8e-40 316275012322 PS00583 pfkB family of carbohydrate kinases signature 1. 316275012323 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 316275012324 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316275012325 metal binding triad; other site 316275012326 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 316275012327 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316275012328 metal binding triad; other site 316275012329 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 6.2e-121 316275012330 HMMPfam hit to PF03710, Glutamate-ammonia ligase adenylyltransferase, score 4e-123 316275012331 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275012332 dimerization interface [polypeptide binding]; other site 316275012333 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275012334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275012335 dimer interface [polypeptide binding]; other site 316275012336 putative CheW interface [polypeptide binding]; other site 316275012337 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 8.4e-62 316275012338 HMMPfam hit to PF00672, HAMP domain, score 1.3e-08 316275012340 Ion transport protein; Region: Ion_trans; pfam00520 316275012341 Ion channel; Region: Ion_trans_2; pfam07885 316275012343 HMMPfam hit to PF00520, Ion transport protein, score 1.3e-20 316275012344 HMMPfam hit to PF07885, Ion channel, score 6.3e-19 316275012345 Uncharacterized conserved protein [Function unknown]; Region: COG3025 316275012346 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 316275012347 putative active site [active] 316275012348 putative metal binding residues [ion binding]; other site 316275012349 signature motif; other site 316275012350 putative triphosphate binding site [ion binding]; other site 316275012351 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 316275012352 HMMPfam hit to PF01928, CYTH domain, score 1.2e-51 316275012353 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 316275012354 HMMPfam hit to PF01865, Protein of unknown function DUF47, score 1.4e-86 316275012355 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 316275012356 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 316275012358 HMMPfam hit to PF01384, Phosphate transporter family, score 2.9e-174 316275012359 Bacterial SH3 domain homologues; Region: SH3b; smart00287 316275012360 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 316275012361 HMMPfam hit to PF08239, Bacterial SH3 domain, score 0.00037 316275012363 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275012364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012365 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275012366 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275012367 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275012368 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275012369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012371 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 316275012372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275012373 Walker A motif; other site 316275012374 ATP binding site [chemical binding]; other site 316275012375 Walker B motif; other site 316275012376 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 316275012377 HMMPfam hit to PF01471, peptidoglycan binding domain, score 3.2e-09 316275012378 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012379 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 316275012380 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 316275012381 active site 316275012382 NTP binding site [chemical binding]; other site 316275012383 metal binding triad [ion binding]; metal-binding site 316275012384 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 316275012385 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275012386 Zn2+ binding site [ion binding]; other site 316275012387 Mg2+ binding site [ion binding]; other site 316275012388 HMMPfam hit to PF01743, Poly A polymerase family, score 1.1e-58 316275012389 HMMPfam hit to PF01966, HD domain, score 1.5e-07 316275012390 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 316275012392 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 5.8e-116 316275012393 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 316275012394 catalytic center binding site [active] 316275012395 ATP binding site [chemical binding]; other site 316275012396 HMMPfam hit to PF01288, 7,8-dihydro-6-hydroxymethylpterin-pyrophosph, score 4.5e-18 316275012397 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 316275012398 homooctamer interface [polypeptide binding]; other site 316275012399 active site 316275012400 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 3.4e-42 316275012401 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 316275012403 HMMPfam hit to PF02660, Domain of unknown function DUF, score 1.3e-84 316275012404 UGMP family protein; Validated; Region: PRK09604 316275012405 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 316275012406 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 316275012407 HMMPfam hit to PF00814, Glycoprotease family, score 4.2e-75 316275012408 PS01016 Glycoprotease family signature. 316275012409 Yqey-like protein; Region: YqeY; pfam09424 316275012410 HMMPfam hit to PF02637, GatB/Yqey domain, score 8.4e-34 316275012411 DNA primase; Validated; Region: dnaG; PRK05667 316275012412 CHC2 zinc finger; Region: zf-CHC2; pfam01807 316275012413 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 316275012414 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 316275012415 active site 316275012416 metal binding site [ion binding]; metal-binding site 316275012417 interdomain interaction site; other site 316275012418 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 316275012419 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 316275012420 HMMPfam hit to PF01807, CHC2 zinc finger, score 2.6e-65 316275012421 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 3.5e-62 316275012422 HMMPfam hit to PF01751, Toprim domain, score 5.2e-24 316275012423 HMMPfam hit to PF08278, DNA primase DnaG DnaB-binding, score 8.1e-56 316275012424 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 316275012425 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 316275012426 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316275012427 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 316275012428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316275012429 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316275012430 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316275012431 DNA binding residues [nucleotide binding] 316275012432 HMMPfam hit to PF03979, Sigma-70 factor, region, score 9.9e-40 316275012433 HMMPfam hit to PF00140, Sigma-70 factor, region, score 2.8e-15 316275012434 HMMPfam hit to PF04546, Sigma-70, non-essential region, score 1.4e-96 316275012435 Predicted helix-turn-helix motif with score 1917.000, SD 5.72 at aa 353-374, sequence VNIKDISRRMSIGEAKARRAKK 316275012436 HMMPfam hit to PF04542, Sigma-70 region, score 2e-28 316275012437 PS00715 Sigma-70 factors family signature 1. 316275012438 HMMPfam hit to PF04539, Sigma-70 region, score 3.1e-40 316275012439 HMMPfam hit to PF04545, Sigma-70, region, score 2e-23 316275012440 Predicted helix-turn-helix motif with score 1917.000, SD 5.72 at aa 568-589, sequence HTLEEVGKQFDVTRERIRQIEA 316275012441 PS00716 Sigma-70 factors family signature 2. 316275012442 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E2J6 (206 aa) fasta scores: E()=6.1e-64, 80.583% id in 206 aa. CDS contains a frameshift after codon 84. The sequence has been checked and is believed to be correct 316275012443 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 316275012444 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 316275012445 acyl-activating enzyme (AAE) consensus motif; other site 316275012446 putative AMP binding site [chemical binding]; other site 316275012447 putative active site [active] 316275012448 putative CoA binding site [chemical binding]; other site 316275012449 HMMPfam hit to PF00501, AMP-binding enzyme, score 7e-131 316275012450 PS00455 AMP-binding domain signature. 316275012452 pyruvate kinase; Provisional; Region: PRK09206 316275012453 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 316275012454 domain interfaces; other site 316275012455 active site 316275012456 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 2.8e-215 316275012457 PS00110 Pyruvate kinase active site signature. 316275012458 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 3.5e-21 316275012459 Transcriptional regulators [Transcription]; Region: GntR; COG1802 316275012460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316275012461 DNA-binding site [nucleotide binding]; DNA binding site 316275012462 FCD domain; Region: FCD; pfam07729 316275012463 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 4.9e-13 316275012465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316275012466 PAS domain; Region: PAS_9; pfam13426 316275012467 putative active site [active] 316275012468 heme pocket [chemical binding]; other site 316275012469 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275012470 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275012471 metal binding site [ion binding]; metal-binding site 316275012472 active site 316275012473 I-site; other site 316275012474 HMMPfam hit to PF00990, GGDEF domain, score 2.9e-28 316275012475 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012476 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 316275012478 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 316275012479 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 316275012480 putative valine binding site [chemical binding]; other site 316275012481 dimer interface [polypeptide binding]; other site 316275012482 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 316275012483 HMMPfam hit to PF01842, ACT domain, score 5.8e-16 316275012484 PS00430 TonB-dependent receptor proteins signature 1. 316275012485 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979 316275012486 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 316275012487 PYR/PP interface [polypeptide binding]; other site 316275012488 dimer interface [polypeptide binding]; other site 316275012489 TPP binding site [chemical binding]; other site 316275012490 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 316275012491 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 316275012492 TPP-binding site [chemical binding]; other site 316275012493 dimer interface [polypeptide binding]; other site 316275012494 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-termina, score 4.3e-74 316275012495 PS00187 Thiamine pyrophosphate enzymes signature. 316275012496 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central d, score 7.5e-59 316275012497 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-termina, score 1.5e-100 316275012498 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275012499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012500 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275012501 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275012502 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275012503 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275012504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012505 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 316275012506 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 316275012507 active sites [active] 316275012508 tetramer interface [polypeptide binding]; other site 316275012509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275012510 Coenzyme A binding pocket [chemical binding]; other site 316275012511 HMMPfam hit to PF00206, Lyase, score 1.2e-111 316275012512 PS00163 Fumarate lyases signature. 316275012513 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 4.7e-10 316275012514 Protein of unknown function (DUF3624); Region: DUF3624; pfam12292 316275012516 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 316275012517 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275012518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275012519 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316275012520 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 6.4e-07 316275012521 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 0.0004 316275012522 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 6.5e-36 316275012523 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 9.3e-07 316275012524 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 316275012525 catalytic triad [active] 316275012526 dimer interface [polypeptide binding]; other site 316275012527 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316275012528 HMMPfam hit to PF00462, Glutaredoxin, score 2e-23 316275012529 PS00195 Glutaredoxin active site. 316275012530 HMMPfam hit to PF08534, Redoxin, score 2.6e-43 316275012531 HMMPfam hit to PF00578, AhpC/TSA family, score 3.9e-06 316275012532 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 316275012533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275012534 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 316275012535 dimerization interface [polypeptide binding]; other site 316275012536 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.9e-22 316275012537 Predicted helix-turn-helix motif with score 1510.000, SD 4.33 at aa 16-37, sequence KHFRKAAESCFVSQPTLSGQIK 316275012538 PS00044 Bacterial regulatory proteins, lysR family signature. 316275012539 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.5e-49 316275012540 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 316275012541 Transglycosylase; Region: Transgly; pfam00912 316275012542 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 316275012543 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012544 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 4.9e-21 316275012545 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012546 HMMPfam hit to PF00912, Transglycosylase, score 1.1e-83 316275012548 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 316275012549 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 316275012550 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 316275012551 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 316275012552 HMMPfam hit to PF05137, Fimbrial assembly protein (PilN), score 2.9e-40 316275012554 Pilus assembly protein, PilO; Region: PilO; pfam04350 316275012556 HMMPfam hit to PF04350, Pilus assembly protein, PilO, score 6.1e-56 316275012557 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 316275012558 Pilus assembly protein, PilP; Region: PilP; pfam04351 316275012559 HMMPfam hit to PF04351, Pilus assembly protein, PilP, score 1.2e-35 316275012560 Similar to Pseudomonas aeruginosa Fimbrial assembly protein PilQ UniProt:P34750 (714 aa) fasta scores: E()=4.8e-36, 40.073% id in 549 aa. CDS is disrupted by the insertion of an IS element after codon 446 316275012562 HMMPfam hit to PF07660, Secretin and TonB N terminus short domain, score 3e-09 316275012563 HMMPfam hit to PF00263, Bacterial type II and III secretion system p, score 2.2e-81 316275012564 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275012565 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275012566 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275012567 PS00875 Bacterial type II secretion system protein D signature. 316275012568 shikimate kinase; Reviewed; Region: aroK; PRK00131 316275012569 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 316275012570 ADP binding site [chemical binding]; other site 316275012571 magnesium binding site [ion binding]; other site 316275012572 putative shikimate binding site; other site 316275012573 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012574 HMMPfam hit to PF01202, Shikimate kinase, score 1.7e-78 316275012575 PS01128 Shikimate kinase signature. 316275012576 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 316275012577 active site 316275012578 dimer interface [polypeptide binding]; other site 316275012579 metal binding site [ion binding]; metal-binding site 316275012580 HMMPfam hit to PF01761, 3-dehydroquinate synthase, score 1.9e-175 316275012581 AAA domain; Region: AAA_22; pfam13401 316275012582 cell division protein DamX; Validated; Region: PRK10905 316275012583 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012585 HMMPfam hit to PF05036, Sporulation related domain, score 6.1e-10 316275012586 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 316275012587 HMMPfam hit to PF02086, D12 class N6 adenine-specific DNA met, score 5.1e-89 316275012588 PS00092 N-6 Adenine-specific DNA methylases signature. 316275012589 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 316275012590 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 316275012591 substrate binding site [chemical binding]; other site 316275012592 hexamer interface [polypeptide binding]; other site 316275012593 metal binding site [ion binding]; metal-binding site 316275012594 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 2.9e-137 316275012595 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase /, score 0.00052 316275012596 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 316275012597 PS01086 Ribulose-phosphate 3-epimerase family signature 2. 316275012598 phosphoglycolate phosphatase; Provisional; Region: PRK13222 316275012599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275012600 motif II; other site 316275012601 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1e-30 316275012602 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 316275012603 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 316275012604 active site 316275012605 HIGH motif; other site 316275012606 dimer interface [polypeptide binding]; other site 316275012607 KMSKS motif; other site 316275012608 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 3.1e-98 316275012609 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 316275012610 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 316275012611 glutamine binding [chemical binding]; other site 316275012612 catalytic triad [active] 316275012613 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.8e-91 316275012614 PS00442 Glutamine amidotransferases class-I active site. 316275012615 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275012616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012617 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275012618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012619 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275012620 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275012621 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275012622 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 316275012623 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316275012624 inhibitor-cofactor binding pocket; inhibition site 316275012625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275012626 catalytic residue [active] 316275012627 HMMPfam hit to PF00202, Aminotransferase class-III, score 5.3e-147 316275012628 PS00196 Type-1 copper (blue) proteins signature. 316275012629 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 316275012630 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 316275012631 HMMPfam hit to PF04958, Arginine N-succinyltransferase beta subunit, score 4.4e-204 316275012632 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 316275012633 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 316275012634 NAD(P) binding site [chemical binding]; other site 316275012635 catalytic residues [active] 316275012636 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 9.8e-122 316275012637 PS00687 Aldehyde dehydrogenases glutamic acid active site. 316275012638 PS00070 Aldehyde dehydrogenases cysteine active site. 316275012639 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 316275012640 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 316275012641 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316275012642 ligand binding site [chemical binding]; other site 316275012643 flexible hinge region; other site 316275012644 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 316275012645 putative switch regulator; other site 316275012646 non-specific DNA interactions [nucleotide binding]; other site 316275012647 DNA binding site [nucleotide binding] 316275012648 sequence specific DNA binding site [nucleotide binding]; other site 316275012649 putative cAMP binding site [chemical binding]; other site 316275012650 HMMPfam hit to PF00325, Bacterial regulatory proteins, crp famil, score 7.7e-16 316275012651 PS00042 Bacterial regulatory proteins, crp family signature. 316275012652 Predicted helix-turn-helix motif with score 2127.000, SD 6.43 at aa 168-189, sequence ITRQEIGQIVGCSRETVGRILK 316275012653 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 4.3e-27 316275012654 PS00889 Cyclic nucleotide-binding domain signature 2. 316275012655 PS00888 Cyclic nucleotide-binding domain signature 1. 316275012656 OsmC-like protein; Region: OsmC; cl00767 316275012657 HMMPfam hit to PF02566, OsmC-like protein, score 4.8e-21 316275012658 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 316275012659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275012660 Walker A motif; other site 316275012661 ATP binding site [chemical binding]; other site 316275012662 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 316275012663 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 316275012664 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 7.5e-48 316275012665 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012666 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 316275012667 active site 316275012668 HslU subunit interaction site [polypeptide binding]; other site 316275012669 HMMPfam hit to PF00227, Proteasome A-type and B-type, score 7.5e-32 316275012670 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 316275012671 Sporulation related domain; Region: SPOR; pfam05036 316275012672 HMMPfam hit to PF05036, Sporulation related domain, score 1.1e-15 316275012674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275012675 DNA binding site [nucleotide binding] 316275012676 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 316275012677 domain linker motif; other site 316275012678 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 316275012679 dimerization interface [polypeptide binding]; other site 316275012680 ligand binding site [chemical binding]; other site 316275012681 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 7e-30 316275012682 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2.3e-10 316275012683 Predicted helix-turn-helix motif with score 1511.000, SD 4.33 at aa 2-23, sequence ATMKDVALSAGVSTATVSRALM 316275012684 PS00356 Bacterial regulatory proteins, lacI family signature. 316275012685 primosome assembly protein PriA; Validated; Region: PRK05580 316275012686 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275012687 ATP binding site [chemical binding]; other site 316275012688 putative Mg++ binding site [ion binding]; other site 316275012689 helicase superfamily c-terminal domain; Region: HELICc; smart00490 316275012690 ATP-binding site [chemical binding]; other site 316275012691 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 5.8e-06 316275012692 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 4.5e-23 316275012693 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 5e-08 316275012694 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012695 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 316275012696 HMMPfam hit to PF01197, Ribosomal protein L31, score 4.8e-37 316275012697 PS01143 Ribosomal protein L31 signature. 316275012698 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 316275012699 Malic enzyme, N-terminal domain; Region: malic; pfam00390 316275012700 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 316275012701 putative NAD(P) binding site [chemical binding]; other site 316275012702 HMMPfam hit to PF00390, Malic enzyme, N-terminal domain, score 1e-76 316275012703 PS00331 Malic enzymes signature. 316275012704 HMMPfam hit to PF03949, Malic enzyme, NAD binding domain, score 8e-131 316275012705 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 316275012706 dimerization interface [polypeptide binding]; other site 316275012707 DNA binding site [nucleotide binding] 316275012708 corepressor binding sites; other site 316275012709 HMMPfam hit to PF01340, Met Apo-repressor, MetJ, score 1.7e-68 316275012710 cystathionine gamma-synthase; Provisional; Region: PRK08861 316275012711 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 316275012712 homodimer interface [polypeptide binding]; other site 316275012713 substrate-cofactor binding pocket; other site 316275012714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275012715 catalytic residue [active] 316275012716 HMMPfam hit to PF01053, Cys/Met metabolism PLP-dependent enzy, score 2.5e-179 316275012717 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 316275012718 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 316275012719 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 316275012720 nucleotide binding site [chemical binding]; other site 316275012721 substrate binding site [chemical binding]; other site 316275012722 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 316275012723 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 316275012724 HMMPfam hit to PF00696, Amino acid kinase family, score 1.4e-39 316275012725 PS00324 Aspartokinase signature. 316275012726 HMMPfam hit to PF03447, Homoserine dehydrogenase, NAD binding d, score 5.3e-10 316275012727 HMMPfam hit to PF00742, Homoserine dehydrogenase, score 4.1e-81 316275012728 PS01042 Homoserine dehydrogenase signature. 316275012729 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 316275012730 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275012731 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 316275012732 putative substrate binding pocket [chemical binding]; other site 316275012733 putative dimerization interface [polypeptide binding]; other site 316275012734 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 3.9e-22 316275012735 Predicted helix-turn-helix motif with score 1756.000, SD 5.17 at aa 37-58, sequence QNITRAAQNLGMSQPAVSNAVS 316275012736 PS00044 Bacterial regulatory proteins, lysR family signature. 316275012737 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.6e-12 316275012738 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 316275012739 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 316275012740 acyl-activating enzyme (AAE) consensus motif; other site 316275012741 putative AMP binding site [chemical binding]; other site 316275012742 putative active site [active] 316275012743 putative CoA binding site [chemical binding]; other site 316275012744 HMMPfam hit to PF00501, AMP-binding enzyme, score 2.8e-84 316275012745 PS00455 AMP-binding domain signature. 316275012746 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275012747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012748 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275012749 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012750 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275012751 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275012752 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275012753 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 316275012754 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 316275012755 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 2e-229 316275012756 PS00393 Phosphoenolpyruvate carboxylase active site 2. 316275012757 PS00781 Phosphoenolpyruvate carboxylase active site 1. 316275012758 acetylornithine deacetylase; Provisional; Region: PRK05111 316275012759 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 316275012760 metal binding site [ion binding]; metal-binding site 316275012761 putative dimer interface [polypeptide binding]; other site 316275012762 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 3.3e-37 316275012763 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 3e-30 316275012764 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012765 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 316275012766 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 316275012767 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 316275012768 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 316275012769 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD bindi, score 9.6e-51 316275012770 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 316275012771 PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 316275012772 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisat, score 4.1e-27 316275012773 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 316275012774 nucleotide binding site [chemical binding]; other site 316275012775 substrate binding site [chemical binding]; other site 316275012776 HMMPfam hit to PF00696, Amino acid kinase family, score 3.5e-33 316275012777 argininosuccinate synthase; Provisional; Region: PRK13820 316275012778 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 316275012779 ANP binding site [chemical binding]; other site 316275012780 Substrate Binding Site II [chemical binding]; other site 316275012781 Substrate Binding Site I [chemical binding]; other site 316275012782 HMMPfam hit to PF00764, Arginosuccinate synthase, score 3.6e-181 316275012783 PS00564 Argininosuccinate synthase signature 1. 316275012784 PS00565 Argininosuccinate synthase signature 2. 316275012785 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275012786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012787 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275012788 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275012789 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275012790 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275012791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275012792 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 316275012793 FAD binding site [chemical binding]; other site 316275012794 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 1.6e-145 316275012795 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 316275012796 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 316275012797 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 316275012798 HMMPfam hit to PF03948, Ribosomal protein L9, C-terminal domai, score 1.2e-37 316275012799 HMMPfam hit to PF01281, Ribosomal protein L9, N-terminal domai, score 5e-23 316275012800 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 316275012801 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.1e-31 316275012802 PS00057 Ribosomal protein S18 signature. 316275012803 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 316275012804 dimer interface [polypeptide binding]; other site 316275012805 ssDNA binding site [nucleotide binding]; other site 316275012806 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316275012807 HMMPfam hit to PF00436, Single-strand binding protein family, score 4.4e-20 316275012808 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 316275012809 HMMPfam hit to PF01250, Ribosomal protein S6, score 9.4e-47 316275012810 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 316275012811 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 316275012812 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 316275012813 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 8.3e-56 316275012814 HMMPfam hit to PF08032, RNA 2'-O ribose methyltransferase subs, score 1.3e-21 316275012815 exoribonuclease R; Provisional; Region: PRK11642 316275012816 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 316275012817 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 316275012818 RNB domain; Region: RNB; pfam00773 316275012819 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 316275012820 RNA binding site [nucleotide binding]; other site 316275012821 HMMPfam hit to PF00575, S1 RNA binding domain, score 3.7e-20 316275012822 PS01175 Ribonuclease II family signature. 316275012823 HMMPfam hit to PF00773, RNB-like protein, score 2.7e-107 316275012824 HMMPfam hit to PF08206, Ribonuclease B OB domain, score 1.2e-23 316275012825 HMMPfam hit to PF08461, Ribonuclease R winged-helix domain, score 3.8e-16 316275012826 transcriptional repressor NsrR; Provisional; Region: PRK11014 316275012827 Rrf2 family protein; Region: rrf2_super; TIGR00738 316275012828 HMMPfam hit to PF02082, Transcriptional regulator, score 1.6e-42 316275012829 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 316275012830 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 316275012831 heme-binding site [chemical binding]; other site 316275012832 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 316275012833 FAD binding pocket [chemical binding]; other site 316275012834 FAD binding motif [chemical binding]; other site 316275012835 phosphate binding motif [ion binding]; other site 316275012836 beta-alpha-beta structure motif; other site 316275012837 NAD binding pocket [chemical binding]; other site 316275012838 Heme binding pocket [chemical binding]; other site 316275012839 HMMPfam hit to PF00042, Globin, score 6.6e-25 316275012840 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 6.1e-12 316275012841 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 4.3e-13 316275012842 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316275012843 Sel1-like repeats; Region: SEL1; smart00671 316275012844 HMMPfam hit to PF08238, Sel1 repeat, score 1.4e-05 316275012845 HMMPfam hit to PF08238, Sel1 repeat, score 0.16 316275012846 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 316275012847 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 316275012848 GDP-binding site [chemical binding]; other site 316275012849 ACT binding site; other site 316275012850 IMP binding site; other site 316275012851 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 0 316275012852 PS00513 Adenylosuccinate synthetase active site. 316275012853 PS01266 Adenylosuccinate synthetase GTP-binding site. 316275012854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 316275012856 FtsH protease regulator HflC; Provisional; Region: PRK11029 316275012857 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 316275012858 HMMPfam hit to PF01145, SPFH domain / Band, score 1.5e-58 316275012860 FtsH protease regulator HflK; Provisional; Region: PRK10930 316275012861 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 316275012862 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 316275012863 HMMPfam hit to PF01145, SPFH domain / Band, score 2.4e-44 316275012865 GTPase HflX; Provisional; Region: PRK11058 316275012866 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 316275012867 HflX GTPase family; Region: HflX; cd01878 316275012868 G1 box; other site 316275012869 GTP/Mg2+ binding site [chemical binding]; other site 316275012870 Switch I region; other site 316275012871 G2 box; other site 316275012872 G3 box; other site 316275012873 Switch II region; other site 316275012874 G4 box; other site 316275012875 G5 box; other site 316275012876 HMMPfam hit to PF01926, GTPase of unknown function, score 9.9e-40 316275012877 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012878 bacterial Hfq-like; Region: Hfq; cd01716 316275012879 hexamer interface [polypeptide binding]; other site 316275012880 Sm1 motif; other site 316275012881 RNA binding site [nucleotide binding]; other site 316275012882 Sm2 motif; other site 316275012883 HMMPfam hit to PF01423, LSM domain, score 1.5e-11 316275012884 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 316275012885 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 316275012886 HMMPfam hit to PF01715, IPP transferase, score 2.4e-146 316275012887 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012888 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 316275012889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275012890 ATP binding site [chemical binding]; other site 316275012891 Mg2+ binding site [ion binding]; other site 316275012892 G-X-G motif; other site 316275012893 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 316275012894 ATP binding site [chemical binding]; other site 316275012895 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 316275012896 HMMPfam hit to PF01119, DNA mismatch repair protein, C-termina, score 6.5e-41 316275012897 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and, score 1.1e-09 316275012898 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 316275012899 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 316275012900 AMIN domain; Region: AMIN; pfam11741 316275012901 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 316275012902 active site 316275012903 metal binding site [ion binding]; metal-binding site 316275012904 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275012905 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 316275012906 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275012907 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 316275012908 HMMPfam hit to PF01476, LysM domain, score 1.6e-16 316275012909 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 541-562, sequence EFLGKIASKYGVTVSSIRTANK 316275012910 HMMPfam hit to PF01476, LysM domain, score 5.5e-16 316275012911 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 491-512, sequence EYLGKIAVKYKVSTSSIRSLNR 316275012912 HMMPfam hit to PF01476, LysM domain, score 1.3e-16 316275012913 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 5.2e-79 316275012914 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 316275012915 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 2.2e-55 316275012916 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012917 epoxyqueuosine reductase; Region: TIGR00276 316275012918 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 316275012919 HMMPfam hit to PF08331, Domain of unknown function (DUF1730), score 1.7e-35 316275012920 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.00028 316275012921 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275012922 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 316275012923 catalytic site [active] 316275012924 putative active site [active] 316275012925 putative substrate binding site [chemical binding]; other site 316275012926 dimer interface [polypeptide binding]; other site 316275012927 HMMPfam hit to PF00929, Exonuclease, score 1.3e-37 316275012928 GTPase RsgA; Reviewed; Region: PRK12288 316275012929 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 316275012930 RNA binding site [nucleotide binding]; other site 316275012931 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 316275012932 GTPase/Zn-binding domain interface [polypeptide binding]; other site 316275012933 GTP/Mg2+ binding site [chemical binding]; other site 316275012934 G4 box; other site 316275012935 G5 box; other site 316275012936 G1 box; other site 316275012937 Switch I region; other site 316275012938 G2 box; other site 316275012939 G3 box; other site 316275012940 Switch II region; other site 316275012941 HMMPfam hit to PF03193, Protein of unknown function, DUF258, score 5.5e-143 316275012942 PS00017 ATP/GTP-binding site motif A (P-loop). 316275012943 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 316275012944 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 4e-88 316275012945 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275012946 EamA-like transporter family; Region: EamA; pfam00892 316275012947 EamA-like transporter family; Region: EamA; pfam00892 316275012949 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.9e-09 316275012950 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.5e-17 316275012951 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 316275012952 poxB regulator PoxA; Provisional; Region: PRK09350 316275012953 motif 1; other site 316275012954 dimer interface [polypeptide binding]; other site 316275012955 active site 316275012956 motif 2; other site 316275012957 motif 3; other site 316275012958 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 3.7e-78 316275012959 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275012960 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275012961 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 316275012962 L-aspartate oxidase; Provisional; Region: PRK06175 316275012963 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 316275012964 HMMPfam hit to PF00890, FAD binding domain, score 1.4e-152 316275012965 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidore, score 0.0004 316275012966 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 316275012967 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 3.1e-59 316275012968 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 316275012969 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316275012970 catalytic loop [active] 316275012971 iron binding site [ion binding]; other site 316275012972 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 0.0032 316275012973 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 316275012974 HMMPfam hit to PF00037, 4Fe-4S binding domain, score 0.0015 316275012975 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275012976 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 316275012977 D-subunit interface [polypeptide binding]; other site 316275012978 Iron-sulfur protein interface; other site 316275012979 proximal quinone binding site [chemical binding]; other site 316275012980 HMMPfam hit to PF02300, Fumarate reductase subunit C, score 1.2e-38 316275012982 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 316275012983 Iron-sulfur protein interface; other site 316275012984 proximal quinone binding site [chemical binding]; other site 316275012985 C-subunit interface; other site 316275012986 distal quinone binding site; other site 316275012987 HMMPfam hit to PF02313, Fumarate reductase subunit D, score 7.4e-38 316275012989 elongation factor P; Validated; Region: PRK00529 316275012990 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 316275012991 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 316275012992 RNA binding site [nucleotide binding]; other site 316275012993 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 316275012994 RNA binding site [nucleotide binding]; other site 316275012995 PS01275 Elongation factor P signature. 316275012996 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 5.5e-20 316275012997 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 2.5e-27 316275012998 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 316275012999 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275013000 FeS/SAM binding site; other site 316275013001 HMMPfam hit to PF04055, Radical SAM superfamily, score 2.6e-07 316275013002 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 316275013003 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 316275013004 active site 316275013005 ADP/pyrophosphate binding site [chemical binding]; other site 316275013006 dimerization interface [polypeptide binding]; other site 316275013007 allosteric effector site; other site 316275013008 fructose-1,6-bisphosphate binding site; other site 316275013009 HMMPfam hit to PF00365, Phosphofructokinase, score 2.5e-177 316275013010 PS00433 Phosphofructokinase signature. 316275013011 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 316275013012 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 316275013013 PS00307 Legume lectins beta-chain signature. 316275013014 HMMPfam hit to PF01545, Cation efflux family, score 2.2e-101 316275013016 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 316275013017 dimer interface [polypeptide binding]; other site 316275013018 HMMPfam hit to PF07813, LTXXQ motif, score 0.0031 316275013020 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 316275013021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275013022 active site 316275013023 phosphorylation site [posttranslational modification] 316275013024 intermolecular recognition site; other site 316275013025 dimerization interface [polypeptide binding]; other site 316275013026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275013027 DNA binding site [nucleotide binding] 316275013028 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-37 316275013029 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.3e-18 316275013030 two-component sensor protein; Provisional; Region: cpxA; PRK09470 316275013031 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275013032 dimerization interface [polypeptide binding]; other site 316275013033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275013034 dimer interface [polypeptide binding]; other site 316275013035 phosphorylation site [posttranslational modification] 316275013036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275013037 ATP binding site [chemical binding]; other site 316275013038 Mg2+ binding site [ion binding]; other site 316275013039 G-X-G motif; other site 316275013041 HMMPfam hit to PF00672, HAMP domain, score 1.6e-11 316275013042 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.8e-11 316275013043 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.2e-32 316275013044 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 316275013045 HMMPfam hit to PF00588, SpoU rRNA Methylase family, score 3.1e-41 316275013046 serine acetyltransferase; Provisional; Region: cysE; PRK11132 316275013047 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 316275013048 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 316275013049 trimer interface [polypeptide binding]; other site 316275013050 active site 316275013051 substrate binding site [chemical binding]; other site 316275013052 CoA binding site [chemical binding]; other site 316275013053 PS00101 Hexapeptide-repeat containing-transferases signature. 316275013054 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 3.9 316275013055 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 2.6 316275013056 HMMPfam hit to PF06426, Serine acetyltransferase, N-terminal, score 1.9e-60 316275013057 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 316275013058 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 316275013059 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 316275013060 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 6.3e-75 316275013061 PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 316275013062 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 1.1e-64 316275013063 HMMPfam hit to PF02558, Ketopantoate reductase PanE/ApbA, score 0.0049 316275013064 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 316275013065 SecA binding site; other site 316275013066 Preprotein binding site; other site 316275013067 HMMPfam hit to PF02556, Preprotein translocase subunit SecB, score 1.9e-69 316275013068 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316275013069 active site residue [active] 316275013070 HMMPfam hit to PF00581, Rhodanese-like domain, score 1.5e-12 316275013072 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 316275013073 Peptidase family M23; Region: Peptidase_M23; pfam01551 316275013074 HMMPfam hit to PF01551, Peptidase family M23, score 2.2e-41 316275013075 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 316275013076 HMMPfam hit to PF04186, FxsA cytoplasmic membrane protein, score 1.1e-51 316275013078 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 316275013079 Aspartase; Region: Aspartase; cd01357 316275013080 active sites [active] 316275013081 tetramer interface [polypeptide binding]; other site 316275013082 HMMPfam hit to PF00206, Lyase, score 3.6e-149 316275013083 PS00163 Fumarate lyases signature. 316275013084 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275013085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013086 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1e-119, 56.478% id in 494 aa. CDS contains a frameshift after codon 97 316275013087 Similar to Wolinella succinogenes Anaerobic C4-dicarboxylate transporter dcuA UniProt:O34245 (433 aa) fasta scores: E()=2.3e-100, 68.591% id in 433 aa. CDS contains a frameshift after codon 300. The sequence has been checked and is believed to be correct 316275013089 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 316275013090 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 316275013091 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 316275013092 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 316275013093 DsbD alpha interface [polypeptide binding]; other site 316275013094 catalytic residues [active] 316275013096 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmemb, score 1.8e-07 316275013097 HMMPfam hit to PF00085, Thioredoxin, score 0.0012 316275013098 PS00194 Thioredoxin family active site. 316275013099 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 316275013100 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 316275013101 active site 316275013102 trimer interface [polypeptide binding]; other site 316275013103 allosteric site; other site 316275013104 active site lid [active] 316275013105 hexamer (dimer of trimers) interface [polypeptide binding]; other site 316275013106 HMMPfam hit to PF01182, Glucosamine-6-phosphate isomerases/6-, score 3.6e-179 316275013107 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 316275013108 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 316275013109 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 316275013110 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 316275013111 active site 316275013112 P-loop; other site 316275013113 phosphorylation site [posttranslational modification] 316275013114 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275013115 active site 316275013116 phosphorylation site [posttranslational modification] 316275013117 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 9.7e-24 316275013119 HMMPfam hit to PF02302, PTS system, Lactose/Cellobiose specific II, score 1.7e-17 316275013120 HMMPfam hit to PF00359, Phosphoenolpyruvate-dependent sugar phosph, score 1.7e-61 316275013121 PS00372 PTS EIIA domains phosphorylation site signature 2. 316275013122 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 316275013123 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 316275013124 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 316275013125 HMMPfam hit to PF01232, Mannitol dehydrogenase Rossmann domain, score 1.2e-32 316275013126 HMMPfam hit to PF08125, Mannitol dehydrogenase C-terminal domai, score 2.6e-88 316275013127 PS00974 Mannitol dehydrogenases signature. 316275013128 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 316275013129 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 316275013130 HMMPfam hit to PF05068, Mannitol repressor, score 8.4e-83 316275013131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316275013132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275013134 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.9e-14 316275013135 Cyclin-dependent kinase inhibitor 3 (CDKN3); Region: CDKN3; pfam05706 316275013136 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 316275013137 PS00383 Tyrosine specific protein phosphatases active site. 316275013138 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 316275013139 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 316275013140 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 316275013141 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 2.5e-86 316275013142 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 316275013143 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 4e-72 316275013144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275013145 dimerization interface [polypeptide binding]; other site 316275013146 putative DNA binding site [nucleotide binding]; other site 316275013147 putative Zn2+ binding site [ion binding]; other site 316275013148 HMMPfam hit to PF01022, Bacterial regulatory protein, arsR family, score 1.6e-12 316275013149 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 316275013150 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 316275013151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275013152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275013153 metal binding site [ion binding]; metal-binding site 316275013154 active site 316275013155 I-site; other site 316275013156 HMMPfam hit to PF01590, GAF domain, score 0.00015 316275013157 HMMPfam hit to PF00990, GGDEF domain, score 2e-35 316275013158 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 316275013159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275013160 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 5e-06 316275013161 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 1.3e-09 316275013162 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 316275013163 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 316275013164 glutaminase active site [active] 316275013165 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 316275013166 dimer interface [polypeptide binding]; other site 316275013167 active site 316275013168 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 316275013169 dimer interface [polypeptide binding]; other site 316275013170 active site 316275013171 HMMPfam hit to PF01380, SIS domain, score 2.4e-26 316275013172 HMMPfam hit to PF01380, SIS domain, score 6e-43 316275013173 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 1.7e-52 316275013174 PS00443 Glutamine amidotransferases class-II active site. 316275013175 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 316275013176 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 316275013177 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 316275013178 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 3.2e-43 316275013179 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 4.8e-19 316275013180 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 0.0024 316275013181 HMMPfam hit to PF08279, HTH domain, score 4.8e-05 316275013182 HMMPfam hit to PF08280, M protein trans-acting positive regulator (M, score 0.00096 316275013183 Predicted helix-turn-helix motif with score 1371.000, SD 3.86 at aa 23-44, sequence ITVEELSELFDISEVTIRKDLT 316275013184 PS00894 Bacterial regulatory proteins, deoR family signature. 316275013185 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 316275013186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275013187 active site 316275013188 phosphorylation site [posttranslational modification] 316275013189 intermolecular recognition site; other site 316275013190 dimerization interface [polypeptide binding]; other site 316275013191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316275013192 DNA binding residues [nucleotide binding] 316275013193 dimerization interface [polypeptide binding]; other site 316275013194 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.2e-24 316275013195 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.1e-21 316275013196 PS00622 Bacterial regulatory proteins, luxR family signature. 316275013197 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 316275013198 HMMPfam hit to PF01914, MarC family integral membrane protein, score 3.1e-41 316275013200 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275013201 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275013202 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275013203 HMMPfam hit to PF01609, Transposase DDE domain, score 7.6e-28 316275013204 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 316275013206 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 316275013207 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 316275013208 Na binding site [ion binding]; other site 316275013210 HMMPfam hit to PF00474, Sodium:solute symporter family, score 6.5e-28 316275013211 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 316275013212 Na binding site [ion binding]; other site 316275013213 PAS fold; Region: PAS_7; pfam12860 316275013214 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275013215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275013216 dimer interface [polypeptide binding]; other site 316275013217 phosphorylation site [posttranslational modification] 316275013218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275013219 ATP binding site [chemical binding]; other site 316275013220 Mg2+ binding site [ion binding]; other site 316275013221 G-X-G motif; other site 316275013222 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316275013223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275013224 active site 316275013225 phosphorylation site [posttranslational modification] 316275013226 intermolecular recognition site; other site 316275013227 dimerization interface [polypeptide binding]; other site 316275013228 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.1e-16 316275013229 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 4.3e-33 316275013230 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 4.5e-13 316275013231 HMMPfam hit to PF08448, PAS fold, score 0.00088 316275013233 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 316275013235 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1.5e-10 316275013236 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 316275013237 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 316275013238 ligand binding site [chemical binding]; other site 316275013239 flexible hinge region; other site 316275013240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain. Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589 316275013241 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 316275013242 metal binding triad; other site 316275013243 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 4.3e-11 316275013244 HMMPfam hit to PF00571, CBS domain pair, score 1.3e-14 316275013245 HMMPfam hit to PF03445, nucleotidyltransferase DUF294, score 8.9e-41 316275013246 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 316275013247 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 316275013248 active site 316275013249 catalytic site [active] 316275013250 substrate binding site [chemical binding]; other site 316275013251 HMMPfam hit to PF00929, Exonuclease, score 4.4e-14 316275013252 PS00028 Zinc finger, C2H2 type, domain. 316275013253 acetyl-CoA synthetase; Provisional; Region: PRK00174 316275013254 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 316275013255 active site 316275013256 CoA binding site [chemical binding]; other site 316275013257 acyl-activating enzyme (AAE) consensus motif; other site 316275013258 AMP binding site [chemical binding]; other site 316275013259 acetate binding site [chemical binding]; other site 316275013260 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.8e-131 316275013261 PS00455 AMP-binding domain signature. 316275013262 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 316275013263 Dehydroquinase class II; Region: DHquinase_II; pfam01220 316275013264 active site 316275013265 trimer interface [polypeptide binding]; other site 316275013266 dimer interface [polypeptide binding]; other site 316275013267 HMMPfam hit to PF01220, Dehydroquinase class II, score 2.6e-87 316275013268 PS01029 Dehydroquinase class II signature. 316275013269 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 316275013270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 316275013271 carboxyltransferase (CT) interaction site; other site 316275013272 biotinylation site [posttranslational modification]; other site 316275013273 HMMPfam hit to PF00364, Biotin-requiring enzyme, score 8.1e-34 316275013274 PS00188 Biotin-requiring enzymes attachment site. 316275013275 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 316275013276 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 316275013277 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 316275013278 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 316275013279 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 3.1e-50 316275013280 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 7.5e-118 316275013281 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 316275013282 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 316275013283 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 1.8e-65 316275013284 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 316275013285 Methyltransferase domain; Region: Methyltransf_18; pfam12847 316275013286 HMMPfam hit to PF06325, Ribosomal protein L11 methyltransfera, score 1.1e-169 316275013287 HMMPfam hit to PF05175, Methyltransferase small domain, score 2.5e-05 316275013288 HMMPfam hit to PF08241, Methyltransferase domain, score 8.4e-06 316275013289 HMMPfam hit to PF08242, Methyltransferase domain, score 4.5e-10 316275013290 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 316275013291 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 316275013292 FMN binding site [chemical binding]; other site 316275013293 active site 316275013294 catalytic residues [active] 316275013295 substrate binding site [chemical binding]; other site 316275013296 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, score 0.055 316275013297 HMMPfam hit to PF01207, Dihydrouridine synthase (Dus), score 1.3e-144 316275013298 PS01136 Uncharacterized protein family UPF0034 signature. 316275013299 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 316275013300 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 316275013301 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis family, score 4.5e-15 316275013302 Predicted helix-turn-helix motif with score 1978.000, SD 5.92 at aa 72-93, sequence GNQTKAANMMGINRGTLRKKLK 316275013303 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 316275013304 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 316275013305 DNA binding residues [nucleotide binding] 316275013306 dimer interface [polypeptide binding]; other site 316275013307 metal binding site [ion binding]; metal-binding site 316275013308 HMMPfam hit to PF00376, MerR family regulatory protein, score 1.5e-10 316275013309 Predicted helix-turn-helix motif with score 1217.000, SD 3.33 at aa 2-23, sequence YLIGELAKHCNVTSDTLRFYEK 316275013310 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 316275013311 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 316275013312 purine monophosphate binding site [chemical binding]; other site 316275013313 dimer interface [polypeptide binding]; other site 316275013314 putative catalytic residues [active] 316275013315 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 316275013316 HMMPfam hit to PF02142, MGS-like domain, score 6.9e-60 316275013317 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, score 3.6e-196 316275013318 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 316275013319 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 316275013320 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 316275013321 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 316275013322 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, N d, score 8.9e-60 316275013323 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP, score 1.2e-128 316275013324 HMMPfam hit to PF02655, ATP-grasp domain, score 0.0014 316275013325 PS00184 Phosphoribosylglycinamide synthetase signature. 316275013326 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, C d, score 2.3e-49 316275013327 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275013328 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275013329 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275013330 HMMPfam hit to PF01609, Transposase DDE domain, score 7.6e-28 316275013331 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 316275013332 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 316275013333 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275013334 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 316275013335 IHF dimer interface [polypeptide binding]; other site 316275013336 IHF - DNA interface [nucleotide binding]; other site 316275013337 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 2.4e-52 316275013338 PS00045 Bacterial histone-like DNA-binding proteins signature. 316275013339 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 316275013340 Domain of unknown function DUF21; Region: DUF21; pfam01595 316275013341 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316275013342 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 3.9e-27 316275013344 HMMPfam hit to PF00571, CBS domain pair, score 1.9e-20 316275013345 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275013346 Protein of unknown function (DUF416); Region: DUF416; pfam04222 316275013347 HMMPfam hit to PF04222, Protein of unknown function, DUF, score 1e-127 316275013348 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 316275013349 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 316275013350 NAD binding site [chemical binding]; other site 316275013351 ligand binding site [chemical binding]; other site 316275013352 catalytic site [active] 316275013353 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrog, score 7.7e-38 316275013354 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 316275013355 putative metal binding site [ion binding]; other site 316275013356 HMMPfam hit to PF07049, Protein of unknown function (DUF1332), score 1e-46 316275013357 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 316275013358 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 316275013359 substrate binding site [chemical binding]; other site 316275013360 active site 316275013361 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 5.4e-196 316275013362 PS00907 Uroporphyrinogen decarboxylase signature 2. 316275013363 PS00906 Uroporphyrinogen decarboxylase signature 1. 316275013364 Similar to Escherichia coli NADH pyrophosphatase NudC UniProt:P32664 (257 aa) fasta scores: E()=6.5e-41, 46.063% id in 254 aa. CDS is disrupted by the insertion of an IS element after codon 108 316275013365 HMMPfam hit to PF00293, NUDIX domain, score 1.6e-24 316275013366 PS00893 mutT domain signature. 316275013367 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275013368 Putative transposase; Region: Y2_Tnp; pfam04986 316275013369 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 316275013370 HMMPfam hit to PF04353, Regulator of RNA polymerase sigma(70) subuni, score 1.4e-52 316275013371 HMMPfam hit to PF03783, Curli production assembly/transport componen, score 4.7e-49 316275013372 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082 316275013373 Curli assembly protein CsgE; Region: CsgE; pfam10627 316275013374 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 316275013375 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316275013376 DNA binding residues [nucleotide binding] 316275013377 dimerization interface [polypeptide binding]; other site 316275013378 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 5.7e-19 316275013379 PS00622 Bacterial regulatory proteins, luxR family signature. 316275013380 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275013381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275013382 Homeodomain-like domain; Region: HTH_23; cl17451 316275013383 Winged helix-turn helix; Region: HTH_29; pfam13551 316275013384 Homeodomain-like domain; Region: HTH_32; pfam13565 316275013385 CDS is truncated by the insertion of the downstream IS element and subsequent recombination events; Similar to Photorhabdus luminescens Transposase, IS982 family UniProt:Q7M7D4 (294 aa) fasta scores: E()=1.2e-53, 60.9% id in 207 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275013386 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275013387 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275013388 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275013389 HMMPfam hit to PF07012, Curlin associated repeat, score 0.0009 316275013390 HMMPfam hit to PF07012, Curlin associated repeat, score 0.00018 316275013391 HMMPfam hit to PF07012, Curlin associated repeat, score 3.4e-07 316275013392 HMMPfam hit to PF07012, Curlin associated repeat, score 0.12 316275013393 HMMPfam hit to PF07012, Curlin associated repeat, score 0.051 316275013394 HMMPfam hit to PF07012, Curlin associated repeat, score 1.1 316275013395 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 316275013396 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 316275013397 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 316275013398 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 316275013399 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 316275013400 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 316275013401 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 316275013402 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 316275013403 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 316275013404 DNA binding site [nucleotide binding] 316275013405 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 316275013406 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain, score 8.2e-105 316275013407 PS00012 Phosphopantetheine attachment site. 316275013408 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain, score 5.9e-32 316275013409 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain, score 4.5e-49 316275013410 HMMPfam hit to PF00623, RNA polymerase Rpb1, domain, score 2.4e-84 316275013411 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain, score 2.9e-158 316275013412 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 316275013413 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 316275013414 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 316275013415 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 316275013416 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 316275013417 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 316275013418 RPB3 interaction site [polypeptide binding]; other site 316275013419 RPB1 interaction site [polypeptide binding]; other site 316275013420 RPB11 interaction site [polypeptide binding]; other site 316275013421 RPB10 interaction site [polypeptide binding]; other site 316275013422 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain, score 8.4e-52 316275013423 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain, score 6.6e-178 316275013424 PS01166 RNA polymerases beta chain signature. 316275013425 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain, score 2.9e-42 316275013426 HMMPfam hit to PF04563, RNA polymerase beta subunit, score 9.5e-39 316275013427 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain, score 9.3e-07 316275013428 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 316275013429 core dimer interface [polypeptide binding]; other site 316275013430 peripheral dimer interface [polypeptide binding]; other site 316275013431 L10 interface [polypeptide binding]; other site 316275013432 L11 interface [polypeptide binding]; other site 316275013433 putative EF-Tu interaction site [polypeptide binding]; other site 316275013434 putative EF-G interaction site [polypeptide binding]; other site 316275013435 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 7.3e-36 316275013436 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 316275013437 23S rRNA interface [nucleotide binding]; other site 316275013438 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 316275013439 HMMPfam hit to PF00466, Ribosomal protein L10, score 1.7e-33 316275013440 Predicted helix-turn-helix motif with score 996.000, SD 2.58 at aa 39-60, sequence TSLRKQAREAGVYMRVVRNTLA 316275013441 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 316275013442 mRNA/rRNA interface [nucleotide binding]; other site 316275013443 PS01199 Ribosomal protein L1 signature. 316275013444 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 316275013445 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 316275013446 23S rRNA interface [nucleotide binding]; other site 316275013447 L7/L12 interface [polypeptide binding]; other site 316275013448 putative thiostrepton binding site; other site 316275013449 L25 interface [polypeptide binding]; other site 316275013450 PS00359 Ribosomal protein L11 signature. 316275013451 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 316275013452 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 316275013453 putative homodimer interface [polypeptide binding]; other site 316275013454 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 316275013455 heterodimer interface [polypeptide binding]; other site 316275013456 homodimer interface [polypeptide binding]; other site 316275013457 PS01014 Transcription termination factor nusG signature. 316275013458 HMMPfam hit to PF02357, Transcription termination factor nusG, score 1.5e-25 316275013459 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 316275013460 HMMPfam hit to PF00584, SecE/Sec61-gamma subunits of protein translo, score 3.1e-22 316275013462 PS01067 Protein secE/sec61-gamma signature. 316275013463 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 2.5e-60 316275013464 HMMPfam hit to PF03144, Elongation factor Tu domain, score 2.4e-24 316275013465 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.3e-97 316275013466 PS00301 GTP-binding elongation factors signature. 316275013467 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013468 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275013469 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275013470 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275013471 pantothenate kinase; Provisional; Region: PRK05439 316275013472 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 316275013473 ATP-binding site [chemical binding]; other site 316275013474 CoA-binding site [chemical binding]; other site 316275013475 Mg2+-binding site [ion binding]; other site 316275013476 HMMPfam hit to PF00485, Phosphoribulokinase / Uridine kinase family, score 2.6e-06 316275013477 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013478 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 316275013479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275013480 putative DNA binding site [nucleotide binding]; other site 316275013481 dimerization interface [polypeptide binding]; other site 316275013482 putative Zn2+ binding site [ion binding]; other site 316275013483 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 316275013484 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 316275013485 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 1.9e-20 316275013486 HMMPfam hit to PF08279, HTH domain, score 8.8e-11 316275013487 Predicted helix-turn-helix motif with score 1631.000, SD 4.74 at aa 20-41, sequence HSGEDLGDDIGVSRAAISKHIK 316275013488 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 316275013489 FAD binding domain; Region: FAD_binding_4; pfam01565 316275013490 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 316275013491 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine red, score 7.4e-46 316275013492 Predicted helix-turn-helix motif with score 1011.000, SD 2.63 at aa 195-216, sequence GPLADLSSVVGVTAESVFKAIC 316275013493 HMMPfam hit to PF01565, FAD binding domain, score 1.6e-06 316275013494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 316275013495 Coenzyme A binding pocket [chemical binding]; other site 316275013496 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 0.0018 316275013497 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 316275013498 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 316275013499 domain interface [polypeptide binding]; other site 316275013500 putative active site [active] 316275013501 catalytic site [active] 316275013502 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 316275013503 domain interface [polypeptide binding]; other site 316275013504 putative active site [active] 316275013505 catalytic site [active] 316275013506 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 5.9e-06 316275013507 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 9.8e-06 316275013508 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275013509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013510 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275013511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013512 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275013513 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275013514 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275013515 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 316275013517 HMMPfam hit to PF00076, RNA recognition motif. (a.k.a. RRM, RBD, or, score 1e-22 316275013518 glutamate racemase; Provisional; Region: PRK00865 316275013519 HMMPfam hit to PF01177, Asp/Glu/Hydantoin racemase, score 1.8e-74 316275013520 PS00924 Aspartate and glutamate racemases signature 2. 316275013521 PS00923 Aspartate and glutamate racemases signature 1. 316275013522 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 316275013523 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 316275013524 Ligand Binding Site [chemical binding]; other site 316275013525 HMMPfam hit to PF01902, ATP-binding region, score 1e-10 316275013526 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 316275013527 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 316275013528 N-terminal plug; other site 316275013529 ligand-binding site [chemical binding]; other site 316275013530 HMMPfam hit to PF00593, TonB dependent receptor, score 1.5e-21 316275013531 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 316275013532 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.3e-27 316275013533 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 316275013534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275013535 S-adenosylmethionine binding site [chemical binding]; other site 316275013536 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 1.6e-264 316275013537 PS01230 RNA methyltransferase trmA family signature 1. 316275013538 PS01231 RNA methyltransferase trmA family signature 2. 316275013539 hypothetical protein; Provisional; Region: PRK11056 316275013540 HMMPfam hit to PF07226, Protein of unknown function (DUF1422), score 7.2e-52 316275013542 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 316275013543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275013544 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 7.1e-10 316275013545 Predicted helix-turn-helix motif with score 1454.000, SD 4.14 at aa 61-82, sequence LSLREVTREAGIAPTSFYRHFK 316275013546 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 316275013547 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275013548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275013549 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 316275013550 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 7.2e-48 316275013551 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00057 316275013552 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 1.4e-25 316275013553 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 6.3e-39 316275013554 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 316275013555 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 316275013557 HMMPfam hit to PF01554, MatE, score 2.1e-29 316275013558 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 316275013559 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 316275013560 HMMPfam hit to PF02409, O-methyltransferase N-terminus, score 4.5e-17 316275013561 PS00190 Cytochrome c family heme-binding site signature. 316275013562 LexA repressor; Validated; Region: PRK00215 316275013563 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 316275013564 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 316275013565 Catalytic site [active] 316275013566 HMMPfam hit to PF00717, Peptidase S24-like, score 3.3e-20 316275013567 HMMPfam hit to PF01726, LexA DNA binding domain, score 3.1e-38 316275013568 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 316275013569 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 316275013570 putative acyl-acceptor binding pocket; other site 316275013571 HMMPfam hit to PF01553, Acyltransferase, score 7.2e-35 316275013572 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 316275013573 UbiA prenyltransferase family; Region: UbiA; pfam01040 316275013575 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 1.4e-67 316275013576 Chorismate lyase; Region: Chor_lyase; cl01230 316275013577 HMMPfam hit to PF04345, Chorismate lyase, score 9.7e-44 316275013578 flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697 316275013579 HMMPfam hit to PF03748, Flagellar basal body-associated protein FliL, score 1.5e-21 316275013581 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 316275013582 rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239 316275013583 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 316275013584 HMMPfam hit to PF01694, Rhomboid family, score 2.7e-34 316275013586 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 316275013587 active site residue [active] 316275013588 HMMPfam hit to PF00581, Rhodanese-like domain, score 9.4e-15 316275013589 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 316275013590 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316275013591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316275013592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316275013593 DNA binding residues [nucleotide binding] 316275013594 HMMPfam hit to PF04545, Sigma-70, region, score 2.2e-15 316275013595 PS00716 Sigma-70 factors family signature 2. 316275013596 Predicted helix-turn-helix motif with score 1646.000, SD 4.79 at aa 251-272, sequence TTLQELANTYSVSAERIRQLEK 316275013597 Predicted helix-turn-helix motif with score 1646.000, SD 4.79 at aa 152-173, sequence GEVEAVAKDLGVSPSEVREMES 316275013598 HMMPfam hit to PF04542, Sigma-70 region, score 5.2e-22 316275013599 PS00715 Sigma-70 factors family signature 1. 316275013600 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 316275013601 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 316275013602 HMMPfam hit to PF02687, Predicted permease, score 1.3e-23 316275013604 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 316275013605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275013606 Walker A/P-loop; other site 316275013607 ATP binding site [chemical binding]; other site 316275013608 Q-loop/lid; other site 316275013609 ABC transporter signature motif; other site 316275013610 Walker B; other site 316275013611 D-loop; other site 316275013612 H-loop/switch region; other site 316275013613 HMMPfam hit to PF00005, ABC transporter score 4.2e-64 316275013614 PS00211 ABC transporters family signature. 316275013615 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013616 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 316275013617 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 316275013618 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 316275013619 P loop; other site 316275013620 GTP binding site [chemical binding]; other site 316275013621 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 1.5e-122 316275013622 PS00300 SRP54-type proteins GTP-binding domain signature. 316275013623 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013624 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 1.1e-15 316275013625 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 316275013626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275013627 S-adenosylmethionine binding site [chemical binding]; other site 316275013628 HMMPfam hit to PF03602, Conserved hypothetical protein, score 9.5e-86 316275013629 PS00092 N-6 Adenine-specific DNA methylases signature. 316275013630 Predicted membrane protein [Function unknown]; Region: COG3776 316275013631 HMMPfam hit to PF06611, Protein of unknown function (DUF1145), score 2.3e-33 316275013633 Similar to Vibrio fischeri Multiple antibiotic resistance protein MarC UniProt:Q5E1Z5 (197 aa) fasta scores: E()=2.4e-61, 94.388% id in 196 aa. CDS contains a frameshift after codon 68. The sequence has been checked and is believed to be correct 316275013634 HMMPfam hit to PF01914, MarC family integral membrane protein, score 1.2e-57 316275013636 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275013637 probable metal-binding protein; Region: matur_matur; TIGR03853 316275013639 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 316275013641 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 316275013642 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 316275013643 ssDNA binding site; other site 316275013644 generic binding surface II; other site 316275013645 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275013646 ATP binding site [chemical binding]; other site 316275013647 putative Mg++ binding site [ion binding]; other site 316275013648 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275013649 nucleotide binding region [chemical binding]; other site 316275013650 ATP-binding site [chemical binding]; other site 316275013651 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 7.6e-07 316275013652 HMMPfam hit to PF00270, DEAD/DEAH box helicase, score 2.1e-34 316275013653 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013654 PS00435 Peroxidases proximal heme-ligand signature. 316275013655 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 9.4e-23 316275013656 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 316275013657 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 316275013658 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 316275013659 HMMPfam hit to PF01106, NifU-like domain, score 5.7e-07 316275013660 HMMPfam hit to PF01521, Iron-sulphur cluster biosynthesis, score 1.1e-33 316275013661 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 316275013662 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 316275013663 active site 316275013664 HMMPfam hit to PF00459, Inositol monophosphatase family, score 2.6e-58 316275013665 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 316275013666 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 316275013667 dimer interface [polypeptide binding]; other site 316275013668 ADP-ribose binding site [chemical binding]; other site 316275013669 active site 316275013670 nudix motif; other site 316275013671 metal binding site [ion binding]; metal-binding site 316275013672 HMMPfam hit to PF00293, NUDIX domain, score 9.3e-13 316275013673 PS00893 mutT domain signature. 316275013674 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 316275013675 HMMPfam hit to PF01203, Bacterial type II secretion system protein N, score 1.3e-62 316275013677 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 316275013678 HMMPfam hit to PF04612, General secretion pathway, M protein, score 4e-56 316275013680 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 316275013681 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 316275013682 GspL periplasmic domain; Region: GspL_C; pfam12693 316275013683 HMMPfam hit to PF05134, General secretion pathway protein L (GspL), score 1.1e-71 316275013684 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 316275013685 HMMPfam hit to PF03934, General secretion pathway protein K, score 1.8e-112 316275013687 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 316275013688 type II secretion system protein J; Region: gspJ; TIGR01711 316275013689 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 316275013690 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 1.5e-07 316275013692 PS00409 Prokaryotic N-terminal methylation site. 316275013693 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 316275013694 type II secretion system protein I; Region: gspI; TIGR01707 316275013695 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 316275013696 HMMPfam hit to PF02501, Bacterial type II secretion system protein I, score 2.8e-28 316275013698 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 3.9e-06 316275013699 PS00409 Prokaryotic N-terminal methylation site. 316275013701 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 316275013702 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 316275013703 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 316275013704 HMMPfam hit to PF08334, Bacterial type II secretion system protein G, score 3.8e-68 316275013705 PS00761 Signal peptidases I signature 3. 316275013707 HMMPfam hit to PF07963, Prokaryotic N-terminal methylation motif, score 5.2e-08 316275013708 PS00409 Prokaryotic N-terminal methylation site. 316275013709 type II secretion system protein F; Region: GspF; TIGR02120 316275013710 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316275013711 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316275013713 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 6.4e-23 316275013714 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 4.7e-25 316275013715 PS00874 Bacterial type II secretion system protein F signature. 316275013716 type II secretion system protein E; Region: type_II_gspE; TIGR02533 316275013717 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 316275013718 Walker A motif; other site 316275013719 ATP binding site [chemical binding]; other site 316275013720 Walker B motif; other site 316275013721 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 9.3e-146 316275013722 PS00662 Bacterial type II secretion system protein E signature. 316275013723 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013724 type II secretion system protein D; Region: type_II_gspD; TIGR02517 316275013725 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316275013726 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316275013727 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 316275013728 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 316275013729 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 1.6e-92 316275013730 PS00875 Bacterial type II secretion system protein D signature. 316275013731 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 7.3e-14 316275013732 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.5e-11 316275013733 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2e-10 316275013734 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 316275013735 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 316275013736 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 316275013738 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 316275013739 RNA binding surface [nucleotide binding]; other site 316275013740 HMMPfam hit to PF01479, S4 domain, score 5.1e-13 316275013741 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 316275013742 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 316275013743 dimerization interface [polypeptide binding]; other site 316275013744 domain crossover interface; other site 316275013745 redox-dependent activation switch; other site 316275013746 HMMPfam hit to PF01430, Hsp33 protein, score 3.1e-128 316275013747 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 316275013748 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 316275013749 active site 316275013750 substrate-binding site [chemical binding]; other site 316275013751 metal-binding site [ion binding] 316275013752 ATP binding site [chemical binding]; other site 316275013753 HMMPfam hit to PF01293, Phosphoenolpyruvate carboxykinase, score 0 316275013754 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013755 PS00532 Phosphoenolpyruvate carboxykinase (ATP) signature. 316275013756 AsmA family; Region: AsmA; pfam05170 316275013757 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 316275013758 HMMPfam hit to PF05170, AsmA family, score 1.1e-58 316275013760 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 316275013761 EAL domain; Region: EAL; pfam00563 316275013762 HMMPfam hit to PF00563, EAL domain, score 5.6e-06 316275013763 lysophospholipase L2; Provisional; Region: PRK10749 316275013764 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316275013765 HMMPfam hit to PF00561, alpha/beta hydrolase fold, score 1.7e-19 316275013766 putative hydrolase; Provisional; Region: PRK10976 316275013767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275013768 active site 316275013769 motif I; other site 316275013770 motif II; other site 316275013771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275013772 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 6.1e-07 316275013773 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.8e-06 316275013774 PS01228 Hypothetical cof family signature 1. 316275013775 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 4e-88 316275013776 PS01229 Hypothetical cof family signature 2. 316275013777 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=2.6e-120, 56.680% id in 494 aa. CDS contains a frameshift after codon 97 316275013778 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275013779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 316275013781 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316275013782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275013783 Coenzyme A binding pocket [chemical binding]; other site 316275013784 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 316275013786 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 7.7e-16 316275013787 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 316275013788 putative active site [active] 316275013789 dimerization interface [polypeptide binding]; other site 316275013790 putative tRNAtyr binding site [nucleotide binding]; other site 316275013791 HMMPfam hit to PF02580, D-Tyr-tRNA(Tyr) deacylase, score 5.8e-54 316275013792 hypothetical protein; Reviewed; Region: PRK01637 316275013793 HMMPfam hit to PF03631, Ribonuclease BN-like family, score 1.4e-76 316275013795 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 316275013796 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 316275013797 G1 box; other site 316275013798 putative GEF interaction site [polypeptide binding]; other site 316275013799 GTP/Mg2+ binding site [chemical binding]; other site 316275013800 Switch I region; other site 316275013801 G2 box; other site 316275013802 G3 box; other site 316275013803 Switch II region; other site 316275013804 G4 box; other site 316275013805 G5 box; other site 316275013806 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 316275013807 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 316275013808 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 9.6e-24 316275013809 HMMPfam hit to PF03144, Elongation factor Tu domain, score 1.4e-11 316275013810 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 4.2e-69 316275013811 PS00301 GTP-binding elongation factors signature. 316275013812 PS00017 ATP/GTP-binding site motif A (P-loop). 316275013813 glutamine synthetase; Provisional; Region: glnA; PRK09469 316275013814 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 316275013815 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 316275013816 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp domain, score 2.2e-46 316275013817 PS00180 Glutamine synthetase signature 1. 316275013818 HMMPfam hit to PF00120, Glutamine synthetase, catalytic domain, score 5.2e-173 316275013819 PS00181 Glutamine synthetase ATP-binding region signature. 316275013820 PS00182 Glutamine synthetase class-I adenylation site. 316275013821 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275013822 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013823 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275013824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013825 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275013826 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275013827 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275013828 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 316275013829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275013830 putative DNA binding site [nucleotide binding]; other site 316275013831 putative Zn2+ binding site [ion binding]; other site 316275013832 AsnC family; Region: AsnC_trans_reg; pfam01037 316275013833 HMMPfam hit to PF01037, AsnC family, score 3.7e-19 316275013834 Predicted helix-turn-helix motif with score 1981.000, SD 5.93 at aa 24-45, sequence TPYAELAKRFNVSPATIHVRIE 316275013835 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 316275013836 HMMPfam hit to PF04445, Protein of unknown function (DUF548), score 8.5e-161 316275013837 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316275013838 Ligand Binding Site [chemical binding]; other site 316275013839 HMMPfam hit to PF00582, Universal stress protein family, score 4.1e-16 316275013840 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 316275013841 Ferritin-like domain; Region: Ferritin; pfam00210 316275013842 ferroxidase diiron center [ion binding]; other site 316275013843 HMMPfam hit to PF00210, Ferritin-like domain, score 2.5e-48 316275013844 universal stress protein UspB; Provisional; Region: PRK04960 316275013846 HI0933-like protein; Region: HI0933_like; pfam03486 316275013847 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275013848 HMMPfam hit to PF03486, HI0933-like protein, score 4e-232 316275013849 HMMPfam hit to PF00890, FAD binding domain, score 0.0023 316275013850 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 0.00011 316275013851 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 2.8e-05 316275013852 HMMPfam hit to PF08495, Domain of unknown function (DUF1745), score 9.4e-43 316275013853 HMMPfam hit to PF00563, EAL domain, score 3.2e-48 316275013854 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275013855 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013856 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275013857 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013858 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275013859 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275013860 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275013861 DTW domain; Region: DTW; cl01221 316275013862 HMMPfam hit to PF03942, DTW domain, score 1.6e-38 316275013863 Predicted membrane protein [Function unknown]; Region: COG3650 316275013864 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275013865 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 316275013866 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 316275013867 active site 316275013868 intersubunit interface [polypeptide binding]; other site 316275013869 catalytic residue [active] 316275013870 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 2.7e-91 316275013871 PS00159 KDPG and KHG aldolases active site. 316275013872 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 316275013873 Similar to Vibrio fischeri Sensory box/GGDEF family protein UniProt:Q5E8R0 (845 aa) fasta scores: E()=1.2e-17, 71.429% id in 77 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275013874 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=5.3e-119, 56.680% id in 494 aa. CDS contains a frameshift after codon 97 316275013875 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275013876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275013877 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 316275013878 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 316275013879 putative dimer interface [polypeptide binding]; other site 316275013880 HMMPfam hit to PF00011, Hsp20/alpha crystallin family, score 5.5e-19 316275013881 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275013882 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275013883 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275013884 HMMPfam hit to PF01609, Transposase DDE domain, score 7.6e-28 316275013885 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 316275013886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275013887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275013888 homodimer interface [polypeptide binding]; other site 316275013889 catalytic residue [active] 316275013890 HMMPfam hit to PF00155, Aminotransferase class I and II, score 7.4e-09 316275013891 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 316275013892 dimer interface [polypeptide binding]; other site 316275013893 motif 1; other site 316275013894 active site 316275013895 motif 2; other site 316275013896 motif 3; other site 316275013897 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 3.9e-239 316275013898 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275013899 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 316275013900 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 316275013901 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 0 316275013902 HMMPfam hit to PF05746, DALR anticodon binding domain, score 3.3e-05 316275013903 alpha-amylase; Reviewed; Region: malS; PRK09505 316275013904 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 316275013905 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 316275013906 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 2.4e-10 316275013908 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 316275013909 CPxP motif; other site 316275013910 HMMPfam hit to PF01206, SirA-like protein, score 1.2e-30 316275013911 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275013912 Putative transposase; Region: Y2_Tnp; pfam04986 316275013914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275013915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275013916 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 316275013917 substrate binding pocket [chemical binding]; other site 316275013918 dimerization interface [polypeptide binding]; other site 316275013919 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.5e-18 316275013920 Predicted helix-turn-helix motif with score 1499.000, SD 4.29 at aa 24-45, sequence NSVSQAAIRLNLSQSAMSRVLG 316275013921 PS00044 Bacterial regulatory proteins, lysR family signature. 316275013922 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.6e-16 316275013923 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 316275013924 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 316275013925 NADP binding site [chemical binding]; other site 316275013926 dimer interface [polypeptide binding]; other site 316275013927 HMMPfam hit to PF00107, Zinc-binding dehydrogenase, score 1.3e-08 316275013928 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 3.9e-08 316275013929 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 316275013930 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 316275013931 dimer interface [polypeptide binding]; other site 316275013932 active site 316275013933 HMMPfam hit to PF02803, Thiolase, C-terminal domain, score 5.4e-80 316275013934 PS00099 Thiolases active site. 316275013935 PS00737 Thiolases signature 2. 316275013936 HMMPfam hit to PF00108, Thiolase, N-terminal domain, score 6.5e-140 316275013937 PS00098 Thiolases acyl-enzyme intermediate signature. 316275013938 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 316275013939 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 316275013940 substrate binding site [chemical binding]; other site 316275013941 oxyanion hole (OAH) forming residues; other site 316275013942 trimer interface [polypeptide binding]; other site 316275013943 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 316275013944 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316275013945 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 316275013946 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 0.0001 316275013947 HMMPfam hit to PF00725, 3-hydroxyacyl-CoA dehydrogenase, C-terminal, score 9.2e-34 316275013948 PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 316275013949 HMMPfam hit to PF02737, 3-hydroxyacyl-CoA dehydrogenase, NAD binding, score 2.4e-86 316275013950 PS00659 Glycosyl hydrolases family 5 signature. 316275013951 HMMPfam hit to PF00378, Enoyl-CoA hydratase/isomerase family, score 7.8e-70 316275013952 PS00166 Enoyl-CoA hydratase/isomerase signature. 316275013953 hypothetical protein; Provisional; Region: PRK11568 316275013954 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 316275013955 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 316275013956 HMMPfam hit to PF01205, Uncharacterized protein family UPF0029, score 5.4e-54 316275013957 Cation transport protein; Region: TrkH; cl17365 316275013958 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 316275013960 HMMPfam hit to PF02386, Cation transport protein, score 3.1e-94 316275013961 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 316275013962 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 316275013963 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 316275013964 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316275013965 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 316275013966 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 6.8e-22 316275013967 PS00143 Insulinase family, zinc-binding region signature. 316275013968 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 7.8e-12 316275013969 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 4.8e-14 316275013970 camphor resistance protein CrcB; Provisional; Region: PRK14200 316275013972 HMMPfam hit to PF02537, CrcB-like protein, score 6.2e-32 316275013973 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316275013974 Ligand Binding Site [chemical binding]; other site 316275013975 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 316275013976 ThiC-associated domain; Region: ThiC-associated; pfam13667 316275013977 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 316275013978 HMMPfam hit to PF01964, ThiC family, score 0 316275013979 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 316275013980 thiamine phosphate binding site [chemical binding]; other site 316275013981 active site 316275013982 pyrophosphate binding site [ion binding]; other site 316275013983 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 2.8e-62 316275013984 PS00012 Phosphopantetheine attachment site. 316275013985 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 316275013986 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 316275013987 ATP binding site [chemical binding]; other site 316275013988 substrate interface [chemical binding]; other site 316275013989 HMMPfam hit to PF00899, ThiF family, score 3.8e-60 316275013990 HMMPfam hit to PF05237, MoeZ/MoeB domain, score 1.6e-22 316275013991 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 316275013992 thiS-thiF/thiG interaction site; other site 316275013993 HMMPfam hit to PF02597, ThiS family, score 8.5e-09 316275013994 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 316275013995 ThiS interaction site; other site 316275013996 putative active site [active] 316275013997 tetramer interface [polypeptide binding]; other site 316275013998 HMMPfam hit to PF05690, Thiazole biosynthesis protein ThiG, score 8.9e-163 316275013999 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 316275014000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275014001 FeS/SAM binding site; other site 316275014002 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 316275014003 HMMPfam hit to PF04055, Radical SAM superfamily, score 1.2e-08 316275014004 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 5.7e-40 316275014005 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 316275014006 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 316275014007 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 316275014008 active site 316275014009 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 316275014010 HMMPfam hit to PF00728, Glycosyl hydrolase family 20, catalyt, score 4e-121 316275014011 HMMPfam hit to PF02838, Glycosyl hydrolase family 20, domain, score 1.3e-09 316275014012 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 316275014013 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 316275014014 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 316275014015 active site 316275014016 HMMPfam hit to PF00557, metallopeptidase family M24, score 7.3e-10 316275014017 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 316275014018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275014019 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 316275014020 substrate binding pocket [chemical binding]; other site 316275014021 dimerization interface [polypeptide binding]; other site 316275014022 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.1e-15 316275014023 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 9.1e-20 316275014024 PS00044 Bacterial regulatory proteins, lysR family signature. 316275014025 Predicted helix-turn-helix motif with score 1425.000, SD 4.04 at aa 24-45, sequence KSVTRASQRLCLSQSAVSKNLA 316275014026 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 316275014027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275014028 putative substrate translocation pore; other site 316275014030 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 8.9e-45 316275014031 PS00216 Sugar transport proteins signature 1. 316275014032 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275014033 EamA-like transporter family; Region: EamA; pfam00892 316275014034 EamA-like transporter family; Region: EamA; pfam00892 316275014036 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.8e-12 316275014037 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.8e-14 316275014038 RmuC family; Region: RmuC; pfam02646 316275014040 HMMPfam hit to PF02646, RmuC family, score 1.3e-145 316275014041 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 316275014042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275014043 S-adenosylmethionine binding site [chemical binding]; other site 316275014044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 316275014045 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 4.7e-156 316275014046 PS01183 ubiE/COQ5 methyltransferase family signature 1. 316275014047 HMMPfam hit to PF08241, Methyltransferase domain, score 2.2e-27 316275014048 HMMPfam hit to PF08242, Methyltransferase domain, score 1.9e-12 316275014049 PS01184 ubiE/COQ5 methyltransferase family signature 2. 316275014050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 316275014051 SCP-2 sterol transfer family; Region: SCP2; pfam02036 316275014052 HMMPfam hit to PF06843, Protein of unknown function (DUF1243), score 8.4e-88 316275014053 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 316275014054 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 316275014055 HMMPfam hit to PF03109, ABC1 family, score 7.4e-52 316275014057 twin arginine translocase protein A; Provisional; Region: tatA; PRK04598 316275014058 HMMPfam hit to PF02416, mttA/Hcf106 family, score 5.6e-13 316275014060 sec-independent translocase; Provisional; Region: PRK01770 316275014061 HMMPfam hit to PF02416, mttA/Hcf106 family, score 0.00018 316275014063 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 316275014064 HMMPfam hit to PF00902, Sec-independent protein translocase protein, score 5.5e-96 316275014066 PS01218 Uncharacterized protein family UPF0032 signature. 316275014067 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275014068 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275014069 HMMPfam hit to PF01609, Transposase DDE domain, score 9.3e-30 316275014070 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 316275014071 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 316275014072 active site 316275014073 HMMPfam hit to PF01026, TatD related DNase, score 3e-95 316275014074 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 316275014075 dimer interface [polypeptide binding]; other site 316275014076 allosteric magnesium binding site [ion binding]; other site 316275014077 active site 316275014078 aspartate-rich active site metal binding site; other site 316275014079 Schiff base residues; other site 316275014080 HMMPfam hit to PF00490, Delta-aminolevulinic acid dehydratase, score 1.5e-196 316275014081 PS00169 Delta-aminolevulinic acid dehydratase active site. 316275014082 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014084 HMMPfam hit to PF05717, IS66 Orf2 like protein, score 5.1e-32 316275014085 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.1e-108, 55.578% id in 493 aa. CDS contains a frameshift after codon 73 316275014086 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 316275014087 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275014088 Transposase [DNA replication, recombination, and repair]; Region: COG5433 316275014089 Transposase [DNA replication, recombination, and repair]; Region: COG5433 316275014090 HMMPfam hit to PF01609, Transposase DDE domain, score 8.2e-26 316275014091 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 316275014092 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 316275014093 putative trimer interface [polypeptide binding]; other site 316275014094 putative CoA binding site [chemical binding]; other site 316275014095 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 11 316275014096 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 45 316275014097 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 10 316275014098 PS00101 Hexapeptide-repeat containing-transferases signature. 316275014099 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 14 316275014100 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 316275014101 NeuB family; Region: NeuB; pfam03102 316275014102 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 316275014103 NeuB binding interface [polypeptide binding]; other site 316275014104 putative substrate binding site [chemical binding]; other site 316275014105 HMMPfam hit to PF03102, NeuB family, score 6e-123 316275014106 HMMPfam hit to PF01354, Antifreeze-like domain, score 1.7e-22 316275014107 PS00018 EF-hand calcium-binding domain. 316275014108 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 316275014109 ligand binding site; other site 316275014110 tetramer interface; other site 316275014111 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 316275014112 active site 316275014113 catalytic triad [active] 316275014114 oxyanion hole [active] 316275014115 HMMPfam hit to PF02348, Cytidylyltransferase, score 7.9e-53 316275014116 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 316275014117 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 316275014118 active site 316275014119 homodimer interface [polypeptide binding]; other site 316275014120 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 8.9e-102 316275014121 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316275014122 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 316275014123 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 1.2e-10 316275014125 PS00012 Phosphopantetheine attachment site. 316275014126 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 316275014127 HMMPfam hit to PF05855, Lipooligosaccharide sialyltransferase (LST), score 5.1e-24 316275014128 Similar to Vibrio cholerae rfbQRSO155-1 UniProt:O51837 (377 aa) fasta scores: E()=2e-48, 37.534% id in 365 aa. CDS contains a frameshift after codon 210 316275014129 HMMPfam hit to PF01609, Transposase DDE domain, score 0.002 316275014130 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 316275014131 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 316275014132 NAD binding site [chemical binding]; other site 316275014133 substrate binding site [chemical binding]; other site 316275014134 homodimer interface [polypeptide binding]; other site 316275014135 active site 316275014136 HMMPfam hit to PF04321, RmlD substrate binding domain, score 2.2e-05 316275014137 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 7e-05 316275014138 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 8.4e-96 316275014139 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 3.9e-06 316275014140 HMMPfam hit to PF07993, Male sterility protein, score 3e-06 316275014141 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 316275014142 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 316275014143 substrate binding site; other site 316275014144 tetramer interface; other site 316275014145 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.2e-113 316275014146 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 316275014147 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 316275014148 NADP binding site [chemical binding]; other site 316275014149 active site 316275014150 putative substrate binding site [chemical binding]; other site 316275014151 HMMPfam hit to PF04321, RmlD substrate binding domain, score 1.6e-139 316275014152 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 8.9e-18 316275014153 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 1.2e-05 316275014154 HMMPfam hit to PF07993, Male sterility protein, score 5.5e-05 316275014155 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 316275014156 HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase, score 5.1e-105 316275014157 Similar to N-terminal part of Bacteroides thetaiotaomicron Hypothetical protein UniProt:Q8ABS0 (513 aa) fasta scores: E()=1.3e-13, 52.941% id in 102 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014159 Similar to Escherichia coli transposase yncI UniProt:P76119 (374 aa) fasta scores: E()=3.4e-58, 39.9% id in 383 aa. CDS contains a frameshift after codon 208 316275014160 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 316275014161 active site 316275014162 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.4e-29 316275014164 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 316275014165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316275014166 active site 316275014167 HMMPfam hit to PF00535, Glycosyl transferase family, score 0.00059 316275014169 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316275014170 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 316275014171 Probable Catalytic site; other site 316275014172 HMMPfam hit to PF00535, Glycosyl transferase family, score 2e-33 316275014173 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 316275014174 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 316275014175 trimer interface [polypeptide binding]; other site 316275014176 active site 316275014177 substrate binding site [chemical binding]; other site 316275014178 CoA binding site [chemical binding]; other site 316275014179 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 12 316275014180 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 3.7 316275014181 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.4 316275014182 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 3.5 316275014183 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316275014184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275014185 NAD(P) binding site [chemical binding]; other site 316275014186 active site 316275014187 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 2.7e-35 316275014188 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 4.3e-06 316275014189 HMMPfam hit to PF07993, Male sterility protein, score 0.00027 316275014190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275014191 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316275014192 NAD(P) binding site [chemical binding]; other site 316275014193 active site 316275014194 HMMPfam hit to PF04321, RmlD substrate binding domain, score 7.3e-05 316275014195 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 6.4e-24 316275014196 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 1.5e-10 316275014197 HMMPfam hit to PF07993, Male sterility protein, score 2.3e-08 316275014198 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014199 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 316275014200 HMMPfam hit to PF02397, Bacterial sugar transferase, score 1.6e-21 316275014202 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 316275014203 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316275014204 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 316275014205 NAD(P) binding site [chemical binding]; other site 316275014206 homodimer interface [polypeptide binding]; other site 316275014207 substrate binding site [chemical binding]; other site 316275014208 active site 316275014210 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 2e-202 316275014211 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 3.8e-06 316275014212 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 0.004 316275014213 Similar to Shewanella putrefaciens (strain CN-32/ATCC BAA-453) issod8, transposase. UniProt:A4Y9G9 (EMBL:CP000681) (206 aa) fasta scores: E()=1.9e-40, 67.089% id in 158 aa. CDS is truncated by the insertion of the upstream IS alement 316275014214 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014215 Putative transposase; Region: Y2_Tnp; pfam04986 316275014216 Similar to Shewanella oneidensis Methyl-accepting chemotaxis protein UniProt:Q8EGZ8 (543 aa) fasta scores: E()=2.7e-24, 35.987% id in 314 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014217 HMMPfam hit to PF00672, HAMP domain, score 0.0009 316275014219 Similar to Photobacterium profundum Hypothetical transposase, IS630 family UniProt:Q6LH76 (345 aa) fasta scores: E()=6.9e-79, 61.877% id in 341 aa. CDS contains a frameshift and two nonsense mutations 316275014220 Predicted helix-turn-helix motif with score 1238.000, SD 3.40 at aa 40-61, sequence WKVSMIAQALRIHKSTISLHIN 316275014221 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275014222 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014223 Putative transposase; Region: Y2_Tnp; pfam04986 316275014225 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 316275014226 HMMPfam hit to PF01755, Glycosyltransferase family 25 (LPS bi, score 3.6e-12 316275014227 Similar to Escherichia coli transposase yncI UniProt:P76119 (374 aa) fasta scores: E()=1.1e-58, 39.9% id in 383 aa. CDS contains a frameshift after codon 207 316275014228 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 316275014229 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 316275014230 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 316275014231 active site 316275014232 NTP binding site [chemical binding]; other site 316275014233 metal binding triad [ion binding]; metal-binding site 316275014234 antibiotic binding site [chemical binding]; other site 316275014235 Protein of unknown function DUF86; Region: DUF86; pfam01934 316275014236 HMMPfam hit to PF01934, Protein of unknown function DUF86, score 4e-12 316275014237 putative transposase; Provisional; Region: PRK09857 316275014238 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 316275014239 HMMPfam hit to PF04754, transposase, YhgA-like, score 5.5e-144 316275014240 COMPASS (Complex proteins associated with Set1p) component shg1; Region: COMPASS-Shg1; pfam05205 316275014241 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 316275014242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275014243 putative Mg++ binding site [ion binding]; other site 316275014244 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275014245 nucleotide binding region [chemical binding]; other site 316275014246 ATP-binding site [chemical binding]; other site 316275014247 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 4.8e-60 316275014248 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.2e-28 316275014249 HMMPfam hit to PF02272, DHHA1 domain, score 0.0013 316275014250 UDP-glucose 4-epimerase; Region: PLN02240 316275014251 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 316275014252 NAD binding site [chemical binding]; other site 316275014253 homodimer interface [polypeptide binding]; other site 316275014254 active site 316275014255 substrate binding site [chemical binding]; other site 316275014256 HMMPfam hit to PF04321, RmlD substrate binding domain, score 0.00078 316275014257 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase f, score 4.2e-71 316275014258 HMMPfam hit to PF02719, Polysaccharide biosynthesis protein, score 3.5e-05 316275014259 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/i, score 3.8e-08 316275014260 HMMPfam hit to PF07993, Male sterility protein, score 0.00025 316275014261 phosphoglyceromutase; Provisional; Region: PRK05434 316275014262 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 316275014263 HMMPfam hit to PF01676, Metalloenzyme superfamily, score 4.2e-50 316275014264 HMMPfam hit to PF06415, BPG-independent PGAM N-terminus (iPGM_N, score 4.2e-241 316275014265 Haemolysin XhlA; Region: XhlA; pfam10779 316275014268 HMMPfam hit to PF01554, MatE, score 7.5e-23 316275014269 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=8.5e-115, 55.668% id in 494 aa. CDS contains a frameshift after codon 219 316275014270 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014272 HMMPfam hit to PF01554, MatE, score 1e-35 316275014273 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014274 Putative transposase; Region: Y2_Tnp; pfam04986 316275014275 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 316275014276 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 316275014277 Substrate binding site; other site 316275014278 Mg++ binding site; other site 316275014279 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 316275014280 active site 316275014281 substrate binding site [chemical binding]; other site 316275014282 CoA binding site [chemical binding]; other site 316275014283 PS00101 Hexapeptide-repeat containing-transferases signature. 316275014284 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.19 316275014285 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 10 316275014286 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 12 316275014287 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 38 316275014288 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.17 316275014289 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (th, score 0.0061 316275014290 HMMPfam hit to PF00483, Nucleotidyl transferase, score 1.2e-06 316275014291 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 316275014292 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 316275014293 gamma subunit interface [polypeptide binding]; other site 316275014294 epsilon subunit interface [polypeptide binding]; other site 316275014295 LBP interface [polypeptide binding]; other site 316275014296 HMMPfam hit to PF00401, ATP synthase, Delta/Epsilon chain, long, score 1.8e-06 316275014297 HMMPfam hit to PF02823, ATP synthase, Delta/Epsilon chain, beta, score 1e-33 316275014298 PS00430 TonB-dependent receptor proteins signature 1. 316275014299 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 316275014300 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316275014301 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 316275014302 alpha subunit interaction interface [polypeptide binding]; other site 316275014303 Walker A motif; other site 316275014304 ATP binding site [chemical binding]; other site 316275014305 Walker B motif; other site 316275014306 inhibitor binding site; inhibition site 316275014307 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316275014308 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 4.6e-41 316275014309 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 1.7e-92 316275014310 PS00152 ATP synthase alpha and beta subunits signature. 316275014311 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014312 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 6.1e-25 316275014313 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 316275014314 core domain interface [polypeptide binding]; other site 316275014315 delta subunit interface [polypeptide binding]; other site 316275014316 epsilon subunit interface [polypeptide binding]; other site 316275014317 HMMPfam hit to PF00231, ATP synthase, score 1.6e-156 316275014318 PS00153 ATP synthase gamma subunit signature. 316275014319 PS00041 Bacterial regulatory proteins, araC family signature. 316275014320 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 316275014321 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 316275014322 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 316275014323 beta subunit interaction interface [polypeptide binding]; other site 316275014324 Walker A motif; other site 316275014325 ATP binding site [chemical binding]; other site 316275014326 Walker B motif; other site 316275014327 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 316275014328 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 4.5e-25 316275014329 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 6.5e-113 316275014330 PS00152 ATP synthase alpha and beta subunits signature. 316275014331 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014332 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2.5e-17 316275014333 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 316275014334 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 316275014335 HMMPfam hit to PF00213, ATP synthase delta (OSCP) subunit, score 1.5e-59 316275014336 PS00389 ATP synthase delta (OSCP) subunit signature. 316275014337 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 316275014338 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 316275014339 HMMPfam hit to PF00430, ATP synthase B/B' CF(0), score 4.4e-39 316275014341 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 316275014342 HMMPfam hit to PF00137, ATP synthase subunit C, score 6.4e-27 316275014344 PS00605 ATP synthase c subunit signature. 316275014345 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 316275014346 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 316275014347 HMMPfam hit to PF00119, ATP synthase A chain, score 4.8e-97 316275014349 PS00449 ATP synthase a subunit signature. 316275014350 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 316275014351 HMMPfam hit to PF03899, ATP synthase I chain, score 6.4e-63 316275014353 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 316275014354 ParB-like nuclease domain; Region: ParBc; pfam02195 316275014355 Predicted helix-turn-helix motif with score 1458.000, SD 4.15 at aa 154-175, sequence LTHQQISDVIGKSRTTVTNLLR 316275014356 HMMPfam hit to PF02195, ParB-like nuclease domain, score 6.2e-35 316275014357 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316275014358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275014359 P-loop; other site 316275014360 Magnesium ion binding site [ion binding]; other site 316275014361 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275014362 Magnesium ion binding site [ion binding]; other site 316275014363 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 4.2e-56 316275014364 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 316275014365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275014366 S-adenosylmethionine binding site [chemical binding]; other site 316275014367 HMMPfam hit to PF02527, Glucose inhibited division protein, score 5e-89 316275014368 PS00430 TonB-dependent receptor proteins signature 1. 316275014369 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 316275014370 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 316275014371 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 316275014372 Predicted helix-turn-helix motif with score 999.000, SD 2.59 at aa 596-617, sequence ESIGIASRISGITPAAISILLV 316275014373 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 2.6e-281 316275014374 PS01281 Glucose inhibited division protein A family signature 2. 316275014375 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.00084 316275014376 HMMPfam hit to PF00890, FAD binding domain, score 0.0024 316275014377 PS01280 Glucose inhibited division protein A family signature 1. 316275014378 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275014379 Protein of unknown function (DUF3346); Region: DUF3346; pfam11826 316275014380 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 316275014381 homotrimer interaction site [polypeptide binding]; other site 316275014382 putative active site [active] 316275014383 HMMPfam hit to PF01042, Endoribonuclease L-PSP,score 1.3e-23 316275014384 PS01094 Uncharacterized protein family UPF0076 signature. 316275014385 Similar to Aeromonas sobria Proline iminopeptidase UniProt:P46547 (424 aa) fasta scores: E()=4.6e-97, 55.140% id in 428 aa. CDS contains a frameshift after codon 48. The sequence has been checked and is believed to be correct 316275014386 HMMPfam hit to PF00561, alpha/beta hydrolase fold,score 3.7e-10 316275014387 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E1M3 (513 aa) fasta scores: E()=2.7e-140,70.378% id in 503 aa. CDS contains a nonsense mutation (TGG to TGA) after codon 268. CDS also appears to have a deletion of 16 amino acid residues after codon 22 in comparison to the Vibrio fischeri orthologue. The sequence has been checked and is believed to be correct 316275014388 Similar to Escherichia coli Cytochrome b561 CybB UniProt:P0ABE5 (176 aa) fasta scores: E()=8.9e-13, 41.026% id in 117 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275014389 HMMPfam hit to PF01292, Cytochrome b561 family,score 3e-12 316275014391 Similar to Pseudoalteromonas haloplanktis Putative orphan protein; putative transposase UniProt:Q3IIG1 (115 aa) fasta scores: E()=5.6e-32, 58.3% id in 115 aa. CDS is disrupted by the insertion of an IS element 316275014392 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275014393 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275014394 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275014395 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275014396 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=3.6e-119, 56.998% id in 493 aa. CDS contains a translational stop codon (TAG) after codon 364 316275014397 Protein of unknown function (DUF342); Region: DUF342; pfam03961 316275014398 HMMPfam hit to PF03961, Protein of unknown function (DUF342), score 3e-53 316275014399 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316275014400 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275014401 ATP binding site [chemical binding]; other site 316275014402 putative Mg++ binding site [ion binding]; other site 316275014403 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275014404 nucleotide binding region [chemical binding]; other site 316275014405 ATP-binding site [chemical binding]; other site 316275014406 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.9e-28 316275014407 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1.3e-27 316275014408 PS00690 DEAH-box subfamily ATP-dependent helicases signature. 316275014409 hypothetical protein; Provisional; Region: PRK09256 316275014410 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 316275014411 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 1.1e-24 316275014412 PS00745 Prokaryotic-type class I peptide chain release factors signature. 316275014413 hypothetical protein; Provisional; Region: PRK11020 316275014414 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 316275014415 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 316275014416 HMMPfam hit to PF05971, Protein of unknown function (DUF890), score 6.5e-165 316275014417 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014418 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275014419 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275014420 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275014421 HMMPfam hit to PF00529, HlyD family secretion protein, score 2e-24 316275014422 Similar to Escherichia coli OqxB UniProt:Q69HW2 (1050 aa) fasta scores: E()=5.7e-42, 53.571% id in 224 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014424 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014425 Putative transposase; Region: Y2_Tnp; pfam04986 316275014426 putative outer membrane lipoprotein; Provisional; Region: PRK09967 316275014427 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275014428 ligand binding site [chemical binding]; other site 316275014429 HMMPfam hit to PF00691, OmpA family, score 1.9e-16 316275014430 PS00018 EF-hand calcium-binding domain. 316275014431 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316275014432 HMMPfam hit to PF02321, Outer membrane efflux protein, score 4.1e-23 316275014433 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.2e-24 316275014434 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014435 Ca2+ binding site [ion binding]; other site 316275014436 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014437 Ca2+ binding site [ion binding]; other site 316275014438 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014439 Ca2+ binding site [ion binding]; other site 316275014440 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014441 Ca2+ binding site [ion binding]; other site 316275014442 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014443 Ca2+ binding site [ion binding]; other site 316275014444 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014445 Ca2+ binding site [ion binding]; other site 316275014446 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014447 Ca2+ binding site [ion binding]; other site 316275014448 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014449 Ca2+ binding site [ion binding]; other site 316275014450 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014451 Ca2+ binding site [ion binding]; other site 316275014452 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014453 Ca2+ binding site [ion binding]; other site 316275014454 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 316275014455 Ca2+ binding site [ion binding]; other site 316275014456 HMMPfam hit to PF00028, Cadherin domain, score 7.9e-05 316275014457 HMMPfam hit to PF00028, Cadherin domain, score 2.4e-05 316275014458 HMMPfam hit to PF00028, Cadherin domain, score 2.9e-07 316275014459 HMMPfam hit to PF00028, Cadherin domain, score 2e-06 316275014460 HMMPfam hit to PF00028, Cadherin domain, score 8.1e-06 316275014461 HMMPfam hit to PF00028, Cadherin domain, score 1.7e-07 316275014462 HMMPfam hit to PF00028, Cadherin domain, score 0.00011 316275014463 HMMPfam hit to PF00028, Cadherin domain, score 1.9e-05 316275014464 HMMPfam hit to PF00028, Cadherin domain, score 0.00026 316275014465 HMMPfam hit to PF00028, Cadherin domain, score 3.3e-05 316275014466 HMMPfam hit to PF00028, Cadherin domain, score 6.2e-07 316275014467 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 5.7 316275014468 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 6.3 316275014469 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.013 316275014470 PS00330 Hemolysin-type calcium-binding region signature. 316275014471 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.0024 316275014472 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 316275014473 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 316275014474 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 316275014475 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase, score 6.3e-30 316275014476 PS01064 Pyridoxamine 5'-phosphate oxidase signature. 316275014477 CDS is truncated by the insertion of a downstream IS element. Also, the N-terminal part of the CDS seems to be truncated 316275014478 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275014479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014480 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275014481 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275014482 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275014483 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014485 Similar to Pseudoalteromonas haloplanktis Putative orphan protein; putative transposase UniProt:Q3IIG2 (99 aa) fasta scores: E()=0.053, 35.3% id in 51 aa. CDS contains a frameshift and a 32 aa residue deletion after codon 55 316275014486 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 316275014487 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 316275014488 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316275014489 Sel1-like repeats; Region: SEL1; smart00671 316275014490 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family,score 1.2e-81 316275014492 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275014493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014494 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275014495 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275014496 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275014497 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014499 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275014500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275014501 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275014502 HMMPfam hit to PF00529, HlyD family secretion protein, score 4e-11 316275014503 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275014504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275014505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275014506 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 316275014507 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 4.2e-15 316275014508 Domain of unknown function (DUF368); Region: DUF368; pfam04018 316275014510 HMMPfam hit to PF04018, Domain of unknown function (DUF368), score 9.7e-116 316275014511 transcriptional regulator MalT; Provisional; Region: PRK04841 316275014512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316275014513 DNA binding residues [nucleotide binding] 316275014514 dimerization interface [polypeptide binding]; other site 316275014515 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR family, score 9.8e-23 316275014516 PS00622 Bacterial regulatory proteins, luxR family signature. 316275014517 Predicted helix-turn-helix motif with score 1294.000, SD 3.59 at aa 854-875, sequence FSNEQIAAEFDVAPTTIKTHIR 316275014518 HMMPfam hit to PF07721, Tetratricopeptide repeat,score 0.0042 316275014519 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 316275014520 homodimer interface [polypeptide binding]; other site 316275014521 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 316275014522 active site pocket [active] 316275014523 HMMPfam hit to PF00343, Carbohydrate phosphorylase,score 0 316275014524 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 316275014525 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 316275014526 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 316275014527 HMMPfam hit to PF02446, 4-alpha-glucanotransferase,score 4.7e-157 316275014528 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 316275014529 Similar to Escherichia coli 1,4-alpha-glucan branching enzyme glgB UniProt:P07762 (EMBL:M13751 (728 aa) fasta scores: E()=1.5e-138, 47.411% id in 734 aa. The insertion of the downstream IS element truncates the original translational stop codon of the CDS. There is an inframe translational stop codon 10 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275014530 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 0.02 316275014531 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 4.5e-19 316275014532 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 3e-06 316275014533 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275014534 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275014535 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275014536 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014538 Similar to Shewanella putrefaciens 200 Transposase IS66 UniProt:A2UVT1 (500 aa) fasta scores: E()=1.4e-22,48.9% id in 135 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014539 Similar to Pseudomonas syringae pv. phaseolicola Transposase for insertion sequence element IS801 UniProt:P24607 (410 aa) fasta scores: E()=5.7e-69, 47.7% id in 325 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014540 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275014541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014542 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275014543 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275014544 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275014545 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014547 Similar to C-terminal part of Vibrio fischeri High-affinity iron permease UniProt:Q5DYT1 (276 aa) fasta scores: E()=1.4e-26, 87.179% id in 78 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275014549 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 316275014550 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 316275014551 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 316275014552 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569 316275014553 active site 316275014554 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 316275014555 HMMPfam hit to PF03174,Chitobiase/beta-hexosaminidase C-term, score 1.7e-34 316275014556 HMMPfam hit to PF00728, Glycosyl hydrolase family 20, catalyt, score 5.7e-167 316275014557 HMMPfam hit to PF02838, Glycosyl hydrolase family 20, domain, score 3.1e-20 316275014558 HMMPfam hit to PF03173, Putative carbohydrate binding domain, score 1.7e-77 316275014559 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 316275014560 HMMPfam hit to PF06496, Protein of unknown function (DUF1097), score 3.4e-88 316275014562 Response regulator receiver domain; Region: Response_reg; pfam00072 316275014563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275014564 active site 316275014565 phosphorylation site [posttranslational modification] 316275014566 intermolecular recognition site; other site 316275014567 dimerization interface [polypeptide binding]; other site 316275014568 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275014569 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275014570 metal binding site [ion binding]; metal-binding site 316275014571 active site 316275014572 I-site; other site 316275014573 HMMPfam hit to PF00990, GGDEF domain, score 1.2e-50 316275014574 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.4e-28 316275014575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275014576 dimer interface [polypeptide binding]; other site 316275014577 phosphorylation site [posttranslational modification] 316275014578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275014579 ATP binding site [chemical binding]; other site 316275014580 Mg2+ binding site [ion binding]; other site 316275014581 G-X-G motif; other site 316275014582 Response regulator receiver domain; Region: Response_reg; pfam00072 316275014583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275014584 active site 316275014585 phosphorylation site [posttranslational modification] 316275014586 intermolecular recognition site; other site 316275014587 dimerization interface [polypeptide binding]; other site 316275014588 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.1e-22 316275014589 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.2e-30 316275014590 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 7.8e-25 316275014592 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 316275014593 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 316275014594 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 316275014595 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275014597 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00027 316275014598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275014599 Response regulator receiver domain; Region: Response_reg; pfam00072 316275014600 active site 316275014601 phosphorylation site [posttranslational modification] 316275014602 intermolecular recognition site; other site 316275014603 dimerization interface [polypeptide binding]; other site 316275014605 HMMPfam hit to PF00072, Response regulator receiver domain, score 3.9e-25 316275014606 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 316275014607 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.4e-23 316275014608 HMMPfam hit to PF02321, Outer membrane efflux protein, score 3.6e-28 316275014609 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316275014610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275014611 Walker A/P-loop; other site 316275014612 ATP binding site [chemical binding]; other site 316275014613 Q-loop/lid; other site 316275014615 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 316275014616 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014617 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 316275014618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275014619 Walker A/P-loop; other site 316275014620 ATP binding site [chemical binding]; other site 316275014621 Q-loop/lid; other site 316275014622 ABC transporter signature motif; other site 316275014623 Walker B; other site 316275014624 D-loop; other site 316275014625 H-loop/switch region; other site 316275014627 HMMPfam hit to PF00005, ABC transporter, score 5.8e-10 316275014628 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014629 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 316275014630 active site 316275014631 active site 316275014632 catalytic residues [active] 316275014633 HMMPfam hit to PF00722, Glycosyl hydrolases family,score 1.5e-35 316275014634 PS01034 Glycosyl hydrolases family 16 active sites. 316275014635 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 316275014636 PS00430 TonB-dependent receptor proteins signature 1. 316275014638 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 316275014639 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316275014640 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 316275014641 Walker A/P-loop; other site 316275014642 ATP binding site [chemical binding]; other site 316275014643 Q-loop/lid; other site 316275014644 ABC transporter signature motif; other site 316275014645 Walker B; other site 316275014646 D-loop; other site 316275014647 H-loop/switch region; other site 316275014649 HMMPfam hit to PF00005, ABC transporter, score 1.9e-56 316275014650 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014651 PS00211 ABC transporters family signature. 316275014652 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 316275014653 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275014654 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275014656 HMMPfam hit to PF00529, HlyD family secretion protein, score 4e-27 316275014658 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 316275014659 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275014661 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275014662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014663 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275014664 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275014665 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275014666 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014668 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 1.4e-31 316275014669 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) putative orphan protein putative transposase. UniProt:Q3IIG2 (EMBL:CR954246) (99 aa) fasta scores: E()=0.037, 36.000% id in 50 aa. CDS contains a frameshift and a 40 aa residue deletion after codon 55 316275014670 Similar to central part of Photobacterium profundum Hypothetical nitrate reductase large subunit UniProt:Q6LP69 (898 aa) fasta scores: E()=5.8e-11, 35.252% id in 139 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events. The CDS also appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275014671 succinylarginine dihydrolase; Provisional; Region: PRK13281 316275014672 HMMPfam hit to PF04996, Succinylarginine dihydrolase, score 7.5e-277 316275014673 Protein of unknown function (DUF2899); Region: DUF2899; pfam11449 316275014675 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 316275014676 catalytic residues [active] 316275014677 EamA-like transporter family; Region: EamA; cl17759 316275014678 rarD protein; Region: rarD; TIGR00688 316275014680 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 7.5e-06 316275014681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275014682 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275014683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275014684 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 316275014685 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 6e-34 316275014686 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 1.9e-10 316275014687 PS00041 Bacterial regulatory proteins, araC family signature. 316275014688 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 9.9e-12 316275014689 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 316275014690 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275014691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275014692 homodimer interface [polypeptide binding]; other site 316275014693 catalytic residue [active] 316275014694 HMMPfam hit to PF00155, Aminotransferase class I and II, score 2.6e-09 316275014695 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 316275014696 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 316275014697 putative active site [active] 316275014698 Zn binding site [ion binding]; other site 316275014699 HMMPfam hit to PF00246, Zinc carboxypeptidase,score 1.7e-58 316275014700 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275014701 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014702 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275014703 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275014704 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275014705 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014707 Similar to Pseudoalteromonas haloplanktis Putative orphan protein; putative transposase UniProt:Q3IIG2 (99 aa) fasta scores: E()=2.2e-06, 30.5% id in 95 aa. CDS contains a translational stop codon (TAA) after codon 70 316275014708 Predicted permeases [General function prediction only]; Region: COG0701 316275014710 HMMPfam hit to PF03773, Predicted permease, score 1.8e-40 316275014711 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014712 Putative transposase; Region: Y2_Tnp; pfam04986 316275014716 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 316275014717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275014718 DNA binding site [nucleotide binding] 316275014719 domain linker motif; other site 316275014720 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 316275014721 dimerization interface [polypeptide binding]; other site 316275014722 ligand binding site [chemical binding]; other site 316275014723 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.0013 316275014724 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.1e-08 316275014725 Predicted helix-turn-helix motif with score 1886.000, SD 5.61 at aa 12-33, sequence MTLDQIAKLAGVSKTTASYVIN 316275014726 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 316275014727 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275014728 active site 316275014729 phosphorylation site [posttranslational modification] 316275014730 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 316275014731 active site 316275014732 phosphorylation site [posttranslational modification] 316275014733 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316275014734 dimerization domain swap beta strand [polypeptide binding]; other site 316275014735 regulatory protein interface [polypeptide binding]; other site 316275014736 active site 316275014737 regulatory phosphorylation site [posttranslational modification]; other site 316275014738 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 7.4e-59 316275014739 PS00372 PTS EIIA domains phosphorylation site signature 2. 316275014740 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 6e-35 316275014741 PS00369 PTS HPR component histidine phosphorylation site signature. 316275014742 PS00589 PTS HPR component serine phosphorylation site signature. 316275014743 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 316275014744 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 316275014745 putative substrate binding site [chemical binding]; other site 316275014746 putative ATP binding site [chemical binding]; other site 316275014747 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 2.1e-55 316275014748 PS00583 pfkB family of carbohydrate kinases signature 1. 316275014749 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 316275014750 active site 316275014751 P-loop; other site 316275014752 phosphorylation site [posttranslational modification] 316275014753 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 316275014754 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 316275014755 active site 316275014756 P-loop; other site 316275014757 phosphorylation site [posttranslational modification] 316275014758 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 316275014759 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 2.2e-10 316275014760 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 2.4e-61 316275014761 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 1.6e-20 316275014763 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275014764 Similar to Vibrio fischeri Threonine efflux protein UniProt:Q5DYY8 (204 aa) fasta scores: E()=2.6e-51, 87.079% id in 178 aa. The insertion of the downstream IS element truncates the last 15 amino acid residues of the CDS. There is an inframe translational stop codon 10 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275014765 HMMPfam hit to PF01810, LysE type translocator,score 1.4e-21 316275014767 PS00107 Protein kinases ATP-binding region signature. 316275014768 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014770 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275014771 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275014772 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275014773 HMMPfam hit to PF01609, Transposase DDE domain,score 1.2e-07 316275014775 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275014776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014777 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275014778 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275014779 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275014780 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316275014781 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 316275014782 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275014783 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 316275014785 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 316275014786 peptidase T-like protein; Region: PepT-like; TIGR01883 316275014787 metal binding site [ion binding]; metal-binding site 316275014788 putative dimer interface [polypeptide binding]; other site 316275014789 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 1.9e-07 316275014790 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 2.3e-12 316275014791 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 316275014792 methionine sulfoxide reductase B; Provisional; Region: PRK00222 316275014793 SelR domain; Region: SelR; pfam01641 316275014795 HMMPfam hit to PF01625, Peptide methionine sulfoxide reductase, score 8.6e-67 316275014796 HMMPfam hit to PF01641, SelR domain, score 1.1e-76 316275014797 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 316275014798 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 316275014799 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 316275014800 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 7.3e-31 316275014801 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 2.8e-12 316275014802 HMMPfam hit to PF08279, HTH domain, score 1.6e-12 316275014803 Predicted helix-turn-helix motif with score 1205.000, SD 3.29 at aa 20-41, sequence ISIVELIEHLDVSHMTIRRDIV 316275014804 PS00894 Bacterial regulatory proteins, deoR family signature. 316275014805 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 316275014806 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 316275014807 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 1.4e-52 316275014808 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 316275014809 Similar to Escherichia coli Hypothetical protein UniProt:Q849Y1 (421 aa) fasta scores: E()=2e-28, 72.072% id in 111 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014810 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014811 Putative transposase; Region: Y2_Tnp; pfam04986 316275014812 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014813 Putative transposase; Region: Y2_Tnp; pfam04986 316275014814 Similar to Escherichia coli Trimethylamine-N-oxide reductase 2 precursor TorZ UniProt:P46923 (809 aa) fasta scores: E()=1.2e-130, 65.714% id in 490 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014815 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4.6e-101 316275014816 Similar to Escherichia coli Cytochrome c-type protein TorY UniProt:P52005 (366 aa) fasta scores: E()=1.2e-76, 53.151% id in 365 aa. CDS contains a frameshift after codon 256. The sequence has been checked and is believed to be correct 316275014817 HMMPfam hit to PF03264, NapC/NirT cytochrome c family, N-termin, score 3.2e-80 316275014819 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 316275014820 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 316275014821 N-terminal plug; other site 316275014822 ligand-binding site [chemical binding]; other site 316275014823 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 3.3e-18 316275014824 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014825 HMMPfam hit to PF00593, TonB dependent receptor,score 9.2e-23 316275014826 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 316275014827 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 316275014829 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 9.3e-42 316275014830 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 316275014832 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 1.1e-28 316275014833 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 316275014834 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 316275014835 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 1.9e-51 316275014837 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 316275014838 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 316275014840 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 1.1e-12 316275014841 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014842 Putative transposase; Region: Y2_Tnp; pfam04986 316275014843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 316275014844 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 316275014845 HMMPfam hit to PF03929, PepSY-associated TM helix,score 0.011 316275014847 HMMPfam hit to PF03929, PepSY-associated TM helix,score 0.078 316275014848 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 316275014849 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 316275014852 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316275014853 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 316275014854 intersubunit interface [polypeptide binding]; other site 316275014856 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 3.1e-24 316275014857 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 316275014858 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 316275014859 HMMPfam hit to PF00005, ABC transporter, score 2.3e-48 316275014860 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014861 PS00211 ABC transporters family signature. 316275014862 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 316275014863 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275014864 ABC-ATPase subunit interface; other site 316275014865 dimer interface [polypeptide binding]; other site 316275014866 putative PBP binding regions; other site 316275014868 HMMPfam hit to PF00950, ABC 3 transport family,score 9.3e-52 316275014869 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316275014870 intersubunit interface [polypeptide binding]; other site 316275014872 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275014873 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275014874 DNA binding site [nucleotide binding] 316275014875 active site 316275014876 Int/Topo IB signature motif; other site 316275014877 HMMPfam hit to PF00589, Phage integrase family,score 0.0026 316275014878 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=3.9e-120, 57.0% id in 493 aa. CDS is disrupted by the insertion of an IS element after codon 286 316275014879 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275014880 Putative transposase; Region: Y2_Tnp; pfam04986 316275014881 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275014882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275014883 Similar to Vibrio cholerae Transporter, NadC family UniProt:Q9KNE0 (462 aa) fasta scores: E()=7.7e-60, 71.774% id in 248 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275014885 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 316275014886 Chitin binding domain; Region: Chitin_bind_3; pfam03067 316275014887 HMMPfam hit to PF03067, Chitin binding domain,score 2.1e-33 316275014888 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 316275014889 HMMPfam hit to PF01292, Cytochrome b561 family,score 1.3e-11 316275014891 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 316275014892 HMMPfam hit to PF01863, Protein of unknown function DUF45, score 3.2e-05 316275014893 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 316275014894 HMMPfam hit to PF03692, Uncharacterised protein family (UPF0153), score 2.2e-05 316275014896 Protein of unknown function (DUF3283); Region: DUF3283; pfam11686 316275014897 hypothetical protein; Provisional; Region: PRK12378 316275014898 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 6.6e-109 316275014899 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 316275014900 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275014901 ATP binding site [chemical binding]; other site 316275014902 Mg++ binding site [ion binding]; other site 316275014903 motif III; other site 316275014904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275014905 nucleotide binding region [chemical binding]; other site 316275014906 ATP-binding site [chemical binding]; other site 316275014907 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1.8e-68 316275014908 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014909 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275014910 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.3e-32 316275014911 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275014912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275014913 metal binding site [ion binding]; metal-binding site 316275014914 active site 316275014915 I-site; other site 316275014917 HMMPfam hit to PF00990, GGDEF domain, score 3.7e-46 316275014918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275014919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275014920 metal binding site [ion binding]; metal-binding site 316275014921 active site 316275014922 I-site; other site 316275014924 HMMPfam hit to PF00990, GGDEF domain, score 3e-49 316275014925 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 316275014926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275014927 putative substrate translocation pore; other site 316275014929 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 7.5e-47 316275014930 PS00251 TNF family signature. 316275014931 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 316275014932 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275014933 ATP binding site [chemical binding]; other site 316275014934 Mg++ binding site [ion binding]; other site 316275014935 motif III; other site 316275014936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275014937 nucleotide binding region [chemical binding]; other site 316275014938 ATP-binding site [chemical binding]; other site 316275014939 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 316275014940 putative RNA binding site [nucleotide binding]; other site 316275014941 HMMPfam hit to PF03880, DbpA RNA binding domain,score 2.9e-25 316275014942 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.5e-31 316275014943 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 6.4e-62 316275014944 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275014945 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275014947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275014948 metal binding site [ion binding]; metal-binding site 316275014949 active site 316275014950 I-site; other site 316275014952 HMMPfam hit to PF00990, GGDEF domain, score 8.1e-54 316275014953 siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950 316275014954 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 316275014955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275014956 putative substrate translocation pore; other site 316275014957 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316275014959 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 1e-17 316275014960 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 316275014961 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316275014962 Walker A/P-loop; other site 316275014963 ATP binding site [chemical binding]; other site 316275014964 Q-loop/lid; other site 316275014965 ABC transporter signature motif; other site 316275014966 Walker B; other site 316275014967 D-loop; other site 316275014968 H-loop/switch region; other site 316275014969 HMMPfam hit to PF00005, ABC transporter, score 6.7e-55 316275014970 PS00017 ATP/GTP-binding site motif A (P-loop). 316275014971 PS00211 ABC transporters family signature. 316275014972 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 316275014973 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 316275014974 siderophore binding site; other site 316275014975 HMMPfam hit to PF01497, Periplasmic binding protein, score 2.7e-20 316275014976 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 316275014977 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275014978 ABC-ATPase subunit interface; other site 316275014979 dimer interface [polypeptide binding]; other site 316275014980 putative PBP binding regions; other site 316275014981 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275014982 ABC-ATPase subunit interface; other site 316275014983 dimer interface [polypeptide binding]; other site 316275014984 putative PBP binding regions; other site 316275014986 HMMPfam hit to PF01032, FecCD transport family,score 3.7e-63 316275014987 HMMPfam hit to PF01032, FecCD transport family,score 4e-53 316275014988 HMMPfam hit to PF00950, ABC 3 transport family,score 0.00047 316275014989 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 316275014990 HMMPfam hit to PF03171, 2OG-Fe(II) oxygenase superfamily, score 0.0066 316275014991 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 316275014992 dimer interface [polypeptide binding]; other site 316275014993 FMN binding site [chemical binding]; other site 316275014994 HMMPfam hit to PF00881, Nitroreductase family,score 2.7e-37 316275014995 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 316275014996 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 316275014997 putative NAD(P) binding site [chemical binding]; other site 316275014998 HMMPfam hit to PF00107, Zinc-binding dehydrogenase,score 5.7e-21 316275014999 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 1.4e-06 316275015000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275015001 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275015002 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275015003 putative effector binding pocket; other site 316275015004 dimerization interface [polypeptide binding]; other site 316275015005 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6.6e-17 316275015006 Predicted helix-turn-helix motif with score 1377.000, SD 3.88 at aa 16-37, sequence GSFSAASKIMNIPVATVSRRVS 316275015007 PS00044 Bacterial regulatory proteins, lysR family signature. 316275015008 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.9e-28 316275015009 Similar to Pseudomonas aeruginosa Hydrophobic compound transport factor HcuC UniProt:Q76LI0 (588 aa) fasta scores: E()=1.1e-95, 55.575% id in 565 aa. CDS is disrupted by the insertion of an IS element after codon 96 316275015010 HMMPfam hit to PF00005, ABC transporter, score 3.1e-67 316275015011 PS00211 ABC transporters family signature. 316275015012 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 316275015013 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015015 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 3.2e-42 316275015016 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275015017 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275015018 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275015020 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 316275015021 UbiA prenyltransferase family; Region: UbiA; pfam01040 316275015023 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 4.1e-65 316275015024 PS00943 UbiA prenyltransferase family signature. 316275015025 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 316275015027 HMMPfam hit to PF03626, Prokaryotic Cytochrome C oxidase subunit IV, score 3.2e-28 316275015028 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 316275015029 Subunit I/III interface [polypeptide binding]; other site 316275015030 Subunit III/IV interface [polypeptide binding]; other site 316275015031 HMMPfam hit to PF00510, Cytochrome c oxidase subunit III, score 5.7e-06 316275015033 Similar to Escherichia coli Ubiquinol oxidase subunit 1 CyoB UniProt:P0ABI8 (663 aa) fasta scores: E()=1.9e-195, 74.324% id in 666 aa. CDS contains a frameshift after codon 92. The sequence has been checked and is believed to be correct 316275015035 HMMPfam hit to PF00115, Cytochrome C and Quinol oxidase polypeptide, score 5.7e-252 316275015036 PS00077 Heme-copper oxidase catalytic subunit,copper B binding region signature. 316275015037 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 316275015038 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 316275015039 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 316275015040 HMMPfam hit to PF06481, COX Aromatic Rich Motif,score 1.4e-11 316275015041 HMMPfam hit to PF00116, Cytochrome C oxidase subunit II, periplasmic, score 2.1e-06 316275015043 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015044 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 316275015046 HMMPfam hit to PF07556, Protein of unknown function (DUF1538), score 1.3e-128 316275015047 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 316275015049 HMMPfam hit to PF07556, Protein of unknown function (DUF1538), score 5.5e-117 316275015050 Nitrogen regulatory protein P-II; Region: P-II; smart00938 316275015051 FOG: CBS domain [General function prediction only]; Region: COG0517 316275015052 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 316275015053 HMMPfam hit to PF00571, CBS domain pair, score 3.3e-16 316275015054 Protein of unknown function (DUF3103); Region: DUF3103; pfam11301 316275015055 CHASE3 domain; Region: CHASE3; pfam05227 316275015056 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275015057 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275015058 dimer interface [polypeptide binding]; other site 316275015059 putative CheW interface [polypeptide binding]; other site 316275015060 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 2.8e-46 316275015061 HMMPfam hit to PF00672, HAMP domain, score 0.00016 316275015063 HMMPfam hit to PF05227, CHASE3 domain, score 2e-12 316275015065 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015067 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275015068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015069 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275015070 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275015071 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275015072 N-formylglutamate amidohydrolase; Region: FGase; cl01522 316275015073 Domain of unknown function (DUF1704); Region: DUF1704; pfam08014 316275015074 HMMPfam hit to PF08014, Domain of unknown function (DUF1704), score 2.2e-176 316275015075 hypothetical protein; Provisional; Region: PRK11027 316275015076 HMMPfam hit to PF04219, Protein of unknown function, DUF, score 1.8e-15 316275015077 transcriptional regulator HdfR; Provisional; Region: PRK03601 316275015078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275015079 LysR substrate binding domain; Region: LysR_substrate; pfam03466 316275015080 dimerization interface [polypeptide binding]; other site 316275015081 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-18 316275015082 Predicted helix-turn-helix motif with score 1241.000, SD 3.41 at aa 19-40, sequence RHFGRAAEHLFLTQSAVSFRVR 316275015083 PS00044 Bacterial regulatory proteins, lysR family signature. 316275015084 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-08 316275015085 GTPase RsgA; Reviewed; Region: PRK01889 316275015086 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 316275015087 GTPase/Zn-binding domain interface [polypeptide binding]; other site 316275015088 GTP/Mg2+ binding site [chemical binding]; other site 316275015089 G4 box; other site 316275015090 G5 box; other site 316275015091 G1 box; other site 316275015092 Switch I region; other site 316275015093 G2 box; other site 316275015094 G3 box; other site 316275015095 Switch II region; other site 316275015096 HMMPfam hit to PF03193, Protein of unknown function, DUF258, score 3e-105 316275015097 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015098 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015099 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 316275015100 MgtE intracellular N domain; Region: MgtE_N; pfam03448 316275015101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 316275015102 Divalent cation transporter; Region: MgtE; cl00786 316275015103 HMMPfam hit to PF03448, MgtE intracellular domain,score 1.4e-19 316275015105 HMMPfam hit to PF01769, Divalent cation transporter, score 9.8e-15 316275015106 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 316275015107 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 316275015108 HMMPfam hit to PF04069, Substrate binding domain of ABC-type glycine, score 1.4e-55 316275015109 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316275015110 Ligand Binding Site [chemical binding]; other site 316275015111 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 316275015112 Ligand Binding Site [chemical binding]; other site 316275015113 HMMPfam hit to PF00582, Universal stress protein family, score 3.1e-15 316275015114 HMMPfam hit to PF00582, Universal stress protein family, score 4.8e-12 316275015115 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 316275015116 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 316275015117 Sulfate transporter family; Region: Sulfate_transp; pfam00916 316275015118 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 316275015119 HMMPfam hit to PF01740, STAS domain, score 2.6e-07 316275015120 HMMPfam hit to PF00916, Sulfate transporter family,score 2.9e-105 316275015122 HMMPfam hit to PF00860, Permease family, score 0.0063 316275015123 EamA-like transporter family; Region: EamA; pfam00892 316275015124 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 316275015125 EamA-like transporter family; Region: EamA; pfam00892 316275015127 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.3e-22 316275015128 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.5e-13 316275015129 SnoaL-like domain; Region: SnoaL_2; pfam12680 316275015130 Similar to Photobacterium sp. ska34 Hypothetical transcriptional regulator UniProt:Q2C726 (299 aa) fasta scores: E()=6e-39, 43.011% id in 279 aa. CDS contains a nonsense mutation (TAG) after codon 76. The sequence has been checked and is believed to be correct 316275015131 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 7.8e-14 316275015132 Predicted helix-turn-helix motif with score 2066.000, SD 6.22 at aa 7-28, sequence GSITKAADKLELSKSVISQHLK 316275015133 PS00044 Bacterial regulatory proteins, lysR family signature. 316275015134 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.7e-16 316275015135 Similar to C-terminal part of Vibrio cholerae Hypothetical protein (alkaline phosphatase) UniProt:Q9KND2 (624 aa) fasta scores: E()=2.1e-67, 77.670% id in 206 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275015136 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275015137 Putative transposase; Region: Y2_Tnp; pfam04986 316275015138 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=8e-63, 52.6% id in 287 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275015139 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015140 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015141 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275015142 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275015143 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275015144 Similar to Escherichia coli Trimethylamine-N-oxide reductase 2 precursor TorZ UniProt:P46923 (809 aa) fasta scores: E()=4e-34, 63.158% id in 152 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275015145 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 6.5e-30 316275015146 HAMP domain; Region: HAMP; pfam00672 316275015147 dimerization interface [polypeptide binding]; other site 316275015148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275015149 dimer interface [polypeptide binding]; other site 316275015150 phosphorylation site [posttranslational modification] 316275015151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275015152 ATP binding site [chemical binding]; other site 316275015153 Mg2+ binding site [ion binding]; other site 316275015154 G-X-G motif; other site 316275015155 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1e-26 316275015156 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.1e-12 316275015157 HMMPfam hit to PF00672, HAMP domain, score 3.1e-11 316275015159 Similar to Vibrio fischeri Probable transcriptional regulator SyrB UniProt:Q5E145 (221 aa) fasta scores: E()=2e-72, 94.118% id in 221 aa. CDS contains a frameshift after codon 85. The sequence has been checked and is believed to be correct 316275015160 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2e-13 316275015161 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.4e-22 316275015162 Protein of unknown function (DUF3316); Region: DUF3316; pfam11777 316275015163 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 316275015164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015165 active site 316275015166 phosphorylation site [posttranslational modification] 316275015167 intermolecular recognition site; other site 316275015168 dimerization interface [polypeptide binding]; other site 316275015169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275015170 DNA binding site [nucleotide binding] 316275015171 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.7e-35 316275015172 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 1.8e-21 316275015173 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 316275015174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 316275015175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275015176 dimer interface [polypeptide binding]; other site 316275015177 phosphorylation site [posttranslational modification] 316275015178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275015179 ATP binding site [chemical binding]; other site 316275015180 Mg2+ binding site [ion binding]; other site 316275015181 G-X-G motif; other site 316275015183 HMMPfam hit to PF00672, HAMP domain, score 0.011 316275015184 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.9e-15 316275015185 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 6.3e-28 316275015186 Similar to Photobacterium profundum 3tck Putative potassium channel related protein UniProt:Q1ZAR2 (341 aa) fasta scores: E()=8e-53, 45.593% id in 329 aa. CDS contains a frameshift after codon 54. The sequence has been checked and is believed to be correct 316275015187 HMMPfam hit to PF07885, Ion channel, score 3.9e-15 316275015189 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 316275015190 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 316275015191 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 316275015192 DNA binding site [nucleotide binding] 316275015193 active site 316275015194 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransfera, score 5.6e-43 316275015195 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 316275015196 HMMPfam hit to PF02870, 6-O-methylguanine DNA methyltransfera, score 2.9e-06 316275015197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275015198 dimerization interface [polypeptide binding]; other site 316275015199 putative DNA binding site [nucleotide binding]; other site 316275015200 putative Zn2+ binding site [ion binding]; other site 316275015201 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275015202 Putative transposase; Region: Y2_Tnp; pfam04986 316275015203 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 316275015204 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 316275015205 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 316275015206 trimer interface [polypeptide binding]; other site 316275015207 active site 316275015208 substrate binding site [chemical binding]; other site 316275015209 CoA binding site [chemical binding]; other site 316275015210 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015211 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 17 316275015212 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 16 316275015213 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.35 316275015214 CDS is truncated by the insertion of the downstream IS element. There is an inframe translational stop 8 codon amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275015215 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275015216 Putative transposase; Region: Y2_Tnp; pfam04986 316275015217 Similar to Erwinia carotovora subsp. atroseptica Hypothetical protein UniProt:Q6CZ25 (424 aa) fasta scores: E()=6.4e-61, 52.258% id in 310 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275015218 HMMPfam hit to PF07005, Protein of unknown function, DUF1537, score 3e-92 316275015219 putative aldolase; Validated; Region: PRK08130 316275015220 intersubunit interface [polypeptide binding]; other site 316275015221 active site 316275015222 Zn2+ binding site [ion binding]; other site 316275015223 HMMPfam hit to PF00596, Class II Aldolase and Adducin N-terminal, score 2.2e-67 316275015224 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 316275015225 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 4e-47 316275015226 GntP family permease; Region: GntP_permease; pfam02447 316275015227 fructuronate transporter; Provisional; Region: PRK10034; cl15264 316275015229 HMMPfam hit to PF02447, GntP family permease, score 2.1e-93 316275015230 HMMPfam hit to PF03600, Citrate transporter, score 0.00027 316275015231 HMMPfam hit to PF06808, DctM-like transporters,score 0.0014 316275015232 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 316275015233 HMMPfam hit to PF04828, Protein of unknown function (DUF636), score 7.4e-16 316275015234 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 316275015235 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 316275015236 active site 316275015237 nucleophile elbow; other site 316275015238 HMMPfam hit to PF01734, Patatin-like phospholipase,score 1.1e-08 316275015239 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 316275015240 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 316275015241 tetramer interface [polypeptide binding]; other site 316275015242 heme binding pocket [chemical binding]; other site 316275015243 NADPH binding site [chemical binding]; other site 316275015244 HMMPfam hit to PF00199, Catalase, score 9e-286 316275015245 PS00438 Catalase proximal active site signature. 316275015246 PS00437 Catalase proximal heme-ligand signature. 316275015247 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 316275015248 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 316275015249 active site residue [active] 316275015250 HMMPfam hit to PF00581, Rhodanese-like domain,score 2.7e-14 316275015251 Chitin binding domain; Region: Chitin_bind_3; pfam03067 316275015252 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 316275015253 aromatic chitin/cellulose binding site residues [chemical binding]; other site 316275015254 HMMPfam hit to PF03067, Chitin binding domain,score 2.4e-65 316275015255 HMMPfam hit to PF02839, Carbohydrate binding domain, score 4e-09 316275015256 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 316275015257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275015258 Walker A/P-loop; other site 316275015259 ATP binding site [chemical binding]; other site 316275015260 Q-loop/lid; other site 316275015261 ABC transporter signature motif; other site 316275015262 Walker B; other site 316275015263 D-loop; other site 316275015264 H-loop/switch region; other site 316275015265 ABC transporter; Region: ABC_tran_2; pfam12848 316275015266 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275015267 HMMPfam hit to PF00005, ABC transporter, score 2.7e-42 316275015268 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015269 HMMPfam hit to PF00005, ABC transporter, score 1.1e-37 316275015270 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015271 PS00211 ABC transporters family signature. 316275015272 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275015273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015274 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275015275 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275015276 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275015277 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015279 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275015280 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 316275015281 active site 316275015282 catalytic site [active] 316275015283 substrate binding site [chemical binding]; other site 316275015284 HMMPfam hit to PF00929, Exonuclease, score 4e-31 316275015285 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 316275015286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275015287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275015288 HMMPfam hit to PF00440, Bacterial regulatory proteins, tetR family, score 5.8e-09 316275015289 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 316275015290 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 316275015291 DNA binding residues [nucleotide binding] 316275015292 dimer interface [polypeptide binding]; other site 316275015293 [2Fe-2S] cluster binding site [ion binding]; other site 316275015294 Predicted helix-turn-helix motif with score 991.000, SD 2.56 at aa 8-29, sequence LTIGMLSERSGVADSALRFYET 316275015295 HMMPfam hit to PF00376, MerR family regulatory protein, score 3.6e-10 316275015296 PS00552 Bacterial regulatory proteins, merR family signature. 316275015297 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) putative orphan protein putative transposase. UniProt:Q3IIG2 (EMBL:CR954246) (99 aa) fasta scores: E()=2.3e-06, 30.526% id in 95 aa. CDS contains a translational stop codon (TAA) after codon 70 316275015298 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015300 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275015301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015302 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275015303 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275015304 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275015305 serine/threonine transporter SstT; Provisional; Region: PRK13628 316275015306 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 316275015307 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 2.6e-127 316275015309 PS00099 Thiolases active site. 316275015310 PS00435 Peroxidases proximal heme-ligand signature. 316275015311 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 316275015312 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316275015313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015314 active site 316275015315 phosphorylation site [posttranslational modification] 316275015316 intermolecular recognition site; other site 316275015317 dimerization interface [polypeptide binding]; other site 316275015318 HMMPfam hit to PF01584, CheW-like domain, score 6.5e-30 316275015319 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.1e-09 316275015320 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 316275015321 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 316275015322 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 316275015323 active site 316275015324 catalytic site [active] 316275015325 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1.3e-09 316275015326 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 0.054 316275015327 Similar to Vibrio cholerae Maltose/maltodextrin import ATP-binding protein MalK UniProt:Q9KL04 (373 aa) fasta scores: E()=3.7e-34, 67.133% id in 143 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275015328 HMMPfam hit to PF08402, TOBE domain, score 1.1e-07 316275015329 HMMPfam hit to PF03459, TOBE domain, score 2.3e-08 316275015330 HMMPfam hit to PF03459, TOBE domain, score 1e-06 316275015331 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015333 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275015334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015335 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275015336 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275015337 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275015338 Uncharacterized conserved protein [Function unknown]; Region: COG1434 316275015339 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316275015340 putative active site [active] 316275015341 HMMPfam hit to PF02698, DUF218 domain, score 2.4e-34 316275015342 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 316275015343 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 316275015344 ligand binding site; other site 316275015345 oligomer interface; other site 316275015346 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 316275015347 dimer interface [polypeptide binding]; other site 316275015348 N-terminal domain interface [polypeptide binding]; other site 316275015349 sulfate 1 binding site; other site 316275015350 HMMPfam hit to PF00483, Nucleotidyl transferase,score 1e-75 316275015351 PS00809 ADP-glucose pyrophosphorylase signature 2. 316275015352 PS00810 ADP-glucose pyrophosphorylase signature 3. 316275015353 glycogen synthase; Provisional; Region: glgA; PRK00654 316275015354 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 316275015355 ADP-binding pocket [chemical binding]; other site 316275015356 homodimer interface [polypeptide binding]; other site 316275015357 HMMPfam hit to PF08323, Starch synthase catalytic domain, score 1.2e-74 316275015358 HMMPfam hit to PF00534, Glycosyl transferases group, score 4e-10 316275015359 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 316275015361 HMMPfam hit to PF06912, Protein of unknown function (DUF1275), score 9.5e-32 316275015362 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015364 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275015365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015366 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275015367 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275015368 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275015369 Similar to Photobacterium profundum Hypothetical nitrate reductase large subunit UniProt:Q6LP69 (898 aa) fasta scores: E()=7.5e-96, 63.158% id in 380 aa. CDS contains a frameshift after codon 71 and is truncated by the insertion of the downstream IS element. The sequence has been checked and is believed to be correct 316275015370 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 1.8e-14 316275015371 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 316275015372 nitrite reductase subunit NirD; Provisional; Region: PRK14989 316275015373 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275015374 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275015375 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316275015376 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316275015377 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 316275015378 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoredu, score 6e-45 316275015379 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 0.00077 316275015380 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoredu, score 5.1e-19 316275015381 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 1.2e-15 316275015382 HMMPfam hit to PF03460, Nitrite/Sulfite reductase ferredoxin-lik, score 2.7e-18 316275015383 HMMPfam hit to PF01077, Nitrite and sulphite reductase 4Fe-4S do, score 8e-47 316275015384 PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 316275015385 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 316275015386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275015387 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 316275015388 putative substrate translocation pore; other site 316275015389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275015391 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.4e-38 316275015392 PS00216 Sugar transport proteins signature 1. 316275015393 Protein phosphatase 2C; Region: PP2C; pfam00481 316275015394 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 316275015395 active site 316275015396 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 316275015397 Catalytic domain of Protein Kinases; Region: PKc; cd00180 316275015398 active site 316275015399 ATP binding site [chemical binding]; other site 316275015400 substrate binding site [chemical binding]; other site 316275015401 activation loop (A-loop); other site 316275015402 HMMPfam hit to PF00481, Protein phosphatase 2C,score 4.5e-05 316275015403 HMMPfam hit to PF00069, Protein kinase domain,score 1.7e-12 316275015404 PS00108 Serine/Threonine protein kinases active-site signature. 316275015406 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015407 Leucine rich repeat; Region: LRR_8; pfam13855 316275015408 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 316275015409 active site 316275015410 ATP binding site [chemical binding]; other site 316275015411 substrate binding site [chemical binding]; other site 316275015412 activation loop (A-loop); other site 316275015413 HMMPfam hit to PF00069, Protein kinase domain,score 0.00011 316275015414 PS00881 Protein splicing signature. 316275015415 PS00107 Protein kinases ATP-binding region signature. 316275015416 HMMPfam hit to PF00560, Leucine Rich Repeat, score 4.1 316275015417 HMMPfam hit to PF00560, Leucine Rich Repeat, score 0.43 316275015418 HMMPfam hit to PF00560, Leucine Rich Repeat, score 9.1 316275015419 HMMPfam hit to PF00560, Leucine Rich Repeat, score 0.0088 316275015420 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 316275015421 tetramerization interface [polypeptide binding]; other site 316275015422 substrate binding pocket [chemical binding]; other site 316275015423 catalytic residues [active] 316275015424 inhibitor binding sites; inhibition site 316275015425 NADP(H) binding site [chemical binding]; other site 316275015426 HMMPfam hit to PF00368,Hydroxymethylglutaryl-coenzyme A reductas, score 7.4e-61 316275015427 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015428 PS00318 Hydroxymethylglutaryl-coenzyme A reductases signature 2. 316275015429 arginine decarboxylase; Provisional; Region: PRK05354 316275015430 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 316275015431 dimer interface [polypeptide binding]; other site 316275015432 active site 316275015433 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 316275015434 catalytic residues [active] 316275015435 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 316275015436 HMMPfam hit to PF02784, Pyridoxal-dependent decarboxylase, py, score 6.8e-73 316275015437 HMMPfam hit to PF00278, Pyridoxal-dependent decarboxylase, C-, score 3e-50 316275015438 Similar to Escherichia coli Agmatinase SpeB UniProt:P60651 (306 aa) fasta scores: E()=2.7e-71, 61.311% id in 305 aa. CDS is disrupted by the insertion of an IS element after codon 172. In addition the CDS contains a frameshift after codon 68. The sequence has been checked and is believed to be correct 316275015439 PS00041 Bacterial regulatory proteins, araC family signature. 316275015440 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015441 PS00147 Arginase family signature 1. 316275015442 PS00148 Arginase family signature 2. 316275015443 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275015444 Putative transposase; Region: Y2_Tnp; pfam04986 316275015445 PS01053 Arginase family signature 3. 316275015446 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=2.1e-118, 56.998% id in 493 aa. CDS contains a frameshift after codon 436 316275015447 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015448 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015449 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275015450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275015451 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275015453 classical (c) SDRs; Region: SDR_c; cd05233 316275015454 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 316275015455 NAD(P) binding site [chemical binding]; other site 316275015456 active site 316275015457 HMMPfam hit to PF00106, short chain dehydrogenase,score 8.9e-08 316275015458 PS00061 Short-chain dehydrogenases/reductases family signature. 316275015459 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 316275015460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275015461 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 316275015462 NAD(P) binding site [chemical binding]; other site 316275015463 active site 316275015464 HMMPfam hit to PF01073, 3-beta hydroxysteroid dehydrogenase/iso, score 4.2e-10 316275015465 HMMPfam hit to PF01370, NAD dependent epimerase/dehydratase fam, score 3.8e-18 316275015466 HMMPfam hit to PF07993, Male sterility protein,score 5.5e-10 316275015467 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 316275015468 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275015469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275015470 Predicted helix-turn-helix motif with score 1286.000, SD 3.57 at aa 284-305, sequence CSLELVANALNIHPRSLQNQLK 316275015471 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.5e-08 316275015472 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 316275015473 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316275015474 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316275015475 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 316275015476 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 316275015477 ligand binding site [chemical binding]; other site 316275015479 HMMPfam hit to PF05359, Domain of Unknown Function (DUF748), score 3.4e-07 316275015480 HMMPfam hit to PF05359, Domain of Unknown Function (DUF748), score 1e-29 316275015481 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275015482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015483 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275015484 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275015485 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275015486 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015488 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 5.1e-32 316275015489 Similar to Pseudoalteromonas haloplanktis Putative orphan protein; putative transposase UniProt:Q3IIG2 (99 aa) fasta scores: E()=0.041, 35.3% id in 51 aa. CDS contains a frameshift and a deletion of 32 amino acid residues after codon 55 316275015490 Similar to Vibrio mimicus Aerobactin synthetase IucA UniProt:Q76BS7 (598 aa) fasta scores: E()=1.3e-135,61.060% id in 547 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275015491 HMMPfam hit to PF04183, IucA / IucC family, score 2.4e-104 316275015492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 316275015493 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 316275015494 HMMPfam hit to PF04183, IucA / IucC family, score 3.8e-124 316275015495 Homeodomain-like domain; Region: HTH_23; cl17451 316275015496 Winged helix-turn helix; Region: HTH_29; pfam13551 316275015497 Homeodomain-like domain; Region: HTH_32; pfam13565 316275015498 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275015499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275015500 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 316275015501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275015502 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275015503 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 316275015504 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 316275015505 N-terminal plug; other site 316275015506 ligand-binding site [chemical binding]; other site 316275015507 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 8.7e-18 316275015508 HMMPfam hit to PF00593, TonB dependent receptor,score 2.5e-18 316275015509 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 316275015510 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 316275015512 HMMPfam hit to PF01145, SPFH domain / Band, score 4.9e-83 316275015513 PS01270 Band 7 protein family signature. 316275015514 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 316275015515 HMMPfam hit to PF01957, Nodulation efficiency protein D (NfeD), score 1.2e-30 316275015517 Similar to Vibrio fischeri Methyl-accepting chemotaxis protein UniProt:Q5E156 (541 aa) fasta scores: E()=4.1e-146, 83.179% id in 541 aa. CDS contains a nonsense mutation (AAA to TAA) after codon 34. The sequence has been checked and is believed to be correct 316275015518 HMMPfam hit to PF00672, HAMP domain, score 5.4e-06 316275015519 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 8.3e-59 316275015520 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 316275015521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275015522 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 316275015523 HMMPfam hit to PF01609, Transposase DDE domain,score 7.6e-28 316275015524 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 316275015525 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 316275015526 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 1.4e-74 316275015527 PS00895 3-hydroxyisobutyrate dehydrogenase signature. 316275015528 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 316275015529 active site 316275015530 catalytic triad [active] 316275015531 oxyanion hole [active] 316275015532 switch loop; other site 316275015533 HMMPfam hit to PF00657, GDSL-like Lipase/Acylhydrolase, score 2.4e-32 316275015534 PS01098 Lipolytic enzymes G-D-S-L family, serine active site. 316275015535 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 316275015536 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316275015537 Walker A/P-loop; other site 316275015538 ATP binding site [chemical binding]; other site 316275015539 Q-loop/lid; other site 316275015540 ABC transporter signature motif; other site 316275015541 Walker B; other site 316275015542 D-loop; other site 316275015543 H-loop/switch region; other site 316275015544 HMMPfam hit to PF00005, ABC transporter, score 4.1e-60 316275015545 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015546 PS00211 ABC transporters family signature. 316275015547 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 316275015548 FtsX-like permease family; Region: FtsX; pfam02687 316275015550 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015551 HMMPfam hit to PF02687, Predicted permease, score 4.9e-12 316275015552 HMMPfam hit to PF02687, Predicted permease, score 1.4e-11 316275015553 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 316275015554 HMMPfam hit to PF04076, Domain unknown function (DUF388), score 1.5e-17 316275015555 Cytochrome b562; Region: Cytochrom_B562; pfam07361 316275015556 HMMPfam hit to PF07361, Cytochrome b562, score 1.1e-24 316275015557 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 316275015558 classical (c) SDRs; Region: SDR_c; cd05233 316275015559 NAD(P) binding site [chemical binding]; other site 316275015560 active site 316275015561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275015562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275015563 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275015564 putative effector binding pocket; other site 316275015565 dimerization interface [polypeptide binding]; other site 316275015566 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-16 316275015567 Predicted helix-turn-helix motif with score 1493.000, SD 4.27 at aa 15-36, sequence GNMSETSRIFDVQPSSISRQLA 316275015568 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.3e-41 316275015569 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 316275015570 catalytic residues [active] 316275015571 HMMPfam hit to PF00462, Glutaredoxin, score 1e-09 316275015572 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 316275015573 HMMPfam hit to PF07209, Protein of unknown function (DUF1415), score 1.1e-116 316275015574 GAF domain; Region: GAF; pfam01590 316275015575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275015576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275015577 active site 316275015578 I-site; other site 316275015579 metal binding site [ion binding]; metal-binding site 316275015580 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275015581 HMMPfam hit to PF00563, EAL domain, score 2.4e-94 316275015582 HMMPfam hit to PF00990, GGDEF domain, score 0.00075 316275015583 HMMPfam hit to PF01590, GAF domain, score 3.2e-09 316275015584 PS00430 TonB-dependent receptor proteins signature 1. 316275015585 Bacterial sugar transferase; Region: Bac_transf; pfam02397 316275015586 HMMPfam hit to PF02397, Bacterial sugar transferase, score 5.1e-22 316275015588 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 316275015589 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316275015590 DXD motif; other site 316275015592 HMMPfam hit to PF00535, Glycosyl transferase family, score 6.7e-08 316275015593 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 316275015594 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316275015595 HMMPfam hit to PF00534, Glycosyl transferases group, score 2.1e-35 316275015596 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 316275015598 HMMPfam hit to PF02706, Chain length determinant protein, score 0.00069 316275015599 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 316275015600 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275015601 putative homodimer interface [polypeptide binding]; other site 316275015602 HMMPfam hit to PF00534, Glycosyl transferases group, score 0.00062 316275015603 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 316275015604 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 316275015605 trimer interface [polypeptide binding]; other site 316275015606 active site 316275015607 substrate binding site [chemical binding]; other site 316275015608 CoA binding site [chemical binding]; other site 316275015609 PS00101 Hexapeptide-repeat containing-transferases signature. 316275015610 HMMPfam hit to PF00132, no description, score 0.061 316275015611 HMMPfam hit to PF00132, no description, score 1e+02 316275015612 HMMPfam hit to PF00132, no description, score 76 316275015613 O-Antigen ligase; Region: Wzy_C; cl04850 316275015615 HMMPfam hit to PF04932, O-Antigen Polymerase, score 3.6e-14 316275015616 PS00284 Serpins signature. 316275015617 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 316275015618 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 316275015620 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 5.9e-09 316275015621 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275015622 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316275015623 HMMPfam hit to PF00534, Glycosyl transferases group, score 0.00011 316275015624 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316275015625 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275015626 HMMPfam hit to PF00534, Glycosyl transferases group, score 1.9e-38 316275015627 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 316275015628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 316275015629 HMMPfam hit to PF00534, Glycosyl transferases group, score 2.3e-22 316275015630 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 316275015631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015632 active site 316275015633 phosphorylation site [posttranslational modification] 316275015634 intermolecular recognition site; other site 316275015635 dimerization interface [polypeptide binding]; other site 316275015636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275015637 Walker A motif; other site 316275015638 ATP binding site [chemical binding]; other site 316275015639 Walker B motif; other site 316275015640 arginine finger; other site 316275015641 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 316275015642 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 2e-08 316275015643 Predicted helix-turn-helix motif with score 1013.000, SD 2.64 at aa 470-491, sequence GNVLNAAVLLELSPSTLYRKKQ 316275015644 PS00881 Protein splicing signature. 316275015645 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275015646 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 1.9e-134 316275015647 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00031 316275015648 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.9e-27 316275015649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275015650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275015651 dimer interface [polypeptide binding]; other site 316275015652 phosphorylation site [posttranslational modification] 316275015653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275015654 ATP binding site [chemical binding]; other site 316275015655 Mg2+ binding site [ion binding]; other site 316275015656 G-X-G motif; other site 316275015657 Response regulator receiver domain; Region: Response_reg; pfam00072 316275015658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015659 active site 316275015660 phosphorylation site [posttranslational modification] 316275015661 intermolecular recognition site; other site 316275015662 dimerization interface [polypeptide binding]; other site 316275015663 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 316275015664 HMMPfam hit to PF01627, Hpt domain, score 6.7e-06 316275015665 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.1e-35 316275015666 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 6.6e-32 316275015667 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.7e-21 316275015668 HMMPfam hit to PF00672, HAMP domain, score 4.4e-07 316275015670 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316275015671 Response regulator receiver domain; Region: Response_reg; pfam00072 316275015672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015673 active site 316275015674 phosphorylation site [posttranslational modification] 316275015675 intermolecular recognition site; other site 316275015676 dimerization interface [polypeptide binding]; other site 316275015677 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316275015678 HMMPfam hit to PF07228, Stage II sporulation protein E (SpoIIE), score 1.8e-22 316275015679 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.4e-26 316275015680 AAA domain; Region: AAA_31; pfam13614 316275015681 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 316275015682 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 316275015683 SLBB domain; Region: SLBB; pfam10531 316275015684 SLBB domain; Region: SLBB; pfam10531 316275015685 SLBB domain; Region: SLBB; pfam10531 316275015686 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 316275015687 SLBB domain; Region: SLBB; pfam10531 316275015688 HMMPfam hit to PF02563, Polysaccharide biosynthesis/export protei, score 1.1e-12 316275015689 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316275015690 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275015691 ligand binding site [chemical binding]; other site 316275015692 HMMPfam hit to PF00691, OmpA family, score 9.8e-13 316275015693 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015694 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316275015695 anti sigma factor interaction site; other site 316275015696 regulatory phosphorylation site [posttranslational modification]; other site 316275015697 HMMPfam hit to PF01740, STAS domain, score 6.8e-06 316275015698 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015699 Response regulator receiver domain; Region: Response_reg; pfam00072 316275015700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015701 active site 316275015702 phosphorylation site [posttranslational modification] 316275015703 intermolecular recognition site; other site 316275015704 dimerization interface [polypeptide binding]; other site 316275015705 HMMPfam hit to PF00072, Response regulator receiver domain, score 3e-12 316275015706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275015707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275015708 dimer interface [polypeptide binding]; other site 316275015709 phosphorylation site [posttranslational modification] 316275015710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275015711 ATP binding site [chemical binding]; other site 316275015712 Mg2+ binding site [ion binding]; other site 316275015713 G-X-G motif; other site 316275015714 Response regulator receiver domain; Region: Response_reg; pfam00072 316275015715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015716 active site 316275015717 phosphorylation site [posttranslational modification] 316275015718 intermolecular recognition site; other site 316275015719 dimerization interface [polypeptide binding]; other site 316275015720 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.6e-21 316275015721 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 3.8e-38 316275015722 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.1e-26 316275015725 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 316275015726 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 316275015727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 316275015728 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 316275015729 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 316275015730 HMMPfam hit to PF00140, Sigma-70 factor, region,score 1.1e-05 316275015731 HMMPfam hit to PF04542, Sigma-70 region, score 1.9e-16 316275015732 PS00715 Sigma-70 factors family signature 1. 316275015733 HMMPfam hit to PF04539, Sigma-70 region, score 1.2e-11 316275015734 HMMPfam hit to PF04545, Sigma-70, region, score 6e-10 316275015735 Predicted helix-turn-helix motif with score 1255.000, SD 3.46 at aa 250-271, sequence KTLEELGQDLQLSKERVRQIQT 316275015736 PS00716 Sigma-70 factors family signature 2. 316275015737 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275015738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275015739 I-site; other site 316275015740 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275015742 HMMPfam hit to PF00563, EAL domain, score 3.6e-88 316275015743 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 316275015744 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 316275015745 DXD motif; other site 316275015747 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.5e-13 316275015748 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 316275015750 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 316275015751 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015752 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 316275015753 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015754 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 316275015755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 316275015756 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 316275015757 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 316275015758 active site 316275015759 Substrate binding site; other site 316275015760 Mg++ binding site; other site 316275015761 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 316275015762 HMMPfam hit to PF00483, Nucleotidyl transferase,score 5.1e-53 316275015763 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 316275015764 anti sigma factor interaction site; other site 316275015765 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 316275015766 regulatory phosphorylation site [posttranslational modification]; other site 316275015767 HMMPfam hit to PF01740, STAS domain, score 1e-13 316275015768 Response regulator receiver domain; Region: Response_reg; pfam00072 316275015769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015770 active site 316275015771 phosphorylation site [posttranslational modification] 316275015772 intermolecular recognition site; other site 316275015773 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 316275015774 dimerization interface [polypeptide binding]; other site 316275015775 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 316275015776 HMMPfam hit to PF07228, Stage II sporulation protein E (SpoIIE), score 6.8e-40 316275015777 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.7e-21 316275015778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316275015779 active site 316275015780 Similar to Pasteurella haemolytica-like sp. Leukotoxin LktA UniProt:P55123 (947 aa) fasta scores: E()=5.5e-05, 35.965% id in 114 aa. CDS may be truncated by the insertion of the downstream IS element and appears to be truncated at the N-terminus 316275015781 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 4.8 316275015782 HMMPfam hit to PF00353, Hemolysin-type calcium-binding repeat, score 0.00071 316275015783 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275015784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015785 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275015786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275015787 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275015788 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275015789 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275015790 Similar to Vibrio vulnificus ABC-type multidrug transport system, ATPase and permease component UniProt:Q8DF85 (179 aa) fasta scores: E()=1.8e-38, 63.473% id in 167 aa. The insertion of the downstream IS element truncates the last 13 amino acid residues of the CDS. There is an inframe translational stop codon one amino acid residue further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275015792 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015793 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 316275015794 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 316275015795 putative active site [active] 316275015796 catalytic site [active] 316275015797 putative metal binding site [ion binding]; other site 316275015798 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 1.2e-41 316275015799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275015800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316275015801 putative substrate translocation pore; other site 316275015803 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.3e-22 316275015804 sugar phosphate phosphatase; Provisional; Region: PRK10513 316275015805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275015806 active site 316275015807 motif I; other site 316275015808 motif II; other site 316275015809 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 316275015810 HMMPfam hit to PF05116, Sucrose-6F-phosphate phosphohydrolase, score 0.00016 316275015811 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 7.1e-87 316275015812 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 2.3e-07 316275015813 PS01229 Hypothetical cof family signature 2. 316275015814 PS01228 Hypothetical cof family signature 1. 316275015815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316275015816 Family of unknown function (DUF633); Region: DUF633; pfam04816 316275015817 Predicted membrane protein [Function unknown]; Region: COG2855 316275015819 HMMPfam hit to PF03601, Conserved hypothetical protein, score 9.8e-39 316275015820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275015821 non-specific DNA binding site [nucleotide binding]; other site 316275015822 salt bridge; other site 316275015823 sequence-specific DNA binding site [nucleotide binding]; other site 316275015824 HMMPfam hit to PF01381, Helix-turn-helix, score 1.5e-07 316275015825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275015826 non-specific DNA binding site [nucleotide binding]; other site 316275015827 salt bridge; other site 316275015828 sequence-specific DNA binding site [nucleotide binding]; other site 316275015829 HMMPfam hit to PF01381, Helix-turn-helix, score 9e-08 316275015831 PS00216 Sugar transport proteins signature 1. 316275015832 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316275015833 putative catalytic site [active] 316275015834 putative metal binding site [ion binding]; other site 316275015835 putative phosphate binding site [ion binding]; other site 316275015836 HMMPfam hit to PF03372,Endonuclease/Exonuclease/phosphatase fa, score 1.1e-10 316275015838 Similar to Klebsiella aerogenes Arylsulfatase-activating protein AtsB UniProt:P20714 (405 aa) fasta scores: E()=3e-43, 37.430% id in 358 aa. CDS contains a frameshift after codon 119. The sequence has been checked and is believed to be correct 316275015839 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015840 HMMPfam hit to PF04055, Radical SAM superfamily,score 2.6e-15 316275015841 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275015842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275015843 Homeodomain-like domain; Region: HTH_23; cl17451 316275015844 Winged helix-turn helix; Region: HTH_29; pfam13551 316275015845 Homeodomain-like domain; Region: HTH_32; pfam13565 316275015846 Uncharacterized conserved protein [Function unknown]; Region: COG5361 316275015847 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 316275015848 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 316275015849 HMMPfam hit to PF06863, Protein of unknown function (DUF1254), score 5.1e-27 316275015850 HMMPfam hit to PF06742, Protein of unknown function (DUF1214), score 3.9e-47 316275015851 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 316275015852 HMMPfam hit to PF03349, Outer membrane protein transport protein (O, score 1.1e-57 316275015853 putative metal dependent hydrolase; Provisional; Region: PRK11598 316275015854 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 316275015855 Sulfatase; Region: Sulfatase; pfam00884 316275015857 HMMPfam hit to PF08019, Domain of unknown function (DUF1705), score 1.7e-53 316275015858 HMMPfam hit to PF00884, Sulfatase, score 1.4e-70 316275015859 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 316275015860 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 316275015861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316275015862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015863 active site 316275015864 phosphorylation site [posttranslational modification] 316275015865 intermolecular recognition site; other site 316275015866 dimerization interface [polypeptide binding]; other site 316275015867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275015868 DNA binding site [nucleotide binding] 316275015869 HMMPfam hit to PF00072, Response regulator receiver domain, score 4e-36 316275015870 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2e-09 316275015871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275015872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275015873 dimer interface [polypeptide binding]; other site 316275015874 phosphorylation site [posttranslational modification] 316275015875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275015876 ATP binding site [chemical binding]; other site 316275015877 Mg2+ binding site [ion binding]; other site 316275015878 G-X-G motif; other site 316275015880 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.0024 316275015881 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 9.2e-11 316275015882 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015883 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 316275015884 Sulfatase; Region: Sulfatase; pfam00884 316275015885 HMMPfam hit to PF00884, Sulfatase, score 2.4e-51 316275015886 Weakly similar to Solibacter usitatus ellin6076 Hypothetical protein precursor UniProt:Q43YD2 (474 aa) fasta scores: E()=9.6e-43, 32.373% id in 451 aa. CDS is disrupted by the insertion of an IS element after codon 145 316275015887 HMMPfam hit to PF06742, Protein of unknown function (DUF1214), score 1.7e-44 316275015888 HMMPfam hit to PF06863, Protein of unknown function (DUF1254), score 5.3e-38 316275015889 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275015890 Putative transposase; Region: Y2_Tnp; pfam04986 316275015891 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275015892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275015893 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275015894 dimerization interface [polypeptide binding]; other site 316275015895 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 3.4e-14 316275015896 PS00044 Bacterial regulatory proteins, lysR family signature. 316275015897 Predicted helix-turn-helix motif with score 1453.000, SD 4.14 at aa 19-40, sequence RQTILAAKRMNLSQPTISIMLK 316275015898 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 316275015899 hypothetical protein; Provisional; Region: PRK11622 316275015900 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316275015901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015902 active site 316275015903 phosphorylation site [posttranslational modification] 316275015904 intermolecular recognition site; other site 316275015905 dimerization interface [polypeptide binding]; other site 316275015906 EAL domain; Region: EAL; pfam00563 316275015907 HMMPfam hit to PF00072, Response regulator receiver domain, score 5.8e-06 316275015908 HMMPfam hit to PF00563, EAL domain, score 8.7e-06 316275015909 Hpt domain; Region: Hpt; pfam01627 316275015910 putative binding surface; other site 316275015911 active site 316275015912 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 316275015913 HMMPfam hit to PF04964, Flp/Fap pilin component,score 1.1e-08 316275015915 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 316275015917 HMMPfam hit to PF01478, Type IV leader peptidase family, score 1.2e-07 316275015918 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 316275015920 HMMPfam hit to PF06981, Flp pilus assembly protein CpaB, score 8.8e-05 316275015921 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 316275015922 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 316275015923 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 316275015924 HMMPfam hit to PF00263, Bacterial type II and III secretion system p, score 6.6e-49 316275015925 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275015926 septum site-determining protein MinD; Region: minD_bact; TIGR01968 316275015927 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 316275015928 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 316275015929 ATP binding site [chemical binding]; other site 316275015930 Walker A motif; other site 316275015931 hexamer interface [polypeptide binding]; other site 316275015932 Walker B motif; other site 316275015933 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 2.1e-98 316275015934 PS00227 Tubulin subunits alpha, beta, and gamma signature. 316275015935 PS00017 ATP/GTP-binding site motif A (P-loop). 316275015936 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 316275015937 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316275015939 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 3.7e-13 316275015940 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 316275015941 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 316275015943 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 2.7e-12 316275015944 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 316275015945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 316275015946 binding surface 316275015947 TPR motif; other site 316275015948 TadE-like protein; Region: TadE; pfam07811 316275015951 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 316275015952 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 316275015953 von Willebrand factor type A domain; Region: VWA_2; pfam13519 316275015955 HMMPfam hit to PF00092, von Willebrand factor type A domain, score 0.00082 316275015956 Similar to Vibrio fischeri Outer membrane protein UniProt:Q5E7H8 (219 aa) fasta scores: E()=1.1e-22, 36.279% id in 215 aa. CDS contains a nonsense mutation (to TAA) after codon 90. The sequence has been checked and is believed to be correct 316275015957 HMMPfam hit to PF00691, OmpA family, score 1.5e-15 316275015958 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 316275015959 active site 316275015961 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275015962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275015963 dimer interface [polypeptide binding]; other site 316275015964 phosphorylation site [posttranslational modification] 316275015965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275015966 ATP binding site [chemical binding]; other site 316275015967 Mg2+ binding site [ion binding]; other site 316275015968 G-X-G motif; other site 316275015969 Response regulator receiver domain; Region: Response_reg; pfam00072 316275015970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275015971 active site 316275015972 phosphorylation site [posttranslational modification] 316275015973 intermolecular recognition site; other site 316275015974 dimerization interface [polypeptide binding]; other site 316275015975 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.3e-16 316275015976 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.4e-32 316275015977 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1e-19 316275015978 HMMPfam hit to PF00672, HAMP domain, score 1.6e-08 316275015980 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 316275015981 HMMPfam hit to PF01048, Phosphorylase family, score 5.5e-11 316275015982 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 316275015983 amphipathic channel; other site 316275015984 Asn-Pro-Ala signature motifs; other site 316275015985 HMMPfam hit to PF00230, Major intrinsic protein,score 6.9e-72 316275015987 PS00221 MIP family signature. 316275015988 glycerol kinase; Provisional; Region: glpK; PRK00047 316275015989 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 316275015990 N- and C-terminal domain interface [polypeptide binding]; other site 316275015991 active site 316275015992 MgATP binding site [chemical binding]; other site 316275015993 catalytic site [active] 316275015994 metal binding site [ion binding]; metal-binding site 316275015995 glycerol binding site [chemical binding]; other site 316275015996 homotetramer interface [polypeptide binding]; other site 316275015997 homodimer interface [polypeptide binding]; other site 316275015998 FBP binding site [chemical binding]; other site 316275015999 protein IIAGlc interface [polypeptide binding]; other site 316275016000 HMMPfam hit to PF00370, FGGY family of carbohydrate kinases, N-termi, score 1.2e-121 316275016001 PS00933 FGGY family of carbohydrate kinases signature 1. 316275016002 HMMPfam hit to PF02782, FGGY family of carbohydrate kinases, C-termi, score 5.3e-94 316275016003 PS00445 FGGY family of carbohydrate kinases signature 2. 316275016004 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 316275016005 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 316275016006 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 316275016007 HMMPfam hit to PF08220, DeoR-like helix-turn-helix domain, score 1.7e-28 316275016008 HMMPfam hit to PF08279, HTH domain, score 0.00031 316275016009 PS00894 Bacterial regulatory proteins, deoR family signature. 316275016010 Predicted helix-turn-helix motif with score 1701.000, SD 4.98 at aa 20-41, sequence VSTEDLVEQFKVSPQTIRRDLN 316275016011 HMMPfam hit to PF00455, Bacterial regulatory proteins, deoR family, score 9.2e-68 316275016012 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 316275016014 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.3e-67 316275016015 PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 316275016016 PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 316275016017 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275016018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275016019 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275016020 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275016021 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275016022 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275016023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275016024 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275016025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275016026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275016027 metal binding site [ion binding]; metal-binding site 316275016028 active site 316275016029 I-site; other site 316275016030 HMMPfam hit to PF00990, GGDEF domain, score 8.7e-23 316275016031 HMMPfam hit to PF00563, EAL domain, score 1.3e-10 316275016032 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 316275016033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 316275016034 putative active site [active] 316275016035 heme pocket [chemical binding]; other site 316275016036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275016037 dimer interface [polypeptide binding]; other site 316275016038 phosphorylation site [posttranslational modification] 316275016039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275016040 ATP binding site [chemical binding]; other site 316275016041 Mg2+ binding site [ion binding]; other site 316275016042 G-X-G motif; other site 316275016043 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316275016044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275016045 active site 316275016046 phosphorylation site [posttranslational modification] 316275016047 intermolecular recognition site; other site 316275016048 dimerization interface [polypeptide binding]; other site 316275016049 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 316275016050 putative binding surface; other site 316275016051 active site 316275016052 HMMPfam hit to PF01627, Hpt domain, score 7.7e-08 316275016053 HMMPfam hit to PF00072, Response regulator receiver domain, score 6.6e-21 316275016054 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 2.5e-40 316275016055 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 3.1e-25 316275016056 HMMPfam hit to PF08448, PAS fold, score 3.1e-12 316275016057 HMMPfam hit to PF08447, PAS fold, score 1e-07 316275016058 HMMPfam hit to PF00989, PAS fold, score 4.6e-12 316275016060 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 316275016061 HMMPfam hit to PF03150, Di-haem cytochrome c peroxidase, score 9e-42 316275016063 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 316275016064 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 316275016065 Cysteine-rich domain; Region: CCG; pfam02754 316275016066 Cysteine-rich domain; Region: CCG; pfam02754 316275016067 HMMPfam hit to PF02754, Cysteine-rich domain, score 4e-14 316275016068 HMMPfam hit to PF02754, Cysteine-rich domain, score 7.6e-05 316275016069 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00084 316275016070 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275016071 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275016072 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 316275016073 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 316275016074 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0012 316275016075 HMMPfam hit to PF00890, FAD binding domain, score 9.2e-64 316275016076 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275016077 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 316275016078 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 316275016079 HMMPfam hit to PF04324, BFD-like [2Fe-2S] binding domain, score 9.1e-20 316275016080 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 4.2e-66 316275016081 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 316275016082 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316275016083 catalytic loop [active] 316275016084 iron binding site [ion binding]; other site 316275016085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 316275016086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 316275016087 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 316275016088 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 316275016089 4Fe-4S binding domain; Region: Fer4; pfam00037 316275016090 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 316275016091 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 316275016092 [4Fe-4S] binding site [ion binding]; other site 316275016093 molybdopterin cofactor binding site; other site 316275016094 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 316275016095 molybdopterin cofactor binding site; other site 316275016096 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding do, score 8e-05 316275016097 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidor, score 1.1e-08 316275016098 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidor, score 0.0008 316275016099 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00015 316275016100 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 1e-05 316275016101 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275016102 HMMPfam hit to PF04879, Molybdopterin oxidoreductase Fe4S4 do, score 1.8e-21 316275016103 PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 316275016104 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 2.3e-125 316275016105 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 316275016106 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 3.2e-42 316275016107 peptidase T; Region: peptidase-T; TIGR01882 316275016108 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 316275016109 metal binding site [ion binding]; metal-binding site 316275016110 dimer interface [polypeptide binding]; other site 316275016111 HMMPfam hit to PF01546, Peptidase family M20/M25/M40, score 8.3e-08 316275016112 HMMPfam hit to PF07687, Peptidase dimerisation domain, score 4e-21 316275016113 HMMPfam hit to PF05343, M42 glutamyl aminopeptidase, score 0.0018 316275016114 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 316275016115 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 316275016116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275016117 non-specific DNA binding site [nucleotide binding]; other site 316275016118 salt bridge; other site 316275016119 sequence-specific DNA binding site [nucleotide binding]; other site 316275016120 Predicted helix-turn-helix motif with score 1550.000, SD 4.47 at aa 24-45, sequence LSNTQISTACNVSTRTVINWTS 316275016121 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 316275016122 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 316275016123 Predicted helix-turn-helix motif with score 1543.000, SD 4.44 at aa 179-200, sequence TSLSEWASRNHTTERTLSRHCQ 316275016124 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 0.0014 316275016125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 316275016126 HMMPfam hit to PF04237, Protein of unknown function (DUF419), score 2.2e-24 316275016127 CHASE domain; Region: CHASE; cl01369 316275016128 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275016129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275016130 metal binding site [ion binding]; metal-binding site 316275016131 active site 316275016132 I-site; other site 316275016134 HMMPfam hit to PF03924, CHASE domain, score 1.5e-14 316275016135 HMMPfam hit to PF00990, GGDEF domain, score 5.2e-09 316275016136 malate synthase; Provisional; Region: PRK08951 316275016137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 316275016138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275016139 non-specific DNA binding site [nucleotide binding]; other site 316275016140 salt bridge; other site 316275016141 sequence-specific DNA binding site [nucleotide binding]; other site 316275016142 Domain of unknown function (DUF955); Region: DUF955; cl01076 316275016143 Protein of unknown function (DUF3612); Region: DUF3612; pfam12268 316275016144 HMMPfam hit to PF01381, Helix-turn-helix, score 5.1e-08 316275016145 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 316275016146 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 316275016147 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 316275016148 TrkA-N domain; Region: TrkA_N; pfam02254 316275016149 HMMPfam hit to PF02254, TrkA-N domain, score 1.7e-33 316275016151 HMMPfam hit to PF00999, Sodium/hydrogen exchanger family, score 2.9e-58 316275016152 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 316275016153 HMMPfam hit to PF02525, Flavodoxin-like fold, score 2.3e-47 316275016154 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 316275016156 HMMPfam hit to PF00893, Small Multidrug Resistance protein, score 7.4e-27 316275016157 S4 domain; Region: S4_2; pfam13275 316275016158 Similar to C-terminal part of Vibrio fischeri Hypothetical phage protein UniProt:Q5E397 (628 aa) fasta scores: E()=1.2e-16, 58.586% id in 99 aa. The CDS appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275016159 NACHT domain; Region: NACHT; pfam05729 316275016160 Similar to Vibrio fischeri Putative DNA methylase UniProt:Q5E602 (285 aa) fasta scores: E()=5e-50, 76.879% id in 173 aa. CDS contains a nonsense mutation (GAA to TAA) after codon 77 and appears to be truncated at the N-terminus. The sequence has been checked and is believed to be correct 316275016161 HMMPfam hit to PF01555, DNA methylase, score 8.6e-08 316275016162 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 316275016166 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 316275016167 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 316275016168 MOSC domain; Region: MOSC; pfam03473 316275016169 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 316275016170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 316275016171 catalytic loop [active] 316275016172 iron binding site [ion binding]; other site 316275016173 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 2.4e-16 316275016174 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 316275016175 HMMPfam hit to PF03473, MOSC domain, score 2.7e-49 316275016176 HMMPfam hit to PF03476, MOSC N-terminal beta barrel domain, score 5.7e-33 316275016177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275016178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275016179 dimer interface [polypeptide binding]; other site 316275016180 phosphorylation site [posttranslational modification] 316275016181 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.3e-10 316275016183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316275016184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275016185 active site 316275016186 phosphorylation site [posttranslational modification] 316275016187 intermolecular recognition site; other site 316275016188 dimerization interface [polypeptide binding]; other site 316275016189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275016190 DNA binding site [nucleotide binding] 316275016191 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 5.2e-18 316275016192 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.1e-37 316275016193 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275016194 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275016195 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275016196 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275016197 Protein of unknown function (DUF808); Region: DUF808; pfam05661 316275016198 HMMPfam hit to PF05661, Protein of unknown function (DUF808), score 3.8e-177 316275016200 Acyltransferase family; Region: Acyl_transf_3; pfam01757 316275016201 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 316275016203 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 316275016204 cleavage site 316275016205 active site 316275016206 substrate binding sites [chemical binding]; other site 316275016207 HMMPfam hit to PF00089, Trypsin, score 1.3e-31 316275016208 PS00135 Serine proteases, trypsin family, serine active site. 316275016209 Fatty acid desaturase; Region: FA_desaturase; pfam00487 316275016210 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 316275016211 Di-iron ligands [ion binding]; other site 316275016212 HMMPfam hit to PF00487, Fatty acid desaturase,score 4.5e-58 316275016214 Protein of unknown function (DUF3389); Region: DUF3389; pfam11869 316275016215 PAS domain S-box; Region: sensory_box; TIGR00229 316275016216 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275016217 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275016218 metal binding site [ion binding]; metal-binding site 316275016219 active site 316275016220 I-site; other site 316275016221 HMMPfam hit to PF00990, GGDEF domain, score 9.2e-55 316275016222 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 316275016223 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 316275016224 trimer interface [polypeptide binding]; other site 316275016225 eyelet of channel; other site 316275016226 HMMPfam hit to PF00267, Gram-negative porin, score 0.0013 316275016227 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316275016228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275016229 substrate binding pocket [chemical binding]; other site 316275016230 membrane-bound complex binding site; other site 316275016231 hinge residues; other site 316275016232 HAMP domain; Region: HAMP; pfam00672 316275016233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275016235 HMMPfam hit to PF00672, HAMP domain, score 1.1e-06 316275016236 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 316275016237 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275016238 ATP binding site [chemical binding]; other site 316275016239 Mg++ binding site [ion binding]; other site 316275016240 motif III; other site 316275016241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275016242 nucleotide binding region [chemical binding]; other site 316275016243 ATP-binding site [chemical binding]; other site 316275016244 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 2.2e-70 316275016245 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016246 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275016247 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 7.4e-33 316275016248 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E0K1 (292 aa) fasta scores: E()=1.6e-91, 81.229% id in 293 aa. CDS contains a nonsense mutation (CAA to TAA) after codon 250. The sequence has been checked and is believed to be correct 316275016249 Surface antigen; Region: Bac_surface_Ag; pfam01103 316275016250 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 316275016252 BCCT family transporter; Region: BCCT; pfam02028 316275016253 HMMPfam hit to PF02028, BCCT family transporter,score 2.2e-175 316275016255 PS01303 BCCT family of transporters signature. 316275016256 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 316275016257 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275016258 HMMPfam hit to PF00529, HlyD family secretion protein, score 1.1e-24 316275016260 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 316275016262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275016263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275016264 metal binding site [ion binding]; metal-binding site 316275016265 active site 316275016266 I-site; other site 316275016267 HMMPfam hit to PF00990, GGDEF domain, score 9.8e-37 316275016269 Late competence development protein ComFB; Region: ComFB; pfam10719 316275016270 exoribonuclease II; Provisional; Region: PRK05054 316275016271 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 316275016272 RNB domain; Region: RNB; pfam00773 316275016273 S1 RNA binding domain; Region: S1; pfam00575 316275016274 HMMPfam hit to PF00575, S1 RNA binding domain,score 6.6e-06 316275016275 PS01175 Ribonuclease II family signature. 316275016276 HMMPfam hit to PF00773, RNB-like protein, score 3.7e-76 316275016277 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016278 HMMPfam hit to PF08206, Ribonuclease B OB domain,score 3.8e-23 316275016279 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275016280 DEAD-like helicases superfamily; Region: DEXDc; smart00487 316275016281 ATP binding site [chemical binding]; other site 316275016282 Mg++ binding site [ion binding]; other site 316275016283 motif III; other site 316275016284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275016285 nucleotide binding region [chemical binding]; other site 316275016286 ATP-binding site [chemical binding]; other site 316275016287 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 316275016288 putative RNA binding site [nucleotide binding]; other site 316275016289 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 5.6e-69 316275016290 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016291 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275016292 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.1e-34 316275016293 HMMPfam hit to PF03880, DbpA RNA binding domain,score 3.1e-33 316275016294 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316275016295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275016296 Coenzyme A binding pocket [chemical binding]; other site 316275016297 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.1e-19 316275016299 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275016300 Putative transposase; Region: Y2_Tnp; pfam04986 316275016301 Similar to Vibrio fischeri Methyl-accepting chemotaxis protein UniProt:Q5E0I7 (621 aa) fasta scores: E()=4.1e-151, 73.269% id in 621 aa. CDS contains a frameshift after codon 431. The sequence has been checked and is believed to be correct 316275016302 HMMPfam hit to PF05581, Vibrio chemotaxis protein N terminus, score 9.2e-20 316275016304 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016305 HMMPfam hit to PF02743, Cache domain, score 3.4e-21 316275016306 HMMPfam hit to PF00672, HAMP domain, score 5.2e-14 316275016307 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4.1e-51 316275016308 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275016310 dimer interface [polypeptide binding]; other site 316275016311 conserved gate region; other site 316275016312 ABC-ATPase subunit interface; other site 316275016313 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.1e-25 316275016315 Predicted helix-turn-helix motif with score 1296.000, SD 3.60 at aa 191-212, sequence KGQHEAARSLGLSTWHRYRYII 316275016316 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275016317 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316275016318 substrate binding pocket [chemical binding]; other site 316275016319 membrane-bound complex binding site; other site 316275016320 hinge residues; other site 316275016321 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 5.1e-63 316275016322 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 316275016323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275016324 dimer interface [polypeptide binding]; other site 316275016325 conserved gate region; other site 316275016326 putative PBP binding loops; other site 316275016327 ABC-ATPase subunit interface; other site 316275016328 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.1e-21 316275016330 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 316275016331 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 316275016332 Walker A/P-loop; other site 316275016333 ATP binding site [chemical binding]; other site 316275016334 Q-loop/lid; other site 316275016335 ABC transporter signature motif; other site 316275016336 Walker B; other site 316275016337 D-loop; other site 316275016338 H-loop/switch region; other site 316275016339 HMMPfam hit to PF00005, ABC transporter, score 3.4e-68 316275016340 PS00211 ABC transporters family signature. 316275016341 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016342 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 316275016343 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 316275016344 HMMPfam hit to PF00793, DAHP synthetase I family,score 5.4e-163 316275016345 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 316275016346 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 316275016347 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 316275016348 putative active site [active] 316275016349 putative metal-binding site [ion binding]; other site 316275016350 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016351 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 316275016352 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316275016353 active site 316275016354 metal binding site [ion binding]; metal-binding site 316275016355 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 316275016356 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 3.6e-16 316275016357 PS00785 5'-nucleotidase signature 1. 316275016358 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275016359 HMMPfam hit to PF02872, 5'-nucleotidase, C-terminal domain, score 7.8e-24 316275016360 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275016361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 316275016362 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275016363 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275016364 metal binding site [ion binding]; metal-binding site 316275016365 active site 316275016366 I-site; other site 316275016367 HMMPfam hit to PF00990, GGDEF domain, score 9.3e-42 316275016368 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E0H7 (489 aa) fasta scores: E()=1.6e-119,64.780% id in 477 aa. CDS is disrupted by the insertion of an IS element after codon 430 316275016369 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275016370 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275016371 Integrase core domain; Region: rve; pfam00665 316275016372 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 24-45, sequence ISAREIGQKLKRSNGSISKELR 316275016373 HMMPfam hit to PF00665, Integrase core domain,score 1.1e-31 316275016374 Predicted helix-turn-helix motif with score 1083.000, SD 2.88 at aa 291-312, sequence LEQSRVAELTNDDEQALYSYKR 316275016375 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 316275016376 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 316275016377 DNA binding residues [nucleotide binding] 316275016378 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 316275016379 HMMPfam hit to PF04198, Putative sugar-binding domain, score 9.5e-74 316275016380 Predicted helix-turn-helix motif with score 1645.000, SD 4.79 at aa 28-49, sequence ATQEEISKKFGLSRAKVGRMLR 316275016381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 316275016382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 316275016383 DNA binding residues [nucleotide binding] 316275016384 Predicted helix-turn-helix motif with score 1257.000, SD 3.47 at aa 146-167, sequence YSVREICRRLHINPKTFYDHIN 316275016385 purine nucleoside phosphorylase; Provisional; Region: PRK13374 316275016386 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 316275016387 HMMPfam hit to PF01048, Phosphorylase family, score 2.2e-97 316275016388 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 316275016389 TrkA-N domain; Region: TrkA_N; pfam02254 316275016390 TrkA-C domain; Region: TrkA_C; pfam02080 316275016391 HMMPfam hit to PF02254, TrkA-N domain, score 2.2e-41 316275016392 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016393 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 316275016394 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 316275016396 HMMPfam hit to PF02386, Cation transport protein,score 1.2e-104 316275016397 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316275016398 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316275016399 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 9.4e-65 316275016400 PS01246 Uncharacterized protein family UPF0003 signature. 316275016402 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 316275016404 HMMPfam hit to PF01292, Cytochrome b561 family,score 3.6e-34 316275016405 Cytochrome C' Region: Cytochrom_C_2; pfam01322 316275016406 HMMPfam hit to PF01322, Cytochrome C', score 3.1e-29 316275016407 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016408 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686 316275016409 nudix motif; other site 316275016410 HMMPfam hit to PF00293, NUDIX domain, score 5.1e-12 316275016411 PS00893 mutT domain signature. 316275016412 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 316275016413 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275016414 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275016415 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275016416 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5E0G6 (108 aa) fasta scores: E()=2.7e-23, 75.000% id in 84 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275016418 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 316275016419 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 316275016420 active site 316275016421 catalytic tetrad [active] 316275016422 HMMPfam hit to PF00248, Aldo/keto reductase family,score 5.5e-48 316275016423 PS00062 Aldo/keto reductase family signature 2. 316275016424 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 316275016425 active site 316275016426 substrate binding pocket [chemical binding]; other site 316275016427 dimer interface [polypeptide binding]; other site 316275016428 HMMPfam hit to PF01979, Amidohydrolase family,score 1.1e-60 316275016429 PS00483 Dihydroorotase signature 2. 316275016430 PS00482 Dihydroorotase signature 1. 316275016431 Domain of unknown function; Region: DUF331; cl01149 316275016432 HMMPfam hit to PF03889, Domain of unknown function,score 6.4e-22 316275016433 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275016434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275016435 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275016436 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275016437 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275016438 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275016439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275016440 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 316275016441 DNA binding site [nucleotide binding] 316275016443 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 9.6e-12 316275016444 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 316275016445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316275016446 Walker A/P-loop; other site 316275016447 ATP binding site [chemical binding]; other site 316275016448 Q-loop/lid; other site 316275016449 ABC transporter signature motif; other site 316275016450 Walker B; other site 316275016451 D-loop; other site 316275016452 H-loop/switch region; other site 316275016453 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316275016454 HMMPfam hit to PF00005, ABC transporter, score 7.1e-53 316275016455 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016456 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 316275016457 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 316275016458 Walker A/P-loop; other site 316275016459 ATP binding site [chemical binding]; other site 316275016460 Q-loop/lid; other site 316275016461 ABC transporter signature motif; other site 316275016462 Walker B; other site 316275016463 D-loop; other site 316275016464 H-loop/switch region; other site 316275016465 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 316275016466 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 1.6e-25 316275016467 HMMPfam hit to PF00005, ABC transporter, score 3.2e-52 316275016468 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016469 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 316275016470 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 316275016471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275016472 dimer interface [polypeptide binding]; other site 316275016473 conserved gate region; other site 316275016474 putative PBP binding loops; other site 316275016475 ABC-ATPase subunit interface; other site 316275016476 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.5e-36 316275016478 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 316275016479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275016480 dimer interface [polypeptide binding]; other site 316275016481 conserved gate region; other site 316275016482 putative PBP binding loops; other site 316275016483 ABC-ATPase subunit interface; other site 316275016484 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-57 316275016486 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 316275016487 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 316275016488 peptide binding site [polypeptide binding]; other site 316275016489 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 2.7e-71 316275016490 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 316275016491 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275016492 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 316275016493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275016494 Walker A motif; other site 316275016495 ATP binding site [chemical binding]; other site 316275016496 Walker B motif; other site 316275016497 arginine finger; other site 316275016498 HMMPfam hit to PF02954, Bacterial regulatory protein, Fis fam, score 7.1e-05 316275016499 Predicted helix-turn-helix motif with score 1367.000, SD 3.84 at aa 311-332, sequence FHQRKAAELLGITYHQFRGLLK 316275016500 PS00688 Sigma-54 interaction domain C-terminal part signature. 316275016501 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 6.4e-117 316275016502 HMMPfam hit to PF07728, ATPase family associated with various, score 0.00016 316275016503 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275016504 phage shock protein A; Region: phageshock_pspA; TIGR02977 316275016505 HMMPfam hit to PF04012, PspA/IM30 family, score 4.4e-63 316275016506 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016507 phage shock protein B; Provisional; Region: pspB; PRK09458 316275016508 HMMPfam hit to PF06667, Phage shock protein B,score 2.2e-42 316275016510 PspC domain; Region: PspC; cl00864 316275016511 phage shock protein C; Region: phageshock_pspC; TIGR02978 316275016512 HMMPfam hit to PF04024, PspC domain, score 7e-25 316275016514 YcjX-like family, DUF463; Region: DUF463; pfam04317 316275016515 HMMPfam hit to PF04317, YcjX-like family, DUF463,score 8.7e-282 316275016516 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016517 hypothetical protein; Provisional; Region: PRK05415 316275016518 Domain of unknown function (DUF697); Region: DUF697; cl12064 316275016519 HMMPfam hit to PF05128, Family of unknown function (DUF697), score 7.4e-87 316275016521 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 316275016522 dimer interface [polypeptide binding]; other site 316275016523 substrate binding site [chemical binding]; other site 316275016524 ATP binding site [chemical binding]; other site 316275016525 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase, score 8.1e-146 316275016526 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 316275016527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275016528 Walker A/P-loop; other site 316275016529 ATP binding site [chemical binding]; other site 316275016530 Q-loop/lid; other site 316275016531 ABC transporter signature motif; other site 316275016532 Walker B; other site 316275016533 D-loop; other site 316275016534 H-loop/switch region; other site 316275016535 HMMPfam hit to PF00005, ABC transporter, score 1.5e-50 316275016536 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016537 PS00211 ABC transporters family signature. 316275016538 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 316275016539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275016540 dimer interface [polypeptide binding]; other site 316275016541 conserved gate region; other site 316275016542 putative PBP binding loops; other site 316275016543 ABC-ATPase subunit interface; other site 316275016545 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.2e-38 316275016546 NMT1/THI5 like; Region: NMT1; pfam09084 316275016547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 316275016548 substrate binding pocket [chemical binding]; other site 316275016549 membrane-bound complex binding site; other site 316275016550 hinge residues; other site 316275016551 Putative transcription activator [Transcription]; Region: TenA; COG0819 316275016552 HMMPfam hit to PF03070, TENA/THI-4/PQQC family,score 2.1e-44 316275016553 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 316275016554 substrate binding site [chemical binding]; other site 316275016555 multimerization interface [polypeptide binding]; other site 316275016556 ATP binding site [chemical binding]; other site 316275016557 HMMPfam hit to PF02110, Hydroxyethylthiazole kinase family, score 1.2e-92 316275016558 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 316275016559 thiamine phosphate binding site [chemical binding]; other site 316275016560 active site 316275016561 pyrophosphate binding site [ion binding]; other site 316275016562 HMMPfam hit to PF02581, Thiamine monophosphate synthase/TENI, score 3.5e-84 316275016563 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275016564 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275016565 metal binding site [ion binding]; metal-binding site 316275016566 active site 316275016567 I-site; other site 316275016568 HMMPfam hit to PF00990, GGDEF domain, score 3.9e-11 316275016570 Similar to N-terminal part of Pseudoalteromonas haloplanktis Hypothetical protein UniProt:Q3IG16 (1007 aa) fasta scores: E()=1.6e-19, 26.062% id in 353 aa. CDS appears to be truncated by the insertion of the downstream IS element and subsequent recombination events 316275016572 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275016573 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275016574 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275016575 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 316275016576 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 316275016577 HMMPfam hit to PF01571, Glycine cleavage T-protein (aminomethyl tran, score 6.8e-112 316275016578 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 316275016579 putative active site [active] 316275016580 putative catalytic site [active] 316275016581 HMMPfam hit to PF01575, MaoC like domain, score 1.3e-20 316275016582 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 316275016583 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 316275016584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275016585 active site 316275016586 phosphorylation site [posttranslational modification] 316275016587 intermolecular recognition site; other site 316275016588 dimerization interface [polypeptide binding]; other site 316275016589 HMMPfam hit to PF00072, Response regulator receiver domain, score 4.7e-16 316275016590 HMMPfam hit to PF01584, CheW-like domain, score 3.5e-28 316275016591 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 316275016592 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 316275016593 HMMPfam hit to PF00639, PPIC-type PPIASE domain,score 4.8e-32 316275016594 inosine/guanosine kinase; Provisional; Region: PRK15074 316275016595 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 316275016596 substrate binding site [chemical binding]; other site 316275016597 ATP binding site [chemical binding]; other site 316275016598 HMMPfam hit to PF00294, pfkB family carbohydrate kinase, score 1.1e-07 316275016599 PS00584 pfkB family of carbohydrate kinases signature 2. 316275016600 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 316275016601 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 316275016602 active site 316275016603 HMMPfam hit to PF00478, IMP dehydrogenase / GMP reductase domain, score 3.3e-157 316275016604 PS00487 IMP dehydrogenase / GMP reductase signature. 316275016605 Similar to N-terminal part of Vibrio phage K139 Int UniProt:Q9T205 (345 aa) fasta scores: E()=6.5e-39, 42.292% id in 253 aa. The CDS appears to be truncated at the C-terminus. The sequence has been checked and is believed to be correct 316275016606 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 316275016607 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316275016608 cofactor binding site; other site 316275016609 DNA binding site [nucleotide binding] 316275016610 substrate interaction site [chemical binding]; other site 316275016611 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 316275016612 HMMPfam hit to PF00145, C-5 cytosine-specific DNA methylase, score 2.5e-61 316275016613 PS00094 C-5 cytosine-specific DNA methylases active site. 316275016614 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 316275016615 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 316275016616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275016617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275016618 ATP binding site [chemical binding]; other site 316275016619 Mg2+ binding site [ion binding]; other site 316275016620 G-X-G motif; other site 316275016621 PS00059 Zinc-containing alcohol dehydrogenases signature. 316275016622 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.5e-06 316275016623 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 316275016624 Catalytic site [active] 316275016625 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 316275016626 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 316275016627 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 316275016628 E-class dimer interface [polypeptide binding]; other site 316275016629 P-class dimer interface [polypeptide binding]; other site 316275016630 active site 316275016631 Cu2+ binding site [ion binding]; other site 316275016632 Zn2+ binding site [ion binding]; other site 316275016633 HMMPfam hit to PF00080, Copper/zinc superoxide dismutase (SODC), score 7.2e-44 316275016634 PS00087 Copper/Zinc superoxide dismutase signature 1. 316275016635 Domain of unknown function DUF302; Region: DUF302; pfam03625 316275016636 HMMPfam hit to PF03625, Domain of unknown function DUF302, score 1e-11 316275016637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275016638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275016639 metal binding site [ion binding]; metal-binding site 316275016640 active site 316275016641 I-site; other site 316275016643 HMMPfam hit to PF00990, GGDEF domain, score 1.3e-43 316275016644 HMMPfam hit to PF00881, Nitroreductase family,score 6.5e-62 316275016645 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275016646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275016647 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275016648 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275016649 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275016650 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275016651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275016652 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 316275016653 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 316275016654 putative acyl-acceptor binding pocket; other site 316275016655 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 1.6e-78 316275016657 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275016658 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275016659 Integrase core domain; Region: rve; pfam00665 316275016660 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 24-45, sequence ISAREIGQKLKRSNGSISKELR 316275016661 HMMPfam hit to PF00665, Integrase core domain,score 1.1e-31 316275016662 transketolase; Reviewed; Region: PRK12753 316275016663 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 316275016664 TPP-binding site [chemical binding]; other site 316275016665 dimer interface [polypeptide binding]; other site 316275016666 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 316275016667 PYR/PP interface [polypeptide binding]; other site 316275016668 dimer interface [polypeptide binding]; other site 316275016669 TPP binding site [chemical binding]; other site 316275016670 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 316275016671 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 2.4e-12 316275016672 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 4.9e-65 316275016673 PS00802 Transketolase signature 2. 316275016674 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 2.3e-237 316275016675 PS00801 Transketolase signature 1. 316275016676 transaldolase-like protein; Provisional; Region: PTZ00411 316275016677 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 316275016678 active site 316275016679 dimer interface [polypeptide binding]; other site 316275016680 catalytic residue [active] 316275016681 HMMPfam hit to PF00923, Transaldolase, score 5e-169 316275016682 PS00958 Transaldolase active site. 316275016683 PS01054 Transaldolase signature 1. 316275016684 Oxygen tolerance; Region: BatD; pfam13584 316275016686 von Willebrand factor type A domain; Region: VWA_2; pfam13519 316275016687 metal ion-dependent adhesion site (MIDAS); other site 316275016688 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 316275016689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275016690 TPR motif; other site 316275016691 binding surface 316275016692 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0001 316275016694 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 316275016695 metal ion-dependent adhesion site (MIDAS); other site 316275016697 HMMPfam hit to PF00092, von Willebrand factor type A domain, score 4.9e-26 316275016698 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 316275016700 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 316275016701 Protein of unknown function DUF58; Region: DUF58; pfam01882 316275016702 HMMPfam hit to PF01882, Protein of unknown function DUF58, score 0.00049 316275016703 MoxR-like ATPases [General function prediction only]; Region: COG0714 316275016704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275016705 Walker A motif; other site 316275016706 ATP binding site [chemical binding]; other site 316275016707 Walker B motif; other site 316275016708 arginine finger; other site 316275016709 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 3.1e-06 316275016710 HMMPfam hit to PF07726, ATPase family associated with various cellul, score 1e-82 316275016711 Similar to Vibrio cholerae Hemolysin secretion protein precursor HlyB UniProt:P15492 (548 aa) fasta scores: E()=1.3e-26, 45.6% id in 237 aa. CDS contains a frameshift after codon 30 316275016712 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.6e-58 316275016713 Protein of unknown function (DUF445); Region: DUF445; pfam04286 316275016715 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 316275016716 CoenzymeA binding site [chemical binding]; other site 316275016717 subunit interaction site [polypeptide binding]; other site 316275016718 PHB binding site; other site 316275016719 HMMPfam hit to PF03061, Thioesterase superfamily,score 3e-18 316275016720 HDOD domain; Region: HDOD; pfam08668 316275016721 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016723 integron integrase; Region: integrase_gron; TIGR02249 316275016724 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275016725 active site 316275016726 DNA binding site [nucleotide binding] 316275016727 Int/Topo IB signature motif; other site 316275016728 HMMPfam hit to PF00589, Phage integrase family,score 1.4e-34 316275016729 Similar to Alkaliphilus metalliredigens Putative transposase UniProt:A6TTH3 (394 aa) fasta scores: E()=2.2e-55, 36.1% id in 51 aa. CDS contains a translational stop codon after codon 106 316275016731 RES domain; Region: RES; pfam08808 316275016732 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 316275016733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275016734 Coenzyme A binding pocket [chemical binding]; other site 316275016735 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.8e-11 316275016736 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 316275016737 PS00430 TonB-dependent receptor proteins signature 1. 316275016738 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316275016739 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 316275016740 HMMPfam hit to PF02604, Phd_YefM, score 3.6e-13 316275016741 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 316275016742 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 1.7e-18 316275016743 Cupin domain; Region: Cupin_2; pfam07883 316275016744 HMMPfam hit to PF07883, Cupin domain, score 2.9e-12 316275016745 Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547 316275016746 Fic/DOC family; Region: Fic; cl00960 316275016747 HMMPfam hit to PF02661, Fic protein family, score 1e-25 316275016748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 316275016749 HMMPfam hit to PF05016, Plasmid stabilisation system protein, score 1.1e-08 316275016750 RelB antitoxin; Region: RelB; pfam04221 316275016751 HMMPfam hit to PF04221, RelB antitoxin, score 1e-35 316275016752 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 316275016753 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 316275016754 putative active site [active] 316275016755 putative NTP binding site [chemical binding]; other site 316275016756 putative nucleic acid binding site [nucleotide binding]; other site 316275016757 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 316275016758 GIY-YIG motif/motif A; other site 316275016759 putative active site [active] 316275016760 putative metal binding site [ion binding]; other site 316275016761 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 316275016762 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 316275016763 HMMPfam hit to PF02604, Phd_YefM, score 3.2e-23 316275016764 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 316275016765 HMMPfam hit to PF06769, Plasmid encoded toxin Txe,score 1.2e-60 316275016766 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275016767 Putative transposase; Region: Y2_Tnp; pfam04986 316275016768 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 316275016769 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 316275016770 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 316275016771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 316275016772 Transposase; Region: HTH_Tnp_1; pfam01527 316275016773 HMMPfam hit to PF01527, Transposase, score 2.3e-15 316275016774 Predicted helix-turn-helix motif with score 1896.000, SD 5.64 at aa 26-47, sequence YSITEASQAMNVSKSAMTNWVQ 316275016775 PS00044 Bacterial regulatory proteins, lysR family signature. 316275016776 putative transposase OrfB; Reviewed; Region: PHA02517 316275016777 HTH-like domain; Region: HTH_21; pfam13276 316275016778 Integrase core domain; Region: rve; pfam00665 316275016779 Integrase core domain; Region: rve_3; pfam13683 316275016780 HMMPfam hit to PF00665, Integrase core domain,score 1.3e-36 316275016781 Similar to C-terminal part of Geobacillus kaustophilus Transposase UniProt:Q5L3N6 (287 aa) fasta scores: E()=9.1e-10, 55.385% id in 65 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275016782 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 316275016783 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 316275016784 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275016785 ATP binding site [chemical binding]; other site 316275016786 Mg++ binding site [ion binding]; other site 316275016787 motif III; other site 316275016788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275016789 nucleotide binding region [chemical binding]; other site 316275016790 ATP-binding site [chemical binding]; other site 316275016791 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 8.1e-60 316275016792 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016793 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275016794 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.1e-32 316275016795 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 316275016796 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 316275016797 HMMPfam hit to PF01098, Cell cycle protein, score 5.9e-110 316275016800 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316275016801 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316275016802 active site 316275016803 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1.2e-38 316275016804 PS01129 Rlu family of pseudouridine synthase signature. 316275016805 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 316275016806 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 316275016807 active site 316275016808 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.9e-42 316275016809 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 316275016810 RNA recognition motif; Region: RRM; smart00360 316275016811 HMMPfam hit to PF00076, RNA recognition motif. (a.k.a. RRM, RBD, or, score 1.9e-21 316275016812 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 316275016813 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 316275016814 trimer interface [polypeptide binding]; other site 316275016815 eyelet of channel; other site 316275016816 HMMPfam hit to PF00267, Gram-negative porin, score 1.5e-07 316275016817 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 316275016818 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 316275016819 HMMPfam hit to PF03702, Uncharacterised protein family (UPF0075), score 3.8e-213 316275016820 beta-hexosaminidase; Provisional; Region: PRK05337 316275016821 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 316275016822 HMMPfam hit to PF00933, Glycosyl hydrolase family 3 N terminal, score 2.3e-66 316275016823 PS00775 Glycosyl hydrolases family 3 active site. 316275016824 trehalose repressor; Provisional; Region: treR; PRK09492 316275016825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275016826 DNA binding site [nucleotide binding] 316275016827 domain linker motif; other site 316275016828 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 316275016829 dimerization interface [polypeptide binding]; other site 316275016830 ligand binding site [chemical binding]; other site 316275016831 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 2e-10 316275016832 Predicted helix-turn-helix motif with score 1931.000, SD 5.76 at aa 10-31, sequence LTILDVAKLAGVGKSTVSRVLT 316275016833 PS00356 Bacterial regulatory proteins, lacI family signature. 316275016834 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 0.00024 316275016835 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016836 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 316275016837 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 316275016838 active site turn [active] 316275016839 phosphorylation site [posttranslational modification] 316275016840 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 316275016841 HMMPfam hit to PF00367, phosphotransferase system,EIIB, score 1.1e-13 316275016842 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 316275016843 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 1.3e-29 316275016845 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 316275016846 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 316275016847 Ca binding site [ion binding]; other site 316275016848 active site 316275016849 catalytic site [active] 316275016850 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 1.5e-132 316275016851 pyruvate kinase; Provisional; Region: PRK05826 316275016852 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 316275016853 domain interfaces; other site 316275016854 active site 316275016855 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 2.2e-47 316275016856 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 2e-195 316275016857 PS00110 Pyruvate kinase active site signature. 316275016858 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 316275016859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275016860 FeS/SAM binding site; other site 316275016861 HMMPfam hit to PF04055, Radical SAM superfamily,score 0.0041 316275016862 MarR family; Region: MarR_2; cl17246 316275016863 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 316275016864 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 316275016865 Predicted helix-turn-helix motif with score 1136.000, SD 3.06 at aa 42-63, sequence ISRIELSKESHLAPASITKITR 316275016866 HMMPfam hit to PF00480, ROK family, score 8e-53 316275016867 PS01125 ROK family signature. 316275016868 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 316275016869 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 316275016870 tetramer interface [polypeptide binding]; other site 316275016871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275016872 catalytic residue [active] 316275016873 HMMPfam hit to PF01212, Beta-eliminating lyase,score 2.3e-149 316275016874 HMMPfam hit to PF00202, Aminotransferase class-III,score 0.05 316275016875 regulatory ATPase RavA; Provisional; Region: PRK13531 316275016876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275016877 Walker A motif; other site 316275016878 ATP binding site [chemical binding]; other site 316275016879 Walker B motif; other site 316275016880 arginine finger; other site 316275016881 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 316275016882 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.5e-43 316275016883 hypothetical protein; Provisional; Region: yieM; PRK10997 316275016884 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 316275016885 metal ion-dependent adhesion site (MIDAS); other site 316275016886 Protein of unknown function (DUF2960); Region: DUF2960; pfam11173 316275016887 Protein of unknown function (DUF3069); Region: DUF3069; pfam11269 316275016888 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316275016889 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275016890 ligand binding site [chemical binding]; other site 316275016891 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275016892 HMMPfam hit to PF00691, OmpA family, score 4.9e-12 316275016893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 316275016894 CreA protein; Region: CreA; pfam05981 316275016895 HMMPfam hit to PF05981, CreA protein, score 1.5e-68 316275016896 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275016897 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 316275016898 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 316275016899 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 316275016900 Zn2+ binding site [ion binding]; other site 316275016901 Mg2+ binding site [ion binding]; other site 316275016903 HMMPfam hit to PF01966, HD domain, score 1.6e-18 316275016904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 316275016906 HMMPfam hit to PF07670, Nucleoside recognition,score 2.3e-14 316275016907 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 316275016908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275016909 Walker A/P-loop; other site 316275016910 ATP binding site [chemical binding]; other site 316275016911 Q-loop/lid; other site 316275016912 ABC transporter signature motif; other site 316275016913 Walker B; other site 316275016914 D-loop; other site 316275016915 H-loop/switch region; other site 316275016916 PS00017 ATP/GTP-binding site motif A (P-loop). 316275016918 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0002 316275016919 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275016920 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 316275016921 putative substrate translocation pore; other site 316275016923 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 5.7e-41 316275016924 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 316275016927 Response regulator receiver domain; Region: Response_reg; pfam00072 316275016928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275016929 active site 316275016930 phosphorylation site [posttranslational modification] 316275016931 intermolecular recognition site; other site 316275016932 dimerization interface [polypeptide binding]; other site 316275016933 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 316275016934 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-22 316275016935 PAS domain; Region: PAS; smart00091 316275016936 PAS fold; Region: PAS; pfam00989 316275016937 hypothetical protein; Provisional; Region: PRK05423 316275016938 HMMPfam hit to PF04363, Protein of unknown function (DUF496), score 4.3e-52 316275016939 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 316275016940 HMMPfam hit to PF04519, Protein of unknown function, DUF583, score 3.2e-16 316275016941 hypothetical protein; Provisional; Region: PRK11239 316275016942 Protein of unknown function, DUF480; Region: DUF480; cl01209 316275016943 HMMPfam hit to PF04337, Protein of unknown function, DUF480, score 6.1e-88 316275016944 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 316275016945 GIY-YIG motif/motif A; other site 316275016946 putative active site [active] 316275016947 putative metal binding site [ion binding]; other site 316275016948 HMMPfam hit to PF01541, GIY-YIG catalytic domain,score 2e-15 316275016949 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 316275016950 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 316275016951 homodimer interface [polypeptide binding]; other site 316275016952 NAD binding pocket [chemical binding]; other site 316275016953 ATP binding pocket [chemical binding]; other site 316275016954 Mg binding site [ion binding]; other site 316275016955 active-site loop [active] 316275016956 HMMPfam hit to PF02540, NAD synthase, score 8.1e-83 316275016957 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 316275016958 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 316275016959 active site 316275016960 (T/H)XGH motif; other site 316275016961 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.7e-05 316275016962 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 316275016963 HMMPfam hit to PF02311, AraC-like ligand binding domain, score 0.0012 316275016964 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 316275016965 putative acyl-acceptor binding pocket; other site 316275016966 Similar to Vibrio fischeri Transcriptional regulator, LysR family UniProt:Q5DZX9 (311 aa) fasta scores: E()=4.1e-109, 89.251% id in 307 aa. CDS contains a frameshift after codon 91. The sequence has been checked and is believed to be correct 316275016967 HMMPfam hit to PF03466, LysR substrate binding domain, score 8.4e-29 316275016968 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 4.3e-17 316275016969 Predicted helix-turn-helix motif with score 2138.000, SD 6.47 at aa 18-39, sequence LNFTRAAEKLGISKSHVSKQIK 316275016971 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316275016972 DNA-binding site [nucleotide binding]; DNA binding site 316275016973 RNA-binding motif; other site 316275016974 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 2.6e-41 316275016975 PS00352 'Cold-shock' DNA-binding domain signature. 316275016976 Protein of unknown function (DUF406); Region: DUF406; pfam04175 316275016977 HMMPfam hit to PF04175, Protein of unknown function (DUF406), score 8.8e-24 316275016978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 316275016979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 316275016980 Predicted helix-turn-helix motif with score 1599.000, SD 4.63 at aa 32-53, sequence MSYTTLSQQTGVSRTGISHHFP 316275016981 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature. 316275016982 Similar to Vibrio vulnificus Outer membrane protein UniProt:Q8D9B5 (469 aa) fasta scores: E()=1.2e-98, 61.028% id in 467 aa. CDS contains a frameshift after codon 45. The sequence has been checked and is believed to be correct 316275016983 HMMPfam hit to PF02321, Outer membrane efflux protein, score 1.1e-09 316275016984 HMMPfam hit to PF02321, Outer membrane efflux protein, score 7e-08 316275016985 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 316275016986 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275016987 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275016989 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.0019 316275016990 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316275016991 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316275016992 ABC-2 type transporter; Region: ABC2_membrane; cl17235 316275016994 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 316275016996 HMMPfam hit to PF01061, ABC-2 type transporter,score 0.017 316275016997 putative outer membrane lipoprotein; Provisional; Region: PRK09967 316275016998 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275016999 ligand binding site [chemical binding]; other site 316275017000 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275017001 HMMPfam hit to PF00691, OmpA family, score 1.1e-30 316275017002 Transcriptional activator HlyU; Region: HlyU; pfam10115 316275017003 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 316275017004 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 316275017005 ligand binding site [chemical binding]; other site 316275017006 homodimer interface [polypeptide binding]; other site 316275017007 NAD(P) binding site [chemical binding]; other site 316275017008 trimer interface B [polypeptide binding]; other site 316275017009 trimer interface A [polypeptide binding]; other site 316275017010 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 316275017011 HMMPfam hit to PF05222, Alanine dehydrogenase/PNT,N-terminal dom, score 7.9e-67 316275017012 HMMPfam hit to PF01262, Alanine dehydrogenase/PNT,C-terminal dom, score 1.1e-83 316275017014 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 316275017015 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 316275017016 HMMPfam hit to PF02233, NAD(P) transhydrogenase beta subunit, score 0 316275017019 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 316275017020 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 316275017021 PhnA protein; Region: PhnA; pfam03831 316275017022 HMMPfam hit to PF03831, PhnA protein, score 2.8e-17 316275017023 HMMPfam hit to PF08274, PhnA Zinc-Ribbon, score 2.7e-15 316275017024 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 316275017025 HMMPfam hit to PF05721, Phytanoyl-CoA dioxygenase (PhyH), score 0.00027 316275017026 RDD family; Region: RDD; pfam06271 316275017027 HMMPfam hit to PF06271, RDD family, score 9.3e-32 316275017029 Similar to C-terminal part of Nitrosomonas eutropha Hypothetical protein UniProt:Q3N8F6 (157 aa) fasta scores: E()=8, 44.444% id in 36 aa. CDS appears to be truncated by the insertion of the upstream bacteriophage and subsequent recombination events 316275017030 DNA replication initiation protein; Region: PHA00202 316275017031 Replication initiation factor; Region: Rep_trans; pfam02486 316275017032 HMMPfam hit to PF02486, Replication initiation factor, score 4.1e-42 316275017033 Similar to C-terminal part of Bacteriophage VfO4K68 vpf119 UniProt:Q9MBX6 (119 aa) fasta scores: E()=0.00043,51.064% id in 47 aa. The CDS appears to be truncated at the N-terminus 316275017035 DNA replication initiation protein; Region: PHA00202 316275017036 Replication initiation factor; Region: Rep_trans; pfam02486 316275017037 HMMPfam hit to PF02486, Replication initiation factor, score 4.1e-42 316275017038 Similar to C-terminal part of Vibrio phage vf12 Vpf117 UniProt:O88148 (117 aa) fasta scores: E()=3.7e-17,57.955% id in 88 aa. The CDS appears to be truncated at the N-terminus 316275017039 HMMPfam hit to PF06950, Protein of unknown function (DUF1293), score 1.2e-19 316275017040 translation initiation factor Sui1; Validated; Region: PRK06824 316275017041 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 316275017042 putative rRNA binding site [nucleotide binding]; other site 316275017043 HMMPfam hit to PF01253, Translation initiation factor SUI1, score 1.4e-33 316275017044 Protein of unknown function (DUF3319); Region: DUF3319; pfam11782 316275017045 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 316275017046 active site 316275017047 DNA binding site [nucleotide binding] 316275017048 Int/Topo IB signature motif; other site 316275017049 HMMPfam hit to PF00589, Phage integrase family,score 2.5e-05 316275017050 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 316275017051 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 316275017052 ATP-grasp domain; Region: ATP-grasp_4; cl17255 316275017053 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 1.8e-47 316275017054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 316275017055 Sporulation related domain; Region: SPOR; pfam05036 316275017056 HMMPfam hit to PF05036, Sporulation related domain,score 4.7e-17 316275017057 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275017058 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 316275017059 CoA binding domain; Region: CoA_binding_2; pfam13380 316275017060 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 316275017061 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 316275017062 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 316275017063 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 316275017064 HMMPfam hit to PF02629, CoA binding domain, score 0.00018 316275017065 PS00024 Hemopexin domain signature. 316275017066 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 9.7e-09 316275017067 Similar to Vibrio fischeri Sensory box/GGDEF family protein UniProt:Q5E009 (654 aa) fasta scores: E()=7.3e-155, 62.730% id in 652 aa. CDS is disrupted by the insertion of an IS element after codon 140 316275017068 HMMPfam hit to PF00990, GGDEF domain, score 3.9e-56 316275017069 HMMPfam hit to PF00672, HAMP domain, score 3.2e-10 316275017071 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275017072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275017073 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275017075 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 316275017076 MPT binding site; other site 316275017077 trimer interface [polypeptide binding]; other site 316275017078 HMMPfam hit to PF00994, Probable molybdopterin binding domain, score 1.6e-35 316275017079 PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 316275017080 Weakly similar to Salmonella typhimurium TraF protein UniProt:Q79VS9 (400 aa) fasta scores: E()=3.4e-05,27.400% id in 427 aa. CDS contains a frameshift after codon 287. The sequence has been checked and is believed to be correct 316275017081 hypothetical protein; Provisional; Region: PRK05114 316275017082 HMMPfam hit to PF03701, Uncharacterised protein family (UPF0181), score 1.5e-20 316275017083 Protein of unknown function (DUF2861); Region: DUF2861; pfam11060 316275017084 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316275017085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275017086 active site 316275017087 phosphorylation site [posttranslational modification] 316275017088 intermolecular recognition site; other site 316275017089 dimerization interface [polypeptide binding]; other site 316275017090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275017091 DNA binding site [nucleotide binding] 316275017092 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 9e-23 316275017093 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-06 316275017094 Domain of unknown function (DUF3404); Region: DUF3404; pfam11884 316275017095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 316275017096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275017097 dimer interface [polypeptide binding]; other site 316275017098 phosphorylation site [posttranslational modification] 316275017099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275017100 ATP binding site [chemical binding]; other site 316275017101 Mg2+ binding site [ion binding]; other site 316275017102 G-X-G motif; other site 316275017103 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 2.8e-10 316275017104 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.00024 316275017106 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 316275017107 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 316275017108 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 316275017109 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 316275017110 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.5e-20 316275017111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275017112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275017113 Predicted helix-turn-helix motif with score 1743.000, SD 5.12 at aa 179-200, sequence LTIDAVAPKLGMSASTLKRKLQ 316275017114 PS00041 Bacterial regulatory proteins, araC family signature. 316275017115 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.3e-08 316275017116 Similar to Vibrio fischeri Phosphate-binding protein UniProt:Q5E021 (270 aa) fasta scores: E()=1.3e-67,69.853% id in 272 aa. CDS contains a frameshift after codon 182. The sequence has been checked and is believed to be correct 316275017117 Protein of unknown function (DUF1255); Region: DUF1255; cl01202 316275017118 HMMPfam hit to PF06865, Protein of unknown function (DUF1255), score 1.2e-43 316275017119 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 316275017120 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 316275017121 ATP binding site [chemical binding]; other site 316275017122 Mg++ binding site [ion binding]; other site 316275017123 motif III; other site 316275017124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275017125 nucleotide binding region [chemical binding]; other site 316275017126 ATP-binding site [chemical binding]; other site 316275017127 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 3.1e-32 316275017128 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 3.5e-62 316275017129 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 316275017130 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 316275017131 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316275017132 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275017133 ligand binding site [chemical binding]; other site 316275017134 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275017135 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 316275017136 ligand binding site [chemical binding]; other site 316275017137 HMMPfam hit to PF00691, OmpA family, score 2.7e-09 316275017138 HMMPfam hit to PF00691, OmpA family, score 1.1e-15 316275017139 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275017140 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 316275017141 HMMPfam hit to PF01345, Domain of unknown function DUF11, score 7.3e-06 316275017142 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275017143 HMMPfam hit to PF00563, EAL domain, score 3.9e-14 316275017144 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275017145 EamA-like transporter family; Region: EamA; pfam00892 316275017147 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 3.9e-17 316275017148 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 8.2e-11 316275017149 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 316275017150 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 316275017151 active site 316275017152 intersubunit interface [polypeptide binding]; other site 316275017153 catalytic residue [active] 316275017154 HMMPfam hit to PF01081, KDPG and KHG aldolase,score 1.3e-99 316275017155 PS00160 KDPG and KHG aldolases Schiff-base forming residue. 316275017156 PS00159 KDPG and KHG aldolases active site. 316275017157 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 316275017158 fructuronate transporter; Provisional; Region: PRK10034; cl15264 316275017160 HMMPfam hit to PF02447, GntP family permease, score 4e-128 316275017161 HMMPfam hit to PF03600, Citrate transporter, score 2.8e-05 316275017162 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 316275017163 AAA domain; Region: AAA_18; pfam13238 316275017164 ATP-binding site [chemical binding]; other site 316275017165 Gluconate-6-phosphate binding site [chemical binding]; other site 316275017166 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017167 HMMPfam hit to PF01202, Shikimate kinase, score 6.3e-08 316275017168 phosphogluconate dehydratase; Validated; Region: PRK09054 316275017169 6-phosphogluconate dehydratase; Region: edd; TIGR01196 316275017170 HMMPfam hit to PF00920, Dehydratase family, score 1.3e-227 316275017171 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 316275017172 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 316275017173 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 316275017174 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 316275017175 DNA binding site [nucleotide binding] 316275017176 domain linker motif; other site 316275017177 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 316275017178 putative ligand binding site [chemical binding]; other site 316275017179 putative dimerization interface [polypeptide binding]; other site 316275017180 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.3e-10 316275017181 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI fami, score 1.7e-08 316275017182 Predicted helix-turn-helix motif with score 2127.000, SD 6.43 at aa 12-33, sequence PTLQDIADRVGVTKMTVSRFIR 316275017183 PS00356 Bacterial regulatory proteins, lacI family signature. 316275017184 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 316275017185 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 316275017186 GTP/Mg2+ binding site [chemical binding]; other site 316275017187 G4 box; other site 316275017188 G5 box; other site 316275017189 G1 box; other site 316275017190 Switch I region; other site 316275017191 G2 box; other site 316275017192 G3 box; other site 316275017193 Switch II region; other site 316275017194 HMMPfam hit to PF01926, GTPase of unknown function,score 1.2e-16 316275017195 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017196 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 316275017197 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 316275017198 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 316275017199 HMMPfam hit to PF07683, Cobalamin synthesis protein cobW C-terminal, score 6.7e-05 316275017200 HMMPfam hit to PF02492, CobW/HypB/UreG,nucleotide-binding domain, score 1.6e-47 316275017201 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 316275017203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316275017204 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 316275017205 Walker A/P-loop; other site 316275017206 ATP binding site [chemical binding]; other site 316275017207 Q-loop/lid; other site 316275017208 ABC transporter signature motif; other site 316275017209 Walker B; other site 316275017210 D-loop; other site 316275017211 H-loop/switch region; other site 316275017213 HMMPfam hit to PF00005, ABC transporter, score 9.6e-60 316275017214 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017215 PS00211 ABC transporters family signature. 316275017216 Protein of unknown function (DUF3233); Region: DUF3233; pfam11557 316275017217 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 316275017218 HMMPfam hit to PF03616, Sodium/glutamate symporter,score 1.8e-214 316275017220 PS00284 Serpins signature. 316275017221 Sodium/glutamate symporter; Region: Glt_symporter; pfam03616 316275017223 HMMPfam hit to PF03616, Sodium/glutamate symporter,score 1.1e-217 316275017224 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316275017225 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275017226 dimer interface [polypeptide binding]; other site 316275017227 putative CheW interface [polypeptide binding]; other site 316275017228 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4.7e-44 316275017230 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275017231 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275017233 N-glycosyltransferase; Provisional; Region: PRK11204 316275017234 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 316275017235 DXD motif; other site 316275017236 HMMPfam hit to PF03142, Chitin synthase, score 9.4e-06 316275017238 HMMPfam hit to PF00535, Glycosyl transferase family, score 2.5e-18 316275017239 Predicted helix-turn-helix motif with score 991.000, SD 2.56 at aa 95-116, sequence FNIYSLGDSCFVTLPTASKNLK 316275017241 Weakly similar to Vibrio cholerae Toxin coregulated pilus biosynthesis protein P TcpP UniProt:P29485 (221 aa) fasta scores: E()=6.1e-05, 23.982% id in 221 aa. CDS contains a nonsense mutation (AGA or CGA to TGA) after codon 78. The sequence has been checked and is believed to be correct 316275017243 hypothetical protein; Provisional; Region: PRK11027 316275017244 HMMPfam hit to PF04219, Protein of unknown function, DUF, score 1.1e-07 316275017245 Homeodomain-like domain; Region: HTH_23; cl17451 316275017246 Winged helix-turn helix; Region: HTH_29; pfam13551 316275017247 Homeodomain-like domain; Region: HTH_32; pfam13565 316275017248 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275017249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275017250 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 316275017251 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 316275017253 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 316275017254 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 316275017255 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 316275017256 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-ter, score 1.8e-213 316275017257 PS00461 6-phosphogluconate dehydrogenase signature. 316275017258 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 1.6e-85 316275017259 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 316275017260 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 316275017261 putative active site [active] 316275017262 HMMPfam hit to PF01182, Glucosamine-6-phosphate isomerases/6-, score 0.0028 316275017263 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 316275017264 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 316275017265 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 316275017266 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, C-termina, score 3.1e-164 316275017267 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, NAD bindi, score 4.8e-103 316275017268 PS00069 Glucose-6-phosphate dehydrogenase active site. 316275017269 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 316275017270 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275017272 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275017273 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275017274 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275017275 N-glycosyltransferase; Provisional; Region: PRK11204 316275017276 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 316275017277 DXD motif; other site 316275017278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316275017279 HMMPfam hit to PF03142, Chitin synthase, score 4.1e-06 316275017281 HMMPfam hit to PF00535, Glycosyl transferase family, score 1.8e-17 316275017282 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 316275017283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316275017284 FtsX-like permease family; Region: FtsX; pfam02687 316275017285 HMMPfam hit to PF02687, Predicted permease, score 7.1e-50 316275017287 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 316275017288 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 316275017289 Walker A/P-loop; other site 316275017290 ATP binding site [chemical binding]; other site 316275017291 Q-loop/lid; other site 316275017292 ABC transporter signature motif; other site 316275017293 Walker B; other site 316275017294 D-loop; other site 316275017295 H-loop/switch region; other site 316275017296 HMMPfam hit to PF00005, ABC transporter, score 4e-64 316275017297 PS00211 ABC transporters family signature. 316275017298 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017299 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 316275017300 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 316275017301 FtsX-like permease family; Region: FtsX; pfam02687 316275017302 HMMPfam hit to PF02687, Predicted permease, score 1.4e-42 316275017304 transcription-repair coupling factor; Provisional; Region: PRK10689 316275017305 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 316275017306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 316275017307 ATP binding site [chemical binding]; other site 316275017308 putative Mg++ binding site [ion binding]; other site 316275017309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 316275017310 nucleotide binding region [chemical binding]; other site 316275017311 ATP-binding site [chemical binding]; other site 316275017312 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 316275017313 HMMPfam hit to PF02559, CarD-like/TRCF domain,score 2.7e-45 316275017314 HMMPfam hit to PF04851, Type III restriction enzyme, res subunit, score 1.1e-06 316275017315 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1.6e-41 316275017316 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017317 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2.2e-18 316275017318 HMMPfam hit to PF03461, TRCF domain, score 8.1e-47 316275017319 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 316275017320 Similar to Pseudoalteromonas haloplanktis Putative orphan protein; putative transposase UniProt:Q3IIG2 (99 aa) fasta scores: E()=0.041, 35.3% id in 51 aa. CDS contains a frameshift and a deletion of 32 amino acid residues after codon 55 316275017321 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275017322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275017323 Similar to Shewanella sp. Transposase IS66 UniProt:A1RLT8 (500 aa) fasta scores: E()=1.4e-102, 51.5% id in 493 aa. CDS contains a frameshift after codon 139 316275017324 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 316275017325 catalytic residues [active] 316275017326 hinge region; other site 316275017327 alpha helical domain; other site 316275017328 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275017329 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 316275017330 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 316275017331 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 316275017333 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 4e-41 316275017334 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 316275017335 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2. 316275017336 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316275017337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275017338 S-adenosylmethionine binding site [chemical binding]; other site 316275017339 HMMPfam hit to PF08242, Methyltransferase domain,score 1.3e-06 316275017340 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 316275017341 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 316275017342 DNA-binding site [nucleotide binding]; DNA binding site 316275017343 UTRA domain; Region: UTRA; pfam07702 316275017344 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 3.2e-20 316275017345 PS00043 Bacterial regulatory proteins, gntR family signature. 316275017346 Predicted helix-turn-helix motif with score 1371.000, SD 3.86 at aa 33-54, sequence PTEIELADEFSVSRMTANKAIK 316275017347 HMMPfam hit to PF07702, UTRA domain, score 5.3e-37 316275017348 imidazolonepropionase; Validated; Region: PRK09356 316275017349 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 316275017350 active site 316275017351 HMMPfam hit to PF01979, Amidohydrolase family,score 1.5e-05 316275017352 HMMPfam hit to PF07969, Amidohydrolase family,score 7.5e-06 316275017353 formimidoylglutamase; Provisional; Region: PRK13775 316275017354 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 316275017355 putative active site [active] 316275017356 putative metal binding site [ion binding]; other site 316275017357 HMMPfam hit to PF00491, Arginase family, score 1.3e-09 316275017358 PS00147 Arginase family signature 1. 316275017359 PS00148 Arginase family signature 2. 316275017360 PS01053 Arginase family signature 3. 316275017361 urocanate hydratase; Provisional; Region: PRK05414 316275017362 HMMPfam hit to PF01175, Urocanase, score 0 316275017363 PS01233 Urocanase active site. 316275017364 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 316275017365 active sites [active] 316275017366 tetramer interface [polypeptide binding]; other site 316275017367 HMMPfam hit to PF00221, Phenylalanine and histidine ammonia-lyase, score 1.7e-226 316275017368 PS00217 Sugar transport proteins signature 2. 316275017369 PS00488 Phenylalanine and histidine ammonia-lyases signature. 316275017370 Similar to Vibrio cholerae non-o1 Multidrug efflux pump VcmN UniProt:Q4W667 (442 aa) fasta scores: E()=7.4e-95, 62.037% id in 432 aa. CDS contains a frameshift after codon 240. The sequence has been checked and is believed to be correct 316275017371 HMMPfam hit to PF01554, MatE, score 3.9e-23 316275017373 HMMPfam hit to PF01554, MatE, score 8.5e-18 316275017374 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 316275017375 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316275017376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275017377 dimerization interface [polypeptide binding]; other site 316275017378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275017379 dimer interface [polypeptide binding]; other site 316275017380 putative CheW interface [polypeptide binding]; other site 316275017382 HMMPfam hit to PF00672, HAMP domain, score 7.2e-16 316275017383 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 7.5e-56 316275017384 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 316275017385 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 316275017386 HMMPfam hit to PF00873, AcrB/AcrD/AcrF family,score 1.6e-234 316275017388 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 316275017389 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 316275017390 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275017391 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 316275017393 Outer membrane efflux protein; Region: OEP; pfam02321 316275017394 Outer membrane efflux protein; Region: OEP; pfam02321 316275017396 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 316275017397 Acyltransferase family; Region: Acyl_transf_3; pfam01757 316275017399 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316275017400 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 316275017401 NnrS protein; Region: NnrS; pfam05940 316275017402 HMMPfam hit to PF05940, NnrS protein, score 6e-165 316275017404 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 316275017405 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 316275017406 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 316275017407 active site turn [active] 316275017408 phosphorylation site [posttranslational modification] 316275017409 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 3.1e-72 316275017411 HMMPfam hit to PF00367, phosphotransferase system,EIIB, score 3.3e-16 316275017412 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 316275017413 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 316275017414 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 316275017415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275017416 active site 316275017417 phosphorylation site [posttranslational modification] 316275017418 intermolecular recognition site; other site 316275017419 dimerization interface [polypeptide binding]; other site 316275017420 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 316275017421 DNA binding site [nucleotide binding] 316275017422 HMMPfam hit to PF00072, Response regulator receiver domain, score 2.2e-33 316275017423 HMMPfam hit to PF00486, Transcriptional regulatory protein, C te, score 2.2e-17 316275017424 Similar to Vibrio fischeri Two component system histidine kinase UniProt:Q5E0E1 (449 aa) fasta scores: E()=2.5e-124, 79.118% id in 431 aa. CDS contains a frameshift after codon 245. The sequence has been checked and is believed to be correct. Possible alternative translational start 316275017426 HMMPfam hit to PF00672, HAMP domain, score 4.4e-08 316275017427 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 0.00065 316275017428 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 1.3e-25 316275017429 DNA-J related protein; Region: DNAJ_related; pfam12339 316275017430 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 316275017431 HSP70 interaction site [polypeptide binding]; other site 316275017432 HMMPfam hit to PF00226, DnaJ domain, score 4.7e-10 316275017433 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275017435 cell division protein MukB; Provisional; Region: mukB; PRK04863 316275017436 MukB N-terminal; Region: MukB; pfam04310 316275017437 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 316275017438 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017439 HMMPfam hit to PF04310, MukB N-terminal, score 2.4e-176 316275017440 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017441 condesin subunit E; Provisional; Region: PRK05256 316275017442 HMMPfam hit to PF04288, MukE-like family, score 4.7e-139 316275017443 condesin subunit F; Provisional; Region: PRK05260 316275017444 HMMPfam hit to PF03882, KicB killing factor, score 0 316275017445 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 316275017446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 316275017447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275017448 S-adenosylmethionine binding site [chemical binding]; other site 316275017449 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017450 HMMPfam hit to PF08241, Methyltransferase domain,score 3e-14 316275017451 HMMPfam hit to PF08242, Methyltransferase domain,score 4.4e-13 316275017452 PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 316275017453 Uncharacterized conserved protein [Function unknown]; Region: COG1434 316275017454 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 316275017455 putative active site [active] 316275017457 HMMPfam hit to PF02698, DUF218 domain, score 2.9e-37 316275017458 PS00120 Lipases, serine active site. 316275017459 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 316275017460 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 316275017461 Ligand binding site; other site 316275017462 oligomer interface; other site 316275017463 HMMPfam hit to PF02348, Cytidylyltransferase, score 1.3e-56 316275017464 Uncharacterized conserved protein [Function unknown]; Region: COG2835 316275017465 HMMPfam hit to PF03966, Trm112p-like protein, score 1.2e-09 316275017466 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 316275017467 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 316275017468 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 7e-108 316275017469 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 316275017470 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316275017471 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 316275017472 Walker A/P-loop; other site 316275017473 ATP binding site [chemical binding]; other site 316275017474 Q-loop/lid; other site 316275017475 ABC transporter signature motif; other site 316275017476 Walker B; other site 316275017477 D-loop; other site 316275017478 H-loop/switch region; other site 316275017479 HMMPfam hit to PF00005, ABC transporter, score 3.8e-63 316275017480 PS00211 ABC transporters family signature. 316275017481 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017482 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 4.8e-52 316275017484 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 316275017485 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 316275017486 Competence protein; Region: Competence; pfam03772 316275017487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 316275017488 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 2.4e-12 316275017490 HMMPfam hit to PF03772, Competence protein, score 1.2e-49 316275017491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 316275017493 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 316275017494 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 316275017495 DHHA2 domain; Region: DHHA2; pfam02833 316275017496 HMMPfam hit to PF02833, DHHA2 domain, score 3.8e-39 316275017497 HMMPfam hit to PF01368, DHH family, score 1.5e-05 316275017498 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276 316275017499 HMMPfam hit to PF05840, Bacteriophage replication gene A protein (G, score 4.4e-07 316275017500 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 316275017501 HMMPfam hit to PF04606, Ogr/Delta-like zinc finger,score 4.2e-14 316275017502 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 316275017503 active site 316275017504 HMMPfam hit to PF01844, HNH endonuclease, score 7.4e-08 316275017505 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 316275017506 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017507 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 316275017508 HMMPfam hit to PF04606, Ogr/Delta-like zinc finger,score 0.0029 316275017509 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 316275017510 HMMPfam hit to PF05125, Phage major capsid protein,P2 family, score 3.8e-71 316275017511 Homeodomain-like domain; Region: HTH_23; cl17451 316275017512 Winged helix-turn helix; Region: HTH_29; pfam13551 316275017513 Homeodomain-like domain; Region: HTH_32; pfam13565 316275017514 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275017515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275017516 HMMPfam hit to PF03235, Protein of unknown function DUF262, score 2.2e-55 316275017517 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275017518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275017519 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275017520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275017521 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275017522 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275017523 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275017524 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 316275017525 HMMPfam hit to PF07603, Protein of unknown function (DUF1566), score 1.3e-27 316275017526 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 316275017527 ligand binding site [chemical binding]; other site 316275017528 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275017529 HMMPfam hit to PF05433, Rickettsia 17 kDa surface antigen, score 5.8e-07 316275017530 HMMPfam hit to PF00691, OmpA family, score 4.4e-33 316275017532 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 316275017534 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 316275017535 HAMP domain; Region: HAMP; pfam00672 316275017536 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275017537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275017538 dimer interface [polypeptide binding]; other site 316275017539 putative CheW interface [polypeptide binding]; other site 316275017540 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.2e-55 316275017541 HMMPfam hit to PF00672, HAMP domain, score 2.5e-11 316275017543 HMMPfam hit to PF08269, Cache domain, score 1.8e-08 316275017545 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 316275017546 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 316275017547 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 316275017548 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 316275017549 DsbD alpha interface [polypeptide binding]; other site 316275017550 catalytic residues [active] 316275017552 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 6.7e-05 316275017553 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 316275017554 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 316275017555 catalytic residues [active] 316275017557 HMMPfam hit to PF08534, Redoxin, score 3.2e-08 316275017558 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 316275017559 PS00194 Thioredoxin family active site. 316275017560 Similar to Bacillus subtilis Signaling protein YkoW UniProt:O34311 (EMBL:Z99110 (800 aa) fasta scores: E()=2.5e-53, 37.611% id in 452 aa. CDS may be truncated by the insertion of the upstream IS element and subsequent recombination events 316275017561 HMMPfam hit to PF00563, EAL domain, score 1.9e-105 316275017562 HMMPfam hit to PF00990, GGDEF domain, score 1.5e-21 316275017563 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275017564 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275017565 HMMPfam hit to PF01609, Transposase DDE domain,score 5.8e-28 316275017566 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275017567 non-specific DNA binding site [nucleotide binding]; other site 316275017568 salt bridge; other site 316275017569 sequence-specific DNA binding site [nucleotide binding]; other site 316275017570 Cupin domain; Region: Cupin_2; cl17218 316275017571 HMMPfam hit to PF07883, Cupin domain, score 9.3e-08 316275017572 HMMPfam hit to PF01381, Helix-turn-helix, score 3.9e-15 316275017573 Predicted helix-turn-helix motif with score 1935.000, SD 5.78 at aa 49-70, sequence LTLEEASKRTGLARSTLSKIEN 316275017574 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 316275017575 lipoyl attachment site [posttranslational modification]; other site 316275017576 HMMPfam hit to PF01597, Glycine cleavage H-protein,score 1.4e-62 316275017577 glycine dehydrogenase; Provisional; Region: PRK05367 316275017578 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 316275017579 tetramer interface [polypeptide binding]; other site 316275017580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275017581 catalytic residue [active] 316275017582 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 316275017583 tetramer interface [polypeptide binding]; other site 316275017584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275017585 catalytic residue [active] 316275017586 HMMPfam hit to PF02347, Glycine cleavage system P-protein, score 5.8e-260 316275017587 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275017588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275017589 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=5.8e-119, 56.998% id in 493 aa. CDS contains a translational stop codon after codon 402 316275017590 Similar to Vibrio fischeri Methyl-accepting chemotaxis protein UniProt:Q5E0S4 (659 aa) fasta scores: E()=2e-135, 73.310% id in 577 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275017591 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 1.7e-09 316275017592 HMMPfam hit to PF00672, HAMP domain, score 1.6e-05 316275017594 HMMPfam hit to PF02065, Melibiase, score 0.0016 316275017595 PS00144 Asparaginase / glutaminase active site signature 1. 316275017596 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 316275017597 HAMP domain; Region: HAMP; pfam00672 316275017598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275017599 dimer interface [polypeptide binding]; other site 316275017600 putative CheW interface [polypeptide binding]; other site 316275017601 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 5.7e-45 316275017602 HMMPfam hit to PF00672, HAMP domain, score 8.2e-10 316275017604 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 316275017605 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 316275017606 molybdopterin cofactor binding site [chemical binding]; other site 316275017607 substrate binding site [chemical binding]; other site 316275017608 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 316275017609 molybdopterin cofactor binding site; other site 316275017610 HMMPfam hit to PF01568, Molydopterin dinucleotide binding dom, score 6.7e-30 316275017611 PS00932 Prokaryotic molybdopterin oxidoreductases signature 3. 316275017612 HMMPfam hit to PF00384, Molybdopterin oxidoreductase, score 4e-106 316275017613 PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 316275017614 Predicted helix-turn-helix motif with score 982.000, SD 2.53 at aa 325-346, sequence KTPEWASDICGLSPERIREFAK 316275017615 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 316275017616 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 316275017617 HMMPfam hit to PF03264, NapC/NirT cytochrome c family, N-termin, score 8.2e-95 316275017619 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 316275017620 HMMPfam hit to PF06796, Periplasmic nitrate reductase protein NapE, score 5.8e-26 316275017622 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 316275017623 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 316275017624 HMMPfam hit to PF06945, Protein of unknown function (DUF1289), score 1.7e-16 316275017625 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 316275017626 PS00287 Cysteine proteases inhibitors signature. 316275017627 Protein of unknown function (DUF2986); Region: DUF2986; pfam11661 316275017628 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275017629 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275017630 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275017631 dUMP phosphatase; Provisional; Region: PRK09449 316275017632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 316275017633 motif II; other site 316275017634 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 1.1e-21 316275017635 PS00761 Signal peptidases I signature 3. 316275017636 Predicted helix-turn-helix motif with score 1411.000, SD 3.99 at aa 68-89, sequence TRFEEWAKKVGVTPKAMNSAFM 316275017637 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 316275017638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275017639 Walker A/P-loop; other site 316275017640 ATP binding site [chemical binding]; other site 316275017641 Q-loop/lid; other site 316275017642 ABC transporter signature motif; other site 316275017643 Walker B; other site 316275017644 D-loop; other site 316275017645 H-loop/switch region; other site 316275017646 TOBE domain; Region: TOBE; cl01440 316275017647 HMMPfam hit to PF03459, TOBE domain, score 3.9e-12 316275017648 HMMPfam hit to PF00005, ABC transporter, score 1.3e-60 316275017649 PS00211 ABC transporters family signature. 316275017650 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017651 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 316275017652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275017653 dimer interface [polypeptide binding]; other site 316275017654 conserved gate region; other site 316275017655 putative PBP binding loops; other site 316275017656 ABC-ATPase subunit interface; other site 316275017657 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.5e-22 316275017659 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275017660 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 316275017661 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 316275017662 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 0.0097 316275017663 PS00044 Bacterial regulatory proteins, lysR family signature. 316275017665 cobyric acid synthase; Provisional; Region: PRK00784 316275017666 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 316275017667 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 316275017668 catalytic triad [active] 316275017669 HMMPfam hit to PF07685, CobB/CobQ-like glutamine amidotransferase do, score 7.4e-62 316275017670 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 6.4e-52 316275017671 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 316275017672 HMMPfam hit to PF04076, Domain unknown function (DUF388), score 3.1e-31 316275017673 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 316275017674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275017675 substrate binding pocket [chemical binding]; other site 316275017676 membrane-bound complex binding site; other site 316275017677 hinge residues; other site 316275017678 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 316275017679 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275017680 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275017681 catalytic residue [active] 316275017682 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.1e-24 316275017683 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 316275017684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275017685 substrate binding pocket [chemical binding]; other site 316275017686 membrane-bound complex binding site; other site 316275017687 hinge residues; other site 316275017688 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 316275017689 N-acetyl-D-glucosamine binding site [chemical binding]; other site 316275017690 catalytic residue [active] 316275017691 HMMPfam hit to PF01464, Transglycosylase SLT domain, score 1.2e-20 316275017692 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 316275017693 HMMPfam hit to PF05618, Protein of unknown function (DUF785), score 6.1e-57 316275017694 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275017695 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 316275017696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 316275017697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275017698 homodimer interface [polypeptide binding]; other site 316275017699 catalytic residue [active] 316275017700 HMMPfam hit to PF00155, Aminotransferase class I and II, score 8.9e-81 316275017701 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 316275017702 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 316275017703 PS01087 Radical activating enzymes signature. 316275017704 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 316275017705 ATP cone domain; Region: ATP-cone; pfam03477 316275017706 Class III ribonucleotide reductase; Region: RNR_III; cd01675 316275017707 effector binding site; other site 316275017708 active site 316275017709 Zn binding site [ion binding]; other site 316275017710 glycine loop; other site 316275017711 HMMPfam hit to PF01228, Glycine radical, score 5.3e-48 316275017712 PS00850 Glycine radical signature. 316275017713 HMMPfam hit to PF03477, ATP cone domain, score 4.1e-21 316275017714 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 316275017715 putative catalytic site [active] 316275017716 putative metal binding site [ion binding]; other site 316275017717 putative phosphate binding site [ion binding]; other site 316275017719 HMMPfam hit to PF03372,Endonuclease/Exonuclease/phosphatase fa, score 1.3e-06 316275017720 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 316275017721 HMMPfam hit to PF03352, Methyladenine glycosylase,score 2.9e-102 316275017723 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 316275017724 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 316275017725 Cu(I) binding site [ion binding]; other site 316275017727 HMMPfam hit to PF02630, SCO1/SenC, score 7.3e-28 316275017728 Protein of unknown function (DUF461); Region: DUF461; pfam04314 316275017729 HMMPfam hit to PF04314, Protein of unknown function (DUF461), score 2e-45 316275017730 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275017731 EamA-like transporter family; Region: EamA; pfam00892 316275017733 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 1.2e-16 316275017734 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.3e-15 316275017735 Weakly similar to part of Escherichia coli Core protein UniProt:O52673 (1410 aa) fasta scores: E()=9.8e-12, 20.829% id in 917 aa. CDS may be truncated by the insertion of the upstream IS element and subsequent recombination events 316275017736 HMMPfam hit to PF05593, RHS Repeat, score 3.8 316275017737 HMMPfam hit to PF05593, RHS Repeat, score 1.9 316275017738 HMMPfam hit to PF05593, RHS Repeat, score 7.3 316275017739 HMMPfam hit to PF05593, RHS Repeat, score 0.0012 316275017740 HMMPfam hit to PF05593, RHS Repeat, score 2.4 316275017741 HMMPfam hit to PF05593, RHS Repeat, score 1.5 316275017742 HMMPfam hit to PF05593, RHS Repeat, score 1.5 316275017743 HMMPfam hit to PF05593, RHS Repeat, score 1.1 316275017744 HMMPfam hit to PF05593, RHS Repeat, score 0.51 316275017745 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275017746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275017747 Homeodomain-like domain; Region: HTH_23; cl17451 316275017748 Winged helix-turn helix; Region: HTH_29; pfam13551 316275017749 Homeodomain-like domain; Region: HTH_32; pfam13565 316275017750 CDS is truncated by the insertion of the downstream IS element. There is an inframe translational stop codon 3 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275017751 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275017752 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316275017753 calcium mediated ligand binding site; other site 316275017754 intermolecular salt bridges; other site 316275017755 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316275017756 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316275017757 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 316275017758 Homeodomain-like domain; Region: HTH_23; cl17451 316275017759 Winged helix-turn helix; Region: HTH_29; pfam13551 316275017760 Homeodomain-like domain; Region: HTH_32; pfam13565 316275017761 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275017762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275017763 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 316275017764 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 316275017765 HMMPfam hit to PF01609, Transposase DDE domain,score 9.3e-30 316275017766 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 316275017767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275017768 Walker A/P-loop; other site 316275017769 ATP binding site [chemical binding]; other site 316275017770 Q-loop/lid; other site 316275017771 ABC transporter signature motif; other site 316275017772 Walker B; other site 316275017773 D-loop; other site 316275017774 H-loop/switch region; other site 316275017775 TOBE domain; Region: TOBE_2; pfam08402 316275017776 HMMPfam hit to PF08402, TOBE domain, score 5.6e-05 316275017777 HMMPfam hit to PF00005, ABC transporter, score 3.3e-62 316275017778 PS00211 ABC transporters family signature. 316275017779 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017780 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 316275017781 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 316275017782 HMMPfam hit to PF01547, Bacterial extracellular solute-binding prot, score 5.7e-05 316275017783 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 316275017784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275017785 catalytic residue [active] 316275017786 HMMPfam hit to PF00266, Aminotransferase class-V,score 7.6e-07 316275017787 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 316275017788 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316275017789 inhibitor-cofactor binding pocket; inhibition site 316275017790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275017791 catalytic residue [active] 316275017792 HMMPfam hit to PF00202, Aminotransferase class-III,score 1.6e-66 316275017793 Predicted helix-turn-helix motif with score 1009.000, SD 2.62 at aa 433-454, sequence ISREELTQALIIFEQAIAKVCK 316275017794 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 316275017795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 316275017796 motif II; other site 316275017797 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 316275017798 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 5.1e-15 316275017799 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 316275017800 HMMPfam hit to PF00462, Glutaredoxin, score 2.1e-07 316275017801 PS00195 Glutaredoxin active site. 316275017802 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 316275017803 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 316275017804 Na binding site [ion binding]; other site 316275017806 HMMPfam hit to PF00474, Sodium:solute symporter family, score 8.4e-126 316275017807 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 316275017808 NAD(P) binding site [chemical binding]; other site 316275017809 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 316275017810 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 316275017811 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 316275017812 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 316275017813 Glutamate binding site [chemical binding]; other site 316275017814 NAD binding site [chemical binding]; other site 316275017815 catalytic residues [active] 316275017816 HMMPfam hit to PF00171, Aldehyde dehydrogenase family, score 1.5e-100 316275017817 PS00070 Aldehyde dehydrogenases cysteine active site. 316275017818 HMMPfam hit to PF01619, Proline dehydrogenase,score 1.1e-110 316275017819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275017820 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275017821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275017822 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2e-09 316275017823 PS00041 Bacterial regulatory proteins, araC family signature. 316275017824 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3.4e-05 316275017825 Predicted helix-turn-helix motif with score 998.000, SD 2.59 at aa 170-191, sequence ITVSQLASTVFIGESQFYAIFK 316275017826 HMMPfam hit to PF07883, Cupin domain, score 0.0048 316275017827 PEGA domain; Region: PEGA; pfam08308 316275017828 Uncharacterized conserved protein [Function unknown]; Region: COG1262 316275017829 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 316275017830 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017831 PS00136 Serine proteases, subtilase family,aspartic acid active site. 316275017832 HMMPfam hit to PF08308, PEGA domain, score 5.6e-23 316275017833 HMMPfam hit to PF03781, Domain of unknown function (DUF323), score 1.1e-58 316275017834 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 316275017835 active site 316275017836 P-loop; other site 316275017837 phosphorylation site [posttranslational modification] 316275017838 HMMPfam hit to PF02302, PTS system,Lactose/Cellobiose specific IIB, score 2.4e-19 316275017839 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 316275017840 HMMPfam hit to PF04215, Putative sugar-specific permease, SgaT/UlaA, score 3e-110 316275017842 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275017843 active site 316275017844 phosphorylation site [posttranslational modification] 316275017845 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 1e-21 316275017846 PS00372 PTS EIIA domains phosphorylation site signature 2. 316275017847 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 316275017849 HMMPfam hit to PF03649, Uncharacterised protein family (UPF0014), score 4e-20 316275017850 PS00237 G-protein coupled receptors signature. 316275017851 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 316275017853 Similar to Photobacterium profundum Hypothetical multidrug resistance efflux pump UniProt:Q1Z3I8 (350 aa) fasta scores: E()=9.6e-57, 48.851% id in 348 aa. CDS is disrupted by the insertion of an IS element after codon 132 316275017854 HMMPfam hit to PF00529, HlyD family secretion protein, score 5.2e-11 316275017855 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275017856 Putative transposase; Region: Y2_Tnp; pfam04986 316275017858 Similar to Escherichia coli Protein tas UniProt:P0A9T4 (346 aa) fasta scores: E()=1.2e-46, 41.667% id in 348 aa. The insertion of the downstream IS element truncates the last 6 amino acid residues of the CDS. There is an inframe translational stop 10 codon amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275017859 HMMPfam hit to PF00248, Aldo/keto reductase family,score 1.1e-43 316275017860 Similar to Pseudoalteromonas haloplanktis Putative orphan protein; putative transposase UniProt:Q3IIG2 (99 aa) fasta scores: E()=0.041, 35.3% id in 51 aa. CDS contains a frameshift and a deletion of 32 amino acid residues after codon 55 316275017861 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275017862 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275017863 HMMPfam hit to PF05717, IS66 Orf2 like protein,score 1.4e-31 316275017864 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275017865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275017866 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275017867 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275017868 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275017869 AAA domain; Region: AAA_33; pfam13671 316275017870 AAA domain; Region: AAA_17; pfam13207 316275017871 PS00017 ATP/GTP-binding site motif A (P-loop). 316275017872 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275017873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275017874 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275017875 putative effector binding pocket; other site 316275017876 dimerization interface [polypeptide binding]; other site 316275017877 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.6e-33 316275017878 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 2.1e-17 316275017879 Predicted helix-turn-helix motif with score 2074.000, SD 6.25 at aa 15-36, sequence GSFTAAAKKLGVTPSALSKLIT 316275017880 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 316275017881 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 316275017882 substrate-cofactor binding pocket; other site 316275017883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275017884 catalytic residue [active] 316275017885 HMMPfam hit to PF00202, Aminotransferase class-III,score 0.041 316275017886 HMMPfam hit to PF00155, Aminotransferase class I and II, score 5.9e-95 316275017887 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 316275017888 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 316275017889 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 316275017890 NAD(P) binding site [chemical binding]; other site 316275017891 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like domain, score 4.7e-41 316275017892 PS00059 Zinc-containing alcohol dehydrogenases signature. 316275017893 HMMPfam hit to PF00107, Zinc-binding dehydrogenase,score 2.8e-39 316275017894 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 316275017895 AAA domain; Region: AAA_32; pfam13654 316275017896 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 316275017897 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 316275017898 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 1.3e-05 316275017899 Similar to Vibrio fischeri Na(+)/H(+) antiporter UniProt:Q5DZK4 (513 aa) fasta scores: E()=4.3e-40, 81.481% id in 162 aa. CDS contains a frameshift and a deletion of 280 amino acid residues after codon 69. The sequence has been checked and is believed to be correct 316275017901 HMMPfam hit to PF03553, Na+/H+ antiporter family,score 3.5e-06 316275017902 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 316275017903 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 316275017904 PS00136 Serine proteases, subtilase family,aspartic acid active site. 316275017905 HMMPfam hit to PF01408, Oxidoreductase family,NAD-binding Rossm, score 5.9e-37 316275017906 HopJ type III effector protein; Region: HopJ; pfam08888 316275017907 Predicted acetyltransferase [General function prediction only]; Region: COG2388 316275017908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275017909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316275017910 putative substrate translocation pore; other site 316275017912 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.3e-14 316275017913 putative acetyltransferase YhhY; Provisional; Region: PRK10140 316275017914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275017915 Coenzyme A binding pocket [chemical binding]; other site 316275017916 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.2e-17 316275017917 hypothetical protein; Provisional; Region: PRK11019 316275017918 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 1.7e-18 316275017919 hypothetical protein; Validated; Region: PRK09071 316275017920 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 316275017921 HMMPfam hit to PF02885, Glycosyl transferase family, helical, score 5.1e-07 316275017922 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 316275017923 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 316275017924 DNA binding site [nucleotide binding] 316275017925 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 3.8e-07 316275017928 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 316275017930 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 316275017931 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 316275017932 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275017933 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275017934 HMMPfam hit to PF00529, HlyD family secretion protein, score 8.4e-20 316275017936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275017937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275017938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275017939 dimerization interface [polypeptide binding]; other site 316275017940 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.8e-12 316275017941 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.2e-21 316275017942 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 316275017943 AAA domain; Region: AAA_26; pfam13500 316275017944 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 2e-18 316275017945 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 316275017946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275017947 S-adenosylmethionine binding site [chemical binding]; other site 316275017948 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 2.6e-05 316275017949 HMMPfam hit to PF08241, Methyltransferase domain,score 4.5e-31 316275017950 HMMPfam hit to PF08242, Methyltransferase domain,score 6.3e-14 316275017951 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 316275017952 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 316275017953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275017954 catalytic residue [active] 316275017955 HMMPfam hit to PF00155, Aminotransferase class I and II, score 4.3e-58 316275017956 HMMPfam hit to PF00266, Aminotransferase class-V,score 0.00031 316275017957 HMMPfam hit to PF01212, Beta-eliminating lyase,score 0.0014 316275017958 HMMPfam hit to PF00202, Aminotransferase class-III,score 0.0045 316275017959 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 316275017960 biotin synthase; Provisional; Region: PRK15108 316275017961 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275017962 FeS/SAM binding site; other site 316275017963 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 316275017964 HMMPfam hit to PF06968, Biotin and Thiamin Synthesis associated d, score 9.5e-51 316275017965 HMMPfam hit to PF04055, Radical SAM superfamily,score 4.1e-23 316275017966 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 316275017967 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 316275017968 inhibitor-cofactor binding pocket; inhibition site 316275017969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275017970 catalytic residue [active] 316275017971 HMMPfam hit to PF00202, Aminotransferase class-III,score 6e-146 316275017972 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 316275017974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 316275017975 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 316275017976 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 2.1e-09 316275017977 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 316275017978 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 316275017979 putative aromatic amino acid binding site; other site 316275017980 PAS domain; Region: PAS; smart00091 316275017981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 316275017982 Walker A motif; other site 316275017983 ATP binding site [chemical binding]; other site 316275017984 Walker B motif; other site 316275017985 arginine finger; other site 316275017986 Predicted helix-turn-helix motif with score 1566.000, SD 4.52 at aa 487-508, sequence PSSRKLAKRLGVSHTAIANKLR 316275017987 HMMPfam hit to PF00158, Sigma-54 interaction domain, score 5.4e-109 316275017988 PS00676 Sigma-54 interaction domain ATP-binding region B signature. 316275017989 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 316275017990 HMMPfam hit to PF00989, PAS fold, score 0.00034 316275017991 HMMPfam hit to PF01842, ACT domain, score 0.00023 316275017992 Protein of unknown function (DUF523); Region: DUF523; pfam04463 316275017993 Uncharacterized conserved protein [Function unknown]; Region: COG3272 316275017994 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 316275017995 HMMPfam hit to PF04463, Protein of unknown function (DUF523), score 6.4e-44 316275017996 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 316275017997 HMMPfam hit to PF08349, Protein of unknown function (DUF1722), score 3.9e-62 316275017998 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 316275017999 DNA photolyase; Region: DNA_photolyase; pfam00875 316275018000 HMMPfam hit to PF00875, DNA photolyase, score 1.4e-29 316275018001 HMMPfam hit to PF03441, FAD binding domain of DNA photolyase, score 8.2e-115 316275018002 PS00691 DNA photolyases class 1 signature 2. 316275018003 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 316275018004 metal binding site [ion binding]; metal-binding site 316275018005 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 316275018006 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 316275018007 Protein of unknown function, DUF399; Region: DUF399; pfam04187 316275018008 HMMPfam hit to PF04187, Protein of unknown function, DUF399, score 2.5e-85 316275018009 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275018010 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 316275018011 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018012 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 316275018014 Similar to Vibrio fischeri Cyclopropane-fatty-acyl-phospholipid synthase UniProt:Q5DZG6 (418 aa) fasta scores: E()=1e-137, 86.019% id in 422 aa. CDS contains a frameshift after codon 245. The sequence has been checked and is believed to be correct 316275018015 HMMPfam hit to PF02353,Cyclopropane-fatty-acyl-phospholipid synthas, score 2.3e-18 316275018016 HMMPfam hit to PF08242, Methyltransferase domain,score 2.3e-11 316275018017 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 316275018018 HMMPfam hit to PF07103, Protein of unknown function (DUF1365), score 1.3e-95 316275018019 Similar to Vibrio fischeri Putative dehydrogenase UniProt:Q5DZG4 (432 aa) fasta scores: E()=6.8e-108,80.831% id in 313 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018020 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275018021 Putative transposase; Region: Y2_Tnp; pfam04986 316275018022 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018024 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018025 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018026 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018027 Similar to N-terminal part of Vibrio vulnificus Hypothetical protein UniProt:Q7MCW1 (682 aa) fasta scores: E()=4.5e-39, 44.727% id in 275 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275018029 Cytochrome c553 [Energy production and conversion]; Region: COG2863 316275018030 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 316275018031 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 316275018032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 316275018033 catalytic residue [active] 316275018034 HMMPfam hit to PF00266, Aminotransferase class-V,score 3.7e-59 316275018035 Biofilm formation and stress response factor; Region: BsmA; cl01794 316275018036 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 316275018037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275018038 putative substrate translocation pore; other site 316275018040 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.3e-46 316275018041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275018042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275018043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275018044 dimerization interface [polypeptide binding]; other site 316275018045 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 7.9e-12 316275018046 Predicted helix-turn-helix motif with score 1297.000, SD 3.60 at aa 17-38, sequence GSFNAAAFQLNTSGSAISKRIN 316275018047 PS00044 Bacterial regulatory proteins, lysR family signature. 316275018048 HMMPfam hit to PF03466, LysR substrate binding domain, score 5.6e-25 316275018049 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316275018051 HMMPfam hit to PF01810, LysE type translocator,score 2.9e-09 316275018052 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 316275018053 GSH binding site [chemical binding]; other site 316275018054 catalytic residues [active] 316275018055 HMMPfam hit to PF00462, Glutaredoxin, score 5.7e-17 316275018056 PS00195 Glutaredoxin active site. 316275018057 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 316275018058 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275018059 substrate binding pocket [chemical binding]; other site 316275018060 membrane-bound complex binding site; other site 316275018061 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 316275018062 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 316275018063 substrate binding pocket [chemical binding]; other site 316275018064 membrane-bound complex binding site; other site 316275018065 hinge residues; other site 316275018066 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018068 metal binding site [ion binding]; metal-binding site 316275018069 active site 316275018070 I-site; other site 316275018072 HMMPfam hit to PF00990, GGDEF domain, score 1.9e-59 316275018073 putative hydrolase; Validated; Region: PRK09248 316275018074 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 316275018075 active site 316275018076 HMMPfam hit to PF02811, PHP domain, score 1.1e-21 316275018078 Predicted helix-turn-helix motif with score 1128.000, SD 3.03 at aa 19-40, sequence AFQSRLSKELNVTGVTLSRFLW 316275018079 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 316275018080 Haemolytic domain; Region: Haemolytic; pfam01809 316275018081 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 2.7e-09 316275018083 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275018084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275018085 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 2.4e-10 316275018086 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 1.9e-07 316275018087 Predicted helix-turn-helix motif with score 1740.000, SD 5.11 at aa 198-219, sequence IDRSSIANRFNISPNHLSRMFR 316275018088 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 316275018089 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275018090 active site 316275018091 phosphorylation site [posttranslational modification] 316275018092 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 316275018093 active site 316275018094 P-loop; other site 316275018095 phosphorylation site [posttranslational modification] 316275018096 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 316275018097 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phos, score 1.1e-17 316275018098 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 1.1e-46 316275018099 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 6.6e-10 316275018101 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275018102 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 316275018103 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 316275018104 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 316275018105 HMMPfam hit to PF01238, Phosphomannose isomerase type I, score 9e-90 316275018106 PS00965 Phosphomannose isomerase type I signature 1. 316275018107 PS00966 Phosphomannose isomerase type I signature 2. 316275018108 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 316275018109 regulatory protein interface [polypeptide binding]; other site 316275018110 regulatory phosphorylation site [posttranslational modification]; other site 316275018111 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275018112 active site 316275018113 phosphorylation site [posttranslational modification] 316275018114 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 316275018115 active site 316275018116 P-loop; other site 316275018117 phosphorylation site [posttranslational modification] 316275018118 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 2.6e-38 316275018119 Similar to Escherichia coli Fructose-like permease IIC component 2 FrwC UniProt:P32672 (359 aa) fasta scores: E()=2e-46, 45.930% id in 344 aa. CDS contains a frameshift after codon 85. The sequence has been checked and is believed to be correct 316275018120 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 2.7e-12 316275018121 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 0.00013 316275018123 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 5.3e-44 316275018124 Similar to Vibrio fischeri Short chain dehydrogenase UniProt:Q5DZF1 (390 aa) fasta scores: E()=1.9e-112, 75.897% id in 390 aa. CDS is disrupted by the insertion of an IS element after codon 380 316275018125 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275018126 Putative transposase; Region: Y2_Tnp; pfam04986 316275018127 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 316275018128 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 316275018129 HMMPfam hit to PF03544, Gram-negative bacterial tonB protein, score 4.1e-08 316275018131 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 316275018132 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 316275018133 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 3e-51 316275018135 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 316275018136 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 9.4e-28 316275018138 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 316275018139 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 1.2e-44 316275018141 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 316275018142 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 316275018143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275018144 ABC-ATPase subunit interface; other site 316275018145 dimer interface [polypeptide binding]; other site 316275018146 putative PBP binding regions; other site 316275018147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275018148 ABC-ATPase subunit interface; other site 316275018149 dimer interface [polypeptide binding]; other site 316275018150 putative PBP binding regions; other site 316275018151 HMMPfam hit to PF01032, FecCD transport family,score 3.5e-50 316275018152 HMMPfam hit to PF00950, ABC 3 transport family,score 0.00027 316275018154 HMMPfam hit to PF01032, FecCD transport family,score 1.1e-24 316275018155 Similar to Vibrio hollisae Periplasmic binding protein HatD UniProt:Q4H464 (299 aa) fasta scores: E()=1.3e-25, 32.107% id in 299 aa. CDS contains a frameshift after codon 145. The sequence has been checked and is believed to be correct 316275018156 HMMPfam hit to PF01497, Periplasmic binding protein, score 2.1e-22 316275018157 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316275018158 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316275018159 Walker A/P-loop; other site 316275018160 ATP binding site [chemical binding]; other site 316275018161 Q-loop/lid; other site 316275018162 ABC transporter signature motif; other site 316275018163 Walker B; other site 316275018164 D-loop; other site 316275018165 H-loop/switch region; other site 316275018166 HMMPfam hit to PF00005, ABC transporter, score 1e-45 316275018167 PS00211 ABC transporters family signature. 316275018168 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018169 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 316275018170 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 316275018171 N-terminal plug; other site 316275018172 ligand-binding site [chemical binding]; other site 316275018173 HMMPfam hit to PF00593, TonB dependent receptor,score 1.2e-19 316275018174 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018175 HMMPfam hit to PF07715, TonB-dependent Receptor Plug Domain, score 9.1e-18 316275018177 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275018178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275018179 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 316275018180 HMMPfam hit to PF06445, Bacterial transcription activator, effect, score 3.5e-16 316275018181 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 1.8e-07 316275018182 PS00041 Bacterial regulatory proteins, araC family signature. 316275018183 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix pro, score 1.3e-07 316275018184 Predicted helix-turn-helix motif with score 1134.000, SD 3.05 at aa 29-50, sequence LSVEILAEMSCWSRWQLQRVFL 316275018185 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 316275018186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275018187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275018188 ABC transporter; Region: ABC_tran_2; pfam12848 316275018189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 316275018190 HMMPfam hit to PF00005, ABC transporter, score 8.6e-41 316275018191 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018192 HMMPfam hit to PF00005, ABC transporter, score 5.3e-38 316275018193 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018194 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 316275018195 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 316275018196 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 316275018197 FMN binding site [chemical binding]; other site 316275018198 active site 316275018199 substrate binding site [chemical binding]; other site 316275018200 catalytic residue [active] 316275018201 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 6.6e-88 316275018202 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 316275018203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275018204 putative substrate translocation pore; other site 316275018206 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 6.8e-46 316275018207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275018208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275018209 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 316275018210 putative effector binding pocket; other site 316275018211 dimerization interface [polypeptide binding]; other site 316275018212 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 4.1e-15 316275018213 HMMPfam hit to PF03466, LysR substrate binding domain, score 6.9e-40 316275018215 PS00037 Myb DNA-binding domain repeat signature 1. 316275018216 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275018217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275018218 Homeodomain-like domain; Region: HTH_23; cl17451 316275018219 Winged helix-turn helix; Region: HTH_29; pfam13551 316275018220 Homeodomain-like domain; Region: HTH_32; pfam13565 316275018221 Similar to Enterobacter aerogenes Maltose transport system permease protein MalF UniProt:P18812 (514 aa) fasta scores: E()=1.5e-57, 78.534% id in 191 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018223 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275018224 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 316275018225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275018226 dimer interface [polypeptide binding]; other site 316275018227 conserved gate region; other site 316275018228 putative PBP binding loops; other site 316275018229 ABC-ATPase subunit interface; other site 316275018231 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.4e-17 316275018232 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 316275018233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018235 metal binding site [ion binding]; metal-binding site 316275018236 active site 316275018237 I-site; other site 316275018238 HMMPfam hit to PF00990, GGDEF domain, score 2.2e-53 316275018239 Response regulator receiver domain; Region: Response_reg; pfam00072 316275018240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275018241 active site 316275018242 phosphorylation site [posttranslational modification] 316275018243 intermolecular recognition site; other site 316275018244 dimerization interface [polypeptide binding]; other site 316275018245 HMMPfam hit to PF00072, Response regulator receiver domain, score 9.4e-30 316275018246 propionate/acetate kinase; Provisional; Region: PRK12379 316275018247 acetate kinase; Reviewed; Region: PRK12440 316275018248 HMMPfam hit to PF00871, Acetokinase family, score 1.1e-175 316275018249 PS01075 Acetate and butyrate kinases family signature 1. 316275018250 PS01076 Acetate and butyrate kinases family signature 2. 316275018251 Similar to Vibrio cholerae Hypothetical protein VCA0020 UniProt:Q9KNE5 (1085 aa) fasta scores: E()=1.4e-188, 46.452% id in 1085 aa. CDS contains a nonsense mutation (TAA) after codon 568, and a frameshift after codon 943. CDS is truncated by the insertion of the downstream IS element. There is an inframe translational stop codon amino acid residues further downstream within the IS element. The sequence has been checked and is believed to be correct 316275018253 Homeodomain-like domain; Region: HTH_23; cl17451 316275018254 Winged helix-turn helix; Region: HTH_29; pfam13551 316275018255 Homeodomain-like domain; Region: HTH_32; pfam13565 316275018256 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275018257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275018258 Similar to Escherichia coli Maltose transport system permease protein MalF UniProt:P02916 (514 aa) fasta scores: E()=4.7e-47, 43.322% id in 307 aa. CDS is truncated by the insertion of the downstream and upstream IS elements and subsequent recombination events 316275018260 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018261 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018262 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018263 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018264 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018265 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275018266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018267 Similar to N-terminal part of Vibrio fischeri Cellulose synthase regulatory subunit UniProt:Q5DZ43 (764 aa) fasta scores: E()=2.4e-37, 69.182% id in 159 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275018269 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 316275018270 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 316275018271 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 316275018272 DXD motif; other site 316275018273 PilZ domain; Region: PilZ; pfam07238 316275018274 HMMPfam hit to PF07238, PilZ domain, score 1.6e-16 316275018276 HMMPfam hit to PF00535, Glycosyl transferase family, score 4.3e-25 316275018277 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 316275018278 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 316275018280 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 316275018282 Domain of unknown function (DUF386); Region: DUF386; cl01047 316275018283 HMMPfam hit to PF04074, Domain of unknown function (DUF386), score 1.8e-36 316275018284 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 316275018285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 316275018286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 316275018287 Predicted helix-turn-helix motif with score 1285.000, SD 3.56 at aa 252-273, sequence PTLEFVADKVGMKPLTLQRRLQ 316275018288 HMMPfam hit to PF00165, Bacterial regulatory helix-turn-helix protei, score 3e-07 316275018290 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 316275018291 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 316275018292 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275018294 HMMPfam hit to PF00529, HlyD family secretion protein, score 0.00038 316275018295 Similar to Vibrio harveyi Autoinducer 1 sensor kinase/phosphatase LuxN UniProt:P54301 (849 aa) fasta scores: E()=0, 78.276% id in 847 aa. CDS contains a frameshift after codon 431. The sequence has been checked and is believed to be correct 316275018297 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 2.2e-07 316275018298 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.4e-20 316275018299 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-19 316275018300 recombination regulator RecX; Reviewed; Region: recX; PRK00117 316275018301 RecX family; Region: RecX; cl00936 316275018302 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018303 Similar to Photobacterium profundum 3tck Hypothetical transcriptional regulator UniProt:Q1YZV2 (478 aa) fasta scores: E()=5e-102, 59.619% id in 473 aa. CDS contains a frameshift after codon 411. The sequence has been checked and is believed to be correct 316275018304 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.5e-06 316275018305 HMMPfam hit to PF00392, Bacterial regulatory proteins, gntR family, score 1.1e-16 316275018306 Predicted helix-turn-helix motif with score 998.000, SD 2.59 at aa 37-58, sequence PSIRELSETLSVGKNTVIRAYE 316275018307 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 316275018308 EamA-like transporter family; Region: EamA; pfam00892 316275018310 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.9e-09 316275018311 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 2.3e-08 316275018312 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 316275018313 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 316275018314 Walker A/P-loop; other site 316275018315 ATP binding site [chemical binding]; other site 316275018316 Q-loop/lid; other site 316275018317 ABC transporter signature motif; other site 316275018318 Walker B; other site 316275018319 D-loop; other site 316275018320 H-loop/switch region; other site 316275018321 HMMPfam hit to PF00005, ABC transporter, score 1.9e-35 316275018322 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018324 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 316275018325 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 316275018326 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275018327 HMMPfam hit to PF00563, EAL domain, score 6.9e-65 316275018329 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018330 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018331 metal binding site [ion binding]; metal-binding site 316275018332 active site 316275018333 I-site; other site 316275018334 HMMPfam hit to PF00990, GGDEF domain, score 2.1e-38 316275018336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018337 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018338 metal binding site [ion binding]; metal-binding site 316275018339 active site 316275018340 I-site; other site 316275018341 HMMPfam hit to PF00990, GGDEF domain, score 1.1e-31 316275018343 Domain of unknown function DUF21; Region: DUF21; pfam01595 316275018344 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 316275018345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 316275018346 Transporter associated domain; Region: CorC_HlyC; smart01091 316275018347 HMMPfam hit to PF00571, CBS domain pair, score 3.3e-15 316275018348 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 2.2e-73 316275018350 maltose O-acetyltransferase; Provisional; Region: PRK10092 316275018351 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 316275018352 active site 316275018353 substrate binding site [chemical binding]; other site 316275018354 trimer interface [polypeptide binding]; other site 316275018355 CoA binding site [chemical binding]; other site 316275018356 PS00101 Hexapeptide-repeat containing-transferases signature. 316275018357 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.72 316275018358 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 18 316275018359 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 316275018360 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 56 316275018361 Similar to Vibrio fischeri Na(+) driven multidrug efflux pump UniProt:Q5DZ10 (456 aa) fasta scores: E()=6e-140, 88.596% id in 456 aa. CDS contains a frameshift after codon 229. The sequence has been checked and is believed to be correct 316275018363 HMMPfam hit to PF01554, MatE, score 1.8e-15 316275018364 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 316275018365 catalytic motif [active] 316275018366 Zn binding site [ion binding]; other site 316275018367 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1e-35 316275018368 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 316275018369 Autoinducer synthetase; Region: Autoind_synth; cl17404 316275018370 HMMPfam hit to PF00765, Autoinducer synthetase,score 5.3e-23 316275018371 PS00949 Autoinducers synthetases family signature. 316275018372 Autoinducer binding domain; Region: Autoind_bind; pfam03472 316275018373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316275018374 DNA binding residues [nucleotide binding] 316275018375 dimerization interface [polypeptide binding]; other site 316275018376 HMMPfam hit to PF03472, Autoinducer binding domain,score 1.3e-33 316275018377 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 2.9e-18 316275018378 Predicted helix-turn-helix motif with score 1670.000, SD 4.87 at aa 198-219, sequence KSRWEISKILGCSERTVTFHLA 316275018379 FMN reductase; Validated; Region: fre; PRK08051 316275018380 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 316275018381 FAD binding pocket [chemical binding]; other site 316275018382 FAD binding motif [chemical binding]; other site 316275018383 phosphate binding motif [ion binding]; other site 316275018384 beta-alpha-beta structure motif; other site 316275018385 NAD binding pocket [chemical binding]; other site 316275018386 HMMPfam hit to PF08030, Ferric reductase NAD binding domain, score 0.0017 316275018387 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 5.3e-32 316275018388 HMMPfam hit to PF00970, Oxidoreductase FAD-binding domain, score 0.0013 316275018389 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 316275018390 HMMPfam hit to PF04443, Acyl-protein synthetase,LuxE, score 3.6e-247 316275018391 Alkanal monooxygenase are flavin monoxygenases. Molecular oxygen is activated by reaction with reduced flavin mononucleotide (FMNH2) and reacts with an aldehyde to yield the carboxylic acid, oxidized flavin (FMN) and a blue-green light. Bacterial...; Region: Alkanal_monooxygenase; cd01096 316275018392 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 316275018393 dimer interface [polypeptide binding]; other site 316275018394 non-prolyl cis peptide bond; other site 316275018395 active site 316275018396 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 6.8e-166 316275018397 PS00494 Bacterial luciferase subunits signature. 316275018398 Alkanal monooxygenase are flavin monoxygenases. Molecular oxygen is activated by reaction with reduced flavin mononucleotide (FMNH2) and reacts with an aldehyde to yield the carboxylic acid, oxidized flavin (FMN) and a blue-green light. Bacterial...; Region: Alkanal_monooxygenase; cd01096 316275018399 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 316275018400 dimer interface [polypeptide binding]; other site 316275018401 non-prolyl cis peptide bond; other site 316275018402 active site 316275018403 HMMPfam hit to PF00296, Luciferase-like monooxygenase, score 5.1e-199 316275018404 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 316275018405 PS00494 Bacterial luciferase subunits signature. 316275018406 acyl transferase; Provisional; Region: luxD; PRK13604 316275018407 Acyl transferase; Region: Acyl_transf_2; pfam02273 316275018408 HMMPfam hit to PF02273, Acyl transferase, score 1.9e-181 316275018409 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 316275018410 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 316275018411 putative catalytic cysteine [active] 316275018412 HMMPfam hit to PF05893, Acyl-CoA reductase (LuxC),score 0 316275018413 PS00037 Myb DNA-binding domain repeat signature 1. 316275018414 Autoinducer binding domain; Region: Autoind_bind; pfam03472 316275018415 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 316275018416 DNA binding residues [nucleotide binding] 316275018417 dimerization interface [polypeptide binding]; other site 316275018418 HMMPfam hit to PF03472, Autoinducer binding domain,score 2e-36 316275018419 HMMPfam hit to PF00196, Bacterial regulatory proteins, luxR fami, score 3.7e-20 316275018420 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018421 PS00622 Bacterial regulatory proteins, luxR family signature. 316275018422 Predicted helix-turn-helix motif with score 1106.000, SD 2.95 at aa 198-219, sequence KSSWEISIILGCTERTVAFHLT 316275018423 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 316275018424 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316275018425 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 2.8e-05 316275018428 eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins; Region: eIF3G; cl13749 316275018429 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275018430 Putative transposase; Region: Y2_Tnp; pfam04986 316275018431 Similar to Vibrio fischeri Cytotoxic necrotizing factor 1 (Fragment) UniProt:O30972 (345 aa) fasta scores: E()=1.3e-100, 75.291% id in 344 aa; Similar to Vibrio fischeri Cytotoxic necrotizing factor 1 UniProt:O30972 (345 aa) fasta scores: E()=1.3e-100, 75.291% id in 344 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018432 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5DYZ8 (245 aa) fasta scores: E()=1.2e-40, 91.270% id in 126 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275018434 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018436 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018437 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018438 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018439 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275018440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018441 Similar to Shewanella putrefaciens Transposase UniProt:A2V575 (211 aa) fasta scores: E()=3.9e-33, 63.2% id in 133 aa. CDS is truncated by the insertion of an upstream IS element and subsequent recombination events 316275018442 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 316275018443 ATP binding site [chemical binding]; other site 316275018444 HMMPfam hit to PF01163, RIO1 family, score 5.4e-49 316275018445 PS00109 Tyrosine protein kinases specific active-site signature. 316275018446 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 316275018447 active site pocket [active] 316275018448 oxyanion hole [active] 316275018449 catalytic triad [active] 316275018450 active site nucleophile [active] 316275018451 HMMPfam hit to PF03575, Peptidase family S51, score 1.9e-66 316275018452 PS00120 Lipases, serine active site. 316275018453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275018454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275018455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 316275018456 dimerization interface [polypeptide binding]; other site 316275018457 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.8e-18 316275018458 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 5.6e-13 316275018459 Predicted helix-turn-helix motif with score 1308.000, SD 3.64 at aa 16-37, sequence NTLGKASEELNVDQTTIGRRIK 316275018460 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 316275018461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 316275018462 NAD(P) binding site [chemical binding]; other site 316275018463 active site 316275018464 HMMPfam hit to PF00106, short chain dehydrogenase,score 4.7e-10 316275018465 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018466 PS00061 Short-chain dehydrogenases/reductases family signature. 316275018467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 316275018468 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 316275018469 HMMPfam hit to PF01593, Flavin containing amine oxidoreductase, score 7.9e-05 316275018470 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 316275018471 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 316275018472 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 316275018473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275018474 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 316275018475 dimerization interface [polypeptide binding]; other site 316275018476 substrate binding pocket [chemical binding]; other site 316275018477 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.4e-13 316275018478 Predicted helix-turn-helix motif with score 1489.000, SD 4.26 at aa 19-40, sequence LSFSLAAKELNVTPAAIGQQVK 316275018479 PS00044 Bacterial regulatory proteins, lysR family signature. 316275018480 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.6e-31 316275018481 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 316275018482 Predicted permeases [General function prediction only]; Region: COG0679 316275018484 HMMPfam hit to PF03547, Auxin Efflux Carrier, score 7.6e-15 316275018485 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 316275018486 HMMPfam hit to PF05593, RHS Repeat, score 2.6 316275018487 HMMPfam hit to PF05593, RHS Repeat, score 0.076 316275018488 HMMPfam hit to PF05593, RHS Repeat, score 0.26 316275018489 HMMPfam hit to PF05593, RHS Repeat, score 2.2 316275018490 HMMPfam hit to PF05593, RHS Repeat, score 0.96 316275018491 Similar to Vibrio angustum Hypothetical protein UniProt:Q1ZM92 (397 aa) fasta scores: E()=1.4e-28, 39.016% id in 305 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275018492 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275018493 Putative transposase; Region: Y2_Tnp; pfam04986 316275018494 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018496 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018497 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018498 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018499 Similar to Shewanella sp. (strain W3-18-1) transposase is66. UniProt:A1RLT8 (EMBL:CP000503) (500 aa) fasta scores: E()=1.2e-84, 55.587% id in 358 aa. CDS is truncated by the insertion of an downstream IS element and subsequent recombination events 316275018500 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275018501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018502 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 316275018503 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 316275018504 active site 316275018505 P-loop; other site 316275018506 phosphorylation site [posttranslational modification] 316275018507 HMMPfam hit to PF02379, PTS system, Fructose specific IIB subuni, score 3.7e-40 316275018509 HMMPfam hit to PF02378, Phosphotransferase system,EIIC, score 0.00022 316275018510 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 316275018511 active site 316275018512 phosphorylation site [posttranslational modification] 316275018513 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 2e-06 316275018514 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018516 metal binding site [ion binding]; metal-binding site 316275018517 active site 316275018518 I-site; other site 316275018519 HMMPfam hit to PF00990, GGDEF domain, score 5.2e-28 316275018521 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 316275018522 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 316275018523 putative active site [active] 316275018524 Zn binding site [ion binding]; other site 316275018525 HMMPfam hit to PF00850, Histone deacetylase domain,score 2.5e-50 316275018526 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 316275018527 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 1.5e-118 316275018529 Similar to Vibrio fischeri Hypothetical cytosolic protein UniProt:Q5E026 (703 aa) fasta scores: E()=0,83.664% id in 655 aa. CDS contains a nonsense mutation (TCA to TAA) after codon 506. The sequence has been checked and is believed to be correct 316275018530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275018531 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 316275018532 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 316275018533 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 3.7e-166 316275018535 PS00873 Sodium:alanine symporter family signature. 316275018536 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 316275018537 dimer interface [polypeptide binding]; other site 316275018538 putative tRNA-binding site [nucleotide binding]; other site 316275018539 HMMPfam hit to PF01588, Putative tRNA binding domain, score 8.9e-42 316275018540 Similar to Escherichia coli HTH-type transcriptional regulator GalR UniProt:P03024 (343 aa) fasta scores: E()=2.6e-54, 51.466% id in 307 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events. In addition the CDS contains a frameshift after codon 218. The sequence has been checked and is believed to be correct 316275018541 HMMPfam hit to PF00356, Bacterial regulatory proteins, lacI family, score 9.2e-13 316275018542 Predicted helix-turn-helix motif with score 2084.000, SD 6.28 at aa 2-23, sequence ATIKDVAKEAGVSVATVSRVVN 316275018543 PS00356 Bacterial regulatory proteins, lacI family signature. 316275018544 HMMPfam hit to PF00532, Periplasmic binding proteins and sugar b, score 1.5e-07 316275018545 Similar to Pseudoalteromonas haloplanktis Putative orphan protein; putative transposase UniProt:Q3IIG2 (99 aa) fasta scores: E()=0.034, 37.5% id in 40 aa. CDS contains a frameshift and a deletion of 32 amino acid residues after codon 55 316275018546 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275018547 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018548 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018550 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018551 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018552 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018553 Similar to Vibrio cholerae non-o1. vcfq UniProt:Q83VI4 (EMBL:AB064660 (1381 aa) fasta scores: E()=1.8e-52, 35.429% id in 827 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018554 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 316275018555 Zn binding site [ion binding]; other site 316275018556 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 316275018557 active site 316275018558 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 316275018559 POT family; Region: PTR2; cl17359 316275018560 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 3.4e-05 316275018562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 316275018563 dimer interface [polypeptide binding]; other site 316275018564 phosphorylation site [posttranslational modification] 316275018565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 316275018566 ATP binding site [chemical binding]; other site 316275018567 Mg2+ binding site [ion binding]; other site 316275018568 G-X-G motif; other site 316275018569 Response regulator receiver domain; Region: Response_reg; pfam00072 316275018570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 316275018571 active site 316275018572 phosphorylation site [posttranslational modification] 316275018573 intermolecular recognition site; other site 316275018574 dimerization interface [polypeptide binding]; other site 316275018575 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.6e-26 316275018576 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HS, score 1.5e-45 316275018577 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 1.2e-20 316275018578 Heme NO binding; Region: HNOB; pfam07700 316275018579 HMMPfam hit to PF07700, Heme NO binding, score 8e-51 316275018580 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 316275018581 HMMPfam hit to PF06041, Bacterial protein of unknown function (DUF92, score 8.8e-87 316275018582 No significant database matches. CDS is truncated by the insertion of the downstream IS element. There is an inframe translational stop codon 8 amino acid residues further downstream within the IS element. The extended CDS may therefore be expressed and functional 316275018583 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275018584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018585 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018586 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018587 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018588 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018589 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018590 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 316275018591 PGAP1-like protein; Region: PGAP1; pfam07819 316275018592 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 316275018593 HMMPfam hit to PF01594, Domain of unknown function DUF20, score 9.7e-09 316275018595 aromatic amino acid exporter; Provisional; Region: PRK11689 316275018597 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 0.00014 316275018598 Cache domain; Region: Cache_1; pfam02743 316275018599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 316275018600 dimerization interface [polypeptide binding]; other site 316275018601 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 316275018602 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 316275018603 dimer interface [polypeptide binding]; other site 316275018604 putative CheW interface [polypeptide binding]; other site 316275018605 HMMPfam hit to PF00672, HAMP domain, score 2.8e-18 316275018607 HMMPfam hit to PF00015, Methyl-accepting chemotaxis protein (MCP) s, score 4.2e-56 316275018608 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 316275018609 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 316275018610 NAD binding site [chemical binding]; other site 316275018611 sugar binding site [chemical binding]; other site 316275018612 divalent metal binding site [ion binding]; other site 316275018613 tetramer (dimer of dimers) interface [polypeptide binding]; other site 316275018614 dimer interface [polypeptide binding]; other site 316275018615 HMMPfam hit to PF02056, Family 4 glycosyl hydrolase, score 7.6e-139 316275018616 PS01324 Glycosyl hydrolases family 4 signature. 316275018617 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 316275018618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275018619 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 316275018620 dimerization interface [polypeptide binding]; other site 316275018621 substrate binding pocket [chemical binding]; other site 316275018622 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 8.2e-17 316275018623 Predicted helix-turn-helix motif with score 1339.000, SD 3.75 at aa 21-42, sequence LSFTLASEQLFLTQGAVSQRIK 316275018624 PS00044 Bacterial regulatory proteins, lysR family signature. 316275018625 HMMPfam hit to PF03466, LysR substrate binding domain, score 3.9e-29 316275018626 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 316275018627 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 316275018628 active site 316275018629 HIGH motif; other site 316275018630 dimer interface [polypeptide binding]; other site 316275018631 KMSKS motif; other site 316275018632 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 3.1e-72 316275018633 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 316275018634 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 316275018635 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 316275018636 Uncharacterized conserved protein [Function unknown]; Region: COG3379 316275018637 Sulfatase; Region: Sulfatase; cl17466 316275018638 HMMPfam hit to PF01663, Type I phosphodiesterase / nucleotide py, score 6e-05 316275018639 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316275018640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275018641 dimer interface [polypeptide binding]; other site 316275018642 conserved gate region; other site 316275018643 putative PBP binding loops; other site 316275018644 ABC-ATPase subunit interface; other site 316275018646 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 0.0015 316275018647 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 316275018648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 316275018649 dimer interface [polypeptide binding]; other site 316275018650 conserved gate region; other site 316275018651 putative PBP binding loops; other site 316275018652 ABC-ATPase subunit interface; other site 316275018653 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.6e-11 316275018655 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 316275018656 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275018657 Walker A/P-loop; other site 316275018658 ATP binding site [chemical binding]; other site 316275018659 Q-loop/lid; other site 316275018660 ABC transporter signature motif; other site 316275018661 Walker B; other site 316275018662 D-loop; other site 316275018663 H-loop/switch region; other site 316275018664 HMMPfam hit to PF00005, ABC transporter, score 2.6e-70 316275018665 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018666 PS00211 ABC transporters family signature. 316275018667 HMMPfam hit to PF08402, TOBE domain, score 0.0056 316275018668 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 316275018669 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 316275018670 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 0.0032 316275018671 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 316275018672 DNA-binding site [nucleotide binding]; DNA binding site 316275018673 RNA-binding motif; other site 316275018674 HMMPfam hit to PF00313, 'Cold-shock' DNA-binding domain, score 1.2e-40 316275018675 PS00352 'Cold-shock' DNA-binding domain signature. 316275018677 mechanosensitive channel MscS; Provisional; Region: PRK10334 316275018678 Mechanosensitive ion channel; Region: MS_channel; pfam00924 316275018679 HMMPfam hit to PF00924, Mechanosensitive ion channel, score 4.9e-65 316275018681 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 316275018682 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 316275018683 Predicted flavoprotein [General function prediction only]; Region: COG0431 316275018684 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 316275018685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 316275018686 active site 316275018687 metal binding site [ion binding]; metal-binding site 316275018688 HMMPfam hit to PF00903, Glyoxalase/Bleomycin resistance protein/Di, score 1.7e-13 316275018689 PS00934 Glyoxalase I signature 1. 316275018690 Similar to Vibrio fischeri Transcriptional regulators, LysR family. UniProt:Q5DYG6 (300 aa) fasta scores: E()=4.5e-93, 81.034% id in 290 aa. CDS contains a nonsense mutation (TAA) after codon 78. The sequence has been checked and is believed to be correct 316275018691 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 1.1e-16 316275018692 Predicted helix-turn-helix motif with score 1321.000, SD 3.69 at aa 30-51, sequence GSFTKAAHISGHSTSYISKEIG 316275018693 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-35 316275018694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 316275018695 TPR motif; other site 316275018696 TPR repeat; Region: TPR_11; pfam13414 316275018697 binding surface 316275018698 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.22 316275018699 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.041 316275018701 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 316275018702 HMMPfam hit to PF01810, LysE type translocator,score 6.5e-05 316275018704 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 316275018705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 316275018706 putative DNA binding site [nucleotide binding]; other site 316275018707 putative Zn2+ binding site [ion binding]; other site 316275018708 AsnC family; Region: AsnC_trans_reg; pfam01037 316275018709 Predicted helix-turn-helix motif with score 980.000, SD 2.52 at aa 18-39, sequence LTNVELSERIGLSPSATLRRVQ 316275018710 HMMPfam hit to PF01037, AsnC family, score 4.6e-19 316275018711 Cation efflux family; Region: Cation_efflux; cl00316 316275018712 HMMPfam hit to PF01545, Cation efflux family, score 1.6e-05 316275018714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275018715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275018716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 316275018717 dimerization interface [polypeptide binding]; other site 316275018718 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 6e-13 316275018719 Predicted helix-turn-helix motif with score 1704.000, SD 4.99 at aa 16-37, sequence GSIAEAARKLQKSRTTVSAALN 316275018720 HMMPfam hit to PF03466, LysR substrate binding domain, score 4.2e-07 316275018721 GGGtGRT protein; Region: GGGtGRT; pfam14057 316275018722 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 316275018723 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 316275018724 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018725 Similar to Vibrio fischeri Transcriptional regulators, LysR family UniProt:Q5DYC8 (320 aa) fasta scores: E()=4.7e-72, 74.170% id in 271 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018726 HMMPfam hit to PF03466, LysR substrate binding domain, score 2.9e-31 316275018727 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275018728 Putative transposase; Region: Y2_Tnp; pfam04986 316275018729 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) putative orphan protein putative transposase (is66 family element,orf2-like). UniProt:Q3IIG1 (EMBL:CR954246) (115 aa) fasta scores: E()=2.3e-15, 57.6% id in 59 aa. CDS contains a frameshift after codon 34 316275018730 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018732 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018733 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018734 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018735 Similar to Vibrio fischeri Transporter, divalent anion:sodium symporter family UniProt:Q5E185 (332 aa) fasta scores: E()=8.7e-66, 91.667% id in 216 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018737 PS01271 Sodium:sulfate symporter family signature. 316275018738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275018739 S-adenosylmethionine binding site [chemical binding]; other site 316275018740 HMMPfam hit to PF08241, Methyltransferase domain,score 6e-10 316275018741 HMMPfam hit to PF08242, Methyltransferase domain,score 8.7e-10 316275018742 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 316275018743 HNH endonuclease; Region: HNH_2; pfam13391 316275018744 CAAX protease self-immunity; Region: Abi; pfam02517 316275018746 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 3.3e-15 316275018747 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 316275018748 active site residue [active] 316275018749 HMMPfam hit to PF00581, Rhodanese-like domain,score 1.2e-12 316275018750 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 316275018751 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 316275018752 active site 316275018753 FMN binding site [chemical binding]; other site 316275018754 substrate binding site [chemical binding]; other site 316275018755 putative catalytic residue [active] 316275018756 HMMPfam hit to PF00724, NADH:flavin oxidoreductase / NADH oxidas, score 1.9e-74 316275018757 Similar to Vibrio parahaemolyticus Hypothetical protein UniProt:Q87JZ0 (161 aa) fasta scores: E()=1.2e-14,85.714% id in 42 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018758 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275018759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275018760 Homeodomain-like domain; Region: HTH_23; cl17451 316275018761 Winged helix-turn helix; Region: HTH_29; pfam13551 316275018762 Homeodomain-like domain; Region: HTH_32; pfam13565 316275018763 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018765 metal binding site [ion binding]; metal-binding site 316275018766 active site 316275018767 I-site; other site 316275018769 HMMPfam hit to PF00990, GGDEF domain, score 3.2e-21 316275018770 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 316275018772 Similar to Vibrio parahaemolyticus Hypothetical protein UniProt:Q87FP2 (182 aa) fasta scores: E()=2.4e-20,44.898% id in 147 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018773 Predicted helix-turn-helix motif with score 1096.000, SD 2.92 at aa 19-40, sequence LNTAYLAKLFGVPLSKINSIES 316275018774 DDE superfamily endonuclease; Region: DDE_3; pfam13358 316275018775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 316275018776 Homeodomain-like domain; Region: HTH_23; cl17451 316275018777 Winged helix-turn helix; Region: HTH_29; pfam13551 316275018778 Homeodomain-like domain; Region: HTH_32; pfam13565 316275018779 ornithine decarboxylase SpeF; Region: ODC_inducible; TIGR04301 316275018780 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 316275018781 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 316275018782 homodimer interface [polypeptide binding]; other site 316275018783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 316275018784 catalytic residue [active] 316275018785 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 316275018786 HMMPfam hit to PF03709, Orn/Lys/Arg decarboxylase,N-terminal doma, score 2.2e-10 316275018787 HMMPfam hit to PF01276, Orn/Lys/Arg decarboxylase,major domain, score 1.5e-298 316275018788 PS00196 Type-1 copper (blue) proteins signature. 316275018789 PS00703 Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site. 316275018790 HMMPfam hit to PF03711, Orn/Lys/Arg decarboxylase,C-terminal doma, score 3.5e-78 316275018791 putrescine transporter; Provisional; Region: potE; PRK10655 316275018793 HMMPfam hit to PF00324, Amino acid permease, score 6e-06 316275018794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 316275018795 HMMPfam hit to PF07661, MORN repeat variant, score 6.4 316275018796 HMMPfam hit to PF07661, MORN repeat variant, score 0.01 316275018797 HMMPfam hit to PF07661, MORN repeat variant, score 0.18 316275018798 HMMPfam hit to PF07661, MORN repeat variant, score 0.0047 316275018799 HMMPfam hit to PF07661, MORN repeat variant, score 0.12 316275018800 HMMPfam hit to PF07661, MORN repeat variant, score 3 316275018801 Similar to Escherichia coli HTH-type transcriptional regulator CynR UniProt:P27111 (299 aa) fasta scores: E()=5.9e-21, 29.930% id in 284 aa. CDS contains a frameshift after codon 219 316275018802 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.5e-41 316275018803 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix protei, score 1.3e-19 316275018804 PS00044 Bacterial regulatory proteins, lysR family signature. 316275018805 Predicted helix-turn-helix motif with score 1622.000, SD 4.71 at aa 27-48, sequence QNITHAAKALHIAQPALSVAIK 316275018806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 316275018807 Major Facilitator Superfamily; Region: MFS_1; pfam07690 316275018808 putative substrate translocation pore; other site 316275018810 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 4.6e-35 316275018811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018813 metal binding site [ion binding]; metal-binding site 316275018814 active site 316275018815 I-site; other site 316275018816 HMMPfam hit to PF00990, GGDEF domain, score 3.4e-47 316275018818 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 316275018819 HMMPfam hit to PF01923, Cobalamin adenosyltransferase, score 8.3e-07 316275018821 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 316275018822 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316275018823 intersubunit interface [polypeptide binding]; other site 316275018824 HMMPfam hit to PF01497, Periplasmic binding protein, score 4.2e-06 316275018825 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 316275018826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275018827 ABC-ATPase subunit interface; other site 316275018828 dimer interface [polypeptide binding]; other site 316275018829 putative PBP binding regions; other site 316275018831 HMMPfam hit to PF01032, FecCD transport family,score 1.8e-102 316275018832 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316275018833 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 316275018834 Walker A/P-loop; other site 316275018835 ATP binding site [chemical binding]; other site 316275018836 Q-loop/lid; other site 316275018837 ABC transporter signature motif; other site 316275018838 Walker B; other site 316275018839 D-loop; other site 316275018840 H-loop/switch region; other site 316275018841 HMMPfam hit to PF00005, ABC transporter, score 1.2e-48 316275018842 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018843 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 316275018844 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 316275018845 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 316275018846 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 3.9e-156 316275018847 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 5.8e-63 316275018848 Similar to Salmonella typhimurium Zinc transport protein ZntB UniProt:Q9EYX5 (327 aa) fasta scores: E()=2.7e-29, 33.837% id in 331 aa. CDS contains a nonsense mutation (TGA) after codon 114. The sequence has been checked and is believed to be correct 316275018849 HMMPfam hit to PF01544, CorA-like Mg2+ transporter protein, score 9.6e-05 316275018851 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 316275018852 dimer interface [polypeptide binding]; other site 316275018853 FMN binding site [chemical binding]; other site 316275018854 NADPH bind site [chemical binding]; other site 316275018855 HMMPfam hit to PF00881, Nitroreductase family,score 6e-44 316275018856 Predicted membrane protein [Function unknown]; Region: COG2119 316275018857 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 316275018858 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 316275018860 HMMPfam hit to PF01169, Uncharacterized protein family UPF0016, score 6.9e-07 316275018861 Transcriptional regulator [Transcription]; Region: LysR; COG0583 316275018862 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 316275018863 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 316275018864 substrate binding pocket [chemical binding]; other site 316275018865 dimerization interface [polypeptide binding]; other site 316275018866 HMMPfam hit to PF00126, Bacterial regulatory helix-turn-helix, score 1.4e-14 316275018867 Predicted helix-turn-helix motif with score 1368.000, SD 3.85 at aa 24-45, sequence HSVTQSAEILYMSPSSVSKTLS 316275018868 PS00044 Bacterial regulatory proteins, lysR family signature. 316275018869 HMMPfam hit to PF03466, LysR substrate binding domain, score 1.6e-05 316275018870 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 316275018871 Helix-turn-helix domain; Region: HTH_38; pfam13936 316275018872 Integrase core domain; Region: rve; pfam00665 316275018873 Predicted helix-turn-helix motif with score 1000.000, SD 2.59 at aa 24-45, sequence ISAREIGQKLKRSNGSISKELR 316275018874 HMMPfam hit to PF00665, Integrase core domain,score 1.1e-31 316275018875 Methyltransferase domain; Region: Methyltransf_31; pfam13847 316275018876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 316275018877 S-adenosylmethionine binding site [chemical binding]; other site 316275018878 HMMPfam hit to PF02390, Putative methyltransferase,score 0.00075 316275018879 HMMPfam hit to PF08241, Methyltransferase domain,score 1.9e-16 316275018880 HMMPfam hit to PF08242, Methyltransferase domain,score 9.5e-13 316275018881 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 316275018882 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 316275018883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 316275018884 FeS/SAM binding site; other site 316275018885 HMMPfam hit to PF04055, Radical SAM superfamily,score 7.5e-06 316275018886 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0025 316275018887 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275018888 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.00029 316275018889 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 316275018890 PS01087 Radical activating enzymes signature. 316275018891 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5DYW5 (508 aa) fasta scores: E()=1.7e-46, 91.608% id in 143 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018892 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275018893 Putative transposase; Region: Y2_Tnp; pfam04986 316275018894 Similar to Vibrio parahaemolyticus Multidrug resistance protein D UniProt:Q87HE9 (377 aa) fasta scores: E()=3.6e-42, 49.000% id in 300 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018895 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-07 316275018898 Similar to Shewanella sp. pv-4 Cytochrome c, class I precursor UniProt:Q33Z98 (353 aa) fasta scores: E()=6.1e-45, 61.257% id in 191 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275018899 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 316275018900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018901 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 316275018902 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 316275018903 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 316275018904 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 316275018905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 316275018906 Similar to Pseudoalteromonas haloplanktis (strain TAC 125) putative orphan protein putative transposase. UniProt:Q3IIG2 (EMBL:CR954246) (99 aa) fasta scores: E()=0.041, 35.294% id in 51 aa. CDS contains a frameshift and a deletion of 32 amino acid residues after codon 55 316275018907 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 316275018908 HMMPfam hit to PF05618, Protein of unknown function (DUF785), score 1.6e-17 316275018909 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 316275018910 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 316275018911 Sel1-like repeats; Region: SEL1; smart00671 316275018912 Similar to Vibrio fischeri Acriflavin resistance plasma membrane protein UniProt:Q5E0L9 (1016 aa) fasta scores: E()=0, 88.158% id in 760 aa. CDS is truncated by the insertion of the upstream IS element and subsequent recombination events 316275018913 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275018914 Putative transposase; Region: Y2_Tnp; pfam04986 316275018915 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 316275018916 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 316275018917 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 316275018918 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 316275018919 Walker A/P-loop; other site 316275018920 ATP binding site [chemical binding]; other site 316275018921 Q-loop/lid; other site 316275018922 ABC transporter signature motif; other site 316275018923 Walker B; other site 316275018924 D-loop; other site 316275018925 H-loop/switch region; other site 316275018926 HMMPfam hit to PF00005, ABC transporter, score 1.1e-53 316275018927 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018928 PS00061 Short-chain dehydrogenases/reductases family signature. 316275018929 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 3.4e-07 316275018931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 316275018932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 316275018933 metal binding site [ion binding]; metal-binding site 316275018934 active site 316275018935 I-site; other site 316275018936 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 316275018937 HMMPfam hit to PF00563, EAL domain, score 2.8e-14 316275018938 HMMPfam hit to PF00990, GGDEF domain, score 3.1e-08 316275018939 HMMPfam hit to PF00672, HAMP domain, score 3e-05 316275018941 Similar to Vibrio fischeri Hypothetical protein UniProt:Q5DYA9 (221 aa) fasta scores: E()=5.5e-72, 78.733% id in 221 aa. CDS contains a nonsense mutation (GAA to TAA) after codon 113. The sequence has been checked and is believed to be correct 316275018942 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 316275018943 HlyD family secretion protein; Region: HlyD_3; pfam13437 316275018944 PS00543 HlyD family secretion proteins signature. 316275018945 HMMPfam hit to PF00529, HlyD family secretion protein, score 2.6e-07 316275018947 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 316275018948 Helicase; Region: Helicase_RecD; pfam05127 316275018949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 316275018950 Coenzyme A binding pocket [chemical binding]; other site 316275018951 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 316275018952 HMMPfam hit to PF05127, Putative ATPase (DUF699),score 3.2e-60 316275018953 PS00017 ATP/GTP-binding site motif A (P-loop). 316275018954 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 316275018955 metal binding site [ion binding]; metal-binding site 316275018956 plasmid-partitioning protein; Provisional; Region: PRK13698 316275018957 ParB-like nuclease domain; Region: ParBc; pfam02195 316275018958 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 316275018959 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275018960 P-loop; other site 316275018961 Magnesium ion binding site [ion binding]; other site 316275018962 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275018963 Magnesium ion binding site [ion binding]; other site 316275018964 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 6.2e-16 316275018965 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 316275018966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 316275018967 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 316275018968 catalytic residues [active] 316275018969 catalytic nucleophile [active] 316275018970 HMMPfam hit to PF00239, Resolvase, N terminal domain, score 6.2e-24 316275018971 PS00397 Site-specific recombinases active site. 316275018972 PS00398 Site-specific recombinases signature 2. 316275018973 Predicted helix-turn-helix motif with score 1241.000, SD 3.41 at aa 181-202, sequence LSVNATAKLVGVTARTVIRIVK 316275018974 hypothetical protein; Provisional; Region: PRK11027 316275018975 HMMPfam hit to PF04219, Protein of unknown function, DUF, score 2.8e-10 316275018976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 316275018977 DNA-binding site [nucleotide binding]; DNA binding site 316275018979 ParA-like protein; Provisional; Region: PHA02518 316275018980 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 316275018981 P-loop; other site 316275018982 Magnesium ion binding site [ion binding]; other site 316275018983 Predicted helix-turn-helix motif with score 1109.000, SD 2.96 at aa 6-27, sequence MIISFLSQKGGVTKSTLARSIA 316275018984 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 316275018985 DinI-like family; Region: DinI; cl11630 316275018986 HMMPfam hit to PF06183, DinI-like family, score 6.2e-16 316275018987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 316275018988 non-specific DNA binding site [nucleotide binding]; other site 316275018989 Predicted transcriptional regulator [Transcription]; Region: COG2932 316275018990 salt bridge; other site 316275018991 sequence-specific DNA binding site [nucleotide binding]; other site 316275018992 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 316275018993 Catalytic site [active] 316275018994 HMMPfam hit to PF00717, Peptidase S24-like, score 7.1e-10 316275018995 HMMPfam hit to PF01381, Helix-turn-helix, score 7.3e-16 316275018996 Predicted helix-turn-helix motif with score 2387.000, SD 7.32 at aa 17-38, sequence LSQESLAEKINVTKSTISQWEV 316275018997 TraY domain; Region: TraY; pfam05509 316275018998 Similar to N-terminal part of Vibrio fischeri Hypothetical protein UniProt:Q5DY82 (166 aa) fasta scores: E()=7.2e-16, 53.261% id in 92 aa. CDS is truncated by the insertion of the downstream IS element and subsequent recombination events 316275018999 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275019000 Putative transposase; Region: Y2_Tnp; pfam04986 316275019001 HMMPfam hit to PF04986, Putative transposase, score 2.2e-50 316275019002 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 316275019003 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 316275019004 HMMPfam hit to PF08401, Domain of unknown function (DUF1738), score 1.7e-71 316275019006 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 316275019007 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 316275019008 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 316275019009 HMMPfam hit to PF01526, Transposase, score 4.4e-17 316275019010 Similar to C-terminal part of Erwinia carotovora MobA protein UniProt:Q47385 (498 aa) fasta scores: E()=1.1e-13, 35.211% id in 284 aa. CDS is truncated by the insertion of the downstream and upstream IS elements and subsequent recombination events 316275019011 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275019012 Putative transposase; Region: Y2_Tnp; pfam04986 316275019013 HMMPfam hit to PF04986, Putative transposase, score 6.2e-49 316275019014 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 316275019015 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 316275019016 intersubunit interface [polypeptide binding]; other site 316275019017 HMMPfam hit to PF01497, Periplasmic binding protein, score 7e-05 316275019018 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 316275019019 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 316275019020 ABC-ATPase subunit interface; other site 316275019021 dimer interface [polypeptide binding]; other site 316275019022 putative PBP binding regions; other site 316275019024 HMMPfam hit to PF01032, FecCD transport family,score 4.3e-85 316275019025 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 316275019026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 316275019027 Walker A/P-loop; other site 316275019028 ATP binding site [chemical binding]; other site 316275019029 Q-loop/lid; other site 316275019030 ABC transporter signature motif; other site 316275019031 Walker B; other site 316275019032 D-loop; other site 316275019033 H-loop/switch region; other site 316275019034 HMMPfam hit to PF00005, ABC transporter, score 1.8e-42 316275019035 PS00017 ATP/GTP-binding site motif A (P-loop). 316275019036 PS00211 ABC transporters family signature. 316275019037 Helix-turn-helix domain; Region: HTH_28; pfam13518 316275019038 Winged helix-turn helix; Region: HTH_29; pfam13551 316275019039 Homeodomain-like domain; Region: HTH_32; pfam13565 316275019040 Integrase core domain; Region: rve; pfam00665 316275019041 Integrase core domain; Region: rve_3; cl15866 316275019042 HMMPfam hit to PF00665, Integrase core domain,score 1.2e-19 316275019043 Predicted helix-turn-helix motif with score 1434.000, SD 4.07 at aa 24-45, sequence LTQENASNTLNLTRRQVQRLVN 316275019044 Similar to Aliivibrio salmonicida Putative transposase UniProt:Q5EJX2 (359 aa) fasta scores: E()=1.2e-167, 99.7% id in 359 aa. CDS is disrupted by a 399 bp insertion 316275019045 Predicted helix-turn-helix motif with score 1355.000, SD 3.80 at aa 105-126, sequence HLCIEIGKEIGVSSSTISVIMK 316275019046 Replication-relaxation; Region: Replic_Relax; pfam13814 316275019047 Acyltransferase family; Region: Acyl_transf_3; pfam01757 316275019048 HMMPfam hit to PF01757, Acyltransferase family,score 2.9e-55 316275019050 Initiator Replication protein; Region: Rep_3; pfam01051 316275019051 HMMPfam hit to PF01051, Initiator Replication protein, score 3e-54 316275019052 Acyltransferase family; Region: Acyl_transf_3; pfam01757 316275019053 HMMPfam hit to PF01757, Acyltransferase family,score 1.6e-25 316275019055 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 316275019056 Putative transposase; Region: Y2_Tnp; pfam04986 316275019057 HMMPfam hit to PF04986, Putative transposase, score 6.2e-49