-- dump date 20140618_193602 -- class Genbank::CDS -- table cds_function -- id function YP_691721.1 ATPase involved in DNA replication initiation YP_691722.1 DNA polymerase sliding clamp subunit (PCNA homolog) YP_691723.1 Recombinational DNA repair ATPase (RecF pathway) YP_691724.1 DNA gyrase (topoisomerase II) B subunit YP_691725.1 play a role in the formation of nucleoide structure YP_691726.1 catalyzes the acylation of 1-acyl-sn-glycerol-3-phosphate to phosphatidic acid YP_691728.1 atp + glycine + trna(gly) = amp + diphosphate + glycyl-trna(gly) YP_691729.1 atp + glycine + trna(gly) = amp + diphosphate + glycyl-trna(gly) YP_691730.1 hydrolysis of the deoxyribose n-glycosidic bond to excise 3-methyladenine from the damaged dna polymer formed by alkylation lesions. YP_691731.1 unknown YP_691733.1 unknown YP_691734.1 regulation of transcription, DNA-dependent YP_691735.1 Predicted membrane protein YP_691736.1 unknown YP_691737.1 protein transporter YP_691739.1 transcriptional regulator YP_691740.1 2-methyl-3-oxopropanoate + coa + nad(+) = propanoyl-coa + co(2) + nadh YP_691741.1 Acyl-CoA + etf = 2,3-dehydroacyl-CoA + reduced etf. YP_691742.1 3-hydroxy-2-methylpropanoate + nad(+) = 2-methyl-3-oxopropanoate + nadh. YP_691743.1 it catalyses the first step of phytanic acid alpha-oxidation YP_691745.1 unknown YP_691746.1 involved in glutathione metabolism YP_691747.1 converts holo-acp to apo-acp by hydrolytic cleavage of the phosphopantetheine prosthetic group from acp. its physiological function is not clear (by similarity). holo-[acyl-carrier protein] + h(2)o = 4'-phosphopantetheine + apo-[acyl-carrier protein]. YP_691748.1 regulation of transcription YP_691750.1 activates the flagella regulon by activating transcription of flhdc. may activate qseb by phosphorylation YP_691751.1 DNA binding YP_691752.1 unknown YP_691753.1 involved in disulfide bond formation. functions probably as a disulfide isomerase with a narrower substrate specificity than dsbc YP_691754.1 Dihydroorotase and related cyclic amidohydrolases YP_691755.1 Aspartate carbamoyltransferase YP_691756.1 Pyrimidine operon attenuation YP_691757.1 electron transfer from hydrogen to oxygen YP_691758.1 unknown YP_691763.1 hydrolysis of water- soluble or insoluble esters, including triglycerides YP_691764.1 directly reducing organic hyperoxides in its reduced dithiol form YP_691768.1 unknown YP_691769.1 unknown YP_691770.1 Unknown YP_691771.1 removal of the ammonia group from a glutamate molecule and its subsequent transfer to a specific substrate, thus creating a new carbon-nitrogen group on the substrate YP_691772.1 Unknown YP_691774.1 regulation of transcription YP_691778.1 electron transport YP_691779.1 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome YP_691781.1 Ethanol + NAD = Acetaldehyde + NADH YP_691786.1 hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle YP_691787.1 works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone YP_691788.1 3-phosphoglycerate + NAD(+) = 3-phosphohydroxypyruvate + NADH. YP_691789.1 unknown YP_691793.1 unknown YP_691794.1 CBS YP_691795.1 transport system that facilitate potassium-efflux, possibly by potassium-proton antiport YP_691796.1 receptor for the siderophore, ferripyoverdine YP_691798.1 unknown YP_691799.1 acetyl-coa + ribosomal-protein l-serine = coa + ribosomal-protein n-acetyl-l-serine YP_691800.1 ggt plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. YP_691801.1 reversibly transfers an adenylyl group from atp to 4'- phosphopantetheine, yielding dephospho-coa (dpcoa) and pyrophosphate (atp + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-coa) YP_691802.1 Transposase and inactivated derivatives YP_691808.1 regulation of transcription, DNA-dependent YP_691809.1 Predicted hydrolase of the alpha YP_691812.1 may function as a membrane-associated protein kinase that phosphorylates glpr in response to environmental signals YP_691815.1 catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to s-lactoylglutathione ((r)-s-lactoylglutathione = glutathione + methylglyoxal) YP_691819.1 electron transport YP_691820.1 Involved in biosynthesis of the lippopolysaccharide (LPS) component lipid A by acylation of the intermediate (KDO)2-lipid IVa to form (KDO)2-(lauroyl)-lipid IVa YP_691823.1 Chemotaxis response regulator containing a CheY YP_691825.1 Methylase of chemotaxis methyl YP_691826.1 COG: Methyl-accepting chemotaxis protein YP_691827.1 Chemotaxis signal transduction protein regulates twitching motility YP_691828.1 FOG response regulatory protein for twitching motility YP_691829.1 response regulator involved in signal trasduction for pilus-biosynthesis YP_691830.1 ATP + gamma-l-glutamyl-l-cysteine + glycine = ADP + phosphate + glutathione. YP_691834.1 unknown YP_691836.1 carboxylic ester hydrolase. YP_691837.1 alcohol + nad(+) = an aldehyde or ketone + nadh YP_691839.1 hydrolase YP_691840.1 a monocarboxylic acid amide + h(2)o = a monocarboxylate + nh(3) YP_691841.1 regulation of transcription, DNA-dependent YP_691842.1 initial step of alkane degradation YP_691844.1 P pilus assembly protein YP_691845.1 P pilus assembly protein YP_691846.1 required for pilus biogenesis. YP_691849.1 tRNA and rRNA cytosine YP_691850.1 Acylation of methionyl-tRNA YP_691851.1 required for the removal of the formyl group at the N-terminus of nascent polypeptide chains: converts N-formyl-L-methionine to formate + L-methionine YP_691852.1 may have a general peptidoglycan binding function YP_691853.1 DNA processing YP_691854.1 translation factor, this domain has been shown to preferentially bind to dsRNA YP_691855.1 coproporphyrinogen-iii + o(2) = protoporphyrinogen-ix + 2 co(2). YP_691856.1 shikimate + NADP(+) = 5-dehydroshikimate + NADPH. YP_691860.1 may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. can cleave N-acetyl-L-ala4. hydrolysis of oligopeptides, with broad specificity. gly or ala commonly occur as p1 or p1' residues, but more distant residues are also important, as is shown by the fact that z-gly-pro-gly-|-gly-pro-ala is cleaved, but not z-(gly)5. YP_691863.1 unknown YP_691864.1 transcriptional regulator YP_691865.1 Flavodoxin reductases (ferredoxin YP_691867.1 proposed to catalyze the late steps in adenosylcobalamin biosynthesis, which define the nucleotide loop assembly pathway. YP_691868.1 catalyze the reversible hydration of alpha, beta-unsaturated enoyl-CoA substrates to the corresponding beta-hydroxyacyl-CoA products YP_691869.1 unkown YP_691870.1 unknown YP_691871.1 unknown YP_691875.1 COG: ABC-type Zn2+ transport system, periplasmic component/surface adhesin YP_691876.1 COG: ABC-type Mn/Zn transport systems, ATPase component YP_691880.1 protein transport. YP_691882.1 rubredoxin and rubredoxin reductase (reduces rubredoxin + nad(+) = oxidized rubredoxin + nadh) YP_691883.1 rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. its single fe, chelated to 4 cys, functions as an electron acceptor and may also stabilize the conformation of the molecul YP_691884.1 catalyses the first step in ubiquinone synthesis, i.e. the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate. YP_691885.1 catalyzes the attachment of prenyl lipid anchors to the carboxyl termini of a variety of proteins. YP_691886.1 This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by phoB and phoR when phosphate is limited. YP_691887.1 Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. phoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals. YP_691888.1 RecG-like helicase YP_691889.1 Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. oxyR expression is negatively autoregulated by binding to a 43 bp region upstream of its own coding sequence. oxyR is inactivated by reduction of its essential disulfide bond by the product of grxA, itself positively regulated by oxyR. Has also a positive regulatory effect on the production of surface proteins that control the colony morphology and auto-aggregation ability. YP_691891.1 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase YP_691892.1 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) YP_691895.1 tRNA degradation YP_691896.1 Guanosine polyphosphate pyrophosphohydrolases YP_691897.1 Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo YP_691898.1 catalyzes the ATP-dependent phosphorylation of GMP into GDP YP_691900.1 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O. YP_691904.1 Synthesis of Acyl-CoA YP_691905.1 catalyzes the first step in oxidation of fatty acids YP_691906.1 catalyzes the first step in oxidation of fatty acids YP_691913.1 unknown YP_691915.1 hydrolysis of water soluble or insoluble esters, including triglycerides YP_691918.1 transcriptional regulator YP_691919.1 transcriptional regulator YP_691923.1 acting on iron-sulfur proteins as donors with NAD+ or NADP+ as acceptor YP_691926.1 {trna}(n+1) + phosphate = {trna}(n) + a nucleoside diphosphate YP_691927.1 biosynthesis of pyrimidine nucleotides: Alpha-D-ribosyldiphosphate 5-phosphate (PRPP) and orotate are utilized to form pyrophosphate and orotidine 5'-monophosphate YP_691929.1 regulation of transcription YP_691930.1 ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. YP_691931.1 d-mannose 1-phosphate = d-mannose 6-phosphate / d-glucose 1-phosphate = d-glucose 6-phosphate. YP_691932.1 dUTPase YP_691933.1 flavoprotein affecting synthesis of dna and pantothenate metabolism YP_691934.1 involved in dna repair YP_691947.1 involved in the transposition of the insertion sequences. YP_691948.1 unknown YP_691952.1 High-affinity uptake of choline driven by a proton- motive force. Pathway: osmoregulatory choline-glycine betaine pathway. YP_691957.1 unknown YP_691958.1 directed movement of substances YP_691969.1 responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. YP_691973.1 Formation of acetoacetyl-CoA from two molecules of acetyl-CoA. YP_691974.1 permease YP_691976.1 s-adenosyl-l-methionine + 8-amino-7-oxononanoate = s-adenosyl-4-methylthio-2-oxobutanoate + 7,8- diaminononanoate YP_691981.1 unknown YP_691983.1 catalytic activity ATP + l-glutamate + l-cysteine = ADP + phosphate + gamma-l-glutamyl-l-cysteine. YP_691985.1 FOG YP_691986.1 unctions as a cation/drug antiporter (by similarity). YP_691988.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_691989.1 Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF & ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals. YP_691990.1 catalyzes the cleavage of the glycosidic bonds between n-acetylmuramic acid and n- acetylglucosamine residues in peptidoglycan YP_691994.1 transfer of electrons from nadh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone. does not couple the redox reaction to proton translocation YP_691995.1 atp + oxaloacetate = adp + phosphoenolpyruvate + co(2) YP_691996.1 Disulfide bond chaperones of the HSP33 family YP_691997.1 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit YP_691998.1 Predicted hydrolase YP_691999.1 active on adenosine(5')triphospho(5')adenosine (ap3a), adp-ribose, nadh, adenosine(5')diphospho(5')adenosine (ap2a) (adp-ribose + h(2)o = amp + d-ribose 5- phosphate) YP_692000.1 could help control the pool of 3'-phosphoadenoside 5'-phosphosulfate, or its use in sulfite synthesis YP_692013.1 unknown YP_692014.1 catalyzes the last step in heme biosynthesis: the chelation of a ferrous ion to proto-porphyrin IX, to form protoheme (protoporphyrin + fe(2+) = protoheme + 2 h(+)) YP_692016.1 isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH. YP_692018.1 responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. YP_692022.1 It oxidizes pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P YP_692024.1 unknown YP_692025.1 binds specifically to the ssra RNA (tmRNA) and is required for stable association of ssra with ribosomes YP_692028.1 may have a structural role in maintaining the cell envelope integrity YP_692030.1 May be involved in recombinational repair of damaged DNA. YP_692032.1 Transcriptional regulator of heat shock gene YP_692033.1 The GrpE protein functions with the DnaK and DnaJ proteins to prevent the aggregation of newly synthesized proteins and of unfolded proteins that arise as a consequence of cell stress. YP_692034.1 The DnaK protein functions with the GrpE and DnaJ proteins to prevent the aggregation of newly synthesized proteins and of unfolded proteins that arise as a consequence of cell stress. YP_692035.1 The DnaJ protein functions with the GrpE and DnaK proteins to prevent the aggregation of newly synthesized proteins and of unfolded proteins that arise as a consequence of cell stress. YP_692036.1 2,3,4,5-tetrahydrodipicolinate + NAD(P)(+) = 2,3-dihydrodipicolinate + NAD(P)H. YP_692037.1 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. YP_692038.1 2 ATP + L-glutamine + CO(2) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. YP_692039.1 Transcription elongation factor YP_692041.1 specifically methylates the uridine in position 2552 of 23s rrna in the 50s particle (s-adenosyl-l-methionine + rrna = s-adenosyl-l- homocysteine + rrna containing 2'-o-methyluridine) YP_692042.1 involved in the degradation of sigma-32. degrades carboxy- terminal-tagged cytoplasmic proteins YP_692043.1 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropt eridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate YP_692044.1 catalyses the interconversion of glucosamine-6-phosphate into glucosamine-1-phosphate in the biosynthetic pathway leading to the synthesis of UDP-N-acetylglucosamine YP_692045.1 d-glyceraldehyde 3-phosphate = glycerone phosphate. YP_692048.1 participates in both the termination and antitermination of transcription. interacts with rna polymerase and binds rna (by similarity). YP_692049.1 protects formylmethionyl-trna from spontaneous hydrolysis and promotes its binding to the 30s ribosomal subunits. also involved in the hydrolysis of gtp during the formation of the 70s ribosomal complex YP_692050.1 essential for efficient processing of 16s rrna. may interact with the 5'terminal helix region of 16s rrna YP_692051.1 formation of pseudouridine at position 55 in the psi gc loop of transfer rnas (uracil + d-ribose 5-phosphate = pseudouridine 5'-phosphate + h(2)o) YP_692052.1 This protein is one of the 16S ribosomal RNA binding proteins. Functions at early steps in ribosome assembly. YP_692053.1 involved in mrna degradation. hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction ({rna}(n+1) + phosphate = {rna}(n) + a nucleoside diphosphate) YP_692054.1 synthesis of acetyl-CoA from CO, CoA, and a methyl group YP_692055.1 catalytic activity: l-aspartate = beta-alanine + co(2). cofactor: pyruvoyl group (by similarity). pathway: pantothenate biosynthesis; second branch. similarity belongs to the pand family. YP_692056.1 atp + (r)-pantoate + beta-alanine = amp + diphosphate + (r)-pantothenate YP_692057.1 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate YP_692058.1 catalyses production of deoxynucleotide 5'-monophosphate from a deoxynucleoside YP_692059.1 atp + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = amp + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pterid ine YP_692060.1 Polymerase that creates the 3'poly(A) tail found in some mRNA's. Seems to be involved in plasmid copy number control. Catalytic activity: n ATP + {nucleotide}(m) = n diphosphate + {nucleotide}(m+n). YP_692061.1 Response regulator containing CheY YP_692063.1 unknown YP_692064.1 COG: Glutamyl- and glutaminyl-tRNA synthetases YP_692065.1 DnaK suppressor protein YP_692067.1 The sugar fermentation stimulation protein is a probable regulatory factor involved in maltose metabolism YP_692070.1 phosphorylates sugars in the presence of ATP and magnesium YP_692073.1 Uncharacterized conserved protein YP_692074.1 (s)-4-amino-5-oxopentanoate = 5-aminolevulinate YP_692075.1 catalyzes the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-hydroxyethyl)thiazole phosphate to yield thiamine phosphate in the thiamine biosynthesis pathway YP_692076.1 catalyzes the phosphorylation of hmp-p to hmp-pp (atp + 4-amino-2-methyl-5- phosphomethylpyrimidine = adp + 4-amino-2-methyl-5- diphosphomethylpyrimidine) YP_692079.1 catalyses the NADPH-dependent reduction of N-acetyl-gamma-glutamyl phosphate to give the N-acetylglutamic semialdehyde YP_692081.1 Integral membrane protein CcmA involved in cell shape determination YP_692083.1 unknown YP_692086.1 atp + l-tyrosine + trna(tyr) = amp + diphosphate + l-tyrosyl-trna(tyr) YP_692087.1 catalyses the formation of fatty acyl-CoA YP_692088.1 transcription factor activity YP_692090.1 unknown YP_692091.1 GTPases YP_692093.1 Transcription antiterminator YP_692094.1 This protein binds directly to 23S ribosomal RNA. YP_692095.1 This protein binds directly to 23S ribosomal RNA and is located in the neighborhood of the site where elongation factor tu is bound to the ribosome. function protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. YP_692096.1 Protein L10 is also a translational repressor protein, it controls the translation of the rpljl-rpoBC operon by binding to its mRNA. YP_692097.1 Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation. YP_692098.1 DNA-directed RNA polymerase beta subunit/140 kD subunit (split gene in Mjan, Mthe, Aful) YP_692099.1 DNA-directed RNA polymerase beta' subunit/160 kD subunit (split gene in archaea and Syn) YP_692100.1 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the a site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, It traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins s8, s12 and s17 appears to hold together the shoulder and platform of the 30S subunit (by similarity). YP_692101.1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, where it has been shown to contact mRNA. Probably blocks exit of the e-site tRNA (by similarity). Protein S7 is also a translational repressor protein; it regulates the expression of the str operon members to different degrees by binding to its mRNA. YP_692102.1 This protein promotes the GTP-dependent translocation of the nascent protein chain from the a-site to the p-site of the ribosome. YP_692103.1 this protein promotes the gtp-dependent binding of aminoacyl-trna to the a-site of ribosomes during protein biosynthesis YP_692104.1 produces a precursor for alginate polymerization. gdp-mannose + 2 nad(+) + h(2)o = gdp-d-mannuronate + 2 nadh. YP_692107.1 involved in regulation of the exopolysaccharide alginate biosynthesis YP_692108.1 Involved in the export of the exopolysaccharide alginate YP_692109.1 AlgI is involved in acetylation of the alginate polymer. YP_692110.1 AlgJ is involved in acetylation of the alginate polymer YP_692111.1 AlgF is involved in acetylation of the alginate polymer YP_692113.1 depolymerisation of alginates by beta -elimination, generating a molecule containing 4-deoxy-L-erythro-hex-4-enepyranosyluronate at the nonreducing end YP_692115.1 produces a precursor for alginate polymerization. catalitic activity: d-mannose 6-phosphate = d-fructose 6- phosphate. gdp + d-mannose 1-phosphate = phosphate + gdp- mannose. YP_692116.1 Involved in the binding of tRNA to the ribosomes. YP_692117.1 This protein binds directly to 23S ribosomal RNA and may participate in the formation of the peptidyltransferase center of the ribosome. YP_692118.1 This protein binds directly and specifically to 23S rRNA. Protein L4 is also a translational repressor protein, it controls the translation of the S10 operon (to which belong L4) by binding to its mRNA YP_692119.1 Binds to a specific region on the 23S rRNA. YP_692120.1 This protein is a primary 23S rRNA-binding protein. It has peptidyltransferase activity. YP_692121.1 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_692122.1 This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S reconstitution. YP_692123.1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation. YP_692124.1 This protein binds directly to 23S ribosomal RNA and is located at the a site of the peptidyltransferase center. YP_692125.1 Ribosomal protein L29 YP_692126.1 Protein S17 binds specifically to the 5' end of 16s ribosomal RNA. S17 is thought to be involved in the recognition of termination codons. YP_692127.1 This protein binds directly to 23S ribosomal RNA. YP_692128.1 This protein is found in the ribonucleoprotein core and is involved in the early assembly of the 50S subunit. It is not involved in the functions of the mature 50S subunit. YP_692129.1 This is one of 3 proteins that mediate the attachment of the 5S RNA into the large ribosomal subunit. YP_692130.1 Known to be required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16s rRNA at the a site. YP_692131.1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_692132.1 This protein binds directly to 23S ribosomal RNA and is located at the aminoacyl-tRNA binding site of the peptidyltransferase center. YP_692133.1 This is one of 3 proteins that mediate the attachment of the 5S RNA into the large ribosomal subunit YP_692134.1 In E.coli and S.typhimurium has been shown, with S4 and S12, to play an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations). YP_692135.1 Ribosomal protein L30 YP_692136.1 This protein binds directly to 23S ribosomal RNA. YP_692137.1 Involved in protein export. Interacts with secA and secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel. subunit one of seven secretory proteins (seca-f & secy) that comprise the prokaryotic protein translocation apparatus. YP_692138.1 Ribosomal protein L36 YP_692139.1 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the E.coli 70S ribosome it has been modeled to contact the 23S rRNA (bridge b1a) and protein L5 of the 50S subunit (bridge b1b), connecting the 2 subunits; these bridges are implicated in subunit movement. contacts the tRNAs in the a and p-sites. Subunit: part of the 30S ribosomal subunit. forms a loose heterodimer with protein S19. forms two bridges to the 50S subunit in the 70S ribosome. YP_692140.1 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. forms part of the shine-dalgarno cleft in the 70S ribosome. Subunit: part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Cross-links to if-3. YP_692141.1 One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations). YP_692141.1 Protein S4 is also a translational repressor protein, it controls the translation of the alpha-operon (which codes for S13, S11, S4, RNA polymerase alpha subunit, and L17) by binding to its mRNA. Also functions as a rho-dependent antiterminator of rRNA transcription, increasing the synthesis of rRNA under conditions of excess protein, allowing a more rapid return to homeostasis. Binds directly to RNA polymerase. YP_692142.1 DNA-directed RNA polymerase alpha subunit/40 kD subunit YP_692143.1 Ribosomal protein L17 YP_692147.1 the uvrabc repair system catalyzes the recognition and processing of DNA lesions. uvra is an ATPase and a DNA-binding protein. a damage recognition complex composed of 2 uvra and 2 uvrb subunits scans DNA for abnormalities. when the presence of a lesion has been verified by uvrb, the uvra molecules dissociate. YP_692148.1 Function unclear YP_692150.1 This protein is essential for replication of the chromosomes and its single-stranded DNA phages. It is also involved in DNA recombination and repair. YP_692153.1 involved in a general secretion pathway (gsp) for the export of proteins YP_692155.1 Adenylate cyclase YP_692158.1 Nitroreductase YP_692160.1 MoxR YP_692167.1 unknown YP_692168.1 unknown YP_692172.1 This protein binds to 23S ribosomal RNA in the presence of protein L20. YP_692173.1 Ribosomal protein L27 YP_692175.1 catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline. ATP + L-glutamate = ADP + L-glutamate 5-phosphate. YP_692176.1 Binds directly to 16S ribosomal RNA. YP_692178.1 atp + riboflavin = adp + fmn / atp + fmn = diphosphate + fad YP_692179.1 atp + l-isoleucine + trna(ile) = amp + diphosphate + l-isoleucyl-trna(ile). YP_692180.1 Lipoprotein signal peptidase YP_692182.1 catalyses the conversion of 1-hydroy-2-methyl-2-(E)-butenyl 4-diphosphate into IPP (isopentenyl diphosphate) and DMAPP (dimethylallyl diphosphate) YP_692183.1 involved in biogenesis. YP_692187.1 Tfp pilus assembly protein YP_692188.1 Tfp pilus assembly protein PilE YP_692194.1 catalyzes the last step in the biosynthesis of nicotinamide adenine dinucleotide and is induced by stress factors such as heat shock and glucose limitation YP_692196.1 responsible for synthesis of pseudouridine from uracil at two positions in 23s ribosomal RNA (uracil + d-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O YP_692201.1 2 pyruvate = 2-acetolactate + CO(2). YP_692202.1 2 pyruvate = 2-acetolactate + CO(2). YP_692205.1 (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. YP_692206.1 catalyzes the formation of unsaturated archaetidylserine from CDP-unsaturated archaeol and L-serine YP_692208.1 unknown YP_692212.1 ATP + l-Valine + tRNA(Val) = AMP + diphosphate + l-Valyl-tRNA(Val) YP_692214.1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (by similarity). Catalytic activity: n deoxynucleoside triphosphate = n diphosphate + {dna}(n). YP_692215.1 presumably involved in the processing and regular turnover of intracellular proteins. catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. release of an N-terminal amino acid, xaa-|- xbb-, in which xaa is preferably leu, but may be other amino acids including pro although not arg or lys, and xbb may be pro. YP_692220.1 synthesizes oq from preq1 in a single s-adenosylmethionine-requiring step. the ribosyl moiety of adomet is transferred and isomerized to the epoxycyclopentane residue of oq YP_692221.1 trna guanine + queuine = trna queuine + guanine YP_692223.1 Involved in protein export. Subunit: part of the prokaryotic protein translocation apparatus which comprise secA, secB, secD, secE, secF, secG and secY. YP_692224.1 Involved in protein export. subunit part of the prokaryotic protein translocation apparatus which comprise secA, secB, secD, secE, secF, secG and secY. YP_692230.1 tdh has multiple catalytic activities. apart from catalyzing the oxidation of (+)-tartrate to oxaloglycolate, also converts meso-tartrate to D-glycerate and catalyzes the oxidative decarboxylation of D-malate to pyruvate. tartrate + NAD(+) = oxaloglycolate + NADH. YP_692231.1 succinate semialdehyde + nad(p)(+) + h(2)o = succinate + nad(p)h YP_692232.1 biosynthesis of free myo-inositol from inositol-1-phosphate YP_692234.1 acetyl-CoA + L-serine = CoA + O-acetyl-L-serine. YP_692236.1 n-substituted aminoacyl-tRNA + H(2)O = n-substituted amino acid + tRNA YP_692237.1 Binds to the 5S rRNA YP_692238.1 ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. YP_692239.1 catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2c-methyl-d-erythritol (by similarity). atp + 4-(cytidine 5'-diphospho)-2-c-methyl-d- erythritol = adp + 2-phospho-4-(cytidine 5'-diphospho)-2-c-methyl- d-erythritol. YP_692241.1 probably mediates protein-protein interactions YP_692242.1 glutamyl-trna(glu) + nadph = glutamate-1-semialdehyde + nadp(+) + trna(glu) YP_692243.1 peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons uag and uaa YP_692244.1 methylates the translation YP_692246.1 catalyze the reversible hydration of alpha, beta-unsaturated enoyl-CoA substrates to the corresponding beta-hydroxyacyl-CoA products YP_692247.1 Assembled with A and C subunitd =ATP + l-glutamyl-tRNA(gln) + l-glutamine = ADP + phosphate + l-glutaminyl-tRNA(gln) + l-glutamate YP_692248.1 Assembled with B and C subunits = ATP + l-glutamyl-tRNA(gln) + l-glutamine = ADP + phosphate + l-glutaminyl-tRNA(gln) + l-glutamate YP_692249.1 Assembled with A and B subunits =ATP + l-glutamyl-tRNA(gln) + l-glutamine = ADP + phosphate + l-glutaminyl-tRNA(gln) + l-glutamate YP_692250.1 involved in formation of the rod shape of the cell. may act as a negative regulator of ftsi YP_692251.1 involved in formation of the rod shape of the cell. may also contribute to regulation of formation of penicillin-binding proteins YP_692252.1 involved in the rod shape determination YP_692253.1 inhibitor of septum formation YP_692255.1 hydrolase, acting on carbon-nitrogen YP_692256.1 suppresses the inhibitory activity of the carbon storage regulator (csra) YP_692260.1 possible gene required for the production of an antibiotic peptide YP_692261.1 transport of magnesium YP_692263.1 this is a second nitrate reductase enzyme which can substitute for the nra enzyme and allows e.coli to use nitrate as an electron acceptor during anaerobic growth. the gamma chain is a membrane-embedded heme-iron unit resembling cytochrome b, which transfers electrons from quinones to the beta subunit. nitrite + acceptor = nitrate + reduced acceptor. YP_692264.1 required for the assembly of the nitrate reductase- cytochrome b-nr complex to be fully active in the membrane. nitrite + acceptor = nitrate + reduced acceptor. YP_692265.1 this is a second nitrate reductase enzyme which can substitute for the nra enzyme and allows e.coli to use nitrate as an electron acceptor during anaerobic growth. the beta chain is an electron transfer unit containing four cysteine clusters involved in the formation of iron-sulfur centres. electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit. nitrite + acceptor = nitrate + reduced acceptor. YP_692266.1 second nitrate reductase enzyme which can substitute for the nra enzyme and could allow to use nitrate as an electron acceptor during anaerobic growth YP_692268.1 nitrogen active -transport system YP_692272.1 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog YP_692273.1 Transport: unknown substrate YP_692275.1 unknown YP_692279.1 probably a part of toluene transporter system YP_692280.1 cell wall formation. adds enolpyruvyl to udp-n-acetylglucosamine (phosphoenolpyruvate + udp-n-acetyl-d-glucosamine = phosphate + udp-n-acetyl-3-o-(1-carboxyvinyl)-d- glucosamine) YP_692281.1 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose-1-diphosphate. YP_692282.1 catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. L-histidinol + 2 NAD(+) + H(2)O = L-histidine + 2 NADH. YP_692283.1 Histidinol-phosphate aminotransferase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme catalyzing a reversible transamination reaction between histidinol phosphate and 2-oxoglutarate to form imidazole acetol phosphate and glutamate. L-histidinol-phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. YP_692286.1 unknown YP_692287.1 unknown YP_692289.1 Predicted hydrolase of the alpha YP_692290.1 ATPase YP_692293.1 unknown YP_692296.1 This protein is one of the early assembly proteins of the 50S ribosomal subunit. YP_692297.1 Ribosomal protein S9 YP_692298.1 component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. qh(2) + 2 ferricytochrome c = q + 2 ferrocytochrome c. YP_692299.1 component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis YP_692300.1 component of the ubiquinol-cytochrome c reductase complex (complex iii or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to atp synthesis. c1 functions as an electron donor to cytochrome c. YP_692301.1 forms an equimolar complex with the rna polymerase holoenzyme (rnap) but not with the core enzyme, it is synthesized predominantly when cells are exposed to amino acid starvation, at which time it accounts for over 5046f the total protein synthesized. it is involved in the transition from p1 early to p1 late gene expression. rnk and sspa can functionally replace p.aeruginosa alginate regulatory gene algr2. YP_692302.1 Binding of SspB enhances degradation of tagged proteins by ClpX, and masks sequence elements important for ClpA interactions, inhibiting degradation by ClpA [1]. However, more recent work has cast doubt on the importance of SspB in wild-type cells [2]. SspB is encoded in an operon whose synthesis is stimulated by carbon, amino acid, and phosphate starvation. SspB may play a special role during nutrient stress, for example by ensuring rapid degradation of the products of stalled translation, without causing a global increase in degradation of all ClpXP substrates YP_692302.1 stringent starvation protein B (SspB), is thought to enhance the specificity of degradation of tmRNA-tagged proteins by the ClpXP protease. The tmRNA tag, also known as ssrA, is an 11-aa peptide added to the C terminus of proteins stalled during translation, targets proteins for degradation by ClpXP and ClpAP. SspB a cytoplasmic protein that specifically binds to residues 1-4 and 7 of the tag. YP_692304.1 involved in synthesis of glyceromannoheptose 7-phosphate (by similarity). YP_692305.1 unknown YP_692307.1 This family uses S-AdoMet in the methylation of diverse substrates YP_692312.1 responsible for the final stages of peptidoglycan biosynthesis for cell wall formation YP_692313.1 UDP-N-acetylmuramyl tripeptide syntethase YP_692314.1 D-alanyl-D-alanine-adding enzyme YP_692315.1 UDP-MurNAc-pentapeptide phosphotransferase YP_692316.1 D-glutamic acidadding enzyme YP_692317.1 Bacterial cell division membrane protein YP_692318.1 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase YP_692319.1 UDP-N-acetylmuramoyl-L-alanine synthetase YP_692320.1 D-alanylalanine synthetase YP_692321.1 This protein may be involved in septum formation. YP_692322.1 this protein may be involved in anomalous filament growth (by similarity). may be a component of the septum. it may interact with ftsz. YP_692323.1 This protein is essential to the cell-division process. It seems to assemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur, and the formation of the ring is the signal for septation to begin. Binds to and hydrolyzes GTP. YP_692324.1 involved in the biosynthesis of lipid a, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (udp-3-o-(3-hydroxytetradecanoyl)-n- acetylglucosamine + h(2)o = udp-3-o-(3-hydroxytetradecanoyl)- glucosamine + acetate) YP_692327.1 Involved in protein export. Interacts with the secY/secE subunits. SecA has a central role in coupling the hydrolysis of ATP to the transfer of pre-secretory periplasmic and outer membrane proteins across the membrane. Subunit: part of the prokaryotic protein translocation apparatus which comprise secA, secB, secD, secE, secF, secG and secY. YP_692328.1 catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetlyglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate. N(2)-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-l-glutamate. acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate. YP_692329.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_692330.1 Function unknown YP_692331.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme a to form coenzyme a (atp + dephospho-coa = adp + coa ) YP_692332.1 cleaves type-4 fimbrial leader sequence and methylates the n-terminal (generally phe) residue. processes the tapa pilin precursor during membrane translocation. YP_692333.1 involved in the translocation of the type iv pilin YP_692334.1 involved in the translocation of the type iv pilin (pila) YP_692335.1 cell adhesion YP_692337.1 nicotinate d-ribonucleotide + diphosphate + co(2) = pyridine-2,3-dicarboxylate + 5-phospho-alpha-d-ribose 1- diphosphate YP_692338.1 protein responsible for alanine transport. uses sodium cations as coupling cations for cotransport. YP_692340.1 participates in the intracellular recycling of peptidoglycan fragments YP_692342.1 the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa & co(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) & lipoamide dehydrogenase (e3) (by similarity). pyruvate + lipoamide = s-acetyldihydrolipoamide + co(2). YP_692343.1 the pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-coa and co(2). it contains multiple copies of three enzymatic components: pyruvate dehydrogenase (e1), dihydrolipoamide acetyltransferase (e2) and lipoamide dehydrogenase (e3). acetyl-coa + dihydrolipoamide = coa + s-acetyldihydrolipoamide. YP_692344.1 unknown YP_692349.1 Biosynthesis of cofactors, prosthetic groups, and carriers YP_692353.1 protein folding YP_692354.1 Protein folding YP_692355.1 RNA-directed DNA-polymerase YP_692356.1 Uncharacterized membrane protein (homolog of Drosophila rhomboid) YP_692358.1 catalyzes the condensation of the acetyl group of acetyl-coa with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Acetyl-CoA + 3-methyl-2-oxobutanoate + h(2)o = 2-hydroxy-2-isopropylsuccinate + CoA. YP_692363.1 increases the formation of ribosomal termination complexes and stimulates activities of rf-1 and rf-2. it binds guanine nucleotides and has strong preference for uga stop codons. it may interact directly with the ribosome. YP_692364.1 unknown YP_692366.1 unknown YP_692369.1 destroys radicals which are normally produced within the cells and which are toxic to biological systems (2 superoxide + 2 h(+) = o(2) + h(2)o(2)) YP_692376.1 3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH. YP_692379.1 Overexpression of polIV results in increased frameshift mutagenesis. It is required for stationary-phase adaptive mutation, which provides the bacterium with flexibility in dealing with environmental stress, enhancing long-term survival and evolutionary fitness. May be involved in translesional synthesis, in conjunction with the beta clamp from polIII. Catalytic activity: n deoxynucleoside triphosphate = n diphosphate + {dna}(n). YP_692379.1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3'-5' exonuclease (proofreading) activity. YP_692381.1 specifically methylates the guanosine in position 745 of 23s rrna (s-adenosyl-l-methionine + rrna = s-adenosyl-l- homocysteine + rrna containing n(1)-methylguanine) YP_692382.1 unknown YP_692384.1 Transcriptional activator YP_692395.1 transcriptional regulator YP_692396.1 Coenzyme F420 YP_692400.1 through the carboxylation of phosphoenolpyruvate (pep) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. phosphate + oxaloacetate = h(2)o + phosphoenolpyruvate + co(2). YP_692408.1 catalyze uptake of dicarboxylates in a H(+)- or Na(+)-dicarboxylate symport YP_692409.1 Exchange or efflux of C4-dicarboxylates YP_692410.1 catalyze uptake of dicarboxylates in a H(+)- or Na(+)-dicarboxylate symport YP_692414.1 may have an iron-responsive regulatory function. citrate = cis-aconitate + h(2)o. YP_692416.1 acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. YP_692417.1 transport system that facilitate potassium-efflux, possibly by potassium-proton antiport YP_692424.1 2 pyruvate = 2-acetolactate + CO(2). YP_692429.1 Unknown YP_692430.1 Ribonucleotide reductase YP_692431.1 catalyzes the reductive synthesis of deoxyribonucleotides YP_692432.1 Response regulators consisting of a CheY YP_692433.1 functions as a membrane-associated protein kinase that phosphorylates rsta YP_692434.1 key enzyme in the regulation of glycerol uptake and metabolism. Catalytic activity: ATP + glycerol = ADP + glycerol 3-phosphate. YP_692438.1 catalyzes the conversion of ornithine and carbamoyl phosphate (CP) into citrulline and inorganic phosphate in the de novo pathway for arginine biosynthesis and in the detoxifying urea cycle. carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. YP_692439.1 N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. YP_692440.1 hyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids. YP_692441.1 binds and carries Fe (3+) into the periplasmic space (in the presence of tonB protein) YP_692444.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (trna-c-c-a). Also appears to be involved in tRNA biosynthesis. YP_692445.1 ATP +L-citrulline +L-aspartate = AMP + diphosphate + L-argininosuccinate. YP_692446.1 catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (R)-S-lactoylglutathione = glutathione + methylglyoxal. YP_692448.1 responsible for the addition of glutamic acid residues to the c-terminus of ribosomal protein s6 YP_692450.1 forms adenosine 5'-phosphosulfate (APS) from ATP and free sulfate, the first step in the formation of the activated sulfate donor 3'-phosphoadenylylsulfate (PAPS) YP_692452.1 Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2 YP_692454.1 Superfamily II DNA and RNA helicases YP_692455.1 Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase. YP_692456.1 Transport of chromate. it reduces chromate accumulation and is essential for chromate resistance YP_692459.1 atp + l-proline + trna(pro) = amp + diphosphate + l-prolyl-trna(pro) YP_692463.1 Response regulator consisting of a CheY YP_692469.1 tp + l-aspartate + trna(asp) = amp + diphosphate + l-aspartyl-trna(asp). YP_692471.1 nuclease that resolves Holliday junction intermediates in genetic recombination. cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'terminal phosphate and a 3'terminal hydroxyl group YP_692472.1 the ruva-ruvb complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. ruvab is an helicase that mediates the Holliday junction migration by localized denaturation and reanneling. ruva stimulates, in the presence of DNA, the weak ATPase activity of ruvb YP_692473.1 the ruva-ruvb complex in the presence of atp renatures cruciform structure in supercoiled dna with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. ruvab is an helicase that mediates the holliday junction migration by localized denaturation and reanneling YP_692475.1 involved in the tonb-independent uptake of proteins YP_692476.1 involved in TonB-independent transport of various receptor bound substrates including colicins YP_692478.1 is an essential periplasmic component of the tol-dependent translocation system YP_692479.1 Outer membrane protein and related peptidoglycan YP_692485.1 transcriptional activator of the csg genes required for production of the curli (agf). YP_692486.1 This enzyme catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand, upon exposure to ultraviolet radiation. Catalytic activity: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). YP_692487.1 Acts on primary amines, and usually also on secondary and tertiary amines YP_692489.1 Cyclopropane fatty acid synthase and related methyltransferases YP_692490.1 catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate YP_692491.1 Zn YP_692496.1 L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H(2)O. YP_692498.1 catalyses the hydrolysis of beta-lactamase YP_692499.1 catalyzes the seventh step in the de novo purine biosynthetic pathway; the ATP-dependent conversion of 5'-phosphoribosyl-5-aminoimidazole-4-carboxylic acid and aspartic acid to phosphoribosylaminoimidazole-succinocarboxamide synthase YP_692502.1 Transcriptional regulators YP_692504.1 degrade murein via cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine YP_692505.1 Phosphoribosylformylglycinamidine (FGAM) synthase YP_692508.1 unknown YP_692511.1 NTP pyrophosphohydrolases including oxidative damage repair enzymes YP_692512.1 Carbonic anhydrases YP_692517.1 Necessary for efficient export of extra-cytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes. YP_692518.1 In addition to being a ribosomal protein, S16 also has a cation-dependent endonuclease activity. YP_692519.1 essential for efficient processing of 16s rrna. probably part of the 30s subunit prior to or during the final step in the processing of 16s free 30s ribosomal subunits. it could be some accessory protein needed for efficient assembly of the 30s subunit. it is needed in a step prior to rbfa during the maturation of 16s rrna. it has affinity for free ribosomal 30s subunits but not for 70s ribosomes (by similarity). YP_692520.1 is one of several nucleases operating together with the tRNA-modifying enzymes before the formation of the mature tRNA. It catalyses the reaction:S-adenosyl-L-methionine + tRNA -> S-adenosyl-L-homocysteine + tRNA containingN1-methylguanine, methylating guanosine(G) to N1-methylguanine (1-methylguanosine (m1G)) at position 37 of tRNAs that read CUN (leucine), CCN(proline), and CGG (arginine) codons. The presence of m1G improves the cellular growth rate and the polypeptide steptime and also prevents the tRNA from shifting the reading frame YP_692521.1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. YP_692523.1 Site-specific integrase/recombinase YP_692524.1 required for disulfide bond formation in some periplasmic proteins. also acts as a disulfide isomerase YP_692526.1 L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H. YP_692527.1 O-phospho-L-homoserine + H(2)O = L-threonine + phosphate. YP_692528.1 transporter activity YP_692529.1 unknown YP_692532.1 CoA transferase YP_692533.1 rRNA methylases YP_692536.1 reduction of the disulfide bond YP_692537.1 Alcohol dehydrogenase (ADH) catalyzes the reversible oxidation of ethanol to acetaldehyde with the concomitant reduction of NAD: YP_692542.1 has porin activity, forming small water-filled channels. also has a structural role in determining cell shape and ability to grow in low-osmolarity medium (by similarity) YP_692549.1 sensor histidine kinase YP_692551.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_692552.1 lator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcriptional regu YP_692554.1 catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-acp (acyl-[acyl-carrier protein] + malonyl-[acyl- carrier protein] = 3-oxoacyl-[acyl-carrier protein] + co(2) + [acyl-carrier protein]) YP_692555.1 necessary for the introduction of cis unsaturation into fatty acids. catalyzed the dehydration of (3r)-3-hydroxydecanoyl- acp to e-(2)-decenoyl-acp and then its isomerization to z-(3)- decenoyl-acp (by similarity). (3r)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl- carrier protein] + H(2)O. YP_692556.1 electron transport YP_692557.1 involved in the biogenesis of c-type cytochromes as well as in disulfide bond formation in periplasmic c-type cytochromes YP_692560.1 Adenylate kinase and related kinases YP_692562.1 may perform analogous functions in iron detoxification and storage to that of animal ferritins. YP_692564.1 lyase and sodium transporter YP_692565.1 lyase and sodium transporter (by similarity). oxaloacetate = pyruvate + co(2). YP_692573.1 probably part of a high-affinity binding-protein- dependent transport system for nitrate. probably responsible for energy coupling to the transport system YP_692575.1 ammonium hydroxide + 3 nad(p)(+) + h(2)o = nitrite + 3 nad(p)h YP_692579.1 Response regulator with antiterminator output domain YP_692581.1 metE catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. 5-methyltetrahydropteroyltri-L-glutamate + L- homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. YP_692582.1 control of the last step in methionine biosynthesis; metr is a positive activator of the meta, mete and meth genes. metr is also a negative regulator of its own expression. binds homocysteine as an inducer YP_692590.1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. YP_692591.1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. YP_692592.1 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes. YP_692593.1 Required for the biogenesis of c-type cytochromes. possible subunit of a heme lyase (by similarity). YP_692594.1 Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase. YP_692597.1 catalyzes the isomerization of 2 and 3-phosphoglycerates, and are essential for glucose metabolism YP_692598.1 probably involved in the export of a complex carbohydrate like a cell-surface polysaccharide or aminoglycoside antibiotics YP_692599.1 probably involved in the export of a complex carbohydrate like a cell-surface polysaccharide or aminoglycoside antibiotics YP_692601.1 cryptic, but when expressed on a high copy number plasmid, or when expressed at higher levels due to mutation, it allows utilization of p-aminobenzoyl-glutamate as a source of p-aminobenzoate for p-aminobenzoate auxotrophs YP_692608.1 unknown YP_692620.1 cell wall formation. the enzyme has a penicillin- insensitive transglycosylase n-terminal domain (formation of linear glycan strands) and a transpeptidase c-terminal domain which may not be functional. YP_692621.1 Anaerobic dehydrogenases YP_692622.1 Bacterial lipocalin YP_692623.1 involved in biosynthesis of an unidentified cell surface polysaccharide YP_692624.1 unknown YP_692625.1 involved in the export of an unidentified cell surface polysaccharide YP_692626.1 Protein YP_692627.1 Involved in biosynthesis or export of an unidentified cell surface polysaccharide YP_692628.1 oxidation of an alcohol to an acid YP_692630.1 dtdp-glucose = dtdp-4-dehydro-6-deoxy-d-glucose + h(2)o. YP_692631.1 dtdp-6-deoxy-l-mannose + nadp(+) = dtdp-4-dehydro-6-deoxy-l-mannose + nadph. YP_692633.1 dttp + alpha-d-glucose 1-phosphate = diphosphate + dtdp-glucose. YP_692634.1 dtdp-4-dehydro-6-deoxy-d-glucose = dtdp-4-dehydro-6-deoxy-l-mannose. YP_692635.1 involved in the export of an unidentified cell surface polysaacharide YP_692638.1 Glycosyltransferases involved in cell wall biogenesis YP_692639.1 Predicted glycosyltransferases YP_692640.1 Predicted glycosyltransferases YP_692645.1 Sugar transferases involved in lipopolysaccharide synthesis YP_692646.1 involved in the biosynthesis of lipid a, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (by similarity) YP_692647.1 Predicted pyridoxal phosphate YP_692648.1 Polysaccharides biosynthesis YP_692649.1 possibly involved in transmembrane transportation YP_692650.1 phosphorylation of adenylylsulphate (APS) to 3'-phosphoadenylylsulfate (PAPS) YP_692651.1 unknown YP_692652.1 provides UDPglucuronate, a precursor of cell surface polysaccharides YP_692654.1 may play a role in stationary phase survival. YP_692655.1 Provides a sugar nucleotide precursor involved in the biosynthesis of cell surface polysaccharides YP_692656.1 d-glucose 6-phosphate = d-fructose 6-phosphate. YP_692657.1 d-mannose 1-phosphate = d-mannose 6-phosphate. YP_692658.1 udp-glucose = udp-galactose. YP_692659.1 possilby involved in export or polymerization of an unidentified polysaccharide YP_692661.1 Glycosyltransferases involved in cell wall biogenesis YP_692662.1 involved in cell wall biogenesis YP_692664.1 L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. YP_692665.1 Helicase subunit of the DNA excision repair complex YP_692667.1 plays an important role in chromosome structure and partitioning. essential for chromosome partition. YP_692668.1 Interacts directly with the cell division protein ftsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane (by similarity). YP_692669.1 This protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. Catalytic activity: NAD(+) + {deoxyribonucleotide}(n) + {deoxyribonucleotide}(m) = AMP + nicotinamide nucleotide + {deoxyribonucleotide}(n+m). YP_692673.1 stereospecific condensation of phosphoenolpyruvate (pep) and D-erythrose-4-phosphate (e4p) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). phosphoenolpyruvate + D-erythrose-4-phosphate + H(2)O = 3-deoxy-D-erythro-hept-2-ulosonate 7-phosphate + phosphate. YP_692676.1 catalyzes the isomerization of 2 and 3-phosphoglycerates, and are essential for glucose metabolism YP_692682.1 oxidize a wide variety of aliphatic and aromatic aldehydes using NADP as a cofactor YP_692684.1 drug resistence, cation/drug antiporter (by similarity). YP_692685.1 probably involved in detoxification YP_692686.1 Transcriptional regulator YP_692687.1 AbpA catalyses the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway YP_692700.1 oxidoreductase YP_692703.1 thiolytic cleavage of beta-ketoadipyl-coa to succinate and acetyl-coa YP_692704.1 catalyzes the oxidative decarboxylation of glutaryl-CoA YP_692705.1 Synthesis of Acyl-CoA YP_692706.1 catalyzes the formation of malonyl-CoA, the C2 donor for de novo synthesis of long-chain fatty acids YP_692707.1 (3s)-3-hydroxyacyl-coa = trans-2(or 3)-enoyl-coa + h(2)o YP_692709.1 catalyzes the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA YP_692715.1 synthesis of NADP which is essential for biosynthetic pathways YP_692718.1 aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation. release of an N-terminal amino acid, xaa-|-xbb- from a peptide, amide or arylamide. xaa is preferably ala, but may be most amino acids including pro (slow action). when a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact xaa-pro dipeptide. YP_692723.1 catalyzes the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate YP_692724.1 This protein associates with 70s ribosomes and converts them to a dimeric form (100S ribosomes) which appear during the transition from the exponential growth phase to the stationary phase of Escherichia coli cells. YP_692727.1 Mg-dependent DNase YP_692728.1 Uncharacterized protein conserved in bacteria YP_692729.1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the 16 bp palindromic sequence 5'-ctgt-at(4)-acag-3'. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, leading to derepression of the SOS regulon and eventually DNA repair. Catalytic activity: hydrolysis of ala-|-gly bond in repressor lexA. YP_692731.1 Universal stress protein UspA and related nucleotide YP_692732.1 The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. Catalytic activity: ATP-independent breakage of single-stranded DNA, followed by passage and rejoining. YP_692733.1 Uncharacterized protein YP_692738.1 Hydrolysis of terminal non-reducing n- acetyl-d-hexosamine residues in n-acetyl-beta-d-hexosaminides. YP_692740.1 phosphoryl transfer reactions on activated form of ribose-5-phosphate YP_692741.1 Purine nucleoside phosphorylase YP_692742.1 Hemolysins and related proteins containing CBS domains YP_692743.1 O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate. YP_692748.1 Transcription-repair coupling factor (superfamily II helicase) YP_692749.1 hydrolyzing saturated and unsaturated acyl-CoA substrates YP_692751.1 glycolysis and gluconeogenesis by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho- glycerate YP_692752.1 nqr complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions,coupled with the transport of na(+) ions from the cytoplasm to the periplasm. nqra to nqre are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (by similarity). nadh + ubiquinone + na(+)(in) = nad(+) + ubiquinol + na(+)(out). YP_692753.1 nqr complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions,coupled with the transport of na(+) ions from the cytoplasm to the periplasm. nqra to nqre are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (by similarity). nadh + ubiquinone + na(+)(in) = nad(+) + ubiquinol + na(+)(out). YP_692754.1 nqr complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions,coupled with the transport of na(+) ions from the cytoplasm to the periplasm. nqra to nqre are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (by similarity). nadh + ubiquinone + na(+)(in) = nad(+) + ubiquinol + na(+)(out). YP_692755.1 nqr complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions,coupled with the transport of na(+) ions from the cytoplasm to the periplasm. nqra to nqre are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (by similarity). nadh + ubiquinone + na(+)(in) = nad(+) + ubiquinol + na(+)(out). YP_692756.1 nqr complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions,coupled with the transport of na(+) ions from the cytoplasm to the periplasm. nqra to nqre are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (by similarity). nadh + ubiquinone + na(+)(in) = nad(+) + ubiquinol + na(+)(out). YP_692757.1 nqr complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions,coupled with the transport of na(+) ions from the cytoplasm to the periplasm. the first step is catalyzed by nqrf, which accepts electrons from nadh and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (by similarity). nadh + ubiquinone + na(+)(in) = nad(+) + ubiquinol + na(+)(out). YP_692758.1 involved in thiamin biosynthesis YP_692760.1 unknown YP_692762.1 glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to g3p and the corresponding alcohols YP_692766.1 olase hydrolases that break carbon-nitrogen bonds YP_692768.1 unknown YP_692770.1 responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. YP_692772.1 Might contribute to transformation as a member of a membrane-bound pore complex at the base of the transformasome. It could directly interact with transforming DNA during translocation indirectly by participating in the assembly of the pore. YP_692773.1 Involved in the tonB-dependent energy-dependent transport of unidentified receptor-bound substrates. protects exbd from proteolytic degradation and functionally stabilizes tonb (by similarity) YP_692774.1 Involved in the tonB-dependent and energy-dependent transport of unidentified receptor-bound substrates YP_692775.1 Transfers the lipid A component of the lipopolysaccharides (LPS) to the outer face of the cell membrane YP_692776.1 Involved in the biosynthesis of the lipopolysaccharide component lipid A by transferring the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed ds-1- p) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVa) (by similarity). YP_692777.1 Involved in the biosynthesis of the lipopolysaccharide (LPS) component lipid A by activating KDO (a required 8-carbon sugar) (by similarity). YP_692778.1 Protein-tyrosine-phosphatase YP_692779.1 cell wall formation (by similarity). Catalytic activity: udp-n-acetylmuramate + nadp(+) = udp-n- acetyl-3-o-(1-carboxyvinyl)-d-glucosamine + nadph. YP_692780.1 matures 5s rrna from its precursors from all the rrna genes YP_692781.1 responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23s ribosomal rna (by similarity). Catalytic activity: uracil + d-ribose 5-phosphate = pseudouridine 5'-phosphate + h(2)o. YP_692782.1 hydrolase YP_692784.1 Nucleotide-binding protein implicated in inhibition of septum formation YP_692786.1 Ribosomal protein L32 YP_692787.1 not known, probably involved in fatty acid or phospholipid synthesis (by similarity). YP_692788.1 biosynthesis of fatty acids YP_692791.1 catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-acp (acyl-[acyl-carrier protein] + malonyl-[acyl- carrier protein] = 3-oxoacyl-[acyl-carrier protein] + co(2) + [acyl-carrier protein]) YP_692792.1 converts 4-amino-4-deoxychorismate into 4-aminobenzoate (paba) and pyruvate. Needs pyridoxal phosphate (by similarity) as cofactor. YP_692793.1 unknown YP_692794.1 catalyzes the phosphorylation ofthymidine 5'-monophosphate (dTMP) to thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium YP_692795.1 ATPase involved in DNA replication YP_692796.1 Tfp pilus assembly protein PilZ YP_692797.1 Mg-dependent DNase YP_692798.1 probably involved in dna recombination (by similarity) YP_692801.1 trasnferase YP_692803.1 Uncharacterized protein conserved in bacteria YP_692804.1 protein amino acid phosphorylation and ATP binding YP_692807.1 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases YP_692808.1 probable NAD(P)H-nitrite reductase YP_692809.1 oxidoreductase YP_692812.1 stereospecific condensation of phosphoenolpyruvate (pep) and D-erythrose-4-phosphate (e4p) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP). phosphoenolpyruvate + D-erythrose-4-phosphate + H(2)O = 3-deoxy-D-erythro-hept-2-ulosonate 7-phosphate + phosphate. YP_692813.1 NAD-dependent protein deacetylases, SIR2 family YP_692815.1 unknown YP_692816.1 unknown YP_692817.1 Predicted flavoprotein involved in K YP_692818.1 responsible for synthesis of pseudouridine from uracil-516 in 16s ribosomal rna. Catalytic activity: uracil + d-ribose 5-phosphate = pseudouridine 5'-phosphate + h(2)o. YP_692819.1 Transcriptional regulator YP_692820.1 accepts electrons from etf and reduces ubiquinone. reduced etf + ubiquinone = etf + ubiquinol. YP_692821.1 Electron transfer flavoprotein YP_692822.1 Electron transfer YP_692823.1 oxidoreductase YP_692826.1 unknown YP_692831.1 hydrolyzes saturated and unsaturated acyl-CoA substrates YP_692834.1 binds medium- and long-chain acyl-CoA esterswith high affinity, and may act as an intra-cellular carrier of acyl-CoA esters YP_692838.1 Septum formation topological specificity factor YP_692839.1 Septum formation inhibitor YP_692840.1 Septum formation inhibitor YP_692841.1 catalyzes the first step in oxidation of fatty acids YP_692843.1 P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents nr-ii catalyzed conversion of nr-i to nr-i-phosphate, the transcriptional activator of glnA. when P-II is uridylylated to P-II-UMP, these events are reversed. when the ratio of gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylylation of glutamine synthetase by glnE, so activating the enzyme. YP_692844.1 COG: Ammonia permease YP_692845.1 unknown YP_692846.1 links a guanosine 5'-phosphate to molydopterin (mpt) forming molybdopterin guanine dinucleotide (mgd) (by similarity). YP_692847.1 Rad3-related DNA helicases YP_692849.1 unknown YP_692850.1 confers resistance to bacitracin, probably by phosphorylation of undecaprenol. YP_692852.1 acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. YP_692857.1 N-succinyl-LL-2,6-diaminoheptanedioate + H(2)O = succinate + LL-2,6-diaminoheptanedioate. YP_692859.1 COG: Arsenate reductase and related proteins,glutaredoxin family YP_692861.1 modifies, by uridylylation or deuridylylation the pii (glnb) regulatory protein (by similarity) YP_692862.1 Mainrole: Protein fate. Subrole: Protein modification and repair. YP_692863.1 Ribosomal protein S2 YP_692864.1 Associates with the EF-TU.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- TU.GTP complex up to the GTP hydrolysis stage on the ribosome. YP_692865.1 Uridylate kinase catalyzes the phosphorylation of ump to udp YP_692866.1 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. YP_692867.1 Catalyzes the sequential cis-condensation of isopentenyl diphosphate (IPP) onto (E,E)-farnesyl diphosphate (FPP). YP_692868.1 catalyzes the formation of CDP-diacylglycerol YP_692869.1 catalyzes the nadp-dependent rearrangement and reduction of 1-deoxy-d-xylulose-5-phosphate (dxp) to 2-c-methyl-d-erythritol 4-phosphate (mep) (by similarity). 2-c-methyl-d-erythritol 4-phosphate + nadp(+) = 1-deoxy-d-xylulose 5-phosphate + nadph. YP_692874.1 involved in saturated fatty acids biosynthesis. YP_692875.1 involved in the biosynthesis of lipid a, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (by similarity) YP_692876.1 involved in the biosynthesis of the lipopolysaccharide (LPS) component lipd A YP_692877.1 This enzyme is an endonuclease that degrades the RNA of RNA-DNA hybrids specifically. Catalytic activity: endonucleolytic cleavage to 5'-phosphomonoester. YP_692878.1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase. Catalytic activity: n deoxynucleoside triphosphate = n diphosphate + {DNA}(n). subunit DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. YP_692878.1 This core dimerizes to form the polIII' complex. PolIII' associates with the gamma complex (composed of gamma,delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex. The final composition of the complex is: (alpha,epsilon,theta)[2]-tau[2]-(gamma,delta,delta', psi,chi)[2]-beta[4]. YP_692879.1 catalyzes carboxylation of acetyl-CoA to produce malonyl-CoA YP_692880.1 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_692881.1 Superfamily II DNA helicase YP_692882.1 catalyzes reaction: L-glutamine + H2O + UTP + ATP = CTP + phosphate + ADP + L-glutamate YP_692883.1 Lipopolysaccharide biosynthesis YP_692884.1 2-phospho-d-glycerate = phosphoenolpyruvate + H(2)O. YP_692885.1 Septum formation initiator YP_692886.1 catalyzes the formation of 4-diphosphocytidyl-2c-methyl- d-erythritol from ctp and 2c-methyl-d-erythritol 4-phosphate (by similarity). ctp + 2-c-methyl-d-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-c-methyl-d-erythritol. YP_692887.1 converts 4-diphosphocytidyl-2c-methyl-d-erythritol 2- phosphate into 2c-methyl-d-erythritol 2,4-cyclodiphosphate and cmp. also converts 4-diphosphocytidyl-2c-methyl-d-erythritol into 2c-methyl-d-erythritol 3,4-cyclophosphate and cmp (by similarity). YP_692889.1 catalyzes the methyl esterification of l-isoaspartyl residues in peptides and proteins (s-adenosyl-l-methionine + protein l-beta- aspartate = s-adenosyl-l-homocysteine + protein l-beta-aspartate methyl ester). it plays a role in the repair and/or degradation of damaged proteins (by similarity) YP_692893.1 unknown YP_692895.1 oxidation of alcohols to aldehydes or ketones YP_692897.1 erythronate-4-phosphate + NAD(+) = 3-hydroxy- 4-phospho-hydroxy-alpha-ketobutyrate + NADH. YP_692900.1 peptidase YP_692901.1 unknown YP_692912.1 ubiquinone production. YP_692913.1 methylation of lysine residues in histones and other proteins (by similarity). YP_692914.1 responsible for synthesis of pseudouridine from uracil- 746 in 23s ribosomal rna and position 32 in the anticodon stem and loop of transfer rnas (by similarity). Catalytic activity: uracil + d-ribose 5-phosphate = pseudouridine 5'-phosphate + h(2)o. YP_692915.1 degrades short-lived regulatory and abnormal proteins in presence of atp. hydrolyzes two atps for each peptide bond cleaved in the protein substrate (by similarity) YP_692919.1 unknown YP_692921.1 citrate = cis-aconitate + h(2)o YP_692922.1 myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA during lipopolysaccharide core biosynthesis, by sequence similarity YP_692923.1 synthesis of 2-methylthio-cis-ribozeatin in tRNA YP_692924.1 Lipid A biosynthesis, catalyzes the hydrolysis of the pyrophosphate bond of udp-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid x) and ump (by similarity) YP_692925.1 cis-trans isomerization of proline imidic peptide bonds in oligopeptide YP_692926.1 accelerates folding of proteins: catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_692927.1 atp + l-glutamine + trna(gln) = amp + diphosphate + l-glutaminyl-trna(gln). YP_692928.1 remethylation of homocysteine to methionine using methyltetrahydrofolate as cofactor YP_692929.1 ATP-independent chaperone YP_692930.1 Protease subunit of ATP YP_692931.1 atp-dependent specificity component of the clp protease. it directs the protease to specific substrates. can perform chaperone functions in the absence of clpp (by similarity). YP_692932.1 ATP-dependent Lon protease, bacterial type YP_692933.1 Bacterial nucleoid DNA-binding protein YP_692934.1 seems to be involved in the folding of outer membrane proteins YP_692935.1 acyl-[acyl-carrier protein] + nad(+) = trans-2,3-dehydroacyl-[acyl-carrier protein] + nadh. YP_692936.1 part of the binding-protein-dependent transport system for oligopeptides. probably responsible for energy coupling to the transport system. YP_692937.1 part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane. also required for sporulation and competence. YP_692938.1 part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane YP_692944.1 This enzyme is an endonuclease that degrades the RNA of RNA-DNA hybrids specifically. In E.coli RNAse H participates in DNA replication; it helps to specify the origin of genomic replication by suppressing initiation at origins other than the locus oric; along with the 5'-3' exonuclease of pol1, it removes RNA primers from the Okazaki fragments of lagging strand synthesis. YP_692945.1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contains the editing function and is a proofreading 3'-5' exonuclease. Catalytic activity. n deoxynucleoside triphosphate = n diphosphate + {dna}(n). Subunit DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. YP_692945.1 This core dimerizes to form the polIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta',psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex. The final composition of the complex is: (alpha,epsilon,theta)[2]-tau[2]-(gamma,delta,delta', psi,chi)[2]- beta[4]. YP_692948.1 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding YP_692950.1 multicopy suppressor of the htra (degp) null phenotype. it is possibly a protease, not essential for bacterial viability. YP_692951.1 catalyzes the reversible oxidation ofethanol to acetaldehyde with the concomitant reduction of NAD. YP_692953.1 Catalyzes the reversible conversion of tartronate semialdehyde into hydroxypyruvate YP_692956.1 Synthesis of acetyl-CoA from CO, CoA, and a methyl group YP_692957.1 catalyzes the formation of malonyl-CoA, the C2 donor for de novo synthesis of long-chain fatty acids YP_692958.1 catalyzes the reversible hydration of unsaturated enoyl-CoA substrates to the corresponding hydroxyacyl-CoA products YP_692959.1 catalyzes the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA YP_692960.1 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor YP_692961.1 Predicted transcriptional regulators YP_692962.1 unknown YP_692964.1 unknown YP_692965.1 converts dimethylmenaquinone (dmk) to menaquinone (mk) (by similarity). YP_692966.1 The exact function of CBSdomains is unknown,however it isthought that they bind to some as yet unidentified small molecule (perhaps with an adenosyl moiety) and regulate the activity of attached enzymatic or other domains. YP_692967.1 Predicted membrane protein YP_692968.1 malate + nad(+) = oxaloacetate + nadh YP_692971.1 catalyzes hydrolysis of several water-soluble esters to the corresponding free acid and alcohol. YP_692972.1 Stress YP_692973.1 involved in cyanide detoxification (by similarity). YP_692981.1 unknown YP_692986.1 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control YP_692987.1 acetyl-coa + h(2)o + glyoxylate = s-malate + coa YP_692993.1 Adenylosuccinate lyase YP_692994.1 unknown YP_692995.1 s-adenosyl-l-methionine + trna = s-adenosyl-l-homocysteine + trna containing 5-methylaminomethyl-2-thiouridylate. YP_692996.1 responsible for removing an oxidatively damaged form of guanine (8-hydroxy- guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency, leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate, with the concomitant release of pyrophosphate. YP_692997.1 together with moaA, is involved in the conversion of a guanosine derivative (gxp) into molybdopterin precursor z (by similarity). YP_692998.1 together with moaA, is involved in the conversion of a guanosine derivative (gxp) into molybdopterin precursor z (by similarity). YP_692999.1 converts molybdopterin precursor z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor z to generate a dithiolene group (by similarity). YP_693000.1 conversion of uracil bases to pseudouridine, by sequence similarity YP_693001.1 catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate YP_693002.1 catalyzes the oxidative decarboxylation of isocitrate into alpha -ketoglutarate YP_693003.1 Cold shock proteins YP_693004.1 unknown YP_693005.1 atp-dependent specificity component of the clpp protease. it directs the protease to specific substrates YP_693006.1 no specific function has so far been attributed to this initiation factor; however, it seems to stimulate more or less all the activities of the other two initiation factors, if-2 and if-3. YP_693009.1 thioredoxin + nadp(+) = thioredoxin disulfide + nadph. YP_693010.1 participaing in cell division YP_693011.1 Outer membrane lipoprotein YP_693013.1 unknown YP_693014.1 atp + l-serine + trna(ser) = amp + diphosphate + l-seryl-trna(ser). YP_693015.1 2 s-adenosyl-L-methionine + uroporphyrin iii = 2 s-adenosyl-L-homocysteine + sirohydrochlorin YP_693020.1 unknown YP_693021.1 Predicted ATPase involved in chromosome partitioning YP_693022.1 unknown YP_693023.1 Carbon starvation protein YP_693025.1 the uvrabc repair system catalyzes the recognition and processing of dna lesions. uvrc both incises the 5' and 3' sides of the lesion. the n-terminal half is responsible for the 3' incision and the c-terminal half is responsible for the 5' incision YP_693026.1 catalyses the biosynthesis of phosphatidylglycerol YP_693028.1 Methylase of chemotaxis methyl YP_693029.1 response regulator YP_693030.1 Chemotaxis response regulator containing a CheY YP_693042.1 unknown YP_693044.1 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine. YP_693045.1 Mechanosensitive ion channel YP_693047.1 the transhydrogenation between nadh and nadp is coupled to respiration and atp hydrolysis and functions as a proton pump across the membrane (by similarity). nadph + nad(+) = nadp(+) + nadh. YP_693049.1 the transhydrogenation between nadh and nadp is coupled to respiration and atp hydrolysis and functions as a proton pump across the membrane. nadph + nad(+) = nadp(+) + nadh. YP_693050.1 The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex and E. coli AarF is required for ubiquinone production. YP_693052.1 involved in the cleavage of a c-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (pbp3). may be involved in protection of the bacterium from thermal and osmotic stresses (by similarity). YP_693054.1 possibly reparation of alkylated DNA YP_693060.1 Universal stress protein UspA and related nucleotide YP_693061.1 cAMP YP_693062.1 anaerobic transformation of coproporphyrinogen-iii into protoporphyrinogen-ix. Requires magnesium, ATP and NAD (or NADP) for activity. YP_693067.1 involved in redox processes YP_693068.1 high potential cytochrome c believed to be an intermediate electron donor to terminal oxidation systems YP_693069.1 cytochrome c oxidase biogenesis YP_693070.1 high potential cytochrome c believed to be an intermediate electron donor to terminal oxidation systems YP_693071.1 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O YP_693072.1 catalyzes the reversible oxidation ofethanol to acetaldehyde with the concomitant reduction of NAD. YP_693073.1 unknown YP_693074.1 transposition regulatory protein YP_693075.1 probable transposase YP_693083.1 mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein copc. may have oxidase activity YP_693085.1 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain YP_693086.1 sensor histidine kinase YP_693088.1 involved in cation efflux across the cytoplasmic membrane. YP_693089.1 this protein specifically catalyzes the removal of signal peptides from prolipoproteins (by similarity). YP_693090.1 transcriptional regulator YP_693092.1 Growth regulator YP_693096.1 unknown YP_693100.1 hydrolase. YP_693105.1 AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. YP_693107.1 unknown YP_693108.1 Predicted transcriptional regulator containing the HTH domain YP_693110.1 atp + l-tryptophan + trna(trp) = amp + diphosphate + l-tryptophanyl-trna(trp). YP_693112.1 DNA-directed DNA polymerase. DNA replication. YP_693113.1 cell growth and/or maintenance YP_693120.1 de novo fatty acid biosynthesis, fatty acid chain termination YP_693124.1 sodium/hydrogen exchanger family protein YP_693125.1 Predicted transcriptional regulators YP_693128.1 sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor YP_693132.1 Repair of alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the o-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Can also repair o-4-methylthymine. The methylated ada protein acts as a positive regulator of its own synthesis,as well as that of other proteins. The transcription-activating function of the ada protein resides in its n-terminus. It activates the transcription of alkA, alkB and aidB. YP_693135.1 unknown YP_693136.1 unknown YP_693138.1 COG: Poly-beta-hydroxyalkanoate depolymerase YP_693142.1 ATPases involved in chromosome partitioning YP_693143.1 maintain high levels of reduced glutathione in the cytosol YP_693145.1 Bacterial lytic transglycosylases degrade murein via cleavage of the -1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine, with the concomitant formation of a 1,6-anhydrobond in the muramic acid residue. YP_693146.1 Oxidoreductase and electron transfer. The Rieske subunit acts by binding either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to the cytochrome c or cytochrome f haem iron YP_693147.1 atp + pyruvate + H(2)O = amp + phosphoenolpyruvate + phosphate. YP_693149.1 This family includes 2-methylcitrate dehydratas (PrpD) that is required for propionate catabolism. It catalyses the third step of the 2-methylcitric acid cycle. YP_693151.1 Citrate hydro-lyase YP_693152.1 catalyzes the synthesis of 2-methylcitrate from propionyl-coa and oxaloacetate (propanoyl-coa + h(2)o + oxaloacetate = (2r,3s)-2-hydroxybutane-1,2,3-tricarboxylate + coa) YP_693153.1 Catalyses the formation of C-P bonds YP_693154.1 Transcriptional regulators YP_693157.1 positive regulator of gene expression for the cysteine regulon YP_693164.1 catalyzes the exchange of initiation factor 2-bound gdp for gtp (by similarity). YP_693168.1 transferase YP_693169.1 ATP-dependent helicase HrpB YP_693172.1 unknown YP_693173.1 AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. YP_693174.1 converts O-succinylhomoserine into homocysteine. YP_693175.1 Glutamine phosphoribosylpyrophosphate amidotransferase YP_693176.1 toxin biosynthesis. YP_693178.1 Folylpolyglutamate synthetase catalyzes anATP-dependent ligation reaction that results in the synthesis of poly(gamma-glutamate) metabolites of folates and some antifolates YP_693179.1 catalyzes carboxylation of acetyl-CoA to produce malonyl-CoA YP_693180.1 the alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate. L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. YP_693181.1 the beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate. YP_693182.1 N-(5'-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. YP_693183.1 Pseudouridylate synthase (tRNA psi55) YP_693185.1 L-aspartate-4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH. YP_693186.1 L-aspartate-4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH. YP_693187.1 catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. the product decarboxylates to 4-methyl-2-oxopentanoate. 3-carboxy-2-hydroxy-4-methylpentanoate + NAD(+) = 3-carboxy-4-methyl-2-oxopentanoate + NADH. YP_693189.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. 3-isopropylmalate = 2-isopropylmaleate + H(2)O. 2-isopropylmaleate + H(2)O = 2-isopropylmalate. YP_693190.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. 3-isopropylmalate = 2-isopropylmaleate + H(2)O. 2-isopropylmaleate + H(2)O = 2-isopropylmalate. YP_693193.1 catalyzes the transformation of 5-enolpyruvylshikimate 3-phosphate to chorismate in the last step of the shikimate pathway. 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. YP_693194.1 s-adenosyl-l-methionine + dna adenine = s-adenosyl-l-homocysteine + dna 6-methylaminopurine. YP_693196.1 ammonium transporte YP_693198.1 mediate the uptake of a wide variety of molecules with the concomitant uptake of sodium ions (sodium symporters) YP_693201.1 Response regulator containing a CheY YP_693204.1 hydrolase. YP_693205.1 It removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction. It exhibits 3'-5'-exonuclease,3'-phosphomonoesterase, 3'-repair diesterase and ribonuclease h activities. Catalytic activity: degradation of double-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'- phosphates. YP_693207.1 Phosphohistidine phosphatase SixA YP_693208.1 sn-glycerol 3-phosphate + nad(p)(+) = glycerone phosphate + nad(p)h YP_693209.1 molecular chaperone. has atpase activity YP_693212.1 succinate thiokinase YP_693213.1 succinyl-CoA synthetase YP_693214.1 the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3) YP_693215.1 the branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-coa and co(2). it contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (e1), lipoamide acyltransferase (e2) and lipoamide dehydrogenase (e3) YP_693216.1 the 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-coa & co(2) (2-oxoglutarate + lipoamide = s-succinyldihydrolipoamide + co(2)) YP_693217.1 dehydrogenase YP_693218.1 succinate + acceptor = fumarate + reduced acceptor YP_693219.1 this is the hydrophobic component of the succinate dehydrogenase complex. it is suggested that it is required to anchor the catalytic components to the cytoplasmic membrane YP_693220.1 mono-heme cytochrome of the succinate dehydrogenase complex (by similarity) YP_693221.1 acetyl-coa + h(2)o + oxaloacetate = citrate + coa. YP_693222.1 unknown YP_693224.1 unknown YP_693227.1 COG: Outer membrane receptor proteins, mostly Fe transport YP_693229.1 atp + l-glutamate + trna(glu) = amp + diphosphate + l-glutamyl-trna(glu). YP_693233.1 unknown YP_693234.1 sedoheptulose 7-phosphate + d-glyceraldehyde 3-phosphate = d-erythrose 4-phosphate + d-fructose 6-phosphate. YP_693240.1 biosynthesis of fatty acids YP_693241.1 unknown YP_693242.1 hydrolyzes substrates with N-terminal glycine or alanine. YP_693248.1 unknown YP_693249.1 unknown YP_693250.1 protein l-methionine + oxidized thioredoxin = protein l-methionine s-oxide + reduced thioredoxin. YP_693251.1 protein l-methionine + oxidized thioredoxin = protein l-methionine s-oxide + reduced thioredoxin YP_693252.1 unknown YP_693255.1 transport and binding proteins YP_693257.1 hydrolase: (s)-2-haloacid + H(2)O = (r)-2-hydroxyacid + halide. YP_693259.1 educes FMN and also reduces riboflavin and FAD,although more slowly. Members of this family catalyzes the reaction NAD(P)H + FMN = NAD(P)(+) + FMNH(2). YP_693260.1 functions as an aerobic enzyme in the citric acid cycle YP_693264.1 catalyzes the reduction of arsenate to arsenite YP_693265.1 involved in tryptophan uptake and utilization. YP_693271.1 AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. YP_693282.1 unknown YP_693283.1 Formyltetrahydrofolate hydrolase YP_693285.1 FOG YP_693287.1 Formation of acetoacetyl-CoA from two molecules of acetyl-CoA. YP_693290.1 conversion of nadph, generated by peripheral catabolic pathways, to nadh, which can enter the respiratory chain for energy generation YP_693293.1 Phosphoribosylaminoimidazole (AIR) synthetase YP_693294.1 uses formyl tetrahydrofolate as a formyl group donor to produce 5'-phosphoribosyl-N-formylglycinamide YP_693297.1 hydrolyzes dUTP to dUMP and pyrophosphate YP_693298.1 ATPases involved in chromosome partitioning YP_693299.1 Uncharacterized conserved protein YP_693301.1 unknown YP_693302.1 Nucleotidyltransferase YP_693303.1 SOS-response transcriptional repressors (RecA-mediated autopeptidases) YP_693306.1 unknown YP_693307.1 . catalyzes the cleavage of the glycosidic bonds between n-acetylmuramic acid and n-acetylglucosamine residues in peptidoglycan. may play a role in recycling of muropeptides during cell elongation and/or cell division. YP_693308.1 nvolved in the fifth (last) step in the biosynthesis of spermidine from arginine and methionine. YP_693311.1 hydrolase. YP_693315.1 gdh catalyzes the reversible oxidative deamination of glutamate to 2-oxooglutarate and ammonia. YP_693319.1 is required not only for elongation of protein synthesis but also for the initiation of all mrna translation inititiator trna(fmet) aminoacylation (by similarity). YP_693320.1 cAMP YP_693322.1 These enzymes appear to be involved in the nucleic acid metabolism, signal transduction and possibly other functions. YP_693324.1 unknown YP_693329.1 may be part of a membrane complex involved in electron transport YP_693330.1 may be part of a membrane complex involved in electron transport YP_693331.1 may be part of a membrane complex involved in electron transport YP_693332.1 may be part of a membrane complex involved in nitrogen fixation YP_693333.1 may be part of a membrane complex involved in electron transport YP_693334.1 predicted NADH:ubiquinone oxidoreductase,subunit RnfE YP_693336.1 gltS is responsible for the sodium-dependent uptake of extracellular glutamate. YP_693337.1 Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA n-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. Catalytic activity: the c-o-p bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. YP_693341.1 forms anion selective channels (by similarity) YP_693342.1 unknown YP_693343.1 Guanosine polyphosphate pyrophosphohydrolases YP_693344.1 unknown YP_693345.1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB YP_693346.1 two cysteine synthase enzymes are found. both catalyze the same reaction. cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product. O(3)-acetyl-L-serine + H(2)S = L-cysteine + acetate. YP_693347.1 Signal transduction histidine kinase YP_693348.1 catalyses the condensation of 1-deoxy-d-xylulose-5-phosphate (DXP) and 1-amino-3-oxo-4-(phosphohydroxy)propan-2-one to form pyridoxine 5'-phosphate (PNP). YP_693349.1 Involved in DNA repair and recF pathway recombination YP_693350.1 binds both GDP and GTP, has an intrinsic GTPase activity and is essential for cell growth (by similarity). YP_693351.1 dsRNA-specific ribonuclease YP_693353.1 remove the signal peptides from secretory proteins YP_693354.1 Membrane GTPase LepA YP_693355.1 repression of the alginate biosynthesis by attenutation of AlgU acrivity YP_693356.1 Positive regulator for alginate biosynthesis YP_693357.1 Repression of alginate biosynthesis by attenuating the expression of algU YP_693358.1 Negative regulator of sigma E activity YP_693359.1 up-regulation of alginate biosynthesis YP_693361.1 catalyzes the oxidation of l-aspartate to iminoaspartate: l-aspartate + h(2)o + o(2) = oxaloacetate + nh(3) + h(2)o(2) YP_693362.1 unknown YP_693365.1 catalyze the reversible hydration of alpha,beta-unsaturated enoyl-CoA substrates to the corresponding beta-hydroxyacyl-CoA products YP_693366.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dump residues by DNA polymerase or due to deamination of cytosine. YP_693368.1 atp + l-lysine + trna(lys) = amp + diphosphate + l-lysyl-trna(lys). YP_693369.1 peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons uag and uaa (by similarity). YP_693371.1 Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events,although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available. YP_693373.1 acyl-CoA + acetyl-CoA= CoA + 3-oxoacyl-CoA YP_693382.1 dna-binding protein that preferentially recognizes a curved dna sequence YP_693384.1 exact function of these domains is unknown,however it isthought that they bind to some as yet unidentified small molecule (perhaps with an adenosyl moiety) and regulate the activity of attached enzymatic or other domains. YP_693391.1 unknown YP_693393.1 responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. YP_693394.1 responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. YP_693400.1 DnaK suppressor protein YP_693403.1 catalyzes the third step in the de novo biosynthesis of pyrimidine, the conversion of ureidosuccinic acid (N-carbamoyl-L-aspartate) into dihydroorotate YP_693404.1 hydrolase YP_693406.1 cysH catalyzes reduction of activated sulfate into sulfite. adenosine 3',5'-bisphosphate + sulfite + oxidized thioredoxin = 3'-phosphoadenylyl sulfate + reduced thioredoxin. YP_693409.1 Outer membrane receptor for ferrienterochelin and colicins YP_693410.1 Signal transduction histidine kinase YP_693411.1 Response regulators consisting of a CheY YP_693415.1 Superfamily II DNA and RNA helicases YP_693417.1 responsible for catalyzing the direct reduction of 4-Nitrobenzoate to 4-hydroxyaminobenzoate with the oxidation of 2 mol of NADH per mol of 4 NBen YP_693421.1 acyl-coa + etf = 2,3-dehydroacyl-coa + reduced etf. YP_693422.1 acyl-coa + etf = 2,3-dehydroacyl-coa + reduced etf. YP_693423.1 regulation of transcription, DNA-dependent YP_693424.1 reduces a range of alternative electron acceptors YP_693425.1 catalyzes the nadp-dependent reduction of 2,4-dienoyl- coa to yield trans-2- enoyl-coa YP_693428.1 member of the two-component regulatory system phoq/phop involved in the regulation of acid phosphatase. phoq may function as a membrane-associated protein kinase that phosphorylates phop in response to environmental signals. YP_693433.1 oxidoreductase YP_693436.1 unknown YP_693437.1 Ferredoxin (flavodoxin)-NADP(H) reductases (FNR) are ubiquitous flavoenzymes that deliver NADPH or low potential one-electron donors (ferredoxin, flavodoxin) to redox-based metabolisms YP_693444.1 biosynthesis YP_693448.1 unknown YP_693451.1 synthesis of acetyl-CoA from CO, CoA, and a methyl group YP_693456.1 unknown YP_693457.1 ABC transporter YP_693460.1 DNA uptake protein and related DNA YP_693461.1 catalyzes the last step in the de novo biosynthesis of pyrimidines, the decarboxylation of OMP into UMP YP_693462.1 unknown YP_693464.1 DNA binding activity. This protein is one of the two subunits of integration host factor, a specific dna-binding protein that functions in genetic recombination as well as in transcriptional and translational control (by similarity). YP_693465.1 ribosomal protein S1 binds mRNA; thus facilitating recognition of the initiation point. it is needed to translate mRNA with a short Shine-Dalgarno (sd) purine-rich sequence. YP_693466.1 phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP YP_693467.1 prephenate + NAD(+) = 4-hydroxyphenylpyruvate + CO(2) + NADH. phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. YP_693468.1 Histidinol-phosphate aminotransferase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme catalyzing a reversible transamination reaction between histidinol phosphate and 2-oxoglutarate to form imidazole acetol phosphate and glutamate. L-histidinol-phosphate + 2-oxoglutarate = 3- (imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. YP_693469.1 chorismate = prephenate and prephenate = phenylpyruvate + H(2)O + CO(2). YP_693470.1 O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate. YP_693471.1 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. Catalytic activity: ATP-dependent breakage,passage and rejoining of double-stranded DNA. Subunit made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an a2b2 tetramer. YP_693472.1 dechlorinate YP_693473.1 s-adenosyl-l-methionine + 3- demethylubiquinone-9 = s-adenosyl-l-homocysteine + ubiquinone-9. YP_693474.1 hydrolase. YP_693476.1 unknown YP_693477.1 unknown YP_693479.1 Predicted unusual protein kinase YP_693480.1 unknown YP_693481.1 unknown YP_693482.1 unknown YP_693488.1 cleaves multimeric trna precursor at the spacer region. YP_693489.1 required for binding carboxyl group of phosphoglycerates. YP_693490.1 unknown YP_693493.1 May play a role in DNA repair. It seems to be involved in an recBC-independent recombinational process of DNA repair. It may act with recF and recO. YP_693495.1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. Function: the tau chain serves as a scaffold to help in the dimerizaton of the core complex; the gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA. YP_693496.1 reversibly catalyses the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho- glycerate YP_693500.1 Predicted transcriptional regulators YP_693503.1 Catalyzes transglycosylation reactions YP_693505.1 insertes the DNA sequence YP_693507.1 is necessary for efficient DNA transposition YP_693511.1 take part in pathways involving acetyl-CoA YP_693514.1 Dihydroorotase YP_693515.1 unknown YP_693516.1 Carbon storage regulator (could also regulate swarming and quorum sensing) YP_693517.1 ATP + L-aspartate = ADP + 4-phospho-L-aspartate. YP_693518.1 atp + l-alanine + trna(ala) = amp + diphosphate + l-alanyl-trna(ala). YP_693519.1 Predicted permeases YP_693520.1 modulates recA activity (by similarity) YP_693521.1 can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with lexa causing its activation and leading to its autocatalytic cleavage. YP_693524.1 wax ester and triacylglycerol biosynthesis YP_693528.1 necessary for efficient DNA transposition YP_693529.1 this protein is involved in the repair of mismatches in DNA. it is possible that it carries out the mismatch recognition step. this protein has a weak ATPpase activity YP_693530.1 ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions YP_693531.1 hpt domain protein YP_693535.1 unknown YP_693536.1 synthesis of cardiolipin YP_693538.1 Exhibits a wide variety of catalytic activities including ATP-dependent exonuclease, ATP-stimulated endonuclease, ATP-dependent helicase and DNA-dependent ATPase activities. Catalytic activity: exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'-or 3'- to 5'-direction to yield 5'- phosphooligonucleotides. YP_693539.1 Required for efficient DNA repair; it catalyzes the unwinding of double-stranded DNA and the cleavage of single- stranded DNA and it stimulates local genetic recombination. All of these activities require concomitant hydrolysis of ATP. Catalytic activity: exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'-or 3'- to 5'-direction to yield 5'- phosphooligonucleotides. YP_693540.1 Exhibits several catalytic activities, including ATP-dependent exonuclease, ATP-stimulated endonuclease, ATP-dependent unwinding and DNA-dependent ATPase activities. Strand cleavage occurs 5' to 3' during the unwinding of duplex DNA at chi sequences, which locally stimulate recombination. Catalytic activity: exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'-or 3'- to 5'-direction to yield 5'-phosphooligonucleotides. YP_693545.1 Superfamily I DNA and RNA helicases and helicase subunits YP_693547.1 Uncharacterized conserved protein YP_693549.1 essential role in the activity of both the modification methylase and the restriction endonuclease YP_693550.1 plays an essential role in the activity of both the modification methylase and the restriction endonuclease. YP_693551.1 DNA recombination YP_693552.1 plays an essential role in the activity of both the modification methylase and the restriction endonuclease. YP_693554.1 Predicted transcriptional regulator YP_693555.1 Predicted transcriptional regulators YP_693556.1 Bacterial nucleoid DNA YP_693557.1 Phenylalanyl YP_693558.1 Phenylalanyl-tRNA synthetase YP_693559.1 This protein binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. it is not involved in the protein synthesizing functions of that subunit. YP_693560.1 Ribosomal protein L35 YP_693561.1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. IF-3 is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA. YP_693563.1 unknown YP_693565.1 decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. YP_693567.1 responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. YP_693568.1 responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. YP_693569.1 protein transporter activity YP_693570.1 GMP synthase YP_693571.1 IMP dehydrogenase YP_693572.1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions. Catalytic activity: exonucleolytic cleavage in either 5'-to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. YP_693573.1 response regulator YP_693576.1 Binding and hydrolyses GTP YP_693579.1 Histidyl-tRNA synthase YP_693580.1 converts 2c-methyl-d-erythritol 2,4-cyclodiphosphate (me-2,4cpp) into 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate (by similarity). YP_693581.1 unknown YP_693582.1 Tfp pilus assembly protein PilF YP_693584.1 reversible phosphoryl transfer YP_693586.1 ATP binding component of ABC transporter YP_693587.1 Permease component of ABC transporter YP_693588.1 catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine. L-cysteine sulfinic acid is the best substrate. functions as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. YP_693590.1 Predicted metal-sulfur cluster biosynthetic enzyme YP_693591.1 SufE protein probably involved in Fe YP_693592.1 catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. functions as a sulfur delivery protein for NAD,biotin and Fe-S cluster synthesis. transfers sulfur on cys-456 of thii in a transpersulfidation reaction. functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate. YP_693593.1 Predicted transcriptional regulator YP_693594.1 unknown YP_693597.1 unknown YP_693599.1 unknown YP_693612.1 presumably two functions, contains domain for hydrolysis of urea and two allophanate hydrolase domains YP_693614.1 Binds to the RNA polymerase (RNAp). Its ATPase activity is stimulated by binding to RNAp. YP_693615.1 Predicted esterase/carboxylesterase YP_693617.1 subunits i, ii and iii form the functional core of the enzyme complex YP_693618.1 exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper b into subunit i (by similarity) YP_693619.1 cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1- 3 form the functional core of the enzyme complex. co i is the catalytic subunit of the enzyme. electrons originating in cytochrome c are transferred via the copper a center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper b YP_693620.1 cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. subunits 1- 3 form the functional core of the enzyme complex. subunit 2 transfers the electrons from cytochrome c via its binuclear copper a center to the bimetallic center of the catalytic subunit 1 YP_693623.1 unknown YP_693625.1 required for cytochrome c biosynthesis. YP_693627.1 Predicted membrane protein YP_693629.1 protease YP_693632.1 DNA binding activity after temperature downshift YP_693634.1 oxidase YP_693635.1 unknown YP_693637.1 Catalyzes the acylation of 1-acyl-sn-glycerol-3-phosphate to phosphatidic acid YP_693638.1 oxidoreductase YP_693640.1 can carry out atp-dependent unwinding of double stranded rna. has a role in rna decay. involved in the rna degradosome, a multi-enzyme complex important in rna processing and messenger RNA degradation. YP_693642.1 COG: Opacity protein and related surface antigens YP_693644.1 Predicted ATPase related to phosphate starvation YP_693645.1 unknown YP_693646.1 unknown YP_693647.1 unknown YP_693652.1 unknown YP_693653.1 involved in biogenesis of respiratory systems. required for optimal cytochrome c oxidase activity YP_693654.1 unknown YP_693655.1 Phosphate starvation YP_693656.1 unknown YP_693660.1 Apolipoprotein N YP_693661.1 catalyses the hydrolysis of beta-lactams YP_693663.1 COG: Sulfate permease and related transporters (MFS superfamily) YP_693665.1 COG: Sulfate permease and related transporters (MFS superfamily) YP_693667.1 atp + leucine + trna(leu) = amp + diphosphate + leucyl-trna(leu). YP_693668.1 speculated to be involved in cell duplication YP_693669.1 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA. Catalytic activity: n deoxynucleoside triphosphate = n diphosphate + {dna}(n). YP_693671.1 catalyzes the nadph dependent reduction of l-gamma- glutamyl 5-phosphate into l-glutamate 5-semialdehyde and phosphate. the product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. l-glutamate 5-semialdehyde + phosphate + nadp(+) = l-gamma-glutamyl 5-phosphate + nadph. YP_693672.1 Nicotinic acid mononucleotide adenylyltransferase YP_693675.1 Peptidoglycan synthesis YP_693676.1 Bacterial cell division membrane protein YP_693677.1 catalyzes the cleavage of the glycosidic bonds between n-acetylmuramic acid and n- acetylglucosamine residues in peptidoglycan YP_693679.1 D-Ala-D-Ala carboxypeptidase is involved in the metabolism of cell components YP_693680.1 acts on the D-isomers of alanine, leucine,aspartate, glutamate, aminobutyrate, norvaline and asparagine. D-alanine + 2-oxoglutarate = pyruvate + D-glutamate. YP_693683.1 involved in the attachment of lipoyl groups to proteins,by creating an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoylated proteins (by similarity). YP_693684.1 synthesis of alpha-(+)-lipoic acid. it may be involved in the sulfur insertion chemistry in lipoate biosynthesis (by similarity). YP_693685.1 D-Ala-D-Ala carboxypeptidase is involved in the metabolism of cell components YP_693688.1 involved in the tonB-dependent energy-dependent transport of unidentified receptor-bound substrates YP_693689.1 involved in the tonb-dependent energy-dependent transport of various receptor-bound substrates YP_693690.1 iron ion transporter activity YP_693691.1 might be involved in metal ion uptake YP_693694.1 reutilizes the intact tripeptide l-alanyl-gamma-d- glutamyl-meso-diaminopimelate by linking it to udp-n-acetylmuramic acid YP_693695.1 catalyzes the synthesis of macrocyclic lactones in anhydrous organic solvents YP_693696.1 seems to be acting in the folding of the extracellular lipase during its passage through the periplasm (by similarity). YP_693698.1 hydrolyzes formamide with the production of ammonia which can be used as a source of nitrogen for growth. also acts, more slowly, on acetamide, propanamide and butanamide YP_693699.1 chaperone activity YP_693700.1 hydrolyse mid-chain aliphatic amides and which are coupled with nitrile hydratases to be involved in microbial nitrile metabolism ( YP_693702.1 component of the high-affinity branched-chain amino acid transport system. YP_693707.1 Response regulators consisting of a CheY YP_693709.1 Synthesis of fructose 1,6-bisphosphate from fructose 6-phosphate and MgATP YP_693710.1 transport of uracil in the cell YP_693711.1 Uracil phosphoribosyltransferase YP_693713.1 sulfurtransferase involved in cyanide detoxification. YP_693714.1 diphosphate + h(2)o = 2 phosphate YP_693715.1 transcriptional regulation YP_693717.1 unknown YP_693718.1 may be an environmental sensor responsive to several stimuli, including internal ph, proton motive force, temperature, and possibly other unknown factors. YP_693719.1 unknown YP_693721.1 regulatory system: plays a role in the adaptation of the organism to the host environment YP_693722.1 presumably involved in the thiamine synthesis YP_693723.1 unknown YP_693724.1 unknown YP_693725.1 unknown YP_693726.1 required for disulfide bond formation in some periplasmic proteins. could also act as a disulfide oxidoreductase in cytochromes c biogenesis. the cysteines of apocytochromes c must be in the reduced state for covalent linkage between the two moieties to occur (by similarity). YP_693727.1 required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. this transfer involves a cascade of disulfide bond formation and reduction steps (by similarity) .Catalytic activity: protein dithiol + nad(p)+ = protein disulfide + nad(p)h YP_693728.1 catalyzes a trans-dehydration via an enolate intermediate. 3-dehydroquinate = 3-dehydroshikimate + H(2)O. YP_693729.1 Biotin carboxyl carrier protein YP_693730.1 this protein is a component of the acetyl coenzyme a carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. atp + biotin-carboxyl-carrier protein + co(2) = adp + phosphate + carboxybiotin-carboxyl-carrier protein. YP_693731.1 Methylates ribosomal protein L11 YP_693732.1 unknown YP_693733.1 molecular_function unknown YP_693734.1 Factor for inversion stimulation Fis,transcriptional activator YP_693735.1 bifunctional enzyme, catalysing the last two steps in de novo purine biosynthesis YP_693736.1 Phosphoribosylamine YP_693737.1 cAMP YP_693738.1 sensory transduction YP_693739.1 ATPases YP_693740.1 unknown YP_693741.1 decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine. S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO(2). YP_693743.1 cAMP YP_693744.1 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO(2) + H(2)O. YP_693745.1 anthranilate + phosphoribosylpyrophosphate = N-5'-phosphoribosyl-anthranilate + diphosphate. YP_693746.1 chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. component 2 provides glutamine amidotransferase activity. YP_693747.1 chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. YP_693751.1 Response regulator consisting of a CheY YP_693752.1 sensor histide kinase YP_693753.1 seems to be involved in the biogenesis of cytochrome c oxidase YP_693754.1 cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain YP_693755.1 cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain. YP_693756.1 cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain YP_693757.1 cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain of e.coli that predominates when cells are grown at high aeration (by similarity) YP_693758.1 metabolite transport YP_693759.1 reduces a range of alternative electron acceptors YP_693760.1 Predicted transcriptional regulators YP_693762.1 converts D-ribulose 5-phosphate into D-xylulose 5-phosphate in Calvin's reductive pentose phosphate cycle YP_693766.1 assist in the folding of extracytoplasmic proteins. YP_693767.1 catalyzes the condensation of 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose, to form either pyridoxine (vitamin B6) or pyridoxine 5'-phosphate (PNP). YP_693768.1 responsible for the dimethylation of adenosines inribosomal RNAs. YP_693769.1 unknown YP_693770.1 Diadenosine tetraphosphatase and related serine YP_693771.1 unknown YP_693773.1 oxydation of alcohols YP_693774.1 unknown YP_693775.1 unknown YP_693776.1 catalyzes the attachment of pyrophosphate to 6-hydroxymethyl-7,8-dihydropterin to form 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate. YP_693777.1 catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. YP_693779.1 proteolysis and peptidolysis; Main role: Protein fate; Subrole: Degradation of proteins, peptides,and glycopeptides. YP_693780.1 Ribosomal protein S21 YP_693782.1 DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis. YP_693783.1 The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. YP_693784.1 shufflon-specific dna recombinase YP_693786.1 unknown YP_693787.1 unknown YP_693788.1 unknown YP_693789.1 unknown YP_693791.1 unknown YP_693794.1 ATPases involved in chromosome partitioning YP_693796.1 unknown YP_693797.1 unknown YP_693798.1 cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. YP_693800.1 unknown YP_693801.1 necessary for efficient DNA transposition YP_693802.1 necessary for efficient DNA transposition YP_693805.1 unknown YP_693806.1 Superfamily II DNA and RNA helicases YP_693808.1 involved in the reduction of ferric iron in cytoplasmic ferrioxamine b YP_693809.1 catalyzes the hydroxylation of l-ornithine (l-orn) YP_693810.1 aerobactin biosynthesis. YP_693811.1 ferrioxamine binding and uptake, in association with the tonb protein (by similarity). may play a role in intestinal colonization. YP_693812.1 induces peptide synthesis. YP_693813.1 induces peptide synthesis. YP_693816.1 trascriptional regulator YP_693817.1 It is thought to normally generate double strand breaks in DNA, except in the presence of high salt concentrations and RNA, when it generates single strand breaks in DNA YP_693818.1 catalyzes the first step in oxidation of fatty acids YP_693819.1 l-glutamate + h(2)o + nadp(+) = 2-oxoglutarate + nh(3) + nadph. YP_693820.1 L-glutamate + H(2)O + NAD(P)(+) = 2-oxoglutarate + NH(3) + NAD(P)H. YP_693822.1 catalyzes the first step in oxidation of fatty acids YP_693823.1 unknown YP_693824.1 outer membrane bound acyl hydrolase with a broad substrate specificity YP_693825.1 unknown YP_693826.1 transcriptional regulator YP_693827.1 oxidoreductase YP_693828.1 hydrolysis of water- soluble or insoluble esters, including triglycerides YP_693829.1 oxidoreductase YP_693835.1 unknown YP_693836.1 transcriptional regulator YP_693838.1 FOG: GGDEF domain YP_693839.1 Flavodoxin reductases (ferredoxin YP_693840.1 molecular function unknown YP_693841.1 unknown YP_693842.1 unknown YP_693843.1 transcriptional regulator YP_693844.1 this enzyme catalyzes the 6-electron reduction of sulfite to sulfide. this is one of several activities required for the biosynthesis of l-cysteine from sulfate. the flavo- protein component catalyzes the electron flow from nadph -> fad -> fmn to the hemoprotein component. YP_693845.1 this enzyme catalyzes the 6-electron reduction of sulfite to sulfide. this is one of several activities required for the biosynthesis of l-cysteine from sulfate. Catalytic activity: h(2)s + 3 nadp(+) + 3 h(2)o = sulfite + 3 nadph. YP_693846.1 this enzyme catalyzes the 6-electron reduction of sulfite to sulfide. this is one of several activities required for the biosynthesis of l-cysteine from sulfate. Catalytic activity: h(2)s + 3 nadp(+) + 3 h(2)o = sulfite + 3 nadph. YP_693849.1 unknown YP_693850.1 Members of this family catalyse the denitrification of a number of nitroalkanes using either FAD or FMN as a cofactor YP_693852.1 HD YP_693853.1 atp + l-threonine + trna(thr) = amp + diphosphate + l-threonyl-trna(thr). YP_693854.1 1-(5-phosphoribosyl)-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylidene amino]imidazole-4-carboxamide. YP_693855.1 atp + l-cysteine + trna(cys) = amp + diphosphate + l-cysteinyl-trna(cys). YP_693856.1 unknown YP_693858.1 Outer membrane receptor proteins, mostly Fe transport YP_693861.1 Universal stress protein UspA and related nucleotide YP_693866.1 catalyze uptake of dicarboxylates in a H(+)- or Na(+)-dicarboxylate symport YP_693867.1 catalyze uptake of dicarboxylates in a H(+)- or Na(+)-dicarboxylate symport YP_693868.1 Exchange or efflux of C4-dicarboxylates YP_693869.1 Transcriptional regulators YP_693870.1 Ectoine biosynthesis YP_693871.1 ectB catalyzes the first step of ectoine synthesis. L-2,4-diaminobutanoate + pyruvate = L-aspartate 4-semialdehyde + L-alanine. YP_693872.1 Cyclic condensation of gamma-n-acetyl-alpha,gamma- diaminobutyric acid (adaba) to ectoine. Pathway biosynthesis of ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid); last step. YP_693874.1 the n-terminal region is similar to that of other regulatory components of sensory transduction systems. YP_693875.1 response regulator YP_693876.1 invloved in the dna synthesis YP_693877.1 Predicted signal transduction protein YP_693878.1 COG: Na+/proline symporter YP_693882.1 molecular_function unknown YP_693884.1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions. Catalytic activity: exonucleolytic cleavage in either 5'-to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates. YP_693885.1 catalyze a 1'4-condensation between 5 carbon isoprene units. YP_693886.1 catalyzes the acyloin condensation reaction between c atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-d-xylulose-5-phosphate (dxp). pyruvate + d-glyceraldehyde 3-phosphate = 1- deoxy-d-xylulose 5-phosphate + co(2). YP_693887.1 FOG YP_693888.1 involved in the biosynthesis of phosphatidylglycerol YP_693889.1 atp + thiamine phosphate = adp + thiamine diphosphate YP_693890.1 involved in the transcription termination process (by similarity). YP_693891.1 2 6,7-dimethyl-8-(1-d-ribityl)lumazine = riboflavin + 4-(1-d-ribitylamino)-5-amino-2,6-dihydroxypyrimidine YP_693892.1 riboflavin biosynthesis. YP_693893.1 riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-d)- ribityl-amino-2,4(1h,3h)-pyrimidinedione and l-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. the alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-d)-ribityl-amino-2,4(1h,3h)- pyrimidinedione. YP_693894.1 converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate YP_693895.1 Predicted transcriptional regulator YP_693896.1 interconversion of serine and glycine. 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine. YP_693897.1 ABC transporter YP_693899.1 the sigma factor is an initiation factor that promotes attachment of the rna polymerase to specific initiation sites and then is released (by similarity). YP_693902.1 COG: Methylase involved in ubiquinone/menaquinone biosynthesis YP_693903.1 resistance to hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. mera protein is responsible for volatilizing mercury as hg(0) YP_693905.1 May play a role in the repair of endogenous alkylation damage YP_693906.1 provides the d-alanine required for cell wall biosynthesis (by similarity). YP_693907.1 Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with dnaC protein,primase, and other prepriming proteins. subunit homohexamer. YP_693908.1 binds to the 23S rRNA. YP_693909.1 This protein has been implicated in aminoacyl-transfer RNA binding. It appears to be situated at the decoding site of messenger RNA. YP_693910.1 pria recognizes a specific hairpin sequence on phix ssdna. this structure is then recognized and bound by proteins prib and pric. formation of the primosome proceeds with the subsequent actions of dnab, dnac, dnat and primase. YP_693911.1 Binds together with S18 to 16S ribosomal RNA. YP_693912.1 rRNA methyltransferase YP_693913.1 Exoribonuclease R YP_693914.1 unknown YP_693917.1 catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP YP_693919.1 unknown YP_693920.1 protease YP_693921.1 protease YP_693922.1 GTP-binding YP_693923.1 rna-binding protein that stimulates the elongation of poly(a) tails (by similarity) YP_693924.1 catalyzes the first step in the biosynthesis of 2- methylthio-n6-(delta(2)-isopentenyl)-adenosine (ms[2]i[6]a]) adjacent to the anticodon of several trna species YP_693926.1 Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling (by similarity). Catalytic activity: hydrolyzes the link between n-acetylmuramoyl residues and l-amino acid residues in certain bacterial cell-wall glycopeptides. YP_693928.1 unknown YP_693929.1 electron transport protein YP_693930.1 Oligoribonuclease (3 YP_693932.1 thiosulfate + cyanide = sulfite + thiocyanate. YP_693933.1 synthesis of phosphatidylethanolamine YP_693934.1 COG: Poly(3-hydroxyalkanoate) synthetase YP_693935.1 transfer heptose to the lipopolysaccharide core YP_693936.1 atp + 7,8-diaminononanoate + co(2) = adp + phosphate + dethiobiotin YP_693938.1 seems to be implicated in the early steps of biotin biosynthesis. YP_693939.1 catalytic activity 6-carboxyhexanoyl-coa + l-alanine = 8-amino-7- oxononanoate + coa + co(2) YP_693940.1 dethiobiotin + sulfur = biotin YP_693943.1 acyl-coa + etf = 2,3-dehydroacyl-coa + reduced etf. YP_693945.1 involved in tetrahydrobiopterin biosynthesis. YP_693946.1 unknown YP_693947.1 catalyzes the sequential decarboxylation of the four acetyl side chains of uroporphyrinogen to yield coproporphyrinogen (uroporphyrinogen-iii = coproporphyrinogen + 4 co(2)) YP_693948.1 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH. YP_693949.1 gltB is a complex iron-sulfur flavoprotein that catalyzes the reductive transfer of L-glutamine amide group to the C(2) carbon of 2-oxoglutarate (2-OG) using either reduced pyridine nucleotides (NADH or NADPH) or reduced ferredoxin (Fd) as the physiological electron transfer system. YP_693951.1 3-deoxy-arabino-heptulosonate 7-phosphate = 3-dehydroquinate + phosphate. YP_693952.1 ATP + shikimate = ADP + shikimate 3-phosphate. YP_693958.1 cell wall formation. synthesis of cross-linked peptidoglycan from the lipid intermediates. the enzyme has a penicillin-insensitive transglycosylase n-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase c-terminal domain (cross-linking of the peptide subunits) (by similarity). YP_693959.1 (s)-malate + nadp(+) = pyruvate + co(2) + nadph YP_693960.1 Ribosomal protein L31 YP_693961.1 Recognizes a specific hairpin sequence on phix ssDNA; this structure is then recognized and bound by proteins priB and priC. Formation of the primosome proceeds with the subsequent actions of dnaB, dnaC, dnaT and primase. priA then functions as a helicase within the primosome. YP_693962.1 atp + l-arginine + trna(arg) = amp + diphosphate + l-arginyl-trna(arg). YP_693963.1 unknown YP_693964.1 Protease subunit of a proteasome-like degradation complex. Subunit: a double ring-shaped homohexamer of hslV is capped on each side by a ring-shaped hslU homohexamer. YP_693965.1 Chaperone subunit of a proteasome-like degradation complex. Subunit: a double ring-shaped homohexamer of hslV is capped on each side by a ring-shaped hslU homohexamer. YP_693966.1 converts ddmqh2 into dmqh2 and dmkh2 into mkh2. YP_693967.1 unknown YP_693968.1 required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (by similarity) YP_693969.1 1-(5-phosphoribosyl)-ATP + H(2)O = 1-(5-phosphoribosyl)-AMP + diphosphate YP_693970.1 required to correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif s/t-r-r-x-f-l-k. this sec-independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity). YP_693971.1 required to correct localization of precursor proteins bearing signal peptides with the twin arginine conserved motif s/t-r-r-x-f-l-k. this sec-independent pathway is termed tat for twin-arginine translocation system. this system mainly transports proteins with bound cofactors that require folding prior to export (by similarity). YP_693972.1 has a remarkable ability to transport folded proteins even enzyme complexes across the cytoplasmic membrane. YP_693973.1 Hydrolases of the alpha YP_693976.1 ydrolyzes d-tyrosyl-trna(tyr) into d-tyrosine and free trna(tyr). could be a defense mechanism against a harmful effect of d-tyrosine (by similarity) YP_693977.1 specifically catalyzes the removal of n-terminal proline residues from peptides (by similarity). YP_693978.1 unkown YP_693979.1 Response regulator containing CheY YP_693980.1 Signal transduction histidine kinase YP_693982.1 ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine. YP_693984.1 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC: 2.1.1.61) catalyses the addition of 5-methylaminomethyl-2-thiouridylate to tRNAs using S-adenosyl-L-methionine as a substrate and releasing S-adenosyl-L-homocysteine. The enzyme is cytoplasmic and is involved in tRNA processing. YP_693989.1 Predicted membrane GTPase involved in stress response YP_693991.1 Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. YP_693992.1 This is one of the proteins required for the normal export of envelope proteins out of the cell cytoplasm; it may be involved in the initiation of the exporting process, by binding to the nascent polypeptide via a signal sequence, maintaining a stable and pre-translocation conformation. Subunit. part of the prokaryotic protein translocation apparatus which comprise secA, secB, secD, secE, secF, secG and secY YP_693993.1 It functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. YP_693995.1 unknown YP_693996.1 Periplasmic protease YP_693998.1 catalyzes the conversion of prfar and glutamine to igp, aicar and glutamate. the hisf subunit catalyzes the cyclization activity that produces igp and aicar from prfar using the ammonia provided by the hish subunit. 5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5- aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O. YP_693999.1 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide = 5- [(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-( 5- phosphoribosyl)imidazole-4-carboxamide. YP_694000.1 imidazole glycerol phosphate synthase catalyzes the conversion of prfar and glutamine to igp, aicar and glutamate. the hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of igp and aicar. 5-[(5-phospho-1-deoxyribulos-1- ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4- carboxamide + L-glutamine = imidazole-glycerol phosphate + 5- aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O. YP_694001.1 D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O. YP_694002.1 unknown YP_694003.1 member of the two-component regulatory system yycg/yycf involved in the regulation of the ftsaz operon YP_694005.1 Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past go lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8- oxoguanine. YP_694007.1 nvolved in the transposition of the insertion sequences. YP_694009.1 unknown YP_694010.1 involved in the biosynthesis of the lipopolysaccharide (LPS) core component YP_694011.1 possibly involved in lpipolysaccharides (LPS) biosynthesis (by similarity to P. putida) YP_694012.1 transfers myristate or laurate during lipopolysaccharide core biosynthesis YP_694013.1 possibly involved in the biosynthesis of lipopolysaccharides (LPS), by similarity to P. putida YP_694014.1 possibly involved in biosyntheis of lipopolysaccharides (LPS) YP_694015.1 possibly involved in the biosynthesis of the lipopolysaccharides (LPS) YP_694016.1 addition of phosphate to O-4 of the first heptose residue of the lipopolysaccharide (LPS) inner core region. YP_694017.1 Involved in the biosynthesis of the lipopolysaccharides (LPS) outer core YP_694018.1 involved in the biosynthesis of the lipopolysaccharides (LPS) inner core component by transferring the first (innermost) heptose to KDO YP_694019.1 involved in the biosynthesis of thel lipopolysaccharides (LPS), probably by phosphorylation of a heptose of the outer LPS core YP_694020.1 involved in the biosynthesis of the lipopolysaccharides (LPS) by transferring the second heptose to the LPS outer core YP_694021.1 acts on leucine, isoleucine and valine. L-leucine + 2-oxoglutarate = 4-methyl-2- oxopentanoate + L-glutamate. YP_694022.1 Glutamine synthetase adenylyltransferase YP_694023.1 involved in a general secretion pathway (gsp) for the export of proteins. required for the translocation of pectate lyases and cellulases across the outer membrane YP_694024.1 unknown YP_694025.1 inorganic phosphate transport YP_694026.2 acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. YP_694028.1 unknown YP_694032.1 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H(2)O. YP_694033.1 2-hydroxychromene-2-carboxylate isomerase (hcca isomerase). YP_694034.1 unknown YP_694039.1 Uncharacterized enzyme of heme biosynthesis, presumably involved in a late step of protoheme ix synthesis YP_694040.1 Uncharacterized enzyme of heme biosynthesis YP_694041.1 catalyses the reaction: Hydroxymethylbilane <=> uroporphyrinogen-III + H(2)O, by sequence similarity YP_694042.1 4 porphobilinogen + h(2)o = hydroxymethylbilane + 4 nh(3) YP_694043.1 Response regulator of the LytR/AlgR family YP_694044.1 essential for alginate synthesis and algD transcriptional activation YP_694045.1 N-(L-arginino)succinate = fumarate + L-arginine. YP_694046.1 rnk can functionally replace alginate regulatory gene algr2. YP_694048.1 meso-2,6-diaminoheptanedioate = L-lysine + CO(2). YP_694049.1 involved in ph homeostasis and sodium extrusion YP_694050.1 Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine YP_694051.1 unknown YP_694052.1 LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. YP_694053.1 Uncharacterized protein conserved in bacteria YP_694054.1 site specific integrase/recombinase YP_694055.1 Predicted hydrolase (HAD superfamily) YP_694057.1 unknown YP_694061.1 unknown YP_694062.1 Predicted redox protein YP_694063.1 catalyses the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate YP_694064.1 Thymidylate synthase YP_694065.1 Transfers the n-acyl diglyceride group on what will become the n-terminal cysteine of membrane lipoproteins. YP_694068.1 Signal transduction protein containing GAF and PtsI domains YP_694069.1 hydrolyzes diadenosine polyphosphate (by similarity). YP_694072.1 unknown YP_694073.1 Involved in copper efflux. Catalytic activity: ATP + h(2)o + cu(2+)(in) = ADP + phosphate + cu(2+)(out). YP_694074.1 unknown YP_694079.1 mediates copper resistance by sequestration of copper in the periplasm along with the copper-binding protein copc. may have oxidase activity YP_694080.1 Required for the copper-inducible expression of copper resistance. YP_694081.1 reversible hydration of carbon dioxide. YP_694082.1 function together with moac, is involved in the conversion of a guanosine derivative (gxp) into molybdopterin precursor z (by similarity) YP_694083.1 accelerate the folding of proteins (by similarity). YP_694084.1 Catalysis of the reaction: L-glutamate = D-glutamate. YP_694085.1 catalyzes amidations at positions b, d, e, and g on adenosylcobyrinic a,c-diamide YP_694086.1 atp + cob(i)alamin + h(2)o = phosphate + diphosphate + adenosylcobalamin. YP_694091.1 Outer membrane cobalamin receptor protein YP_694092.1 unknown YP_694094.1 2 ferrocytochrome c + h(2)o(2) = 2 ferricytochrome c + 2 h(2)o. YP_694096.1 catalyzes the late steps in adenosylcobalamin biosynthesis, which define the nucleotide loop assembly pathway. YP_694097.1 involved in the conversion of cobyric acid to cobinamide. addition of aminopropanol on the f carboxylic group YP_694098.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (namn) and 5,6-dimethylbenzimidazole (dmb) (beta-nicotinate d-ribonucleotide + dimethylbenzimidazole = nicotinate + n(1)-(5-phospho-alpha-d- ribosyl)-5,6-dimethylbenzimidazole) YP_694100.1 atp-dependent phosphorylation of adenosylcobinamide and adds gmp to adenosylcobinamide phosphate. YP_694101.1 genes involved in alkylphosphonate uptake YP_694102.1 involved in the biosynthesis of a demolybdo-cofactor (molybdopterin), necessary for molybdo-enzymes. seems to be involved in a step of activation of molybdenum in the form of thiomolybdenum (by similarity). YP_694103.1 involved in the biosynthesis of molybdopterin precursor z from guanosine YP_694104.1 oxidative degradation of various compounds YP_694105.1 unclear YP_694106.1 hydrolyzes a broad-spectrum of beta-lactams YP_694108.1 unknown YP_694109.1 unknown YP_694110.1 unknown YP_694111.1 converts hydroxypyruvate to glycerate ((r)-glycerate + nad(+) = hydroxypyruvate + nadh) YP_694112.1 unknown YP_694113.1 cofactor and FAD prosthetic group, these microsomal proteins catalyse the oxygenation of nucleophilic nitrogen, sulphur, phosphorous and selenium atoms in a range of structurally diverse compounds. YP_694114.1 Catalysis of oxidation-reduction (redox) reactions YP_694115.1 unknown YP_694116.1 unknown YP_694117.1 this protein seems to be a 2fe-2s ferredoxin.this dioxygenase system consists of four proteins: the two subunits of the hydroxylase component (bpha1 and bpha2), a ferredoxin (bpha3) and a ferredoxin reductase (bpha4). YP_694118.1 L-arginine = agmatine + CO(2). YP_694119.1 S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine. YP_694121.1 gentisate catabolism YP_694122.1 control the expression of genes associated with the biosynthesis of cysteine in bacteria. YP_694123.1 catalyzes the isomerization of 2 and 3-phosphoglycerates, and are essential for glucose metabolism YP_694124.1 Most dehydrogenases possess at least 2 domains , the first binding the coenzyme, often NAD, and the second binding the substrate. This latter domain determines the substrate specificity and contains amino acids involved in catalysis. YP_694125.1 unclear YP_694128.1 . The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. YP_694129.1 unknown YP_694132.1 unknown YP_694133.1 not known; may be involved in recombination (by similarity). YP_694134.1 catalyzes the nadph-dependent reduction of 3-deoxyglucosone (3-dg) YP_694135.1 1-haloalkane + h(2)o = a primary alcohol + halide. YP_694136.1 unknown YP_694137.1 unknown YP_694138.1 transcriptional regulator YP_694139.1 conversion of an alcohol to acetaldehyde YP_694140.1 unclear YP_694141.1 cytochrome d terminal oxidase complex is the component of the aerobic respiratory chain YP_694142.1 ubiquinol-8 + o(2) = ubiquinone-8 + h(2)o YP_694143.1 unknown YP_694144.1 unknown YP_694145.1 growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs YP_694147.1 LysR substrate binding domain, by sequence similarity YP_694148.1 Glo 1 catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by Glo 2 to lactic acid. YP_694149.1 unknown YP_694150.1 Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the ahpC protein. YP_694151.1 Directly reduces organic hydroperoxides in its reduced dithiol form. YP_694152.1 unknown YP_694154.1 peptidoglycan synthesis; final stages. YP_694155.1 unknown YP_694157.1 catalyzes the condensation of the acetyl group of acetyl-coa with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Acetyl-CoA + 3-methyl-2-oxobutanoate + h(2)o = 2-hydroxy-2-isopropylsuccinate + CoA. YP_694158.1 transcriptional regulator. YP_694160.1 catalyze the reversible hydration of alpha, beta-unsaturated enoyl-CoA substrates to the corresponding beta-hydroxyacyl-CoA products YP_694161.1 unknown YP_694162.1 phosphoserine + H(2)O = serine + phosphate. YP_694163.1 unknown YP_694164.1 unknown YP_694166.1 involved in peptide bond synthesis. stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70s ribosomes in vitro. probably functions indirectly by altering the affinity of the ribosome for aminoacyl-trna, thus increasing their reactivity as acceptors for peptidyl transferase. YP_694167.1 atp + l-lysine + trna(lys) = amp + diphosphate + l-lysyl-trna(lys). YP_694168.1 unknown YP_694169.1 catalyze the formation of hydroxil groups in organic compounds YP_694170.1 transcriptional regulator YP_694171.1 unknown YP_694172.1 acyl-CoA + acetyl-CoA= CoA + 3-oxoacyl-CoA YP_694173.1 catalyzes the first step in oxidation of fatty acids YP_694174.1 hydrolysis of water- soluble or insoluble esters, including triglycerides YP_694175.1 unknown YP_694176.1 unknown YP_694177.1 necessary for efficient rna polymerase transcription elongation past template-encoded arresting sites. the arresting sites in dna have the property of trapping a certain fraction of elongating rna polymerases that pass through, resulting in locked ternary complexes. cleavage of the nascent transcript by cleavage factors such as grea or greb allows the resumption of elongation from the new 3'terminus. greb releases sequences of up to 9 nucleotides in length (by similarity). YP_694178.1 catalyze the incorporation of oxygen of O2 into organic compounds YP_694179.1 2 5-aminolevulinate = porphobilinogen + 2 h(2)o YP_694180.1 formation of polyphosphate from ATP YP_694181.1 Exopolyphosphatase YP_694182.1 participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions YP_694183.1 facilitates transcription termination by a mechanism that involves rho binding to the nascent rna, activation of rho's rna-dependent atpase activity, and release of the mrna from the dna template (by similarity). YP_694186.1 oxidoreductase YP_694188.1 involved in the transposition of the insertion sequence. YP_694190.1 Increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these ions from cells, however others are implicated in ion uptake. YP_694191.1 Increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these ions from cells, however others are implicated in ion uptake. YP_694192.1 Increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these ions from cells, however others are implicated in ion uptake. YP_694193.1 Increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these ions from cells, however others are implicated in ion uptake. YP_694194.1 unknown YP_694195.1 involved in the transposition of the insertion sequence. YP_694197.1 Increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these ions from cells, however others are implicated in ion uptake. YP_694198.1 unknown YP_694199.1 unknown YP_694201.1 Specific receptor for the siderophore ferric enterobactin. YP_694202.1 Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + ammonia. YP_694203.1 an alcohol + nad(+) = an aldehyde or ketone + nadh. YP_694206.1 receptor for the siderophore, ferripyoverdine. YP_694207.1 eceptor for the siderophore, ferripyoverdine. YP_694211.1 unknown YP_694213.1 Topoisomerase IV is essential for chromosome segregation. It has relaxation of supercoiled DNA activity. Performs the decatenation events required during the replication of a circular DNA molecule. Subunit composed of two subunits: parC and parE. YP_694214.1 Topoisomerase iv is essential for chromosome segregation. It has relaxation of supercoiled DNA activity. Performs the decatenation events required during the replication of a circular DNA molecule. Subunit composed of two subunits: parc and pare. YP_694217.1 unknown YP_694218.1 adp-ribose + h(2)o = amp + d-ribose 5-phosphate. YP_694219.1 required for the synthesis of the hydromethylpyrimidine (hmp) moiety of thiamine (4-amino-2-methyl-5- hydroxymethylpyrimidine) YP_694220.1 required for proper expression of outer membrane protein genes such as ompf, nmpc, protein 2,hemolysin, colicin v, or colicin e1. may be specialized for signal sequence independent, extracellular secretion in gram-negative bacteria. YP_694221.1 Involved in the biosynthesis of the essential lipopolysaccharide (LPS) component lipd A by transferring of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVa). Transfers a single molecule of KDO to lipid IVa. YP_694222.1 unknown YP_694223.1 unknown YP_694224.1 unknown YP_694226.1 hydrolysis of amides YP_694227.1 unknown YP_694228.1 transcriptional regulator YP_694229.1 trasnporter YP_694232.1 Probable involved in the transport of branched chain amino acids YP_694233.1 component of the amino acid transport system. YP_694234.1 unknown YP_694235.1 sodium dependent transport YP_694237.1 Signal transduction histidine kinase YP_694238.1 trasncription regulator YP_694239.1 Response regulator containing a CheY YP_694242.1 could be a drug/metal efflux pump YP_694243.1 could be a drug efflux pump YP_694244.1 transcriptional regulator. YP_694245.1 unknown YP_694246.1 unknown YP_694247.1 could function in transcriptional regulation of sigma-54 dependent operons in conjunction with the npr (ptso) and iia-ntr (ptsn) proteins thereby providing a link between carbon and nitrogen assimilatory pathways. phosphoenolpyruvate + protein l-histidine = pyruvate + protein n(pi)-phospho-l-histidine. YP_694249.1 COG: Ammonia permease YP_694250.1 P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents nr-ii catalyzed conversion of nr-i to nr-i-phosphate, the transcriptional activator of glnA. when P-II is uridylylated to P-II-UMP, these events are reversed. when the ratio of gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylylation of glutamine synthetase by glnE, so activating the enzyme. YP_694252.1 unknown YP_694253.1 acyl-coa + etf = 2,3-dehydroacyl-coa + reduced etf. YP_694254.1 NAD- or NADP-dependent oxidoreductases. YP_694255.1 responsible for removing an oxidatively damaged form of guanine (8-hydroxy- guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool (by similarity) YP_694256.1 transcriptional regulator YP_694257.1 Formation of pseudouridine from uracil-516 in 16S ribosomal RNA (by similarity). Catalytic activity: uracil + d-ribose 5-phosphate = pseudouridine 5'-phosphate + h(2)o. YP_694258.1 Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. YP_694259.1 this is a monoheme c-type cytochrome. It is unreactive with cytochrome c reductase or oxidase but seems to function as an intermediate in nitrate respiration. YP_694260.1 Electron transport YP_694261.1 Predicted transmembrane sensor domain YP_694262.1 unknown YP_694263.1 Response regulators consisting of a CheY YP_694264.1 Membrane transporters of cations and cationic drugs YP_694265.1 transcriptional regulator YP_694266.1 catalyze the insertionof a double bond at the delta position of fatty acids YP_694268.1 unknown YP_694269.1 unknown YP_694270.1 unknown YP_694271.1 unknown YP_694272.1 unknown YP_694275.1 transforms O-acetylhomoserine into homocysteine. O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. YP_694276.1 catalyze the reversible hydration of alpha, beta-unsaturated enoyl-CoA substrates to the corresponding beta-hydroxyacyl-CoA products YP_694278.1 unknown YP_694281.1 Uncharacterized protein involved in response to NO YP_694286.1 Functional homolog of srp receptor. Probably involved in the reception and insertion of a subset of proteins at the cytoplasmic membrane. YP_694287.1 is coded in an operon essential for cell division. YP_694288.1 is coded in an operon essential for cell division. YP_694289.1 The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released. This sigma factor is responsible for the expression of heat shock promoters. YP_694291.1 Sulfur transfer protein involved in thiamine biosynthesis YP_694292.1 Uncharacterized enzyme of thiazole biosynthesis YP_694293.1 probably involved in the transfer of one-carbon groups YP_694294.1 unknown YP_694295.1 unknown YP_694296.1 acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine. YP_694297.1 osylmethyonine SAM YP_694298.1 HAM1 protein protects the cell from 6-N-hydroxylaminopurine (HAP), either on the level of deoxynucleoside triphosphate or the DNA level by a yet unidentified set of reactions YP_694299.1 Uncharacterized protein conserved in bacteria YP_694302.1 unknown YP_694303.1 This enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. Also involved in the go system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine = 7-oxog) from DNA. Can also nick DNA at apurinic/apyrimidinic sites (ap sites). Catalytic activity: hydrolysis of DNA containing ring-opened n(7)- methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(n- methyl)formamidopyrimide. YP_694304.1 hyuA and hyuB convert D-and L-substituted hydantoins to corresponding N-carbamyl-amino acids. YP_694305.1 catalyzes the first reaction of fatty acid desaturation YP_694306.1 unknown YP_694308.1 Belongs to the is3/is150/is904 family of transposases and is Involved in the transposition of the insertion sequence. YP_694309.1 unknown YP_694310.1 unknown YP_694311.1 the glycine cleavage system catalyzes the degradation of glycine. the P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO(2). YP_694312.1 the glycine cleavage system catalyzes the degradation of glycine. the P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO(2). YP_694313.1 the glycine cleavage system catalyzes the degradation of glycine. the H protein shuttles the methylamine group of glycine from the P protein to the T protein. YP_694314.1 the glycine cleavage system catalyzes the degradation of glycine. (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH(3) + dihydrolipoylprotein. YP_694319.1 unknown YP_694320.1 hydrolyzes the peptide bond between any amino acid and a penultimate proline residue at the N termini of oligopeptide and protein substrates YP_694324.1 catalyses the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate YP_694325.1 catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. the first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. L-threonine = 2-oxobutanoate + NH(3). YP_694326.1 Ribose-5-phosphate isomerase interconverts ribose-5-phosphate and ribulose-5-phosphate. This enzyme plays essential roles in carbohydrate anabolism and catabolism. YP_694327.1 unknown YP_694328.1 unknown YP_694332.1 d-fructose 1,6-bisphosphate = glycerone phosphate + d-glyceraldehyde 3-phosphate. YP_694333.1 atp + 3-phospho-d-glycerate = adp + 3- phospho-d-glyceroyl phosphate. YP_694334.1 glycolysis and gluconeogenesis by reversibly catalysing the oxidation and phosphorylation of D-glyceraldehyde-3-phosphate to 1,3-diphospho- glycerate YP_694337.1 atp + l-methionine + h(2)o = phosphate + diphosphate + s-adenosyl-l-methionine YP_694338.1 s-adenosyl-l-homocysteine + h(2)o = adenosine + l-homocysteine YP_694339.1 5-methyltetrahydrofolate + acceptor = 5,10-methylenetetrahydrofolate + reduced acceptor. YP_694340.1 Unknown YP_694341.1 Catalyzes the essentially irreversible transphosphorylation from phosphoenolpyruvate (PEP) and ADP to pyruvate and ATP YP_694344.1 unknown YP_694347.1 unknown YP_694350.1 functions as a cation/drug antiporter (by similarity). YP_694352.1 electron transporter YP_694353.1 DNA protection during starvation or oxydative stress transcription regulator protein YP_694355.1 regulation of transcription, DNA-dependent YP_694356.1 unknown YP_694357.1 unknown YP_694358.1 2 glutathione + H2O2 = glutathione disulfide + 2 H2O YP_694360.1 dGTP triphosphohydrolase YP_694363.1 unknown YP_694364.1 unknown YP_694365.1 hydrolase YP_694366.1 unknown YP_694369.1 involved in disulfide-bond formation. required for the functional maturation of secreted virulence factors. transformation. acts by transferring its disulfide bond to other proteins. YP_694370.1 diheme, high potential cytochrome c believed to be an intermediate electron donor to terminal oxidation systems. YP_694371.1 Cytochrome c5 YP_694372.1 necessary for normal cell division and for the maintenance of normal septation (by similarity). YP_694373.1 Transport and binding proteins, Cations YP_694374.1 Transport and binding proteins, Cations YP_694375.1 Transport and binding proteins, Cations YP_694376.1 cation permease YP_694377.1 Transport and binding proteins, Cations YP_694378.1 COG: NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit YP_694379.1 in addition to polymerase activity, this dna polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. it is able to utilize nicked circular duplex dna as a template and can unwind the parental dna strand from its template. n deoxynucleoside triphosphate = n diphosphate + {dna}(n). YP_694385.1 converts mevalonate into acetoacetate and acetyl-coenzyme A (CoA). YP_694386.1 FOG YP_694388.1 L-proline + NAD(P)(+) = L-pyrroline-5-carboxylate + NAD(P)H. YP_694389.1 unknown YP_694390.1 may be involved in pilus retraction YP_694391.1 may be involved in pilus retraction YP_694393.1 unknown YP_694394.1 unknown YP_694395.1 unknown YP_694397.1 unknown YP_694398.1 unknown YP_694399.1 Protein YP_694400.1 Predicted transcriptional regulators YP_694401.1 Phosphate uptake regulator YP_694405.1 ABC YP_694406.1 TRAP-type integral membrane protein, small permease YP_694407.1 TRAP-type large permease YP_694408.1 catalyzes the hydrolysis of acyl-CoA thioesters YP_694409.1 binding extracellular solutes for transport across the bacterial cytoplasmic membrane YP_694410.1 Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the postincision events of nucleotide excision repair and methyl-directed mismatch repair. YP_694411.1 unclear YP_694415.1 unknown YP_694416.1 oxidoreductase YP_694418.1 unknown YP_694420.1 unknown YP_694421.1 catalyzes two consecutive reactions converting 2',3'-cyclic-nucleotide to 3'-nucleotide and then 3'-nucleotide to nucleic acid and phosphate YP_694422.1 Catalyzes efficient strand joining on a single nicked DNA. Catalytic activity: ATP + {deoxyribonucleotide}(n) + {deoxyribonucleotide}(m) = AMP + diphosphate + {deoxyribonucleotide}(n+m). YP_694423.1 has an important function as a repair enzyme for proteins that have been inactivated by oxidation. catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (by similarity). YP_694425.1 a na(+)/h(+) antiporter. probable involved in ph homeostasis and sodium extrusion YP_694426.1 Regulates the alkane oxidation, ATP-dependent transcriptional regulator YP_694427.1 terminal oxidation (hydroxylation) of alkane YP_694428.1 Electron transport YP_694429.1 an aldehyde + nad(+) + h(2)o = an acid + nadh YP_694430.1 converts aliphatic medium-chain-length alcohols into aldehydes. may be linked to the electron transfer chain. alcohol + acceptor = aldehyde + reduced acceptor. YP_694433.1 unknown YP_694435.1 probably facilitates nickel incorporation. YP_694436.1 Urease accessory protein UreF YP_694437.1 urease accesory protein YP_694438.1 acessory protein of urease, that catalyses hydrolysis of urea into ammonia and carbamic acid YP_694439.1 urea + H(2)O = CO(2) + 2 NH(3). YP_694440.1 urea + H(2)O = CO(2) + 2 NH(3). YP_694441.1 urea + H(2)O = CO(2) + 2 NH(3). YP_694442.1 involved in activation of the urease enzyme via the UreD-UreF-UreG-urease complex YP_694443.1 catalyzes the first step in hexosamine metabolism, converting fructose-6p into glucosamine-6p using glutamine as a nitrogen source (by similarity). l-glutamine + d-fructose 6-phosphate = l- glutamate + d-glucosamine 6-phosphate. YP_694444.1 Bifunctional enzyme responsible for the acetylation of glc-n-1-p to give glcnac-1-p and the synthesis of udp-glcnac. First catalytic activity: acetyl-coa + d-glucosamine 1-phosphate = coa + n-acetyl-d-glucosamine 1-phosphate. Second catalytic activity :utp + n-acetyl-alpha-d-glucosamine 1-phosphate = diphosphate + udp-n-acetyl-d-glucosamine. YP_694445.1 produces atp from adp in the presence of a proton gradient across the membrane YP_694446.1 produces atp from adp in the presence of a proton gradient across the membrane. the beta chain is the catalytic subunit YP_694447.1 produces atp from adp in the presence of a proton gradient across the membrane. the gamma chain is believed to be important in regulating atpase activity and the flow of protons through the cf(0) complex YP_694448.1 produces atp from adp in the presence of a proton gradient across the membrane. the alpha chain is a regulatory subunit YP_694449.1 this protein seems to be part of the stalk that links cf(0) to cf(1). it either transmits conformational changes from cf(0) into cf(1) or is implicated in proton conduction YP_694451.1 ATP synthesis YP_694452.1 key component of the proton channel; it may play a direct role in the translocation of protons across the membrane YP_694453.1 component of ATP synthase complex, by sequence similarity YP_694454.1 Predicted transcriptional regulators YP_694455.1 ATPases involved in chromosome/plasmid partitioning, by sequence similarity YP_694456.1 probably involved in the regulation of cell devision YP_694457.1 generally-cell division, not yet known YP_694460.1 unknown YP_694461.1 isocitrate = succinate + glyoxylate YP_694462.1 Biosynthesis of wax esters and triacylglyceroles YP_694463.1 unknown YP_694464.1 transcription regulation, by sequence similarity YP_694466.1 drug resistence, cation/drug antiporter (by similarity). YP_694467.1 Membrane transporter YP_694469.1 (s)-malate = fumarate + h(2)o YP_694470.1 transcriptional regulator YP_694471.1 Unknown YP_694472.1 involved in the biosynthesis of the hypermodified nucleoside 5- methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs (by similarity) YP_694473.1 possible preprotein translocase subunit YidC YP_694474.1 site specific endonuclease that generates mature tRNAs by cleaving-off the leader sequences at their 5'ends YP_694475.1 one of the proteins from the large subunit of the prokaryotic ribosome