-- dump date 20140618_193248 -- class Genbank::misc_feature -- table misc_feature_note -- id note 311403000001 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 311403000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403000003 P-loop; other site 311403000004 Magnesium ion binding site [ion binding]; other site 311403000005 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 311403000006 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403000007 Magnesium ion binding site [ion binding]; other site 311403000008 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 311403000009 ParB-like nuclease domain; Region: ParB; smart00470 311403000010 replication initiation protein RepC; Provisional; Region: PRK13824 311403000011 Replication protein C N-terminal domain; Region: RP-C; pfam03428 311403000012 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 311403000013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403000014 substrate binding pocket [chemical binding]; other site 311403000015 membrane-bound complex binding site; other site 311403000016 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403000017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000018 dimer interface [polypeptide binding]; other site 311403000019 conserved gate region; other site 311403000020 putative PBP binding loops; other site 311403000021 ABC-ATPase subunit interface; other site 311403000022 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403000023 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403000024 Walker A/P-loop; other site 311403000025 ATP binding site [chemical binding]; other site 311403000026 Q-loop/lid; other site 311403000027 ABC transporter signature motif; other site 311403000028 Walker B; other site 311403000029 D-loop; other site 311403000030 H-loop/switch region; other site 311403000031 transcriptional regulator, ArgP family; Region: argP; TIGR03298 311403000032 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403000034 dimerization interface [polypeptide binding]; other site 311403000035 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403000036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000037 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403000038 putative substrate translocation pore; other site 311403000039 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 311403000040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403000041 binding surface 311403000042 TPR motif; other site 311403000043 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 311403000044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403000045 UDP-galactopyranose mutase; Region: GLF; pfam03275 311403000046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 311403000047 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 311403000048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 311403000049 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403000050 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403000051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403000052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403000053 active site 311403000054 phosphorylation site [posttranslational modification] 311403000055 intermolecular recognition site; other site 311403000056 dimerization interface [polypeptide binding]; other site 311403000057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403000058 DNA binding site [nucleotide binding] 311403000059 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 311403000060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403000061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403000062 dimer interface [polypeptide binding]; other site 311403000063 phosphorylation site [posttranslational modification] 311403000064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403000065 Mg2+ binding site [ion binding]; other site 311403000066 G-X-G motif; other site 311403000067 aldehyde dehydrogenase family 7 member; Region: PLN02315 311403000068 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 311403000069 tetrameric interface [polypeptide binding]; other site 311403000070 NAD binding site [chemical binding]; other site 311403000071 catalytic residues [active] 311403000072 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403000073 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403000074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000075 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403000076 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 311403000077 dimerization interface [polypeptide binding]; other site 311403000078 substrate binding pocket [chemical binding]; other site 311403000079 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403000080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000081 dimer interface [polypeptide binding]; other site 311403000082 conserved gate region; other site 311403000083 putative PBP binding loops; other site 311403000084 ABC-ATPase subunit interface; other site 311403000085 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403000086 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403000087 Walker A/P-loop; other site 311403000088 ATP binding site [chemical binding]; other site 311403000089 Q-loop/lid; other site 311403000090 ABC transporter signature motif; other site 311403000091 Walker B; other site 311403000092 D-loop; other site 311403000093 H-loop/switch region; other site 311403000094 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403000095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403000096 substrate binding pocket [chemical binding]; other site 311403000097 membrane-bound complex binding site; other site 311403000098 hinge residues; other site 311403000099 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 311403000100 Predicted transcriptional regulators [Transcription]; Region: COG1695 311403000101 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 311403000102 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 311403000103 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 311403000104 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 311403000105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 311403000106 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 311403000107 GAF domain; Region: GAF; pfam01590 311403000108 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403000109 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 311403000110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403000111 NAD(P) binding site [chemical binding]; other site 311403000112 catalytic residues [active] 311403000113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3564 311403000114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 311403000115 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403000116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403000117 dimer interface [polypeptide binding]; other site 311403000118 putative CheW interface [polypeptide binding]; other site 311403000119 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403000120 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403000121 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 311403000122 putative trimer interface [polypeptide binding]; other site 311403000123 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 311403000124 trimer interface [polypeptide binding]; other site 311403000125 active site 311403000126 substrate binding site [chemical binding]; other site 311403000127 putative CoA binding site [chemical binding]; other site 311403000128 CoA binding site [chemical binding]; other site 311403000129 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 311403000130 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 311403000131 FMN binding site [chemical binding]; other site 311403000132 active site 311403000133 substrate binding site [chemical binding]; other site 311403000134 catalytic residue [active] 311403000135 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 311403000136 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 311403000137 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 311403000138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 311403000139 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403000140 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 311403000141 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 311403000142 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403000143 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403000144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000145 putative PBP binding loops; other site 311403000146 ABC-ATPase subunit interface; other site 311403000147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000148 dimer interface [polypeptide binding]; other site 311403000149 conserved gate region; other site 311403000150 putative PBP binding loops; other site 311403000151 ABC-ATPase subunit interface; other site 311403000152 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403000153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403000154 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403000155 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403000156 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 311403000157 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 311403000158 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403000159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403000160 Walker A/P-loop; other site 311403000161 ATP binding site [chemical binding]; other site 311403000162 Q-loop/lid; other site 311403000163 ABC transporter signature motif; other site 311403000164 Walker B; other site 311403000165 D-loop; other site 311403000166 H-loop/switch region; other site 311403000167 TOBE domain; Region: TOBE_2; pfam08402 311403000168 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 311403000169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403000171 dimerization interface [polypeptide binding]; other site 311403000172 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403000173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403000174 Walker A/P-loop; other site 311403000175 ATP binding site [chemical binding]; other site 311403000176 Q-loop/lid; other site 311403000177 ABC transporter signature motif; other site 311403000178 Walker B; other site 311403000179 D-loop; other site 311403000180 H-loop/switch region; other site 311403000181 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403000182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000183 ABC-ATPase subunit interface; other site 311403000184 putative PBP binding loops; other site 311403000185 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403000186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000187 dimer interface [polypeptide binding]; other site 311403000188 conserved gate region; other site 311403000189 putative PBP binding loops; other site 311403000190 ABC-ATPase subunit interface; other site 311403000191 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403000192 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403000193 substrate binding pocket [chemical binding]; other site 311403000194 membrane-bound complex binding site; other site 311403000195 hinge residues; other site 311403000196 hypothetical protein; Provisional; Region: PRK07475 311403000197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403000198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403000199 active site 311403000200 catalytic tetrad [active] 311403000201 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403000202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000203 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403000204 dimerization interface [polypeptide binding]; other site 311403000205 substrate binding pocket [chemical binding]; other site 311403000206 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403000207 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403000208 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 311403000209 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403000210 Flavin Reductases; Region: FlaRed; cl00801 311403000211 pyrimidine utilization protein D; Region: RutD; TIGR03611 311403000212 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 311403000213 homotrimer interaction site [polypeptide binding]; other site 311403000214 putative active site [active] 311403000215 Isochorismatase family; Region: Isochorismatase; pfam00857 311403000216 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 311403000217 catalytic triad [active] 311403000218 conserved cis-peptide bond; other site 311403000219 pyrimidine utilization protein A; Region: RutA; TIGR03612 311403000220 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403000221 active site 311403000222 dimer interface [polypeptide binding]; other site 311403000223 non-prolyl cis peptide bond; other site 311403000224 insertion regions; other site 311403000225 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403000226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403000227 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 311403000228 Walker A/P-loop; other site 311403000229 ATP binding site [chemical binding]; other site 311403000230 Q-loop/lid; other site 311403000231 ABC transporter signature motif; other site 311403000232 Walker B; other site 311403000233 D-loop; other site 311403000234 H-loop/switch region; other site 311403000235 PAS fold; Region: PAS_4; pfam08448 311403000236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403000237 putative active site [active] 311403000238 heme pocket [chemical binding]; other site 311403000239 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403000240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403000241 metal binding site [ion binding]; metal-binding site 311403000242 active site 311403000243 I-site; other site 311403000244 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403000245 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 311403000246 classical (c) SDRs; Region: SDR_c; cd05233 311403000247 NAD(P) binding site [chemical binding]; other site 311403000248 active site 311403000249 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403000250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403000251 NAD(P) binding site [chemical binding]; other site 311403000252 active site 311403000253 MarR family; Region: MarR_2; pfam12802 311403000254 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403000255 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403000256 nucleotide binding site [chemical binding]; other site 311403000257 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403000258 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403000259 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403000260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403000261 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403000262 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403000263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403000264 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 311403000265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000266 dimer interface [polypeptide binding]; other site 311403000267 conserved gate region; other site 311403000268 putative PBP binding loops; other site 311403000269 ABC-ATPase subunit interface; other site 311403000270 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403000271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000272 dimer interface [polypeptide binding]; other site 311403000273 conserved gate region; other site 311403000274 putative PBP binding loops; other site 311403000275 ABC-ATPase subunit interface; other site 311403000276 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 311403000277 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 311403000278 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 311403000279 inhibitor binding site; inhibition site 311403000280 catalytic Zn binding site [ion binding]; other site 311403000281 structural Zn binding site [ion binding]; other site 311403000282 NADP binding site [chemical binding]; other site 311403000283 tetramer interface [polypeptide binding]; other site 311403000284 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403000285 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403000286 Walker A/P-loop; other site 311403000287 ATP binding site [chemical binding]; other site 311403000288 Q-loop/lid; other site 311403000289 ABC transporter signature motif; other site 311403000290 Walker B; other site 311403000291 D-loop; other site 311403000292 H-loop/switch region; other site 311403000293 TOBE domain; Region: TOBE; pfam03459 311403000294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403000295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403000296 NAD(P) binding site [chemical binding]; other site 311403000297 active site 311403000298 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 311403000299 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 311403000300 homodimer interface [polypeptide binding]; other site 311403000301 substrate-cofactor binding pocket; other site 311403000302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403000303 catalytic residue [active] 311403000304 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 311403000305 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 311403000306 putative ligand binding site [chemical binding]; other site 311403000307 NAD binding site [chemical binding]; other site 311403000308 dimerization interface [polypeptide binding]; other site 311403000309 catalytic site [active] 311403000310 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403000311 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 311403000312 putative metal binding site [ion binding]; other site 311403000313 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 311403000314 conserved cys residue [active] 311403000315 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403000316 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403000317 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 311403000318 active site 311403000319 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 311403000320 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403000321 metal binding site [ion binding]; metal-binding site 311403000322 substrate binding pocket [chemical binding]; other site 311403000323 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 311403000324 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 311403000325 metal binding site [ion binding]; metal-binding site 311403000326 dimer interface [polypeptide binding]; other site 311403000327 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403000328 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403000329 Walker A/P-loop; other site 311403000330 ATP binding site [chemical binding]; other site 311403000331 Q-loop/lid; other site 311403000332 ABC transporter signature motif; other site 311403000333 Walker B; other site 311403000334 D-loop; other site 311403000335 H-loop/switch region; other site 311403000336 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403000337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000338 dimer interface [polypeptide binding]; other site 311403000339 conserved gate region; other site 311403000340 ABC-ATPase subunit interface; other site 311403000341 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403000342 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403000343 substrate binding pocket [chemical binding]; other site 311403000344 membrane-bound complex binding site; other site 311403000345 hinge residues; other site 311403000346 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403000347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403000348 DNA-binding site [nucleotide binding]; DNA binding site 311403000349 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403000350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 311403000351 FCD domain; Region: FCD; pfam07729 311403000352 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403000353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000354 dimer interface [polypeptide binding]; other site 311403000355 conserved gate region; other site 311403000356 putative PBP binding loops; other site 311403000357 ABC-ATPase subunit interface; other site 311403000358 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403000359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403000360 Walker A/P-loop; other site 311403000361 ATP binding site [chemical binding]; other site 311403000362 Q-loop/lid; other site 311403000363 ABC transporter signature motif; other site 311403000364 Walker B; other site 311403000365 D-loop; other site 311403000366 H-loop/switch region; other site 311403000367 TOBE domain; Region: TOBE_2; pfam08402 311403000368 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403000369 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 311403000370 oxidase reductase; Provisional; Region: PTZ00273 311403000371 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 311403000372 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 311403000373 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 311403000374 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403000375 substrate binding site [chemical binding]; other site 311403000376 oxyanion hole (OAH) forming residues; other site 311403000377 trimer interface [polypeptide binding]; other site 311403000378 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 311403000379 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 311403000380 dimer interface [polypeptide binding]; other site 311403000381 PYR/PP interface [polypeptide binding]; other site 311403000382 TPP binding site [chemical binding]; other site 311403000383 substrate binding site [chemical binding]; other site 311403000384 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 311403000385 TPP-binding site [chemical binding]; other site 311403000386 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 311403000387 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 311403000388 FAD binding domain; Region: FAD_binding_4; pfam01565 311403000389 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403000390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403000391 DNA-binding site [nucleotide binding]; DNA binding site 311403000392 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 311403000393 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 311403000394 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 311403000395 NADP binding site [chemical binding]; other site 311403000396 dimer interface [polypeptide binding]; other site 311403000397 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 311403000398 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403000399 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 311403000400 Walker A/P-loop; other site 311403000401 ATP binding site [chemical binding]; other site 311403000402 Q-loop/lid; other site 311403000403 ABC transporter signature motif; other site 311403000404 Walker B; other site 311403000405 D-loop; other site 311403000406 H-loop/switch region; other site 311403000407 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 311403000408 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 311403000409 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403000410 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 311403000411 active site 311403000412 catalytic residues [active] 311403000413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403000415 putative substrate translocation pore; other site 311403000416 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403000417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403000418 DNA-binding site [nucleotide binding]; DNA binding site 311403000419 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 311403000420 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403000421 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403000422 inhibitor site; inhibition site 311403000423 active site 311403000424 dimer interface [polypeptide binding]; other site 311403000425 catalytic residue [active] 311403000426 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 311403000427 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 311403000428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 311403000429 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 311403000430 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403000431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403000432 substrate binding pocket [chemical binding]; other site 311403000433 membrane-bound complex binding site; other site 311403000434 hinge residues; other site 311403000435 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000437 dimer interface [polypeptide binding]; other site 311403000438 conserved gate region; other site 311403000439 putative PBP binding loops; other site 311403000440 ABC-ATPase subunit interface; other site 311403000441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403000442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000443 putative PBP binding loops; other site 311403000444 dimer interface [polypeptide binding]; other site 311403000445 ABC-ATPase subunit interface; other site 311403000446 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403000447 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403000448 Walker A/P-loop; other site 311403000449 ATP binding site [chemical binding]; other site 311403000450 Q-loop/lid; other site 311403000451 ABC transporter signature motif; other site 311403000452 Walker B; other site 311403000453 D-loop; other site 311403000454 H-loop/switch region; other site 311403000455 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403000456 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403000457 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403000458 putative active site [active] 311403000459 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 311403000460 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403000461 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403000462 Walker A/P-loop; other site 311403000463 ATP binding site [chemical binding]; other site 311403000464 Q-loop/lid; other site 311403000465 ABC transporter signature motif; other site 311403000466 Walker B; other site 311403000467 D-loop; other site 311403000468 H-loop/switch region; other site 311403000469 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403000470 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 311403000471 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403000472 Walker A/P-loop; other site 311403000473 ATP binding site [chemical binding]; other site 311403000474 Q-loop/lid; other site 311403000475 ABC transporter signature motif; other site 311403000476 Walker B; other site 311403000477 D-loop; other site 311403000478 H-loop/switch region; other site 311403000479 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403000480 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403000481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000482 putative PBP binding loops; other site 311403000483 dimer interface [polypeptide binding]; other site 311403000484 ABC-ATPase subunit interface; other site 311403000485 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403000486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000487 dimer interface [polypeptide binding]; other site 311403000488 conserved gate region; other site 311403000489 putative PBP binding loops; other site 311403000490 ABC-ATPase subunit interface; other site 311403000491 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 311403000492 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403000493 hypothetical protein; Provisional; Region: PRK11171 311403000494 Cupin domain; Region: Cupin_2; pfam07883 311403000495 Cupin domain; Region: Cupin_2; pfam07883 311403000496 transcriptional regulator; Provisional; Region: PRK10632 311403000497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000498 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403000499 putative effector binding pocket; other site 311403000500 dimerization interface [polypeptide binding]; other site 311403000501 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 311403000502 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 311403000503 Trp docking motif [polypeptide binding]; other site 311403000504 putative active site [active] 311403000505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403000506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000508 putative substrate translocation pore; other site 311403000509 MFS/sugar transport protein; Region: MFS_2; pfam13347 311403000510 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 311403000511 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 311403000512 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 311403000513 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 311403000514 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 311403000515 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 311403000516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403000517 dimerization interface [polypeptide binding]; other site 311403000518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403000519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403000520 dimer interface [polypeptide binding]; other site 311403000521 putative CheW interface [polypeptide binding]; other site 311403000522 hypothetical protein; Provisional; Region: PRK07236 311403000523 FAD binding domain; Region: FAD_binding_3; pfam01494 311403000524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403000525 MarR family; Region: MarR; pfam01047 311403000526 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 311403000527 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 311403000528 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 311403000529 active site 311403000530 dimer interface [polypeptide binding]; other site 311403000531 metal binding site [ion binding]; metal-binding site 311403000532 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 311403000533 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 311403000534 dimer interface [polypeptide binding]; other site 311403000535 active site 311403000536 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 311403000537 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403000538 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 311403000539 Flavin binding site [chemical binding]; other site 311403000540 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 311403000541 MarR family; Region: MarR_2; cl17246 311403000542 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403000543 benzoate transport; Region: 2A0115; TIGR00895 311403000544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000545 putative substrate translocation pore; other site 311403000546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000547 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403000548 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403000549 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 311403000550 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403000551 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 311403000552 Domain of unknown function (DUF336); Region: DUF336; pfam03928 311403000553 Predicted flavoprotein [General function prediction only]; Region: COG0431 311403000554 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403000555 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403000556 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403000557 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 311403000558 putative CheA interaction surface; other site 311403000559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 311403000560 Integrase core domain; Region: rve; pfam00665 311403000561 Response regulator receiver domain; Region: Response_reg; pfam00072 311403000562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403000563 active site 311403000564 phosphorylation site [posttranslational modification] 311403000565 intermolecular recognition site; other site 311403000566 dimerization interface [polypeptide binding]; other site 311403000567 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 311403000568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403000569 active site 311403000570 phosphorylation site [posttranslational modification] 311403000571 intermolecular recognition site; other site 311403000572 dimerization interface [polypeptide binding]; other site 311403000573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403000574 DNA binding residues [nucleotide binding] 311403000575 dimerization interface [polypeptide binding]; other site 311403000576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403000577 dimer interface [polypeptide binding]; other site 311403000578 phosphorylation site [posttranslational modification] 311403000579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403000580 ATP binding site [chemical binding]; other site 311403000581 Mg2+ binding site [ion binding]; other site 311403000582 G-X-G motif; other site 311403000583 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 311403000584 Cupin; Region: Cupin_1; smart00835 311403000585 Cupin; Region: Cupin_1; smart00835 311403000586 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 311403000587 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403000588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403000589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403000590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403000591 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 311403000592 TadE-like protein; Region: TadE; pfam07811 311403000593 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 311403000594 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 311403000595 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 311403000596 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403000597 metal binding site [ion binding]; metal-binding site 311403000598 active site 311403000599 I-site; other site 311403000600 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403000601 Cupin domain; Region: Cupin_2; pfam07883 311403000602 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403000603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403000604 putative DNA binding site [nucleotide binding]; other site 311403000605 putative Zn2+ binding site [ion binding]; other site 311403000606 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403000607 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 311403000608 active site 311403000609 hypothetical protein; Provisional; Region: PRK06847 311403000610 hypothetical protein; Provisional; Region: PRK07236 311403000611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 311403000612 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 311403000613 acyl-activating enzyme (AAE) consensus motif; other site 311403000614 AMP binding site [chemical binding]; other site 311403000615 active site 311403000616 CoA binding site [chemical binding]; other site 311403000617 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 311403000618 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403000619 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 311403000620 maleylacetoacetate isomerase; Region: maiA; TIGR01262 311403000621 C-terminal domain interface [polypeptide binding]; other site 311403000622 GSH binding site (G-site) [chemical binding]; other site 311403000623 putative dimer interface [polypeptide binding]; other site 311403000624 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 311403000625 dimer interface [polypeptide binding]; other site 311403000626 N-terminal domain interface [polypeptide binding]; other site 311403000627 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 311403000628 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 311403000629 Cupin domain; Region: Cupin_2; pfam07883 311403000630 Cupin domain; Region: Cupin_2; pfam07883 311403000631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 311403000632 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 311403000633 active site 311403000634 metal binding site [ion binding]; metal-binding site 311403000635 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 311403000636 active site 311403000637 metal binding site [ion binding]; metal-binding site 311403000638 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 311403000639 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403000640 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 311403000641 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 311403000642 classical (c) SDRs; Region: SDR_c; cd05233 311403000643 NAD(P) binding site [chemical binding]; other site 311403000644 active site 311403000645 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403000646 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403000647 TM-ABC transporter signature motif; other site 311403000648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403000649 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403000650 ligand binding site [chemical binding]; other site 311403000651 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403000652 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403000653 Walker A/P-loop; other site 311403000654 ATP binding site [chemical binding]; other site 311403000655 Q-loop/lid; other site 311403000656 ABC transporter signature motif; other site 311403000657 Walker B; other site 311403000658 D-loop; other site 311403000659 H-loop/switch region; other site 311403000660 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403000661 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 311403000662 dimer interface [polypeptide binding]; other site 311403000663 substrate binding site [chemical binding]; other site 311403000664 metal binding site [ion binding]; metal-binding site 311403000665 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403000666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403000667 DNA-binding site [nucleotide binding]; DNA binding site 311403000668 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 311403000669 phenol 2-monooxygenase; Provisional; Region: PRK08294 311403000670 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403000671 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 311403000672 dimer interface [polypeptide binding]; other site 311403000673 NMT1/THI5 like; Region: NMT1; pfam09084 311403000674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 311403000675 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 311403000676 NMT1/THI5 like; Region: NMT1; pfam09084 311403000677 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403000678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000679 dimer interface [polypeptide binding]; other site 311403000680 conserved gate region; other site 311403000681 putative PBP binding loops; other site 311403000682 ABC-ATPase subunit interface; other site 311403000683 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 311403000684 ABC-ATPase subunit interface; other site 311403000685 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403000686 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403000687 Walker A/P-loop; other site 311403000688 ATP binding site [chemical binding]; other site 311403000689 Q-loop/lid; other site 311403000690 ABC transporter signature motif; other site 311403000691 Walker B; other site 311403000692 D-loop; other site 311403000693 H-loop/switch region; other site 311403000694 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 311403000695 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403000696 PYR/PP interface [polypeptide binding]; other site 311403000697 dimer interface [polypeptide binding]; other site 311403000698 TPP binding site [chemical binding]; other site 311403000699 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 311403000700 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 311403000701 TPP-binding site [chemical binding]; other site 311403000702 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403000703 Nocardioides 2-carboxybenzaldehyde dehydrogenase, PhdK-like; Region: ALDH_PhdK-like; cd07107 311403000704 NAD(P) binding site [chemical binding]; other site 311403000705 catalytic residues [active] 311403000706 catalytic residues [active] 311403000707 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 311403000708 intersubunit interface [polypeptide binding]; other site 311403000709 active site 311403000710 Zn2+ binding site [ion binding]; other site 311403000711 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403000712 MarR family; Region: MarR_2; pfam12802 311403000713 ornithine cyclodeaminase; Validated; Region: PRK06141 311403000714 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 311403000715 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 311403000716 homotrimer interaction site [polypeptide binding]; other site 311403000717 putative active site [active] 311403000718 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 311403000719 metabolite-proton symporter; Region: 2A0106; TIGR00883 311403000720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000721 putative substrate translocation pore; other site 311403000722 allantoate amidohydrolase; Reviewed; Region: PRK12893 311403000723 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 311403000724 active site 311403000725 metal binding site [ion binding]; metal-binding site 311403000726 dimer interface [polypeptide binding]; other site 311403000727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403000728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403000730 dimerization interface [polypeptide binding]; other site 311403000731 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 311403000732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000733 putative substrate translocation pore; other site 311403000734 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 311403000735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000736 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 311403000737 dimerization interface [polypeptide binding]; other site 311403000738 substrate binding pocket [chemical binding]; other site 311403000739 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 311403000740 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403000741 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403000742 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 311403000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000744 putative substrate translocation pore; other site 311403000745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403000746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403000748 dimerization interface [polypeptide binding]; other site 311403000749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403000750 DoxX-like family; Region: DoxX_2; pfam13564 311403000751 Cupin domain; Region: Cupin_2; pfam07883 311403000752 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403000753 Epoxide hydrolase N terminus; Region: EHN; pfam06441 311403000754 Pirin; Region: Pirin; pfam02678 311403000755 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 311403000756 Isochorismatase family; Region: Isochorismatase; pfam00857 311403000757 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 311403000758 catalytic triad [active] 311403000759 conserved cis-peptide bond; other site 311403000760 Pirin; Region: Pirin; pfam02678 311403000761 Pirin-related protein [General function prediction only]; Region: COG1741 311403000762 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 311403000763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403000764 DNA-binding site [nucleotide binding]; DNA binding site 311403000765 FCD domain; Region: FCD; pfam07729 311403000766 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 311403000767 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 311403000768 active site 311403000769 catalytic residues [active] 311403000770 metal binding site [ion binding]; metal-binding site 311403000771 DmpG-like communication domain; Region: DmpG_comm; pfam07836 311403000772 acetaldehyde dehydrogenase; Validated; Region: PRK08300 311403000773 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 311403000774 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 311403000775 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 311403000776 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 311403000777 active site 311403000778 FMN binding site [chemical binding]; other site 311403000779 substrate binding site [chemical binding]; other site 311403000780 putative catalytic residue [active] 311403000781 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 311403000782 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 311403000783 active site 311403000784 metal binding site [ion binding]; metal-binding site 311403000785 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 311403000786 active site 311403000787 metal binding site [ion binding]; metal-binding site 311403000788 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 311403000789 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403000790 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 311403000791 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 311403000792 NAD binding site [chemical binding]; other site 311403000793 catalytic residues [active] 311403000794 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 311403000795 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 311403000796 N-terminal domain of 2,3-dihydroxy-p-cumate-3,4-dioxygenase (PpCmtC); Region: PpCmtC_N; cd08361 311403000797 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403000798 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 311403000799 active site 311403000800 metal binding site [ion binding]; metal-binding site 311403000801 N-terminal domain of 2,3-dihydroxy-p-cumate-3,4-dioxygenase (PpCmtC); Region: PpCmtC_N; cd08361 311403000802 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 311403000803 C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343 311403000804 active site 311403000805 metal binding site [ion binding]; metal-binding site 311403000806 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 311403000807 intersubunit interface [polypeptide binding]; other site 311403000808 active site 311403000809 Zn2+ binding site [ion binding]; other site 311403000810 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 311403000811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000812 putative substrate translocation pore; other site 311403000813 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403000814 Epoxide hydrolase N terminus; Region: EHN; pfam06441 311403000815 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403000816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403000817 classical (c) SDRs; Region: SDR_c; cd05233 311403000818 NAD(P) binding site [chemical binding]; other site 311403000819 active site 311403000820 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 311403000821 putative hydrophobic ligand binding site [chemical binding]; other site 311403000822 short chain dehydrogenase; Provisional; Region: PRK06172 311403000823 classical (c) SDRs; Region: SDR_c; cd05233 311403000824 NAD(P) binding site [chemical binding]; other site 311403000825 active site 311403000826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403000827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000828 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403000829 putative effector binding pocket; other site 311403000830 dimerization interface [polypeptide binding]; other site 311403000831 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403000832 classical (c) SDRs; Region: SDR_c; cd05233 311403000833 NAD(P) binding site [chemical binding]; other site 311403000834 active site 311403000835 Pirin; Region: Pirin; pfam02678 311403000836 Pirin-related protein [General function prediction only]; Region: COG1741 311403000837 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 311403000838 Isochorismatase family; Region: Isochorismatase; pfam00857 311403000839 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 311403000840 catalytic triad [active] 311403000841 conserved cis-peptide bond; other site 311403000842 LysR family transcriptional regulator; Provisional; Region: PRK14997 311403000843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000844 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403000845 putative effector binding pocket; other site 311403000846 dimerization interface [polypeptide binding]; other site 311403000847 transcriptional regulator; Provisional; Region: PRK10632 311403000848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403000849 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403000850 putative effector binding pocket; other site 311403000851 dimerization interface [polypeptide binding]; other site 311403000852 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 311403000853 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403000854 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403000855 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 311403000856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000857 putative substrate translocation pore; other site 311403000858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403000859 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403000860 cyclase homology domain; Region: CHD; cd07302 311403000861 nucleotidyl binding site; other site 311403000862 metal binding site [ion binding]; metal-binding site 311403000863 dimer interface [polypeptide binding]; other site 311403000864 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 311403000865 EamA-like transporter family; Region: EamA; pfam00892 311403000866 EamA-like transporter family; Region: EamA; pfam00892 311403000867 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403000868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403000869 DNA-binding site [nucleotide binding]; DNA binding site 311403000870 FCD domain; Region: FCD; pfam07729 311403000871 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 311403000872 homotrimer interaction site [polypeptide binding]; other site 311403000873 putative active site [active] 311403000874 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 311403000875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403000876 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 311403000877 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403000878 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403000879 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403000880 TM-ABC transporter signature motif; other site 311403000881 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403000882 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403000883 TM-ABC transporter signature motif; other site 311403000884 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403000885 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403000886 Walker A/P-loop; other site 311403000887 ATP binding site [chemical binding]; other site 311403000888 Q-loop/lid; other site 311403000889 ABC transporter signature motif; other site 311403000890 Walker B; other site 311403000891 D-loop; other site 311403000892 H-loop/switch region; other site 311403000893 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403000894 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403000895 Walker A/P-loop; other site 311403000896 ATP binding site [chemical binding]; other site 311403000897 Q-loop/lid; other site 311403000898 ABC transporter signature motif; other site 311403000899 Walker B; other site 311403000900 D-loop; other site 311403000901 H-loop/switch region; other site 311403000902 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 311403000903 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403000904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403000905 DNA-binding site [nucleotide binding]; DNA binding site 311403000906 FCD domain; Region: FCD; pfam07729 311403000907 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 311403000908 homotrimer interaction site [polypeptide binding]; other site 311403000909 putative active site [active] 311403000910 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403000911 classical (c) SDRs; Region: SDR_c; cd05233 311403000912 NAD(P) binding site [chemical binding]; other site 311403000913 active site 311403000914 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403000915 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403000916 Walker A/P-loop; other site 311403000917 ATP binding site [chemical binding]; other site 311403000918 Q-loop/lid; other site 311403000919 ABC transporter signature motif; other site 311403000920 Walker B; other site 311403000921 D-loop; other site 311403000922 H-loop/switch region; other site 311403000923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000924 dimer interface [polypeptide binding]; other site 311403000925 conserved gate region; other site 311403000926 putative PBP binding loops; other site 311403000927 ABC-ATPase subunit interface; other site 311403000928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000929 dimer interface [polypeptide binding]; other site 311403000930 conserved gate region; other site 311403000931 putative PBP binding loops; other site 311403000932 ABC-ATPase subunit interface; other site 311403000933 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403000934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403000935 substrate binding pocket [chemical binding]; other site 311403000936 membrane-bound complex binding site; other site 311403000937 hinge residues; other site 311403000938 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 311403000939 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403000940 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 311403000941 short chain dehydrogenase; Provisional; Region: PRK06138 311403000942 classical (c) SDRs; Region: SDR_c; cd05233 311403000943 NAD(P) binding site [chemical binding]; other site 311403000944 active site 311403000945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403000946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403000947 DNA binding residues [nucleotide binding] 311403000948 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403000949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000950 dimer interface [polypeptide binding]; other site 311403000951 conserved gate region; other site 311403000952 putative PBP binding loops; other site 311403000953 ABC-ATPase subunit interface; other site 311403000954 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403000955 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403000956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403000957 dimer interface [polypeptide binding]; other site 311403000958 conserved gate region; other site 311403000959 putative PBP binding loops; other site 311403000960 ABC-ATPase subunit interface; other site 311403000961 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403000962 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403000963 Walker A/P-loop; other site 311403000964 ATP binding site [chemical binding]; other site 311403000965 Q-loop/lid; other site 311403000966 ABC transporter signature motif; other site 311403000967 Walker B; other site 311403000968 D-loop; other site 311403000969 H-loop/switch region; other site 311403000970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403000971 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403000972 Walker A/P-loop; other site 311403000973 ATP binding site [chemical binding]; other site 311403000974 Q-loop/lid; other site 311403000975 ABC transporter signature motif; other site 311403000976 Walker B; other site 311403000977 D-loop; other site 311403000978 H-loop/switch region; other site 311403000979 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403000980 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 311403000981 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403000982 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403000983 Uncharacterized conserved protein [Function unknown]; Region: COG3535 311403000984 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403000985 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 311403000986 Uncharacterized conserved protein [Function unknown]; Region: COG3535 311403000987 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 311403000988 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403000989 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403000990 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 311403000991 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 311403000992 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 311403000993 active site 311403000994 dimer interface [polypeptide binding]; other site 311403000995 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 311403000996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403000997 active site 311403000998 phosphorylation site [posttranslational modification] 311403000999 intermolecular recognition site; other site 311403001000 dimerization interface [polypeptide binding]; other site 311403001001 PAS domain; Region: PAS; smart00091 311403001002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403001003 PAS domain; Region: PAS_9; pfam13426 311403001004 putative active site [active] 311403001005 heme pocket [chemical binding]; other site 311403001006 PAS domain S-box; Region: sensory_box; TIGR00229 311403001007 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403001008 putative active site [active] 311403001009 heme pocket [chemical binding]; other site 311403001010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403001011 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403001012 DNA binding residues [nucleotide binding] 311403001013 dimerization interface [polypeptide binding]; other site 311403001014 CsbD-like; Region: CsbD; pfam05532 311403001015 BON domain; Region: BON; pfam04972 311403001016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403001017 PAS domain; Region: PAS_9; pfam13426 311403001018 putative active site [active] 311403001019 heme pocket [chemical binding]; other site 311403001020 PAS domain S-box; Region: sensory_box; TIGR00229 311403001021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403001022 putative active site [active] 311403001023 heme pocket [chemical binding]; other site 311403001024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 311403001025 HWE histidine kinase; Region: HWE_HK; cl06527 311403001026 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 311403001027 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 311403001028 heme binding pocket [chemical binding]; other site 311403001029 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 311403001030 domain interactions; other site 311403001031 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403001032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403001033 non-specific DNA binding site [nucleotide binding]; other site 311403001034 salt bridge; other site 311403001035 sequence-specific DNA binding site [nucleotide binding]; other site 311403001036 Cupin domain; Region: Cupin_2; pfam07883 311403001037 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403001038 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403001039 substrate binding pocket [chemical binding]; other site 311403001040 membrane-bound complex binding site; other site 311403001041 hinge residues; other site 311403001042 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403001043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001044 dimer interface [polypeptide binding]; other site 311403001045 conserved gate region; other site 311403001046 ABC-ATPase subunit interface; other site 311403001047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001048 dimer interface [polypeptide binding]; other site 311403001049 conserved gate region; other site 311403001050 putative PBP binding loops; other site 311403001051 ABC-ATPase subunit interface; other site 311403001052 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403001053 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403001054 Walker A/P-loop; other site 311403001055 ATP binding site [chemical binding]; other site 311403001056 Q-loop/lid; other site 311403001057 ABC transporter signature motif; other site 311403001058 Walker B; other site 311403001059 D-loop; other site 311403001060 H-loop/switch region; other site 311403001061 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 311403001062 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 311403001063 homodimer interface [polypeptide binding]; other site 311403001064 substrate-cofactor binding pocket; other site 311403001065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403001066 catalytic residue [active] 311403001067 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 311403001068 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403001069 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403001070 TM-ABC transporter signature motif; other site 311403001071 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403001072 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403001073 TM-ABC transporter signature motif; other site 311403001074 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 311403001075 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403001076 Walker A/P-loop; other site 311403001077 ATP binding site [chemical binding]; other site 311403001078 Q-loop/lid; other site 311403001079 ABC transporter signature motif; other site 311403001080 Walker B; other site 311403001081 D-loop; other site 311403001082 H-loop/switch region; other site 311403001083 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403001084 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 311403001085 Amidase; Region: Amidase; cl11426 311403001086 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 311403001087 putative ligand binding site [chemical binding]; other site 311403001088 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 311403001089 carboxy-terminal protease; Provisional; Region: PRK11186 311403001090 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 311403001091 protein binding site [polypeptide binding]; other site 311403001092 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 311403001093 Catalytic dyad [active] 311403001094 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 311403001095 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403001096 classical (c) SDRs; Region: SDR_c; cd05233 311403001097 NAD(P) binding site [chemical binding]; other site 311403001098 active site 311403001099 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 311403001100 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 311403001101 hypothetical protein; Validated; Region: PRK06201 311403001102 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 311403001103 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403001104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001105 dimer interface [polypeptide binding]; other site 311403001106 conserved gate region; other site 311403001107 putative PBP binding loops; other site 311403001108 ABC-ATPase subunit interface; other site 311403001109 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 311403001110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001111 dimer interface [polypeptide binding]; other site 311403001112 conserved gate region; other site 311403001113 putative PBP binding loops; other site 311403001114 ABC-ATPase subunit interface; other site 311403001115 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403001116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001117 Walker A/P-loop; other site 311403001118 ATP binding site [chemical binding]; other site 311403001119 Q-loop/lid; other site 311403001120 ABC transporter signature motif; other site 311403001121 Walker B; other site 311403001122 D-loop; other site 311403001123 H-loop/switch region; other site 311403001124 TOBE domain; Region: TOBE_2; pfam08402 311403001125 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403001126 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403001127 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 311403001128 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 311403001129 putative ligand binding site [chemical binding]; other site 311403001130 NAD binding site [chemical binding]; other site 311403001131 dimerization interface [polypeptide binding]; other site 311403001132 catalytic site [active] 311403001133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403001134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403001136 dimerization interface [polypeptide binding]; other site 311403001137 Creatinine amidohydrolase; Region: Creatininase; pfam02633 311403001138 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 311403001139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403001140 Walker A/P-loop; other site 311403001141 ATP binding site [chemical binding]; other site 311403001142 Q-loop/lid; other site 311403001143 ABC transporter signature motif; other site 311403001144 Walker B; other site 311403001145 D-loop; other site 311403001146 H-loop/switch region; other site 311403001147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403001148 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403001149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001150 dimer interface [polypeptide binding]; other site 311403001151 conserved gate region; other site 311403001152 putative PBP binding loops; other site 311403001153 ABC-ATPase subunit interface; other site 311403001154 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403001155 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403001156 Walker A/P-loop; other site 311403001157 ATP binding site [chemical binding]; other site 311403001158 Q-loop/lid; other site 311403001159 ABC transporter signature motif; other site 311403001160 Walker B; other site 311403001161 D-loop; other site 311403001162 H-loop/switch region; other site 311403001163 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403001164 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403001165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001166 dimer interface [polypeptide binding]; other site 311403001167 conserved gate region; other site 311403001168 putative PBP binding loops; other site 311403001169 ABC-ATPase subunit interface; other site 311403001170 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403001171 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 311403001172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403001173 non-specific DNA binding site [nucleotide binding]; other site 311403001174 salt bridge; other site 311403001175 sequence-specific DNA binding site [nucleotide binding]; other site 311403001176 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 311403001177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403001179 dimerization interface [polypeptide binding]; other site 311403001180 Lysine efflux permease [General function prediction only]; Region: COG1279 311403001181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403001182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001183 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403001184 putative effector binding pocket; other site 311403001185 dimerization interface [polypeptide binding]; other site 311403001186 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 311403001187 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 311403001188 putative active site [active] 311403001189 metal binding site [ion binding]; metal-binding site 311403001190 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 311403001191 C-terminal domain interface [polypeptide binding]; other site 311403001192 GSH binding site (G-site) [chemical binding]; other site 311403001193 dimer interface [polypeptide binding]; other site 311403001194 Predicted membrane protein [Function unknown]; Region: COG2259 311403001195 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 311403001196 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403001197 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 311403001198 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 311403001199 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 311403001200 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403001201 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403001202 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 311403001203 Protein export membrane protein; Region: SecD_SecF; cl14618 311403001204 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403001205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403001206 active site 311403001207 phosphorylation site [posttranslational modification] 311403001208 intermolecular recognition site; other site 311403001209 dimerization interface [polypeptide binding]; other site 311403001210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403001211 DNA binding site [nucleotide binding] 311403001212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403001213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403001214 dimerization interface [polypeptide binding]; other site 311403001215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403001216 ATP binding site [chemical binding]; other site 311403001217 Mg2+ binding site [ion binding]; other site 311403001218 G-X-G motif; other site 311403001219 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 311403001220 thiamine phosphate binding site [chemical binding]; other site 311403001221 active site 311403001222 pyrophosphate binding site [ion binding]; other site 311403001223 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 311403001224 ThiS interaction site; other site 311403001225 putative active site [active] 311403001226 tetramer interface [polypeptide binding]; other site 311403001227 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 311403001228 thiS-thiF/thiG interaction site; other site 311403001229 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403001230 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 311403001231 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 311403001232 ThiC-associated domain; Region: ThiC-associated; pfam13667 311403001233 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 311403001234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403001235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403001236 DNA binding site [nucleotide binding] 311403001237 domain linker motif; other site 311403001238 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 311403001239 putative dimerization interface [polypeptide binding]; other site 311403001240 putative ligand binding site [chemical binding]; other site 311403001241 EthD domain; Region: EthD; cl17553 311403001242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403001243 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403001244 substrate binding pocket [chemical binding]; other site 311403001245 membrane-bound complex binding site; other site 311403001246 hinge residues; other site 311403001247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001248 dimer interface [polypeptide binding]; other site 311403001249 conserved gate region; other site 311403001250 ABC-ATPase subunit interface; other site 311403001251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001252 dimer interface [polypeptide binding]; other site 311403001253 conserved gate region; other site 311403001254 putative PBP binding loops; other site 311403001255 ABC-ATPase subunit interface; other site 311403001256 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403001257 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403001258 Walker A/P-loop; other site 311403001259 ATP binding site [chemical binding]; other site 311403001260 Q-loop/lid; other site 311403001261 ABC transporter signature motif; other site 311403001262 Walker B; other site 311403001263 D-loop; other site 311403001264 H-loop/switch region; other site 311403001265 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 311403001266 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 311403001267 putative ligand binding site [chemical binding]; other site 311403001268 NAD binding site [chemical binding]; other site 311403001269 catalytic site [active] 311403001270 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403001271 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403001272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001273 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403001274 dimerization interface [polypeptide binding]; other site 311403001275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403001276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403001277 substrate binding pocket [chemical binding]; other site 311403001278 membrane-bound complex binding site; other site 311403001279 hinge residues; other site 311403001280 hypothetical protein; Provisional; Region: PRK07475 311403001281 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403001282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001283 dimer interface [polypeptide binding]; other site 311403001284 conserved gate region; other site 311403001285 putative PBP binding loops; other site 311403001286 ABC-ATPase subunit interface; other site 311403001287 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403001288 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403001289 Walker A/P-loop; other site 311403001290 ATP binding site [chemical binding]; other site 311403001291 Q-loop/lid; other site 311403001292 ABC transporter signature motif; other site 311403001293 Walker B; other site 311403001294 D-loop; other site 311403001295 H-loop/switch region; other site 311403001296 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403001297 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403001298 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403001299 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403001300 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 311403001301 AsnC family; Region: AsnC_trans_reg; pfam01037 311403001302 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 311403001303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403001304 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403001305 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403001306 substrate binding pocket [chemical binding]; other site 311403001307 membrane-bound complex binding site; other site 311403001308 hinge residues; other site 311403001309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403001310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403001311 active site 311403001312 catalytic tetrad [active] 311403001313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403001314 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 311403001315 putative substrate translocation pore; other site 311403001316 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 311403001317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403001318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001319 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403001320 putative effector binding pocket; other site 311403001321 putative dimerization interface [polypeptide binding]; other site 311403001322 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 311403001323 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 311403001324 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 311403001325 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 311403001326 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403001327 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 311403001328 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 311403001329 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 311403001330 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403001331 catalytic loop [active] 311403001332 iron binding site [ion binding]; other site 311403001333 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 311403001334 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 311403001335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 311403001336 putative substrate translocation pore; other site 311403001337 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403001338 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403001339 ligand binding site [chemical binding]; other site 311403001340 flexible hinge region; other site 311403001341 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 311403001342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403001343 putative substrate translocation pore; other site 311403001344 putative acetyltransferase; Provisional; Region: PRK03624 311403001345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403001346 Coenzyme A binding pocket [chemical binding]; other site 311403001347 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 311403001348 peptidase T; Region: peptidase-T; TIGR01882 311403001349 metal binding site [ion binding]; metal-binding site 311403001350 dimer interface [polypeptide binding]; other site 311403001351 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 311403001352 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 311403001353 putative active site [active] 311403001354 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403001355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001356 Walker A/P-loop; other site 311403001357 ATP binding site [chemical binding]; other site 311403001358 Q-loop/lid; other site 311403001359 ABC transporter signature motif; other site 311403001360 Walker B; other site 311403001361 D-loop; other site 311403001362 H-loop/switch region; other site 311403001363 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 311403001364 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 311403001365 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403001366 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 311403001367 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 311403001368 substrate binding site [chemical binding]; other site 311403001369 dimer interface [polypeptide binding]; other site 311403001370 triosephosphate isomerase; Provisional; Region: PRK14565 311403001371 catalytic triad [active] 311403001372 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403001373 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403001374 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403001375 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403001376 PCI domain; Region: PCI; cl02111 311403001377 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403001378 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403001379 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 311403001380 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 311403001381 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 311403001382 putative N- and C-terminal domain interface [polypeptide binding]; other site 311403001383 putative active site [active] 311403001384 MgATP binding site [chemical binding]; other site 311403001385 catalytic site [active] 311403001386 metal binding site [ion binding]; metal-binding site 311403001387 putative xylulose binding site [chemical binding]; other site 311403001388 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 311403001389 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403001390 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403001391 Walker A/P-loop; other site 311403001392 ATP binding site [chemical binding]; other site 311403001393 Q-loop/lid; other site 311403001394 ABC transporter signature motif; other site 311403001395 Walker B; other site 311403001396 D-loop; other site 311403001397 H-loop/switch region; other site 311403001398 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403001399 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403001400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403001401 TM-ABC transporter signature motif; other site 311403001402 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403001403 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 311403001404 ligand binding site [chemical binding]; other site 311403001405 dimerization interface [polypeptide binding]; other site 311403001406 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403001407 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403001408 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403001409 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 311403001410 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 311403001411 putative N- and C-terminal domain interface [polypeptide binding]; other site 311403001412 putative active site [active] 311403001413 MgATP binding site [chemical binding]; other site 311403001414 catalytic site [active] 311403001415 metal binding site [ion binding]; metal-binding site 311403001416 putative xylulose binding site [chemical binding]; other site 311403001417 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 311403001418 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 311403001419 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 311403001420 intersubunit interface [polypeptide binding]; other site 311403001421 active site 311403001422 zinc binding site [ion binding]; other site 311403001423 Na+ binding site [ion binding]; other site 311403001424 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 311403001425 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403001426 carboxyltransferase (CT) interaction site; other site 311403001427 biotinylation site [posttranslational modification]; other site 311403001428 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 311403001429 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403001430 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 311403001431 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 311403001432 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 311403001433 lipoyl-biotinyl attachment site [posttranslational modification]; other site 311403001434 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 311403001435 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 311403001436 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 311403001437 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 311403001438 putative active site [active] 311403001439 aspartate aminotransferase; Provisional; Region: PRK05764 311403001440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403001441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403001442 homodimer interface [polypeptide binding]; other site 311403001443 catalytic residue [active] 311403001444 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 311403001445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001446 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 311403001447 putative dimerization interface [polypeptide binding]; other site 311403001448 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 311403001449 classical (c) SDRs; Region: SDR_c; cd05233 311403001450 NAD(P) binding site [chemical binding]; other site 311403001451 active site 311403001452 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403001453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001454 dimer interface [polypeptide binding]; other site 311403001455 conserved gate region; other site 311403001456 putative PBP binding loops; other site 311403001457 ABC-ATPase subunit interface; other site 311403001458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001459 dimer interface [polypeptide binding]; other site 311403001460 conserved gate region; other site 311403001461 putative PBP binding loops; other site 311403001462 ABC-ATPase subunit interface; other site 311403001463 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403001464 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403001465 Walker A/P-loop; other site 311403001466 ATP binding site [chemical binding]; other site 311403001467 Q-loop/lid; other site 311403001468 ABC transporter signature motif; other site 311403001469 Walker B; other site 311403001470 D-loop; other site 311403001471 H-loop/switch region; other site 311403001472 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403001473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403001474 substrate binding pocket [chemical binding]; other site 311403001475 membrane-bound complex binding site; other site 311403001476 hinge residues; other site 311403001477 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 311403001478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403001479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001480 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 311403001481 putative substrate binding pocket [chemical binding]; other site 311403001482 dimerization interface [polypeptide binding]; other site 311403001483 hypothetical protein; Provisional; Region: PRK12569 311403001484 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403001485 carboxyltransferase (CT) interaction site; other site 311403001486 biotinylation site [posttranslational modification]; other site 311403001487 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 311403001488 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403001489 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403001490 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 311403001491 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 311403001492 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 311403001493 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 311403001494 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403001495 DNA-binding site [nucleotide binding]; DNA binding site 311403001496 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403001497 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403001498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001499 Walker A/P-loop; other site 311403001500 ATP binding site [chemical binding]; other site 311403001501 Q-loop/lid; other site 311403001502 ABC transporter signature motif; other site 311403001503 Walker B; other site 311403001504 D-loop; other site 311403001505 H-loop/switch region; other site 311403001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001507 dimer interface [polypeptide binding]; other site 311403001508 conserved gate region; other site 311403001509 putative PBP binding loops; other site 311403001510 ABC-ATPase subunit interface; other site 311403001511 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403001512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001513 dimer interface [polypeptide binding]; other site 311403001514 conserved gate region; other site 311403001515 putative PBP binding loops; other site 311403001516 ABC-ATPase subunit interface; other site 311403001517 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403001518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403001519 NAD(P) binding site [chemical binding]; other site 311403001520 active site 311403001521 classical (c) SDRs; Region: SDR_c; cd05233 311403001522 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403001523 NAD(P) binding site [chemical binding]; other site 311403001524 active site 311403001525 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403001526 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403001527 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403001528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001529 Walker A/P-loop; other site 311403001530 ATP binding site [chemical binding]; other site 311403001531 Q-loop/lid; other site 311403001532 ABC transporter signature motif; other site 311403001533 Walker B; other site 311403001534 D-loop; other site 311403001535 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403001536 H-loop/switch region; other site 311403001537 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 311403001538 active site 311403001539 catalytic site [active] 311403001540 Zn binding site [ion binding]; other site 311403001541 tetramer interface [polypeptide binding]; other site 311403001542 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 311403001543 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 311403001544 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 311403001545 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 311403001546 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403001547 hypothetical protein; Provisional; Region: PRK06102 311403001548 Amidase; Region: Amidase; cl11426 311403001549 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 311403001550 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403001551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403001552 DNA binding residues [nucleotide binding] 311403001553 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 311403001554 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 311403001555 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 311403001556 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403001557 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403001558 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403001559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001560 Walker A/P-loop; other site 311403001561 ATP binding site [chemical binding]; other site 311403001562 Q-loop/lid; other site 311403001563 ABC transporter signature motif; other site 311403001564 Walker B; other site 311403001565 D-loop; other site 311403001566 H-loop/switch region; other site 311403001567 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403001568 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403001569 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403001570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001571 dimer interface [polypeptide binding]; other site 311403001572 conserved gate region; other site 311403001573 putative PBP binding loops; other site 311403001574 ABC-ATPase subunit interface; other site 311403001575 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403001576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001577 dimer interface [polypeptide binding]; other site 311403001578 conserved gate region; other site 311403001579 putative PBP binding loops; other site 311403001580 ABC-ATPase subunit interface; other site 311403001581 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403001582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001583 Walker A/P-loop; other site 311403001584 ATP binding site [chemical binding]; other site 311403001585 Q-loop/lid; other site 311403001586 ABC transporter signature motif; other site 311403001587 Walker B; other site 311403001588 D-loop; other site 311403001589 H-loop/switch region; other site 311403001590 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403001591 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403001592 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403001593 TM-ABC transporter signature motif; other site 311403001594 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 311403001595 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403001596 putative ligand binding site [chemical binding]; other site 311403001597 short chain dehydrogenase; Provisional; Region: PRK06841 311403001598 classical (c) SDRs; Region: SDR_c; cd05233 311403001599 NAD(P) binding site [chemical binding]; other site 311403001600 active site 311403001601 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 311403001602 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 311403001603 DAK2 domain; Region: Dak2; pfam02734 311403001604 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403001605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403001606 DNA binding residues [nucleotide binding] 311403001607 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403001608 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 311403001609 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 311403001610 DAK2 domain; Region: Dak2; cl03685 311403001611 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 311403001612 nucleophile elbow; other site 311403001613 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403001614 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403001615 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 311403001616 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 311403001617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403001618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403001619 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403001620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403001621 NAD(P) binding site [chemical binding]; other site 311403001622 active site 311403001623 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403001624 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 311403001625 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 311403001626 N-terminal domain interface [polypeptide binding]; other site 311403001627 dimer interface [polypeptide binding]; other site 311403001628 substrate binding pocket (H-site) [chemical binding]; other site 311403001629 Isochorismatase family; Region: Isochorismatase; pfam00857 311403001630 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 311403001631 catalytic triad [active] 311403001632 conserved cis-peptide bond; other site 311403001633 Uncharacterized conserved protein [Function unknown]; Region: COG1359 311403001634 short chain dehydrogenase; Provisional; Region: PRK06500 311403001635 classical (c) SDRs; Region: SDR_c; cd05233 311403001636 NAD(P) binding site [chemical binding]; other site 311403001637 active site 311403001638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403001639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001640 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 311403001641 putative effector binding pocket; other site 311403001642 putative dimerization interface [polypeptide binding]; other site 311403001643 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403001644 cyclase homology domain; Region: CHD; cd07302 311403001645 nucleotidyl binding site; other site 311403001646 metal binding site [ion binding]; metal-binding site 311403001647 dimer interface [polypeptide binding]; other site 311403001648 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 311403001649 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 311403001650 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 311403001651 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 311403001652 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 311403001653 Outer membrane efflux protein; Region: OEP; pfam02321 311403001654 Cytochrome C' Region: Cytochrom_C_2; pfam01322 311403001655 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 311403001656 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403001657 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 311403001658 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403001659 DXD motif; other site 311403001660 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 311403001661 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403001662 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 311403001663 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 311403001664 NAD binding site [chemical binding]; other site 311403001665 substrate binding site [chemical binding]; other site 311403001666 catalytic Zn binding site [ion binding]; other site 311403001667 tetramer interface [polypeptide binding]; other site 311403001668 structural Zn binding site [ion binding]; other site 311403001669 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403001670 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 311403001671 NAD(P) binding site [chemical binding]; other site 311403001672 catalytic residues [active] 311403001673 putative phosphoketolase; Provisional; Region: PRK05261 311403001674 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 311403001675 TPP-binding site; other site 311403001676 XFP C-terminal domain; Region: XFP_C; pfam09363 311403001677 acetate kinase; Provisional; Region: PRK07058 311403001678 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 311403001679 Ligand Binding Site [chemical binding]; other site 311403001680 osmolarity response regulator; Provisional; Region: ompR; PRK09468 311403001681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403001682 active site 311403001683 phosphorylation site [posttranslational modification] 311403001684 intermolecular recognition site; other site 311403001685 dimerization interface [polypeptide binding]; other site 311403001686 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403001687 DNA binding site [nucleotide binding] 311403001688 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 311403001689 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403001690 ligand binding site [chemical binding]; other site 311403001691 flexible hinge region; other site 311403001692 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 311403001693 putative switch regulator; other site 311403001694 non-specific DNA interactions [nucleotide binding]; other site 311403001695 DNA binding site [nucleotide binding] 311403001696 sequence specific DNA binding site [nucleotide binding]; other site 311403001697 putative cAMP binding site [chemical binding]; other site 311403001698 PAS domain; Region: PAS_9; pfam13426 311403001699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403001700 putative active site [active] 311403001701 heme pocket [chemical binding]; other site 311403001702 PAS domain S-box; Region: sensory_box; TIGR00229 311403001703 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403001704 putative active site [active] 311403001705 heme pocket [chemical binding]; other site 311403001706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403001707 dimer interface [polypeptide binding]; other site 311403001708 phosphorylation site [posttranslational modification] 311403001709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403001710 ATP binding site [chemical binding]; other site 311403001711 G-X-G motif; other site 311403001712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403001713 active site 311403001714 phosphorylation site [posttranslational modification] 311403001715 intermolecular recognition site; other site 311403001716 dimerization interface [polypeptide binding]; other site 311403001717 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 311403001718 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 311403001719 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 311403001720 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 311403001721 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 311403001722 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 311403001723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001724 Walker A/P-loop; other site 311403001725 ATP binding site [chemical binding]; other site 311403001726 Q-loop/lid; other site 311403001727 ABC transporter signature motif; other site 311403001728 Walker B; other site 311403001729 D-loop; other site 311403001730 H-loop/switch region; other site 311403001731 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 311403001732 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403001733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403001734 Walker A/P-loop; other site 311403001735 ATP binding site [chemical binding]; other site 311403001736 Q-loop/lid; other site 311403001737 ABC transporter signature motif; other site 311403001738 Walker B; other site 311403001739 D-loop; other site 311403001740 H-loop/switch region; other site 311403001741 Predicted transcriptional regulators [Transcription]; Region: COG1510 311403001742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403001743 dimerization interface [polypeptide binding]; other site 311403001744 putative DNA binding site [nucleotide binding]; other site 311403001745 putative Zn2+ binding site [ion binding]; other site 311403001746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 311403001747 BON domain; Region: BON; pfam04972 311403001748 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 311403001749 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 311403001750 FOG: CBS domain [General function prediction only]; Region: COG0517 311403001751 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 311403001752 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 311403001753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 311403001754 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 311403001755 Ligand Binding Site [chemical binding]; other site 311403001756 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 311403001757 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 311403001758 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 311403001759 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 311403001760 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 311403001761 dimer interface [polypeptide binding]; other site 311403001762 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 311403001763 anti sigma factor interaction site; other site 311403001764 regulatory phosphorylation site [posttranslational modification]; other site 311403001765 Cache domain; Region: Cache_1; pfam02743 311403001766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403001767 dimerization interface [polypeptide binding]; other site 311403001768 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 311403001769 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 311403001770 hypothetical protein; Provisional; Region: PRK08317 311403001771 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403001772 S-adenosylmethionine binding site [chemical binding]; other site 311403001773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403001774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403001775 metal binding site [ion binding]; metal-binding site 311403001776 active site 311403001777 I-site; other site 311403001778 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403001779 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403001780 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 311403001781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403001782 NAD binding site [chemical binding]; other site 311403001783 putative substrate binding site 2 [chemical binding]; other site 311403001784 putative substrate binding site 1 [chemical binding]; other site 311403001785 active site 311403001786 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 311403001787 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 311403001788 NAD binding site [chemical binding]; other site 311403001789 homodimer interface [polypeptide binding]; other site 311403001790 active site 311403001791 substrate binding site [chemical binding]; other site 311403001792 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 311403001793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 311403001794 active site 311403001795 Cellulose synthase-like protein; Region: PLN02893 311403001796 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 311403001797 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 311403001798 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 311403001799 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 311403001800 Protein of unknown function (DUF995); Region: DUF995; pfam06191 311403001801 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 311403001802 Protein of unknown function (DUF995); Region: DUF995; pfam06191 311403001803 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403001804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403001805 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403001806 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 311403001807 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 311403001808 SLBB domain; Region: SLBB; pfam10531 311403001809 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 311403001810 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 311403001811 active site 311403001812 catalytic residues [active] 311403001813 O-Antigen ligase; Region: Wzy_C; pfam04932 311403001814 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 311403001815 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403001816 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 311403001817 active site 311403001818 Bacterial sugar transferase; Region: Bac_transf; pfam02397 311403001819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403001820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403001821 DNA binding residues [nucleotide binding] 311403001822 dimerization interface [polypeptide binding]; other site 311403001823 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 311403001824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403001825 S-adenosylmethionine binding site [chemical binding]; other site 311403001826 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 311403001827 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 311403001828 active site 311403001829 dimer interface [polypeptide binding]; other site 311403001830 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 311403001831 Ligand Binding Site [chemical binding]; other site 311403001832 Molecular Tunnel; other site 311403001833 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 311403001834 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 311403001835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 311403001836 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 311403001837 acyl-activating enzyme (AAE) consensus motif; other site 311403001838 acyl-activating enzyme (AAE) consensus motif; other site 311403001839 putative AMP binding site [chemical binding]; other site 311403001840 putative active site [active] 311403001841 putative CoA binding site [chemical binding]; other site 311403001842 NAD synthetase; Reviewed; Region: nadE; PRK00876 311403001843 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 311403001844 homodimer interface [polypeptide binding]; other site 311403001845 NAD binding pocket [chemical binding]; other site 311403001846 ATP binding pocket [chemical binding]; other site 311403001847 Mg binding site [ion binding]; other site 311403001848 active-site loop [active] 311403001849 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 311403001850 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 311403001851 CHASE4 domain; Region: CHASE4; pfam05228 311403001852 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403001853 metal binding site [ion binding]; metal-binding site 311403001854 active site 311403001855 I-site; other site 311403001856 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403001857 Uncharacterized conserved protein [Function unknown]; Region: COG5649 311403001858 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 311403001859 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 311403001860 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 311403001861 putative catalytic residue [active] 311403001862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403001863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403001864 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 311403001865 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403001866 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 311403001867 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403001868 active site 311403001869 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 311403001870 dimer interface [polypeptide binding]; other site 311403001871 non-prolyl cis peptide bond; other site 311403001872 insertion regions; other site 311403001873 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403001874 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 311403001875 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403001876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001877 putative PBP binding loops; other site 311403001878 ABC-ATPase subunit interface; other site 311403001879 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403001880 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403001881 Walker A/P-loop; other site 311403001882 ATP binding site [chemical binding]; other site 311403001883 Q-loop/lid; other site 311403001884 ABC transporter signature motif; other site 311403001885 Walker B; other site 311403001886 D-loop; other site 311403001887 H-loop/switch region; other site 311403001888 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 311403001889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403001890 dimer interface [polypeptide binding]; other site 311403001891 phosphorylation site [posttranslational modification] 311403001892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403001893 ATP binding site [chemical binding]; other site 311403001894 Mg2+ binding site [ion binding]; other site 311403001895 G-X-G motif; other site 311403001896 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 311403001897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403001898 active site 311403001899 phosphorylation site [posttranslational modification] 311403001900 intermolecular recognition site; other site 311403001901 dimerization interface [polypeptide binding]; other site 311403001902 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403001903 Walker A motif; other site 311403001904 ATP binding site [chemical binding]; other site 311403001905 Walker B motif; other site 311403001906 arginine finger; other site 311403001907 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403001908 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403001909 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403001910 DNA binding site [nucleotide binding] 311403001911 domain linker motif; other site 311403001912 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 311403001913 putative ligand binding site [chemical binding]; other site 311403001914 putative dimerization interface [polypeptide binding]; other site 311403001915 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 311403001916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403001917 putative substrate translocation pore; other site 311403001918 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 311403001919 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 311403001920 putative ligand binding site [chemical binding]; other site 311403001921 putative NAD binding site [chemical binding]; other site 311403001922 catalytic site [active] 311403001923 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403001924 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403001925 inhibitor site; inhibition site 311403001926 active site 311403001927 dimer interface [polypeptide binding]; other site 311403001928 catalytic residue [active] 311403001929 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 311403001930 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403001931 putative NAD(P) binding site [chemical binding]; other site 311403001932 Cupin; Region: Cupin_6; pfam12852 311403001933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403001934 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403001935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403001936 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 311403001937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403001938 Coenzyme A binding pocket [chemical binding]; other site 311403001939 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 311403001940 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 311403001941 MOFRL family; Region: MOFRL; pfam05161 311403001942 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 311403001943 tartrate dehydrogenase; Region: TTC; TIGR02089 311403001944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403001945 D-galactonate transporter; Region: 2A0114; TIGR00893 311403001946 putative substrate translocation pore; other site 311403001947 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 311403001948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403001949 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 311403001950 dimerization interface [polypeptide binding]; other site 311403001951 substrate binding pocket [chemical binding]; other site 311403001952 RNA polymerase sigma factor; Reviewed; Region: PRK12527 311403001953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403001954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403001955 DNA binding residues [nucleotide binding] 311403001956 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 311403001957 FecR protein; Region: FecR; pfam04773 311403001958 Secretin and TonB N terminus short domain; Region: STN; smart00965 311403001959 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 311403001960 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 311403001961 N-terminal plug; other site 311403001962 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 311403001963 muropeptide transporter; Validated; Region: ampG; cl17669 311403001964 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 311403001965 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 311403001966 FAD binding pocket [chemical binding]; other site 311403001967 FAD binding motif [chemical binding]; other site 311403001968 phosphate binding motif [ion binding]; other site 311403001969 NAD binding pocket [chemical binding]; other site 311403001970 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949 311403001971 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403001972 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 311403001973 metal binding site [ion binding]; metal-binding site 311403001974 putative dimer interface [polypeptide binding]; other site 311403001975 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403001976 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 311403001977 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001979 dimer interface [polypeptide binding]; other site 311403001980 conserved gate region; other site 311403001981 putative PBP binding loops; other site 311403001982 ABC-ATPase subunit interface; other site 311403001983 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403001984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403001985 dimer interface [polypeptide binding]; other site 311403001986 conserved gate region; other site 311403001987 putative PBP binding loops; other site 311403001988 ABC-ATPase subunit interface; other site 311403001989 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403001990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403001991 Walker A/P-loop; other site 311403001992 ATP binding site [chemical binding]; other site 311403001993 Q-loop/lid; other site 311403001994 ABC transporter signature motif; other site 311403001995 Walker B; other site 311403001996 D-loop; other site 311403001997 H-loop/switch region; other site 311403001998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403001999 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002000 Walker A/P-loop; other site 311403002001 ATP binding site [chemical binding]; other site 311403002002 Q-loop/lid; other site 311403002003 ABC transporter signature motif; other site 311403002004 Walker B; other site 311403002005 D-loop; other site 311403002006 H-loop/switch region; other site 311403002007 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403002008 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 311403002009 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403002010 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 311403002011 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 311403002012 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 311403002013 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403002014 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 311403002015 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403002016 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403002017 Flavin binding site [chemical binding]; other site 311403002018 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403002019 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403002020 active site 311403002021 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 311403002022 dimer interface [polypeptide binding]; other site 311403002023 non-prolyl cis peptide bond; other site 311403002024 insertion regions; other site 311403002025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403002026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002027 dimer interface [polypeptide binding]; other site 311403002028 conserved gate region; other site 311403002029 putative PBP binding loops; other site 311403002030 ABC-ATPase subunit interface; other site 311403002031 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002033 dimer interface [polypeptide binding]; other site 311403002034 conserved gate region; other site 311403002035 putative PBP binding loops; other site 311403002036 ABC-ATPase subunit interface; other site 311403002037 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403002038 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002039 Walker A/P-loop; other site 311403002040 ATP binding site [chemical binding]; other site 311403002041 Q-loop/lid; other site 311403002042 ABC transporter signature motif; other site 311403002043 Walker B; other site 311403002044 D-loop; other site 311403002045 H-loop/switch region; other site 311403002046 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403002047 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 311403002048 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002049 Walker A/P-loop; other site 311403002050 ATP binding site [chemical binding]; other site 311403002051 Q-loop/lid; other site 311403002052 ABC transporter signature motif; other site 311403002053 Walker B; other site 311403002054 D-loop; other site 311403002055 H-loop/switch region; other site 311403002056 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403002057 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403002058 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403002059 active site 311403002060 catalytic tetrad [active] 311403002061 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403002062 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403002063 Flavin binding site [chemical binding]; other site 311403002064 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403002065 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 311403002066 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403002067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403002068 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403002069 dimerization interface [polypeptide binding]; other site 311403002070 substrate binding pocket [chemical binding]; other site 311403002071 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 311403002072 dimer interface [polypeptide binding]; other site 311403002073 FMN binding site [chemical binding]; other site 311403002074 NADPH bind site [chemical binding]; other site 311403002075 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403002076 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403002077 active site 311403002078 non-prolyl cis peptide bond; other site 311403002079 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403002080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403002081 active site 311403002082 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 311403002083 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403002084 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403002085 active site 311403002086 non-prolyl cis peptide bond; other site 311403002087 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403002088 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403002089 Flavin binding site [chemical binding]; other site 311403002090 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403002091 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403002092 Walker A/P-loop; other site 311403002093 ATP binding site [chemical binding]; other site 311403002094 Q-loop/lid; other site 311403002095 ABC transporter signature motif; other site 311403002096 Walker B; other site 311403002097 D-loop; other site 311403002098 H-loop/switch region; other site 311403002099 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 311403002100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403002101 substrate binding pocket [chemical binding]; other site 311403002102 membrane-bound complex binding site; other site 311403002103 hinge residues; other site 311403002104 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403002105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002106 dimer interface [polypeptide binding]; other site 311403002107 conserved gate region; other site 311403002108 putative PBP binding loops; other site 311403002109 ABC-ATPase subunit interface; other site 311403002110 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403002111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002112 dimer interface [polypeptide binding]; other site 311403002113 conserved gate region; other site 311403002114 putative PBP binding loops; other site 311403002115 ABC-ATPase subunit interface; other site 311403002116 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403002117 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 311403002118 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 311403002119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403002120 Coenzyme A binding pocket [chemical binding]; other site 311403002121 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403002122 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 311403002123 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403002124 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 311403002125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403002126 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403002127 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403002128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002129 dimer interface [polypeptide binding]; other site 311403002130 conserved gate region; other site 311403002131 putative PBP binding loops; other site 311403002132 ABC-ATPase subunit interface; other site 311403002133 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403002134 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002135 Walker A/P-loop; other site 311403002136 ATP binding site [chemical binding]; other site 311403002137 Q-loop/lid; other site 311403002138 ABC transporter signature motif; other site 311403002139 Walker B; other site 311403002140 D-loop; other site 311403002141 H-loop/switch region; other site 311403002142 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403002143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002144 Walker A/P-loop; other site 311403002145 ATP binding site [chemical binding]; other site 311403002146 Q-loop/lid; other site 311403002147 ABC transporter signature motif; other site 311403002148 Walker B; other site 311403002149 D-loop; other site 311403002150 H-loop/switch region; other site 311403002151 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403002152 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403002153 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403002154 active site 311403002155 non-prolyl cis peptide bond; other site 311403002156 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403002157 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403002158 active site 311403002159 non-prolyl cis peptide bond; other site 311403002160 Spore Coat Protein U domain; Region: SCPU; pfam05229 311403002161 Spore Coat Protein U domain; Region: SCPU; cl02253 311403002162 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 311403002163 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 311403002164 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 311403002165 PapC C-terminal domain; Region: PapC_C; pfam13953 311403002166 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 311403002167 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 311403002168 Uncharacterized secreted protein [Function unknown]; Region: COG5430 311403002169 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403002170 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403002171 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 311403002172 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403002173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403002174 Coenzyme A binding pocket [chemical binding]; other site 311403002175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403002176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002177 dimer interface [polypeptide binding]; other site 311403002178 conserved gate region; other site 311403002179 putative PBP binding loops; other site 311403002180 ABC-ATPase subunit interface; other site 311403002181 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403002182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002183 dimer interface [polypeptide binding]; other site 311403002184 conserved gate region; other site 311403002185 putative PBP binding loops; other site 311403002186 ABC-ATPase subunit interface; other site 311403002187 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403002188 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403002189 Walker A/P-loop; other site 311403002190 ATP binding site [chemical binding]; other site 311403002191 Q-loop/lid; other site 311403002192 ABC transporter signature motif; other site 311403002193 Walker B; other site 311403002194 D-loop; other site 311403002195 H-loop/switch region; other site 311403002196 TOBE domain; Region: TOBE_2; pfam08402 311403002197 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403002198 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403002199 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 311403002200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403002201 DNA-binding site [nucleotide binding]; DNA binding site 311403002202 UTRA domain; Region: UTRA; pfam07702 311403002203 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 311403002204 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 311403002205 active site 311403002206 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403002207 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 311403002208 active site pocket [active] 311403002209 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403002210 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002211 Walker A/P-loop; other site 311403002212 ATP binding site [chemical binding]; other site 311403002213 Q-loop/lid; other site 311403002214 ABC transporter signature motif; other site 311403002215 Walker B; other site 311403002216 D-loop; other site 311403002217 H-loop/switch region; other site 311403002218 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403002219 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002220 Walker A/P-loop; other site 311403002221 ATP binding site [chemical binding]; other site 311403002222 Q-loop/lid; other site 311403002223 ABC transporter signature motif; other site 311403002224 Walker B; other site 311403002225 D-loop; other site 311403002226 H-loop/switch region; other site 311403002227 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403002228 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403002229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403002230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002231 dimer interface [polypeptide binding]; other site 311403002232 conserved gate region; other site 311403002233 putative PBP binding loops; other site 311403002234 ABC-ATPase subunit interface; other site 311403002235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403002236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002237 dimer interface [polypeptide binding]; other site 311403002238 conserved gate region; other site 311403002239 putative PBP binding loops; other site 311403002240 ABC-ATPase subunit interface; other site 311403002241 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 311403002242 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 311403002243 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403002244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403002245 DNA-binding site [nucleotide binding]; DNA binding site 311403002246 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 311403002247 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403002248 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403002249 inhibitor site; inhibition site 311403002250 active site 311403002251 dimer interface [polypeptide binding]; other site 311403002252 catalytic residue [active] 311403002253 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403002254 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 311403002255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403002256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002257 dimer interface [polypeptide binding]; other site 311403002258 conserved gate region; other site 311403002259 putative PBP binding loops; other site 311403002260 ABC-ATPase subunit interface; other site 311403002261 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403002262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002263 dimer interface [polypeptide binding]; other site 311403002264 conserved gate region; other site 311403002265 putative PBP binding loops; other site 311403002266 ABC-ATPase subunit interface; other site 311403002267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002268 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 311403002269 Walker A/P-loop; other site 311403002270 ATP binding site [chemical binding]; other site 311403002271 Q-loop/lid; other site 311403002272 ABC transporter signature motif; other site 311403002273 Walker B; other site 311403002274 D-loop; other site 311403002275 H-loop/switch region; other site 311403002276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403002277 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403002278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002279 Walker A/P-loop; other site 311403002280 ATP binding site [chemical binding]; other site 311403002281 Q-loop/lid; other site 311403002282 ABC transporter signature motif; other site 311403002283 Walker B; other site 311403002284 D-loop; other site 311403002285 H-loop/switch region; other site 311403002286 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403002287 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 311403002288 active site 311403002289 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 311403002290 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 311403002291 putative active site [active] 311403002292 catalytic site [active] 311403002293 putative metal binding site [ion binding]; other site 311403002294 oligomer interface [polypeptide binding]; other site 311403002295 MarR family; Region: MarR_2; pfam12802 311403002296 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403002297 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403002298 nucleotide binding site [chemical binding]; other site 311403002299 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 311403002300 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 311403002301 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 311403002302 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 311403002303 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403002304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403002305 metal binding site [ion binding]; metal-binding site 311403002306 active site 311403002307 I-site; other site 311403002308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403002309 EF-hand domain pair; Region: EF_hand_5; pfam13499 311403002310 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 311403002311 EF-hand domain pair; Region: EF_hand_5; pfam13499 311403002312 Ca2+ binding site [ion binding]; other site 311403002313 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 311403002314 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 311403002315 putative ligand binding residues [chemical binding]; other site 311403002316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403002317 S-adenosylmethionine binding site [chemical binding]; other site 311403002318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 311403002319 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403002320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403002321 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 311403002322 HAMP domain; Region: HAMP; pfam00672 311403002323 dimerization interface [polypeptide binding]; other site 311403002324 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 311403002325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403002326 dimer interface [polypeptide binding]; other site 311403002327 putative CheW interface [polypeptide binding]; other site 311403002328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403002329 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403002330 TM-ABC transporter signature motif; other site 311403002331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403002332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403002333 TM-ABC transporter signature motif; other site 311403002334 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403002335 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403002336 Walker A/P-loop; other site 311403002337 ATP binding site [chemical binding]; other site 311403002338 Q-loop/lid; other site 311403002339 ABC transporter signature motif; other site 311403002340 Walker B; other site 311403002341 D-loop; other site 311403002342 H-loop/switch region; other site 311403002343 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403002344 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 311403002345 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403002346 putative ligand binding site [chemical binding]; other site 311403002347 Protein of unknown function (DUF982); Region: DUF982; pfam06169 311403002348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403002349 metabolite-proton symporter; Region: 2A0106; TIGR00883 311403002350 putative substrate translocation pore; other site 311403002351 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 311403002352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403002353 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 311403002354 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 311403002355 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 311403002356 shikimate binding site; other site 311403002357 NAD(P) binding site [chemical binding]; other site 311403002358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 311403002359 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403002360 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403002361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403002362 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403002363 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403002364 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403002365 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403002366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403002367 non-specific DNA binding site [nucleotide binding]; other site 311403002368 salt bridge; other site 311403002369 sequence-specific DNA binding site [nucleotide binding]; other site 311403002370 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403002371 Integrase core domain; Region: rve; pfam00665 311403002372 DDE domain; Region: DDE_Tnp_IS240; pfam13610 311403002373 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 311403002374 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 311403002375 active site 311403002376 catalytic site [active] 311403002377 substrate binding site [chemical binding]; other site 311403002378 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 311403002379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403002380 dimerization interface [polypeptide binding]; other site 311403002381 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 311403002382 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403002383 dimer interface [polypeptide binding]; other site 311403002384 putative CheW interface [polypeptide binding]; other site 311403002385 Fic family protein [Function unknown]; Region: COG3177 311403002386 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 311403002387 Fic/DOC family; Region: Fic; pfam02661 311403002388 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403002389 active site 311403002390 DNA binding site [nucleotide binding] 311403002391 Int/Topo IB signature motif; other site 311403002392 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 311403002393 putative active site [active] 311403002394 TniQ; Region: TniQ; pfam06527 311403002395 Bacterial TniB protein; Region: TniB; pfam05621 311403002396 AAA domain; Region: AAA_22; pfam13401 311403002397 Integrase core domain; Region: rve; pfam00665 311403002398 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 311403002399 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 311403002400 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 311403002401 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 311403002402 ligand binding site [chemical binding]; other site 311403002403 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 311403002404 Mechanosensitive ion channel; Region: MS_channel; pfam00924 311403002405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403002406 TPR motif; other site 311403002407 binding surface 311403002408 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 311403002409 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 311403002410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403002411 motif II; other site 311403002412 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 311403002413 Uncharacterized conserved protein [Function unknown]; Region: COG1262 311403002414 Oxygen tolerance; Region: BatD; pfam13584 311403002415 von Willebrand factor type A domain; Region: VWA_2; pfam13519 311403002416 metal ion-dependent adhesion site (MIDAS); other site 311403002417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403002418 binding surface 311403002419 TPR motif; other site 311403002420 TPR repeat; Region: TPR_11; pfam13414 311403002421 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 311403002422 metal ion-dependent adhesion site (MIDAS); other site 311403002423 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 311403002424 Protein of unknown function DUF58; Region: DUF58; pfam01882 311403002425 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 311403002426 metal ion-dependent adhesion site (MIDAS); other site 311403002427 MoxR-like ATPases [General function prediction only]; Region: COG0714 311403002428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403002429 Walker A motif; other site 311403002430 ATP binding site [chemical binding]; other site 311403002431 Walker B motif; other site 311403002432 arginine finger; other site 311403002433 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 311403002434 Sulfatase; Region: Sulfatase; pfam00884 311403002435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 311403002436 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 311403002437 HTH DNA binding domain; Region: HTH_13; pfam11972 311403002438 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 311403002439 Cytochrome P450; Region: p450; cl12078 311403002440 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 311403002441 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 311403002442 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403002443 catalytic residue [active] 311403002444 Cupin-like domain; Region: Cupin_8; pfam13621 311403002445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403002446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403002447 non-specific DNA binding site [nucleotide binding]; other site 311403002448 salt bridge; other site 311403002449 sequence-specific DNA binding site [nucleotide binding]; other site 311403002450 AAA ATPase domain; Region: AAA_16; pfam13191 311403002451 RES domain; Region: RES; smart00953 311403002452 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 311403002453 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 311403002454 PhoH-like protein; Region: PhoH; cl17668 311403002455 Family description; Region: UvrD_C_2; pfam13538 311403002456 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 311403002457 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 311403002458 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 311403002459 active site 311403002460 metal binding site [ion binding]; metal-binding site 311403002461 Protein of unknown function (DUF867); Region: DUF867; pfam05908 311403002462 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 311403002463 Ligand Binding Site [chemical binding]; other site 311403002464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403002465 sequence-specific DNA binding site [nucleotide binding]; other site 311403002466 salt bridge; other site 311403002467 Domain of unknown function (DUF955); Region: DUF955; cl01076 311403002468 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 311403002469 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 311403002470 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 311403002471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403002472 active site 311403002473 phosphorylation site [posttranslational modification] 311403002474 intermolecular recognition site; other site 311403002475 dimerization interface [polypeptide binding]; other site 311403002476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403002477 DNA binding site [nucleotide binding] 311403002478 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 311403002479 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 311403002480 Walker A/P-loop; other site 311403002481 ATP binding site [chemical binding]; other site 311403002482 Q-loop/lid; other site 311403002483 ABC transporter signature motif; other site 311403002484 Walker B; other site 311403002485 D-loop; other site 311403002486 H-loop/switch region; other site 311403002487 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 311403002488 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 311403002489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002490 dimer interface [polypeptide binding]; other site 311403002491 conserved gate region; other site 311403002492 ABC-ATPase subunit interface; other site 311403002493 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 311403002494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002495 dimer interface [polypeptide binding]; other site 311403002496 conserved gate region; other site 311403002497 ABC-ATPase subunit interface; other site 311403002498 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403002499 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403002500 Metal-binding active site; metal-binding site 311403002501 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 311403002502 active site 311403002503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403002504 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 311403002505 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 311403002506 tetramer interface [polypeptide binding]; other site 311403002507 active site 311403002508 Mg2+/Mn2+ binding site [ion binding]; other site 311403002509 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 311403002510 PQQ-like domain; Region: PQQ_2; pfam13360 311403002511 Trp docking motif [polypeptide binding]; other site 311403002512 active site 311403002513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 311403002514 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 311403002515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403002516 catalytic residue [active] 311403002517 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403002518 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 311403002519 PYR/PP interface [polypeptide binding]; other site 311403002520 dimer interface [polypeptide binding]; other site 311403002521 TPP binding site [chemical binding]; other site 311403002522 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 311403002523 TPP-binding site; other site 311403002524 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 311403002525 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 311403002526 PA/protease or protease-like domain interface [polypeptide binding]; other site 311403002527 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 311403002528 metal binding site [ion binding]; metal-binding site 311403002529 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 311403002530 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403002531 inhibitor-cofactor binding pocket; inhibition site 311403002532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403002533 catalytic residue [active] 311403002534 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 311403002535 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403002536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 311403002537 binding surface 311403002538 TPR motif; other site 311403002539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403002540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403002541 active site 311403002542 metal binding site [ion binding]; metal-binding site 311403002543 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 311403002544 active site 311403002545 metal-binding site 311403002546 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 311403002547 LicD family; Region: LicD; pfam04991 311403002548 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 311403002549 putative active site pocket [active] 311403002550 dimerization interface [polypeptide binding]; other site 311403002551 putative catalytic residue [active] 311403002552 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 311403002553 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 311403002554 G1 box; other site 311403002555 putative GEF interaction site [polypeptide binding]; other site 311403002556 GTP/Mg2+ binding site [chemical binding]; other site 311403002557 Switch I region; other site 311403002558 G2 box; other site 311403002559 G3 box; other site 311403002560 Switch II region; other site 311403002561 G4 box; other site 311403002562 G5 box; other site 311403002563 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 311403002564 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 311403002565 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 311403002566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403002567 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403002568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403002569 S-adenosylmethionine binding site [chemical binding]; other site 311403002570 mobile mystery protein B; Region: mob_myst_B; TIGR02613 311403002571 Fic/DOC family; Region: Fic; pfam02661 311403002572 mobile mystery protein A; Region: mob_myst_A; TIGR02612 311403002573 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403002574 non-specific DNA binding site [nucleotide binding]; other site 311403002575 salt bridge; other site 311403002576 sequence-specific DNA binding site [nucleotide binding]; other site 311403002577 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 311403002578 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 311403002579 putative active site [active] 311403002580 putative NTP binding site [chemical binding]; other site 311403002581 putative nucleic acid binding site [nucleotide binding]; other site 311403002582 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 311403002583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403002584 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403002585 active site 311403002586 catalytic tetrad [active] 311403002587 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 311403002588 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 311403002589 Esterase/lipase [General function prediction only]; Region: COG1647 311403002590 short chain dehydrogenase; Provisional; Region: PRK08263 311403002591 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 311403002592 NADP binding site [chemical binding]; other site 311403002593 active site 311403002594 steroid binding site; other site 311403002595 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403002596 cyclase homology domain; Region: CHD; cd07302 311403002597 nucleotidyl binding site; other site 311403002598 metal binding site [ion binding]; metal-binding site 311403002599 dimer interface [polypeptide binding]; other site 311403002600 Predicted integral membrane protein [Function unknown]; Region: COG5616 311403002601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403002602 TPR motif; other site 311403002603 binding surface 311403002604 TPR repeat; Region: TPR_11; pfam13414 311403002605 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 311403002606 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 311403002607 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 311403002608 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 311403002609 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 311403002610 Autotransporter beta-domain; Region: Autotransporter; smart00869 311403002611 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 311403002612 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 311403002613 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 311403002614 putative molybdopterin cofactor binding site [chemical binding]; other site 311403002615 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 311403002616 putative molybdopterin cofactor binding site; other site 311403002617 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 311403002618 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 311403002619 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 311403002620 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 311403002621 Cation efflux family; Region: Cation_efflux; pfam01545 311403002622 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 311403002623 heat shock protein GrpE; Provisional; Region: PRK14141 311403002624 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 311403002625 dimer interface [polypeptide binding]; other site 311403002626 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 311403002627 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 311403002628 Mechanosensitive ion channel; Region: MS_channel; pfam00924 311403002629 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 311403002630 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 311403002631 dimer interface [polypeptide binding]; other site 311403002632 putative functional site; other site 311403002633 putative MPT binding site; other site 311403002634 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 311403002635 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 311403002636 nucleotide binding site [chemical binding]; other site 311403002637 NEF interaction site [polypeptide binding]; other site 311403002638 SBD interface [polypeptide binding]; other site 311403002639 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 311403002640 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 311403002641 HSP70 interaction site [polypeptide binding]; other site 311403002642 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 311403002643 substrate binding site [polypeptide binding]; other site 311403002644 dimer interface [polypeptide binding]; other site 311403002645 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 311403002646 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 311403002647 DNA binding residues [nucleotide binding] 311403002648 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 311403002649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403002650 active site 311403002651 phosphorylation site [posttranslational modification] 311403002652 intermolecular recognition site; other site 311403002653 dimerization interface [polypeptide binding]; other site 311403002654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403002655 Walker A motif; other site 311403002656 ATP binding site [chemical binding]; other site 311403002657 Walker B motif; other site 311403002658 arginine finger; other site 311403002659 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403002660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403002661 HAMP domain; Region: HAMP; pfam00672 311403002662 dimerization interface [polypeptide binding]; other site 311403002663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403002664 dimer interface [polypeptide binding]; other site 311403002665 phosphorylation site [posttranslational modification] 311403002666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403002667 ATP binding site [chemical binding]; other site 311403002668 Mg2+ binding site [ion binding]; other site 311403002669 G-X-G motif; other site 311403002670 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 311403002671 Clp amino terminal domain; Region: Clp_N; pfam02861 311403002672 Clp amino terminal domain; Region: Clp_N; pfam02861 311403002673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403002674 Walker A motif; other site 311403002675 ATP binding site [chemical binding]; other site 311403002676 Walker B motif; other site 311403002677 arginine finger; other site 311403002678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403002679 Walker A motif; other site 311403002680 ATP binding site [chemical binding]; other site 311403002681 Walker B motif; other site 311403002682 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 311403002683 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 311403002684 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 311403002685 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 311403002686 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 311403002687 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 311403002688 active site 311403002689 catalytic residues [active] 311403002690 metal binding site [ion binding]; metal-binding site 311403002691 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 311403002692 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403002693 PYR/PP interface [polypeptide binding]; other site 311403002694 dimer interface [polypeptide binding]; other site 311403002695 TPP binding site [chemical binding]; other site 311403002696 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 311403002697 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 311403002698 TPP-binding site [chemical binding]; other site 311403002699 MEKHLA domain; Region: MEKHLA; pfam08670 311403002700 BON domain; Region: BON; cl02771 311403002701 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403002702 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 311403002703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403002704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002705 dimer interface [polypeptide binding]; other site 311403002706 conserved gate region; other site 311403002707 putative PBP binding loops; other site 311403002708 ABC-ATPase subunit interface; other site 311403002709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403002710 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403002711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002712 dimer interface [polypeptide binding]; other site 311403002713 conserved gate region; other site 311403002714 putative PBP binding loops; other site 311403002715 ABC-ATPase subunit interface; other site 311403002716 Predicted amidohydrolase [General function prediction only]; Region: COG3964 311403002717 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 311403002718 active site 311403002719 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 311403002720 homotrimer interaction site [polypeptide binding]; other site 311403002721 putative active site [active] 311403002722 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 311403002723 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403002724 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403002725 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 311403002726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403002727 catalytic residue [active] 311403002728 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403002729 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002730 Walker A/P-loop; other site 311403002731 ATP binding site [chemical binding]; other site 311403002732 Q-loop/lid; other site 311403002733 ABC transporter signature motif; other site 311403002734 Walker B; other site 311403002735 D-loop; other site 311403002736 H-loop/switch region; other site 311403002737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403002738 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002739 Walker A/P-loop; other site 311403002740 ATP binding site [chemical binding]; other site 311403002741 Q-loop/lid; other site 311403002742 ABC transporter signature motif; other site 311403002743 Walker B; other site 311403002744 D-loop; other site 311403002745 H-loop/switch region; other site 311403002746 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403002747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002748 dimer interface [polypeptide binding]; other site 311403002749 conserved gate region; other site 311403002750 ABC-ATPase subunit interface; other site 311403002751 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403002752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002753 dimer interface [polypeptide binding]; other site 311403002754 conserved gate region; other site 311403002755 putative PBP binding loops; other site 311403002756 ABC-ATPase subunit interface; other site 311403002757 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403002758 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403002759 substrate binding pocket [chemical binding]; other site 311403002760 membrane-bound complex binding site; other site 311403002761 hinge residues; other site 311403002762 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403002763 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403002764 Walker A/P-loop; other site 311403002765 ATP binding site [chemical binding]; other site 311403002766 Q-loop/lid; other site 311403002767 ABC transporter signature motif; other site 311403002768 Walker B; other site 311403002769 D-loop; other site 311403002770 H-loop/switch region; other site 311403002771 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 311403002772 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 311403002773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403002774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403002775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403002776 dimerization interface [polypeptide binding]; other site 311403002777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 311403002778 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 311403002779 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 311403002780 agmatinase; Region: agmatinase; TIGR01230 311403002781 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 311403002782 oligomer interface [polypeptide binding]; other site 311403002783 active site 311403002784 Mn binding site [ion binding]; other site 311403002785 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403002786 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403002787 Walker A/P-loop; other site 311403002788 ATP binding site [chemical binding]; other site 311403002789 Q-loop/lid; other site 311403002790 ABC transporter signature motif; other site 311403002791 Walker B; other site 311403002792 D-loop; other site 311403002793 H-loop/switch region; other site 311403002794 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002796 dimer interface [polypeptide binding]; other site 311403002797 conserved gate region; other site 311403002798 putative PBP binding loops; other site 311403002799 ABC-ATPase subunit interface; other site 311403002800 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403002801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002802 ABC-ATPase subunit interface; other site 311403002803 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403002804 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403002805 substrate binding pocket [chemical binding]; other site 311403002806 membrane-bound complex binding site; other site 311403002807 hinge residues; other site 311403002808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403002809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403002810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403002811 dimerization interface [polypeptide binding]; other site 311403002812 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 311403002813 putative active site [active] 311403002814 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 311403002815 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 311403002816 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 311403002817 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403002818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403002819 DNA-binding site [nucleotide binding]; DNA binding site 311403002820 FCD domain; Region: FCD; pfam07729 311403002821 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 311403002822 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 311403002823 ligand binding site [chemical binding]; other site 311403002824 NAD binding site [chemical binding]; other site 311403002825 dimerization interface [polypeptide binding]; other site 311403002826 catalytic site [active] 311403002827 allantoate amidohydrolase; Reviewed; Region: PRK12890 311403002828 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 311403002829 active site 311403002830 metal binding site [ion binding]; metal-binding site 311403002831 dimer interface [polypeptide binding]; other site 311403002832 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403002833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403002834 DNA-binding site [nucleotide binding]; DNA binding site 311403002835 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 311403002836 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403002837 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403002838 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 311403002839 active site 311403002840 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403002841 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403002842 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 311403002843 active site 311403002844 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 311403002845 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 311403002846 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403002847 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403002848 Walker A/P-loop; other site 311403002849 ATP binding site [chemical binding]; other site 311403002850 Q-loop/lid; other site 311403002851 ABC transporter signature motif; other site 311403002852 Walker B; other site 311403002853 D-loop; other site 311403002854 H-loop/switch region; other site 311403002855 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403002856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002857 dimer interface [polypeptide binding]; other site 311403002858 conserved gate region; other site 311403002859 putative PBP binding loops; other site 311403002860 ABC-ATPase subunit interface; other site 311403002861 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403002862 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403002863 substrate binding pocket [chemical binding]; other site 311403002864 membrane-bound complex binding site; other site 311403002865 hinge residues; other site 311403002866 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 311403002867 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 311403002868 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 311403002869 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 311403002870 catalytic residues [active] 311403002871 catalytic nucleophile [active] 311403002872 Presynaptic Site I dimer interface [polypeptide binding]; other site 311403002873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 311403002874 Synaptic Flat tetramer interface [polypeptide binding]; other site 311403002875 Synaptic Site I dimer interface [polypeptide binding]; other site 311403002876 DNA binding site [nucleotide binding] 311403002877 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 311403002878 DNA-binding interface [nucleotide binding]; DNA binding site 311403002879 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 311403002880 trimer interface [polypeptide binding]; other site 311403002881 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 311403002882 trimer interface [polypeptide binding]; other site 311403002883 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 311403002884 trimer interface [polypeptide binding]; other site 311403002885 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 311403002886 trimer interface [polypeptide binding]; other site 311403002887 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 311403002888 trimer interface [polypeptide binding]; other site 311403002889 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 311403002890 trimer interface [polypeptide binding]; other site 311403002891 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 311403002892 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 311403002893 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 311403002894 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 311403002895 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403002896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403002897 S-adenosylmethionine binding site [chemical binding]; other site 311403002898 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 311403002899 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 311403002900 Predicted peptidase [General function prediction only]; Region: COG4099 311403002901 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 311403002902 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 311403002903 catalytic residues [active] 311403002904 catalytic nucleophile [active] 311403002905 Presynaptic Site I dimer interface [polypeptide binding]; other site 311403002906 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 311403002907 Synaptic Flat tetramer interface [polypeptide binding]; other site 311403002908 Synaptic Site I dimer interface [polypeptide binding]; other site 311403002909 DNA binding site [nucleotide binding] 311403002910 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 311403002911 DNA-binding interface [nucleotide binding]; DNA binding site 311403002912 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 311403002913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403002914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403002915 dimerization interface [polypeptide binding]; other site 311403002916 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403002917 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403002918 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403002919 putative effector binding pocket; other site 311403002920 dimerization interface [polypeptide binding]; other site 311403002921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403002922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403002923 putative substrate translocation pore; other site 311403002924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403002925 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403002926 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403002927 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403002928 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002929 Walker A/P-loop; other site 311403002930 ATP binding site [chemical binding]; other site 311403002931 Q-loop/lid; other site 311403002932 ABC transporter signature motif; other site 311403002933 Walker B; other site 311403002934 D-loop; other site 311403002935 H-loop/switch region; other site 311403002936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002937 Walker A/P-loop; other site 311403002938 ATP binding site [chemical binding]; other site 311403002939 Q-loop/lid; other site 311403002940 ABC transporter signature motif; other site 311403002941 Walker B; other site 311403002942 D-loop; other site 311403002943 H-loop/switch region; other site 311403002944 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403002945 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403002946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002947 dimer interface [polypeptide binding]; other site 311403002948 conserved gate region; other site 311403002949 putative PBP binding loops; other site 311403002950 ABC-ATPase subunit interface; other site 311403002951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403002953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403002954 dimer interface [polypeptide binding]; other site 311403002955 conserved gate region; other site 311403002956 putative PBP binding loops; other site 311403002957 ABC-ATPase subunit interface; other site 311403002958 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403002959 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 311403002960 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 311403002961 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 311403002962 molybdopterin cofactor binding site [chemical binding]; other site 311403002963 substrate binding site [chemical binding]; other site 311403002964 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 311403002965 molybdopterin cofactor binding site; other site 311403002966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403002967 active site 311403002968 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 311403002969 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403002970 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 311403002971 Walker A/P-loop; other site 311403002972 ATP binding site [chemical binding]; other site 311403002973 Q-loop/lid; other site 311403002974 ABC transporter signature motif; other site 311403002975 Walker B; other site 311403002976 D-loop; other site 311403002977 H-loop/switch region; other site 311403002978 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 311403002979 Walker A/P-loop; other site 311403002980 ATP binding site [chemical binding]; other site 311403002981 Q-loop/lid; other site 311403002982 ABC transporter signature motif; other site 311403002983 Walker B; other site 311403002984 D-loop; other site 311403002985 H-loop/switch region; other site 311403002986 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403002987 active site 311403002988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403002989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403002990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403002991 dimerization interface [polypeptide binding]; other site 311403002992 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 311403002993 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403002994 Walker A/P-loop; other site 311403002995 ATP binding site [chemical binding]; other site 311403002996 Q-loop/lid; other site 311403002997 ABC transporter signature motif; other site 311403002998 Walker B; other site 311403002999 D-loop; other site 311403003000 H-loop/switch region; other site 311403003001 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403003002 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403003003 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403003004 Walker A/P-loop; other site 311403003005 ATP binding site [chemical binding]; other site 311403003006 Q-loop/lid; other site 311403003007 ABC transporter signature motif; other site 311403003008 Walker B; other site 311403003009 D-loop; other site 311403003010 H-loop/switch region; other site 311403003011 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403003012 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151 311403003013 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403003014 active site 311403003015 cytosine deaminase; Provisional; Region: PRK05985 311403003016 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 311403003017 active site 311403003018 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403003019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003020 dimer interface [polypeptide binding]; other site 311403003021 conserved gate region; other site 311403003022 putative PBP binding loops; other site 311403003023 ABC-ATPase subunit interface; other site 311403003024 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403003025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003026 dimer interface [polypeptide binding]; other site 311403003027 conserved gate region; other site 311403003028 putative PBP binding loops; other site 311403003029 ABC-ATPase subunit interface; other site 311403003030 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403003031 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 311403003032 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403003033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403003034 DNA-binding site [nucleotide binding]; DNA binding site 311403003035 FCD domain; Region: FCD; pfam07729 311403003036 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 311403003037 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 311403003038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 311403003039 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 311403003040 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 311403003041 FAD binding pocket [chemical binding]; other site 311403003042 FAD binding motif [chemical binding]; other site 311403003043 phosphate binding motif [ion binding]; other site 311403003044 NAD binding pocket [chemical binding]; other site 311403003045 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 311403003046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 311403003047 N-terminal plug; other site 311403003048 ligand-binding site [chemical binding]; other site 311403003049 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403003050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403003051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403003052 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 311403003053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403003054 putative substrate translocation pore; other site 311403003055 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 311403003056 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 311403003057 NAD binding site [chemical binding]; other site 311403003058 catalytic Zn binding site [ion binding]; other site 311403003059 structural Zn binding site [ion binding]; other site 311403003060 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403003061 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403003062 Walker A/P-loop; other site 311403003063 ATP binding site [chemical binding]; other site 311403003064 Q-loop/lid; other site 311403003065 ABC transporter signature motif; other site 311403003066 Walker B; other site 311403003067 D-loop; other site 311403003068 H-loop/switch region; other site 311403003069 TOBE domain; Region: TOBE_2; pfam08402 311403003070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403003071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003072 ABC-ATPase subunit interface; other site 311403003073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003074 dimer interface [polypeptide binding]; other site 311403003075 conserved gate region; other site 311403003076 putative PBP binding loops; other site 311403003077 ABC-ATPase subunit interface; other site 311403003078 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403003079 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403003080 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 311403003081 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 311403003082 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403003083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403003084 DNA binding site [nucleotide binding] 311403003085 domain linker motif; other site 311403003086 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403003087 dimerization interface [polypeptide binding]; other site 311403003088 ligand binding site [chemical binding]; other site 311403003089 short chain dehydrogenase; Provisional; Region: PRK06523 311403003090 classical (c) SDRs; Region: SDR_c; cd05233 311403003091 NAD(P) binding site [chemical binding]; other site 311403003092 active site 311403003093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 311403003094 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 311403003095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403003096 DNA-binding site [nucleotide binding]; DNA binding site 311403003097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403003098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403003099 homodimer interface [polypeptide binding]; other site 311403003100 catalytic residue [active] 311403003101 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 311403003102 Predicted amidohydrolase [General function prediction only]; Region: COG0388 311403003103 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 311403003104 putative active site [active] 311403003105 catalytic triad [active] 311403003106 putative dimer interface [polypeptide binding]; other site 311403003107 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 311403003108 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403003109 putative N-acetyltransferase, MSMEG_0567 N-terminal domain family; Region: MSMEG_0567_GNAT; TIGR04045 311403003110 Coenzyme A binding pocket [chemical binding]; other site 311403003111 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 311403003112 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 311403003113 dimerization interface [polypeptide binding]; other site 311403003114 putative ATP binding site [chemical binding]; other site 311403003115 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 311403003116 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 311403003117 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 311403003118 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 311403003119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403003120 probable biosynthetic protein, Pnap_2097 family; Region: biosn_Pnap_2097; TIGR04099 311403003121 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403003122 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403003123 Walker A/P-loop; other site 311403003124 ATP binding site [chemical binding]; other site 311403003125 Q-loop/lid; other site 311403003126 ABC transporter signature motif; other site 311403003127 Walker B; other site 311403003128 D-loop; other site 311403003129 H-loop/switch region; other site 311403003130 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003132 dimer interface [polypeptide binding]; other site 311403003133 conserved gate region; other site 311403003134 putative PBP binding loops; other site 311403003135 ABC-ATPase subunit interface; other site 311403003136 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403003137 NMT1-like family; Region: NMT1_2; pfam13379 311403003138 substrate binding pocket [chemical binding]; other site 311403003139 membrane-bound complex binding site; other site 311403003140 hinge residues; other site 311403003141 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 311403003142 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 311403003143 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 311403003144 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 311403003145 Sulfate transporter family; Region: Sulfate_transp; pfam00916 311403003146 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 311403003147 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 311403003148 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 311403003149 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403003150 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 311403003151 ligand binding site [chemical binding]; other site 311403003152 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403003153 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403003154 TM-ABC transporter signature motif; other site 311403003155 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403003156 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403003157 TM-ABC transporter signature motif; other site 311403003158 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403003159 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403003160 Walker A/P-loop; other site 311403003161 ATP binding site [chemical binding]; other site 311403003162 Q-loop/lid; other site 311403003163 ABC transporter signature motif; other site 311403003164 Walker B; other site 311403003165 D-loop; other site 311403003166 H-loop/switch region; other site 311403003167 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403003168 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403003169 Walker A/P-loop; other site 311403003170 ATP binding site [chemical binding]; other site 311403003171 Q-loop/lid; other site 311403003172 ABC transporter signature motif; other site 311403003173 Walker B; other site 311403003174 D-loop; other site 311403003175 H-loop/switch region; other site 311403003176 aspartate aminotransferase; Provisional; Region: PRK06107 311403003177 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403003178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403003179 homodimer interface [polypeptide binding]; other site 311403003180 catalytic residue [active] 311403003181 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 311403003182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403003183 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 311403003184 putative dimerization interface [polypeptide binding]; other site 311403003185 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 311403003186 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403003187 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403003188 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 311403003189 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 311403003190 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 311403003191 classical (c) SDRs; Region: SDR_c; cd05233 311403003192 NAD(P) binding site [chemical binding]; other site 311403003193 active site 311403003194 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 311403003195 Thioesterase; Region: PKS_TE; smart00824 311403003196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403003197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403003198 putative substrate translocation pore; other site 311403003199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403003200 dimerization interface [polypeptide binding]; other site 311403003201 putative DNA binding site [nucleotide binding]; other site 311403003202 putative Zn2+ binding site [ion binding]; other site 311403003203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403003204 membrane-bound complex binding site; other site 311403003205 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 311403003206 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403003207 dimer interface [polypeptide binding]; other site 311403003208 non-prolyl cis peptide bond; other site 311403003209 active site 311403003210 insertion regions; other site 311403003211 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403003212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003213 dimer interface [polypeptide binding]; other site 311403003214 conserved gate region; other site 311403003215 putative PBP binding loops; other site 311403003216 ABC-ATPase subunit interface; other site 311403003217 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403003218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403003219 Walker A/P-loop; other site 311403003220 ATP binding site [chemical binding]; other site 311403003221 Q-loop/lid; other site 311403003222 ABC transporter signature motif; other site 311403003223 Walker B; other site 311403003224 D-loop; other site 311403003225 H-loop/switch region; other site 311403003226 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 311403003227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403003228 membrane-bound complex binding site; other site 311403003229 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403003230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 311403003231 FecR protein; Region: FecR; pfam04773 311403003232 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 311403003233 CHASE2 domain; Region: CHASE2; pfam05226 311403003234 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403003235 cyclase homology domain; Region: CHD; cd07302 311403003236 nucleotidyl binding site; other site 311403003237 metal binding site [ion binding]; metal-binding site 311403003238 dimer interface [polypeptide binding]; other site 311403003239 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403003240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403003241 DNA-binding site [nucleotide binding]; DNA binding site 311403003242 FCD domain; Region: FCD; pfam07729 311403003243 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403003244 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 311403003245 putative NAD(P) binding site [chemical binding]; other site 311403003246 active site 311403003247 putative substrate binding site [chemical binding]; other site 311403003248 classical (c) SDRs; Region: SDR_c; cd05233 311403003249 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 311403003250 NAD(P) binding site [chemical binding]; other site 311403003251 active site 311403003252 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403003253 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403003254 Walker A/P-loop; other site 311403003255 ATP binding site [chemical binding]; other site 311403003256 Q-loop/lid; other site 311403003257 ABC transporter signature motif; other site 311403003258 Walker B; other site 311403003259 D-loop; other site 311403003260 H-loop/switch region; other site 311403003261 TOBE domain; Region: TOBE_2; pfam08402 311403003262 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403003263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403003264 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003266 dimer interface [polypeptide binding]; other site 311403003267 conserved gate region; other site 311403003268 putative PBP binding loops; other site 311403003269 ABC-ATPase subunit interface; other site 311403003270 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403003271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003272 dimer interface [polypeptide binding]; other site 311403003273 conserved gate region; other site 311403003274 putative PBP binding loops; other site 311403003275 ABC-ATPase subunit interface; other site 311403003276 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 311403003277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403003278 dimerization interface [polypeptide binding]; other site 311403003279 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403003280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403003281 dimer interface [polypeptide binding]; other site 311403003282 putative CheW interface [polypeptide binding]; other site 311403003283 Predicted transcriptional regulator [Transcription]; Region: COG2378 311403003284 HTH domain; Region: HTH_11; pfam08279 311403003285 WYL domain; Region: WYL; pfam13280 311403003286 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403003287 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 311403003288 putative NAD(P) binding site [chemical binding]; other site 311403003289 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403003290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403003291 DNA-binding site [nucleotide binding]; DNA binding site 311403003292 FCD domain; Region: FCD; pfam07729 311403003293 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403003294 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403003295 inhibitor site; inhibition site 311403003296 active site 311403003297 dimer interface [polypeptide binding]; other site 311403003298 catalytic residue [active] 311403003299 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403003300 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 311403003301 NAD(P) binding site [chemical binding]; other site 311403003302 catalytic residues [active] 311403003303 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403003304 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403003305 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 311403003306 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 311403003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403003308 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 311403003309 Walker A/P-loop; other site 311403003310 ATP binding site [chemical binding]; other site 311403003311 Q-loop/lid; other site 311403003312 ABC transporter signature motif; other site 311403003313 Walker B; other site 311403003314 D-loop; other site 311403003315 H-loop/switch region; other site 311403003316 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 311403003317 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403003318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003319 dimer interface [polypeptide binding]; other site 311403003320 conserved gate region; other site 311403003321 putative PBP binding loops; other site 311403003322 ABC-ATPase subunit interface; other site 311403003323 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 311403003324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003325 dimer interface [polypeptide binding]; other site 311403003326 conserved gate region; other site 311403003327 ABC-ATPase subunit interface; other site 311403003328 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 311403003329 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 311403003330 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 311403003331 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 311403003332 conserved cys residue [active] 311403003333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 311403003334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403003335 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 311403003336 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403003337 OsmC-like protein; Region: OsmC; pfam02566 311403003338 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 311403003339 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403003340 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403003341 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403003342 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403003343 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403003344 Walker A/P-loop; other site 311403003345 ATP binding site [chemical binding]; other site 311403003346 Q-loop/lid; other site 311403003347 ABC transporter signature motif; other site 311403003348 Walker B; other site 311403003349 D-loop; other site 311403003350 H-loop/switch region; other site 311403003351 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403003352 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403003353 TM-ABC transporter signature motif; other site 311403003354 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403003355 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403003356 TM-ABC transporter signature motif; other site 311403003357 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403003358 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 311403003359 putative ligand binding site [chemical binding]; other site 311403003360 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403003361 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403003362 Walker A/P-loop; other site 311403003363 ATP binding site [chemical binding]; other site 311403003364 Q-loop/lid; other site 311403003365 ABC transporter signature motif; other site 311403003366 Walker B; other site 311403003367 D-loop; other site 311403003368 H-loop/switch region; other site 311403003369 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403003370 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403003371 Flavin binding site [chemical binding]; other site 311403003372 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 311403003373 Prostaglandin dehydrogenases; Region: PGDH; cd05288 311403003374 NAD(P) binding site [chemical binding]; other site 311403003375 substrate binding site [chemical binding]; other site 311403003376 dimer interface [polypeptide binding]; other site 311403003377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403003378 DNA binding site [nucleotide binding] 311403003379 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 311403003380 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403003381 putative ligand binding site [chemical binding]; other site 311403003382 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403003383 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403003384 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403003385 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403003386 TM-ABC transporter signature motif; other site 311403003387 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403003388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403003389 Walker A/P-loop; other site 311403003390 ATP binding site [chemical binding]; other site 311403003391 Q-loop/lid; other site 311403003392 ABC transporter signature motif; other site 311403003393 Walker B; other site 311403003394 D-loop; other site 311403003395 H-loop/switch region; other site 311403003396 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403003397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403003398 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403003399 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403003400 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403003401 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 311403003402 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403003403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403003404 NAD(P) binding site [chemical binding]; other site 311403003405 active site 311403003406 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 311403003407 triosephosphate isomerase; Provisional; Region: PRK14565 311403003408 substrate binding site [chemical binding]; other site 311403003409 dimer interface [polypeptide binding]; other site 311403003410 catalytic triad [active] 311403003411 short chain dehydrogenase; Provisional; Region: PRK06114 311403003412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403003413 NAD(P) binding site [chemical binding]; other site 311403003414 active site 311403003415 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403003416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403003417 Walker A/P-loop; other site 311403003418 ATP binding site [chemical binding]; other site 311403003419 Q-loop/lid; other site 311403003420 ABC transporter signature motif; other site 311403003421 Walker B; other site 311403003422 D-loop; other site 311403003423 H-loop/switch region; other site 311403003424 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403003425 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403003426 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403003427 ligand binding site [chemical binding]; other site 311403003428 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403003429 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403003430 TM-ABC transporter signature motif; other site 311403003431 transketolase; Reviewed; Region: PRK05899 311403003432 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 311403003433 TPP-binding site [chemical binding]; other site 311403003434 dimer interface [polypeptide binding]; other site 311403003435 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 311403003436 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 311403003437 PYR/PP interface [polypeptide binding]; other site 311403003438 dimer interface [polypeptide binding]; other site 311403003439 TPP binding site [chemical binding]; other site 311403003440 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 311403003441 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 311403003442 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 311403003443 N- and C-terminal domain interface [polypeptide binding]; other site 311403003444 active site 311403003445 MgATP binding site [chemical binding]; other site 311403003446 catalytic site [active] 311403003447 metal binding site [ion binding]; metal-binding site 311403003448 putative homotetramer interface [polypeptide binding]; other site 311403003449 putative homodimer interface [polypeptide binding]; other site 311403003450 glycerol binding site [chemical binding]; other site 311403003451 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403003452 MarR family; Region: MarR_2; pfam12802 311403003453 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403003454 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 311403003455 Class I aldolases; Region: Aldolase_Class_I; cl17187 311403003456 catalytic residue [active] 311403003457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403003458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403003459 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 311403003460 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403003461 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 311403003462 substrate binding site [chemical binding]; other site 311403003463 ATP binding site [chemical binding]; other site 311403003464 sorbitol dehydrogenase; Provisional; Region: PRK07067 311403003465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403003466 NAD(P) binding site [chemical binding]; other site 311403003467 active site 311403003468 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 311403003469 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 311403003470 putative NAD(P) binding site [chemical binding]; other site 311403003471 catalytic Zn binding site [ion binding]; other site 311403003472 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403003473 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403003474 DNA binding site [nucleotide binding] 311403003475 domain linker motif; other site 311403003476 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403003477 dimerization interface [polypeptide binding]; other site 311403003478 ligand binding site [chemical binding]; other site 311403003479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403003480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403003481 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403003482 dimerization interface [polypeptide binding]; other site 311403003483 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 311403003484 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 311403003485 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 311403003486 DctM-like transporters; Region: DctM; pfam06808 311403003487 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 311403003488 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 311403003489 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 311403003490 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403003491 catalytic residue [active] 311403003492 Dehydroquinase class II; Region: DHquinase_II; pfam01220 311403003493 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 311403003494 active site 311403003495 trimer interface [polypeptide binding]; other site 311403003496 dimer interface [polypeptide binding]; other site 311403003497 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 311403003498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 311403003499 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 311403003500 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403003501 putative ligand binding site [chemical binding]; other site 311403003502 N-terminal domain of the protein encoded by the Drosophila tweety gene and related proteins, a family of chloride ion channels; Region: Tweety_N; cl12141 311403003503 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403003504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403003505 dimer interface [polypeptide binding]; other site 311403003506 putative CheW interface [polypeptide binding]; other site 311403003507 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 311403003508 cofactor binding site; other site 311403003509 metal binding site [ion binding]; metal-binding site 311403003510 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403003511 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403003512 putative DNA binding site [nucleotide binding]; other site 311403003513 putative Zn2+ binding site [ion binding]; other site 311403003514 AsnC family; Region: AsnC_trans_reg; pfam01037 311403003515 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403003516 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 311403003517 putative DNA binding site [nucleotide binding]; other site 311403003518 putative Zn2+ binding site [ion binding]; other site 311403003519 AsnC family; Region: AsnC_trans_reg; pfam01037 311403003520 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 311403003521 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 311403003522 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 311403003523 active site 311403003524 Fe binding site [ion binding]; other site 311403003525 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 311403003526 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 311403003527 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403003528 maleylacetoacetate isomerase; Region: maiA; TIGR01262 311403003529 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 311403003530 C-terminal domain interface [polypeptide binding]; other site 311403003531 GSH binding site (G-site) [chemical binding]; other site 311403003532 putative dimer interface [polypeptide binding]; other site 311403003533 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 311403003534 dimer interface [polypeptide binding]; other site 311403003535 N-terminal domain interface [polypeptide binding]; other site 311403003536 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 311403003537 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 311403003538 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 311403003539 Putative cyclase; Region: Cyclase; pfam04199 311403003540 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 311403003541 ferrioxamine B receptor precursor protein; Provisional; Region: PRK14049 311403003542 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 311403003543 N-terminal plug; other site 311403003544 ligand-binding site [chemical binding]; other site 311403003545 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 311403003546 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 311403003547 NAD(P) binding site [chemical binding]; other site 311403003548 homotetramer interface [polypeptide binding]; other site 311403003549 homodimer interface [polypeptide binding]; other site 311403003550 active site 311403003551 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 311403003552 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403003553 ABC-ATPase subunit interface; other site 311403003554 dimer interface [polypeptide binding]; other site 311403003555 putative PBP binding regions; other site 311403003556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403003557 ABC-ATPase subunit interface; other site 311403003558 dimer interface [polypeptide binding]; other site 311403003559 putative PBP binding regions; other site 311403003560 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 311403003561 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 311403003562 siderophore binding site; other site 311403003563 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 311403003564 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 311403003565 Walker A/P-loop; other site 311403003566 ATP binding site [chemical binding]; other site 311403003567 Q-loop/lid; other site 311403003568 ABC transporter signature motif; other site 311403003569 Walker B; other site 311403003570 D-loop; other site 311403003571 H-loop/switch region; other site 311403003572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403003573 Coenzyme A binding pocket [chemical binding]; other site 311403003574 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 311403003575 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 311403003576 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403003577 Condensation domain; Region: Condensation; pfam00668 311403003578 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 311403003579 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 311403003580 acyl-activating enzyme (AAE) consensus motif; other site 311403003581 AMP binding site [chemical binding]; other site 311403003582 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 311403003583 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 311403003584 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 311403003585 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 311403003586 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 311403003587 putative efflux protein, MATE family; Region: matE; TIGR00797 311403003588 hypothetical protein; Provisional; Region: PRK05968 311403003589 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 311403003590 homodimer interface [polypeptide binding]; other site 311403003591 substrate-cofactor binding pocket; other site 311403003592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403003593 catalytic residue [active] 311403003594 diaminopimelate decarboxylase; Provisional; Region: PRK11165 311403003595 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 311403003596 active site 311403003597 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 311403003598 substrate binding site [chemical binding]; other site 311403003599 catalytic residues [active] 311403003600 dimer interface [polypeptide binding]; other site 311403003601 Cupin domain; Region: Cupin_2; cl17218 311403003602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403003603 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 311403003604 putative substrate translocation pore; other site 311403003605 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 311403003606 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403003607 NAD binding site [chemical binding]; other site 311403003608 catalytic residues [active] 311403003609 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403003610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403003611 Walker A/P-loop; other site 311403003612 ATP binding site [chemical binding]; other site 311403003613 Q-loop/lid; other site 311403003614 ABC transporter signature motif; other site 311403003615 Walker B; other site 311403003616 D-loop; other site 311403003617 H-loop/switch region; other site 311403003618 TOBE domain; Region: TOBE_2; pfam08402 311403003619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403003620 sequence-specific DNA binding site [nucleotide binding]; other site 311403003621 salt bridge; other site 311403003622 Cupin domain; Region: Cupin_2; pfam07883 311403003623 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403003624 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403003625 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403003626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003627 dimer interface [polypeptide binding]; other site 311403003628 conserved gate region; other site 311403003629 putative PBP binding loops; other site 311403003630 ABC-ATPase subunit interface; other site 311403003631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003632 putative PBP binding loops; other site 311403003633 ABC-ATPase subunit interface; other site 311403003634 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 311403003635 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 311403003636 active site 311403003637 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 311403003638 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 311403003639 dimer interface [polypeptide binding]; other site 311403003640 putative radical transfer pathway; other site 311403003641 diiron center [ion binding]; other site 311403003642 tyrosyl radical; other site 311403003643 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 311403003644 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 311403003645 Class I ribonucleotide reductase; Region: RNR_I; cd01679 311403003646 active site 311403003647 dimer interface [polypeptide binding]; other site 311403003648 catalytic residues [active] 311403003649 effector binding site; other site 311403003650 R2 peptide binding site; other site 311403003651 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 311403003652 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 311403003653 catalytic residues [active] 311403003654 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 311403003655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403003656 active site 311403003657 phosphorylation site [posttranslational modification] 311403003658 intermolecular recognition site; other site 311403003659 dimerization interface [polypeptide binding]; other site 311403003660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403003661 DNA binding residues [nucleotide binding] 311403003662 dimerization interface [polypeptide binding]; other site 311403003663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403003664 dimer interface [polypeptide binding]; other site 311403003665 phosphorylation site [posttranslational modification] 311403003666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403003667 ATP binding site [chemical binding]; other site 311403003668 Mg2+ binding site [ion binding]; other site 311403003669 G-X-G motif; other site 311403003670 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403003671 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403003672 Walker A/P-loop; other site 311403003673 ATP binding site [chemical binding]; other site 311403003674 Q-loop/lid; other site 311403003675 ABC transporter signature motif; other site 311403003676 Walker B; other site 311403003677 D-loop; other site 311403003678 H-loop/switch region; other site 311403003679 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 311403003680 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 311403003681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003682 dimer interface [polypeptide binding]; other site 311403003683 conserved gate region; other site 311403003684 putative PBP binding loops; other site 311403003685 ABC-ATPase subunit interface; other site 311403003686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003687 dimer interface [polypeptide binding]; other site 311403003688 conserved gate region; other site 311403003689 putative PBP binding loops; other site 311403003690 ABC-ATPase subunit interface; other site 311403003691 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403003692 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403003693 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 311403003694 active site 311403003695 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 311403003696 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 311403003697 metal binding site [ion binding]; metal-binding site 311403003698 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403003699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403003700 Walker A/P-loop; other site 311403003701 ATP binding site [chemical binding]; other site 311403003702 Q-loop/lid; other site 311403003703 ABC transporter signature motif; other site 311403003704 Walker B; other site 311403003705 D-loop; other site 311403003706 H-loop/switch region; other site 311403003707 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403003708 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403003709 Walker A/P-loop; other site 311403003710 ATP binding site [chemical binding]; other site 311403003711 Q-loop/lid; other site 311403003712 ABC transporter signature motif; other site 311403003713 Walker B; other site 311403003714 D-loop; other site 311403003715 H-loop/switch region; other site 311403003716 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403003717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003718 dimer interface [polypeptide binding]; other site 311403003719 conserved gate region; other site 311403003720 putative PBP binding loops; other site 311403003721 ABC-ATPase subunit interface; other site 311403003722 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403003723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003724 dimer interface [polypeptide binding]; other site 311403003725 conserved gate region; other site 311403003726 putative PBP binding loops; other site 311403003727 ABC-ATPase subunit interface; other site 311403003728 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403003729 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 311403003730 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 311403003731 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 311403003732 metal binding site [ion binding]; metal-binding site 311403003733 dimer interface [polypeptide binding]; other site 311403003734 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 311403003735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403003736 DNA-binding site [nucleotide binding]; DNA binding site 311403003737 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 311403003738 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403003739 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403003740 Walker A/P-loop; other site 311403003741 ATP binding site [chemical binding]; other site 311403003742 Q-loop/lid; other site 311403003743 ABC transporter signature motif; other site 311403003744 Walker B; other site 311403003745 D-loop; other site 311403003746 H-loop/switch region; other site 311403003747 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403003748 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403003749 Walker A/P-loop; other site 311403003750 ATP binding site [chemical binding]; other site 311403003751 Q-loop/lid; other site 311403003752 ABC transporter signature motif; other site 311403003753 Walker B; other site 311403003754 D-loop; other site 311403003755 H-loop/switch region; other site 311403003756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403003757 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403003758 TM-ABC transporter signature motif; other site 311403003759 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403003760 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403003761 TM-ABC transporter signature motif; other site 311403003762 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403003763 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 311403003764 putative ligand binding site [chemical binding]; other site 311403003765 MarR family; Region: MarR_2; cl17246 311403003766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403003767 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 311403003768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403003769 FAD binding site [chemical binding]; other site 311403003770 substrate binding pocket [chemical binding]; other site 311403003771 catalytic base [active] 311403003772 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 311403003773 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 311403003774 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403003775 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403003776 Amino acid synthesis; Region: AA_synth; pfam06684 311403003777 Amino acid synthesis; Region: AA_synth; pfam06684 311403003778 hypothetical protein; Provisional; Region: PRK04334 311403003779 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403003780 MarR family; Region: MarR; pfam01047 311403003781 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 311403003782 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 311403003783 FAD binding pocket [chemical binding]; other site 311403003784 FAD binding motif [chemical binding]; other site 311403003785 phosphate binding motif [ion binding]; other site 311403003786 beta-alpha-beta structure motif; other site 311403003787 NAD binding pocket [chemical binding]; other site 311403003788 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403003789 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 311403003790 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 311403003791 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403003792 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403003793 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 311403003794 Cytochrome c; Region: Cytochrom_C; pfam00034 311403003795 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 311403003796 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403003797 catalytic loop [active] 311403003798 iron binding site [ion binding]; other site 311403003799 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 311403003800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403003801 MarR family; Region: MarR; pfam01047 311403003802 Protein of unknown function (DUF2498); Region: DUF2498; cl11671 311403003803 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403003804 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 311403003805 putative ligand binding site [chemical binding]; other site 311403003806 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403003807 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403003808 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403003809 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403003810 TM-ABC transporter signature motif; other site 311403003811 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403003812 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403003813 TM-ABC transporter signature motif; other site 311403003814 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 311403003815 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403003816 Walker A/P-loop; other site 311403003817 ATP binding site [chemical binding]; other site 311403003818 Q-loop/lid; other site 311403003819 ABC transporter signature motif; other site 311403003820 Walker B; other site 311403003821 D-loop; other site 311403003822 H-loop/switch region; other site 311403003823 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 311403003824 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403003825 Walker A/P-loop; other site 311403003826 ATP binding site [chemical binding]; other site 311403003827 Q-loop/lid; other site 311403003828 ABC transporter signature motif; other site 311403003829 Walker B; other site 311403003830 D-loop; other site 311403003831 H-loop/switch region; other site 311403003832 amidase; Provisional; Region: PRK07235 311403003833 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 311403003834 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 311403003835 choline dehydrogenase; Validated; Region: PRK02106 311403003836 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 311403003837 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403003838 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403003839 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 311403003840 NAD(P) binding site [chemical binding]; other site 311403003841 catalytic residues [active] 311403003842 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403003843 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403003844 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403003845 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403003846 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403003847 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403003848 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403003849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403003850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403003851 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 311403003852 Cupin domain; Region: Cupin_2; pfam07883 311403003853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403003854 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403003855 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403003856 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403003857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003858 dimer interface [polypeptide binding]; other site 311403003859 conserved gate region; other site 311403003860 putative PBP binding loops; other site 311403003861 ABC-ATPase subunit interface; other site 311403003862 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003864 dimer interface [polypeptide binding]; other site 311403003865 conserved gate region; other site 311403003866 putative PBP binding loops; other site 311403003867 ABC-ATPase subunit interface; other site 311403003868 Melibiase; Region: Melibiase; pfam02065 311403003869 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 311403003870 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403003871 Walker A/P-loop; other site 311403003872 ATP binding site [chemical binding]; other site 311403003873 Q-loop/lid; other site 311403003874 ABC transporter signature motif; other site 311403003875 Walker B; other site 311403003876 D-loop; other site 311403003877 H-loop/switch region; other site 311403003878 TOBE domain; Region: TOBE_2; pfam08402 311403003879 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 311403003880 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 311403003881 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 311403003882 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 311403003883 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 311403003884 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 311403003885 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403003886 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403003887 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403003888 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403003889 Walker A/P-loop; other site 311403003890 ATP binding site [chemical binding]; other site 311403003891 Q-loop/lid; other site 311403003892 ABC transporter signature motif; other site 311403003893 Walker B; other site 311403003894 D-loop; other site 311403003895 H-loop/switch region; other site 311403003896 TOBE domain; Region: TOBE_2; pfam08402 311403003897 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003899 dimer interface [polypeptide binding]; other site 311403003900 conserved gate region; other site 311403003901 putative PBP binding loops; other site 311403003902 ABC-ATPase subunit interface; other site 311403003903 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403003904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403003905 dimer interface [polypeptide binding]; other site 311403003906 conserved gate region; other site 311403003907 putative PBP binding loops; other site 311403003908 ABC-ATPase subunit interface; other site 311403003909 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403003910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403003911 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403003912 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403003913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403003914 DNA binding site [nucleotide binding] 311403003915 domain linker motif; other site 311403003916 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403003917 dimerization interface [polypeptide binding]; other site 311403003918 ligand binding site [chemical binding]; other site 311403003919 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 311403003920 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 311403003921 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403003922 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 311403003923 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 311403003924 active site 311403003925 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 311403003926 dimer interface [polypeptide binding]; other site 311403003927 substrate binding site [chemical binding]; other site 311403003928 catalytic residues [active] 311403003929 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 311403003930 AsnC family; Region: AsnC_trans_reg; pfam01037 311403003931 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 311403003932 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403003933 inhibitor-cofactor binding pocket; inhibition site 311403003934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403003935 catalytic residue [active] 311403003936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403003937 non-specific DNA binding site [nucleotide binding]; other site 311403003938 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 311403003939 salt bridge; other site 311403003940 sequence-specific DNA binding site [nucleotide binding]; other site 311403003941 Cupin domain; Region: Cupin_2; pfam07883 311403003942 Porin subfamily; Region: Porin_2; pfam02530 311403003943 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 311403003944 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 311403003945 Ligand binding site; other site 311403003946 Putative Catalytic site; other site 311403003947 DXD motif; other site 311403003948 Predicted membrane protein [Function unknown]; Region: COG2246 311403003949 GtrA-like protein; Region: GtrA; pfam04138 311403003950 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 311403003951 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 311403003952 metal binding site [ion binding]; metal-binding site 311403003953 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 311403003954 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 311403003955 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 311403003956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403003957 ABC-ATPase subunit interface; other site 311403003958 dimer interface [polypeptide binding]; other site 311403003959 putative PBP binding regions; other site 311403003960 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 311403003961 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403003962 ABC-ATPase subunit interface; other site 311403003963 dimer interface [polypeptide binding]; other site 311403003964 putative PBP binding regions; other site 311403003965 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 311403003966 metal binding site 2 [ion binding]; metal-binding site 311403003967 putative DNA binding helix; other site 311403003968 metal binding site 1 [ion binding]; metal-binding site 311403003969 dimer interface [polypeptide binding]; other site 311403003970 structural Zn2+ binding site [ion binding]; other site 311403003971 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 311403003972 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 311403003973 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 311403003974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403003975 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403003976 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 311403003977 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 311403003978 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403003979 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 311403003980 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 311403003981 conserved cys residue [active] 311403003982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403003983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403003984 non-specific DNA binding site [nucleotide binding]; other site 311403003985 salt bridge; other site 311403003986 sequence-specific DNA binding site [nucleotide binding]; other site 311403003987 Cupin domain; Region: Cupin_2; pfam07883 311403003988 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 311403003989 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 311403003990 putative active site [active] 311403003991 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 311403003992 domain_subunit interface; other site 311403003993 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 311403003994 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 311403003995 active site 311403003996 FMN binding site [chemical binding]; other site 311403003997 substrate binding site [chemical binding]; other site 311403003998 3Fe-4S cluster binding site [ion binding]; other site 311403003999 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 311403004000 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 311403004001 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 311403004002 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 311403004003 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 311403004004 putative active site [active] 311403004005 putative substrate binding site [chemical binding]; other site 311403004006 putative cosubstrate binding site; other site 311403004007 catalytic site [active] 311403004008 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 311403004009 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 311403004010 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 311403004011 homodimer interface [polypeptide binding]; other site 311403004012 NADP binding site [chemical binding]; other site 311403004013 substrate binding site [chemical binding]; other site 311403004014 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 311403004015 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403004016 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 311403004017 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 311403004018 FMN-binding pocket [chemical binding]; other site 311403004019 flavin binding motif; other site 311403004020 phosphate binding motif [ion binding]; other site 311403004021 beta-alpha-beta structure motif; other site 311403004022 NAD binding pocket [chemical binding]; other site 311403004023 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403004024 catalytic loop [active] 311403004025 iron binding site [ion binding]; other site 311403004026 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 311403004027 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 311403004028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403004029 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403004030 PAS fold; Region: PAS_3; pfam08447 311403004031 putative active site [active] 311403004032 heme pocket [chemical binding]; other site 311403004033 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403004034 putative CheW interface [polypeptide binding]; other site 311403004035 Uncharacterized conserved protein [Function unknown]; Region: COG3665 311403004036 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 311403004037 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403004038 Amino acid permease; Region: AA_permease_2; pfam13520 311403004039 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 311403004040 putative active site [active] 311403004041 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 311403004042 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 311403004043 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 311403004044 Walker A/P-loop; other site 311403004045 ATP binding site [chemical binding]; other site 311403004046 Q-loop/lid; other site 311403004047 ABC transporter signature motif; other site 311403004048 Walker B; other site 311403004049 D-loop; other site 311403004050 H-loop/switch region; other site 311403004051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004052 dimer interface [polypeptide binding]; other site 311403004053 conserved gate region; other site 311403004054 ABC-ATPase subunit interface; other site 311403004055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004056 dimer interface [polypeptide binding]; other site 311403004057 conserved gate region; other site 311403004058 putative PBP binding loops; other site 311403004059 ABC-ATPase subunit interface; other site 311403004060 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 311403004061 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 311403004062 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 311403004063 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 311403004064 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 311403004065 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 311403004066 active sites [active] 311403004067 tetramer interface [polypeptide binding]; other site 311403004068 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 311403004069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004070 DNA-binding site [nucleotide binding]; DNA binding site 311403004071 UTRA domain; Region: UTRA; pfam07702 311403004072 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 311403004073 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 311403004074 dimer interaction site [polypeptide binding]; other site 311403004075 substrate-binding tunnel; other site 311403004076 active site 311403004077 catalytic site [active] 311403004078 substrate binding site [chemical binding]; other site 311403004079 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403004080 classical (c) SDRs; Region: SDR_c; cd05233 311403004081 NAD(P) binding site [chemical binding]; other site 311403004082 active site 311403004083 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 311403004084 Coenzyme A transferase; Region: CoA_trans; smart00882 311403004085 Coenzyme A transferase; Region: CoA_trans; cl17247 311403004086 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 311403004087 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 311403004088 Walker A/P-loop; other site 311403004089 ATP binding site [chemical binding]; other site 311403004090 Q-loop/lid; other site 311403004091 ABC transporter signature motif; other site 311403004092 Walker B; other site 311403004093 D-loop; other site 311403004094 H-loop/switch region; other site 311403004095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004096 dimer interface [polypeptide binding]; other site 311403004097 conserved gate region; other site 311403004098 putative PBP binding loops; other site 311403004099 ABC-ATPase subunit interface; other site 311403004100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004101 dimer interface [polypeptide binding]; other site 311403004102 conserved gate region; other site 311403004103 putative PBP binding loops; other site 311403004104 ABC-ATPase subunit interface; other site 311403004105 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 311403004106 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 311403004107 active sites [active] 311403004108 tetramer interface [polypeptide binding]; other site 311403004109 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 311403004110 CoA-transferase family III; Region: CoA_transf_3; pfam02515 311403004111 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 311403004112 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 311403004113 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 311403004114 enoyl-CoA hydratase; Provisional; Region: PRK05862 311403004115 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403004116 substrate binding site [chemical binding]; other site 311403004117 oxyanion hole (OAH) forming residues; other site 311403004118 trimer interface [polypeptide binding]; other site 311403004119 HipA N-terminal domain; Region: Couple_hipA; pfam13657 311403004120 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 311403004121 HipA-like N-terminal domain; Region: HipA_N; pfam07805 311403004122 HipA-like C-terminal domain; Region: HipA_C; pfam07804 311403004123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403004124 non-specific DNA binding site [nucleotide binding]; other site 311403004125 salt bridge; other site 311403004126 sequence-specific DNA binding site [nucleotide binding]; other site 311403004127 galactarate dehydratase; Region: galactar-dH20; TIGR03248 311403004128 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 311403004129 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 311403004130 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 311403004131 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 311403004132 putative NAD(P) binding site [chemical binding]; other site 311403004133 catalytic Zn binding site [ion binding]; other site 311403004134 structural Zn binding site [ion binding]; other site 311403004135 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403004136 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403004137 substrate binding pocket [chemical binding]; other site 311403004138 membrane-bound complex binding site; other site 311403004139 hinge residues; other site 311403004140 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403004141 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403004142 Walker A/P-loop; other site 311403004143 ATP binding site [chemical binding]; other site 311403004144 Q-loop/lid; other site 311403004145 ABC transporter signature motif; other site 311403004146 Walker B; other site 311403004147 D-loop; other site 311403004148 H-loop/switch region; other site 311403004149 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403004150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004151 dimer interface [polypeptide binding]; other site 311403004152 conserved gate region; other site 311403004153 putative PBP binding loops; other site 311403004154 ABC-ATPase subunit interface; other site 311403004155 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403004156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004157 dimer interface [polypeptide binding]; other site 311403004158 conserved gate region; other site 311403004159 putative PBP binding loops; other site 311403004160 ABC-ATPase subunit interface; other site 311403004161 altronate oxidoreductase; Provisional; Region: PRK03643 311403004162 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 311403004163 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403004164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004165 DNA-binding site [nucleotide binding]; DNA binding site 311403004166 FCD domain; Region: FCD; pfam07729 311403004167 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 311403004168 Strictosidine synthase; Region: Str_synth; pfam03088 311403004169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403004170 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403004171 TM-ABC transporter signature motif; other site 311403004172 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403004173 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403004174 TM-ABC transporter signature motif; other site 311403004175 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403004176 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403004177 Walker A/P-loop; other site 311403004178 ATP binding site [chemical binding]; other site 311403004179 Q-loop/lid; other site 311403004180 ABC transporter signature motif; other site 311403004181 Walker B; other site 311403004182 D-loop; other site 311403004183 H-loop/switch region; other site 311403004184 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403004185 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403004186 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403004187 GAF domain; Region: GAF; pfam01590 311403004188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 311403004189 Histidine kinase; Region: HisKA_3; pfam07730 311403004190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403004191 ATP binding site [chemical binding]; other site 311403004192 Mg2+ binding site [ion binding]; other site 311403004193 G-X-G motif; other site 311403004194 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403004195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403004196 active site 311403004197 phosphorylation site [posttranslational modification] 311403004198 intermolecular recognition site; other site 311403004199 dimerization interface [polypeptide binding]; other site 311403004200 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 311403004201 DNA binding residues [nucleotide binding] 311403004202 isocitrate lyase; Provisional; Region: PRK15063 311403004203 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 311403004204 tetramer interface [polypeptide binding]; other site 311403004205 active site 311403004206 Mg2+/Mn2+ binding site [ion binding]; other site 311403004207 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403004208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403004209 non-specific DNA binding site [nucleotide binding]; other site 311403004210 salt bridge; other site 311403004211 sequence-specific DNA binding site [nucleotide binding]; other site 311403004212 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 311403004213 Domain of unknown function (DUF955); Region: DUF955; pfam06114 311403004214 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 311403004215 Phospholipid methyltransferase; Region: PEMT; cl17370 311403004216 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 311403004217 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 311403004218 ligand binding site [chemical binding]; other site 311403004219 Uncharacterized conserved protein [Function unknown]; Region: COG3743 311403004220 Uncharacterized conserved protein [Function unknown]; Region: COG3743 311403004221 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403004222 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 311403004223 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403004224 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403004225 Walker A/P-loop; other site 311403004226 ATP binding site [chemical binding]; other site 311403004227 Q-loop/lid; other site 311403004228 ABC transporter signature motif; other site 311403004229 Walker B; other site 311403004230 D-loop; other site 311403004231 H-loop/switch region; other site 311403004232 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403004233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403004234 Walker A/P-loop; other site 311403004235 ATP binding site [chemical binding]; other site 311403004236 Q-loop/lid; other site 311403004237 ABC transporter signature motif; other site 311403004238 Walker B; other site 311403004239 D-loop; other site 311403004240 H-loop/switch region; other site 311403004241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403004242 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403004243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004244 dimer interface [polypeptide binding]; other site 311403004245 conserved gate region; other site 311403004246 putative PBP binding loops; other site 311403004247 ABC-ATPase subunit interface; other site 311403004248 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403004249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004250 dimer interface [polypeptide binding]; other site 311403004251 conserved gate region; other site 311403004252 putative PBP binding loops; other site 311403004253 ABC-ATPase subunit interface; other site 311403004254 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 311403004255 Autoinducer binding domain; Region: Autoind_bind; pfam03472 311403004256 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403004257 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403004258 DNA binding residues [nucleotide binding] 311403004259 dimerization interface [polypeptide binding]; other site 311403004260 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 311403004261 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 311403004262 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 311403004263 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 311403004264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403004265 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 311403004266 dimerization interface [polypeptide binding]; other site 311403004267 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 311403004268 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 311403004269 catalytic residue [active] 311403004270 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 311403004271 catalytic residues [active] 311403004272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403004273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403004274 peroxiredoxin; Region: AhpC; TIGR03137 311403004275 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 311403004276 dimer interface [polypeptide binding]; other site 311403004277 decamer (pentamer of dimers) interface [polypeptide binding]; other site 311403004278 catalytic triad [active] 311403004279 peroxidatic and resolving cysteines [active] 311403004280 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 311403004281 active site 311403004282 NTP binding site [chemical binding]; other site 311403004283 metal binding triad [ion binding]; metal-binding site 311403004284 antibiotic binding site [chemical binding]; other site 311403004285 Autoinducer synthetase; Region: Autoind_synth; cl17404 311403004286 Autoinducer binding domain; Region: Autoind_bind; pfam03472 311403004287 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403004288 DNA binding residues [nucleotide binding] 311403004289 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403004290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403004291 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403004292 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403004293 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403004294 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403004295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403004296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403004297 putative substrate translocation pore; other site 311403004298 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 311403004299 active site 311403004300 catalytic site [active] 311403004301 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 311403004302 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 311403004303 AAA domain; Region: AAA_17; pfam13207 311403004304 AAA domain; Region: AAA_18; pfam13238 311403004305 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 311403004306 B12 binding site [chemical binding]; other site 311403004307 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 311403004308 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 311403004309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403004310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403004311 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 311403004312 Walker A/P-loop; other site 311403004313 ATP binding site [chemical binding]; other site 311403004314 Q-loop/lid; other site 311403004315 ABC transporter signature motif; other site 311403004316 Walker B; other site 311403004317 D-loop; other site 311403004318 H-loop/switch region; other site 311403004319 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 311403004320 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 311403004321 HSP70 interaction site [polypeptide binding]; other site 311403004322 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 311403004323 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 311403004324 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403004325 protein binding site [polypeptide binding]; other site 311403004326 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403004327 protein binding site [polypeptide binding]; other site 311403004328 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 311403004329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403004330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403004331 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 311403004332 putative effector binding pocket; other site 311403004333 putative dimerization interface [polypeptide binding]; other site 311403004334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403004335 putative substrate translocation pore; other site 311403004336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403004337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403004338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403004339 active site 311403004340 catalytic tetrad [active] 311403004341 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 311403004342 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 311403004343 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 311403004344 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403004345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004346 DNA-binding site [nucleotide binding]; DNA binding site 311403004347 FCD domain; Region: FCD; pfam07729 311403004348 mannonate dehydratase; Provisional; Region: PRK03906 311403004349 mannonate dehydratase; Region: uxuA; TIGR00695 311403004350 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 311403004351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403004352 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 311403004353 putative active site [active] 311403004354 heme pocket [chemical binding]; other site 311403004355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403004356 putative active site [active] 311403004357 heme pocket [chemical binding]; other site 311403004358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403004359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403004360 metal binding site [ion binding]; metal-binding site 311403004361 active site 311403004362 I-site; other site 311403004363 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403004364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 311403004365 putative dimer interface [polypeptide binding]; other site 311403004366 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403004367 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 311403004368 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 311403004369 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 311403004370 kynureninase; Region: kynureninase; TIGR01814 311403004371 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403004372 catalytic residue [active] 311403004373 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403004374 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 311403004375 TM-ABC transporter signature motif; other site 311403004376 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 311403004377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403004378 Walker A/P-loop; other site 311403004379 ATP binding site [chemical binding]; other site 311403004380 Q-loop/lid; other site 311403004381 ABC transporter signature motif; other site 311403004382 Walker B; other site 311403004383 D-loop; other site 311403004384 H-loop/switch region; other site 311403004385 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 311403004386 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403004387 zinc binding site [ion binding]; other site 311403004388 putative ligand binding site [chemical binding]; other site 311403004389 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403004390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004391 DNA-binding site [nucleotide binding]; DNA binding site 311403004392 FCD domain; Region: FCD; pfam07729 311403004393 DDE domain; Region: DDE_Tnp_IS240; pfam13610 311403004394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 311403004395 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403004396 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 311403004397 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 311403004398 YceI-like domain; Region: YceI; smart00867 311403004399 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 311403004400 YceI-like domain; Region: YceI; smart00867 311403004401 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 311403004402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403004403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403004404 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 311403004405 putative dimerization interface [polypeptide binding]; other site 311403004406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 311403004407 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403004408 NMT1-like family; Region: NMT1_2; pfam13379 311403004409 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403004410 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403004411 Walker A/P-loop; other site 311403004412 ATP binding site [chemical binding]; other site 311403004413 Q-loop/lid; other site 311403004414 ABC transporter signature motif; other site 311403004415 Walker B; other site 311403004416 D-loop; other site 311403004417 H-loop/switch region; other site 311403004418 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 311403004419 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403004420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403004421 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403004422 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403004423 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403004424 DNA binding site [nucleotide binding] 311403004425 domain linker motif; other site 311403004426 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 311403004427 putative ligand binding site [chemical binding]; other site 311403004428 putative dimerization interface [polypeptide binding]; other site 311403004429 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403004430 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 311403004431 putative ligand binding site [chemical binding]; other site 311403004432 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403004433 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403004434 TM-ABC transporter signature motif; other site 311403004435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403004436 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 311403004437 Walker A/P-loop; other site 311403004438 ATP binding site [chemical binding]; other site 311403004439 Q-loop/lid; other site 311403004440 ABC transporter signature motif; other site 311403004441 Walker B; other site 311403004442 D-loop; other site 311403004443 H-loop/switch region; other site 311403004444 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 311403004445 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403004446 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403004447 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403004448 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403004449 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403004450 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 311403004451 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 311403004452 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 311403004453 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 311403004454 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403004455 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403004456 dimerization interface [polypeptide binding]; other site 311403004457 putative DNA binding site [nucleotide binding]; other site 311403004458 putative Zn2+ binding site [ion binding]; other site 311403004459 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 311403004460 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403004461 putative active site pocket [active] 311403004462 metal binding site [ion binding]; metal-binding site 311403004463 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 311403004464 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 311403004465 cell density-dependent motility repressor; Provisional; Region: PRK10082 311403004466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403004467 LysR substrate binding domain; Region: LysR_substrate; pfam03466 311403004468 dimerization interface [polypeptide binding]; other site 311403004469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403004470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403004471 short chain dehydrogenase; Provisional; Region: PRK08263 311403004472 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 311403004473 NADP binding site [chemical binding]; other site 311403004474 active site 311403004475 steroid binding site; other site 311403004476 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 311403004477 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 311403004478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403004479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403004480 non-specific DNA binding site [nucleotide binding]; other site 311403004481 salt bridge; other site 311403004482 sequence-specific DNA binding site [nucleotide binding]; other site 311403004483 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 311403004484 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403004485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403004486 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 311403004487 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 311403004488 nucleotide binding site [chemical binding]; other site 311403004489 SulA interaction site; other site 311403004490 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 311403004491 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 311403004492 dimer interface [polypeptide binding]; other site 311403004493 active site 311403004494 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403004495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403004496 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403004497 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403004498 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403004499 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 311403004500 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 311403004501 Amidase; Region: Amidase; pfam01425 311403004502 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 311403004503 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 311403004504 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403004505 Walker A/P-loop; other site 311403004506 ATP binding site [chemical binding]; other site 311403004507 Q-loop/lid; other site 311403004508 ABC transporter signature motif; other site 311403004509 Walker B; other site 311403004510 D-loop; other site 311403004511 H-loop/switch region; other site 311403004512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403004513 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403004514 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403004515 Walker A/P-loop; other site 311403004516 ATP binding site [chemical binding]; other site 311403004517 Q-loop/lid; other site 311403004518 ABC transporter signature motif; other site 311403004519 Walker B; other site 311403004520 D-loop; other site 311403004521 H-loop/switch region; other site 311403004522 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403004523 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403004524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004525 dimer interface [polypeptide binding]; other site 311403004526 conserved gate region; other site 311403004527 putative PBP binding loops; other site 311403004528 ABC-ATPase subunit interface; other site 311403004529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403004530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004531 dimer interface [polypeptide binding]; other site 311403004532 conserved gate region; other site 311403004533 putative PBP binding loops; other site 311403004534 ABC-ATPase subunit interface; other site 311403004535 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403004536 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 311403004537 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 311403004538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004539 DNA-binding site [nucleotide binding]; DNA binding site 311403004540 FCD domain; Region: FCD; pfam07729 311403004541 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403004542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 311403004543 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 311403004544 DDE domain; Region: DDE_Tnp_IS240; pfam13610 311403004545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 311403004546 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403004547 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 311403004548 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 311403004549 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403004550 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403004551 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403004552 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403004553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403004554 active site 311403004555 phosphorylation site [posttranslational modification] 311403004556 intermolecular recognition site; other site 311403004557 dimerization interface [polypeptide binding]; other site 311403004558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403004559 DNA binding site [nucleotide binding] 311403004560 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 311403004561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403004562 ATP binding site [chemical binding]; other site 311403004563 Mg2+ binding site [ion binding]; other site 311403004564 G-X-G motif; other site 311403004565 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 311403004566 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403004567 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 311403004568 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 311403004569 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403004570 carboxyltransferase (CT) interaction site; other site 311403004571 biotinylation site [posttranslational modification]; other site 311403004572 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 311403004573 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 311403004574 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 311403004575 hypothetical protein; Provisional; Region: PRK05463 311403004576 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 311403004577 putative active site [active] 311403004578 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 311403004579 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403004580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004581 DNA-binding site [nucleotide binding]; DNA binding site 311403004582 FCD domain; Region: FCD; pfam07729 311403004583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403004584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403004585 dimer interface [polypeptide binding]; other site 311403004586 phosphorylation site [posttranslational modification] 311403004587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403004588 ATP binding site [chemical binding]; other site 311403004589 Mg2+ binding site [ion binding]; other site 311403004590 G-X-G motif; other site 311403004591 Response regulator receiver domain; Region: Response_reg; pfam00072 311403004592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403004593 active site 311403004594 phosphorylation site [posttranslational modification] 311403004595 intermolecular recognition site; other site 311403004596 dimerization interface [polypeptide binding]; other site 311403004597 Response regulator receiver domain; Region: Response_reg; pfam00072 311403004598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403004599 active site 311403004600 phosphorylation site [posttranslational modification] 311403004601 intermolecular recognition site; other site 311403004602 dimerization interface [polypeptide binding]; other site 311403004603 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 311403004604 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 311403004605 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 311403004606 transmembrane helices; other site 311403004607 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 311403004608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403004609 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403004610 ligand binding site [chemical binding]; other site 311403004611 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403004612 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403004613 Walker A/P-loop; other site 311403004614 ATP binding site [chemical binding]; other site 311403004615 Q-loop/lid; other site 311403004616 ABC transporter signature motif; other site 311403004617 Walker B; other site 311403004618 D-loop; other site 311403004619 H-loop/switch region; other site 311403004620 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403004621 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403004622 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403004623 TM-ABC transporter signature motif; other site 311403004624 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403004625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403004626 DNA binding residues [nucleotide binding] 311403004627 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403004628 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403004629 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403004630 active site 311403004631 catalytic tetrad [active] 311403004632 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 311403004633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403004634 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 311403004635 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 311403004636 putative active site; other site 311403004637 catalytic residue [active] 311403004638 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 311403004639 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 311403004640 putative N- and C-terminal domain interface [polypeptide binding]; other site 311403004641 putative active site [active] 311403004642 MgATP binding site [chemical binding]; other site 311403004643 catalytic site [active] 311403004644 metal binding site [ion binding]; metal-binding site 311403004645 putative xylulose binding site [chemical binding]; other site 311403004646 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 311403004647 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403004648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403004649 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403004650 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 311403004651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004652 putative PBP binding loops; other site 311403004653 dimer interface [polypeptide binding]; other site 311403004654 ABC-ATPase subunit interface; other site 311403004655 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403004656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004657 dimer interface [polypeptide binding]; other site 311403004658 conserved gate region; other site 311403004659 putative PBP binding loops; other site 311403004660 ABC-ATPase subunit interface; other site 311403004661 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403004662 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403004663 Walker A/P-loop; other site 311403004664 ATP binding site [chemical binding]; other site 311403004665 Q-loop/lid; other site 311403004666 ABC transporter signature motif; other site 311403004667 Walker B; other site 311403004668 D-loop; other site 311403004669 H-loop/switch region; other site 311403004670 TOBE domain; Region: TOBE_2; pfam08402 311403004671 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403004672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004673 DNA-binding site [nucleotide binding]; DNA binding site 311403004674 FCD domain; Region: FCD; pfam07729 311403004675 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403004676 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 311403004677 active site pocket [active] 311403004678 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 311403004679 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 311403004680 NADP binding site [chemical binding]; other site 311403004681 homodimer interface [polypeptide binding]; other site 311403004682 active site 311403004683 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 311403004684 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 311403004685 putative NAD(P) binding site [chemical binding]; other site 311403004686 catalytic Zn binding site [ion binding]; other site 311403004687 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403004688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403004689 NAD(P) binding site [chemical binding]; other site 311403004690 active site 311403004691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403004692 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403004693 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 311403004694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403004695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403004696 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403004697 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403004698 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403004699 Protein of unknown function (DUF993); Region: DUF993; pfam06187 311403004700 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403004701 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 311403004702 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 311403004703 dimerization interface [polypeptide binding]; other site 311403004704 ligand binding site [chemical binding]; other site 311403004705 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 311403004706 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 311403004707 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403004708 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 311403004709 putative C-terminal domain interface [polypeptide binding]; other site 311403004710 putative GSH binding site (G-site) [chemical binding]; other site 311403004711 putative dimer interface [polypeptide binding]; other site 311403004712 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 311403004713 putative N-terminal domain interface [polypeptide binding]; other site 311403004714 putative dimer interface [polypeptide binding]; other site 311403004715 putative substrate binding pocket (H-site) [chemical binding]; other site 311403004716 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403004717 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403004718 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 311403004719 putative effector binding pocket; other site 311403004720 putative dimerization interface [polypeptide binding]; other site 311403004721 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 311403004722 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 311403004723 N- and C-terminal domain interface [polypeptide binding]; other site 311403004724 putative active site [active] 311403004725 putative MgATP binding site [chemical binding]; other site 311403004726 putative catalytic site [active] 311403004727 metal binding site [ion binding]; metal-binding site 311403004728 putative carbohydrate binding site [chemical binding]; other site 311403004729 Domain of unknown function (DUF718); Region: DUF718; pfam05336 311403004730 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403004731 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403004732 TM-ABC transporter signature motif; other site 311403004733 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403004734 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403004735 TM-ABC transporter signature motif; other site 311403004736 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403004737 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403004738 Walker A/P-loop; other site 311403004739 ATP binding site [chemical binding]; other site 311403004740 Q-loop/lid; other site 311403004741 ABC transporter signature motif; other site 311403004742 Walker B; other site 311403004743 D-loop; other site 311403004744 H-loop/switch region; other site 311403004745 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403004746 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 311403004747 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 311403004748 ligand binding site [chemical binding]; other site 311403004749 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403004750 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403004751 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403004752 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 311403004753 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 311403004754 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 311403004755 putative NAD(P) binding site [chemical binding]; other site 311403004756 active site 311403004757 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 311403004758 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 311403004759 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_36; cd04695 311403004760 nudix motif; other site 311403004761 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403004762 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 311403004763 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 311403004764 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 311403004765 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 311403004766 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403004767 MarR family; Region: MarR_2; pfam12802 311403004768 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403004769 N-acetylmannosamine kinase; Provisional; Region: PRK05082 311403004770 nucleotide binding site [chemical binding]; other site 311403004771 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 311403004772 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403004773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403004774 S-adenosylmethionine binding site [chemical binding]; other site 311403004775 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 311403004776 catalytic residues [active] 311403004777 dimer interface [polypeptide binding]; other site 311403004778 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403004779 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403004780 Walker A/P-loop; other site 311403004781 ATP binding site [chemical binding]; other site 311403004782 Q-loop/lid; other site 311403004783 ABC transporter signature motif; other site 311403004784 Walker B; other site 311403004785 D-loop; other site 311403004786 H-loop/switch region; other site 311403004787 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403004788 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403004789 Walker A/P-loop; other site 311403004790 ATP binding site [chemical binding]; other site 311403004791 Q-loop/lid; other site 311403004792 ABC transporter signature motif; other site 311403004793 Walker B; other site 311403004794 D-loop; other site 311403004795 H-loop/switch region; other site 311403004796 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403004797 Uncharacterized conserved protein [Function unknown]; Region: COG3342 311403004798 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 311403004799 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 311403004800 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 311403004801 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403004802 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004804 dimer interface [polypeptide binding]; other site 311403004805 conserved gate region; other site 311403004806 putative PBP binding loops; other site 311403004807 ABC-ATPase subunit interface; other site 311403004808 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004810 dimer interface [polypeptide binding]; other site 311403004811 conserved gate region; other site 311403004812 putative PBP binding loops; other site 311403004813 ABC-ATPase subunit interface; other site 311403004814 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403004815 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 311403004816 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403004817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004818 DNA-binding site [nucleotide binding]; DNA binding site 311403004819 FCD domain; Region: FCD; pfam07729 311403004820 Uncharacterized conserved protein [Function unknown]; Region: COG5476 311403004821 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 311403004822 MlrC C-terminus; Region: MlrC_C; pfam07171 311403004823 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403004824 ROK family; Region: ROK; pfam00480 311403004825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403004826 dimerization interface [polypeptide binding]; other site 311403004827 putative DNA binding site [nucleotide binding]; other site 311403004828 putative Zn2+ binding site [ion binding]; other site 311403004829 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 311403004830 putative hydrophobic ligand binding site [chemical binding]; other site 311403004831 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 311403004832 nucleoside/Zn binding site; other site 311403004833 dimer interface [polypeptide binding]; other site 311403004834 catalytic motif [active] 311403004835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403004836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403004837 putative substrate translocation pore; other site 311403004838 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403004839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403004840 DNA-binding site [nucleotide binding]; DNA binding site 311403004841 FCD domain; Region: FCD; pfam07729 311403004842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403004843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403004844 putative substrate translocation pore; other site 311403004845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403004846 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 311403004847 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 311403004848 inhibitor binding site; inhibition site 311403004849 catalytic Zn binding site [ion binding]; other site 311403004850 structural Zn binding site [ion binding]; other site 311403004851 NADP binding site [chemical binding]; other site 311403004852 tetramer interface [polypeptide binding]; other site 311403004853 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 311403004854 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 311403004855 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403004856 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403004857 ligand binding site [chemical binding]; other site 311403004858 flexible hinge region; other site 311403004859 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 311403004860 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 311403004861 PLD-like domain; Region: PLDc_2; pfam13091 311403004862 putative active site [active] 311403004863 catalytic site [active] 311403004864 PLD-like domain; Region: PLDc_2; pfam13091 311403004865 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 311403004866 putative active site [active] 311403004867 catalytic site [active] 311403004868 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 311403004869 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 311403004870 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 311403004871 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 311403004872 Walker A/P-loop; other site 311403004873 ATP binding site [chemical binding]; other site 311403004874 Q-loop/lid; other site 311403004875 ABC transporter signature motif; other site 311403004876 Walker B; other site 311403004877 D-loop; other site 311403004878 H-loop/switch region; other site 311403004879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004880 dimer interface [polypeptide binding]; other site 311403004881 conserved gate region; other site 311403004882 ABC-ATPase subunit interface; other site 311403004883 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403004884 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403004885 Flavin binding site [chemical binding]; other site 311403004886 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403004887 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403004888 active site 311403004889 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403004890 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403004891 active site 311403004892 non-prolyl cis peptide bond; other site 311403004893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403004894 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403004895 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 311403004896 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 311403004897 conserved cys residue [active] 311403004898 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 311403004899 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 311403004900 conserved cys residue [active] 311403004901 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 311403004902 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 311403004903 nucleotide binding site [chemical binding]; other site 311403004904 SulA interaction site; other site 311403004905 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 311403004906 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 311403004907 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403004908 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 311403004909 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 311403004910 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 311403004911 [4Fe-4S] binding site [ion binding]; other site 311403004912 molybdopterin cofactor binding site; other site 311403004913 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 311403004914 molybdopterin cofactor binding site; other site 311403004915 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 311403004916 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 311403004917 [2Fe-2S] cluster binding site [ion binding]; other site 311403004918 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 311403004919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403004920 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 311403004921 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 311403004922 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 311403004923 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403004924 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403004925 Walker A/P-loop; other site 311403004926 ATP binding site [chemical binding]; other site 311403004927 Q-loop/lid; other site 311403004928 ABC transporter signature motif; other site 311403004929 Walker B; other site 311403004930 D-loop; other site 311403004931 H-loop/switch region; other site 311403004932 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403004933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403004934 putative PBP binding loops; other site 311403004935 dimer interface [polypeptide binding]; other site 311403004936 ABC-ATPase subunit interface; other site 311403004937 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403004938 NMT1-like family; Region: NMT1_2; pfam13379 311403004939 NMT1-like family; Region: NMT1_2; pfam13379 311403004940 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403004941 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 311403004942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403004943 active site 311403004944 phosphorylation site [posttranslational modification] 311403004945 intermolecular recognition site; other site 311403004946 ANTAR domain; Region: ANTAR; pfam03861 311403004947 heat shock protein 90; Provisional; Region: PRK05218 311403004948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403004949 ATP binding site [chemical binding]; other site 311403004950 Mg2+ binding site [ion binding]; other site 311403004951 G-X-G motif; other site 311403004952 Tannase and feruloyl esterase; Region: Tannase; pfam07519 311403004953 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403004954 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 311403004955 putative NAD(P) binding site [chemical binding]; other site 311403004956 Zinc-binding dehydrogenase; Region: ADH_zinc_N; pfam00107 311403004957 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403004958 MarR family; Region: MarR_2; pfam12802 311403004959 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 311403004960 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 311403004961 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 311403004962 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 311403004963 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 311403004964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403004965 FeS/SAM binding site; other site 311403004966 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 311403004967 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 311403004968 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 311403004969 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 311403004970 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 311403004971 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 311403004972 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 311403004973 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403004974 ABC-ATPase subunit interface; other site 311403004975 dimer interface [polypeptide binding]; other site 311403004976 putative PBP binding regions; other site 311403004977 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 311403004978 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 311403004979 putative ligand binding residues [chemical binding]; other site 311403004980 Ketopantoate hydroxymethyltransferase [Coenzyme metabolism]; Region: PanB; COG0413 311403004981 active site 311403004982 metal binding site [ion binding]; metal-binding site 311403004983 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 311403004984 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 311403004985 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 311403004986 putative active site [active] 311403004987 putative substrate binding site [chemical binding]; other site 311403004988 putative cosubstrate binding site; other site 311403004989 catalytic site [active] 311403004990 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 311403004991 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 311403004992 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 311403004993 homodimer interface [polypeptide binding]; other site 311403004994 NADP binding site [chemical binding]; other site 311403004995 substrate binding site [chemical binding]; other site 311403004996 Porin subfamily; Region: Porin_2; pfam02530 311403004997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403004998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403004999 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 311403005000 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 311403005001 active site 311403005002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005004 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 311403005005 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403005006 dimerization interface [polypeptide binding]; other site 311403005007 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 311403005008 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 311403005009 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 311403005010 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 311403005011 ring oligomerisation interface [polypeptide binding]; other site 311403005012 ATP/Mg binding site [chemical binding]; other site 311403005013 stacking interactions; other site 311403005014 hinge regions; other site 311403005015 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 311403005016 oligomerisation interface [polypeptide binding]; other site 311403005017 mobile loop; other site 311403005018 roof hairpin; other site 311403005019 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 311403005020 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 311403005021 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403005022 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 311403005023 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403005024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403005025 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403005026 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403005027 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 311403005028 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 311403005029 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 311403005030 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 311403005031 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 311403005032 Walker A motif; other site 311403005033 ATP binding site [chemical binding]; other site 311403005034 Walker B motif; other site 311403005035 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 311403005036 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 311403005037 type III secretion system protein YscR; Provisional; Region: PRK12797 311403005038 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 311403005039 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; pfam01312 311403005040 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 311403005041 FHIPEP family; Region: FHIPEP; pfam00771 311403005042 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 311403005043 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 311403005044 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 311403005045 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 311403005046 HflK protein; Region: hflK; TIGR01933 311403005047 HflC protein; Region: hflC; TIGR01932 311403005048 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 311403005049 HflK protein; Region: hflK; TIGR01933 311403005050 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 311403005051 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403005052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005053 DNA-binding site [nucleotide binding]; DNA binding site 311403005054 FCD domain; Region: FCD; pfam07729 311403005055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 311403005056 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 311403005057 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005058 Walker A/P-loop; other site 311403005059 ATP binding site [chemical binding]; other site 311403005060 Q-loop/lid; other site 311403005061 ABC transporter signature motif; other site 311403005062 Walker B; other site 311403005063 D-loop; other site 311403005064 H-loop/switch region; other site 311403005065 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403005066 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403005067 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005068 Walker A/P-loop; other site 311403005069 ATP binding site [chemical binding]; other site 311403005070 Q-loop/lid; other site 311403005071 ABC transporter signature motif; other site 311403005072 Walker B; other site 311403005073 D-loop; other site 311403005074 H-loop/switch region; other site 311403005075 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403005077 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403005078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005079 dimer interface [polypeptide binding]; other site 311403005080 conserved gate region; other site 311403005081 putative PBP binding loops; other site 311403005082 ABC-ATPase subunit interface; other site 311403005083 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403005084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005085 dimer interface [polypeptide binding]; other site 311403005086 conserved gate region; other site 311403005087 putative PBP binding loops; other site 311403005088 ABC-ATPase subunit interface; other site 311403005089 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 311403005090 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 311403005091 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403005092 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403005093 inhibitor site; inhibition site 311403005094 active site 311403005095 dimer interface [polypeptide binding]; other site 311403005096 catalytic residue [active] 311403005097 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 311403005098 BNR repeat-like domain; Region: BNR_2; pfam13088 311403005099 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 311403005100 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 311403005101 active site 311403005102 NAD binding site [chemical binding]; other site 311403005103 metal binding site [ion binding]; metal-binding site 311403005104 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 311403005105 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 311403005106 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403005107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005108 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403005109 dimerization interface [polypeptide binding]; other site 311403005110 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 311403005111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 311403005112 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 311403005113 FAD binding domain; Region: FAD_binding_4; pfam01565 311403005114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403005115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005116 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 311403005117 putative dimerization interface [polypeptide binding]; other site 311403005118 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403005119 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 311403005120 ligand binding site [chemical binding]; other site 311403005121 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403005122 TM-ABC transporter signature motif; other site 311403005123 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403005124 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403005125 TM-ABC transporter signature motif; other site 311403005126 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403005127 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403005128 Walker A/P-loop; other site 311403005129 ATP binding site [chemical binding]; other site 311403005130 Q-loop/lid; other site 311403005131 ABC transporter signature motif; other site 311403005132 Walker B; other site 311403005133 D-loop; other site 311403005134 H-loop/switch region; other site 311403005135 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403005136 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403005137 Walker A/P-loop; other site 311403005138 ATP binding site [chemical binding]; other site 311403005139 Q-loop/lid; other site 311403005140 ABC transporter signature motif; other site 311403005141 Walker B; other site 311403005142 D-loop; other site 311403005143 H-loop/switch region; other site 311403005144 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 311403005145 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 311403005146 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 311403005147 NAD(P) binding site [chemical binding]; other site 311403005148 shikimate binding site; other site 311403005149 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403005150 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 311403005151 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 311403005152 dimer interface [polypeptide binding]; other site 311403005153 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 311403005154 active site 311403005155 Fe binding site [ion binding]; other site 311403005156 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 311403005157 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 311403005158 putative ligand binding residues [chemical binding]; other site 311403005159 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 311403005160 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 311403005161 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403005162 ABC-ATPase subunit interface; other site 311403005163 dimer interface [polypeptide binding]; other site 311403005164 putative PBP binding regions; other site 311403005165 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 311403005166 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 311403005167 Walker A/P-loop; other site 311403005168 ATP binding site [chemical binding]; other site 311403005169 Q-loop/lid; other site 311403005170 ABC transporter signature motif; other site 311403005171 Walker B; other site 311403005172 D-loop; other site 311403005173 H-loop/switch region; other site 311403005174 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 311403005175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403005176 S-adenosylmethionine binding site [chemical binding]; other site 311403005177 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 311403005178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005179 DNA-binding site [nucleotide binding]; DNA binding site 311403005180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403005181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403005182 homodimer interface [polypeptide binding]; other site 311403005183 catalytic residue [active] 311403005184 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403005185 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403005186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403005187 substrate binding pocket [chemical binding]; other site 311403005188 membrane-bound complex binding site; other site 311403005189 hinge residues; other site 311403005190 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403005191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005192 dimer interface [polypeptide binding]; other site 311403005193 conserved gate region; other site 311403005194 putative PBP binding loops; other site 311403005195 ABC-ATPase subunit interface; other site 311403005196 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403005197 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403005198 Walker A/P-loop; other site 311403005199 ATP binding site [chemical binding]; other site 311403005200 Q-loop/lid; other site 311403005201 ABC transporter signature motif; other site 311403005202 Walker B; other site 311403005203 D-loop; other site 311403005204 H-loop/switch region; other site 311403005205 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005206 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403005207 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 311403005208 metal binding site [ion binding]; metal-binding site 311403005209 putative dimer interface [polypeptide binding]; other site 311403005210 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403005211 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403005212 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403005213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005214 DNA-binding site [nucleotide binding]; DNA binding site 311403005215 FCD domain; Region: FCD; pfam07729 311403005216 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 311403005217 malonyl-CoA synthase; Validated; Region: PRK07514 311403005218 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 311403005219 acyl-activating enzyme (AAE) consensus motif; other site 311403005220 active site 311403005221 AMP binding site [chemical binding]; other site 311403005222 CoA binding site [chemical binding]; other site 311403005223 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 311403005224 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 311403005225 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 311403005226 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 311403005227 putative DNA binding site [nucleotide binding]; other site 311403005228 putative Zn2+ binding site [ion binding]; other site 311403005229 AsnC family; Region: AsnC_trans_reg; pfam01037 311403005230 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 311403005231 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 311403005232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403005233 catalytic residue [active] 311403005234 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403005235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005236 DNA-binding site [nucleotide binding]; DNA binding site 311403005237 FCD domain; Region: FCD; pfam07729 311403005238 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 311403005239 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403005240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403005241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005242 dimer interface [polypeptide binding]; other site 311403005243 conserved gate region; other site 311403005244 putative PBP binding loops; other site 311403005245 ABC-ATPase subunit interface; other site 311403005246 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403005247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005248 dimer interface [polypeptide binding]; other site 311403005249 conserved gate region; other site 311403005250 putative PBP binding loops; other site 311403005251 ABC-ATPase subunit interface; other site 311403005252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005253 ABC transporter; Region: ABC_tran; pfam00005 311403005254 Q-loop/lid; other site 311403005255 ABC transporter signature motif; other site 311403005256 Walker B; other site 311403005257 D-loop; other site 311403005258 H-loop/switch region; other site 311403005259 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005260 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403005261 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005262 Walker A/P-loop; other site 311403005263 ATP binding site [chemical binding]; other site 311403005264 Q-loop/lid; other site 311403005265 ABC transporter signature motif; other site 311403005266 Walker B; other site 311403005267 D-loop; other site 311403005268 H-loop/switch region; other site 311403005269 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005270 hypothetical protein; Provisional; Region: PRK07079 311403005271 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 311403005272 metal binding site [ion binding]; metal-binding site 311403005273 putative dimer interface [polypeptide binding]; other site 311403005274 amidase; Provisional; Region: PRK07486 311403005275 Amidase; Region: Amidase; pfam01425 311403005276 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 311403005277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403005278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005279 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403005280 putative effector binding pocket; other site 311403005281 dimerization interface [polypeptide binding]; other site 311403005282 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403005283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005284 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403005285 dimerization interface [polypeptide binding]; other site 311403005286 substrate binding pocket [chemical binding]; other site 311403005287 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 311403005288 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403005289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005290 DNA-binding site [nucleotide binding]; DNA binding site 311403005291 FCD domain; Region: FCD; pfam07729 311403005292 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 311403005293 Aspartase; Region: Aspartase; cd01357 311403005294 active sites [active] 311403005295 tetramer interface [polypeptide binding]; other site 311403005296 L-asparagine permease; Provisional; Region: PRK15049 311403005297 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 311403005298 active site 311403005299 homotetramer interface [polypeptide binding]; other site 311403005300 homodimer interface [polypeptide binding]; other site 311403005301 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 311403005302 Amidinotransferase; Region: Amidinotransf; cl12043 311403005303 mechanosensitive channel MscS; Provisional; Region: PRK10334 311403005304 Conserved TM helix; Region: TM_helix; pfam05552 311403005305 Mechanosensitive ion channel; Region: MS_channel; pfam00924 311403005306 septum formation inhibitor; Reviewed; Region: minC; PRK05177 311403005307 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 311403005308 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 311403005309 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 311403005310 Switch I; other site 311403005311 Switch II; other site 311403005312 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 311403005313 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 311403005314 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403005315 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 311403005316 Walker A/P-loop; other site 311403005317 ATP binding site [chemical binding]; other site 311403005318 Q-loop/lid; other site 311403005319 ABC transporter signature motif; other site 311403005320 Walker B; other site 311403005321 D-loop; other site 311403005322 H-loop/switch region; other site 311403005323 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 311403005324 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 311403005325 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403005326 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 311403005327 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 311403005328 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 311403005329 active site 311403005330 catalytic residues [active] 311403005331 FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566 311403005332 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403005333 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 311403005334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403005335 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 311403005336 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 311403005337 dimer interface [polypeptide binding]; other site 311403005338 decamer (pentamer of dimers) interface [polypeptide binding]; other site 311403005339 catalytic triad [active] 311403005340 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403005341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403005343 dimerization interface [polypeptide binding]; other site 311403005344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403005345 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403005346 active site 311403005347 catalytic tetrad [active] 311403005348 Peptidase C26; Region: Peptidase_C26; pfam07722 311403005349 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 311403005350 catalytic triad [active] 311403005351 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403005352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403005353 substrate binding pocket [chemical binding]; other site 311403005354 membrane-bound complex binding site; other site 311403005355 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 311403005356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403005357 Walker A/P-loop; other site 311403005358 ATP binding site [chemical binding]; other site 311403005359 Q-loop/lid; other site 311403005360 ABC transporter signature motif; other site 311403005361 Walker B; other site 311403005362 D-loop; other site 311403005363 H-loop/switch region; other site 311403005364 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403005365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005366 dimer interface [polypeptide binding]; other site 311403005367 conserved gate region; other site 311403005368 putative PBP binding loops; other site 311403005369 ABC-ATPase subunit interface; other site 311403005370 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403005371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005372 dimer interface [polypeptide binding]; other site 311403005373 conserved gate region; other site 311403005374 putative PBP binding loops; other site 311403005375 ABC-ATPase subunit interface; other site 311403005376 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 311403005377 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403005378 putative metal binding site [ion binding]; other site 311403005379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005380 DNA-binding site [nucleotide binding]; DNA binding site 311403005381 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 311403005382 FCD domain; Region: FCD; pfam07729 311403005383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403005384 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403005385 active site 311403005386 catalytic tetrad [active] 311403005387 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403005388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005389 DNA-binding site [nucleotide binding]; DNA binding site 311403005390 FCD domain; Region: FCD; pfam07729 311403005391 mannonate dehydratase; Provisional; Region: PRK03906 311403005392 mannonate dehydratase; Region: uxuA; TIGR00695 311403005393 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 311403005394 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 311403005395 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 311403005396 putative oxidoreductase; Provisional; Region: PRK10083 311403005397 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 311403005398 putative NAD(P) binding site [chemical binding]; other site 311403005399 catalytic Zn binding site [ion binding]; other site 311403005400 structural Zn binding site [ion binding]; other site 311403005401 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403005402 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403005403 substrate binding pocket [chemical binding]; other site 311403005404 membrane-bound complex binding site; other site 311403005405 hinge residues; other site 311403005406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005407 dimer interface [polypeptide binding]; other site 311403005408 conserved gate region; other site 311403005409 ABC-ATPase subunit interface; other site 311403005410 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403005411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005412 dimer interface [polypeptide binding]; other site 311403005413 conserved gate region; other site 311403005414 putative PBP binding loops; other site 311403005415 ABC-ATPase subunit interface; other site 311403005416 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403005417 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403005418 Walker A/P-loop; other site 311403005419 ATP binding site [chemical binding]; other site 311403005420 Q-loop/lid; other site 311403005421 ABC transporter signature motif; other site 311403005422 Walker B; other site 311403005423 D-loop; other site 311403005424 H-loop/switch region; other site 311403005425 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403005426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005427 DNA-binding site [nucleotide binding]; DNA binding site 311403005428 FCD domain; Region: FCD; pfam07729 311403005429 recombination regulator RecX; Reviewed; Region: recX; PRK00117 311403005430 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 311403005431 Domain of unknown function (DUF336); Region: DUF336; cl01249 311403005432 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403005433 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403005434 DNA binding site [nucleotide binding] 311403005435 domain linker motif; other site 311403005436 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403005437 ligand binding site [chemical binding]; other site 311403005438 dimerization interface [polypeptide binding]; other site 311403005439 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403005440 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 311403005441 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403005442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005443 Walker A/P-loop; other site 311403005444 ATP binding site [chemical binding]; other site 311403005445 Q-loop/lid; other site 311403005446 ABC transporter signature motif; other site 311403005447 Walker B; other site 311403005448 D-loop; other site 311403005449 H-loop/switch region; other site 311403005450 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005451 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403005452 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005453 Walker A/P-loop; other site 311403005454 ATP binding site [chemical binding]; other site 311403005455 Q-loop/lid; other site 311403005456 ABC transporter signature motif; other site 311403005457 Walker B; other site 311403005458 D-loop; other site 311403005459 H-loop/switch region; other site 311403005460 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005461 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403005462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005463 dimer interface [polypeptide binding]; other site 311403005464 conserved gate region; other site 311403005465 putative PBP binding loops; other site 311403005466 ABC-ATPase subunit interface; other site 311403005467 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403005468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005469 dimer interface [polypeptide binding]; other site 311403005470 conserved gate region; other site 311403005471 putative PBP binding loops; other site 311403005472 ABC-ATPase subunit interface; other site 311403005473 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 311403005474 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 311403005475 active site 311403005476 catalytic site [active] 311403005477 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403005478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005479 DNA-binding site [nucleotide binding]; DNA binding site 311403005480 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403005481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005482 dimer interface [polypeptide binding]; other site 311403005483 conserved gate region; other site 311403005484 putative PBP binding loops; other site 311403005485 ABC-ATPase subunit interface; other site 311403005486 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403005487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005488 dimer interface [polypeptide binding]; other site 311403005489 conserved gate region; other site 311403005490 putative PBP binding loops; other site 311403005491 ABC-ATPase subunit interface; other site 311403005492 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 311403005493 classical (c) SDRs; Region: SDR_c; cd05233 311403005494 NAD(P) binding site [chemical binding]; other site 311403005495 active site 311403005496 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 311403005497 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 311403005498 active site 311403005499 catalytic site [active] 311403005500 Zn binding site [ion binding]; other site 311403005501 tetramer interface [polypeptide binding]; other site 311403005502 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 311403005503 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 311403005504 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 311403005505 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403005506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005507 Walker A/P-loop; other site 311403005508 ATP binding site [chemical binding]; other site 311403005509 Q-loop/lid; other site 311403005510 ABC transporter signature motif; other site 311403005511 Walker B; other site 311403005512 D-loop; other site 311403005513 H-loop/switch region; other site 311403005514 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005515 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 311403005516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005517 Walker A/P-loop; other site 311403005518 ATP binding site [chemical binding]; other site 311403005519 Q-loop/lid; other site 311403005520 ABC transporter signature motif; other site 311403005521 Walker B; other site 311403005522 D-loop; other site 311403005523 H-loop/switch region; other site 311403005524 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403005525 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403005526 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 311403005527 hypothetical protein; Validated; Region: PRK08245 311403005528 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 311403005529 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403005530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005531 putative PBP binding loops; other site 311403005532 dimer interface [polypeptide binding]; other site 311403005533 ABC-ATPase subunit interface; other site 311403005534 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403005535 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403005536 Walker A/P-loop; other site 311403005537 ATP binding site [chemical binding]; other site 311403005538 Q-loop/lid; other site 311403005539 ABC transporter signature motif; other site 311403005540 Walker B; other site 311403005541 D-loop; other site 311403005542 H-loop/switch region; other site 311403005543 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403005544 NMT1-like family; Region: NMT1_2; pfam13379 311403005545 substrate binding pocket [chemical binding]; other site 311403005546 membrane-bound complex binding site; other site 311403005547 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403005548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005549 DNA-binding site [nucleotide binding]; DNA binding site 311403005550 FCD domain; Region: FCD; pfam07729 311403005551 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 311403005552 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 311403005553 quinolinate synthetase; Provisional; Region: PRK09375 311403005554 L-aspartate oxidase; Provisional; Region: PRK07512 311403005555 L-aspartate oxidase; Provisional; Region: PRK06175 311403005556 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 311403005557 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 311403005558 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 311403005559 dimerization interface [polypeptide binding]; other site 311403005560 active site 311403005561 short chain dehydrogenase; Provisional; Region: PRK06125 311403005562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403005563 NAD(P) binding site [chemical binding]; other site 311403005564 active site 311403005565 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403005566 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403005567 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403005568 putative active site [active] 311403005569 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 311403005570 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 311403005571 hinge; other site 311403005572 active site 311403005573 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403005574 nucleotide binding site [chemical binding]; other site 311403005575 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: PRK12570 311403005576 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 311403005577 putative active site [active] 311403005578 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403005579 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 311403005580 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403005581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005582 dimer interface [polypeptide binding]; other site 311403005583 conserved gate region; other site 311403005584 putative PBP binding loops; other site 311403005585 ABC-ATPase subunit interface; other site 311403005586 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403005587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005588 dimer interface [polypeptide binding]; other site 311403005589 conserved gate region; other site 311403005590 putative PBP binding loops; other site 311403005591 ABC-ATPase subunit interface; other site 311403005592 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403005593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005594 Walker A/P-loop; other site 311403005595 ATP binding site [chemical binding]; other site 311403005596 Q-loop/lid; other site 311403005597 ABC transporter signature motif; other site 311403005598 Walker B; other site 311403005599 D-loop; other site 311403005600 H-loop/switch region; other site 311403005601 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005602 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403005603 Walker A/P-loop; other site 311403005604 ATP binding site [chemical binding]; other site 311403005605 Q-loop/lid; other site 311403005606 ABC transporter signature motif; other site 311403005607 Walker B; other site 311403005608 D-loop; other site 311403005609 H-loop/switch region; other site 311403005610 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403005611 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 311403005612 Beta-lactamase; Region: Beta-lactamase; pfam00144 311403005613 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 311403005614 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 311403005615 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403005616 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403005617 catalytic residue [active] 311403005618 Sporulation related domain; Region: SPOR; cl10051 311403005619 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 311403005620 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 311403005621 putative molybdopterin cofactor binding site [chemical binding]; other site 311403005622 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 311403005623 putative molybdopterin cofactor binding site; other site 311403005624 guanine deaminase; Region: guan_deamin; TIGR02967 311403005625 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403005626 active site 311403005627 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 311403005628 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 311403005629 hydrophobic ligand binding site; other site 311403005630 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403005631 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403005632 TM-ABC transporter signature motif; other site 311403005633 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403005634 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403005635 TM-ABC transporter signature motif; other site 311403005636 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 311403005637 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403005638 Walker A/P-loop; other site 311403005639 ATP binding site [chemical binding]; other site 311403005640 Q-loop/lid; other site 311403005641 ABC transporter signature motif; other site 311403005642 Walker B; other site 311403005643 D-loop; other site 311403005644 H-loop/switch region; other site 311403005645 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403005646 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 311403005647 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 311403005648 putative ligand binding site [chemical binding]; other site 311403005649 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 311403005650 iron-sulfur cluster [ion binding]; other site 311403005651 [2Fe-2S] cluster binding site [ion binding]; other site 311403005652 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 311403005653 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403005654 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 311403005655 N-terminal domain interface [polypeptide binding]; other site 311403005656 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 311403005657 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403005658 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403005659 active site 311403005660 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 311403005661 choline dehydrogenase; Validated; Region: PRK02106 311403005662 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403005663 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403005664 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403005665 Walker A/P-loop; other site 311403005666 ATP binding site [chemical binding]; other site 311403005667 Q-loop/lid; other site 311403005668 ABC transporter signature motif; other site 311403005669 Walker B; other site 311403005670 D-loop; other site 311403005671 H-loop/switch region; other site 311403005672 TOBE domain; Region: TOBE_2; pfam08402 311403005673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 311403005674 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 311403005675 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403005676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005677 dimer interface [polypeptide binding]; other site 311403005678 conserved gate region; other site 311403005679 putative PBP binding loops; other site 311403005680 ABC-ATPase subunit interface; other site 311403005681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005682 dimer interface [polypeptide binding]; other site 311403005683 conserved gate region; other site 311403005684 putative PBP binding loops; other site 311403005685 ABC-ATPase subunit interface; other site 311403005686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403005687 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403005688 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403005689 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403005690 DNA binding site [nucleotide binding] 311403005691 domain linker motif; other site 311403005692 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403005693 dimerization interface [polypeptide binding]; other site 311403005694 ligand binding site [chemical binding]; other site 311403005695 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 311403005696 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 311403005697 homodimer interface [polypeptide binding]; other site 311403005698 active site 311403005699 TDP-binding site; other site 311403005700 acceptor substrate-binding pocket; other site 311403005701 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 311403005702 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 311403005703 acyl-activating enzyme (AAE) consensus motif; other site 311403005704 AMP binding site [chemical binding]; other site 311403005705 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 311403005706 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 311403005707 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403005708 dimer interface [polypeptide binding]; other site 311403005709 phosphorylation site [posttranslational modification] 311403005710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403005711 ATP binding site [chemical binding]; other site 311403005712 G-X-G motif; other site 311403005713 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 311403005714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403005715 active site 311403005716 phosphorylation site [posttranslational modification] 311403005717 intermolecular recognition site; other site 311403005718 dimerization interface [polypeptide binding]; other site 311403005719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403005720 Walker A motif; other site 311403005721 ATP binding site [chemical binding]; other site 311403005722 Walker B motif; other site 311403005723 arginine finger; other site 311403005724 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403005725 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403005726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005727 dimer interface [polypeptide binding]; other site 311403005728 conserved gate region; other site 311403005729 putative PBP binding loops; other site 311403005730 ABC-ATPase subunit interface; other site 311403005731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005732 dimer interface [polypeptide binding]; other site 311403005733 conserved gate region; other site 311403005734 putative PBP binding loops; other site 311403005735 ABC-ATPase subunit interface; other site 311403005736 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403005737 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403005738 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403005739 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403005740 Walker A/P-loop; other site 311403005741 ATP binding site [chemical binding]; other site 311403005742 Q-loop/lid; other site 311403005743 ABC transporter signature motif; other site 311403005744 Walker B; other site 311403005745 D-loop; other site 311403005746 H-loop/switch region; other site 311403005747 TOBE domain; Region: TOBE_2; pfam08402 311403005748 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 311403005749 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403005750 substrate binding site [chemical binding]; other site 311403005751 ATP binding site [chemical binding]; other site 311403005752 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 311403005753 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 311403005754 putative active site; other site 311403005755 catalytic residue [active] 311403005756 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403005757 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403005758 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403005759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403005760 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403005761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403005762 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 311403005763 trimer interface [polypeptide binding]; other site 311403005764 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 311403005765 trimer interface [polypeptide binding]; other site 311403005766 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 311403005767 YadA-like C-terminal region; Region: YadA; pfam03895 311403005768 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 311403005769 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 311403005770 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 311403005771 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403005772 DNA-binding site [nucleotide binding]; DNA binding site 311403005773 RNA-binding motif; other site 311403005774 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 311403005775 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 311403005776 Walker A/P-loop; other site 311403005777 ATP binding site [chemical binding]; other site 311403005778 Q-loop/lid; other site 311403005779 ABC transporter signature motif; other site 311403005780 Walker B; other site 311403005781 D-loop; other site 311403005782 H-loop/switch region; other site 311403005783 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403005784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005785 dimer interface [polypeptide binding]; other site 311403005786 conserved gate region; other site 311403005787 putative PBP binding loops; other site 311403005788 ABC-ATPase subunit interface; other site 311403005789 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 311403005790 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 311403005791 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 311403005792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403005793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403005794 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 311403005795 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 311403005796 putative active site [active] 311403005797 putative FMN binding site [chemical binding]; other site 311403005798 putative substrate binding site [chemical binding]; other site 311403005799 putative catalytic residue [active] 311403005800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403005801 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 311403005802 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403005803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403005804 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403005805 putative effector binding pocket; other site 311403005806 putative dimerization interface [polypeptide binding]; other site 311403005807 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403005808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403005809 active site 311403005810 catalytic tetrad [active] 311403005811 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 311403005812 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403005813 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 311403005814 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403005815 catalytic site [active] 311403005816 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 311403005817 Predicted membrane protein [Function unknown]; Region: COG1238 311403005818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403005819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403005820 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 311403005821 classical (c) SDRs; Region: SDR_c; cd05233 311403005822 NAD(P) binding site [chemical binding]; other site 311403005823 active site 311403005824 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 311403005825 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 311403005826 FMN binding site [chemical binding]; other site 311403005827 active site 311403005828 substrate binding site [chemical binding]; other site 311403005829 catalytic residue [active] 311403005830 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 311403005831 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 311403005832 putative active site [active] 311403005833 putative NTP binding site [chemical binding]; other site 311403005834 putative nucleic acid binding site [nucleotide binding]; other site 311403005835 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 311403005836 DDE domain; Region: DDE_Tnp_IS240; pfam13610 311403005837 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403005838 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403005839 ligand binding site [chemical binding]; other site 311403005840 flexible hinge region; other site 311403005841 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 311403005842 non-specific DNA interactions [nucleotide binding]; other site 311403005843 DNA binding site [nucleotide binding] 311403005844 sequence specific DNA binding site [nucleotide binding]; other site 311403005845 putative cAMP binding site [chemical binding]; other site 311403005846 SAM domain (Sterile alpha motif); Region: SAM_2; pfam07647 311403005847 SAM (Sterile alpha motif ); Region: SAM_superfamily; cd09487 311403005848 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403005849 cyclase homology domain; Region: CHD; cd07302 311403005850 nucleotidyl binding site; other site 311403005851 metal binding site [ion binding]; metal-binding site 311403005852 dimer interface [polypeptide binding]; other site 311403005853 AAA ATPase domain; Region: AAA_16; pfam13191 311403005854 AAA domain; Region: AAA_22; pfam13401 311403005855 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 311403005856 FAD binding domain; Region: FAD_binding_4; pfam01565 311403005857 Berberine and berberine like; Region: BBE; pfam08031 311403005858 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 311403005859 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403005860 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 311403005861 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 311403005862 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 311403005863 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 311403005864 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403005865 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403005866 Walker A/P-loop; other site 311403005867 ATP binding site [chemical binding]; other site 311403005868 Q-loop/lid; other site 311403005869 ABC transporter signature motif; other site 311403005870 Walker B; other site 311403005871 D-loop; other site 311403005872 H-loop/switch region; other site 311403005873 TOBE domain; Region: TOBE_2; pfam08402 311403005874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403005875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005876 dimer interface [polypeptide binding]; other site 311403005877 conserved gate region; other site 311403005878 putative PBP binding loops; other site 311403005879 ABC-ATPase subunit interface; other site 311403005880 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 311403005881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005882 putative PBP binding loops; other site 311403005883 dimer interface [polypeptide binding]; other site 311403005884 ABC-ATPase subunit interface; other site 311403005885 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 311403005886 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403005887 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403005888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403005889 putative DNA binding site [nucleotide binding]; other site 311403005890 putative Zn2+ binding site [ion binding]; other site 311403005891 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403005892 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403005893 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 311403005894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 311403005895 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 311403005896 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 311403005897 Trp docking motif [polypeptide binding]; other site 311403005898 putative active site [active] 311403005899 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403005900 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403005901 Flavin binding site [chemical binding]; other site 311403005902 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403005903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403005904 active site 311403005905 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 311403005906 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403005907 putative ligand binding site [chemical binding]; other site 311403005908 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403005909 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403005910 Walker A/P-loop; other site 311403005911 ATP binding site [chemical binding]; other site 311403005912 Q-loop/lid; other site 311403005913 ABC transporter signature motif; other site 311403005914 Walker B; other site 311403005915 D-loop; other site 311403005916 H-loop/switch region; other site 311403005917 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403005918 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403005919 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403005920 TM-ABC transporter signature motif; other site 311403005921 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403005922 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403005923 active site 311403005924 non-prolyl cis peptide bond; other site 311403005925 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403005926 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403005927 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 311403005928 active site 311403005929 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403005930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403005931 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403005932 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403005933 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403005934 substrate binding pocket [chemical binding]; other site 311403005935 membrane-bound complex binding site; other site 311403005936 hinge residues; other site 311403005937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403005938 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403005939 substrate binding pocket [chemical binding]; other site 311403005940 membrane-bound complex binding site; other site 311403005941 hinge residues; other site 311403005942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005943 dimer interface [polypeptide binding]; other site 311403005944 conserved gate region; other site 311403005945 putative PBP binding loops; other site 311403005946 ABC-ATPase subunit interface; other site 311403005947 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403005948 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403005949 Walker A/P-loop; other site 311403005950 ATP binding site [chemical binding]; other site 311403005951 Q-loop/lid; other site 311403005952 ABC transporter signature motif; other site 311403005953 Walker B; other site 311403005954 D-loop; other site 311403005955 H-loop/switch region; other site 311403005956 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403005957 Coenzyme A binding pocket [chemical binding]; other site 311403005958 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403005959 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 311403005960 metal binding site [ion binding]; metal-binding site 311403005961 putative dimer interface [polypeptide binding]; other site 311403005962 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403005963 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403005964 active site 311403005965 non-prolyl cis peptide bond; other site 311403005966 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 311403005967 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 311403005968 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403005969 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 311403005970 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403005971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005972 dimer interface [polypeptide binding]; other site 311403005973 conserved gate region; other site 311403005974 putative PBP binding loops; other site 311403005975 ABC-ATPase subunit interface; other site 311403005976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403005977 dimer interface [polypeptide binding]; other site 311403005978 conserved gate region; other site 311403005979 putative PBP binding loops; other site 311403005980 ABC-ATPase subunit interface; other site 311403005981 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403005982 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403005983 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403005984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403005985 Walker A/P-loop; other site 311403005986 ATP binding site [chemical binding]; other site 311403005987 Q-loop/lid; other site 311403005988 ABC transporter signature motif; other site 311403005989 Walker B; other site 311403005990 D-loop; other site 311403005991 H-loop/switch region; other site 311403005992 TOBE domain; Region: TOBE_2; pfam08402 311403005993 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403005994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403005995 DNA-binding site [nucleotide binding]; DNA binding site 311403005996 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 311403005997 cytosine deaminase; Provisional; Region: PRK05985 311403005998 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 311403005999 active site 311403006000 cytosine deaminase; Provisional; Region: PRK05985 311403006001 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 311403006002 active site 311403006003 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 311403006004 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403006005 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403006006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403006007 DNA-binding site [nucleotide binding]; DNA binding site 311403006008 FCD domain; Region: FCD; pfam07729 311403006009 hypothetical protein; Provisional; Region: PRK05968 311403006010 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 311403006011 homodimer interface [polypeptide binding]; other site 311403006012 substrate-cofactor binding pocket; other site 311403006013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403006014 catalytic residue [active] 311403006015 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403006016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403006017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006018 dimer interface [polypeptide binding]; other site 311403006019 conserved gate region; other site 311403006020 putative PBP binding loops; other site 311403006021 ABC-ATPase subunit interface; other site 311403006022 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403006023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006024 dimer interface [polypeptide binding]; other site 311403006025 conserved gate region; other site 311403006026 putative PBP binding loops; other site 311403006027 ABC-ATPase subunit interface; other site 311403006028 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403006029 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403006030 Walker A/P-loop; other site 311403006031 ATP binding site [chemical binding]; other site 311403006032 Q-loop/lid; other site 311403006033 ABC transporter signature motif; other site 311403006034 Walker B; other site 311403006035 D-loop; other site 311403006036 H-loop/switch region; other site 311403006037 TOBE domain; Region: TOBE_2; pfam08402 311403006038 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403006039 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403006040 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 311403006041 active site 311403006042 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403006043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403006044 DNA-binding site [nucleotide binding]; DNA binding site 311403006045 FCD domain; Region: FCD; pfam07729 311403006046 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403006047 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403006048 inhibitor site; inhibition site 311403006049 active site 311403006050 dimer interface [polypeptide binding]; other site 311403006051 catalytic residue [active] 311403006052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 311403006053 Histidine kinase; Region: HisKA_3; pfam07730 311403006054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403006055 ATP binding site [chemical binding]; other site 311403006056 Mg2+ binding site [ion binding]; other site 311403006057 G-X-G motif; other site 311403006058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403006059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403006060 active site 311403006061 phosphorylation site [posttranslational modification] 311403006062 intermolecular recognition site; other site 311403006063 dimerization interface [polypeptide binding]; other site 311403006064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403006065 DNA binding residues [nucleotide binding] 311403006066 dimerization interface [polypeptide binding]; other site 311403006067 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 311403006068 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403006069 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403006070 Walker A/P-loop; other site 311403006071 ATP binding site [chemical binding]; other site 311403006072 Q-loop/lid; other site 311403006073 ABC transporter signature motif; other site 311403006074 Walker B; other site 311403006075 D-loop; other site 311403006076 H-loop/switch region; other site 311403006077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006078 dimer interface [polypeptide binding]; other site 311403006079 conserved gate region; other site 311403006080 putative PBP binding loops; other site 311403006081 ABC-ATPase subunit interface; other site 311403006082 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403006083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006084 dimer interface [polypeptide binding]; other site 311403006085 conserved gate region; other site 311403006086 putative PBP binding loops; other site 311403006087 ABC-ATPase subunit interface; other site 311403006088 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403006089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403006090 substrate binding pocket [chemical binding]; other site 311403006091 membrane-bound complex binding site; other site 311403006092 hinge residues; other site 311403006093 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 311403006094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403006095 DNA-binding site [nucleotide binding]; DNA binding site 311403006096 UTRA domain; Region: UTRA; pfam07702 311403006097 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403006098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403006099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403006100 dimerization interface [polypeptide binding]; other site 311403006101 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403006102 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403006103 active site 311403006104 non-prolyl cis peptide bond; other site 311403006105 hypothetical protein; Provisional; Region: PRK07550 311403006106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403006107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403006108 homodimer interface [polypeptide binding]; other site 311403006109 catalytic residue [active] 311403006110 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 311403006111 agmatinase; Region: agmatinase; TIGR01230 311403006112 oligomer interface [polypeptide binding]; other site 311403006113 putative active site [active] 311403006114 Mn binding site [ion binding]; other site 311403006115 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403006116 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403006117 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403006118 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 311403006119 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 311403006120 Walker A/P-loop; other site 311403006121 ATP binding site [chemical binding]; other site 311403006122 Q-loop/lid; other site 311403006123 ABC transporter signature motif; other site 311403006124 Walker B; other site 311403006125 D-loop; other site 311403006126 H-loop/switch region; other site 311403006127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 311403006128 FtsX-like permease family; Region: FtsX; pfam02687 311403006129 HAMP domain; Region: HAMP; pfam00672 311403006130 dimerization interface [polypeptide binding]; other site 311403006131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403006132 dimer interface [polypeptide binding]; other site 311403006133 phosphorylation site [posttranslational modification] 311403006134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403006135 ATP binding site [chemical binding]; other site 311403006136 Mg2+ binding site [ion binding]; other site 311403006137 G-X-G motif; other site 311403006138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403006139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403006140 active site 311403006141 phosphorylation site [posttranslational modification] 311403006142 intermolecular recognition site; other site 311403006143 dimerization interface [polypeptide binding]; other site 311403006144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403006145 DNA binding site [nucleotide binding] 311403006146 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 311403006147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006148 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 311403006149 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 311403006150 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 311403006151 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403006152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403006153 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 311403006154 Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177 311403006155 Walker A/P-loop; other site 311403006156 ATP binding site [chemical binding]; other site 311403006157 Q-loop/lid; other site 311403006158 ABC transporter signature motif; other site 311403006159 Walker B; other site 311403006160 D-loop; other site 311403006161 H-loop/switch region; other site 311403006162 Chain length determinant protein; Region: Wzz; cl15801 311403006163 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 311403006164 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 311403006165 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 311403006166 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 311403006167 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006168 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 311403006169 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 311403006170 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 311403006171 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 311403006172 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 311403006173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403006174 binding surface 311403006175 TPR motif; other site 311403006176 TPR repeat; Region: TPR_11; pfam13414 311403006177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403006178 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006179 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403006180 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006181 Hint domain; Region: Hint_2; pfam13403 311403006182 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 311403006183 Protein of unknown function (DUF982); Region: DUF982; pfam06169 311403006184 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 311403006185 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403006186 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403006187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403006188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403006189 non-specific DNA binding site [nucleotide binding]; other site 311403006190 salt bridge; other site 311403006191 sequence-specific DNA binding site [nucleotide binding]; other site 311403006192 Protein of unknown function (DUF992); Region: DUF992; pfam06186 311403006193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 311403006194 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403006195 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403006196 acetylornithine deacetylase; Provisional; Region: PRK07522 311403006197 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 311403006198 metal binding site [ion binding]; metal-binding site 311403006199 putative dimer interface [polypeptide binding]; other site 311403006200 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 311403006201 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 311403006202 putative ligand binding site [chemical binding]; other site 311403006203 NAD binding site [chemical binding]; other site 311403006204 dimerization interface [polypeptide binding]; other site 311403006205 catalytic site [active] 311403006206 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 311403006207 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 311403006208 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403006209 NAD(P) binding site [chemical binding]; other site 311403006210 catalytic residues [active] 311403006211 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 311403006212 tartrate dehydrogenase; Region: TTC; TIGR02089 311403006213 succinic semialdehyde dehydrogenase; Region: PLN02278 311403006214 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 311403006215 tetramerization interface [polypeptide binding]; other site 311403006216 NAD(P) binding site [chemical binding]; other site 311403006217 catalytic residues [active] 311403006218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403006219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403006220 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 311403006221 homotrimer interaction site [polypeptide binding]; other site 311403006222 putative active site [active] 311403006223 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403006224 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403006225 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 311403006226 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 311403006227 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 311403006228 hypothetical protein; Provisional; Region: PRK05965 311403006229 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403006230 inhibitor-cofactor binding pocket; inhibition site 311403006231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403006232 catalytic residue [active] 311403006233 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 311403006234 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 311403006235 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403006236 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 311403006237 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403006238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006239 dimer interface [polypeptide binding]; other site 311403006240 conserved gate region; other site 311403006241 putative PBP binding loops; other site 311403006242 ABC-ATPase subunit interface; other site 311403006243 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403006244 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403006245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006246 dimer interface [polypeptide binding]; other site 311403006247 conserved gate region; other site 311403006248 ABC-ATPase subunit interface; other site 311403006249 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403006250 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006251 Walker A/P-loop; other site 311403006252 ATP binding site [chemical binding]; other site 311403006253 Q-loop/lid; other site 311403006254 ABC transporter signature motif; other site 311403006255 Walker B; other site 311403006256 D-loop; other site 311403006257 H-loop/switch region; other site 311403006258 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403006259 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006260 Walker A/P-loop; other site 311403006261 ATP binding site [chemical binding]; other site 311403006262 Q-loop/lid; other site 311403006263 ABC transporter signature motif; other site 311403006264 Walker B; other site 311403006265 D-loop; other site 311403006266 H-loop/switch region; other site 311403006267 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403006268 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403006269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403006270 putative DNA binding site [nucleotide binding]; other site 311403006271 putative Zn2+ binding site [ion binding]; other site 311403006272 AsnC family; Region: AsnC_trans_reg; pfam01037 311403006273 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403006274 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403006275 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 311403006276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403006277 ABC-ATPase subunit interface; other site 311403006278 dimer interface [polypeptide binding]; other site 311403006279 putative PBP binding regions; other site 311403006280 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 311403006281 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 311403006282 Walker A/P-loop; other site 311403006283 ATP binding site [chemical binding]; other site 311403006284 Q-loop/lid; other site 311403006285 ABC transporter signature motif; other site 311403006286 Walker B; other site 311403006287 D-loop; other site 311403006288 H-loop/switch region; other site 311403006289 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 311403006290 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403006291 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 311403006292 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 311403006293 intersubunit interface [polypeptide binding]; other site 311403006294 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 311403006295 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 311403006296 N-terminal plug; other site 311403006297 ligand-binding site [chemical binding]; other site 311403006298 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403006299 Methyltransferase domain; Region: Methyltransf_24; pfam13578 311403006300 hypothetical protein; Provisional; Region: PRK07338 311403006301 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 311403006302 metal binding site [ion binding]; metal-binding site 311403006303 dimer interface [polypeptide binding]; other site 311403006304 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 311403006305 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403006306 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 311403006307 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 311403006308 active site 311403006309 catalytic site [active] 311403006310 Zn binding site [ion binding]; other site 311403006311 tetramer interface [polypeptide binding]; other site 311403006312 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403006313 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 311403006314 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403006315 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403006316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403006317 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403006318 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403006319 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 311403006320 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 311403006321 Walker A/P-loop; other site 311403006322 ATP binding site [chemical binding]; other site 311403006323 Q-loop/lid; other site 311403006324 ABC transporter signature motif; other site 311403006325 Walker B; other site 311403006326 D-loop; other site 311403006327 H-loop/switch region; other site 311403006328 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 311403006329 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 311403006330 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 311403006331 FtsX-like permease family; Region: FtsX; pfam02687 311403006332 FOG: CBS domain [General function prediction only]; Region: COG0517 311403006333 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 311403006334 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 311403006335 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 311403006336 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 311403006337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403006338 dimer interface [polypeptide binding]; other site 311403006339 phosphorylation site [posttranslational modification] 311403006340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403006341 ATP binding site [chemical binding]; other site 311403006342 Mg2+ binding site [ion binding]; other site 311403006343 G-X-G motif; other site 311403006344 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 311403006345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403006346 Walker A motif; other site 311403006347 ATP binding site [chemical binding]; other site 311403006348 Walker B motif; other site 311403006349 arginine finger; other site 311403006350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403006351 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 311403006352 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 311403006353 putative S-transferase; Provisional; Region: PRK11752 311403006354 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 311403006355 C-terminal domain interface [polypeptide binding]; other site 311403006356 GSH binding site (G-site) [chemical binding]; other site 311403006357 dimer interface [polypeptide binding]; other site 311403006358 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 311403006359 dimer interface [polypeptide binding]; other site 311403006360 N-terminal domain interface [polypeptide binding]; other site 311403006361 active site 311403006362 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 311403006363 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 311403006364 substrate binding site [chemical binding]; other site 311403006365 multimerization interface [polypeptide binding]; other site 311403006366 ATP binding site [chemical binding]; other site 311403006367 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 311403006368 thiamine phosphate binding site [chemical binding]; other site 311403006369 active site 311403006370 pyrophosphate binding site [ion binding]; other site 311403006371 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 311403006372 dimer interface [polypeptide binding]; other site 311403006373 substrate binding site [chemical binding]; other site 311403006374 ATP binding site [chemical binding]; other site 311403006375 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 311403006376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403006377 NAD(P) binding site [chemical binding]; other site 311403006378 active site 311403006379 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 311403006380 PhnA protein; Region: PhnA; pfam03831 311403006381 Bacitracin resistance protein BacA; Region: BacA; pfam02673 311403006382 transcriptional regulator NanR; Provisional; Region: PRK03837 311403006383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403006384 DNA-binding site [nucleotide binding]; DNA binding site 311403006385 FCD domain; Region: FCD; pfam07729 311403006386 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 311403006387 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 311403006388 dimer interface [polypeptide binding]; other site 311403006389 active site 311403006390 catalytic residue [active] 311403006391 metal binding site [ion binding]; metal-binding site 311403006392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 311403006393 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 311403006394 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403006395 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 311403006396 ligand binding site [chemical binding]; other site 311403006397 dimerization interface [polypeptide binding]; other site 311403006398 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 311403006399 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403006400 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403006401 Walker A/P-loop; other site 311403006402 ATP binding site [chemical binding]; other site 311403006403 Q-loop/lid; other site 311403006404 ABC transporter signature motif; other site 311403006405 Walker B; other site 311403006406 D-loop; other site 311403006407 H-loop/switch region; other site 311403006408 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403006409 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403006410 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403006411 TM-ABC transporter signature motif; other site 311403006412 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403006413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403006414 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403006415 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 311403006416 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 311403006417 DAK2 domain; Region: Dak2; cl03685 311403006418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403006419 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403006420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403006421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006422 dimer interface [polypeptide binding]; other site 311403006423 conserved gate region; other site 311403006424 putative PBP binding loops; other site 311403006425 ABC-ATPase subunit interface; other site 311403006426 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403006427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006428 dimer interface [polypeptide binding]; other site 311403006429 conserved gate region; other site 311403006430 putative PBP binding loops; other site 311403006431 ABC-ATPase subunit interface; other site 311403006432 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 311403006433 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403006434 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403006435 Walker A/P-loop; other site 311403006436 ATP binding site [chemical binding]; other site 311403006437 Q-loop/lid; other site 311403006438 ABC transporter signature motif; other site 311403006439 Walker B; other site 311403006440 D-loop; other site 311403006441 H-loop/switch region; other site 311403006442 TOBE domain; Region: TOBE; pfam03459 311403006443 DoxX-like family; Region: DoxX_2; pfam13564 311403006444 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403006445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006446 dimer interface [polypeptide binding]; other site 311403006447 conserved gate region; other site 311403006448 putative PBP binding loops; other site 311403006449 ABC-ATPase subunit interface; other site 311403006450 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403006451 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403006452 Walker A/P-loop; other site 311403006453 ATP binding site [chemical binding]; other site 311403006454 Q-loop/lid; other site 311403006455 ABC transporter signature motif; other site 311403006456 Walker B; other site 311403006457 D-loop; other site 311403006458 H-loop/switch region; other site 311403006459 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403006460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403006461 substrate binding pocket [chemical binding]; other site 311403006462 membrane-bound complex binding site; other site 311403006463 hinge residues; other site 311403006464 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403006465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403006466 DNA binding site [nucleotide binding] 311403006467 domain linker motif; other site 311403006468 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403006469 dimerization interface [polypeptide binding]; other site 311403006470 ligand binding site [chemical binding]; other site 311403006471 EamA-like transporter family; Region: EamA; pfam00892 311403006472 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 311403006473 EamA-like transporter family; Region: EamA; pfam00892 311403006474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403006475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403006476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403006477 dimerization interface [polypeptide binding]; other site 311403006478 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 311403006479 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 311403006480 conserved cys residue [active] 311403006481 Uncharacterized conserved protein [Function unknown]; Region: COG3246 311403006482 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 311403006483 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 311403006484 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 311403006485 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 311403006486 active site 311403006487 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403006488 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403006489 active site 311403006490 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 311403006491 CoA binding domain; Region: CoA_binding_2; pfam13380 311403006492 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 311403006493 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 311403006494 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 311403006495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403006496 substrate binding site [chemical binding]; other site 311403006497 trimer interface [polypeptide binding]; other site 311403006498 oxyanion hole (OAH) forming residues; other site 311403006499 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403006500 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 311403006501 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403006502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006503 dimer interface [polypeptide binding]; other site 311403006504 conserved gate region; other site 311403006505 putative PBP binding loops; other site 311403006506 ABC-ATPase subunit interface; other site 311403006507 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403006508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006509 dimer interface [polypeptide binding]; other site 311403006510 conserved gate region; other site 311403006511 ABC-ATPase subunit interface; other site 311403006512 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403006513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006514 Walker A/P-loop; other site 311403006515 ATP binding site [chemical binding]; other site 311403006516 Q-loop/lid; other site 311403006517 ABC transporter signature motif; other site 311403006518 Walker B; other site 311403006519 D-loop; other site 311403006520 H-loop/switch region; other site 311403006521 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403006522 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006523 Walker A/P-loop; other site 311403006524 ATP binding site [chemical binding]; other site 311403006525 Q-loop/lid; other site 311403006526 ABC transporter signature motif; other site 311403006527 Walker B; other site 311403006528 D-loop; other site 311403006529 H-loop/switch region; other site 311403006530 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403006531 non-specific DNA binding site [nucleotide binding]; other site 311403006532 salt bridge; other site 311403006533 Helix-turn-helix domain; Region: HTH_19; pfam12844 311403006534 sequence-specific DNA binding site [nucleotide binding]; other site 311403006535 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 311403006536 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403006537 Predicted acyl esterases [General function prediction only]; Region: COG2936 311403006538 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 311403006539 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 311403006540 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 311403006541 Protein of unknown function, DUF606; Region: DUF606; pfam04657 311403006542 Protein of unknown function, DUF606; Region: DUF606; pfam04657 311403006543 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403006544 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403006545 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 311403006546 putative effector binding pocket; other site 311403006547 putative dimerization interface [polypeptide binding]; other site 311403006548 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 311403006549 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 311403006550 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 311403006551 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403006552 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403006553 osmolarity response regulator; Provisional; Region: ompR; PRK09468 311403006554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403006555 active site 311403006556 phosphorylation site [posttranslational modification] 311403006557 intermolecular recognition site; other site 311403006558 dimerization interface [polypeptide binding]; other site 311403006559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403006560 DNA binding site [nucleotide binding] 311403006561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403006562 dimerization interface [polypeptide binding]; other site 311403006563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403006564 dimer interface [polypeptide binding]; other site 311403006565 phosphorylation site [posttranslational modification] 311403006566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403006567 ATP binding site [chemical binding]; other site 311403006568 Mg2+ binding site [ion binding]; other site 311403006569 G-X-G motif; other site 311403006570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403006571 S-adenosylmethionine binding site [chemical binding]; other site 311403006572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403006573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403006574 metal binding site [ion binding]; metal-binding site 311403006575 active site 311403006576 I-site; other site 311403006577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403006578 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 311403006579 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 311403006580 N-terminal plug; other site 311403006581 ligand-binding site [chemical binding]; other site 311403006582 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 311403006583 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 311403006584 Walker A/P-loop; other site 311403006585 ATP binding site [chemical binding]; other site 311403006586 Q-loop/lid; other site 311403006587 ABC transporter signature motif; other site 311403006588 Walker B; other site 311403006589 D-loop; other site 311403006590 H-loop/switch region; other site 311403006591 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 311403006592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403006593 putative PBP binding regions; other site 311403006594 ABC-ATPase subunit interface; other site 311403006595 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 311403006596 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403006597 ABC-ATPase subunit interface; other site 311403006598 dimer interface [polypeptide binding]; other site 311403006599 putative PBP binding regions; other site 311403006600 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 311403006601 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 311403006602 intersubunit interface [polypeptide binding]; other site 311403006603 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403006604 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403006605 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403006606 putative active site [active] 311403006607 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403006608 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403006609 substrate binding pocket [chemical binding]; other site 311403006610 membrane-bound complex binding site; other site 311403006611 hinge residues; other site 311403006612 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403006613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006614 dimer interface [polypeptide binding]; other site 311403006615 conserved gate region; other site 311403006616 putative PBP binding loops; other site 311403006617 ABC-ATPase subunit interface; other site 311403006618 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403006619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006620 dimer interface [polypeptide binding]; other site 311403006621 conserved gate region; other site 311403006622 putative PBP binding loops; other site 311403006623 ABC-ATPase subunit interface; other site 311403006624 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403006625 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403006626 Walker A/P-loop; other site 311403006627 ATP binding site [chemical binding]; other site 311403006628 Q-loop/lid; other site 311403006629 ABC transporter signature motif; other site 311403006630 Walker B; other site 311403006631 D-loop; other site 311403006632 H-loop/switch region; other site 311403006633 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 311403006634 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403006635 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403006636 active site 311403006637 non-prolyl cis peptide bond; other site 311403006638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403006639 D-galactonate transporter; Region: 2A0114; TIGR00893 311403006640 putative substrate translocation pore; other site 311403006641 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 311403006642 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 311403006643 active site 311403006644 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 311403006645 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 311403006646 active site 311403006647 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 311403006648 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403006649 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 311403006650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403006651 Walker A/P-loop; other site 311403006652 ATP binding site [chemical binding]; other site 311403006653 Q-loop/lid; other site 311403006654 ABC transporter signature motif; other site 311403006655 Walker B; other site 311403006656 D-loop; other site 311403006657 H-loop/switch region; other site 311403006658 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403006659 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 311403006660 NAD(P) binding site [chemical binding]; other site 311403006661 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403006662 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403006663 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403006664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006665 Walker A/P-loop; other site 311403006666 ATP binding site [chemical binding]; other site 311403006667 Q-loop/lid; other site 311403006668 ABC transporter signature motif; other site 311403006669 Walker B; other site 311403006670 D-loop; other site 311403006671 H-loop/switch region; other site 311403006672 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403006673 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006674 Walker A/P-loop; other site 311403006675 ATP binding site [chemical binding]; other site 311403006676 Q-loop/lid; other site 311403006677 ABC transporter signature motif; other site 311403006678 Walker B; other site 311403006679 D-loop; other site 311403006680 H-loop/switch region; other site 311403006681 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403006682 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403006683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006684 ABC-ATPase subunit interface; other site 311403006685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403006686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403006687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403006688 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 311403006689 KTSC domain; Region: KTSC; pfam13619 311403006690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403006691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403006692 putative substrate translocation pore; other site 311403006693 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 311403006694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403006695 Coenzyme A binding pocket [chemical binding]; other site 311403006696 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403006697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403006698 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403006699 EamA-like transporter family; Region: EamA; pfam00892 311403006700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403006701 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403006702 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 311403006703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006704 dimer interface [polypeptide binding]; other site 311403006705 conserved gate region; other site 311403006706 putative PBP binding loops; other site 311403006707 ABC-ATPase subunit interface; other site 311403006708 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403006709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006710 dimer interface [polypeptide binding]; other site 311403006711 conserved gate region; other site 311403006712 putative PBP binding loops; other site 311403006713 ABC-ATPase subunit interface; other site 311403006714 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403006715 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403006716 Walker A/P-loop; other site 311403006717 ATP binding site [chemical binding]; other site 311403006718 Q-loop/lid; other site 311403006719 ABC transporter signature motif; other site 311403006720 Walker B; other site 311403006721 D-loop; other site 311403006722 H-loop/switch region; other site 311403006723 TOBE domain; Region: TOBE_2; pfam08402 311403006724 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 311403006725 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 311403006726 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403006727 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 311403006728 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403006729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006730 dimer interface [polypeptide binding]; other site 311403006731 conserved gate region; other site 311403006732 putative PBP binding loops; other site 311403006733 ABC-ATPase subunit interface; other site 311403006734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403006735 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403006736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006737 dimer interface [polypeptide binding]; other site 311403006738 conserved gate region; other site 311403006739 putative PBP binding loops; other site 311403006740 ABC-ATPase subunit interface; other site 311403006741 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403006742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006743 Walker A/P-loop; other site 311403006744 ATP binding site [chemical binding]; other site 311403006745 Q-loop/lid; other site 311403006746 ABC transporter signature motif; other site 311403006747 Walker B; other site 311403006748 D-loop; other site 311403006749 H-loop/switch region; other site 311403006750 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403006751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403006752 Walker A/P-loop; other site 311403006753 ATP binding site [chemical binding]; other site 311403006754 Q-loop/lid; other site 311403006755 ABC transporter signature motif; other site 311403006756 Walker B; other site 311403006757 D-loop; other site 311403006758 H-loop/switch region; other site 311403006759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403006760 aminotransferase; Provisional; Region: PRK06105 311403006761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403006762 inhibitor-cofactor binding pocket; inhibition site 311403006763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403006764 catalytic residue [active] 311403006765 putative amidase; Provisional; Region: PRK06169 311403006766 Amidase; Region: Amidase; pfam01425 311403006767 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 311403006768 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 311403006769 active site 311403006770 ATP binding site [chemical binding]; other site 311403006771 substrate binding site [chemical binding]; other site 311403006772 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 311403006773 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403006774 inhibitor-cofactor binding pocket; inhibition site 311403006775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403006776 catalytic residue [active] 311403006777 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403006778 FCD domain; Region: FCD; pfam07729 311403006779 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403006780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006781 ABC-ATPase subunit interface; other site 311403006782 putative PBP binding loops; other site 311403006783 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403006784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403006785 dimer interface [polypeptide binding]; other site 311403006786 conserved gate region; other site 311403006787 putative PBP binding loops; other site 311403006788 ABC-ATPase subunit interface; other site 311403006789 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403006790 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 311403006791 peptide binding site [polypeptide binding]; other site 311403006792 dimer interface [polypeptide binding]; other site 311403006793 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 311403006794 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403006795 metal binding site [ion binding]; metal-binding site 311403006796 putative dimer interface [polypeptide binding]; other site 311403006797 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403006798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403006799 active site 311403006800 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 311403006801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403006802 NAD(P) binding site [chemical binding]; other site 311403006803 active site 311403006804 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 311403006805 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403006806 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403006807 Walker A/P-loop; other site 311403006808 ATP binding site [chemical binding]; other site 311403006809 Q-loop/lid; other site 311403006810 ABC transporter signature motif; other site 311403006811 Walker B; other site 311403006812 D-loop; other site 311403006813 H-loop/switch region; other site 311403006814 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403006815 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403006816 Walker A/P-loop; other site 311403006817 ATP binding site [chemical binding]; other site 311403006818 Q-loop/lid; other site 311403006819 ABC transporter signature motif; other site 311403006820 Walker B; other site 311403006821 D-loop; other site 311403006822 H-loop/switch region; other site 311403006823 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403006824 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403006825 TM-ABC transporter signature motif; other site 311403006826 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403006827 TM-ABC transporter signature motif; other site 311403006828 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 311403006829 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403006830 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 311403006831 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403006832 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403006833 classical (c) SDRs; Region: SDR_c; cd05233 311403006834 NAD(P) binding site [chemical binding]; other site 311403006835 active site 311403006836 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403006837 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403006838 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403006839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403006840 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403006841 dimerization interface [polypeptide binding]; other site 311403006842 substrate binding pocket [chemical binding]; other site 311403006843 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 311403006844 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 311403006845 TadE-like protein; Region: TadE; pfam07811 311403006846 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 311403006847 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 311403006848 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 311403006849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403006850 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 311403006851 dimerization interface [polypeptide binding]; other site 311403006852 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 311403006853 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 311403006854 dimer interface [polypeptide binding]; other site 311403006855 active site 311403006856 heme binding site [chemical binding]; other site 311403006857 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 311403006858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 311403006859 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006860 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403006861 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 311403006862 active site 311403006863 catalytic residues [active] 311403006864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006865 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 311403006866 putative ADP-binding pocket [chemical binding]; other site 311403006867 hypothetical protein; Provisional; Region: PRK07208 311403006868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403006869 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 311403006870 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 311403006871 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 311403006872 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 311403006873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 311403006874 active site 311403006875 Chain length determinant protein; Region: Wzz; cl15801 311403006876 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 311403006877 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 311403006878 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006879 Methyltransferase domain; Region: Methyltransf_23; pfam13489 311403006880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403006881 S-adenosylmethionine binding site [chemical binding]; other site 311403006882 Bacterial sugar transferase; Region: Bac_transf; pfam02397 311403006883 Homeodomain-like domain; Region: HTH_23; pfam13384 311403006884 Winged helix-turn helix; Region: HTH_29; pfam13551 311403006885 Homeodomain-like domain; Region: HTH_32; pfam13565 311403006886 DDE superfamily endonuclease; Region: DDE_3; pfam13358 311403006887 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 311403006888 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 311403006889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403006890 putative ADP-binding pocket [chemical binding]; other site 311403006891 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 311403006892 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 311403006893 SLBB domain; Region: SLBB; pfam10531 311403006894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 311403006895 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 311403006896 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403006897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403006898 non-specific DNA binding site [nucleotide binding]; other site 311403006899 salt bridge; other site 311403006900 sequence-specific DNA binding site [nucleotide binding]; other site 311403006901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403006902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 311403006903 dimer interface [polypeptide binding]; other site 311403006904 phosphorylation site [posttranslational modification] 311403006905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403006906 ATP binding site [chemical binding]; other site 311403006907 Mg2+ binding site [ion binding]; other site 311403006908 G-X-G motif; other site 311403006909 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403006910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403006911 active site 311403006912 phosphorylation site [posttranslational modification] 311403006913 intermolecular recognition site; other site 311403006914 dimerization interface [polypeptide binding]; other site 311403006915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403006916 DNA binding site [nucleotide binding] 311403006917 Peptidase propeptide and YPEB domain; Region: PepSY_2; cl17877 311403006918 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 311403006919 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 311403006920 acyl-activating enzyme (AAE) consensus motif; other site 311403006921 AMP binding site [chemical binding]; other site 311403006922 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 311403006923 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 311403006924 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 311403006925 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 311403006926 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 311403006927 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 311403006928 putative trimer interface [polypeptide binding]; other site 311403006929 putative CoA binding site [chemical binding]; other site 311403006930 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 311403006931 active site 311403006932 catalytic site [active] 311403006933 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 311403006934 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 311403006935 Sulfate transporter family; Region: Sulfate_transp; pfam00916 311403006936 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 311403006937 active site clefts [active] 311403006938 zinc binding site [ion binding]; other site 311403006939 dimer interface [polypeptide binding]; other site 311403006940 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403006941 DNA-binding site [nucleotide binding]; DNA binding site 311403006942 RNA-binding motif; other site 311403006943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403006944 Radical SAM superfamily; Region: Radical_SAM; pfam04055 311403006945 FeS/SAM binding site; other site 311403006946 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 311403006947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403006948 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 311403006949 putative dimerization interface [polypeptide binding]; other site 311403006950 putative substrate binding pocket [chemical binding]; other site 311403006951 Chromate transporter; Region: Chromate_transp; pfam02417 311403006952 Chromate transporter; Region: Chromate_transp; pfam02417 311403006953 Methyltransferase domain; Region: Methyltransf_24; pfam13578 311403006954 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403006955 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403006956 Metal-binding active site; metal-binding site 311403006957 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403006958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403006959 DNA binding site [nucleotide binding] 311403006960 domain linker motif; other site 311403006961 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403006962 ligand binding site [chemical binding]; other site 311403006963 dimerization interface [polypeptide binding]; other site 311403006964 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 311403006965 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403006966 ligand binding site [chemical binding]; other site 311403006967 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403006968 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403006969 Walker A/P-loop; other site 311403006970 ATP binding site [chemical binding]; other site 311403006971 Q-loop/lid; other site 311403006972 ABC transporter signature motif; other site 311403006973 Walker B; other site 311403006974 D-loop; other site 311403006975 H-loop/switch region; other site 311403006976 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403006977 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403006978 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403006979 TM-ABC transporter signature motif; other site 311403006980 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403006981 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403006982 TM-ABC transporter signature motif; other site 311403006983 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 311403006984 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 311403006985 N- and C-terminal domain interface [polypeptide binding]; other site 311403006986 putative active site [active] 311403006987 putative MgATP binding site [chemical binding]; other site 311403006988 putative catalytic site [active] 311403006989 metal binding site [ion binding]; metal-binding site 311403006990 putative carbohydrate binding site [chemical binding]; other site 311403006991 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 311403006992 intersubunit interface [polypeptide binding]; other site 311403006993 active site 311403006994 Zn2+ binding site [ion binding]; other site 311403006995 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403006996 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 311403006997 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403006998 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 311403006999 homotrimer interaction site [polypeptide binding]; other site 311403007000 putative active site [active] 311403007001 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403007002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403007003 Walker A/P-loop; other site 311403007004 ATP binding site [chemical binding]; other site 311403007005 Q-loop/lid; other site 311403007006 ABC transporter signature motif; other site 311403007007 Walker B; other site 311403007008 D-loop; other site 311403007009 H-loop/switch region; other site 311403007010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007011 dimer interface [polypeptide binding]; other site 311403007012 conserved gate region; other site 311403007013 putative PBP binding loops; other site 311403007014 ABC-ATPase subunit interface; other site 311403007015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007016 dimer interface [polypeptide binding]; other site 311403007017 conserved gate region; other site 311403007018 putative PBP binding loops; other site 311403007019 ABC-ATPase subunit interface; other site 311403007020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403007021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403007022 substrate binding pocket [chemical binding]; other site 311403007023 membrane-bound complex binding site; other site 311403007024 hinge residues; other site 311403007025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403007026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403007027 DNA binding site [nucleotide binding] 311403007028 domain linker motif; other site 311403007029 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 311403007030 putative dimerization interface [polypeptide binding]; other site 311403007031 putative ligand binding site [chemical binding]; other site 311403007032 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 311403007033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403007034 putative substrate translocation pore; other site 311403007035 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 311403007036 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 311403007037 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 311403007038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 311403007039 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 311403007040 intersubunit interface [polypeptide binding]; other site 311403007041 active site 311403007042 Zn2+ binding site [ion binding]; other site 311403007043 Response regulator receiver domain; Region: Response_reg; pfam00072 311403007044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403007045 active site 311403007046 phosphorylation site [posttranslational modification] 311403007047 intermolecular recognition site; other site 311403007048 dimerization interface [polypeptide binding]; other site 311403007049 CHASE3 domain; Region: CHASE3; pfam05227 311403007050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 311403007051 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 311403007052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403007053 putative active site [active] 311403007054 heme pocket [chemical binding]; other site 311403007055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403007056 dimer interface [polypeptide binding]; other site 311403007057 phosphorylation site [posttranslational modification] 311403007058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403007059 ATP binding site [chemical binding]; other site 311403007060 Mg2+ binding site [ion binding]; other site 311403007061 G-X-G motif; other site 311403007062 Response regulator receiver domain; Region: Response_reg; pfam00072 311403007063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403007064 active site 311403007065 phosphorylation site [posttranslational modification] 311403007066 intermolecular recognition site; other site 311403007067 dimerization interface [polypeptide binding]; other site 311403007068 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403007069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403007070 active site 311403007071 phosphorylation site [posttranslational modification] 311403007072 intermolecular recognition site; other site 311403007073 dimerization interface [polypeptide binding]; other site 311403007074 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403007075 DNA binding residues [nucleotide binding] 311403007076 dimerization interface [polypeptide binding]; other site 311403007077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 311403007078 Histidine kinase; Region: HisKA_3; pfam07730 311403007079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403007080 ATP binding site [chemical binding]; other site 311403007081 Mg2+ binding site [ion binding]; other site 311403007082 G-X-G motif; other site 311403007083 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 311403007084 SnoaL-like domain; Region: SnoaL_3; pfam13474 311403007085 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403007086 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007087 Walker A/P-loop; other site 311403007088 ATP binding site [chemical binding]; other site 311403007089 Q-loop/lid; other site 311403007090 ABC transporter signature motif; other site 311403007091 Walker B; other site 311403007092 D-loop; other site 311403007093 H-loop/switch region; other site 311403007094 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403007095 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403007096 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007097 Walker A/P-loop; other site 311403007098 ATP binding site [chemical binding]; other site 311403007099 Q-loop/lid; other site 311403007100 ABC transporter signature motif; other site 311403007101 Walker B; other site 311403007102 D-loop; other site 311403007103 H-loop/switch region; other site 311403007104 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403007105 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403007106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007107 dimer interface [polypeptide binding]; other site 311403007108 conserved gate region; other site 311403007109 putative PBP binding loops; other site 311403007110 ABC-ATPase subunit interface; other site 311403007111 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403007112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007113 dimer interface [polypeptide binding]; other site 311403007114 conserved gate region; other site 311403007115 putative PBP binding loops; other site 311403007116 ABC-ATPase subunit interface; other site 311403007117 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 311403007118 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 311403007119 substrate binding site [chemical binding]; other site 311403007120 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 311403007121 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 311403007122 Predicted transcriptional regulator [Transcription]; Region: COG4189 311403007123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403007124 dimerization interface [polypeptide binding]; other site 311403007125 putative DNA binding site [nucleotide binding]; other site 311403007126 putative Zn2+ binding site [ion binding]; other site 311403007127 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 311403007128 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 311403007129 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 311403007130 Soluble P-type ATPase [General function prediction only]; Region: COG4087 311403007131 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 311403007132 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 311403007133 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 311403007134 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 311403007135 Ligand Binding Site [chemical binding]; other site 311403007136 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 311403007137 GAF domain; Region: GAF_3; pfam13492 311403007138 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403007139 dimer interface [polypeptide binding]; other site 311403007140 phosphorylation site [posttranslational modification] 311403007141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403007142 ATP binding site [chemical binding]; other site 311403007143 Mg2+ binding site [ion binding]; other site 311403007144 G-X-G motif; other site 311403007145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403007146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403007147 active site 311403007148 phosphorylation site [posttranslational modification] 311403007149 intermolecular recognition site; other site 311403007150 dimerization interface [polypeptide binding]; other site 311403007151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403007152 DNA binding site [nucleotide binding] 311403007153 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 311403007154 active site 311403007155 phosphorylation site [posttranslational modification] 311403007156 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 311403007157 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403007158 substrate binding pocket [chemical binding]; other site 311403007159 membrane-bound complex binding site; other site 311403007160 hinge residues; other site 311403007161 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 311403007162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007163 dimer interface [polypeptide binding]; other site 311403007164 conserved gate region; other site 311403007165 putative PBP binding loops; other site 311403007166 ABC-ATPase subunit interface; other site 311403007167 sulfate transport protein; Provisional; Region: cysT; CHL00187 311403007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007169 dimer interface [polypeptide binding]; other site 311403007170 conserved gate region; other site 311403007171 putative PBP binding loops; other site 311403007172 ABC-ATPase subunit interface; other site 311403007173 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 311403007174 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 311403007175 Walker A/P-loop; other site 311403007176 ATP binding site [chemical binding]; other site 311403007177 Q-loop/lid; other site 311403007178 ABC transporter signature motif; other site 311403007179 Walker B; other site 311403007180 D-loop; other site 311403007181 H-loop/switch region; other site 311403007182 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403007183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403007184 NAD(P) binding site [chemical binding]; other site 311403007185 active site 311403007186 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403007187 catalytic core [active] 311403007188 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 311403007189 putative catalytic site [active] 311403007190 putative metal binding site [ion binding]; other site 311403007191 putative phosphate binding site [ion binding]; other site 311403007192 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 311403007193 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 311403007194 putative active site [active] 311403007195 catalytic site [active] 311403007196 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 311403007197 putative active site [active] 311403007198 catalytic site [active] 311403007199 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 311403007200 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 311403007201 glutathione s-transferase; Provisional; Region: PTZ00057 311403007202 GSH binding site (G-site) [chemical binding]; other site 311403007203 C-terminal domain interface [polypeptide binding]; other site 311403007204 dimer interface [polypeptide binding]; other site 311403007205 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 311403007206 dimer interface [polypeptide binding]; other site 311403007207 N-terminal domain interface [polypeptide binding]; other site 311403007208 substrate binding pocket (H-site) [chemical binding]; other site 311403007209 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 311403007210 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 311403007211 nucleotide binding site [chemical binding]; other site 311403007212 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403007213 classical (c) SDRs; Region: SDR_c; cd05233 311403007214 NAD(P) binding site [chemical binding]; other site 311403007215 active site 311403007216 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 311403007217 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 311403007218 dimer interface [polypeptide binding]; other site 311403007219 active site 311403007220 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 311403007221 Coenzyme A transferase; Region: CoA_trans; cl17247 311403007222 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 311403007223 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 311403007224 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403007225 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 311403007226 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403007227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403007228 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 311403007229 hypothetical protein; Provisional; Region: PRK07236 311403007230 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 311403007231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403007232 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403007233 dimerization interface [polypeptide binding]; other site 311403007234 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 311403007235 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 311403007236 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 311403007237 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 311403007238 heterodimer interface [polypeptide binding]; other site 311403007239 multimer interface [polypeptide binding]; other site 311403007240 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 311403007241 active site 311403007242 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 311403007243 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 311403007244 heterodimer interface [polypeptide binding]; other site 311403007245 active site 311403007246 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975 311403007247 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 311403007248 tetramer interface [polypeptide binding]; other site 311403007249 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 311403007250 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403007251 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403007252 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403007253 TM-ABC transporter signature motif; other site 311403007254 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403007255 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403007256 TM-ABC transporter signature motif; other site 311403007257 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403007258 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403007259 Walker A/P-loop; other site 311403007260 ATP binding site [chemical binding]; other site 311403007261 Q-loop/lid; other site 311403007262 ABC transporter signature motif; other site 311403007263 Walker B; other site 311403007264 D-loop; other site 311403007265 H-loop/switch region; other site 311403007266 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403007267 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403007268 Walker A/P-loop; other site 311403007269 ATP binding site [chemical binding]; other site 311403007270 Q-loop/lid; other site 311403007271 ABC transporter signature motif; other site 311403007272 Walker B; other site 311403007273 D-loop; other site 311403007274 H-loop/switch region; other site 311403007275 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 311403007276 oligomer interface [polypeptide binding]; other site 311403007277 active site 311403007278 Mn binding site [ion binding]; other site 311403007279 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403007280 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403007281 MarR family; Region: MarR_2; cl17246 311403007282 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 311403007283 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 311403007284 NodB motif; other site 311403007285 putative active site [active] 311403007286 putative catalytic site [active] 311403007287 putative Zn binding site [ion binding]; other site 311403007288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403007289 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403007290 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 311403007291 Iron-sulfur protein interface; other site 311403007292 proximal heme binding site [chemical binding]; other site 311403007293 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 311403007294 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403007295 catalytic loop [active] 311403007296 iron binding site [ion binding]; other site 311403007297 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403007298 cyclase homology domain; Region: CHD; cd07302 311403007299 nucleotidyl binding site; other site 311403007300 metal binding site [ion binding]; metal-binding site 311403007301 dimer interface [polypeptide binding]; other site 311403007302 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 311403007303 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 311403007304 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 311403007305 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403007306 cyclase homology domain; Region: CHD; cd07302 311403007307 nucleotidyl binding site; other site 311403007308 metal binding site [ion binding]; metal-binding site 311403007309 dimer interface [polypeptide binding]; other site 311403007310 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403007311 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007312 Walker A/P-loop; other site 311403007313 ATP binding site [chemical binding]; other site 311403007314 Q-loop/lid; other site 311403007315 ABC transporter signature motif; other site 311403007316 Walker B; other site 311403007317 D-loop; other site 311403007318 H-loop/switch region; other site 311403007319 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403007320 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007321 Walker A/P-loop; other site 311403007322 ATP binding site [chemical binding]; other site 311403007323 Q-loop/lid; other site 311403007324 ABC transporter signature motif; other site 311403007325 Walker B; other site 311403007326 D-loop; other site 311403007327 H-loop/switch region; other site 311403007328 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403007329 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403007330 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 311403007331 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403007332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007333 dimer interface [polypeptide binding]; other site 311403007334 conserved gate region; other site 311403007335 putative PBP binding loops; other site 311403007336 ABC-ATPase subunit interface; other site 311403007337 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403007338 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 311403007339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007340 dimer interface [polypeptide binding]; other site 311403007341 conserved gate region; other site 311403007342 putative PBP binding loops; other site 311403007343 ABC-ATPase subunit interface; other site 311403007344 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 311403007345 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 311403007346 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 311403007347 putative ADP-binding pocket [chemical binding]; other site 311403007348 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403007349 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 311403007350 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 311403007351 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403007352 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403007353 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 311403007354 Walker A/P-loop; other site 311403007355 ATP binding site [chemical binding]; other site 311403007356 Q-loop/lid; other site 311403007357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403007358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403007359 ABC transporter signature motif; other site 311403007360 Walker B; other site 311403007361 D-loop; other site 311403007362 H-loop/switch region; other site 311403007363 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403007364 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403007365 ligand binding site [chemical binding]; other site 311403007366 flexible hinge region; other site 311403007367 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403007368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403007369 S-adenosylmethionine binding site [chemical binding]; other site 311403007370 Protein of unknown function (DUF982); Region: DUF982; pfam06169 311403007371 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 311403007372 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403007373 alpha-galactosidase; Provisional; Region: PRK15076 311403007374 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 311403007375 NAD binding site [chemical binding]; other site 311403007376 sugar binding site [chemical binding]; other site 311403007377 divalent metal binding site [ion binding]; other site 311403007378 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 311403007379 dimer interface [polypeptide binding]; other site 311403007380 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 311403007381 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007382 Walker A/P-loop; other site 311403007383 ATP binding site [chemical binding]; other site 311403007384 Q-loop/lid; other site 311403007385 ABC transporter signature motif; other site 311403007386 Walker B; other site 311403007387 D-loop; other site 311403007388 H-loop/switch region; other site 311403007389 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403007390 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007391 Walker A/P-loop; other site 311403007392 ATP binding site [chemical binding]; other site 311403007393 Q-loop/lid; other site 311403007394 ABC transporter signature motif; other site 311403007395 Walker B; other site 311403007396 D-loop; other site 311403007397 H-loop/switch region; other site 311403007398 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403007399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403007400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007401 dimer interface [polypeptide binding]; other site 311403007402 conserved gate region; other site 311403007403 putative PBP binding loops; other site 311403007404 ABC-ATPase subunit interface; other site 311403007405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403007406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007407 dimer interface [polypeptide binding]; other site 311403007408 conserved gate region; other site 311403007409 putative PBP binding loops; other site 311403007410 ABC-ATPase subunit interface; other site 311403007411 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 311403007412 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403007413 alpha-galactosidase; Provisional; Region: PRK15076 311403007414 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 311403007415 NAD binding site [chemical binding]; other site 311403007416 sugar binding site [chemical binding]; other site 311403007417 divalent metal binding site [ion binding]; other site 311403007418 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 311403007419 dimer interface [polypeptide binding]; other site 311403007420 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403007421 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403007422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403007423 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 311403007424 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 311403007425 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 311403007426 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 311403007427 Hint domain; Region: Hint_2; pfam13403 311403007428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403007429 DNA-binding site [nucleotide binding]; DNA binding site 311403007430 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403007431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 311403007432 DNA-binding site [nucleotide binding]; DNA binding site 311403007433 FCD domain; Region: FCD; pfam07729 311403007434 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 311403007435 galactarate dehydratase; Region: galactar-dH20; TIGR03248 311403007436 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 311403007437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403007438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403007439 active site 311403007440 catalytic tetrad [active] 311403007441 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 311403007442 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403007443 putative ligand binding site [chemical binding]; other site 311403007444 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403007445 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403007446 Walker A/P-loop; other site 311403007447 ATP binding site [chemical binding]; other site 311403007448 Q-loop/lid; other site 311403007449 ABC transporter signature motif; other site 311403007450 Walker B; other site 311403007451 D-loop; other site 311403007452 H-loop/switch region; other site 311403007453 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403007454 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403007455 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403007456 TM-ABC transporter signature motif; other site 311403007457 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 311403007458 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 311403007459 O-Antigen ligase; Region: Wzy_C; pfam04932 311403007460 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 311403007461 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 311403007462 SLBB domain; Region: SLBB; pfam10531 311403007463 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 311403007464 Bacterial sugar transferase; Region: Bac_transf; pfam02397 311403007465 Exopolysaccharide production repressor; Region: SyrA; pfam11089 311403007466 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 311403007467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 311403007468 active site 311403007469 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 311403007470 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 311403007471 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 311403007472 active site 311403007473 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 311403007474 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 311403007475 Acyltransferase family; Region: Acyl_transf_3; pfam01757 311403007476 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 311403007477 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 311403007478 active site 311403007479 active site 311403007480 catalytic residues [active] 311403007481 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403007482 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 311403007483 Ligand binding site; other site 311403007484 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403007485 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 311403007486 active site 311403007487 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 311403007488 active site 311403007489 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 311403007490 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 311403007491 active site 311403007492 tetramer interface; other site 311403007493 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 311403007494 Chain length determinant protein; Region: Wzz; pfam02706 311403007495 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 311403007496 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 311403007497 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403007498 EamA-like transporter family; Region: EamA; pfam00892 311403007499 Predicted flavoprotein [General function prediction only]; Region: COG0431 311403007500 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403007501 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 311403007502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403007503 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 311403007504 [2Fe-2S] cluster binding site [ion binding]; other site 311403007505 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 311403007506 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 311403007507 putative di-iron ligands [ion binding]; other site 311403007508 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403007509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403007510 DNA binding site [nucleotide binding] 311403007511 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 311403007512 putative ligand binding site [chemical binding]; other site 311403007513 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 311403007514 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403007515 DNA interaction; other site 311403007516 Metal-binding active site; metal-binding site 311403007517 nickel responsive regulator; Provisional; Region: PRK02967 311403007518 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 311403007519 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 311403007520 active site 311403007521 SAM binding site [chemical binding]; other site 311403007522 homodimer interface [polypeptide binding]; other site 311403007523 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 311403007524 active site 311403007525 putative homodimer interface [polypeptide binding]; other site 311403007526 SAM binding site [chemical binding]; other site 311403007527 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 311403007528 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 311403007529 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 311403007530 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 311403007531 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 311403007532 active site 311403007533 SAM binding site [chemical binding]; other site 311403007534 homodimer interface [polypeptide binding]; other site 311403007535 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 311403007536 active site 311403007537 SAM binding site [chemical binding]; other site 311403007538 homodimer interface [polypeptide binding]; other site 311403007539 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 311403007540 precorrin-8X methylmutase; Validated; Region: cbiC; PRK05575 311403007541 precorrin-3B synthase; Region: CobG; TIGR02435 311403007542 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 311403007543 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 311403007544 active site 311403007545 SAM binding site [chemical binding]; other site 311403007546 homodimer interface [polypeptide binding]; other site 311403007547 Methyltransferase domain; Region: Methyltransf_24; pfam13578 311403007548 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 311403007549 FAD binding domain; Region: FAD_binding_2; pfam00890 311403007550 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403007551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403007552 dimerization interface [polypeptide binding]; other site 311403007553 putative Zn2+ binding site [ion binding]; other site 311403007554 putative DNA binding site [nucleotide binding]; other site 311403007555 AsnC family; Region: AsnC_trans_reg; pfam01037 311403007556 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 311403007557 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 311403007558 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 311403007559 Glutamate binding site [chemical binding]; other site 311403007560 NAD binding site [chemical binding]; other site 311403007561 catalytic residues [active] 311403007562 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 311403007563 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 311403007564 phenylhydantoinase; Validated; Region: PRK08323 311403007565 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 311403007566 tetramer interface [polypeptide binding]; other site 311403007567 active site 311403007568 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403007569 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403007570 Walker A/P-loop; other site 311403007571 ATP binding site [chemical binding]; other site 311403007572 Q-loop/lid; other site 311403007573 ABC transporter signature motif; other site 311403007574 Walker B; other site 311403007575 D-loop; other site 311403007576 H-loop/switch region; other site 311403007577 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403007578 catalytic loop [active] 311403007579 iron binding site [ion binding]; other site 311403007580 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 311403007581 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403007582 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403007583 dihydrodipicolinate synthase; Region: dapA; TIGR00674 311403007584 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403007585 inhibitor site; inhibition site 311403007586 active site 311403007587 dimer interface [polypeptide binding]; other site 311403007588 catalytic residue [active] 311403007589 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403007590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007591 dimer interface [polypeptide binding]; other site 311403007592 conserved gate region; other site 311403007593 putative PBP binding loops; other site 311403007594 ABC-ATPase subunit interface; other site 311403007595 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403007596 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403007597 substrate binding pocket [chemical binding]; other site 311403007598 membrane-bound complex binding site; other site 311403007599 hinge residues; other site 311403007600 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403007601 FCD domain; Region: FCD; pfam07729 311403007602 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403007603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403007604 DNA-binding site [nucleotide binding]; DNA binding site 311403007605 FCD domain; Region: FCD; pfam07729 311403007606 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403007607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403007608 Walker A/P-loop; other site 311403007609 ATP binding site [chemical binding]; other site 311403007610 Q-loop/lid; other site 311403007611 ABC transporter signature motif; other site 311403007612 Walker B; other site 311403007613 D-loop; other site 311403007614 H-loop/switch region; other site 311403007615 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403007616 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403007617 TM-ABC transporter signature motif; other site 311403007618 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 311403007619 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403007620 putative ligand binding site [chemical binding]; other site 311403007621 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403007622 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403007623 nucleotide binding site [chemical binding]; other site 311403007624 AAA domain; Region: AAA_33; pfam13671 311403007625 AAA domain; Region: AAA_17; pfam13207 311403007626 Class I aldolases; Region: Aldolase_Class_I; cl17187 311403007627 catalytic residue [active] 311403007628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403007629 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403007630 DNA binding residues [nucleotide binding] 311403007631 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403007632 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 311403007633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 311403007634 motif II; other site 311403007635 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 311403007636 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403007637 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 311403007638 substrate binding site [chemical binding]; other site 311403007639 ATP binding site [chemical binding]; other site 311403007640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403007641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403007642 DNA binding site [nucleotide binding] 311403007643 domain linker motif; other site 311403007644 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403007645 dimerization interface [polypeptide binding]; other site 311403007646 ligand binding site [chemical binding]; other site 311403007647 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 311403007648 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403007649 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403007650 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403007651 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403007652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403007653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007654 dimer interface [polypeptide binding]; other site 311403007655 conserved gate region; other site 311403007656 putative PBP binding loops; other site 311403007657 ABC-ATPase subunit interface; other site 311403007658 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403007659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007660 dimer interface [polypeptide binding]; other site 311403007661 conserved gate region; other site 311403007662 putative PBP binding loops; other site 311403007663 ABC-ATPase subunit interface; other site 311403007664 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403007665 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403007666 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403007667 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403007668 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403007669 Metal-binding active site; metal-binding site 311403007670 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403007671 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 311403007672 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 311403007673 substrate binding site [chemical binding]; other site 311403007674 hexamer interface [polypeptide binding]; other site 311403007675 metal binding site [ion binding]; metal-binding site 311403007676 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403007677 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403007678 nucleotide binding site [chemical binding]; other site 311403007679 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 311403007680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403007681 Walker A/P-loop; other site 311403007682 ATP binding site [chemical binding]; other site 311403007683 Q-loop/lid; other site 311403007684 ABC transporter signature motif; other site 311403007685 Walker B; other site 311403007686 D-loop; other site 311403007687 H-loop/switch region; other site 311403007688 TOBE domain; Region: TOBE_2; pfam08402 311403007689 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403007690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007691 Walker A/P-loop; other site 311403007692 ATP binding site [chemical binding]; other site 311403007693 Q-loop/lid; other site 311403007694 ABC transporter signature motif; other site 311403007695 Walker B; other site 311403007696 D-loop; other site 311403007697 H-loop/switch region; other site 311403007698 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403007699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007700 Walker A/P-loop; other site 311403007701 ATP binding site [chemical binding]; other site 311403007702 Q-loop/lid; other site 311403007703 ABC transporter signature motif; other site 311403007704 Walker B; other site 311403007705 D-loop; other site 311403007706 H-loop/switch region; other site 311403007707 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403007708 MarR family; Region: MarR_2; pfam12802 311403007709 short chain dehydrogenase; Provisional; Region: PRK08219 311403007710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403007711 NAD(P) binding site [chemical binding]; other site 311403007712 active site 311403007713 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403007714 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403007715 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 311403007716 peptide binding site [polypeptide binding]; other site 311403007717 dimer interface [polypeptide binding]; other site 311403007718 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403007719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007720 dimer interface [polypeptide binding]; other site 311403007721 conserved gate region; other site 311403007722 putative PBP binding loops; other site 311403007723 ABC-ATPase subunit interface; other site 311403007724 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403007725 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403007726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007727 dimer interface [polypeptide binding]; other site 311403007728 conserved gate region; other site 311403007729 putative PBP binding loops; other site 311403007730 ABC-ATPase subunit interface; other site 311403007731 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403007732 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403007733 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 311403007734 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 311403007735 N- and C-terminal domain interface [polypeptide binding]; other site 311403007736 active site 311403007737 MgATP binding site [chemical binding]; other site 311403007738 catalytic site [active] 311403007739 metal binding site [ion binding]; metal-binding site 311403007740 carbohydrate binding site [chemical binding]; other site 311403007741 putative homodimer interface [polypeptide binding]; other site 311403007742 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 311403007743 classical (c) SDRs; Region: SDR_c; cd05233 311403007744 NAD(P) binding site [chemical binding]; other site 311403007745 active site 311403007746 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403007747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403007748 TM-ABC transporter signature motif; other site 311403007749 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 311403007750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403007751 Walker A/P-loop; other site 311403007752 ATP binding site [chemical binding]; other site 311403007753 Q-loop/lid; other site 311403007754 ABC transporter signature motif; other site 311403007755 Walker B; other site 311403007756 D-loop; other site 311403007757 H-loop/switch region; other site 311403007758 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 311403007759 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 311403007760 putative ligand binding site [chemical binding]; other site 311403007761 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403007762 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403007763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403007764 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 311403007765 HAMP domain; Region: HAMP; pfam00672 311403007766 dimerization interface [polypeptide binding]; other site 311403007767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403007768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403007769 dimer interface [polypeptide binding]; other site 311403007770 putative CheW interface [polypeptide binding]; other site 311403007771 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403007772 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403007773 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403007774 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403007775 Walker A/P-loop; other site 311403007776 ATP binding site [chemical binding]; other site 311403007777 Q-loop/lid; other site 311403007778 ABC transporter signature motif; other site 311403007779 Walker B; other site 311403007780 D-loop; other site 311403007781 H-loop/switch region; other site 311403007782 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403007783 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403007784 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403007785 TM-ABC transporter signature motif; other site 311403007786 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403007787 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403007788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403007789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403007790 DNA binding site [nucleotide binding] 311403007791 domain linker motif; other site 311403007792 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 311403007793 putative dimerization interface [polypeptide binding]; other site 311403007794 putative ligand binding site [chemical binding]; other site 311403007795 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 311403007796 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 311403007797 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 311403007798 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 311403007799 NADP binding site [chemical binding]; other site 311403007800 homodimer interface [polypeptide binding]; other site 311403007801 active site 311403007802 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 311403007803 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 311403007804 putative ligand binding site [chemical binding]; other site 311403007805 NAD binding site [chemical binding]; other site 311403007806 catalytic site [active] 311403007807 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 311403007808 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 311403007809 putative NAD(P) binding site [chemical binding]; other site 311403007810 catalytic Zn binding site [ion binding]; other site 311403007811 Domain of unknown function (DUF336); Region: DUF336; cl01249 311403007812 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 311403007813 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 311403007814 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403007815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007816 Walker A/P-loop; other site 311403007817 ATP binding site [chemical binding]; other site 311403007818 Q-loop/lid; other site 311403007819 ABC transporter signature motif; other site 311403007820 Walker B; other site 311403007821 D-loop; other site 311403007822 H-loop/switch region; other site 311403007823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007824 Walker A/P-loop; other site 311403007825 ATP binding site [chemical binding]; other site 311403007826 Q-loop/lid; other site 311403007827 ABC transporter signature motif; other site 311403007828 Walker B; other site 311403007829 D-loop; other site 311403007830 H-loop/switch region; other site 311403007831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403007832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403007833 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403007834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007835 dimer interface [polypeptide binding]; other site 311403007836 conserved gate region; other site 311403007837 ABC-ATPase subunit interface; other site 311403007838 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403007839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007840 dimer interface [polypeptide binding]; other site 311403007841 conserved gate region; other site 311403007842 ABC-ATPase subunit interface; other site 311403007843 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 311403007844 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 311403007845 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403007846 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 311403007847 metal binding site [ion binding]; metal-binding site 311403007848 dimer interface [polypeptide binding]; other site 311403007849 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 311403007850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403007851 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 311403007852 DNA binding residues [nucleotide binding] 311403007853 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 311403007854 FecR protein; Region: FecR; pfam04773 311403007855 Secretin and TonB N terminus short domain; Region: STN; smart00965 311403007856 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 311403007857 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 311403007858 N-terminal plug; other site 311403007859 ligand-binding site [chemical binding]; other site 311403007860 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 311403007861 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 311403007862 intersubunit interface [polypeptide binding]; other site 311403007863 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; cl01424 311403007864 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 311403007865 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 311403007866 FAD binding pocket [chemical binding]; other site 311403007867 FAD binding motif [chemical binding]; other site 311403007868 phosphate binding motif [ion binding]; other site 311403007869 NAD binding pocket [chemical binding]; other site 311403007870 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 311403007871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403007872 HAMP domain; Region: HAMP; pfam00672 311403007873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403007874 dimer interface [polypeptide binding]; other site 311403007875 phosphorylation site [posttranslational modification] 311403007876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403007877 ATP binding site [chemical binding]; other site 311403007878 Mg2+ binding site [ion binding]; other site 311403007879 G-X-G motif; other site 311403007880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403007881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403007882 active site 311403007883 phosphorylation site [posttranslational modification] 311403007884 intermolecular recognition site; other site 311403007885 dimerization interface [polypeptide binding]; other site 311403007886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403007887 DNA binding site [nucleotide binding] 311403007888 Uncharacterized conserved protein [Function unknown]; Region: COG3791 311403007889 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403007890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007891 Walker A/P-loop; other site 311403007892 ATP binding site [chemical binding]; other site 311403007893 Q-loop/lid; other site 311403007894 ABC transporter signature motif; other site 311403007895 Walker B; other site 311403007896 D-loop; other site 311403007897 H-loop/switch region; other site 311403007898 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403007899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403007900 Walker A/P-loop; other site 311403007901 ATP binding site [chemical binding]; other site 311403007902 Q-loop/lid; other site 311403007903 ABC transporter signature motif; other site 311403007904 Walker B; other site 311403007905 D-loop; other site 311403007906 H-loop/switch region; other site 311403007907 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403007908 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403007909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007910 ABC-ATPase subunit interface; other site 311403007911 putative PBP binding loops; other site 311403007912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403007913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007914 dimer interface [polypeptide binding]; other site 311403007915 conserved gate region; other site 311403007916 putative PBP binding loops; other site 311403007917 ABC-ATPase subunit interface; other site 311403007918 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403007919 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 311403007920 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403007921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403007922 DNA-binding site [nucleotide binding]; DNA binding site 311403007923 FCD domain; Region: FCD; pfam07729 311403007924 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 311403007925 mannonate dehydratase; Region: uxuA; TIGR00695 311403007926 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 311403007927 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403007928 putative active site [active] 311403007929 catalytic residue [active] 311403007930 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 311403007931 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403007932 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403007933 Flavin binding site [chemical binding]; other site 311403007934 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403007935 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403007936 Walker A/P-loop; other site 311403007937 ATP binding site [chemical binding]; other site 311403007938 Q-loop/lid; other site 311403007939 ABC transporter signature motif; other site 311403007940 Walker B; other site 311403007941 D-loop; other site 311403007942 H-loop/switch region; other site 311403007943 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 311403007944 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403007945 putative ligand binding site [chemical binding]; other site 311403007946 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403007947 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403007948 TM-ABC transporter signature motif; other site 311403007949 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403007950 TM-ABC transporter signature motif; other site 311403007951 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 311403007952 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403007953 active site 311403007954 dimer interface [polypeptide binding]; other site 311403007955 non-prolyl cis peptide bond; other site 311403007956 insertion regions; other site 311403007957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403007958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403007959 active site 311403007960 catalytic tetrad [active] 311403007961 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403007962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403007963 Walker A/P-loop; other site 311403007964 ATP binding site [chemical binding]; other site 311403007965 Q-loop/lid; other site 311403007966 ABC transporter signature motif; other site 311403007967 Walker B; other site 311403007968 D-loop; other site 311403007969 H-loop/switch region; other site 311403007970 TOBE domain; Region: TOBE_2; pfam08402 311403007971 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403007972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007973 putative PBP binding loops; other site 311403007974 ABC-ATPase subunit interface; other site 311403007975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403007976 dimer interface [polypeptide binding]; other site 311403007977 conserved gate region; other site 311403007978 putative PBP binding loops; other site 311403007979 ABC-ATPase subunit interface; other site 311403007980 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403007981 NIPSNAP; Region: NIPSNAP; pfam07978 311403007982 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403007983 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 311403007984 NAD(P) binding site [chemical binding]; other site 311403007985 catalytic residues [active] 311403007986 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403007987 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403007988 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 311403007989 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403007990 Amino acid synthesis; Region: AA_synth; pfam06684 311403007991 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403007992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403007993 DNA-binding site [nucleotide binding]; DNA binding site 311403007994 FCD domain; Region: FCD; pfam07729 311403007995 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 311403007996 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 311403007997 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 311403007998 Ligand Binding Site [chemical binding]; other site 311403007999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 311403008000 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403008001 dimer interface [polypeptide binding]; other site 311403008002 phosphorylation site [posttranslational modification] 311403008003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403008004 ATP binding site [chemical binding]; other site 311403008005 Mg2+ binding site [ion binding]; other site 311403008006 G-X-G motif; other site 311403008007 Response regulator receiver domain; Region: Response_reg; pfam00072 311403008008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403008009 active site 311403008010 phosphorylation site [posttranslational modification] 311403008011 intermolecular recognition site; other site 311403008012 dimerization interface [polypeptide binding]; other site 311403008013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403008014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403008015 active site 311403008016 phosphorylation site [posttranslational modification] 311403008017 intermolecular recognition site; other site 311403008018 dimerization interface [polypeptide binding]; other site 311403008019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403008020 DNA binding residues [nucleotide binding] 311403008021 dimerization interface [polypeptide binding]; other site 311403008022 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403008023 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 311403008024 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 311403008025 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 311403008026 homodimer interface [polypeptide binding]; other site 311403008027 substrate-cofactor binding pocket; other site 311403008028 catalytic residue [active] 311403008029 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 311403008030 oligomeric interface; other site 311403008031 putative active site [active] 311403008032 homodimer interface [polypeptide binding]; other site 311403008033 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 311403008034 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 311403008035 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 311403008036 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 311403008037 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 311403008038 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 311403008039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403008040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403008041 putative substrate translocation pore; other site 311403008042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403008043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403008044 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 311403008045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403008046 DNA-binding site [nucleotide binding]; DNA binding site 311403008047 FCD domain; Region: FCD; pfam07729 311403008048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 311403008049 Carboxylesterase family; Region: COesterase; pfam00135 311403008050 substrate binding pocket [chemical binding]; other site 311403008051 catalytic triad [active] 311403008052 Carboxylesterase family; Region: COesterase; pfam00135 311403008053 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 311403008054 substrate binding pocket [chemical binding]; other site 311403008055 catalytic triad [active] 311403008056 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 311403008057 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403008058 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 311403008059 tyramine oxidase; Provisional; Region: tynA; PRK11504 311403008060 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 311403008061 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 311403008062 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 311403008063 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 311403008064 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403008065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403008066 Walker A/P-loop; other site 311403008067 ATP binding site [chemical binding]; other site 311403008068 Q-loop/lid; other site 311403008069 ABC transporter signature motif; other site 311403008070 Walker B; other site 311403008071 D-loop; other site 311403008072 H-loop/switch region; other site 311403008073 TOBE domain; Region: TOBE_2; pfam08402 311403008074 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403008075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008076 dimer interface [polypeptide binding]; other site 311403008077 conserved gate region; other site 311403008078 putative PBP binding loops; other site 311403008079 ABC-ATPase subunit interface; other site 311403008080 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 311403008081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008082 dimer interface [polypeptide binding]; other site 311403008083 conserved gate region; other site 311403008084 putative PBP binding loops; other site 311403008085 ABC-ATPase subunit interface; other site 311403008086 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403008087 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403008088 hypothetical protein; Provisional; Region: PRK11622 311403008089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403008090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403008091 DNA binding site [nucleotide binding] 311403008092 domain linker motif; other site 311403008093 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 311403008094 ligand binding site [chemical binding]; other site 311403008095 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403008096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403008097 DNA-binding site [nucleotide binding]; DNA binding site 311403008098 FCD domain; Region: FCD; pfam07729 311403008099 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403008100 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 311403008101 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403008102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008103 dimer interface [polypeptide binding]; other site 311403008104 conserved gate region; other site 311403008105 putative PBP binding loops; other site 311403008106 ABC-ATPase subunit interface; other site 311403008107 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403008108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008109 dimer interface [polypeptide binding]; other site 311403008110 conserved gate region; other site 311403008111 putative PBP binding loops; other site 311403008112 ABC-ATPase subunit interface; other site 311403008113 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403008114 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403008115 inhibitor site; inhibition site 311403008116 active site 311403008117 dimer interface [polypeptide binding]; other site 311403008118 catalytic residue [active] 311403008119 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403008120 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403008121 Walker A/P-loop; other site 311403008122 ATP binding site [chemical binding]; other site 311403008123 Q-loop/lid; other site 311403008124 ABC transporter signature motif; other site 311403008125 Walker B; other site 311403008126 D-loop; other site 311403008127 H-loop/switch region; other site 311403008128 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403008129 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 311403008130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403008131 Walker A/P-loop; other site 311403008132 ATP binding site [chemical binding]; other site 311403008133 Q-loop/lid; other site 311403008134 ABC transporter signature motif; other site 311403008135 Walker B; other site 311403008136 D-loop; other site 311403008137 H-loop/switch region; other site 311403008138 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403008139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403008140 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403008141 Coenzyme A binding pocket [chemical binding]; other site 311403008142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 311403008143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 311403008144 Predicted integral membrane protein [Function unknown]; Region: COG5612 311403008145 RNA polymerase sigma factor; Reviewed; Region: PRK05602 311403008146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403008147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403008148 DNA binding residues [nucleotide binding] 311403008149 hypothetical protein; Validated; Region: PRK09104 311403008150 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 311403008151 metal binding site [ion binding]; metal-binding site 311403008152 putative dimer interface [polypeptide binding]; other site 311403008153 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403008154 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 311403008155 inhibitor site; inhibition site 311403008156 active site 311403008157 dimer interface [polypeptide binding]; other site 311403008158 catalytic residue [active] 311403008159 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403008160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 311403008161 DNA-binding site [nucleotide binding]; DNA binding site 311403008162 FCD domain; Region: FCD; pfam07729 311403008163 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403008164 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403008165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008166 dimer interface [polypeptide binding]; other site 311403008167 conserved gate region; other site 311403008168 putative PBP binding loops; other site 311403008169 ABC-ATPase subunit interface; other site 311403008170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008172 putative PBP binding loops; other site 311403008173 ABC-ATPase subunit interface; other site 311403008174 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403008175 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403008176 Walker A/P-loop; other site 311403008177 ATP binding site [chemical binding]; other site 311403008178 Q-loop/lid; other site 311403008179 ABC transporter signature motif; other site 311403008180 Walker B; other site 311403008181 D-loop; other site 311403008182 H-loop/switch region; other site 311403008183 TOBE domain; Region: TOBE_2; pfam08402 311403008184 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 311403008185 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403008186 substrate binding site [chemical binding]; other site 311403008187 ATP binding site [chemical binding]; other site 311403008188 allantoate amidohydrolase; Reviewed; Region: PRK12893 311403008189 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 311403008190 active site 311403008191 metal binding site [ion binding]; metal-binding site 311403008192 dimer interface [polypeptide binding]; other site 311403008193 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 311403008194 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403008195 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 311403008196 substrate binding site [chemical binding]; other site 311403008197 dimer interface [polypeptide binding]; other site 311403008198 ATP binding site [chemical binding]; other site 311403008199 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 311403008200 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 311403008201 active site 311403008202 substrate binding pocket [chemical binding]; other site 311403008203 homodimer interaction site [polypeptide binding]; other site 311403008204 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403008205 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403008206 TM-ABC transporter signature motif; other site 311403008207 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 311403008208 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403008209 Walker A/P-loop; other site 311403008210 ATP binding site [chemical binding]; other site 311403008211 Q-loop/lid; other site 311403008212 ABC transporter signature motif; other site 311403008213 Walker B; other site 311403008214 D-loop; other site 311403008215 H-loop/switch region; other site 311403008216 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403008217 ligand binding site [chemical binding]; other site 311403008218 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403008219 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 311403008220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403008221 non-specific DNA binding site [nucleotide binding]; other site 311403008222 salt bridge; other site 311403008223 sequence-specific DNA binding site [nucleotide binding]; other site 311403008224 Cupin domain; Region: Cupin_2; pfam07883 311403008225 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 311403008226 HipA N-terminal domain; Region: Couple_hipA; cl11853 311403008227 HipA-like N-terminal domain; Region: HipA_N; pfam07805 311403008228 HipA-like C-terminal domain; Region: HipA_C; pfam07804 311403008229 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403008230 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 311403008231 active site 311403008232 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 311403008233 Phosphotransferase enzyme family; Region: APH; pfam01636 311403008234 active site 311403008235 ATP binding site [chemical binding]; other site 311403008236 substrate binding site [chemical binding]; other site 311403008237 dimer interface [polypeptide binding]; other site 311403008238 Phosphotransferase enzyme family; Region: APH; pfam01636 311403008239 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 311403008240 active site 311403008241 ATP binding site [chemical binding]; other site 311403008242 substrate binding site [chemical binding]; other site 311403008243 allantoate amidohydrolase; Reviewed; Region: PRK09290 311403008244 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 311403008245 active site 311403008246 metal binding site [ion binding]; metal-binding site 311403008247 dimer interface [polypeptide binding]; other site 311403008248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403008249 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403008250 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403008251 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403008252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403008253 Walker A/P-loop; other site 311403008254 ATP binding site [chemical binding]; other site 311403008255 Q-loop/lid; other site 311403008256 ABC transporter signature motif; other site 311403008257 Walker B; other site 311403008258 D-loop; other site 311403008259 H-loop/switch region; other site 311403008260 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403008261 Walker A/P-loop; other site 311403008262 ATP binding site [chemical binding]; other site 311403008263 Q-loop/lid; other site 311403008264 ABC transporter signature motif; other site 311403008265 Walker B; other site 311403008266 D-loop; other site 311403008267 H-loop/switch region; other site 311403008268 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403008269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403008270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008271 dimer interface [polypeptide binding]; other site 311403008272 conserved gate region; other site 311403008273 putative PBP binding loops; other site 311403008274 ABC-ATPase subunit interface; other site 311403008275 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403008276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008277 dimer interface [polypeptide binding]; other site 311403008278 conserved gate region; other site 311403008279 putative PBP binding loops; other site 311403008280 ABC-ATPase subunit interface; other site 311403008281 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 311403008282 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 311403008283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 311403008284 Integrase core domain; Region: rve; pfam00665 311403008285 Integrase core domain; Region: rve_3; pfam13683 311403008286 Transposase; Region: HTH_Tnp_1; pfam01527 311403008287 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403008288 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403008289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008290 dimer interface [polypeptide binding]; other site 311403008291 conserved gate region; other site 311403008292 putative PBP binding loops; other site 311403008293 ABC-ATPase subunit interface; other site 311403008294 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403008295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008296 dimer interface [polypeptide binding]; other site 311403008297 conserved gate region; other site 311403008298 putative PBP binding loops; other site 311403008299 ABC-ATPase subunit interface; other site 311403008300 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403008301 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403008302 Walker A/P-loop; other site 311403008303 ATP binding site [chemical binding]; other site 311403008304 Q-loop/lid; other site 311403008305 ABC transporter signature motif; other site 311403008306 Walker B; other site 311403008307 D-loop; other site 311403008308 H-loop/switch region; other site 311403008309 TOBE domain; Region: TOBE_2; pfam08402 311403008310 acetylornithine deacetylase; Provisional; Region: PRK07522 311403008311 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 311403008312 metal binding site [ion binding]; metal-binding site 311403008313 putative dimer interface [polypeptide binding]; other site 311403008314 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 311403008315 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 311403008316 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 311403008317 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 311403008318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403008319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403008320 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 311403008321 putative substrate binding pocket [chemical binding]; other site 311403008322 dimerization interface [polypeptide binding]; other site 311403008323 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 311403008324 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 311403008325 homotrimer interaction site [polypeptide binding]; other site 311403008326 putative active site [active] 311403008327 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 311403008328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403008329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403008330 Walker B; other site 311403008331 D-loop; other site 311403008332 H-loop/switch region; other site 311403008333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 311403008334 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403008335 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 311403008336 Uncharacterized conserved protein [Function unknown]; Region: COG5397 311403008337 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 311403008338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403008339 putative substrate translocation pore; other site 311403008340 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403008341 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403008342 active site 311403008343 catalytic tetrad [active] 311403008344 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403008345 Cupin; Region: Cupin_6; pfam12852 311403008346 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403008347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403008348 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 311403008349 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403008350 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403008351 active site 311403008352 metal binding site [ion binding]; metal-binding site 311403008353 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 311403008354 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 311403008355 active site 311403008356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403008357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403008358 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403008359 putative effector binding pocket; other site 311403008360 dimerization interface [polypeptide binding]; other site 311403008361 Predicted acetyltransferase [General function prediction only]; Region: COG2388 311403008362 Pirin-related protein [General function prediction only]; Region: COG1741 311403008363 Pirin; Region: Pirin; pfam02678 311403008364 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 311403008365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403008366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403008367 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403008368 putative effector binding pocket; other site 311403008369 dimerization interface [polypeptide binding]; other site 311403008370 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 311403008371 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403008372 Isochorismatase family; Region: Isochorismatase; pfam00857 311403008373 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 311403008374 catalytic triad [active] 311403008375 dimer interface [polypeptide binding]; other site 311403008376 conserved cis-peptide bond; other site 311403008377 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403008378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403008379 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403008380 putative effector binding pocket; other site 311403008381 dimerization interface [polypeptide binding]; other site 311403008382 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403008383 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 311403008384 NAD(P) binding site [chemical binding]; other site 311403008385 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403008386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403008387 NAD(P) binding site [chemical binding]; other site 311403008388 active site 311403008389 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 311403008390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403008391 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403008392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403008393 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 311403008394 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 311403008395 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403008396 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 311403008397 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 311403008398 active site 311403008399 HIGH motif; other site 311403008400 KMSKS motif; other site 311403008401 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 311403008402 anticodon binding site; other site 311403008403 tRNA binding surface [nucleotide binding]; other site 311403008404 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 311403008405 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403008406 substrate binding site [chemical binding]; other site 311403008407 oxyanion hole (OAH) forming residues; other site 311403008408 trimer interface [polypeptide binding]; other site 311403008409 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403008410 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403008411 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403008412 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403008413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403008414 dimerization interface [polypeptide binding]; other site 311403008415 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403008416 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403008417 Walker A/P-loop; other site 311403008418 ATP binding site [chemical binding]; other site 311403008419 Q-loop/lid; other site 311403008420 ABC transporter signature motif; other site 311403008421 Walker B; other site 311403008422 D-loop; other site 311403008423 H-loop/switch region; other site 311403008424 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403008425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403008426 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 311403008427 NMT1/THI5 like; Region: NMT1; pfam09084 311403008428 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 311403008429 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 311403008430 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 311403008431 active site 311403008432 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 311403008433 nucleoside/Zn binding site; other site 311403008434 dimer interface [polypeptide binding]; other site 311403008435 catalytic motif [active] 311403008436 aldehyde oxidase; Region: mam_aldehyde_ox; TIGR02969 311403008437 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 311403008438 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 311403008439 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403008440 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 311403008441 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 311403008442 N- and C-terminal domain interface [polypeptide binding]; other site 311403008443 putative active site [active] 311403008444 MgATP binding site [chemical binding]; other site 311403008445 catalytic site [active] 311403008446 metal binding site [ion binding]; metal-binding site 311403008447 putative xylulose binding site [chemical binding]; other site 311403008448 putative homodimer interface [polypeptide binding]; other site 311403008449 BtpA family; Region: BtpA; cl00440 311403008450 allophanate hydrolase; Provisional; Region: PRK08186 311403008451 Amidase; Region: Amidase; cl11426 311403008452 Isochorismatase family; Region: Isochorismatase; pfam00857 311403008453 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 311403008454 catalytic triad [active] 311403008455 conserved cis-peptide bond; other site 311403008456 Isochorismatase family; Region: Isochorismatase; pfam00857 311403008457 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 311403008458 catalytic triad [active] 311403008459 conserved cis-peptide bond; other site 311403008460 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403008461 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403008462 Walker A/P-loop; other site 311403008463 ATP binding site [chemical binding]; other site 311403008464 Q-loop/lid; other site 311403008465 ABC transporter signature motif; other site 311403008466 Walker B; other site 311403008467 D-loop; other site 311403008468 H-loop/switch region; other site 311403008469 TOBE domain; Region: TOBE_2; pfam08402 311403008470 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403008471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008472 dimer interface [polypeptide binding]; other site 311403008473 conserved gate region; other site 311403008474 putative PBP binding loops; other site 311403008475 ABC-ATPase subunit interface; other site 311403008476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008477 dimer interface [polypeptide binding]; other site 311403008478 conserved gate region; other site 311403008479 putative PBP binding loops; other site 311403008480 ABC-ATPase subunit interface; other site 311403008481 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403008482 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403008483 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 311403008484 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 311403008485 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 311403008486 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403008487 classical (c) SDRs; Region: SDR_c; cd05233 311403008488 NAD(P) binding site [chemical binding]; other site 311403008489 active site 311403008490 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403008491 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403008492 cytosine deaminase; Provisional; Region: PRK05985 311403008493 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 311403008494 active site 311403008495 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 311403008496 active site 311403008497 catalytic site [active] 311403008498 substrate binding site [chemical binding]; other site 311403008499 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 311403008500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403008501 S-adenosylmethionine binding site [chemical binding]; other site 311403008502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403008503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403008504 RibD C-terminal domain; Region: RibD_C; cl17279 311403008505 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 311403008506 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 311403008507 generic binding surface I; other site 311403008508 generic binding surface II; other site 311403008509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403008510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403008511 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 311403008512 classical (c) SDRs; Region: SDR_c; cd05233 311403008513 NAD(P) binding site [chemical binding]; other site 311403008514 active site 311403008515 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403008516 dimerization interface [polypeptide binding]; other site 311403008517 putative DNA binding site [nucleotide binding]; other site 311403008518 putative Zn2+ binding site [ion binding]; other site 311403008519 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403008520 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403008521 Predicted integral membrane protein [Function unknown]; Region: COG5473 311403008522 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 311403008523 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 311403008524 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 311403008525 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 311403008526 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 311403008527 Subunit I/III interface [polypeptide binding]; other site 311403008528 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 311403008529 Subunit I/III interface [polypeptide binding]; other site 311403008530 Predicted small integral membrane protein [Function unknown]; Region: COG5605 311403008531 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 311403008532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 311403008533 Acylphosphatase; Region: Acylphosphatase; cl00551 311403008534 rod shape-determining protein MreC; Provisional; Region: PRK13922 311403008535 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403008536 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403008537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403008538 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403008539 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403008540 DNA binding residues [nucleotide binding] 311403008541 dimerization interface [polypeptide binding]; other site 311403008542 Alcaligenes xylosoxidans NreA and related domains; this domain family was previously known as part of DUF156; Region: NreA-like_DUF156; cd10154 311403008543 putative homodimer interface [polypeptide binding]; other site 311403008544 putative homotetramer interface [polypeptide binding]; other site 311403008545 putative metal binding site [ion binding]; other site 311403008546 putative homodimer-homodimer interface [polypeptide binding]; other site 311403008547 putative allosteric switch controlling residues; other site 311403008548 High-affinity nickel-transport protein; Region: NicO; cl00964 311403008549 High-affinity nickel-transport protein; Region: NicO; cl00964 311403008550 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403008551 Coenzyme A binding pocket [chemical binding]; other site 311403008552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403008553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008554 putative PBP binding loops; other site 311403008555 ABC-ATPase subunit interface; other site 311403008556 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403008557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008558 dimer interface [polypeptide binding]; other site 311403008559 conserved gate region; other site 311403008560 putative PBP binding loops; other site 311403008561 ABC-ATPase subunit interface; other site 311403008562 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403008563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403008564 DNA-binding site [nucleotide binding]; DNA binding site 311403008565 FCD domain; Region: FCD; pfam07729 311403008566 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403008567 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403008568 Walker A/P-loop; other site 311403008569 ATP binding site [chemical binding]; other site 311403008570 Q-loop/lid; other site 311403008571 ABC transporter signature motif; other site 311403008572 Walker B; other site 311403008573 D-loop; other site 311403008574 H-loop/switch region; other site 311403008575 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403008576 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403008577 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403008578 Walker A/P-loop; other site 311403008579 ATP binding site [chemical binding]; other site 311403008580 Q-loop/lid; other site 311403008581 ABC transporter signature motif; other site 311403008582 Walker B; other site 311403008583 D-loop; other site 311403008584 H-loop/switch region; other site 311403008585 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403008586 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 311403008587 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 311403008588 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403008589 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403008590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 311403008591 Transposase; Region: HTH_Tnp_1; pfam01527 311403008592 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403008593 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 311403008594 HTH-like domain; Region: HTH_21; pfam13276 311403008595 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 311403008596 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 311403008597 putative active site [active] 311403008598 putative NTP binding site [chemical binding]; other site 311403008599 putative nucleic acid binding site [nucleotide binding]; other site 311403008600 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 311403008601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403008602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403008603 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403008604 putative effector binding pocket; other site 311403008605 putative dimerization interface [polypeptide binding]; other site 311403008606 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 311403008607 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 311403008608 putative active site [active] 311403008609 putative FMN binding site [chemical binding]; other site 311403008610 putative substrate binding site [chemical binding]; other site 311403008611 putative catalytic residue [active] 311403008612 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 311403008613 nudix motif; other site 311403008614 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403008615 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403008616 DNA binding site [nucleotide binding] 311403008617 domain linker motif; other site 311403008618 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 311403008619 putative dimerization interface [polypeptide binding]; other site 311403008620 putative ligand binding site [chemical binding]; other site 311403008621 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403008622 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403008623 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 311403008624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008625 dimer interface [polypeptide binding]; other site 311403008626 conserved gate region; other site 311403008627 putative PBP binding loops; other site 311403008628 ABC-ATPase subunit interface; other site 311403008629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008630 dimer interface [polypeptide binding]; other site 311403008631 conserved gate region; other site 311403008632 putative PBP binding loops; other site 311403008633 ABC-ATPase subunit interface; other site 311403008634 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403008635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403008636 Walker A/P-loop; other site 311403008637 ATP binding site [chemical binding]; other site 311403008638 Q-loop/lid; other site 311403008639 ABC transporter signature motif; other site 311403008640 Walker B; other site 311403008641 D-loop; other site 311403008642 H-loop/switch region; other site 311403008643 TOBE domain; Region: TOBE_2; pfam08402 311403008644 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403008645 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 311403008646 active site 311403008647 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 311403008648 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 311403008649 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 311403008650 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 311403008651 DXD motif; other site 311403008652 PilZ domain; Region: PilZ; pfam07238 311403008653 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 311403008654 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 311403008655 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 311403008656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403008657 PAS domain; Region: PAS_9; pfam13426 311403008658 putative active site [active] 311403008659 heme pocket [chemical binding]; other site 311403008660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403008661 PAS domain; Region: PAS_9; pfam13426 311403008662 putative active site [active] 311403008663 heme pocket [chemical binding]; other site 311403008664 PAS domain S-box; Region: sensory_box; TIGR00229 311403008665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403008666 putative active site [active] 311403008667 heme pocket [chemical binding]; other site 311403008668 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403008669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403008670 metal binding site [ion binding]; metal-binding site 311403008671 active site 311403008672 I-site; other site 311403008673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403008674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403008675 DNA binding site [nucleotide binding] 311403008676 domain linker motif; other site 311403008677 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403008678 dimerization interface [polypeptide binding]; other site 311403008679 ligand binding site [chemical binding]; other site 311403008680 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403008681 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403008682 ligand binding site [chemical binding]; other site 311403008683 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403008684 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403008685 Walker A/P-loop; other site 311403008686 ATP binding site [chemical binding]; other site 311403008687 Q-loop/lid; other site 311403008688 ABC transporter signature motif; other site 311403008689 Walker B; other site 311403008690 D-loop; other site 311403008691 H-loop/switch region; other site 311403008692 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403008693 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403008694 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403008695 TM-ABC transporter signature motif; other site 311403008696 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 311403008697 active site 311403008698 DNA polymerase III subunit epsilon; Validated; Region: PRK09182 311403008699 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 311403008700 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 311403008701 type II secretion system protein D; Region: type_II_gspD; TIGR02517 311403008702 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 311403008703 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 311403008704 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 311403008705 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 311403008706 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 311403008707 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 311403008708 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 311403008709 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 311403008710 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 311403008711 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 311403008712 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 311403008713 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 311403008714 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 311403008715 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 311403008716 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 311403008717 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 311403008718 Walker A motif; other site 311403008719 ATP binding site [chemical binding]; other site 311403008720 Walker B motif; other site 311403008721 Oligomerisation domain; Region: Oligomerisation; cl00519 311403008722 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 311403008723 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 311403008724 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 311403008725 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 311403008726 ligand binding site [chemical binding]; other site 311403008727 NAD binding site [chemical binding]; other site 311403008728 tetramer interface [polypeptide binding]; other site 311403008729 catalytic site [active] 311403008730 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 311403008731 L-serine binding site [chemical binding]; other site 311403008732 ACT domain interface; other site 311403008733 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 311403008734 putative active site [active] 311403008735 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 311403008736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403008737 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403008738 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 311403008739 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403008740 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403008741 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403008742 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 311403008743 metal binding site [ion binding]; metal-binding site 311403008744 putative dimer interface [polypeptide binding]; other site 311403008745 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403008746 cyclase homology domain; Region: CHD; cd07302 311403008747 nucleotidyl binding site; other site 311403008748 metal binding site [ion binding]; metal-binding site 311403008749 dimer interface [polypeptide binding]; other site 311403008750 Protein of unknown function (DUF992); Region: DUF992; pfam06186 311403008751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403008752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403008753 putative substrate translocation pore; other site 311403008754 transaminase; Validated; Region: PRK07324 311403008755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403008756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403008757 homodimer interface [polypeptide binding]; other site 311403008758 catalytic residue [active] 311403008759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403008760 non-specific DNA binding site [nucleotide binding]; other site 311403008761 salt bridge; other site 311403008762 sequence-specific DNA binding site [nucleotide binding]; other site 311403008763 Cupin domain; Region: Cupin_2; pfam07883 311403008764 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 311403008765 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 311403008766 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 311403008767 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403008768 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 311403008769 dimerization interface [polypeptide binding]; other site 311403008770 putative DNA binding site [nucleotide binding]; other site 311403008771 putative Zn2+ binding site [ion binding]; other site 311403008772 AsnC family; Region: AsnC_trans_reg; pfam01037 311403008773 ornithine cyclodeaminase; Validated; Region: PRK07589 311403008774 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 311403008775 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 311403008776 Amidinotransferase; Region: Amidinotransf; pfam02274 311403008777 hypothetical protein; Provisional; Region: PRK06486 311403008778 intersubunit interface [polypeptide binding]; other site 311403008779 active site 311403008780 Zn2+ binding site [ion binding]; other site 311403008781 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 311403008782 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 311403008783 putative di-iron ligands [ion binding]; other site 311403008784 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403008785 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 311403008786 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403008787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403008788 dimer interface [polypeptide binding]; other site 311403008789 conserved gate region; other site 311403008790 putative PBP binding loops; other site 311403008791 ABC-ATPase subunit interface; other site 311403008792 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403008793 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 311403008794 Walker A/P-loop; other site 311403008795 ATP binding site [chemical binding]; other site 311403008796 Q-loop/lid; other site 311403008797 ABC transporter signature motif; other site 311403008798 Walker B; other site 311403008799 D-loop; other site 311403008800 H-loop/switch region; other site 311403008801 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 311403008802 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 311403008803 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 311403008804 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 311403008805 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403008806 urea carboxylase; Region: urea_carbox; TIGR02712 311403008807 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403008808 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 311403008809 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 311403008810 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 311403008811 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403008812 carboxyltransferase (CT) interaction site; other site 311403008813 biotinylation site [posttranslational modification]; other site 311403008814 allophanate hydrolase; Provisional; Region: PRK08186 311403008815 Amidase; Region: Amidase; cl11426 311403008816 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 311403008817 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403008818 protein binding site [polypeptide binding]; other site 311403008819 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 311403008820 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 311403008821 Predicted membrane protein [Function unknown]; Region: COG2259 311403008822 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403008823 PEP synthetase regulatory protein; Provisional; Region: PRK05339 311403008824 Maf-like protein; Reviewed; Region: PRK02478 311403008825 putative active site [active] 311403008826 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 311403008827 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 311403008828 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 311403008829 shikimate binding site; other site 311403008830 NAD(P) binding site [chemical binding]; other site 311403008831 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 311403008832 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 311403008833 CoA-binding site [chemical binding]; other site 311403008834 ATP-binding [chemical binding]; other site 311403008835 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 311403008836 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 311403008837 active site 311403008838 catalytic site [active] 311403008839 substrate binding site [chemical binding]; other site 311403008840 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403008841 preprotein translocase subunit SecB; Validated; Region: PRK05751 311403008842 SecA binding site; other site 311403008843 Preprotein binding site; other site 311403008844 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 311403008845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 311403008846 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 311403008847 MltA specific insert domain; Region: MltA; smart00925 311403008848 3D domain; Region: 3D; pfam06725 311403008849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 311403008850 Smr domain; Region: Smr; pfam01713 311403008851 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403008852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403008853 non-specific DNA binding site [nucleotide binding]; other site 311403008854 salt bridge; other site 311403008855 sequence-specific DNA binding site [nucleotide binding]; other site 311403008856 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 311403008857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403008858 Mg2+ binding site [ion binding]; other site 311403008859 G-X-G motif; other site 311403008860 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 311403008861 anchoring element; other site 311403008862 dimer interface [polypeptide binding]; other site 311403008863 ATP binding site [chemical binding]; other site 311403008864 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 311403008865 active site 311403008866 putative metal-binding site [ion binding]; other site 311403008867 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 311403008868 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 311403008869 putative FMN binding site [chemical binding]; other site 311403008870 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 311403008871 tyrosine decarboxylase; Region: PLN02880 311403008872 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 311403008873 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403008874 catalytic residue [active] 311403008875 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 311403008876 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403008877 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 311403008878 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 311403008879 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 311403008880 Protein of unknown function DUF45; Region: DUF45; pfam01863 311403008881 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 311403008882 active site 311403008883 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 311403008884 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 311403008885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403008886 catalytic residue [active] 311403008887 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 311403008888 substrate binding site [chemical binding]; other site 311403008889 active site 311403008890 catalytic residues [active] 311403008891 heterodimer interface [polypeptide binding]; other site 311403008892 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 311403008893 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 311403008894 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 311403008895 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 311403008896 catalytic residues [active] 311403008897 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 311403008898 Part of AAA domain; Region: AAA_19; pfam13245 311403008899 Family description; Region: UvrD_C_2; pfam13538 311403008900 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 311403008901 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 311403008902 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 311403008903 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 311403008904 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 311403008905 Substrate binding site; other site 311403008906 metal-binding site 311403008907 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 311403008908 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 311403008909 Phosphotransferase enzyme family; Region: APH; pfam01636 311403008910 PAS fold; Region: PAS_7; pfam12860 311403008911 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 311403008912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403008913 dimer interface [polypeptide binding]; other site 311403008914 phosphorylation site [posttranslational modification] 311403008915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403008916 ATP binding site [chemical binding]; other site 311403008917 Mg2+ binding site [ion binding]; other site 311403008918 G-X-G motif; other site 311403008919 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 311403008920 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 311403008921 homotetramer interface [polypeptide binding]; other site 311403008922 ligand binding site [chemical binding]; other site 311403008923 catalytic site [active] 311403008924 NAD binding site [chemical binding]; other site 311403008925 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 311403008926 dimerization domain swap beta strand [polypeptide binding]; other site 311403008927 regulatory protein interface [polypeptide binding]; other site 311403008928 active site 311403008929 regulatory phosphorylation site [posttranslational modification]; other site 311403008930 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 311403008931 active pocket/dimerization site; other site 311403008932 active site 311403008933 phosphorylation site [posttranslational modification] 311403008934 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 311403008935 Hpr binding site; other site 311403008936 homohexamer subunit interaction site [polypeptide binding]; other site 311403008937 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 311403008938 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 311403008939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 311403008940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403008941 dimerization interface [polypeptide binding]; other site 311403008942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403008943 dimer interface [polypeptide binding]; other site 311403008944 phosphorylation site [posttranslational modification] 311403008945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403008946 ATP binding site [chemical binding]; other site 311403008947 Mg2+ binding site [ion binding]; other site 311403008948 G-X-G motif; other site 311403008949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403008950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403008951 active site 311403008952 phosphorylation site [posttranslational modification] 311403008953 intermolecular recognition site; other site 311403008954 dimerization interface [polypeptide binding]; other site 311403008955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403008956 DNA binding site [nucleotide binding] 311403008957 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 311403008958 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 311403008959 active site 311403008960 substrate-binding site [chemical binding]; other site 311403008961 metal-binding site [ion binding] 311403008962 ATP binding site [chemical binding]; other site 311403008963 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 311403008964 hypothetical protein; Provisional; Region: PRK09256 311403008965 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 311403008966 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 311403008967 pantothenate kinase; Provisional; Region: PRK05439 311403008968 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 311403008969 ATP-binding site [chemical binding]; other site 311403008970 CoA-binding site [chemical binding]; other site 311403008971 Mg2+-binding site [ion binding]; other site 311403008972 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 311403008973 metal binding site [ion binding]; metal-binding site 311403008974 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 311403008975 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 311403008976 substrate binding site [chemical binding]; other site 311403008977 glutamase interaction surface [polypeptide binding]; other site 311403008978 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 311403008979 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 311403008980 catalytic residues [active] 311403008981 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 311403008982 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 311403008983 putative active site [active] 311403008984 oxyanion strand; other site 311403008985 catalytic triad [active] 311403008986 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 311403008987 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 311403008988 putative active site pocket [active] 311403008989 4-fold oligomerization interface [polypeptide binding]; other site 311403008990 metal binding residues [ion binding]; metal-binding site 311403008991 3-fold/trimer interface [polypeptide binding]; other site 311403008992 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 311403008993 active site 311403008994 HslU subunit interaction site [polypeptide binding]; other site 311403008995 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 311403008996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403008997 Walker A motif; other site 311403008998 ATP binding site [chemical binding]; other site 311403008999 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 311403009000 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 311403009001 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 311403009002 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 311403009003 Cytochrome P450; Region: p450; cl12078 311403009004 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 311403009005 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403009006 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403009007 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403009008 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 311403009009 active site 311403009010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403009011 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403009012 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 311403009013 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 311403009014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403009015 active site 311403009016 phosphorylation site [posttranslational modification] 311403009017 intermolecular recognition site; other site 311403009018 dimerization interface [polypeptide binding]; other site 311403009019 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 311403009020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403009021 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403009022 dimer interface [polypeptide binding]; other site 311403009023 phosphorylation site [posttranslational modification] 311403009024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403009025 ATP binding site [chemical binding]; other site 311403009026 Mg2+ binding site [ion binding]; other site 311403009027 G-X-G motif; other site 311403009028 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 311403009029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403009030 ATP binding site [chemical binding]; other site 311403009031 putative Mg++ binding site [ion binding]; other site 311403009032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403009033 nucleotide binding region [chemical binding]; other site 311403009034 ATP-binding site [chemical binding]; other site 311403009035 Helicase associated domain (HA2); Region: HA2; pfam04408 311403009036 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 311403009037 ornithine cyclodeaminase; Validated; Region: PRK06141 311403009038 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 311403009039 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 311403009040 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 311403009041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 311403009042 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 311403009043 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 311403009044 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 311403009045 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 311403009046 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 311403009047 haemagglutination activity domain; Region: Haemagg_act; pfam05860 311403009048 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 311403009049 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 311403009050 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 311403009051 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 311403009052 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 311403009053 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 311403009054 MafB19-like deaminase; Region: MafB19-deam; pfam14437 311403009055 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 311403009056 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 311403009057 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403009058 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403009059 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403009060 putative active site [active] 311403009061 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403009062 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403009063 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403009064 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 311403009065 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 311403009066 ligand binding site [chemical binding]; other site 311403009067 NAD binding site [chemical binding]; other site 311403009068 dimerization interface [polypeptide binding]; other site 311403009069 catalytic site [active] 311403009070 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 311403009071 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403009072 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 311403009073 tetramerization interface [polypeptide binding]; other site 311403009074 NAD(P) binding site [chemical binding]; other site 311403009075 catalytic residues [active] 311403009076 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403009077 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403009078 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403009079 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 311403009080 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403009081 dimer interface [polypeptide binding]; other site 311403009082 PYR/PP interface [polypeptide binding]; other site 311403009083 TPP binding site [chemical binding]; other site 311403009084 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 311403009085 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 311403009086 TPP-binding site [chemical binding]; other site 311403009087 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403009088 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 311403009089 short chain dehydrogenase; Provisional; Region: PRK06198 311403009090 classical (c) SDRs; Region: SDR_c; cd05233 311403009091 NAD(P) binding site [chemical binding]; other site 311403009092 active site 311403009093 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403009094 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 311403009095 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403009096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403009097 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403009098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403009099 DNA binding site [nucleotide binding] 311403009100 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 311403009101 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403009102 putative ligand binding site [chemical binding]; other site 311403009103 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403009104 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403009105 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403009106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403009107 TM-ABC transporter signature motif; other site 311403009108 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403009109 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403009110 TM-ABC transporter signature motif; other site 311403009111 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403009112 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403009113 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403009114 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 311403009115 LrgB-like family; Region: LrgB; cl00596 311403009116 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 311403009117 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 311403009118 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 311403009119 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 311403009120 DNA binding site [nucleotide binding] 311403009121 active site 311403009122 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403009123 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403009124 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403009125 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403009126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403009127 active site 311403009128 catalytic tetrad [active] 311403009129 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 311403009130 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403009131 Walker A/P-loop; other site 311403009132 ATP binding site [chemical binding]; other site 311403009133 Q-loop/lid; other site 311403009134 ABC transporter signature motif; other site 311403009135 Walker B; other site 311403009136 D-loop; other site 311403009137 H-loop/switch region; other site 311403009138 TOBE domain; Region: TOBE_2; pfam08402 311403009139 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403009140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009141 dimer interface [polypeptide binding]; other site 311403009142 conserved gate region; other site 311403009143 putative PBP binding loops; other site 311403009144 ABC-ATPase subunit interface; other site 311403009145 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403009146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009147 dimer interface [polypeptide binding]; other site 311403009148 conserved gate region; other site 311403009149 putative PBP binding loops; other site 311403009150 ABC-ATPase subunit interface; other site 311403009151 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403009152 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403009153 Cupin domain; Region: Cupin_2; pfam07883 311403009154 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403009155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403009156 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 311403009157 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403009158 Metal-binding active site; metal-binding site 311403009159 CopC domain; Region: CopC; pfam04234 311403009160 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403009161 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 311403009162 active site 311403009163 metal binding site [ion binding]; metal-binding site 311403009164 succinic semialdehyde dehydrogenase; Region: PLN02278 311403009165 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 311403009166 tetramerization interface [polypeptide binding]; other site 311403009167 NAD(P) binding site [chemical binding]; other site 311403009168 catalytic residues [active] 311403009169 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 311403009170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403009171 inhibitor-cofactor binding pocket; inhibition site 311403009172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403009173 catalytic residue [active] 311403009174 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 311403009175 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 311403009176 DNA binding residues [nucleotide binding] 311403009177 dimer interface [polypeptide binding]; other site 311403009178 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 311403009179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403009180 non-specific DNA binding site [nucleotide binding]; other site 311403009181 salt bridge; other site 311403009182 sequence-specific DNA binding site [nucleotide binding]; other site 311403009183 Cupin domain; Region: Cupin_2; pfam07883 311403009184 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 311403009185 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 311403009186 catalytic site [active] 311403009187 putative active site [active] 311403009188 putative substrate binding site [chemical binding]; other site 311403009189 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 311403009190 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 311403009191 RNA binding site [nucleotide binding]; other site 311403009192 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 311403009193 RNA binding site [nucleotide binding]; other site 311403009194 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 311403009195 RNA binding site [nucleotide binding]; other site 311403009196 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 311403009197 RNA binding site [nucleotide binding]; other site 311403009198 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 311403009199 RNA binding site [nucleotide binding]; other site 311403009200 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 311403009201 RNA binding site [nucleotide binding]; other site 311403009202 cytidylate kinase; Provisional; Region: cmk; PRK00023 311403009203 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 311403009204 CMP-binding site; other site 311403009205 The sites determining sugar specificity; other site 311403009206 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 311403009207 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 311403009208 hinge; other site 311403009209 active site 311403009210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 311403009211 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 311403009212 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 311403009213 GIY-YIG motif/motif A; other site 311403009214 putative active site [active] 311403009215 putative metal binding site [ion binding]; other site 311403009216 Predicted membrane protein [Function unknown]; Region: COG3619 311403009217 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 311403009218 Uncharacterized conserved protein [Function unknown]; Region: COG1434 311403009219 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 311403009220 putative active site [active] 311403009221 Predicted membrane protein [Function unknown]; Region: COG2860 311403009222 UPF0126 domain; Region: UPF0126; pfam03458 311403009223 UPF0126 domain; Region: UPF0126; pfam03458 311403009224 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 311403009225 metal binding site 2 [ion binding]; metal-binding site 311403009226 putative DNA binding helix; other site 311403009227 metal binding site 1 [ion binding]; metal-binding site 311403009228 dimer interface [polypeptide binding]; other site 311403009229 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 311403009230 active site 1 [active] 311403009231 dimer interface [polypeptide binding]; other site 311403009232 active site 2 [active] 311403009233 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 311403009234 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 311403009235 dimer interface [polypeptide binding]; other site 311403009236 active site 311403009237 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 311403009238 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 311403009239 NAD binding site [chemical binding]; other site 311403009240 homotetramer interface [polypeptide binding]; other site 311403009241 homodimer interface [polypeptide binding]; other site 311403009242 substrate binding site [chemical binding]; other site 311403009243 active site 311403009244 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 311403009245 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403009246 Dienelactone hydrolase family; Region: DLH; pfam01738 311403009247 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 311403009248 Methyltransferase small domain; Region: MTS; pfam05175 311403009249 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 311403009250 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 311403009251 RNase E interface [polypeptide binding]; other site 311403009252 trimer interface [polypeptide binding]; other site 311403009253 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 311403009254 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 311403009255 RNase E interface [polypeptide binding]; other site 311403009256 trimer interface [polypeptide binding]; other site 311403009257 active site 311403009258 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 311403009259 putative nucleic acid binding region [nucleotide binding]; other site 311403009260 G-X-X-G motif; other site 311403009261 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 311403009262 RNA binding site [nucleotide binding]; other site 311403009263 domain interface; other site 311403009264 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 311403009265 16S/18S rRNA binding site [nucleotide binding]; other site 311403009266 S13e-L30e interaction site [polypeptide binding]; other site 311403009267 25S rRNA binding site [nucleotide binding]; other site 311403009268 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403009269 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 311403009270 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 311403009271 RNA binding site [nucleotide binding]; other site 311403009272 active site 311403009273 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 311403009274 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 311403009275 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 311403009276 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 311403009277 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 311403009278 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 311403009279 G1 box; other site 311403009280 putative GEF interaction site [polypeptide binding]; other site 311403009281 GTP/Mg2+ binding site [chemical binding]; other site 311403009282 Switch I region; other site 311403009283 G2 box; other site 311403009284 G3 box; other site 311403009285 Switch II region; other site 311403009286 G4 box; other site 311403009287 G5 box; other site 311403009288 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 311403009289 Translation-initiation factor 2; Region: IF-2; pfam11987 311403009290 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 311403009291 hypothetical protein; Provisional; Region: PRK09190 311403009292 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 311403009293 putative RNA binding cleft [nucleotide binding]; other site 311403009294 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 311403009295 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 311403009296 NusA N-terminal domain; Region: NusA_N; pfam08529 311403009297 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 311403009298 RNA binding site [nucleotide binding]; other site 311403009299 homodimer interface [polypeptide binding]; other site 311403009300 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 311403009301 G-X-X-G motif; other site 311403009302 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 311403009303 G-X-X-G motif; other site 311403009304 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 311403009305 ribosome maturation protein RimP; Reviewed; Region: PRK00092 311403009306 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 311403009307 putative oligomer interface [polypeptide binding]; other site 311403009308 putative RNA binding site [nucleotide binding]; other site 311403009309 Transglycosylase SLT domain; Region: SLT_2; pfam13406 311403009310 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403009311 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403009312 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403009313 recombination protein RecR; Reviewed; Region: recR; PRK00076 311403009314 RecR protein; Region: RecR; pfam02132 311403009315 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 311403009316 putative active site [active] 311403009317 putative metal-binding site [ion binding]; other site 311403009318 tetramer interface [polypeptide binding]; other site 311403009319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 311403009320 MOSC domain; Region: MOSC; pfam03473 311403009321 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 311403009322 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403009323 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 311403009324 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403009325 putative DNA binding site [nucleotide binding]; other site 311403009326 putative Zn2+ binding site [ion binding]; other site 311403009327 AsnC family; Region: AsnC_trans_reg; pfam01037 311403009328 hypothetical protein; Validated; Region: PRK00153 311403009329 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 311403009330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403009331 Walker A motif; other site 311403009332 ATP binding site [chemical binding]; other site 311403009333 Walker B motif; other site 311403009334 arginine finger; other site 311403009335 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 311403009336 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 311403009337 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 311403009338 nucleotide binding site/active site [active] 311403009339 HIT family signature motif; other site 311403009340 catalytic residue [active] 311403009341 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 311403009342 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 311403009343 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 311403009344 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 311403009345 putative NADH binding site [chemical binding]; other site 311403009346 putative active site [active] 311403009347 nudix motif; other site 311403009348 putative metal binding site [ion binding]; other site 311403009349 HTH domain; Region: HTH_11; pfam08279 311403009350 Predicted transcriptional regulator [Transcription]; Region: COG2378 311403009351 WYL domain; Region: WYL; pfam13280 311403009352 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 311403009353 putative dimer interface [polypeptide binding]; other site 311403009354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403009355 prephenate dehydratase; Provisional; Region: PRK11899 311403009356 Prephenate dehydratase; Region: PDT; pfam00800 311403009357 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 311403009358 putative L-Phe binding site [chemical binding]; other site 311403009359 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 311403009360 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 311403009361 Ligand binding site; other site 311403009362 oligomer interface; other site 311403009363 Cytochrome c2 [Energy production and conversion]; Region: COG3474 311403009364 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 311403009365 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 311403009366 active site 311403009367 nucleophile elbow; other site 311403009368 Patatin phospholipase; Region: DUF3734; pfam12536 311403009369 Predicted permeases [General function prediction only]; Region: COG0679 311403009370 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 311403009371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403009372 substrate binding site [chemical binding]; other site 311403009373 ATP binding site [chemical binding]; other site 311403009374 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 311403009375 Cadmium resistance transporter; Region: Cad; pfam03596 311403009376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 311403009377 Bacterial SH3 domain; Region: SH3_4; pfam06347 311403009378 Bacterial SH3 domain; Region: SH3_4; pfam06347 311403009379 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 311403009380 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 311403009381 dimerization interface [polypeptide binding]; other site 311403009382 ligand binding site [chemical binding]; other site 311403009383 NADP binding site [chemical binding]; other site 311403009384 catalytic site [active] 311403009385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403009386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403009387 S-adenosylmethionine binding site [chemical binding]; other site 311403009388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403009389 Coenzyme A binding pocket [chemical binding]; other site 311403009390 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 311403009391 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 311403009392 ATP binding site [chemical binding]; other site 311403009393 substrate interface [chemical binding]; other site 311403009394 recombination protein F; Reviewed; Region: recF; PRK00064 311403009395 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 311403009396 Walker A/P-loop; other site 311403009397 ATP binding site [chemical binding]; other site 311403009398 Q-loop/lid; other site 311403009399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403009400 ABC transporter signature motif; other site 311403009401 Walker B; other site 311403009402 D-loop; other site 311403009403 H-loop/switch region; other site 311403009404 chaperone protein DnaJ; Provisional; Region: PRK10767 311403009405 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 311403009406 HSP70 interaction site [polypeptide binding]; other site 311403009407 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 311403009408 substrate binding site [polypeptide binding]; other site 311403009409 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 311403009410 Zn binding sites [ion binding]; other site 311403009411 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 311403009412 dimer interface [polypeptide binding]; other site 311403009413 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 311403009414 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 311403009415 nucleotide binding site [chemical binding]; other site 311403009416 NEF interaction site [polypeptide binding]; other site 311403009417 SBD interface [polypeptide binding]; other site 311403009418 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 311403009419 Transglycosylase; Region: Transgly; pfam00912 311403009420 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 311403009421 Protein of unknown function (DUF982); Region: DUF982; pfam06169 311403009422 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 311403009423 Bacterial SH3 domain; Region: SH3_3; pfam08239 311403009424 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 311403009425 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 311403009426 ATP binding site [chemical binding]; other site 311403009427 active site 311403009428 substrate binding site [chemical binding]; other site 311403009429 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403009430 active site 311403009431 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 311403009432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403009433 RNA binding surface [nucleotide binding]; other site 311403009434 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 311403009435 active site 311403009436 osmolarity response regulator; Provisional; Region: ompR; PRK09468 311403009437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403009438 active site 311403009439 phosphorylation site [posttranslational modification] 311403009440 intermolecular recognition site; other site 311403009441 dimerization interface [polypeptide binding]; other site 311403009442 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403009443 DNA binding site [nucleotide binding] 311403009444 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403009445 dimerization interface [polypeptide binding]; other site 311403009446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 311403009447 dimer interface [polypeptide binding]; other site 311403009448 phosphorylation site [posttranslational modification] 311403009449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403009450 ATP binding site [chemical binding]; other site 311403009451 Mg2+ binding site [ion binding]; other site 311403009452 G-X-G motif; other site 311403009453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 311403009454 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403009455 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403009456 dimer interface [polypeptide binding]; other site 311403009457 putative CheW interface [polypeptide binding]; other site 311403009458 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403009459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403009460 Walker A/P-loop; other site 311403009461 ATP binding site [chemical binding]; other site 311403009462 Q-loop/lid; other site 311403009463 ABC transporter signature motif; other site 311403009464 Walker B; other site 311403009465 D-loop; other site 311403009466 H-loop/switch region; other site 311403009467 TOBE domain; Region: TOBE_2; pfam08402 311403009468 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403009469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009470 dimer interface [polypeptide binding]; other site 311403009471 conserved gate region; other site 311403009472 putative PBP binding loops; other site 311403009473 ABC-ATPase subunit interface; other site 311403009474 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 311403009475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009476 dimer interface [polypeptide binding]; other site 311403009477 conserved gate region; other site 311403009478 putative PBP binding loops; other site 311403009479 ABC-ATPase subunit interface; other site 311403009480 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403009481 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 311403009482 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 311403009483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403009484 active site 311403009485 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 311403009486 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403009487 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403009488 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403009489 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 311403009490 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 311403009491 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 311403009492 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 311403009493 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 311403009494 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403009495 catalytic core [active] 311403009496 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 311403009497 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 311403009498 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 311403009499 Subunit I/III interface [polypeptide binding]; other site 311403009500 Subunit III/IV interface [polypeptide binding]; other site 311403009501 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 311403009502 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 311403009503 D-pathway; other site 311403009504 Putative ubiquinol binding site [chemical binding]; other site 311403009505 Low-spin heme (heme b) binding site [chemical binding]; other site 311403009506 Putative water exit pathway; other site 311403009507 Binuclear center (heme o3/CuB) [ion binding]; other site 311403009508 K-pathway; other site 311403009509 Putative proton exit pathway; other site 311403009510 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 311403009511 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 311403009512 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 311403009513 metabolite-proton symporter; Region: 2A0106; TIGR00883 311403009514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403009515 putative substrate translocation pore; other site 311403009516 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403009517 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 311403009518 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 311403009519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009520 dimer interface [polypeptide binding]; other site 311403009521 conserved gate region; other site 311403009522 putative PBP binding loops; other site 311403009523 ABC-ATPase subunit interface; other site 311403009524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009525 dimer interface [polypeptide binding]; other site 311403009526 conserved gate region; other site 311403009527 putative PBP binding loops; other site 311403009528 ABC-ATPase subunit interface; other site 311403009529 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403009530 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 311403009531 Walker A/P-loop; other site 311403009532 ATP binding site [chemical binding]; other site 311403009533 Q-loop/lid; other site 311403009534 ABC transporter signature motif; other site 311403009535 Walker B; other site 311403009536 D-loop; other site 311403009537 H-loop/switch region; other site 311403009538 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403009539 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 311403009540 metal binding site [ion binding]; metal-binding site 311403009541 putative dimer interface [polypeptide binding]; other site 311403009542 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 311403009543 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403009544 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 311403009545 active site 311403009546 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 311403009547 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 311403009548 active site 311403009549 hypothetical protein; Validated; Region: PRK09104 311403009550 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 311403009551 metal binding site [ion binding]; metal-binding site 311403009552 putative dimer interface [polypeptide binding]; other site 311403009553 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 311403009554 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 311403009555 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 311403009556 PAS domain S-box; Region: sensory_box; TIGR00229 311403009557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403009558 putative active site [active] 311403009559 heme pocket [chemical binding]; other site 311403009560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403009561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403009562 metal binding site [ion binding]; metal-binding site 311403009563 active site 311403009564 I-site; other site 311403009565 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403009566 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403009567 MarR family; Region: MarR; pfam01047 311403009568 DNA polymerase I; Region: pola; TIGR00593 311403009569 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 311403009570 active site 311403009571 metal binding site 1 [ion binding]; metal-binding site 311403009572 putative 5' ssDNA interaction site; other site 311403009573 metal binding site 3; metal-binding site 311403009574 metal binding site 2 [ion binding]; metal-binding site 311403009575 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 311403009576 putative DNA binding site [nucleotide binding]; other site 311403009577 putative metal binding site [ion binding]; other site 311403009578 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 311403009579 active site 311403009580 catalytic site [active] 311403009581 substrate binding site [chemical binding]; other site 311403009582 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 311403009583 active site 311403009584 DNA binding site [nucleotide binding] 311403009585 catalytic site [active] 311403009586 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 311403009587 Guanylate kinase; Region: Guanylate_kin; pfam00625 311403009588 active site 311403009589 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 311403009590 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403009591 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 311403009592 active site 311403009593 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 311403009594 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 311403009595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009596 dimer interface [polypeptide binding]; other site 311403009597 conserved gate region; other site 311403009598 ABC-ATPase subunit interface; other site 311403009599 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 311403009600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009601 dimer interface [polypeptide binding]; other site 311403009602 conserved gate region; other site 311403009603 ABC-ATPase subunit interface; other site 311403009604 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 311403009605 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 311403009606 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 311403009607 Walker A/P-loop; other site 311403009608 ATP binding site [chemical binding]; other site 311403009609 Q-loop/lid; other site 311403009610 ABC transporter signature motif; other site 311403009611 Walker B; other site 311403009612 D-loop; other site 311403009613 H-loop/switch region; other site 311403009614 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 311403009615 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 311403009616 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 311403009617 trimer interface [polypeptide binding]; other site 311403009618 active site 311403009619 substrate binding site [chemical binding]; other site 311403009620 CoA binding site [chemical binding]; other site 311403009621 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 311403009622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403009623 Walker A/P-loop; other site 311403009624 ATP binding site [chemical binding]; other site 311403009625 Q-loop/lid; other site 311403009626 ABC transporter signature motif; other site 311403009627 Walker B; other site 311403009628 D-loop; other site 311403009629 H-loop/switch region; other site 311403009630 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 311403009631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403009632 Walker A/P-loop; other site 311403009633 ATP binding site [chemical binding]; other site 311403009634 Q-loop/lid; other site 311403009635 ABC transporter signature motif; other site 311403009636 Walker B; other site 311403009637 D-loop; other site 311403009638 H-loop/switch region; other site 311403009639 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403009640 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 311403009641 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 311403009642 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 311403009643 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 311403009644 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 311403009645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403009646 DNA-binding site [nucleotide binding]; DNA binding site 311403009647 UTRA domain; Region: UTRA; pfam07702 311403009648 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403009649 catalytic core [active] 311403009650 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 311403009651 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 311403009652 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 311403009653 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403009654 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403009655 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 311403009656 Walker A/P-loop; other site 311403009657 ATP binding site [chemical binding]; other site 311403009658 Q-loop/lid; other site 311403009659 ABC transporter signature motif; other site 311403009660 Walker B; other site 311403009661 D-loop; other site 311403009662 H-loop/switch region; other site 311403009663 glucokinase; Provisional; Region: glk; PRK00292 311403009664 glucokinase, proteobacterial type; Region: glk; TIGR00749 311403009665 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 311403009666 active site 311403009667 dimer interfaces [polypeptide binding]; other site 311403009668 catalytic residues [active] 311403009669 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 311403009670 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 311403009671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403009672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403009673 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 311403009674 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 311403009675 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 311403009676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009677 dimer interface [polypeptide binding]; other site 311403009678 conserved gate region; other site 311403009679 putative PBP binding loops; other site 311403009680 ABC-ATPase subunit interface; other site 311403009681 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 311403009682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009683 dimer interface [polypeptide binding]; other site 311403009684 conserved gate region; other site 311403009685 putative PBP binding loops; other site 311403009686 ABC-ATPase subunit interface; other site 311403009687 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 311403009688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403009689 Walker A/P-loop; other site 311403009690 ATP binding site [chemical binding]; other site 311403009691 Q-loop/lid; other site 311403009692 ABC transporter signature motif; other site 311403009693 Walker B; other site 311403009694 D-loop; other site 311403009695 H-loop/switch region; other site 311403009696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403009697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403009698 Walker A/P-loop; other site 311403009699 ATP binding site [chemical binding]; other site 311403009700 Q-loop/lid; other site 311403009701 ABC transporter signature motif; other site 311403009702 Walker B; other site 311403009703 D-loop; other site 311403009704 H-loop/switch region; other site 311403009705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403009706 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 311403009707 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 311403009708 NAD binding site [chemical binding]; other site 311403009709 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 311403009710 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 311403009711 active site 311403009712 Predicted transcriptional regulator [Transcription]; Region: COG3905 311403009713 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 311403009714 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 311403009715 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 311403009716 Mechanosensitive ion channel; Region: MS_channel; pfam00924 311403009717 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403009718 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403009719 DNA binding site [nucleotide binding] 311403009720 domain linker motif; other site 311403009721 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403009722 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 311403009723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403009724 NAD(P) binding site [chemical binding]; other site 311403009725 active site 311403009726 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 311403009727 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 311403009728 FMN binding site [chemical binding]; other site 311403009729 active site 311403009730 substrate binding site [chemical binding]; other site 311403009731 catalytic residue [active] 311403009732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403009733 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 311403009734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403009735 NAD(P) binding site [chemical binding]; other site 311403009736 active site 311403009737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403009738 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403009739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403009740 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403009741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403009742 Coenzyme A binding pocket [chemical binding]; other site 311403009743 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403009744 MarR family; Region: MarR_2; pfam12802 311403009745 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 311403009746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403009747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403009748 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 311403009749 putative dimerization interface [polypeptide binding]; other site 311403009750 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 311403009751 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 311403009752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403009753 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403009754 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403009755 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403009756 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403009757 active site 311403009758 catalytic tetrad [active] 311403009759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403009760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403009761 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403009762 putative effector binding pocket; other site 311403009763 putative dimerization interface [polypeptide binding]; other site 311403009764 NIPSNAP; Region: NIPSNAP; pfam07978 311403009765 NIPSNAP; Region: NIPSNAP; pfam07978 311403009766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403009767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403009768 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 311403009769 ligand binding site [chemical binding]; other site 311403009770 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403009771 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 311403009772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403009773 Walker A/P-loop; other site 311403009774 ATP binding site [chemical binding]; other site 311403009775 Q-loop/lid; other site 311403009776 ABC transporter signature motif; other site 311403009777 Walker B; other site 311403009778 D-loop; other site 311403009779 H-loop/switch region; other site 311403009780 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403009781 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403009782 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403009783 TM-ABC transporter signature motif; other site 311403009784 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403009785 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403009786 TM-ABC transporter signature motif; other site 311403009787 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 311403009788 active site 311403009789 catalytic motif [active] 311403009790 Zn binding site [ion binding]; other site 311403009791 purine nucleoside phosphorylase; Provisional; Region: PRK08202 311403009792 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 311403009793 intersubunit interface [polypeptide binding]; other site 311403009794 active site 311403009795 catalytic residue [active] 311403009796 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 311403009797 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 311403009798 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 311403009799 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 311403009800 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 311403009801 catalytic motif [active] 311403009802 Catalytic residue [active] 311403009803 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403009804 active site 311403009805 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 311403009806 adenosine deaminase; Provisional; Region: PRK09358 311403009807 active site 311403009808 phosphopentomutase; Provisional; Region: PRK05362 311403009809 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 311403009810 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 311403009811 TadE-like protein; Region: TadE; pfam07811 311403009812 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 311403009813 TadE-like protein; Region: TadE; pfam07811 311403009814 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 311403009815 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 311403009816 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 311403009817 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 311403009818 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 311403009819 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 311403009820 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 311403009821 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 311403009822 BON domain; Region: BON; pfam04972 311403009823 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 311403009824 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 311403009825 Type IV pili component [Cell motility and secretion]; Region: COG5461 311403009826 AAA domain; Region: AAA_31; pfam13614 311403009827 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 311403009828 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 311403009829 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 311403009830 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 311403009831 ATP binding site [chemical binding]; other site 311403009832 Walker A motif; other site 311403009833 hexamer interface [polypeptide binding]; other site 311403009834 Walker B motif; other site 311403009835 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 311403009836 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 311403009837 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 311403009838 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 311403009839 LysE type translocator; Region: LysE; cl00565 311403009840 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 311403009841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403009842 TPR motif; other site 311403009843 binding surface 311403009844 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 311403009845 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 311403009846 interface (dimer of trimers) [polypeptide binding]; other site 311403009847 Substrate-binding/catalytic site; other site 311403009848 Zn-binding sites [ion binding]; other site 311403009849 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403009850 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 311403009851 NlpC/P60 family; Region: NLPC_P60; cl17555 311403009852 amidase; Provisional; Region: PRK07042 311403009853 Amidase; Region: Amidase; cl11426 311403009854 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403009855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009856 dimer interface [polypeptide binding]; other site 311403009857 conserved gate region; other site 311403009858 putative PBP binding loops; other site 311403009859 ABC-ATPase subunit interface; other site 311403009860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403009861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009862 dimer interface [polypeptide binding]; other site 311403009863 conserved gate region; other site 311403009864 putative PBP binding loops; other site 311403009865 ABC-ATPase subunit interface; other site 311403009866 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403009867 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 311403009868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403009869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403009870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403009871 dimerization interface [polypeptide binding]; other site 311403009872 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 311403009873 putative active site pocket [active] 311403009874 cleavage site 311403009875 hypothetical protein; Provisional; Region: PRK06149 311403009876 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 311403009877 active site 311403009878 substrate binding site [chemical binding]; other site 311403009879 ATP binding site [chemical binding]; other site 311403009880 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403009881 inhibitor-cofactor binding pocket; inhibition site 311403009882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403009883 catalytic residue [active] 311403009884 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 311403009885 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 311403009886 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 311403009887 putative active site [active] 311403009888 putative substrate binding site [chemical binding]; other site 311403009889 putative cosubstrate binding site; other site 311403009890 catalytic site [active] 311403009891 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 311403009892 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 311403009893 Chain length determinant protein; Region: Wzz; cl15801 311403009894 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 311403009895 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 311403009896 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 311403009897 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 311403009898 NAD(P) binding site [chemical binding]; other site 311403009899 homodimer interface [polypeptide binding]; other site 311403009900 substrate binding site [chemical binding]; other site 311403009901 active site 311403009902 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 311403009903 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403009904 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403009905 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403009906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009907 dimer interface [polypeptide binding]; other site 311403009908 conserved gate region; other site 311403009909 putative PBP binding loops; other site 311403009910 ABC-ATPase subunit interface; other site 311403009911 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403009912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403009913 dimer interface [polypeptide binding]; other site 311403009914 conserved gate region; other site 311403009915 ABC-ATPase subunit interface; other site 311403009916 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403009917 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403009918 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403009919 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403009920 Walker A/P-loop; other site 311403009921 ATP binding site [chemical binding]; other site 311403009922 Q-loop/lid; other site 311403009923 ABC transporter signature motif; other site 311403009924 Walker B; other site 311403009925 D-loop; other site 311403009926 H-loop/switch region; other site 311403009927 TOBE domain; Region: TOBE_2; pfam08402 311403009928 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 311403009929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 311403009930 dimer interface [polypeptide binding]; other site 311403009931 active site 311403009932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 311403009933 substrate binding site [chemical binding]; other site 311403009934 catalytic residue [active] 311403009935 Uncharacterized conserved protein [Function unknown]; Region: COG5476 311403009936 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 311403009937 MlrC C-terminus; Region: MlrC_C; pfam07171 311403009938 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 311403009939 homotrimer interaction site [polypeptide binding]; other site 311403009940 putative active site [active] 311403009941 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403009942 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403009943 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403009944 putative active site [active] 311403009945 short chain dehydrogenase; Provisional; Region: PRK07074 311403009946 classical (c) SDRs; Region: SDR_c; cd05233 311403009947 NAD(P) binding site [chemical binding]; other site 311403009948 active site 311403009949 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 311403009950 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 311403009951 active site 311403009952 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 311403009953 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 311403009954 active site 311403009955 substrate binding site [chemical binding]; other site 311403009956 metal binding site [ion binding]; metal-binding site 311403009957 Rdx family; Region: Rdx; cl01407 311403009958 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 311403009959 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 311403009960 catalytic triad [active] 311403009961 Uncharacterized conserved protein [Function unknown]; Region: COG3791 311403009962 GTP-binding protein LepA; Provisional; Region: PRK05433 311403009963 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 311403009964 G1 box; other site 311403009965 putative GEF interaction site [polypeptide binding]; other site 311403009966 GTP/Mg2+ binding site [chemical binding]; other site 311403009967 Switch I region; other site 311403009968 G2 box; other site 311403009969 G3 box; other site 311403009970 Switch II region; other site 311403009971 G4 box; other site 311403009972 G5 box; other site 311403009973 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 311403009974 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 311403009975 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 311403009976 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403009977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403009978 non-specific DNA binding site [nucleotide binding]; other site 311403009979 salt bridge; other site 311403009980 sequence-specific DNA binding site [nucleotide binding]; other site 311403009981 Cupin domain; Region: Cupin_2; pfam07883 311403009982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403009983 Coenzyme A binding pocket [chemical binding]; other site 311403009984 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 311403009985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403009986 motif II; other site 311403009987 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 311403009988 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 311403009989 active site 311403009990 Zn binding site [ion binding]; other site 311403009991 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 311403009992 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 311403009993 apolar tunnel; other site 311403009994 heme binding site [chemical binding]; other site 311403009995 dimerization interface [polypeptide binding]; other site 311403009996 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 311403009997 diiron binding motif [ion binding]; other site 311403009998 Uncharacterized conserved protein [Function unknown]; Region: COG1633 311403009999 CCC1-related protein family; Region: CCC1_like_1; cd02437 311403010000 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 311403010001 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403010002 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 311403010003 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 311403010004 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 311403010005 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 311403010006 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 311403010007 23S rRNA binding site [nucleotide binding]; other site 311403010008 L21 binding site [polypeptide binding]; other site 311403010009 L13 binding site [polypeptide binding]; other site 311403010010 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 311403010011 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 311403010012 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 311403010013 dimer interface [polypeptide binding]; other site 311403010014 motif 1; other site 311403010015 active site 311403010016 motif 2; other site 311403010017 motif 3; other site 311403010018 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 311403010019 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 311403010020 putative tRNA-binding site [nucleotide binding]; other site 311403010021 B3/4 domain; Region: B3_4; pfam03483 311403010022 tRNA synthetase B5 domain; Region: B5; smart00874 311403010023 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 311403010024 dimer interface [polypeptide binding]; other site 311403010025 motif 1; other site 311403010026 motif 3; other site 311403010027 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 311403010028 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 311403010029 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 311403010030 Transglycosylase; Region: Transgly; pfam00912 311403010031 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 311403010032 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 311403010033 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 311403010034 putative binding site; other site 311403010035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403010036 binding surface 311403010037 TPR motif; other site 311403010038 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 311403010039 MG2 domain; Region: A2M_N; pfam01835 311403010040 Alpha-2-macroglobulin family; Region: A2M; pfam00207 311403010041 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 311403010042 surface patch; other site 311403010043 thioester region; other site 311403010044 specificity defining residues; other site 311403010045 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403010046 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403010047 active site 311403010048 catalytic tetrad [active] 311403010049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010051 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403010052 putative effector binding pocket; other site 311403010053 putative dimerization interface [polypeptide binding]; other site 311403010054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403010055 Coenzyme A binding pocket [chemical binding]; other site 311403010056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403010057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403010058 active site 311403010059 catalytic tetrad [active] 311403010060 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 311403010061 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 311403010062 conserved cys residue [active] 311403010063 Isochorismatase family; Region: Isochorismatase; pfam00857 311403010064 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 311403010065 catalytic triad [active] 311403010066 conserved cis-peptide bond; other site 311403010067 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403010068 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403010069 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403010070 GtrA-like protein; Region: GtrA; pfam04138 311403010071 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 311403010072 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 311403010073 Ligand binding site; other site 311403010074 Putative Catalytic site; other site 311403010075 DXD motif; other site 311403010076 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 311403010077 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 311403010078 generic binding surface II; other site 311403010079 generic binding surface I; other site 311403010080 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 311403010081 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403010082 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 311403010083 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 311403010084 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 311403010085 putative deacylase active site [active] 311403010086 HicB family; Region: HicB; pfam05534 311403010087 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 311403010088 ArsC family; Region: ArsC; pfam03960 311403010089 putative catalytic residues [active] 311403010090 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403010091 MarR family; Region: MarR_2; pfam12802 311403010092 MarR family; Region: MarR_2; cl17246 311403010093 Predicted deacylase [General function prediction only]; Region: COG3608 311403010094 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 311403010095 active site 311403010096 Zn binding site [ion binding]; other site 311403010097 putative transporter; Provisional; Region: PRK12382 311403010098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403010099 putative substrate translocation pore; other site 311403010100 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 311403010101 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403010102 NADP binding site [chemical binding]; other site 311403010103 dimer interface [polypeptide binding]; other site 311403010104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403010107 dimerization interface [polypeptide binding]; other site 311403010108 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 311403010109 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 311403010110 Sulfate transporter family; Region: Sulfate_transp; pfam00916 311403010111 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 311403010112 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 311403010113 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 311403010114 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 311403010115 DNA binding site [nucleotide binding] 311403010116 active site 311403010117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010119 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403010120 putative effector binding pocket; other site 311403010121 dimerization interface [polypeptide binding]; other site 311403010122 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 311403010123 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403010124 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403010125 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403010126 short chain dehydrogenase; Provisional; Region: PRK06179 311403010127 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 311403010128 NADP binding site [chemical binding]; other site 311403010129 active site 311403010130 steroid binding site; other site 311403010131 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403010132 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 311403010133 putative NAD(P) binding site [chemical binding]; other site 311403010134 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 311403010135 active site 311403010136 SUMO-1 interface [polypeptide binding]; other site 311403010137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 311403010138 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403010139 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 311403010140 TAP-like protein; Region: Abhydrolase_4; pfam08386 311403010141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010142 S-adenosylmethionine binding site [chemical binding]; other site 311403010143 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 311403010144 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 311403010145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010147 LysR substrate binding domain; Region: LysR_substrate; pfam03466 311403010148 dimerization interface [polypeptide binding]; other site 311403010149 short chain dehydrogenase; Provisional; Region: PRK06500 311403010150 classical (c) SDRs; Region: SDR_c; cd05233 311403010151 NAD(P) binding site [chemical binding]; other site 311403010152 active site 311403010153 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 311403010154 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 311403010155 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 311403010156 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 311403010157 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403010158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403010159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403010160 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 311403010161 GMP synthase; Reviewed; Region: guaA; PRK00074 311403010162 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 311403010163 AMP/PPi binding site [chemical binding]; other site 311403010164 candidate oxyanion hole; other site 311403010165 catalytic triad [active] 311403010166 potential glutamine specificity residues [chemical binding]; other site 311403010167 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 311403010168 ATP Binding subdomain [chemical binding]; other site 311403010169 Ligand Binding sites [chemical binding]; other site 311403010170 Dimerization subdomain; other site 311403010171 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06026 311403010172 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 311403010173 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 311403010174 CoenzymeA binding site [chemical binding]; other site 311403010175 subunit interaction site [polypeptide binding]; other site 311403010176 PHB binding site; other site 311403010177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 311403010178 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 311403010179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490 311403010180 Imelysin; Region: Peptidase_M75; cl09159 311403010181 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 311403010182 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 311403010183 Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487 311403010184 HPP family; Region: HPP; pfam04982 311403010185 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 311403010186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010187 S-adenosylmethionine binding site [chemical binding]; other site 311403010188 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 311403010189 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 311403010190 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403010191 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 311403010192 putative NAD(P) binding site [chemical binding]; other site 311403010193 epoxyqueuosine reductase; Region: TIGR00276 311403010194 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 311403010195 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403010196 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 311403010197 C-terminal domain interface [polypeptide binding]; other site 311403010198 GSH binding site (G-site) [chemical binding]; other site 311403010199 dimer interface [polypeptide binding]; other site 311403010200 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 311403010201 N-terminal domain interface [polypeptide binding]; other site 311403010202 dimer interface [polypeptide binding]; other site 311403010203 substrate binding pocket (H-site) [chemical binding]; other site 311403010204 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 311403010205 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 311403010206 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 311403010207 putative NAD(P) binding site [chemical binding]; other site 311403010208 active site 311403010209 Uncharacterized conserved protein [Function unknown]; Region: COG5470 311403010210 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 311403010211 active site 311403010212 dimer interface [polypeptide binding]; other site 311403010213 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 311403010214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010215 S-adenosylmethionine binding site [chemical binding]; other site 311403010216 DNA polymerase III subunit beta; Validated; Region: PRK05643 311403010217 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 311403010218 putative DNA binding surface [nucleotide binding]; other site 311403010219 dimer interface [polypeptide binding]; other site 311403010220 beta-clamp/clamp loader binding surface; other site 311403010221 beta-clamp/translesion DNA polymerase binding surface; other site 311403010222 Predicted methyltransferases [General function prediction only]; Region: COG0313 311403010223 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 311403010224 putative SAM binding site [chemical binding]; other site 311403010225 putative homodimer interface [polypeptide binding]; other site 311403010226 hypothetical protein; Reviewed; Region: PRK12497 311403010227 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 311403010228 putative catalytic site [active] 311403010229 putative phosphate binding site [ion binding]; other site 311403010230 putative metal binding site [ion binding]; other site 311403010231 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 311403010232 glutathione synthetase; Provisional; Region: PRK05246 311403010233 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 311403010234 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 311403010235 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 311403010236 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 311403010237 dimer interface [polypeptide binding]; other site 311403010238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403010239 catalytic residue [active] 311403010240 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403010241 Isochorismatase family; Region: Isochorismatase; pfam00857 311403010242 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 311403010243 catalytic triad [active] 311403010244 conserved cis-peptide bond; other site 311403010245 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403010246 NIPSNAP; Region: NIPSNAP; pfam07978 311403010247 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 311403010248 EamA-like transporter family; Region: EamA; pfam00892 311403010249 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403010250 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 311403010251 AsnC family; Region: AsnC_trans_reg; pfam01037 311403010252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403010253 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 311403010254 trimer interface [polypeptide binding]; other site 311403010255 active site 311403010256 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 311403010257 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 311403010258 G1 box; other site 311403010259 putative GEF interaction site [polypeptide binding]; other site 311403010260 GTP/Mg2+ binding site [chemical binding]; other site 311403010261 Switch I region; other site 311403010262 G2 box; other site 311403010263 G3 box; other site 311403010264 Switch II region; other site 311403010265 G4 box; other site 311403010266 G5 box; other site 311403010267 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 311403010268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403010269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403010270 non-specific DNA binding site [nucleotide binding]; other site 311403010271 salt bridge; other site 311403010272 sequence-specific DNA binding site [nucleotide binding]; other site 311403010273 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 311403010274 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 311403010275 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 311403010276 Transcriptional regulator; Region: Rrf2; pfam02082 311403010277 Rrf2 family protein; Region: rrf2_super; TIGR00738 311403010278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403010279 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403010280 active site 311403010281 catalytic tetrad [active] 311403010282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010284 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403010285 putative effector binding pocket; other site 311403010286 putative dimerization interface [polypeptide binding]; other site 311403010287 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 311403010288 homodimer interaction site [polypeptide binding]; other site 311403010289 cofactor binding site; other site 311403010290 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 311403010291 Sulfatase; Region: Sulfatase; cl17466 311403010292 choline-sulfatase; Region: chol_sulfatase; TIGR03417 311403010293 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 311403010294 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 311403010295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010296 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403010297 dimerization interface [polypeptide binding]; other site 311403010298 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 311403010299 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 311403010300 active site 311403010301 homotetramer interface [polypeptide binding]; other site 311403010302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403010303 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 311403010304 active site 311403010305 motif I; other site 311403010306 motif II; other site 311403010307 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 311403010308 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 311403010309 putative active site [active] 311403010310 putative dimer interface [polypeptide binding]; other site 311403010311 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 311403010312 Flavoprotein; Region: Flavoprotein; pfam02441 311403010313 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 311403010314 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 311403010315 short chain dehydrogenase; Provisional; Region: PRK07478 311403010316 classical (c) SDRs; Region: SDR_c; cd05233 311403010317 NAD(P) binding site [chemical binding]; other site 311403010318 active site 311403010319 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010320 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010321 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403010322 putative effector binding pocket; other site 311403010323 dimerization interface [polypeptide binding]; other site 311403010324 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 311403010325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010326 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 311403010327 putative dimerization interface [polypeptide binding]; other site 311403010328 putative substrate binding pocket [chemical binding]; other site 311403010329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403010330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403010331 putative substrate translocation pore; other site 311403010332 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 311403010333 dimer interface [polypeptide binding]; other site 311403010334 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403010335 metal binding site [ion binding]; metal-binding site 311403010336 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 311403010337 oligomeric interface; other site 311403010338 putative active site [active] 311403010339 homodimer interface [polypeptide binding]; other site 311403010340 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 311403010341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010342 S-adenosylmethionine binding site [chemical binding]; other site 311403010343 urocanate hydratase; Provisional; Region: PRK05414 311403010344 Protein of unknown function (DUF917); Region: DUF917; pfam06032 311403010345 allantoate amidohydrolase; Reviewed; Region: PRK12893 311403010346 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 311403010347 active site 311403010348 metal binding site [ion binding]; metal-binding site 311403010349 dimer interface [polypeptide binding]; other site 311403010350 allantoinase; Region: allantoinase; TIGR03178 311403010351 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403010352 active site 311403010353 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 311403010354 active sites [active] 311403010355 tetramer interface [polypeptide binding]; other site 311403010356 Cupin domain; Region: Cupin_2; cl17218 311403010357 ABC1 family; Region: ABC1; cl17513 311403010358 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 311403010359 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 311403010360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010361 S-adenosylmethionine binding site [chemical binding]; other site 311403010362 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 311403010363 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 311403010364 DNA binding site [nucleotide binding] 311403010365 putative catalytic residues [active] 311403010366 turnover-facilitating residue; other site 311403010367 intercalation triad [nucleotide binding]; other site 311403010368 8OG recognition residue [nucleotide binding]; other site 311403010369 putative reading head residues; other site 311403010370 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 311403010371 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 311403010372 enoyl-CoA hydratase; Provisional; Region: PRK05862 311403010373 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403010374 substrate binding site [chemical binding]; other site 311403010375 oxyanion hole (OAH) forming residues; other site 311403010376 trimer interface [polypeptide binding]; other site 311403010377 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 311403010378 DnaA N-terminal domain; Region: DnaA_N; pfam11638 311403010379 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 311403010380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403010381 Walker A motif; other site 311403010382 ATP binding site [chemical binding]; other site 311403010383 Walker B motif; other site 311403010384 arginine finger; other site 311403010385 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 311403010386 DnaA box-binding interface [nucleotide binding]; other site 311403010387 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 311403010388 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403010389 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403010390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010391 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403010392 dimerization interface [polypeptide binding]; other site 311403010393 substrate binding pocket [chemical binding]; other site 311403010394 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 311403010395 EamA-like transporter family; Region: EamA; pfam00892 311403010396 EamA-like transporter family; Region: EamA; pfam00892 311403010397 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 311403010398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403010399 FeS/SAM binding site; other site 311403010400 HemN C-terminal domain; Region: HemN_C; pfam06969 311403010401 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 311403010402 active site 311403010403 dimerization interface [polypeptide binding]; other site 311403010404 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403010405 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 311403010406 putative metal binding site [ion binding]; other site 311403010407 ribonuclease PH; Reviewed; Region: rph; PRK00173 311403010408 Ribonuclease PH; Region: RNase_PH_bact; cd11362 311403010409 hexamer interface [polypeptide binding]; other site 311403010410 active site 311403010411 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 311403010412 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 311403010413 heat shock protein GrpE; Provisional; Region: PRK14141 311403010414 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 311403010415 dimer interface [polypeptide binding]; other site 311403010416 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 311403010417 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 311403010418 active site 311403010419 phosphorylation site [posttranslational modification] 311403010420 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 311403010421 30S subunit binding site; other site 311403010422 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 311403010423 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 311403010424 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 311403010425 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 311403010426 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 311403010427 Walker A/P-loop; other site 311403010428 ATP binding site [chemical binding]; other site 311403010429 Q-loop/lid; other site 311403010430 ABC transporter signature motif; other site 311403010431 Walker B; other site 311403010432 D-loop; other site 311403010433 H-loop/switch region; other site 311403010434 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 311403010435 OstA-like protein; Region: OstA; pfam03968 311403010436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 311403010437 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 311403010438 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 311403010439 tandem repeat interface [polypeptide binding]; other site 311403010440 oligomer interface [polypeptide binding]; other site 311403010441 active site residues [active] 311403010442 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 311403010443 IHF dimer interface [polypeptide binding]; other site 311403010444 IHF - DNA interface [nucleotide binding]; other site 311403010445 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 311403010446 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 311403010447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403010448 putative active site [active] 311403010449 heme pocket [chemical binding]; other site 311403010450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403010451 putative active site [active] 311403010452 heme pocket [chemical binding]; other site 311403010453 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403010454 dimer interface [polypeptide binding]; other site 311403010455 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 311403010456 putative CheW interface [polypeptide binding]; other site 311403010457 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403010458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403010459 Coenzyme A binding pocket [chemical binding]; other site 311403010460 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 311403010461 putative hydrophobic ligand binding site [chemical binding]; other site 311403010462 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 311403010463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010464 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 311403010465 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 311403010466 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 311403010467 lipoprotein signal peptidase; Provisional; Region: PRK14795 311403010468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403010469 dimer interface [polypeptide binding]; other site 311403010470 phosphorylation site [posttranslational modification] 311403010471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403010472 ATP binding site [chemical binding]; other site 311403010473 Mg2+ binding site [ion binding]; other site 311403010474 G-X-G motif; other site 311403010475 Response regulator receiver domain; Region: Response_reg; pfam00072 311403010476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403010477 active site 311403010478 phosphorylation site [posttranslational modification] 311403010479 intermolecular recognition site; other site 311403010480 dimerization interface [polypeptide binding]; other site 311403010481 Putative hemolysin [General function prediction only]; Region: COG3176 311403010482 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403010483 cyclase homology domain; Region: CHD; cd07302 311403010484 nucleotidyl binding site; other site 311403010485 metal binding site [ion binding]; metal-binding site 311403010486 dimer interface [polypeptide binding]; other site 311403010487 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 311403010488 Malic enzyme, N-terminal domain; Region: malic; pfam00390 311403010489 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 311403010490 putative NAD(P) binding site [chemical binding]; other site 311403010491 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 311403010492 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 311403010493 MutS domain I; Region: MutS_I; pfam01624 311403010494 MutS domain II; Region: MutS_II; pfam05188 311403010495 MutS domain III; Region: MutS_III; pfam05192 311403010496 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 311403010497 Walker A/P-loop; other site 311403010498 ATP binding site [chemical binding]; other site 311403010499 Q-loop/lid; other site 311403010500 ABC transporter signature motif; other site 311403010501 Walker B; other site 311403010502 D-loop; other site 311403010503 H-loop/switch region; other site 311403010504 PII uridylyl-transferase; Provisional; Region: PRK05092 311403010505 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 311403010506 metal binding triad; other site 311403010507 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 311403010508 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 311403010509 Zn2+ binding site [ion binding]; other site 311403010510 Mg2+ binding site [ion binding]; other site 311403010511 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 311403010512 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 311403010513 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 311403010514 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 311403010515 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 311403010516 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 311403010517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403010518 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 311403010519 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 311403010520 active site 311403010521 HIGH motif; other site 311403010522 dimer interface [polypeptide binding]; other site 311403010523 KMSKS motif; other site 311403010524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 311403010525 Ligand Binding Site [chemical binding]; other site 311403010526 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 311403010527 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 311403010528 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 311403010529 Glycoprotease family; Region: Peptidase_M22; pfam00814 311403010530 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 311403010531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403010532 Coenzyme A binding pocket [chemical binding]; other site 311403010533 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 311403010534 metal binding site 2 [ion binding]; metal-binding site 311403010535 putative DNA binding helix; other site 311403010536 metal binding site 1 [ion binding]; metal-binding site 311403010537 dimer interface [polypeptide binding]; other site 311403010538 structural Zn2+ binding site [ion binding]; other site 311403010539 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 311403010540 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 311403010541 putative acyl-acceptor binding pocket; other site 311403010542 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 311403010543 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 311403010544 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403010545 FeS/SAM binding site; other site 311403010546 TRAM domain; Region: TRAM; pfam01938 311403010547 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 311403010548 PhoH-like protein; Region: PhoH; pfam02562 311403010549 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 311403010550 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 311403010551 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 311403010552 Transporter associated domain; Region: CorC_HlyC; smart01091 311403010553 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 311403010554 Protein of unknown function (DUF989); Region: DUF989; pfam06181 311403010555 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 311403010556 putative active site [active] 311403010557 catalytic triad [active] 311403010558 putative dimer interface [polypeptide binding]; other site 311403010559 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403010560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403010561 non-specific DNA binding site [nucleotide binding]; other site 311403010562 salt bridge; other site 311403010563 sequence-specific DNA binding site [nucleotide binding]; other site 311403010564 S-adenosylmethionine synthetase; Validated; Region: PRK05250 311403010565 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 311403010566 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 311403010567 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 311403010568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010569 S-adenosylmethionine binding site [chemical binding]; other site 311403010570 Uncharacterized small protein [Function unknown]; Region: COG5568 311403010571 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 311403010572 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 311403010573 putative dimer interface [polypeptide binding]; other site 311403010574 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 311403010575 active site 311403010576 tetramer interface [polypeptide binding]; other site 311403010577 Cache domain; Region: Cache_1; pfam02743 311403010578 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 311403010579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 311403010580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403010581 dimer interface [polypeptide binding]; other site 311403010582 putative CheW interface [polypeptide binding]; other site 311403010583 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403010584 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 311403010585 substrate binding site [chemical binding]; other site 311403010586 dimer interface [polypeptide binding]; other site 311403010587 ATP binding site [chemical binding]; other site 311403010588 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 311403010589 RmuC family; Region: RmuC; pfam02646 311403010590 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 311403010591 active site 311403010592 catalytic residues [active] 311403010593 metal binding site [ion binding]; metal-binding site 311403010594 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 311403010595 oligomeric interface; other site 311403010596 putative active site [active] 311403010597 homodimer interface [polypeptide binding]; other site 311403010598 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 311403010599 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 311403010600 putative active site [active] 311403010601 substrate binding site [chemical binding]; other site 311403010602 putative cosubstrate binding site; other site 311403010603 catalytic site [active] 311403010604 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 311403010605 substrate binding site [chemical binding]; other site 311403010606 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 311403010607 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 311403010608 dimerization interface 3.5A [polypeptide binding]; other site 311403010609 active site 311403010610 malate:quinone oxidoreductase; Validated; Region: PRK05257 311403010611 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 311403010612 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 311403010613 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 311403010614 metal binding site [ion binding]; metal-binding site 311403010615 dimer interface [polypeptide binding]; other site 311403010616 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 311403010617 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 311403010618 trimer interface [polypeptide binding]; other site 311403010619 active site 311403010620 substrate binding site [chemical binding]; other site 311403010621 CoA binding site [chemical binding]; other site 311403010622 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 311403010623 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 311403010624 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 311403010625 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 311403010626 tetramer interface [polypeptide binding]; other site 311403010627 active site 311403010628 Mg2+/Mn2+ binding site [ion binding]; other site 311403010629 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 311403010630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010631 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 311403010632 putative dimerization interface [polypeptide binding]; other site 311403010633 putative substrate binding pocket [chemical binding]; other site 311403010634 short chain dehydrogenase; Provisional; Region: PRK06180 311403010635 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 311403010636 NADP binding site [chemical binding]; other site 311403010637 active site 311403010638 steroid binding site; other site 311403010639 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 311403010640 homohexameric interface [polypeptide binding]; other site 311403010641 feedback inhibition sensing region; other site 311403010642 carbamate kinase; Reviewed; Region: PRK12686 311403010643 nucleotide binding site [chemical binding]; other site 311403010644 N-acetyl-L-glutamate binding site [chemical binding]; other site 311403010645 RNA polymerase sigma factor; Provisional; Region: PRK12514 311403010646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403010647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403010648 DNA binding residues [nucleotide binding] 311403010649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 311403010650 Anti-sigma-K factor rskA; Region: RskA; pfam10099 311403010651 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 311403010652 Fasciclin domain; Region: Fasciclin; pfam02469 311403010653 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 311403010654 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 311403010655 G1 box; other site 311403010656 GTP/Mg2+ binding site [chemical binding]; other site 311403010657 Switch I region; other site 311403010658 G2 box; other site 311403010659 G3 box; other site 311403010660 Switch II region; other site 311403010661 G4 box; other site 311403010662 G5 box; other site 311403010663 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403010664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403010665 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 311403010666 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 311403010667 membrane protein insertase; Provisional; Region: PRK01318 311403010668 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 311403010669 ribonuclease P; Reviewed; Region: rnpA; PRK01313 311403010670 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 311403010671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403010672 dimerization interface [polypeptide binding]; other site 311403010673 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403010674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403010675 dimer interface [polypeptide binding]; other site 311403010676 putative CheW interface [polypeptide binding]; other site 311403010677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403010678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403010679 ATP binding site [chemical binding]; other site 311403010680 Mg2+ binding site [ion binding]; other site 311403010681 G-X-G motif; other site 311403010682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 311403010683 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 311403010684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403010685 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403010686 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403010687 GSCFA family; Region: GSCFA; pfam08885 311403010688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403010689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403010690 putative substrate translocation pore; other site 311403010691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403010692 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403010693 MarR family; Region: MarR_2; pfam12802 311403010694 BA14K-like protein; Region: BA14K; pfam07886 311403010695 short chain dehydrogenase; Provisional; Region: PRK06197 311403010696 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 311403010697 putative NAD(P) binding site [chemical binding]; other site 311403010698 active site 311403010699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010700 S-adenosylmethionine binding site [chemical binding]; other site 311403010701 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 311403010702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403010703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010705 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403010706 putative effector binding pocket; other site 311403010707 putative dimerization interface [polypeptide binding]; other site 311403010708 short chain dehydrogenase; Provisional; Region: PRK06180 311403010709 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 311403010710 NADP binding site [chemical binding]; other site 311403010711 active site 311403010712 steroid binding site; other site 311403010713 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403010714 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403010715 active site 311403010716 catalytic tetrad [active] 311403010717 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 311403010718 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 311403010719 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 311403010720 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 311403010721 putative NAD(P) binding site [chemical binding]; other site 311403010722 putative active site [active] 311403010723 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 311403010724 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 311403010725 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 311403010726 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 311403010727 non-specific DNA interactions [nucleotide binding]; other site 311403010728 DNA binding site [nucleotide binding] 311403010729 sequence specific DNA binding site [nucleotide binding]; other site 311403010730 putative cAMP binding site [chemical binding]; other site 311403010731 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403010732 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 311403010733 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403010734 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403010735 ligand binding site [chemical binding]; other site 311403010736 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403010737 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403010738 TM-ABC transporter signature motif; other site 311403010739 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403010740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403010741 Walker A/P-loop; other site 311403010742 ATP binding site [chemical binding]; other site 311403010743 Q-loop/lid; other site 311403010744 ABC transporter signature motif; other site 311403010745 Walker B; other site 311403010746 D-loop; other site 311403010747 H-loop/switch region; other site 311403010748 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 311403010749 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 311403010750 active site 311403010751 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 311403010752 active site 311403010753 substrate binding pocket [chemical binding]; other site 311403010754 dimer interface [polypeptide binding]; other site 311403010755 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 311403010756 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403010757 active site 311403010758 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 311403010759 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403010760 putative substrate binding site [chemical binding]; other site 311403010761 putative ATP binding site [chemical binding]; other site 311403010762 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 311403010763 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 311403010764 active site 311403010765 dimer interface [polypeptide binding]; other site 311403010766 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 311403010767 dimer interface [polypeptide binding]; other site 311403010768 active site 311403010769 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 311403010770 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 311403010771 acyl-activating enzyme (AAE) consensus motif; other site 311403010772 putative AMP binding site [chemical binding]; other site 311403010773 putative active site [active] 311403010774 putative CoA binding site [chemical binding]; other site 311403010775 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 311403010776 dimer interface [polypeptide binding]; other site 311403010777 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403010778 active site 311403010779 metal binding site [ion binding]; metal-binding site 311403010780 glutathione binding site [chemical binding]; other site 311403010781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 311403010782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403010783 dimer interface [polypeptide binding]; other site 311403010784 conserved gate region; other site 311403010785 putative PBP binding loops; other site 311403010786 ABC-ATPase subunit interface; other site 311403010787 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 311403010788 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403010789 Walker A/P-loop; other site 311403010790 ATP binding site [chemical binding]; other site 311403010791 Q-loop/lid; other site 311403010792 ABC transporter signature motif; other site 311403010793 Walker B; other site 311403010794 D-loop; other site 311403010795 H-loop/switch region; other site 311403010796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403010797 ABC-ATPase subunit interface; other site 311403010798 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 311403010799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010802 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403010804 dimerization interface [polypeptide binding]; other site 311403010805 Uncharacterized conserved protein [Function unknown]; Region: COG1359 311403010806 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 311403010807 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 311403010808 FMN binding site [chemical binding]; other site 311403010809 substrate binding site [chemical binding]; other site 311403010810 putative catalytic residue [active] 311403010811 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 311403010812 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 311403010813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403010814 dimer interface [polypeptide binding]; other site 311403010815 phosphorylation site [posttranslational modification] 311403010816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403010817 ATP binding site [chemical binding]; other site 311403010818 Mg2+ binding site [ion binding]; other site 311403010819 G-X-G motif; other site 311403010820 PBP superfamily domain; Region: PBP_like_2; pfam12849 311403010821 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 311403010822 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 311403010823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403010824 dimer interface [polypeptide binding]; other site 311403010825 conserved gate region; other site 311403010826 putative PBP binding loops; other site 311403010827 ABC-ATPase subunit interface; other site 311403010828 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 311403010829 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 311403010830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403010831 dimer interface [polypeptide binding]; other site 311403010832 conserved gate region; other site 311403010833 putative PBP binding loops; other site 311403010834 ABC-ATPase subunit interface; other site 311403010835 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 311403010836 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 311403010837 Walker A/P-loop; other site 311403010838 ATP binding site [chemical binding]; other site 311403010839 Q-loop/lid; other site 311403010840 ABC transporter signature motif; other site 311403010841 Walker B; other site 311403010842 D-loop; other site 311403010843 H-loop/switch region; other site 311403010844 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 311403010845 PhoU domain; Region: PhoU; pfam01895 311403010846 PhoU domain; Region: PhoU; pfam01895 311403010847 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 311403010848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403010849 active site 311403010850 phosphorylation site [posttranslational modification] 311403010851 intermolecular recognition site; other site 311403010852 dimerization interface [polypeptide binding]; other site 311403010853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403010854 DNA binding site [nucleotide binding] 311403010855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5352 311403010856 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 311403010857 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403010858 inhibitor-cofactor binding pocket; inhibition site 311403010859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403010860 catalytic residue [active] 311403010861 ornithine carbamoyltransferase; Provisional; Region: PRK00779 311403010862 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 311403010863 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 311403010864 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 311403010865 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 311403010866 dimerization interface [polypeptide binding]; other site 311403010867 domain crossover interface; other site 311403010868 redox-dependent activation switch; other site 311403010869 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 311403010870 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 311403010871 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 311403010872 homodimer interface [polypeptide binding]; other site 311403010873 substrate-cofactor binding pocket; other site 311403010874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403010875 catalytic residue [active] 311403010876 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 311403010877 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 311403010878 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 311403010879 trimer interface [polypeptide binding]; other site 311403010880 active site 311403010881 Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717 311403010882 trimer interface [polypeptide binding]; other site 311403010883 active site 311403010884 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 311403010885 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 311403010886 putative trimer interface [polypeptide binding]; other site 311403010887 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 311403010888 trimer interface [polypeptide binding]; other site 311403010889 active site 311403010890 substrate binding site [chemical binding]; other site 311403010891 putative CoA binding site [chemical binding]; other site 311403010892 CoA binding site [chemical binding]; other site 311403010893 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403010894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403010895 substrate binding pocket [chemical binding]; other site 311403010896 membrane-bound complex binding site; other site 311403010897 hinge residues; other site 311403010898 tellurite resistance protein terB; Region: terB; cd07176 311403010899 putative metal binding site [ion binding]; other site 311403010900 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 311403010901 Predicted transcriptional regulator [Transcription]; Region: COG2932 311403010902 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 311403010903 Catalytic site [active] 311403010904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 311403010905 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 311403010906 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 311403010907 quinone interaction residues [chemical binding]; other site 311403010908 active site 311403010909 catalytic residues [active] 311403010910 FMN binding site [chemical binding]; other site 311403010911 substrate binding site [chemical binding]; other site 311403010912 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 311403010913 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 311403010914 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 311403010915 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 311403010916 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 311403010917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403010918 S-adenosylmethionine binding site [chemical binding]; other site 311403010919 Uncharacterized conserved protein [Function unknown]; Region: COG1284 311403010920 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 311403010921 glutamine synthetase; Region: PLN02284 311403010922 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 311403010923 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 311403010924 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 311403010925 Uncharacterized conserved protein [Function unknown]; Region: COG2128 311403010926 Predicted transcriptional regulator [Transcription]; Region: COG1959 311403010927 Transcriptional regulator; Region: Rrf2; pfam02082 311403010928 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 311403010929 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403010930 ATP binding site [chemical binding]; other site 311403010931 putative Mg++ binding site [ion binding]; other site 311403010932 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403010933 nucleotide binding region [chemical binding]; other site 311403010934 ATP-binding site [chemical binding]; other site 311403010935 DEAD/H associated; Region: DEAD_assoc; pfam08494 311403010936 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403010937 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 311403010938 putative active site [active] 311403010939 putative metal binding site [ion binding]; other site 311403010940 RibD C-terminal domain; Region: RibD_C; cl17279 311403010941 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 311403010942 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403010943 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403010944 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 311403010945 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 311403010946 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403010947 Sel1-like repeats; Region: SEL1; smart00671 311403010948 Sel1-like repeats; Region: SEL1; smart00671 311403010949 Sel1-like repeats; Region: SEL1; smart00671 311403010950 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 311403010951 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403010952 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 311403010953 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 311403010954 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 311403010955 FAD binding site [chemical binding]; other site 311403010956 substrate binding site [chemical binding]; other site 311403010957 catalytic residues [active] 311403010958 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 311403010959 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 311403010960 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 311403010961 dimer interface [polypeptide binding]; other site 311403010962 active site 311403010963 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 311403010964 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403010965 substrate binding site [chemical binding]; other site 311403010966 oxyanion hole (OAH) forming residues; other site 311403010967 trimer interface [polypeptide binding]; other site 311403010968 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 311403010969 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 311403010970 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 311403010971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403010972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403010973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403010974 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 311403010975 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 311403010976 aspartate aminotransferase; Provisional; Region: PRK06108 311403010977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403010978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403010979 homodimer interface [polypeptide binding]; other site 311403010980 catalytic residue [active] 311403010981 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 311403010982 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 311403010983 NAD binding site [chemical binding]; other site 311403010984 homodimer interface [polypeptide binding]; other site 311403010985 active site 311403010986 substrate binding site [chemical binding]; other site 311403010987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403010988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403010989 LysR substrate binding domain; Region: LysR_substrate; pfam03466 311403010990 dimerization interface [polypeptide binding]; other site 311403010991 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403010992 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 311403010993 putative ligand binding site [chemical binding]; other site 311403010994 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403010995 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403010996 Walker A/P-loop; other site 311403010997 ATP binding site [chemical binding]; other site 311403010998 Q-loop/lid; other site 311403010999 ABC transporter signature motif; other site 311403011000 Walker B; other site 311403011001 D-loop; other site 311403011002 H-loop/switch region; other site 311403011003 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403011004 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403011005 Walker A/P-loop; other site 311403011006 ATP binding site [chemical binding]; other site 311403011007 Q-loop/lid; other site 311403011008 ABC transporter signature motif; other site 311403011009 Walker B; other site 311403011010 D-loop; other site 311403011011 H-loop/switch region; other site 311403011012 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403011013 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403011014 TM-ABC transporter signature motif; other site 311403011015 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403011016 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403011017 TM-ABC transporter signature motif; other site 311403011018 choline dehydrogenase; Validated; Region: PRK02106 311403011019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403011020 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403011021 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 311403011022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403011023 substrate binding site [chemical binding]; other site 311403011024 oxyanion hole (OAH) forming residues; other site 311403011025 trimer interface [polypeptide binding]; other site 311403011026 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 311403011027 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 311403011028 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 311403011029 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 311403011030 Part of AAA domain; Region: AAA_19; pfam13245 311403011031 Family description; Region: UvrD_C_2; pfam13538 311403011032 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 311403011033 Strictosidine synthase; Region: Str_synth; pfam03088 311403011034 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 311403011035 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 311403011036 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 311403011037 Protein export membrane protein; Region: SecD_SecF; pfam02355 311403011038 putative cation:proton antiport protein; Provisional; Region: PRK10669 311403011039 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 311403011040 TrkA-N domain; Region: TrkA_N; pfam02254 311403011041 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 311403011042 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 311403011043 heme-binding site [chemical binding]; other site 311403011044 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403011045 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403011046 dimer interface [polypeptide binding]; other site 311403011047 putative CheW interface [polypeptide binding]; other site 311403011048 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 311403011049 anti sigma factor interaction site; other site 311403011050 regulatory phosphorylation site [posttranslational modification]; other site 311403011051 Response regulator receiver domain; Region: Response_reg; pfam00072 311403011052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403011053 active site 311403011054 phosphorylation site [posttranslational modification] 311403011055 intermolecular recognition site; other site 311403011056 dimerization interface [polypeptide binding]; other site 311403011057 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 311403011058 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 311403011059 putative binding surface; other site 311403011060 active site 311403011061 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 311403011062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403011063 ATP binding site [chemical binding]; other site 311403011064 Mg2+ binding site [ion binding]; other site 311403011065 G-X-G motif; other site 311403011066 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 311403011067 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 311403011068 putative CheA interaction surface; other site 311403011069 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 311403011070 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 311403011071 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 311403011072 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 311403011073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403011074 active site 311403011075 phosphorylation site [posttranslational modification] 311403011076 intermolecular recognition site; other site 311403011077 dimerization interface [polypeptide binding]; other site 311403011078 CheB methylesterase; Region: CheB_methylest; pfam01339 311403011079 Response regulator receiver domain; Region: Response_reg; pfam00072 311403011080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403011081 active site 311403011082 phosphorylation site [posttranslational modification] 311403011083 intermolecular recognition site; other site 311403011084 dimerization interface [polypeptide binding]; other site 311403011085 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497 311403011086 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 311403011087 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 311403011088 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 311403011089 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403011090 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403011091 DNA binding residues [nucleotide binding] 311403011092 dimerization interface [polypeptide binding]; other site 311403011093 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403011094 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403011095 DNA binding residues [nucleotide binding] 311403011096 dimerization interface [polypeptide binding]; other site 311403011097 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 311403011098 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 311403011099 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 311403011100 FliG C-terminal domain; Region: FliG_C; pfam01706 311403011101 flagellar motor switch protein FliN; Region: fliN; TIGR02480 311403011102 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 311403011103 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 311403011104 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 311403011105 flagellar motor protein MotA; Validated; Region: PRK09110 311403011106 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642 311403011107 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 311403011108 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 311403011109 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002 311403011110 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 311403011111 Walker A motif; other site 311403011112 ATP binding site [chemical binding]; other site 311403011113 Walker B motif; other site 311403011114 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003 311403011115 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782 311403011116 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 311403011117 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 311403011118 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 311403011119 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 311403011120 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 311403011121 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 311403011122 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 311403011123 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 311403011124 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 311403011125 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 311403011126 Uncharacterized conserved protein [Function unknown]; Region: COG3334 311403011127 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 311403011128 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 311403011129 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 311403011130 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 311403011131 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403011132 flagellin; Reviewed; Region: PRK12687 311403011133 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 311403011134 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 311403011135 flagellin; Reviewed; Region: PRK12687 311403011136 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 311403011137 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 311403011138 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 311403011139 tyrosine decarboxylase; Region: PLN02880 311403011140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 311403011141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403011142 catalytic residue [active] 311403011143 flagellin; Reviewed; Region: PRK12687 311403011144 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 311403011145 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 311403011146 flagellin; Reviewed; Region: PRK12687 311403011147 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 311403011148 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 311403011149 flagellar motor protein MotB; Validated; Region: motB; PRK05996 311403011150 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 311403011151 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 311403011152 ligand binding site [chemical binding]; other site 311403011153 chemotaxis protein; Reviewed; Region: PRK12798 311403011154 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 311403011155 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 311403011156 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403011157 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403011158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403011159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 311403011160 active site 311403011161 dimerization interface [polypeptide binding]; other site 311403011162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403011163 DNA binding site [nucleotide binding] 311403011164 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 311403011165 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 311403011166 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 311403011167 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 311403011168 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 311403011169 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 311403011170 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 311403011171 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 311403011172 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 311403011173 Flagellar biosynthesis regulator FlaF [Cell motility and secretion]; Region: FlaF; COG5442 311403011174 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793 311403011175 Flagellar protein FlbT; Region: FlbT; cl11455 311403011176 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009 311403011177 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 311403011178 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 311403011179 flagellar biosynthesis protein FlhA; Reviewed; Region: flhA; PRK12792 311403011180 FHIPEP family; Region: FHIPEP; pfam00771 311403011181 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 311403011182 Rod binding protein; Region: Rod-binding; pfam10135 311403011183 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 311403011184 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 311403011185 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 311403011186 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 311403011187 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 311403011188 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 311403011189 homodimer interface [polypeptide binding]; other site 311403011190 NADP binding site [chemical binding]; other site 311403011191 substrate binding site [chemical binding]; other site 311403011192 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403011193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403011194 DNA binding site [nucleotide binding] 311403011195 domain linker motif; other site 311403011196 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 311403011197 ligand binding site [chemical binding]; other site 311403011198 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403011199 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403011200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403011201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403011202 dimer interface [polypeptide binding]; other site 311403011203 putative PBP binding loops; other site 311403011204 ABC-ATPase subunit interface; other site 311403011205 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403011206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403011207 dimer interface [polypeptide binding]; other site 311403011208 conserved gate region; other site 311403011209 putative PBP binding loops; other site 311403011210 ABC-ATPase subunit interface; other site 311403011211 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 311403011212 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 311403011213 active site 311403011214 catalytic site [active] 311403011215 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 311403011216 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403011217 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403011218 Walker A/P-loop; other site 311403011219 ATP binding site [chemical binding]; other site 311403011220 Q-loop/lid; other site 311403011221 ABC transporter signature motif; other site 311403011222 Walker B; other site 311403011223 D-loop; other site 311403011224 H-loop/switch region; other site 311403011225 TOBE domain; Region: TOBE_2; pfam08402 311403011226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403011227 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 311403011228 6-phosphogluconate dehydratase; Region: edd; TIGR01196 311403011229 phosphogluconate dehydratase; Validated; Region: PRK09054 311403011230 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 311403011231 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 311403011232 putative active site [active] 311403011233 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 311403011234 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 311403011235 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 311403011236 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403011237 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403011238 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 311403011239 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 311403011240 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 311403011241 Predicted flavoproteins [General function prediction only]; Region: COG2081 311403011242 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 311403011243 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 311403011244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403011245 dimerization interface [polypeptide binding]; other site 311403011246 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403011247 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403011248 dimer interface [polypeptide binding]; other site 311403011249 putative CheW interface [polypeptide binding]; other site 311403011250 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403011251 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011252 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403011253 Paired amphipathic helix repeat; Region: PAH; pfam02671 311403011254 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 311403011255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403011256 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403011257 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 311403011258 Walker A/P-loop; other site 311403011259 ATP binding site [chemical binding]; other site 311403011260 Q-loop/lid; other site 311403011261 ABC transporter signature motif; other site 311403011262 Walker B; other site 311403011263 D-loop; other site 311403011264 H-loop/switch region; other site 311403011265 TOBE domain; Region: TOBE_2; pfam08402 311403011266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403011267 dimer interface [polypeptide binding]; other site 311403011268 conserved gate region; other site 311403011269 putative PBP binding loops; other site 311403011270 ABC-ATPase subunit interface; other site 311403011271 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403011272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403011273 dimer interface [polypeptide binding]; other site 311403011274 conserved gate region; other site 311403011275 putative PBP binding loops; other site 311403011276 ABC-ATPase subunit interface; other site 311403011277 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 311403011278 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 311403011279 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 311403011280 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 311403011281 acyl-activating enzyme (AAE) consensus motif; other site 311403011282 putative AMP binding site [chemical binding]; other site 311403011283 putative active site [active] 311403011284 putative CoA binding site [chemical binding]; other site 311403011285 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 311403011286 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 311403011287 ATP binding site [chemical binding]; other site 311403011288 Mg++ binding site [ion binding]; other site 311403011289 motif III; other site 311403011290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403011291 nucleotide binding region [chemical binding]; other site 311403011292 ATP-binding site [chemical binding]; other site 311403011293 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 311403011294 RNA binding site [nucleotide binding]; other site 311403011295 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 311403011296 dimer interface [polypeptide binding]; other site 311403011297 PAS domain; Region: PAS_8; pfam13188 311403011298 PAS domain; Region: PAS_9; pfam13426 311403011299 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 311403011300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403011301 putative active site [active] 311403011302 heme pocket [chemical binding]; other site 311403011303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403011304 dimer interface [polypeptide binding]; other site 311403011305 phosphorylation site [posttranslational modification] 311403011306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403011307 ATP binding site [chemical binding]; other site 311403011308 Mg2+ binding site [ion binding]; other site 311403011309 G-X-G motif; other site 311403011310 Phasin protein; Region: Phasin_2; cl11491 311403011311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403011312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403011314 dimerization interface [polypeptide binding]; other site 311403011315 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 311403011316 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 311403011317 tetrameric interface [polypeptide binding]; other site 311403011318 NAD binding site [chemical binding]; other site 311403011319 catalytic residues [active] 311403011320 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 311403011321 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 311403011322 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 311403011323 iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920 311403011324 Rrf2 family protein; Region: rrf2_super; TIGR00738 311403011325 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403011326 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 311403011327 peptide binding site [polypeptide binding]; other site 311403011328 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403011329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403011330 dimer interface [polypeptide binding]; other site 311403011331 conserved gate region; other site 311403011332 putative PBP binding loops; other site 311403011333 ABC-ATPase subunit interface; other site 311403011334 dipeptide transporter; Provisional; Region: PRK10913 311403011335 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 311403011336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403011337 dimer interface [polypeptide binding]; other site 311403011338 conserved gate region; other site 311403011339 putative PBP binding loops; other site 311403011340 ABC-ATPase subunit interface; other site 311403011341 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403011342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403011343 Walker A/P-loop; other site 311403011344 ATP binding site [chemical binding]; other site 311403011345 Q-loop/lid; other site 311403011346 ABC transporter signature motif; other site 311403011347 Walker B; other site 311403011348 D-loop; other site 311403011349 H-loop/switch region; other site 311403011350 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403011351 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 311403011352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403011353 Walker A/P-loop; other site 311403011354 ATP binding site [chemical binding]; other site 311403011355 Q-loop/lid; other site 311403011356 ABC transporter signature motif; other site 311403011357 Walker B; other site 311403011358 D-loop; other site 311403011359 H-loop/switch region; other site 311403011360 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403011361 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 311403011362 AAA domain; Region: AAA_33; pfam13671 311403011363 ATP-binding site [chemical binding]; other site 311403011364 Gluconate-6-phosphate binding site [chemical binding]; other site 311403011365 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403011366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403011367 Phospholipid methyltransferase; Region: PEMT; cl17370 311403011368 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 311403011369 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 311403011370 malonyl-CoA binding site [chemical binding]; other site 311403011371 dimer interface [polypeptide binding]; other site 311403011372 active site 311403011373 product binding site; other site 311403011374 Tetratricopeptide repeat; Region: TPR_16; pfam13432 311403011375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403011376 binding surface 311403011377 TPR motif; other site 311403011378 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 311403011379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403011380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403011381 DNA binding residues [nucleotide binding] 311403011382 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 311403011383 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 311403011384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403011385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011386 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 311403011387 putative effector binding pocket; other site 311403011388 putative dimerization interface [polypeptide binding]; other site 311403011389 exopolyphosphatase; Region: exo_poly_only; TIGR03706 311403011390 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403011391 nucleotide binding site [chemical binding]; other site 311403011392 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 311403011393 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 311403011394 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 311403011395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403011396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403011397 putative substrate translocation pore; other site 311403011398 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 311403011399 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 311403011400 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 311403011401 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 311403011402 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 311403011403 active site 311403011404 MAPEG family; Region: MAPEG; cl09190 311403011405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403011406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403011407 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 311403011408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403011410 dimerization interface [polypeptide binding]; other site 311403011411 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 311403011412 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 311403011413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403011414 Walker A/P-loop; other site 311403011415 ATP binding site [chemical binding]; other site 311403011416 Q-loop/lid; other site 311403011417 ABC transporter signature motif; other site 311403011418 Walker B; other site 311403011419 D-loop; other site 311403011420 H-loop/switch region; other site 311403011421 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403011422 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 311403011423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 311403011424 Uncharacterized conserved protein [Function unknown]; Region: COG5403 311403011425 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 311403011426 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403011427 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 311403011428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 311403011429 RNA methyltransferase, RsmE family; Region: TIGR00046 311403011430 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 311403011431 Phosphate transporter family; Region: PHO4; pfam01384 311403011432 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 311403011433 nudix motif; other site 311403011434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011435 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403011436 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403011437 dimerization interface [polypeptide binding]; other site 311403011438 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 311403011439 NAD binding site [chemical binding]; other site 311403011440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011441 transcriptional activator TtdR; Provisional; Region: PRK09801 311403011442 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403011443 putative effector binding pocket; other site 311403011444 dimerization interface [polypeptide binding]; other site 311403011445 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 311403011446 FAD binding domain; Region: FAD_binding_4; pfam01565 311403011447 FAD binding domain; Region: FAD_binding_4; pfam01565 311403011448 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 311403011449 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 311403011450 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 311403011451 Cysteine-rich domain; Region: CCG; pfam02754 311403011452 Cysteine-rich domain; Region: CCG; pfam02754 311403011453 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 311403011454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403011455 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403011456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403011457 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403011458 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 311403011459 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 311403011460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 311403011461 motif II; other site 311403011462 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403011463 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403011464 active site 311403011465 catalytic tetrad [active] 311403011466 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 311403011467 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403011468 putative NAD(P) binding site [chemical binding]; other site 311403011469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403011470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011471 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 311403011472 putative effector binding pocket; other site 311403011473 putative dimerization interface [polypeptide binding]; other site 311403011474 YCII-related domain; Region: YCII; cl00999 311403011475 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403011476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403011477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403011478 dimerization interface [polypeptide binding]; other site 311403011479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 311403011480 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 311403011481 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 311403011482 dimer interface [polypeptide binding]; other site 311403011483 motif 1; other site 311403011484 active site 311403011485 motif 2; other site 311403011486 motif 3; other site 311403011487 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 311403011488 anticodon binding site; other site 311403011489 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 311403011490 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 311403011491 dimer interface [polypeptide binding]; other site 311403011492 motif 1; other site 311403011493 active site 311403011494 motif 2; other site 311403011495 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 311403011496 motif 3; other site 311403011497 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 311403011498 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 311403011499 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 311403011500 putative active site [active] 311403011501 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 311403011502 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 311403011503 Predicted membrane protein [Function unknown]; Region: COG2259 311403011504 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 311403011505 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 311403011506 C-terminal domain interface [polypeptide binding]; other site 311403011507 GSH binding site (G-site) [chemical binding]; other site 311403011508 dimer interface [polypeptide binding]; other site 311403011509 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 311403011510 N-terminal domain interface [polypeptide binding]; other site 311403011511 dimer interface [polypeptide binding]; other site 311403011512 substrate binding pocket (H-site) [chemical binding]; other site 311403011513 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 311403011514 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 311403011515 ring oligomerisation interface [polypeptide binding]; other site 311403011516 ATP/Mg binding site [chemical binding]; other site 311403011517 stacking interactions; other site 311403011518 hinge regions; other site 311403011519 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 311403011520 oligomerisation interface [polypeptide binding]; other site 311403011521 mobile loop; other site 311403011522 roof hairpin; other site 311403011523 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 311403011524 Chromate transporter; Region: Chromate_transp; pfam02417 311403011525 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 311403011526 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 311403011527 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 311403011528 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 311403011529 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 311403011530 active site 311403011531 Riboflavin kinase; Region: Flavokinase; smart00904 311403011532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 311403011533 Cache domain; Region: Cache_2; pfam08269 311403011534 Histidine kinase; Region: HisKA_3; pfam07730 311403011535 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403011536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403011537 active site 311403011538 phosphorylation site [posttranslational modification] 311403011539 intermolecular recognition site; other site 311403011540 dimerization interface [polypeptide binding]; other site 311403011541 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403011542 DNA binding residues [nucleotide binding] 311403011543 dimerization interface [polypeptide binding]; other site 311403011544 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 311403011545 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 311403011546 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 311403011547 Na binding site [ion binding]; other site 311403011548 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 311403011549 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 311403011550 active site 311403011551 HIGH motif; other site 311403011552 nucleotide binding site [chemical binding]; other site 311403011553 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 311403011554 active site 311403011555 KMSKS motif; other site 311403011556 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 311403011557 tRNA binding surface [nucleotide binding]; other site 311403011558 anticodon binding site; other site 311403011559 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 311403011560 nucleoside/Zn binding site; other site 311403011561 dimer interface [polypeptide binding]; other site 311403011562 catalytic motif [active] 311403011563 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 311403011564 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403011565 RNA binding surface [nucleotide binding]; other site 311403011566 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 311403011567 active site 311403011568 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 311403011569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403011570 S-adenosylmethionine binding site [chemical binding]; other site 311403011571 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 311403011572 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 311403011573 active site 311403011574 nucleophile elbow; other site 311403011575 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 311403011576 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 311403011577 TrkA-N domain; Region: TrkA_N; pfam02254 311403011578 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 311403011579 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403011580 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 311403011581 active site 311403011582 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 311403011583 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 311403011584 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 311403011585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403011586 motif II; other site 311403011587 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 311403011588 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 311403011589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 311403011590 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 311403011591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403011592 ATP binding site [chemical binding]; other site 311403011593 Mg2+ binding site [ion binding]; other site 311403011594 G-X-G motif; other site 311403011595 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 311403011596 ATP binding site [chemical binding]; other site 311403011597 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 311403011598 PAS fold; Region: PAS_7; pfam12860 311403011599 PAS domain; Region: PAS; smart00091 311403011600 PAS fold; Region: PAS_4; pfam08448 311403011601 putative active site [active] 311403011602 heme pocket [chemical binding]; other site 311403011603 Response regulator receiver domain; Region: Response_reg; pfam00072 311403011604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403011605 active site 311403011606 phosphorylation site [posttranslational modification] 311403011607 intermolecular recognition site; other site 311403011608 dimerization interface [polypeptide binding]; other site 311403011609 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403011610 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403011611 metal binding site [ion binding]; metal-binding site 311403011612 active site 311403011613 I-site; other site 311403011614 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403011615 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403011616 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403011617 dimerization interface [polypeptide binding]; other site 311403011618 putative DNA binding site [nucleotide binding]; other site 311403011619 putative Zn2+ binding site [ion binding]; other site 311403011620 AsnC family; Region: AsnC_trans_reg; pfam01037 311403011621 argininosuccinate synthase; Provisional; Region: PRK13820 311403011622 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 311403011623 ANP binding site [chemical binding]; other site 311403011624 Substrate Binding Site II [chemical binding]; other site 311403011625 Substrate Binding Site I [chemical binding]; other site 311403011626 PRC-barrel domain; Region: PRC; pfam05239 311403011627 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 311403011628 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 311403011629 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 311403011630 active site 311403011631 intersubunit interface [polypeptide binding]; other site 311403011632 catalytic residue [active] 311403011633 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 311403011634 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 311403011635 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403011636 classical (c) SDRs; Region: SDR_c; cd05233 311403011637 NAD(P) binding site [chemical binding]; other site 311403011638 active site 311403011639 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403011640 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 311403011641 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403011642 Autoinducer binding domain; Region: Autoind_bind; pfam03472 311403011643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403011644 DNA binding residues [nucleotide binding] 311403011645 dimerization interface [polypeptide binding]; other site 311403011646 antiporter inner membrane protein; Provisional; Region: PRK11670 311403011647 Domain of unknown function DUF59; Region: DUF59; pfam01883 311403011648 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 311403011649 Walker A motif; other site 311403011650 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 311403011651 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 311403011652 oligomer interface [polypeptide binding]; other site 311403011653 Cl binding site [ion binding]; other site 311403011654 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 311403011655 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 311403011656 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 311403011657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 311403011658 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 311403011659 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 311403011660 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 311403011661 F0F1 ATP synthase subunit B'; Validated; Region: PRK09174 311403011662 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 311403011663 F0F1 ATP synthase subunit B; Validated; Region: PRK09173 311403011664 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 311403011665 Phosphotransferase enzyme family; Region: APH; pfam01636 311403011666 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 311403011667 active site 311403011668 ATP binding site [chemical binding]; other site 311403011669 substrate binding site [chemical binding]; other site 311403011670 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 311403011671 RNA/DNA hybrid binding site [nucleotide binding]; other site 311403011672 active site 311403011673 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 311403011674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403011675 FeS/SAM binding site; other site 311403011676 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 311403011677 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 311403011678 MPT binding site; other site 311403011679 trimer interface [polypeptide binding]; other site 311403011680 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 311403011681 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 311403011682 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 311403011683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 311403011684 TPR motif; other site 311403011685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 311403011686 TPR motif; other site 311403011687 binding surface 311403011688 TPR repeat; Region: TPR_11; pfam13414 311403011689 TPR repeat; Region: TPR_11; pfam13414 311403011690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403011691 binding surface 311403011692 TPR motif; other site 311403011693 TPR repeat; Region: TPR_11; pfam13414 311403011694 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 311403011695 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 311403011696 substrate binding pocket [chemical binding]; other site 311403011697 chain length determination region; other site 311403011698 substrate-Mg2+ binding site; other site 311403011699 catalytic residues [active] 311403011700 aspartate-rich region 1; other site 311403011701 active site lid residues [active] 311403011702 aspartate-rich region 2; other site 311403011703 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 311403011704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403011705 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403011706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403011707 non-specific DNA binding site [nucleotide binding]; other site 311403011708 salt bridge; other site 311403011709 sequence-specific DNA binding site [nucleotide binding]; other site 311403011710 Cupin domain; Region: Cupin_2; pfam07883 311403011711 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 311403011712 AAA domain; Region: AAA_33; pfam13671 311403011713 active site 311403011714 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 311403011715 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 311403011716 tandem repeat interface [polypeptide binding]; other site 311403011717 oligomer interface [polypeptide binding]; other site 311403011718 active site residues [active] 311403011719 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 311403011720 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 311403011721 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 311403011722 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 311403011723 dimer interface [polypeptide binding]; other site 311403011724 motif 1; other site 311403011725 active site 311403011726 motif 2; other site 311403011727 motif 3; other site 311403011728 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 311403011729 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 311403011730 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 311403011731 hinge; other site 311403011732 active site 311403011733 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 311403011734 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 311403011735 putative active site [active] 311403011736 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 311403011737 Uncharacterized conserved protein [Function unknown]; Region: COG1683 311403011738 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 311403011739 HAMP domain; Region: HAMP; pfam00672 311403011740 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403011741 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403011742 dimer interface [polypeptide binding]; other site 311403011743 putative CheW interface [polypeptide binding]; other site 311403011744 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 311403011745 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 311403011746 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 311403011747 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 311403011748 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 311403011749 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 311403011750 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 311403011751 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 311403011752 RNA binding site [nucleotide binding]; other site 311403011753 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 311403011754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403011755 S-adenosylmethionine binding site [chemical binding]; other site 311403011756 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 311403011757 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 311403011758 UbiA prenyltransferase family; Region: UbiA; pfam01040 311403011759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403011760 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 311403011761 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 311403011762 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 311403011763 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 311403011764 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 311403011765 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 311403011766 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 311403011767 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 311403011768 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 311403011769 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 311403011770 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 311403011771 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 311403011772 FAD binding domain; Region: FAD_binding_4; pfam01565 311403011773 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 311403011774 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 311403011775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 311403011776 ACT domain; Region: ACT_3; pfam10000 311403011777 Family description; Region: ACT_7; pfam13840 311403011778 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 311403011779 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 311403011780 [2Fe-2S] cluster binding site [ion binding]; other site 311403011781 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 311403011782 putative alpha subunit interface [polypeptide binding]; other site 311403011783 putative active site [active] 311403011784 putative substrate binding site [chemical binding]; other site 311403011785 Fe binding site [ion binding]; other site 311403011786 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 311403011787 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 311403011788 FAD binding pocket [chemical binding]; other site 311403011789 FAD binding motif [chemical binding]; other site 311403011790 phosphate binding motif [ion binding]; other site 311403011791 beta-alpha-beta structure motif; other site 311403011792 NAD binding pocket [chemical binding]; other site 311403011793 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403011794 catalytic loop [active] 311403011795 iron binding site [ion binding]; other site 311403011796 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 311403011797 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 311403011798 active site 311403011799 BA14K-like protein; Region: BA14K; pfam07886 311403011800 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 311403011801 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 311403011802 Cl binding site [ion binding]; other site 311403011803 oligomer interface [polypeptide binding]; other site 311403011804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403011805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403011806 active site 311403011807 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 311403011808 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403011809 enoyl-CoA hydratase; Provisional; Region: PRK06688 311403011810 substrate binding site [chemical binding]; other site 311403011811 oxyanion hole (OAH) forming residues; other site 311403011812 trimer interface [polypeptide binding]; other site 311403011813 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 311403011814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403011815 S-adenosylmethionine binding site [chemical binding]; other site 311403011816 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 311403011817 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403011818 RNA binding surface [nucleotide binding]; other site 311403011819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403011820 S-adenosylmethionine binding site [chemical binding]; other site 311403011821 CHASE3 domain; Region: CHASE3; cl05000 311403011822 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403011823 dimer interface [polypeptide binding]; other site 311403011824 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 311403011825 putative CheW interface [polypeptide binding]; other site 311403011826 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 311403011827 GAF domain; Region: GAF; pfam01590 311403011828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403011829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403011830 metal binding site [ion binding]; metal-binding site 311403011831 active site 311403011832 I-site; other site 311403011833 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 311403011834 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 311403011835 TPP-binding site; other site 311403011836 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 311403011837 PYR/PP interface [polypeptide binding]; other site 311403011838 dimer interface [polypeptide binding]; other site 311403011839 TPP binding site [chemical binding]; other site 311403011840 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 311403011841 Pirin-related protein [General function prediction only]; Region: COG1741 311403011842 Pirin; Region: Pirin; pfam02678 311403011843 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 311403011844 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 311403011845 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 311403011846 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 311403011847 putative active site [active] 311403011848 Zn binding site [ion binding]; other site 311403011849 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 311403011850 active site 311403011851 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 311403011852 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 311403011853 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 311403011854 Walker A/P-loop; other site 311403011855 ATP binding site [chemical binding]; other site 311403011856 Q-loop/lid; other site 311403011857 ABC transporter signature motif; other site 311403011858 Walker B; other site 311403011859 D-loop; other site 311403011860 H-loop/switch region; other site 311403011861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 311403011862 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 311403011863 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314 311403011864 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 311403011865 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 311403011866 dimerization interface [polypeptide binding]; other site 311403011867 active site 311403011868 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 311403011869 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 311403011870 Tetramer interface [polypeptide binding]; other site 311403011871 active site 311403011872 FMN-binding site [chemical binding]; other site 311403011873 Protein of unknown function (DUF1344); Region: DUF1344; pfam07076 311403011874 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403011875 catalytic core [active] 311403011876 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 311403011877 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 311403011878 NAD binding site [chemical binding]; other site 311403011879 homotetramer interface [polypeptide binding]; other site 311403011880 homodimer interface [polypeptide binding]; other site 311403011881 substrate binding site [chemical binding]; other site 311403011882 active site 311403011883 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 311403011884 chaperone protein DnaJ; Provisional; Region: PRK14288 311403011885 HSP70 interaction site [polypeptide binding]; other site 311403011886 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 311403011887 dimer interface [polypeptide binding]; other site 311403011888 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 311403011889 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 311403011890 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 311403011891 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 311403011892 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 311403011893 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 311403011894 putative active site [active] 311403011895 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 311403011896 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 311403011897 Sporulation related domain; Region: SPOR; pfam05036 311403011898 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 311403011899 metal binding site [ion binding]; metal-binding site 311403011900 protease TldD; Provisional; Region: tldD; PRK10735 311403011901 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 311403011902 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00051 311403011903 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 311403011904 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 311403011905 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 311403011906 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 311403011907 Subunit I/III interface [polypeptide binding]; other site 311403011908 D-pathway; other site 311403011909 Subunit I/VIIc interface [polypeptide binding]; other site 311403011910 Subunit I/IV interface [polypeptide binding]; other site 311403011911 Subunit I/II interface [polypeptide binding]; other site 311403011912 Low-spin heme (heme a) binding site [chemical binding]; other site 311403011913 Subunit I/VIIa interface [polypeptide binding]; other site 311403011914 Subunit I/VIa interface [polypeptide binding]; other site 311403011915 Dimer interface; other site 311403011916 Putative water exit pathway; other site 311403011917 Binuclear center (heme a3/CuB) [ion binding]; other site 311403011918 K-pathway; other site 311403011919 Subunit I/Vb interface [polypeptide binding]; other site 311403011920 Putative proton exit pathway; other site 311403011921 Subunit I/VIb interface; other site 311403011922 Subunit I/VIc interface [polypeptide binding]; other site 311403011923 Electron transfer pathway; other site 311403011924 Subunit I/VIIIb interface [polypeptide binding]; other site 311403011925 Subunit I/VIIb interface [polypeptide binding]; other site 311403011926 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 311403011927 UbiA prenyltransferase family; Region: UbiA; pfam01040 311403011928 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 311403011929 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 311403011930 Subunit III/VIIa interface [polypeptide binding]; other site 311403011931 Phospholipid binding site [chemical binding]; other site 311403011932 Subunit I/III interface [polypeptide binding]; other site 311403011933 Subunit III/VIb interface [polypeptide binding]; other site 311403011934 Subunit III/VIa interface; other site 311403011935 Subunit III/Vb interface [polypeptide binding]; other site 311403011936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 311403011937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403011938 putative DNA binding site [nucleotide binding]; other site 311403011939 dimerization interface [polypeptide binding]; other site 311403011940 putative Zn2+ binding site [ion binding]; other site 311403011941 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 311403011942 putative hydrophobic ligand binding site [chemical binding]; other site 311403011943 Uncharacterized conserved protein [Function unknown]; Region: COG3791 311403011944 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 311403011945 P-loop motif; other site 311403011946 ATP binding site [chemical binding]; other site 311403011947 Chloramphenicol (Cm) binding site [chemical binding]; other site 311403011948 catalytic residue [active] 311403011949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349 311403011950 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 311403011951 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 311403011952 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 311403011953 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 311403011954 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 311403011955 putative active site [active] 311403011956 putative substrate binding site [chemical binding]; other site 311403011957 ATP binding site [chemical binding]; other site 311403011958 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 311403011959 RNA/DNA hybrid binding site [nucleotide binding]; other site 311403011960 active site 311403011961 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 311403011962 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 311403011963 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 311403011964 metal binding site [ion binding]; metal-binding site 311403011965 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 311403011966 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403011967 ABC-ATPase subunit interface; other site 311403011968 dimer interface [polypeptide binding]; other site 311403011969 putative PBP binding regions; other site 311403011970 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 311403011971 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 311403011972 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 311403011973 catalytic triad [active] 311403011974 dimer interface [polypeptide binding]; other site 311403011975 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 311403011976 hypothetical protein; Validated; Region: PRK00228 311403011977 CsbD-like; Region: CsbD; cl17424 311403011978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 311403011979 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 311403011980 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 311403011981 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 311403011982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403011983 PAS fold; Region: PAS_3; pfam08447 311403011984 putative active site [active] 311403011985 heme pocket [chemical binding]; other site 311403011986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403011987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403011988 metal binding site [ion binding]; metal-binding site 311403011989 active site 311403011990 I-site; other site 311403011991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403011992 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 311403011993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403011994 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 311403011995 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 311403011996 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 311403011997 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 311403011998 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 311403011999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403012000 catalytic residue [active] 311403012001 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 311403012002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403012003 motif II; other site 311403012004 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 311403012005 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403012006 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403012007 DNA-binding site [nucleotide binding]; DNA binding site 311403012008 FCD domain; Region: FCD; pfam07729 311403012009 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 311403012010 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 311403012011 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 311403012012 Beta-lactamase; Region: Beta-lactamase; pfam00144 311403012013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403012014 dimerization interface [polypeptide binding]; other site 311403012015 putative DNA binding site [nucleotide binding]; other site 311403012016 putative Zn2+ binding site [ion binding]; other site 311403012017 NIPSNAP; Region: NIPSNAP; pfam07978 311403012018 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 311403012019 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 311403012020 DNA methylase; Region: N6_N4_Mtase; pfam01555 311403012021 SnoaL-like domain; Region: SnoaL_2; pfam12680 311403012022 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 311403012023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403012024 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 311403012025 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 311403012026 minor groove reading motif; other site 311403012027 helix-hairpin-helix signature motif; other site 311403012028 substrate binding pocket [chemical binding]; other site 311403012029 active site 311403012030 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 311403012031 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 311403012032 DNA binding and oxoG recognition site [nucleotide binding] 311403012033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389 311403012034 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 311403012035 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 311403012036 catalytic residues [active] 311403012037 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 311403012038 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 311403012039 Walker A/P-loop; other site 311403012040 ATP binding site [chemical binding]; other site 311403012041 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 311403012042 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 311403012043 ABC transporter signature motif; other site 311403012044 Walker B; other site 311403012045 D-loop; other site 311403012046 H-loop/switch region; other site 311403012047 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 311403012048 Domain of unknown function DUF21; Region: DUF21; pfam01595 311403012049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 311403012050 Transporter associated domain; Region: CorC_HlyC; smart01091 311403012051 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 311403012052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403012053 salt bridge; other site 311403012054 non-specific DNA binding site [nucleotide binding]; other site 311403012055 sequence-specific DNA binding site [nucleotide binding]; other site 311403012056 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 311403012057 pyruvate phosphate dikinase; Provisional; Region: PRK09279 311403012058 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 311403012059 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 311403012060 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 311403012061 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 311403012062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 311403012063 Cupin domain; Region: Cupin_2; cl17218 311403012064 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 311403012065 DNA binding site [nucleotide binding] 311403012066 active site 311403012067 Int/Topo IB signature motif; other site 311403012068 catalytic residues [active] 311403012069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403012070 non-specific DNA binding site [nucleotide binding]; other site 311403012071 salt bridge; other site 311403012072 sequence-specific DNA binding site [nucleotide binding]; other site 311403012073 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 311403012074 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 311403012075 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 311403012076 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 311403012077 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 311403012078 GAF domain; Region: GAF_2; pfam13185 311403012079 methionine sulfoxide reductase B; Provisional; Region: PRK00222 311403012080 SelR domain; Region: SelR; pfam01641 311403012081 methionine sulfoxide reductase A; Provisional; Region: PRK14054 311403012082 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403012083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403012084 The C-terminal substrate binding domain of LysR-type transcriptional regulator TrpI, which is involved in control of tryptophan synthesis, contains type 2 periplasmic binding fold; Region: PBP2_TrpI; cd08482 311403012085 putative dimerization interface [polypeptide binding]; other site 311403012086 putative substrate binding pocket [chemical binding]; other site 311403012087 Methyltransferase domain; Region: Methyltransf_11; pfam08241 311403012088 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 311403012089 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 311403012090 Porin subfamily; Region: Porin_2; pfam02530 311403012091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403012092 putative substrate translocation pore; other site 311403012093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403012094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403012095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403012096 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 311403012097 putative effector binding pocket; other site 311403012098 putative dimerization interface [polypeptide binding]; other site 311403012099 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 311403012100 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 311403012101 CysD dimerization site [polypeptide binding]; other site 311403012102 G1 box; other site 311403012103 putative GEF interaction site [polypeptide binding]; other site 311403012104 GTP/Mg2+ binding site [chemical binding]; other site 311403012105 Switch I region; other site 311403012106 G2 box; other site 311403012107 G3 box; other site 311403012108 Switch II region; other site 311403012109 G4 box; other site 311403012110 G5 box; other site 311403012111 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 311403012112 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 311403012113 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 311403012114 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 311403012115 Active Sites [active] 311403012116 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 311403012117 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 311403012118 Active Sites [active] 311403012119 Rrf2 family protein; Region: rrf2_super; TIGR00738 311403012120 Transcriptional regulator; Region: Rrf2; pfam02082 311403012121 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 311403012122 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 311403012123 putative ion selectivity filter; other site 311403012124 putative pore gating glutamate residue; other site 311403012125 putative H+/Cl- coupling transport residue; other site 311403012126 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 311403012127 choline dehydrogenase; Validated; Region: PRK02106 311403012128 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403012129 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 311403012130 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 311403012131 NAD(P) binding site [chemical binding]; other site 311403012132 catalytic residues [active] 311403012133 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403012134 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 311403012135 putative C-terminal domain interface [polypeptide binding]; other site 311403012136 putative GSH binding site (G-site) [chemical binding]; other site 311403012137 putative dimer interface [polypeptide binding]; other site 311403012138 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 311403012139 N-terminal domain interface [polypeptide binding]; other site 311403012140 dimer interface [polypeptide binding]; other site 311403012141 substrate binding pocket (H-site) [chemical binding]; other site 311403012142 transcriptional regulator BetI; Validated; Region: PRK00767 311403012143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403012144 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 311403012145 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 311403012146 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 311403012147 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403012148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 311403012149 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403012150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403012151 metal binding site [ion binding]; metal-binding site 311403012152 active site 311403012153 I-site; other site 311403012154 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 311403012155 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 311403012156 NAD(P) binding site [chemical binding]; other site 311403012157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403012158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403012159 putative substrate translocation pore; other site 311403012160 Predicted transcriptional regulator [Transcription]; Region: COG2345 311403012161 L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448 311403012162 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403012163 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403012164 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403012165 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 311403012166 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 311403012167 glutathionine S-transferase; Provisional; Region: PRK10542 311403012168 C-terminal domain interface [polypeptide binding]; other site 311403012169 GSH binding site (G-site) [chemical binding]; other site 311403012170 dimer interface [polypeptide binding]; other site 311403012171 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 311403012172 dimer interface [polypeptide binding]; other site 311403012173 N-terminal domain interface [polypeptide binding]; other site 311403012174 substrate binding pocket (H-site) [chemical binding]; other site 311403012175 Protein of unknown function (DUF419); Region: DUF419; cl15265 311403012176 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403012177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403012178 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403012179 dimerization interface [polypeptide binding]; other site 311403012180 substrate binding pocket [chemical binding]; other site 311403012181 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403012182 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 311403012183 putative C-terminal domain interface [polypeptide binding]; other site 311403012184 putative GSH binding site (G-site) [chemical binding]; other site 311403012185 putative dimer interface [polypeptide binding]; other site 311403012186 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 311403012187 dimer interface [polypeptide binding]; other site 311403012188 N-terminal domain interface [polypeptide binding]; other site 311403012189 putative substrate binding pocket (H-site) [chemical binding]; other site 311403012190 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 311403012191 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 311403012192 dimer interface [polypeptide binding]; other site 311403012193 PYR/PP interface [polypeptide binding]; other site 311403012194 TPP binding site [chemical binding]; other site 311403012195 substrate binding site [chemical binding]; other site 311403012196 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 311403012197 TPP-binding site [chemical binding]; other site 311403012198 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 311403012199 isovaleryl-CoA dehydrogenase; Region: PLN02519 311403012200 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 311403012201 substrate binding site [chemical binding]; other site 311403012202 FAD binding site [chemical binding]; other site 311403012203 catalytic base [active] 311403012204 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 311403012205 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 311403012206 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 311403012207 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 311403012208 homotrimer interaction site [polypeptide binding]; other site 311403012209 putative active site [active] 311403012210 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 311403012211 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403012212 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403012213 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 311403012214 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403012215 carboxyltransferase (CT) interaction site; other site 311403012216 biotinylation site [posttranslational modification]; other site 311403012217 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 311403012218 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 311403012219 active site 311403012220 catalytic residues [active] 311403012221 metal binding site [ion binding]; metal-binding site 311403012222 enoyl-CoA hydratase; Provisional; Region: PRK07468 311403012223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403012224 substrate binding site [chemical binding]; other site 311403012225 oxyanion hole (OAH) forming residues; other site 311403012226 trimer interface [polypeptide binding]; other site 311403012227 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 311403012228 Predicted amidohydrolase [General function prediction only]; Region: COG0388 311403012229 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 311403012230 active site 311403012231 catalytic triad [active] 311403012232 dimer interface [polypeptide binding]; other site 311403012233 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 311403012234 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 311403012235 ATP-dependent DNA ligase; Validated; Region: PRK09247 311403012236 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 311403012237 active site 311403012238 DNA binding site [nucleotide binding] 311403012239 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 311403012240 DNA binding site [nucleotide binding] 311403012241 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 311403012242 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403012243 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 311403012244 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 311403012245 active site 311403012246 substrate binding site [chemical binding]; other site 311403012247 coenzyme B12 binding site [chemical binding]; other site 311403012248 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 311403012249 B12 binding site [chemical binding]; other site 311403012250 cobalt ligand [ion binding]; other site 311403012251 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 311403012252 heterodimer interface [polypeptide binding]; other site 311403012253 substrate interaction site [chemical binding]; other site 311403012254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403012255 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403012256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403012257 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403012258 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403012259 MarR family; Region: MarR; pfam01047 311403012260 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 311403012261 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 311403012262 RES domain; Region: RES; smart00953 311403012263 MarR family; Region: MarR_2; cl17246 311403012264 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403012265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 311403012266 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 311403012267 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403012268 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 311403012269 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403012270 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 311403012271 Domain of unknown function DUF87; Region: DUF87; pfam01935 311403012272 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 311403012273 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403012274 active site 311403012275 metal binding site [ion binding]; metal-binding site 311403012276 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 311403012277 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 311403012278 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 311403012279 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 311403012280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403012281 S-adenosylmethionine binding site [chemical binding]; other site 311403012282 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 311403012283 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 311403012284 putative NAD(P) binding site [chemical binding]; other site 311403012285 catalytic Zn binding site [ion binding]; other site 311403012286 structural Zn binding site [ion binding]; other site 311403012287 aminotransferase; Provisional; Region: PRK13356 311403012288 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 311403012289 homodimer interface [polypeptide binding]; other site 311403012290 substrate-cofactor binding pocket; other site 311403012291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403012292 catalytic residue [active] 311403012293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403012294 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403012295 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 311403012296 drug efflux system protein MdtG; Provisional; Region: PRK09874 311403012297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403012298 putative substrate translocation pore; other site 311403012299 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 311403012300 substrate binding site [chemical binding]; other site 311403012301 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403012302 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 311403012303 BON domain; Region: BON; pfam04972 311403012304 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403012305 DNA-binding site [nucleotide binding]; DNA binding site 311403012306 RNA-binding motif; other site 311403012307 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 311403012308 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 311403012309 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 311403012310 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 311403012311 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403012312 active site 311403012313 metal binding site [ion binding]; metal-binding site 311403012314 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 311403012315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403012316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403012317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403012318 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403012319 NAD(P) binding site [chemical binding]; other site 311403012320 active site 311403012321 Predicted transcriptional regulator [Transcription]; Region: COG2378 311403012322 HTH domain; Region: HTH_11; pfam08279 311403012323 WYL domain; Region: WYL; pfam13280 311403012324 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403012325 Cytochrome C' Region: Cytochrom_C_2; cl01610 311403012326 Cytochrome c; Region: Cytochrom_C; pfam00034 311403012327 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 311403012328 Cytochrome c; Region: Cytochrom_C; pfam00034 311403012329 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403012330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403012331 S-adenosylmethionine binding site [chemical binding]; other site 311403012332 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 311403012333 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403012334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403012335 Coenzyme A binding pocket [chemical binding]; other site 311403012336 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 311403012337 putative metal binding site [ion binding]; other site 311403012338 putative homodimer interface [polypeptide binding]; other site 311403012339 putative homotetramer interface [polypeptide binding]; other site 311403012340 putative homodimer-homodimer interface [polypeptide binding]; other site 311403012341 putative allosteric switch controlling residues; other site 311403012342 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 311403012343 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 311403012344 Uncharacterized conserved protein [Function unknown]; Region: COG0397 311403012345 hypothetical protein; Validated; Region: PRK00029 311403012346 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 311403012347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403012348 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403012349 active site 311403012350 metal binding site [ion binding]; metal-binding site 311403012351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 311403012352 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 311403012353 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403012354 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 311403012355 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 311403012356 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 311403012357 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 311403012358 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 311403012359 HSP70 interaction site [polypeptide binding]; other site 311403012360 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 311403012361 substrate binding site [polypeptide binding]; other site 311403012362 dimer interface [polypeptide binding]; other site 311403012363 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 311403012364 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 311403012365 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 311403012366 Domain of unknown function DUF20; Region: UPF0118; pfam01594 311403012367 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 311403012368 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 311403012369 putative metal binding site [ion binding]; other site 311403012370 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 311403012371 active site 311403012372 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 311403012373 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 311403012374 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 311403012375 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403012376 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 311403012377 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 311403012378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 311403012379 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 311403012380 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 311403012381 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658 311403012382 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 311403012383 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 311403012384 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 311403012385 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 311403012386 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 311403012387 Predicted transcriptional regulator [Transcription]; Region: COG4957 311403012388 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 311403012389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403012390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403012391 dimer interface [polypeptide binding]; other site 311403012392 phosphorylation site [posttranslational modification] 311403012393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403012394 ATP binding site [chemical binding]; other site 311403012395 Mg2+ binding site [ion binding]; other site 311403012396 G-X-G motif; other site 311403012397 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403012398 Uncharacterized conserved protein [Function unknown]; Region: COG5447 311403012399 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 311403012400 Predicted integral membrane protein [Function unknown]; Region: COG5436 311403012401 Uncharacterized conserved protein [Function unknown]; Region: COG5402 311403012402 Transglycosylase; Region: Transgly; pfam00912 311403012403 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 311403012404 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 311403012405 hypothetical protein; Provisional; Region: PRK05170 311403012406 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 311403012407 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403012408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403012409 active site 311403012410 phosphorylation site [posttranslational modification] 311403012411 intermolecular recognition site; other site 311403012412 dimerization interface [polypeptide binding]; other site 311403012413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403012414 DNA binding site [nucleotide binding] 311403012415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403012416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403012417 ATP binding site [chemical binding]; other site 311403012418 Mg2+ binding site [ion binding]; other site 311403012419 G-X-G motif; other site 311403012420 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 311403012421 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 311403012422 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 311403012423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 311403012424 binding surface 311403012425 TPR motif; other site 311403012426 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 311403012427 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 311403012428 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 311403012429 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 311403012430 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403012431 protein binding site [polypeptide binding]; other site 311403012432 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403012433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403012434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403012435 active site 311403012436 phosphorylation site [posttranslational modification] 311403012437 intermolecular recognition site; other site 311403012438 dimerization interface [polypeptide binding]; other site 311403012439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403012440 DNA binding site [nucleotide binding] 311403012441 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 311403012442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403012443 dimerization interface [polypeptide binding]; other site 311403012444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403012445 dimer interface [polypeptide binding]; other site 311403012446 phosphorylation site [posttranslational modification] 311403012447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403012448 ATP binding site [chemical binding]; other site 311403012449 Mg2+ binding site [ion binding]; other site 311403012450 G-X-G motif; other site 311403012451 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 311403012452 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 311403012453 metal binding triad; other site 311403012454 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 311403012455 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 311403012456 metal binding triad; other site 311403012457 PAS fold; Region: PAS_3; pfam08447 311403012458 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 311403012459 PAS fold; Region: PAS_7; pfam12860 311403012460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403012461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403012462 dimer interface [polypeptide binding]; other site 311403012463 phosphorylation site [posttranslational modification] 311403012464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403012465 ATP binding site [chemical binding]; other site 311403012466 Mg2+ binding site [ion binding]; other site 311403012467 G-X-G motif; other site 311403012468 aminopeptidase N; Provisional; Region: pepN; PRK14015 311403012469 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 311403012470 active site 311403012471 Zn binding site [ion binding]; other site 311403012472 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403012473 putative CheW interface [polypeptide binding]; other site 311403012474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403012475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403012476 putative substrate translocation pore; other site 311403012477 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 311403012478 Fe-S cluster binding site [ion binding]; other site 311403012479 active site 311403012480 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 311403012481 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 311403012482 nucleotide binding site [chemical binding]; other site 311403012483 putative NEF/HSP70 interaction site [polypeptide binding]; other site 311403012484 SBD interface [polypeptide binding]; other site 311403012485 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403012486 Protein export membrane protein; Region: SecD_SecF; cl14618 311403012487 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403012488 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403012489 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403012490 short chain dehydrogenase; Provisional; Region: PRK08339 311403012491 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 311403012492 putative NAD(P) binding site [chemical binding]; other site 311403012493 putative active site [active] 311403012494 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 311403012495 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403012496 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 311403012497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403012498 Coenzyme A binding pocket [chemical binding]; other site 311403012499 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403012500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403012501 putative DNA binding site [nucleotide binding]; other site 311403012502 putative Zn2+ binding site [ion binding]; other site 311403012503 AsnC family; Region: AsnC_trans_reg; pfam01037 311403012504 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 311403012505 MgtE intracellular N domain; Region: MgtE_N; pfam03448 311403012506 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 311403012507 Divalent cation transporter; Region: MgtE; pfam01769 311403012508 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 311403012509 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 311403012510 putative NAD(P) binding site [chemical binding]; other site 311403012511 dimer interface [polypeptide binding]; other site 311403012512 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403012513 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403012514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403012515 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 311403012516 putative substrate translocation pore; other site 311403012517 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 311403012518 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 311403012519 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 311403012520 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 311403012521 putative aminotransferase; Validated; Region: PRK07480 311403012522 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403012523 inhibitor-cofactor binding pocket; inhibition site 311403012524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403012525 catalytic residue [active] 311403012526 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 311403012527 dimer interface [polypeptide binding]; other site 311403012528 ADP-ribose binding site [chemical binding]; other site 311403012529 active site 311403012530 nudix motif; other site 311403012531 metal binding site [ion binding]; metal-binding site 311403012532 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 311403012533 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 311403012534 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 311403012535 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 311403012536 Ligand binding site; other site 311403012537 Putative Catalytic site; other site 311403012538 DXD motif; other site 311403012539 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 311403012540 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 311403012541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403012542 DNA binding residues [nucleotide binding] 311403012543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 311403012544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 311403012545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 311403012546 AMP nucleosidase; Provisional; Region: PRK08292 311403012547 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 311403012548 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 311403012549 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 311403012550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403012551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731 311403012552 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403012553 Sel1 repeat; Region: Sel1; cl02723 311403012554 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 311403012555 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403012556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403012557 homodimer interface [polypeptide binding]; other site 311403012558 catalytic residue [active] 311403012559 Protein required for attachment to host cells; Region: Host_attach; pfam10116 311403012560 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 311403012561 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 311403012562 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 311403012563 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 311403012564 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403012565 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 311403012566 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 311403012567 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403012568 dimer interface [polypeptide binding]; other site 311403012569 PYR/PP interface [polypeptide binding]; other site 311403012570 TPP binding site [chemical binding]; other site 311403012571 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 311403012572 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 311403012573 TPP-binding site; other site 311403012574 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403012575 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 311403012576 substrate binding site [chemical binding]; other site 311403012577 ATP binding site [chemical binding]; other site 311403012578 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 311403012579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 311403012580 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403012581 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403012582 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403012583 putative active site [active] 311403012584 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403012585 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403012586 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403012587 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 311403012588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403012589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403012590 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403012591 DNA-binding site [nucleotide binding]; DNA binding site 311403012592 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 311403012593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403012594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403012595 homodimer interface [polypeptide binding]; other site 311403012596 catalytic residue [active] 311403012597 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 311403012598 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 311403012599 Sodium Bile acid symporter family; Region: SBF; cl17470 311403012600 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 311403012601 ArsC family; Region: ArsC; pfam03960 311403012602 catalytic residues [active] 311403012603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403012604 dimerization interface [polypeptide binding]; other site 311403012605 putative DNA binding site [nucleotide binding]; other site 311403012606 putative Zn2+ binding site [ion binding]; other site 311403012607 Porin subfamily; Region: Porin_2; pfam02530 311403012608 Porin subfamily; Region: Porin_2; pfam02530 311403012609 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403012610 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 311403012611 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 311403012612 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403012613 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403012614 catalytic residue [active] 311403012615 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403012616 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 311403012617 dimer interface [polypeptide binding]; other site 311403012618 active site 311403012619 catalytic residue [active] 311403012620 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 311403012621 SmpB-tmRNA interface; other site 311403012622 Uncharacterized conserved protein [Function unknown]; Region: COG1432 311403012623 LabA_like proteins; Region: LabA; cd10911 311403012624 putative metal binding site [ion binding]; other site 311403012625 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 311403012626 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 311403012627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 311403012628 Zn2+ binding site [ion binding]; other site 311403012629 Mg2+ binding site [ion binding]; other site 311403012630 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 311403012631 synthetase active site [active] 311403012632 NTP binding site [chemical binding]; other site 311403012633 metal binding site [ion binding]; metal-binding site 311403012634 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 311403012635 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 311403012636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216 311403012637 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 311403012638 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 311403012639 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 311403012640 Catalytic site [active] 311403012641 ribonuclease III; Reviewed; Region: PRK12371 311403012642 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 311403012643 dimerization interface [polypeptide binding]; other site 311403012644 active site 311403012645 metal binding site [ion binding]; metal-binding site 311403012646 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 311403012647 dsRNA binding site [nucleotide binding]; other site 311403012648 GTPase Era; Reviewed; Region: era; PRK00089 311403012649 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 311403012650 G1 box; other site 311403012651 GTP/Mg2+ binding site [chemical binding]; other site 311403012652 Switch I region; other site 311403012653 G2 box; other site 311403012654 Switch II region; other site 311403012655 G3 box; other site 311403012656 G4 box; other site 311403012657 G5 box; other site 311403012658 KH domain; Region: KH_2; pfam07650 311403012659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403012660 Response regulator receiver domain; Region: Response_reg; pfam00072 311403012661 active site 311403012662 phosphorylation site [posttranslational modification] 311403012663 intermolecular recognition site; other site 311403012664 dimerization interface [polypeptide binding]; other site 311403012665 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 311403012666 Recombination protein O N terminal; Region: RecO_N; pfam11967 311403012667 Recombination protein O C terminal; Region: RecO_C; pfam02565 311403012668 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 311403012669 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 311403012670 MOSC domain; Region: MOSC; pfam03473 311403012671 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 311403012672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 311403012673 Zn2+ binding site [ion binding]; other site 311403012674 Mg2+ binding site [ion binding]; other site 311403012675 Predicted membrane protein [Function unknown]; Region: COG5373 311403012676 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 311403012677 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 311403012678 E-class dimer interface [polypeptide binding]; other site 311403012679 P-class dimer interface [polypeptide binding]; other site 311403012680 active site 311403012681 Cu2+ binding site [ion binding]; other site 311403012682 Zn2+ binding site [ion binding]; other site 311403012683 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 311403012684 EF-hand domain pair; Region: EF_hand_5; pfam13499 311403012685 Ca2+ binding site [ion binding]; other site 311403012686 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 311403012687 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 311403012688 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 311403012689 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 311403012690 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403012691 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 311403012692 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 311403012693 nudix motif; other site 311403012694 hypothetical protein; Provisional; Region: PRK02237 311403012695 Uncharacterized conserved protein [Function unknown]; Region: COG2135 311403012696 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 311403012697 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 311403012698 CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009 311403012699 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 311403012700 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 311403012701 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 311403012702 active site 311403012703 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403012704 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 311403012705 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 311403012706 Walker A/P-loop; other site 311403012707 ATP binding site [chemical binding]; other site 311403012708 Q-loop/lid; other site 311403012709 ABC transporter signature motif; other site 311403012710 Walker B; other site 311403012711 D-loop; other site 311403012712 H-loop/switch region; other site 311403012713 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 311403012714 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 311403012715 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 311403012716 Predicted permeases [General function prediction only]; Region: RarD; COG2962 311403012717 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 311403012718 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 311403012719 active site 311403012720 catalytic residues [active] 311403012721 metal binding site [ion binding]; metal-binding site 311403012722 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 311403012723 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 311403012724 Uncharacterized conserved protein [Function unknown]; Region: COG3791 311403012725 Uncharacterized conserved protein [Function unknown]; Region: COG3791 311403012726 Uncharacterized conserved protein [Function unknown]; Region: COG3791 311403012727 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 311403012728 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 311403012729 active site 311403012730 HIGH motif; other site 311403012731 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 311403012732 KMSKS motif; other site 311403012733 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 311403012734 anticodon binding site; other site 311403012735 tRNA binding surface [nucleotide binding]; other site 311403012736 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403012737 classical (c) SDRs; Region: SDR_c; cd05233 311403012738 NAD(P) binding site [chemical binding]; other site 311403012739 active site 311403012740 amidophosphoribosyltransferase; Provisional; Region: PRK09123 311403012741 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 311403012742 active site 311403012743 tetramer interface [polypeptide binding]; other site 311403012744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403012745 active site 311403012746 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 311403012747 Colicin V production protein; Region: Colicin_V; pfam02674 311403012748 DNA repair protein RadA; Provisional; Region: PRK11823 311403012749 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 311403012750 Walker A motif/ATP binding site; other site 311403012751 ATP binding site [chemical binding]; other site 311403012752 Walker B motif; other site 311403012753 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 311403012754 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403012755 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 311403012756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 311403012757 active site 311403012758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 311403012759 dimer interface [polypeptide binding]; other site 311403012760 substrate binding site [chemical binding]; other site 311403012761 catalytic residues [active] 311403012762 replicative DNA helicase; Provisional; Region: PRK09165 311403012763 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 311403012764 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 311403012765 Walker A motif; other site 311403012766 ATP binding site [chemical binding]; other site 311403012767 Walker B motif; other site 311403012768 DNA binding loops [nucleotide binding] 311403012769 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403012770 MarR family; Region: MarR_2; pfam12802 311403012771 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 311403012772 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 311403012773 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403012774 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403012775 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 311403012776 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 311403012777 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 311403012778 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 311403012779 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 311403012780 Predicted periplasmic protein [Function unknown]; Region: COG3904 311403012781 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 311403012782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403012783 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403012784 active site 311403012785 catalytic tetrad [active] 311403012786 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 311403012787 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 311403012788 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 311403012789 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 311403012790 NAD(P) binding site [chemical binding]; other site 311403012791 homotetramer interface [polypeptide binding]; other site 311403012792 homodimer interface [polypeptide binding]; other site 311403012793 active site 311403012794 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 311403012795 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 311403012796 dimer interface [polypeptide binding]; other site 311403012797 active site 311403012798 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 311403012799 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 311403012800 dimerization interface [polypeptide binding]; other site 311403012801 hypothetical protein; Provisional; Region: PRK11820 311403012802 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 311403012803 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 311403012804 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 311403012805 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 311403012806 catalytic site [active] 311403012807 G-X2-G-X-G-K; other site 311403012808 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 311403012809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403012810 S-adenosylmethionine binding site [chemical binding]; other site 311403012811 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 311403012812 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 311403012813 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 311403012814 SurA N-terminal domain; Region: SurA_N; pfam09312 311403012815 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 311403012816 Organic solvent tolerance protein; Region: OstA_C; pfam04453 311403012817 Predicted permeases [General function prediction only]; Region: COG0795 311403012818 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 311403012819 Predicted permeases [General function prediction only]; Region: COG0795 311403012820 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 311403012821 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 311403012822 active site 311403012823 multifunctional aminopeptidase A; Provisional; Region: PRK00913 311403012824 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 311403012825 interface (dimer of trimers) [polypeptide binding]; other site 311403012826 Substrate-binding/catalytic site; other site 311403012827 Zn-binding sites [ion binding]; other site 311403012828 DNA polymerase III subunit chi; Validated; Region: PRK05728 311403012829 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 311403012830 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403012831 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403012832 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 311403012833 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 311403012834 DctM-like transporters; Region: DctM; pfam06808 311403012835 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 311403012836 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 311403012837 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 311403012838 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 311403012839 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403012840 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 311403012841 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 311403012842 NodB motif; other site 311403012843 active site 311403012844 catalytic site [active] 311403012845 metal binding site [ion binding]; metal-binding site 311403012846 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 311403012847 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403012848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403012849 ABC transporter; Region: ABC_tran_2; pfam12848 311403012850 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403012851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 311403012852 DinB superfamily; Region: DinB_2; pfam12867 311403012853 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 311403012854 active site 311403012855 multimer interface [polypeptide binding]; other site 311403012856 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 311403012857 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 311403012858 CGNR zinc finger; Region: zf-CGNR; pfam11706 311403012859 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403012860 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403012861 TM-ABC transporter signature motif; other site 311403012862 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 311403012863 MoaE homodimer interface [polypeptide binding]; other site 311403012864 MoaD interaction [polypeptide binding]; other site 311403012865 active site residues [active] 311403012866 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 311403012867 MoaE interaction surface [polypeptide binding]; other site 311403012868 MoeB interaction surface [polypeptide binding]; other site 311403012869 thiocarboxylated glycine; other site 311403012870 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 311403012871 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 311403012872 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 311403012873 GIY-YIG motif/motif A; other site 311403012874 active site 311403012875 catalytic site [active] 311403012876 putative DNA binding site [nucleotide binding]; other site 311403012877 metal binding site [ion binding]; metal-binding site 311403012878 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 311403012879 short chain dehydrogenase; Provisional; Region: PRK09134 311403012880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403012881 NAD(P) binding site [chemical binding]; other site 311403012882 active site 311403012883 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 311403012884 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403012885 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 311403012886 putative C-terminal domain interface [polypeptide binding]; other site 311403012887 putative GSH binding site (G-site) [chemical binding]; other site 311403012888 putative dimer interface [polypeptide binding]; other site 311403012889 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 311403012890 dimer interface [polypeptide binding]; other site 311403012891 N-terminal domain interface [polypeptide binding]; other site 311403012892 putative substrate binding pocket (H-site) [chemical binding]; other site 311403012893 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 311403012894 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 311403012895 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 311403012896 putative [4Fe-4S] binding site [ion binding]; other site 311403012897 putative molybdopterin cofactor binding site [chemical binding]; other site 311403012898 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 311403012899 putative molybdopterin cofactor binding site; other site 311403012900 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 311403012901 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 311403012902 dimer interface [polypeptide binding]; other site 311403012903 ADP-ribose binding site [chemical binding]; other site 311403012904 active site 311403012905 nudix motif; other site 311403012906 metal binding site [ion binding]; metal-binding site 311403012907 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 311403012908 Amidohydrolase; Region: Amidohydro_5; pfam13594 311403012909 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403012910 active site 311403012911 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 311403012912 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 311403012913 active site 311403012914 substrate binding site [chemical binding]; other site 311403012915 cosubstrate binding site; other site 311403012916 catalytic site [active] 311403012917 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 311403012918 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 311403012919 dimerization interface [polypeptide binding]; other site 311403012920 putative ATP binding site [chemical binding]; other site 311403012921 Domain of unknown function DUF20; Region: UPF0118; pfam01594 311403012922 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 311403012923 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 311403012924 hypothetical protein; Validated; Region: PRK09087 311403012925 polyphosphate kinase; Provisional; Region: PRK05443 311403012926 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 311403012927 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 311403012928 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 311403012929 putative domain interface [polypeptide binding]; other site 311403012930 putative active site [active] 311403012931 catalytic site [active] 311403012932 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 311403012933 putative domain interface [polypeptide binding]; other site 311403012934 putative active site [active] 311403012935 catalytic site [active] 311403012936 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 311403012937 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 311403012938 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 311403012939 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 311403012940 cyclase homology domain; Region: CHD; cd07302 311403012941 nucleotidyl binding site; other site 311403012942 metal binding site [ion binding]; metal-binding site 311403012943 dimer interface [polypeptide binding]; other site 311403012944 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 311403012945 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 311403012946 catalytic site [active] 311403012947 putative active site [active] 311403012948 putative substrate binding site [chemical binding]; other site 311403012949 HRDC domain; Region: HRDC; pfam00570 311403012950 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 311403012951 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 311403012952 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 311403012953 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 311403012954 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 311403012955 dimer interface [polypeptide binding]; other site 311403012956 anticodon binding site; other site 311403012957 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 311403012958 homodimer interface [polypeptide binding]; other site 311403012959 motif 1; other site 311403012960 active site 311403012961 motif 2; other site 311403012962 GAD domain; Region: GAD; pfam02938 311403012963 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 311403012964 active site 311403012965 motif 3; other site 311403012966 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 311403012967 Beta-lactamase; Region: Beta-lactamase; pfam00144 311403012968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403012969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403012970 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 311403012971 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 311403012972 CAP-like domain; other site 311403012973 active site 311403012974 primary dimer interface [polypeptide binding]; other site 311403012975 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 311403012976 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 311403012977 putative addiction module antidote; Region: doc_partner; TIGR02609 311403012978 EamA-like transporter family; Region: EamA; pfam00892 311403012979 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 311403012980 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 311403012981 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 311403012982 Predicted membrane protein/domain [Function unknown]; Region: COG1714 311403012983 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 311403012984 dimer interface [polypeptide binding]; other site 311403012985 allosteric magnesium binding site [ion binding]; other site 311403012986 active site 311403012987 aspartate-rich active site metal binding site; other site 311403012988 Schiff base residues; other site 311403012989 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403012990 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 311403012991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 311403012992 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403012993 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403012994 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 311403012995 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 311403012996 dimer interface [polypeptide binding]; other site 311403012997 active site 311403012998 glycine-pyridoxal phosphate binding site [chemical binding]; other site 311403012999 folate binding site [chemical binding]; other site 311403013000 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 311403013001 ATP cone domain; Region: ATP-cone; pfam03477 311403013002 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 311403013003 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 311403013004 catalytic motif [active] 311403013005 Zn binding site [ion binding]; other site 311403013006 RibD C-terminal domain; Region: RibD_C; cl17279 311403013007 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 311403013008 Lumazine binding domain; Region: Lum_binding; pfam00677 311403013009 Lumazine binding domain; Region: Lum_binding; pfam00677 311403013010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403013011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403013012 Coenzyme A binding pocket [chemical binding]; other site 311403013013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403013014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403013015 Cupin domain; Region: Cupin_2; cl17218 311403013016 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 311403013017 homopentamer interface [polypeptide binding]; other site 311403013018 active site 311403013019 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 311403013020 putative RNA binding site [nucleotide binding]; other site 311403013021 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808 311403013022 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 311403013023 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 311403013024 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 311403013025 Uncharacterized conserved protein [Function unknown]; Region: COG5452 311403013026 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 311403013027 putative phosphate acyltransferase; Provisional; Region: PRK05331 311403013028 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 311403013029 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 311403013030 dimer interface [polypeptide binding]; other site 311403013031 active site 311403013032 CoA binding pocket [chemical binding]; other site 311403013033 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 311403013034 IHF dimer interface [polypeptide binding]; other site 311403013035 IHF - DNA interface [nucleotide binding]; other site 311403013036 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 311403013037 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 311403013038 DNA binding residues [nucleotide binding] 311403013039 Porin subfamily; Region: Porin_2; pfam02530 311403013040 BA14K-like protein; Region: BA14K; pfam07886 311403013041 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 311403013042 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 311403013043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3742 311403013044 putative active site [active] 311403013045 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 311403013046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 311403013047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403013048 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 311403013049 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 311403013050 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 311403013051 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 311403013052 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 311403013053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403013054 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 311403013055 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 311403013056 SLBB domain; Region: SLBB; pfam10531 311403013057 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 311403013058 Chain length determinant protein; Region: Wzz; pfam02706 311403013059 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 311403013060 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 311403013061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 311403013062 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 311403013063 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 311403013064 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 311403013065 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 311403013066 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 311403013067 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 311403013068 agmatinase; Region: agmatinase; TIGR01230 311403013069 oligomer interface [polypeptide binding]; other site 311403013070 putative active site [active] 311403013071 Mn binding site [ion binding]; other site 311403013072 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 311403013073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403013074 putative substrate translocation pore; other site 311403013075 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 311403013076 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 311403013077 23S rRNA interface [nucleotide binding]; other site 311403013078 L3 interface [polypeptide binding]; other site 311403013079 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 311403013080 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 311403013081 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 311403013082 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 311403013083 homodimer interface [polypeptide binding]; other site 311403013084 substrate-cofactor binding pocket; other site 311403013085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403013086 catalytic residue [active] 311403013087 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 311403013088 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 311403013089 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 311403013090 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 311403013091 PBP superfamily domain; Region: PBP_like_2; cl17296 311403013092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013093 dimer interface [polypeptide binding]; other site 311403013094 conserved gate region; other site 311403013095 putative PBP binding loops; other site 311403013096 ABC-ATPase subunit interface; other site 311403013097 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 311403013098 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 311403013099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013100 dimer interface [polypeptide binding]; other site 311403013101 conserved gate region; other site 311403013102 putative PBP binding loops; other site 311403013103 ABC-ATPase subunit interface; other site 311403013104 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 311403013105 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 311403013106 Walker A/P-loop; other site 311403013107 ATP binding site [chemical binding]; other site 311403013108 Q-loop/lid; other site 311403013109 ABC transporter signature motif; other site 311403013110 Walker B; other site 311403013111 D-loop; other site 311403013112 H-loop/switch region; other site 311403013113 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 311403013114 Cytochrome P450; Region: p450; cl12078 311403013115 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403013116 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403013117 metal binding site [ion binding]; metal-binding site 311403013118 active site 311403013119 I-site; other site 311403013120 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 311403013121 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 311403013122 oligomer interface [polypeptide binding]; other site 311403013123 active site residues [active] 311403013124 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 311403013125 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 311403013126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403013127 Walker A motif; other site 311403013128 ATP binding site [chemical binding]; other site 311403013129 Walker B motif; other site 311403013130 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 311403013131 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 311403013132 Found in ATP-dependent protease La (LON); Region: LON; smart00464 311403013133 Found in ATP-dependent protease La (LON); Region: LON; smart00464 311403013134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403013135 Walker A motif; other site 311403013136 ATP binding site [chemical binding]; other site 311403013137 Walker B motif; other site 311403013138 arginine finger; other site 311403013139 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 311403013140 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 311403013141 IHF dimer interface [polypeptide binding]; other site 311403013142 IHF - DNA interface [nucleotide binding]; other site 311403013143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403013144 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403013145 NAD(P) binding site [chemical binding]; other site 311403013146 active site 311403013147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403013148 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403013149 active site 311403013150 catalytic tetrad [active] 311403013151 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 311403013152 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403013153 active site 311403013154 metal binding site [ion binding]; metal-binding site 311403013155 DNA binding site [nucleotide binding] 311403013156 AAA domain; Region: AAA_23; pfam13476 311403013157 AAA domain; Region: AAA_27; pfam13514 311403013158 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 311403013159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 311403013160 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 311403013161 active site 311403013162 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403013163 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 311403013164 Probable Catalytic site; other site 311403013165 metal-binding site 311403013166 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 311403013167 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 311403013168 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 311403013169 NADH dehydrogenase subunit B; Validated; Region: PRK06411 311403013170 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 311403013171 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 311403013172 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 311403013173 NADH dehydrogenase subunit D; Validated; Region: PRK06075 311403013174 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 311403013175 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 311403013176 putative dimer interface [polypeptide binding]; other site 311403013177 [2Fe-2S] cluster binding site [ion binding]; other site 311403013178 Uncharacterized conserved protein [Function unknown]; Region: COG3743 311403013179 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 311403013180 SLBB domain; Region: SLBB; pfam10531 311403013181 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 311403013182 Uncharacterized conserved protein [Function unknown]; Region: COG3743 311403013183 NADH dehydrogenase subunit G; Validated; Region: PRK09130 311403013184 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403013185 catalytic loop [active] 311403013186 iron binding site [ion binding]; other site 311403013187 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 311403013188 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 311403013189 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 311403013190 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 311403013191 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 311403013192 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 311403013193 4Fe-4S binding domain; Region: Fer4; pfam00037 311403013194 4Fe-4S binding domain; Region: Fer4; pfam00037 311403013195 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 311403013196 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 311403013197 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 311403013198 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 311403013199 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 311403013200 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 311403013201 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 311403013202 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 311403013203 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 311403013204 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 311403013205 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 311403013206 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 311403013207 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 311403013208 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 311403013209 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 311403013210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 311403013211 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 311403013212 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403013213 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 311403013214 dimer interface [polypeptide binding]; other site 311403013215 substrate binding site [chemical binding]; other site 311403013216 metal binding site [ion binding]; metal-binding site 311403013217 Protein of unknown function (DUF1467); Region: DUF1467; cl11569 311403013218 prolyl-tRNA synthetase; Provisional; Region: PRK12325 311403013219 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 311403013220 dimer interface [polypeptide binding]; other site 311403013221 motif 1; other site 311403013222 active site 311403013223 motif 2; other site 311403013224 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 311403013225 active site 311403013226 motif 3; other site 311403013227 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 311403013228 anticodon binding site; other site 311403013229 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 311403013230 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 311403013231 FtsX-like permease family; Region: FtsX; pfam02687 311403013232 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 311403013233 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 311403013234 Walker A/P-loop; other site 311403013235 ATP binding site [chemical binding]; other site 311403013236 Q-loop/lid; other site 311403013237 ABC transporter signature motif; other site 311403013238 Walker B; other site 311403013239 D-loop; other site 311403013240 H-loop/switch region; other site 311403013241 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 311403013242 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 311403013243 putative active site [active] 311403013244 putative PHP Thumb interface [polypeptide binding]; other site 311403013245 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 311403013246 generic binding surface II; other site 311403013247 generic binding surface I; other site 311403013248 hypothetical protein; Provisional; Region: PRK06132 311403013249 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403013250 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403013251 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 311403013252 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 311403013253 TPR repeat; Region: TPR_11; pfam13414 311403013254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403013255 binding surface 311403013256 TPR motif; other site 311403013257 DNA polymerase IV; Provisional; Region: PRK02794 311403013258 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 311403013259 active site 311403013260 DNA binding site [nucleotide binding] 311403013261 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 311403013262 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 311403013263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403013264 active site 311403013265 phosphorylation site [posttranslational modification] 311403013266 intermolecular recognition site; other site 311403013267 dimerization interface [polypeptide binding]; other site 311403013268 response regulator PleD; Reviewed; Region: pleD; PRK09581 311403013269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403013270 active site 311403013271 phosphorylation site [posttranslational modification] 311403013272 intermolecular recognition site; other site 311403013273 dimerization interface [polypeptide binding]; other site 311403013274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403013275 active site 311403013276 phosphorylation site [posttranslational modification] 311403013277 intermolecular recognition site; other site 311403013278 dimerization interface [polypeptide binding]; other site 311403013279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403013280 metal binding site [ion binding]; metal-binding site 311403013281 active site 311403013282 I-site; other site 311403013283 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 311403013284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403013285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403013286 putative substrate translocation pore; other site 311403013287 hypothetical protein; Provisional; Region: PRK05978 311403013288 ribonuclease R; Region: RNase_R; TIGR02063 311403013289 RNB domain; Region: RNB; pfam00773 311403013290 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 311403013291 RNA binding site [nucleotide binding]; other site 311403013292 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 311403013293 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 311403013294 active site 311403013295 interdomain interaction site; other site 311403013296 putative metal-binding site [ion binding]; other site 311403013297 nucleotide binding site [chemical binding]; other site 311403013298 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 311403013299 domain I; other site 311403013300 DNA binding groove [nucleotide binding] 311403013301 phosphate binding site [ion binding]; other site 311403013302 domain II; other site 311403013303 domain III; other site 311403013304 nucleotide binding site [chemical binding]; other site 311403013305 catalytic site [active] 311403013306 domain IV; other site 311403013307 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 311403013308 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 311403013309 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 311403013310 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 311403013311 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 311403013312 DNA protecting protein DprA; Region: dprA; TIGR00732 311403013313 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 311403013314 dihydroorotase; Validated; Region: PRK09059 311403013315 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403013316 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 311403013317 active site 311403013318 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 311403013319 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 311403013320 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 311403013321 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 311403013322 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403013323 active site 311403013324 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 311403013325 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 311403013326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403013327 Coenzyme A binding pocket [chemical binding]; other site 311403013328 Peptidase family U32; Region: Peptidase_U32; cl03113 311403013329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403013330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403013331 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 311403013332 metal-dependent hydrolase; Provisional; Region: PRK00685 311403013333 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 311403013334 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 311403013335 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 311403013336 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 311403013337 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 311403013338 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 311403013339 hypothetical protein; Provisional; Region: PRK13687 311403013340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403013341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 311403013342 Coenzyme A binding pocket [chemical binding]; other site 311403013343 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 311403013344 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 311403013345 GatB domain; Region: GatB_Yqey; smart00845 311403013346 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403013347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403013348 Coenzyme A binding pocket [chemical binding]; other site 311403013349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403013350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403013351 Coenzyme A binding pocket [chemical binding]; other site 311403013352 NADH dehydrogenase; Validated; Region: PRK08183 311403013353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765 311403013354 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 311403013355 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 311403013356 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 311403013357 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 311403013358 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403013359 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403013360 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 311403013361 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 311403013362 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403013363 carboxyltransferase (CT) interaction site; other site 311403013364 biotinylation site [posttranslational modification]; other site 311403013365 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 311403013366 Dehydroquinase class II; Region: DHquinase_II; pfam01220 311403013367 trimer interface [polypeptide binding]; other site 311403013368 active site 311403013369 dimer interface [polypeptide binding]; other site 311403013370 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 311403013371 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 311403013372 catalytic residues [active] 311403013373 aspartate aminotransferase; Provisional; Region: PRK05764 311403013374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403013375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403013376 homodimer interface [polypeptide binding]; other site 311403013377 catalytic residue [active] 311403013378 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 311403013379 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 311403013380 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 311403013381 AMIN domain; Region: AMIN; pfam11741 311403013382 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 311403013383 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 311403013384 active site 311403013385 metal binding site [ion binding]; metal-binding site 311403013386 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 311403013387 Transglycosylase; Region: Transgly; pfam00912 311403013388 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 311403013389 peptide chain release factor 2; Provisional; Region: PRK07342 311403013390 This domain is found in peptide chain release factors; Region: PCRF; smart00937 311403013391 RF-1 domain; Region: RF-1; pfam00472 311403013392 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 311403013393 ATP-NAD kinase; Region: NAD_kinase; pfam01513 311403013394 Methyltransferase domain; Region: Methyltransf_24; pfam13578 311403013395 Protease inhibitor Inh; Region: Inh; pfam02974 311403013396 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 311403013397 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 311403013398 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 311403013399 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 311403013400 elongation factor Tu; Reviewed; Region: PRK00049 311403013401 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 311403013402 G1 box; other site 311403013403 GEF interaction site [polypeptide binding]; other site 311403013404 GTP/Mg2+ binding site [chemical binding]; other site 311403013405 Switch I region; other site 311403013406 G2 box; other site 311403013407 G3 box; other site 311403013408 Switch II region; other site 311403013409 G4 box; other site 311403013410 G5 box; other site 311403013411 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 311403013412 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 311403013413 Antibiotic Binding Site [chemical binding]; other site 311403013414 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 311403013415 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403013416 extended (e) SDRs; Region: SDR_e; cd08946 311403013417 NAD(P) binding site [chemical binding]; other site 311403013418 active site 311403013419 substrate binding site [chemical binding]; other site 311403013420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 311403013421 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 311403013422 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 311403013423 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 311403013424 putative homodimer interface [polypeptide binding]; other site 311403013425 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 311403013426 heterodimer interface [polypeptide binding]; other site 311403013427 homodimer interface [polypeptide binding]; other site 311403013428 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 311403013429 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 311403013430 23S rRNA interface [nucleotide binding]; other site 311403013431 L7/L12 interface [polypeptide binding]; other site 311403013432 putative thiostrepton binding site; other site 311403013433 L25 interface [polypeptide binding]; other site 311403013434 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 311403013435 mRNA/rRNA interface [nucleotide binding]; other site 311403013436 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 311403013437 23S rRNA interface [nucleotide binding]; other site 311403013438 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 311403013439 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 311403013440 L11 interface [polypeptide binding]; other site 311403013441 putative EF-Tu interaction site [polypeptide binding]; other site 311403013442 putative EF-G interaction site [polypeptide binding]; other site 311403013443 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 311403013444 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 311403013445 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 311403013446 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 311403013447 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 311403013448 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 311403013449 RPB1 interaction site [polypeptide binding]; other site 311403013450 RPB11 interaction site [polypeptide binding]; other site 311403013451 RPB10 interaction site [polypeptide binding]; other site 311403013452 RPB3 interaction site [polypeptide binding]; other site 311403013453 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 311403013454 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 311403013455 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 311403013456 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 311403013457 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 311403013458 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 311403013459 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 311403013460 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 311403013461 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 311403013462 DNA binding site [nucleotide binding] 311403013463 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 311403013464 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 311403013465 S17 interaction site [polypeptide binding]; other site 311403013466 S8 interaction site; other site 311403013467 16S rRNA interaction site [nucleotide binding]; other site 311403013468 streptomycin interaction site [chemical binding]; other site 311403013469 23S rRNA interaction site [nucleotide binding]; other site 311403013470 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 311403013471 30S ribosomal protein S7; Validated; Region: PRK05302 311403013472 elongation factor G; Reviewed; Region: PRK00007 311403013473 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 311403013474 G1 box; other site 311403013475 putative GEF interaction site [polypeptide binding]; other site 311403013476 GTP/Mg2+ binding site [chemical binding]; other site 311403013477 Switch I region; other site 311403013478 G2 box; other site 311403013479 G3 box; other site 311403013480 Switch II region; other site 311403013481 G4 box; other site 311403013482 G5 box; other site 311403013483 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 311403013484 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 311403013485 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 311403013486 elongation factor Tu; Reviewed; Region: PRK00049 311403013487 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 311403013488 G1 box; other site 311403013489 GEF interaction site [polypeptide binding]; other site 311403013490 GTP/Mg2+ binding site [chemical binding]; other site 311403013491 Switch I region; other site 311403013492 G2 box; other site 311403013493 G3 box; other site 311403013494 Switch II region; other site 311403013495 G4 box; other site 311403013496 G5 box; other site 311403013497 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 311403013498 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 311403013499 Antibiotic Binding Site [chemical binding]; other site 311403013500 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 311403013501 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 311403013502 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 311403013503 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 311403013504 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 311403013505 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 311403013506 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 311403013507 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 311403013508 putative translocon binding site; other site 311403013509 protein-rRNA interface [nucleotide binding]; other site 311403013510 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 311403013511 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 311403013512 G-X-X-G motif; other site 311403013513 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 311403013514 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 311403013515 23S rRNA interface [nucleotide binding]; other site 311403013516 5S rRNA interface [nucleotide binding]; other site 311403013517 putative antibiotic binding site [chemical binding]; other site 311403013518 L25 interface [polypeptide binding]; other site 311403013519 L27 interface [polypeptide binding]; other site 311403013520 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 311403013521 23S rRNA interface [nucleotide binding]; other site 311403013522 putative translocon interaction site; other site 311403013523 signal recognition particle (SRP54) interaction site; other site 311403013524 L23 interface [polypeptide binding]; other site 311403013525 trigger factor interaction site; other site 311403013526 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 311403013527 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 311403013528 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 311403013529 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 311403013530 RNA binding site [nucleotide binding]; other site 311403013531 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 311403013532 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 311403013533 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 311403013534 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 311403013535 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 311403013536 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 311403013537 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 311403013538 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 311403013539 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 311403013540 23S rRNA interface [nucleotide binding]; other site 311403013541 L21e interface [polypeptide binding]; other site 311403013542 5S rRNA interface [nucleotide binding]; other site 311403013543 L27 interface [polypeptide binding]; other site 311403013544 L5 interface [polypeptide binding]; other site 311403013545 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 311403013546 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 311403013547 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 311403013548 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 311403013549 SecY translocase; Region: SecY; pfam00344 311403013550 adenylate kinase; Reviewed; Region: adk; PRK00279 311403013551 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 311403013552 AMP-binding site [chemical binding]; other site 311403013553 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 311403013554 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 311403013555 30S ribosomal protein S13; Region: bact_S13; TIGR03631 311403013556 30S ribosomal protein S11; Validated; Region: PRK05309 311403013557 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 311403013558 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 311403013559 alphaNTD homodimer interface [polypeptide binding]; other site 311403013560 alphaNTD - beta interaction site [polypeptide binding]; other site 311403013561 alphaNTD - beta' interaction site [polypeptide binding]; other site 311403013562 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 311403013563 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 311403013564 Protein of unknown function (DUF817); Region: DUF817; cl01520 311403013565 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 311403013566 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403013567 MarR family; Region: MarR_2; cl17246 311403013568 Fusaric acid resistance protein family; Region: FUSC; pfam04632 311403013569 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 311403013570 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 311403013571 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 311403013572 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403013573 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403013574 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 311403013575 TMAO/DMSO reductase; Reviewed; Region: PRK05363 311403013576 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 311403013577 Moco binding site; other site 311403013578 metal coordination site [ion binding]; other site 311403013579 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 311403013580 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 311403013581 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 311403013582 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 311403013583 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403013584 protein binding site [polypeptide binding]; other site 311403013585 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403013586 protein binding site [polypeptide binding]; other site 311403013587 recombination factor protein RarA; Reviewed; Region: PRK13342 311403013588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403013589 Walker A motif; other site 311403013590 ATP binding site [chemical binding]; other site 311403013591 Walker B motif; other site 311403013592 arginine finger; other site 311403013593 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 311403013594 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 311403013595 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 311403013596 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 311403013597 dimer interface [polypeptide binding]; other site 311403013598 active site 311403013599 catalytic residue [active] 311403013600 SnoaL-like domain; Region: SnoaL_3; pfam13474 311403013601 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403013602 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 311403013603 DNA binding residues [nucleotide binding] 311403013604 dimerization interface [polypeptide binding]; other site 311403013605 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 311403013606 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 311403013607 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 311403013608 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 311403013609 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 311403013610 ligand binding site [chemical binding]; other site 311403013611 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 311403013612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403013613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403013614 Walker A/P-loop; other site 311403013615 ATP binding site [chemical binding]; other site 311403013616 Q-loop/lid; other site 311403013617 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403013618 ABC transporter signature motif; other site 311403013619 Walker B; other site 311403013620 D-loop; other site 311403013621 ABC transporter; Region: ABC_tran_2; pfam12848 311403013622 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403013623 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 311403013624 Domain of unknown function DUF21; Region: DUF21; pfam01595 311403013625 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 311403013626 Transporter associated domain; Region: CorC_HlyC; smart01091 311403013627 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 311403013628 Protein of unknown function (DUF1402); Region: DUF1402; pfam07182 311403013629 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 311403013630 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 311403013631 metal-binding site [ion binding] 311403013632 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 311403013633 Soluble P-type ATPase [General function prediction only]; Region: COG4087 311403013634 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 311403013635 DNA binding residues [nucleotide binding] 311403013636 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 311403013637 dimer interface [polypeptide binding]; other site 311403013638 putative metal binding site [ion binding]; other site 311403013639 Protein of unknown function (DUF2026); Region: DUF2026; pfam09641 311403013640 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 311403013641 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 311403013642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403013643 motif II; other site 311403013644 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 311403013645 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 311403013646 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 311403013647 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 311403013648 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 311403013649 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 311403013650 TSCPD domain; Region: TSCPD; pfam12637 311403013651 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403013652 active site 311403013653 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 311403013654 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 311403013655 Ligand Binding Site [chemical binding]; other site 311403013656 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 311403013657 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 311403013658 putative MPT binding site; other site 311403013659 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 311403013660 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403013661 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 311403013662 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 311403013663 substrate binding site [chemical binding]; other site 311403013664 hexamer interface [polypeptide binding]; other site 311403013665 metal binding site [ion binding]; metal-binding site 311403013666 threonine dehydratase; Validated; Region: PRK08639 311403013667 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 311403013668 tetramer interface [polypeptide binding]; other site 311403013669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403013670 catalytic residue [active] 311403013671 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 311403013672 Transcriptional activator HlyU; Region: HlyU; pfam10115 311403013673 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 311403013674 short chain dehydrogenase; Provisional; Region: PRK06500 311403013675 classical (c) SDRs; Region: SDR_c; cd05233 311403013676 NAD(P) binding site [chemical binding]; other site 311403013677 active site 311403013678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403013679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403013680 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 311403013681 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403013682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403013683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403013684 LysR substrate binding domain; Region: LysR_substrate; pfam03466 311403013685 dimerization interface [polypeptide binding]; other site 311403013686 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 311403013687 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 311403013688 active site 311403013689 metal binding site [ion binding]; metal-binding site 311403013690 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 311403013691 PilZ domain; Region: PilZ; pfam07238 311403013692 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 311403013693 putative catalytic site [active] 311403013694 putative metal binding site [ion binding]; other site 311403013695 putative phosphate binding site [ion binding]; other site 311403013696 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403013697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403013698 putative DNA binding site [nucleotide binding]; other site 311403013699 putative Zn2+ binding site [ion binding]; other site 311403013700 AsnC family; Region: AsnC_trans_reg; pfam01037 311403013701 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 311403013702 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 311403013703 hexamer interface [polypeptide binding]; other site 311403013704 ligand binding site [chemical binding]; other site 311403013705 putative active site [active] 311403013706 NAD(P) binding site [chemical binding]; other site 311403013707 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 311403013708 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 311403013709 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 311403013710 active site residue [active] 311403013711 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 311403013712 active site residue [active] 311403013713 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 311403013714 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 311403013715 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 311403013716 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 311403013717 dimer interface [polypeptide binding]; other site 311403013718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403013719 catalytic residue [active] 311403013720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403013721 short chain dehydrogenase; Provisional; Region: PRK07024 311403013722 NAD(P) binding site [chemical binding]; other site 311403013723 active site 311403013724 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403013725 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403013726 Walker A/P-loop; other site 311403013727 ATP binding site [chemical binding]; other site 311403013728 Q-loop/lid; other site 311403013729 ABC transporter signature motif; other site 311403013730 Walker B; other site 311403013731 D-loop; other site 311403013732 H-loop/switch region; other site 311403013733 TOBE domain; Region: TOBE_2; pfam08402 311403013734 Tannase and feruloyl esterase; Region: Tannase; pfam07519 311403013735 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403013736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013737 dimer interface [polypeptide binding]; other site 311403013738 conserved gate region; other site 311403013739 putative PBP binding loops; other site 311403013740 ABC-ATPase subunit interface; other site 311403013741 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 311403013742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013743 putative PBP binding loops; other site 311403013744 ABC-ATPase subunit interface; other site 311403013745 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403013746 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403013747 maltose O-acetyltransferase; Provisional; Region: PRK10092 311403013748 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 311403013749 active site 311403013750 substrate binding site [chemical binding]; other site 311403013751 trimer interface [polypeptide binding]; other site 311403013752 CoA binding site [chemical binding]; other site 311403013753 Porin subfamily; Region: Porin_2; pfam02530 311403013754 Protein of unknown function (DUF982); Region: DUF982; pfam06169 311403013755 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 311403013756 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 311403013757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403013758 S-adenosylmethionine binding site [chemical binding]; other site 311403013759 Protein of unknown function (DUF2497); Region: DUF2497; cl11534 311403013760 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 311403013761 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 311403013762 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 311403013763 HIGH motif; other site 311403013764 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 311403013765 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 311403013766 active site 311403013767 KMSKS motif; other site 311403013768 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 311403013769 tRNA binding surface [nucleotide binding]; other site 311403013770 anticodon binding site; other site 311403013771 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 311403013772 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 311403013773 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403013774 Sel1-like repeats; Region: SEL1; smart00671 311403013775 Sel1-like repeats; Region: SEL1; smart00671 311403013776 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 311403013777 putative catalytic site [active] 311403013778 putative phosphate binding site [ion binding]; other site 311403013779 active site 311403013780 metal binding site A [ion binding]; metal-binding site 311403013781 DNA binding site [nucleotide binding] 311403013782 putative AP binding site [nucleotide binding]; other site 311403013783 putative metal binding site B [ion binding]; other site 311403013784 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 311403013785 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 311403013786 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 311403013787 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 311403013788 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 311403013789 active site 311403013790 HIGH motif; other site 311403013791 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 311403013792 KMSK motif region; other site 311403013793 tRNA binding surface [nucleotide binding]; other site 311403013794 DALR anticodon binding domain; Region: DALR_1; smart00836 311403013795 anticodon binding site; other site 311403013796 Sporulation related domain; Region: SPOR; pfam05036 311403013797 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 311403013798 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 311403013799 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 311403013800 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 311403013801 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 311403013802 sec-independent translocase; Provisional; Region: PRK00708 311403013803 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 311403013804 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 311403013805 seryl-tRNA synthetase; Provisional; Region: PRK05431 311403013806 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 311403013807 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 311403013808 dimer interface [polypeptide binding]; other site 311403013809 active site 311403013810 motif 1; other site 311403013811 motif 2; other site 311403013812 motif 3; other site 311403013813 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 311403013814 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 311403013815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403013816 S-adenosylmethionine binding site [chemical binding]; other site 311403013817 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 311403013818 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 311403013819 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 311403013820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 311403013821 Peptidase family M23; Region: Peptidase_M23; pfam01551 311403013822 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 311403013823 Protein of unknown function (DUF815); Region: DUF815; pfam05673 311403013824 Walker A motif; other site 311403013825 ATP binding site [chemical binding]; other site 311403013826 Walker B motif; other site 311403013827 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 311403013828 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 311403013829 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 311403013830 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 311403013831 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 311403013832 Protein export membrane protein; Region: SecD_SecF; pfam02355 311403013833 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 311403013834 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 311403013835 substrate binding pocket [chemical binding]; other site 311403013836 substrate-Mg2+ binding site; other site 311403013837 aspartate-rich region 1; other site 311403013838 aspartate-rich region 2; other site 311403013839 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 311403013840 Glucose inhibited division protein A; Region: GIDA; pfam01134 311403013841 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 311403013842 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 311403013843 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 311403013844 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 311403013845 trigger factor; Provisional; Region: tig; PRK01490 311403013846 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 311403013847 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 311403013848 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 311403013849 putative active site [active] 311403013850 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 311403013851 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403013852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403013853 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 311403013854 Putative phosphatase (DUF442); Region: DUF442; cl17385 311403013855 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 311403013856 active site 311403013857 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 311403013858 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 311403013859 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 311403013860 aminotransferase; Validated; Region: PRK09148 311403013861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403013862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403013863 homodimer interface [polypeptide binding]; other site 311403013864 catalytic residue [active] 311403013865 homoserine dehydrogenase; Provisional; Region: PRK06349 311403013866 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 311403013867 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 311403013868 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 311403013869 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 311403013870 DHH family; Region: DHH; pfam01368 311403013871 DHHA1 domain; Region: DHHA1; pfam02272 311403013872 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403013873 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403013874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403013875 DNA-binding site [nucleotide binding]; DNA binding site 311403013876 FCD domain; Region: FCD; pfam07729 311403013877 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403013878 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403013879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013880 dimer interface [polypeptide binding]; other site 311403013881 conserved gate region; other site 311403013882 putative PBP binding loops; other site 311403013883 ABC-ATPase subunit interface; other site 311403013884 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403013885 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403013886 substrate binding pocket [chemical binding]; other site 311403013887 membrane-bound complex binding site; other site 311403013888 hinge residues; other site 311403013889 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403013890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403013891 Walker A/P-loop; other site 311403013892 ATP binding site [chemical binding]; other site 311403013893 Q-loop/lid; other site 311403013894 ABC transporter signature motif; other site 311403013895 Walker B; other site 311403013896 D-loop; other site 311403013897 H-loop/switch region; other site 311403013898 TOBE domain; Region: TOBE_2; pfam08402 311403013899 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 311403013900 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403013901 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 311403013902 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 311403013903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013904 dimer interface [polypeptide binding]; other site 311403013905 conserved gate region; other site 311403013906 putative PBP binding loops; other site 311403013907 ABC-ATPase subunit interface; other site 311403013908 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403013909 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403013910 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 311403013911 active site 311403013912 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 311403013913 Phosphotransferase enzyme family; Region: APH; pfam01636 311403013914 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 311403013915 active site 311403013916 ATP binding site [chemical binding]; other site 311403013917 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 311403013918 RNA/DNA hybrid binding site [nucleotide binding]; other site 311403013919 active site 311403013920 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 311403013921 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 311403013922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403013923 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 311403013924 dimer interface [polypeptide binding]; other site 311403013925 active site 311403013926 metal binding site [ion binding]; metal-binding site 311403013927 glutathione binding site [chemical binding]; other site 311403013928 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403013929 DNA-binding site [nucleotide binding]; DNA binding site 311403013930 RNA-binding motif; other site 311403013931 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403013932 DNA-binding site [nucleotide binding]; DNA binding site 311403013933 RNA-binding motif; other site 311403013934 Uncharacterized conserved protein [Function unknown]; Region: COG1430 311403013935 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 311403013936 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403013937 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403013938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403013939 putative DNA binding site [nucleotide binding]; other site 311403013940 putative Zn2+ binding site [ion binding]; other site 311403013941 AsnC family; Region: AsnC_trans_reg; pfam01037 311403013942 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403013943 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403013944 Walker A/P-loop; other site 311403013945 ATP binding site [chemical binding]; other site 311403013946 Q-loop/lid; other site 311403013947 ABC transporter signature motif; other site 311403013948 Walker B; other site 311403013949 D-loop; other site 311403013950 H-loop/switch region; other site 311403013951 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403013952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013953 dimer interface [polypeptide binding]; other site 311403013954 conserved gate region; other site 311403013955 putative PBP binding loops; other site 311403013956 ABC-ATPase subunit interface; other site 311403013957 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 311403013958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403013959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403013960 putative PBP binding loops; other site 311403013961 dimer interface [polypeptide binding]; other site 311403013962 ABC-ATPase subunit interface; other site 311403013963 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 311403013964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403013965 substrate binding pocket [chemical binding]; other site 311403013966 membrane-bound complex binding site; other site 311403013967 hinge residues; other site 311403013968 cystathionine beta-lyase; Provisional; Region: PRK05967 311403013969 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 311403013970 homodimer interface [polypeptide binding]; other site 311403013971 substrate-cofactor binding pocket; other site 311403013972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403013973 catalytic residue [active] 311403013974 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403013975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 311403013976 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 311403013977 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403013978 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 311403013979 enoyl-CoA hydratase; Provisional; Region: PRK06127 311403013980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 311403013981 substrate binding site [chemical binding]; other site 311403013982 oxyanion hole (OAH) forming residues; other site 311403013983 trimer interface [polypeptide binding]; other site 311403013984 serine acetyltransferase; Provisional; Region: cysE; PRK11132 311403013985 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 311403013986 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 311403013987 trimer interface [polypeptide binding]; other site 311403013988 active site 311403013989 substrate binding site [chemical binding]; other site 311403013990 CoA binding site [chemical binding]; other site 311403013991 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 311403013992 Phasin protein; Region: Phasin_2; pfam09361 311403013993 Uncharacterized conserved protein [Function unknown]; Region: COG2127 311403013994 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 311403013995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403013996 Walker A motif; other site 311403013997 ATP binding site [chemical binding]; other site 311403013998 Walker B motif; other site 311403013999 arginine finger; other site 311403014000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403014001 Walker A motif; other site 311403014002 ATP binding site [chemical binding]; other site 311403014003 Walker B motif; other site 311403014004 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 311403014005 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 311403014006 HIT family signature motif; other site 311403014007 catalytic residue [active] 311403014008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 311403014009 Protein of unknown function, DUF482; Region: DUF482; pfam04339 311403014010 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585 311403014011 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 311403014012 putative active site [active] 311403014013 catalytic site [active] 311403014014 putative metal binding site [ion binding]; other site 311403014015 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 311403014016 homotrimer interaction site [polypeptide binding]; other site 311403014017 putative active site [active] 311403014018 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 311403014019 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 311403014020 rRNA interaction site [nucleotide binding]; other site 311403014021 S8 interaction site; other site 311403014022 putative laminin-1 binding site; other site 311403014023 elongation factor Ts; Provisional; Region: tsf; PRK09377 311403014024 UBA/TS-N domain; Region: UBA; pfam00627 311403014025 Elongation factor TS; Region: EF_TS; pfam00889 311403014026 Elongation factor TS; Region: EF_TS; pfam00889 311403014027 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 311403014028 putative nucleotide binding site [chemical binding]; other site 311403014029 uridine monophosphate binding site [chemical binding]; other site 311403014030 homohexameric interface [polypeptide binding]; other site 311403014031 ribosome recycling factor; Reviewed; Region: frr; PRK00083 311403014032 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 311403014033 hinge region; other site 311403014034 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 311403014035 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 311403014036 catalytic residue [active] 311403014037 putative FPP diphosphate binding site; other site 311403014038 putative FPP binding hydrophobic cleft; other site 311403014039 dimer interface [polypeptide binding]; other site 311403014040 putative IPP diphosphate binding site; other site 311403014041 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 311403014042 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 311403014043 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 311403014044 active site 311403014045 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 311403014046 protein binding site [polypeptide binding]; other site 311403014047 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 311403014048 protein binding site [polypeptide binding]; other site 311403014049 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 311403014050 protein binding site [polypeptide binding]; other site 311403014051 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 311403014052 putative substrate binding region [chemical binding]; other site 311403014053 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 311403014054 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 311403014055 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 311403014056 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 311403014057 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 311403014058 Surface antigen; Region: Bac_surface_Ag; pfam01103 311403014059 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 311403014060 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 311403014061 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 311403014062 trimer interface [polypeptide binding]; other site 311403014063 active site 311403014064 UDP-GlcNAc binding site [chemical binding]; other site 311403014065 lipid binding site [chemical binding]; lipid-binding site 311403014066 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 311403014067 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 311403014068 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 311403014069 active site 311403014070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494 311403014071 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 311403014072 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 311403014073 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 311403014074 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 311403014075 dimer interface [polypeptide binding]; other site 311403014076 active site 311403014077 citrylCoA binding site [chemical binding]; other site 311403014078 NADH binding [chemical binding]; other site 311403014079 cationic pore residues; other site 311403014080 oxalacetate/citrate binding site [chemical binding]; other site 311403014081 coenzyme A binding site [chemical binding]; other site 311403014082 catalytic triad [active] 311403014083 LexA repressor; Validated; Region: PRK00215 311403014084 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 311403014085 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 311403014086 Catalytic site [active] 311403014087 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 311403014088 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 311403014089 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 311403014090 enolase; Provisional; Region: eno; PRK00077 311403014091 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 311403014092 dimer interface [polypeptide binding]; other site 311403014093 metal binding site [ion binding]; metal-binding site 311403014094 substrate binding pocket [chemical binding]; other site 311403014095 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 311403014096 Septum formation initiator; Region: DivIC; pfam04977 311403014097 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 311403014098 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 311403014099 tetramer interface [polypeptide binding]; other site 311403014100 TPP-binding site [chemical binding]; other site 311403014101 heterodimer interface [polypeptide binding]; other site 311403014102 phosphorylation loop region [posttranslational modification] 311403014103 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 311403014104 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 311403014105 E3 interaction surface; other site 311403014106 lipoyl attachment site [posttranslational modification]; other site 311403014107 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 311403014108 alpha subunit interface [polypeptide binding]; other site 311403014109 TPP binding site [chemical binding]; other site 311403014110 heterodimer interface [polypeptide binding]; other site 311403014111 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 311403014112 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 311403014113 E3 interaction surface; other site 311403014114 lipoyl attachment site [posttranslational modification]; other site 311403014115 e3 binding domain; Region: E3_binding; pfam02817 311403014116 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 311403014117 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 311403014118 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 311403014119 active site 311403014120 catalytic triad [active] 311403014121 oxyanion hole [active] 311403014122 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 311403014123 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 311403014124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403014125 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 311403014126 Predicted membrane protein [Function unknown]; Region: COG2261 311403014127 lipoyl synthase; Provisional; Region: PRK05481 311403014128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403014129 FeS/SAM binding site; other site 311403014130 topology modulation protein; Reviewed; Region: PRK08118 311403014131 AAA domain; Region: AAA_17; pfam13207 311403014132 topology modulation protein; Reviewed; Region: PRK08118 311403014133 AAA domain; Region: AAA_17; pfam13207 311403014134 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 311403014135 putative coenzyme Q binding site [chemical binding]; other site 311403014136 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 311403014137 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 311403014138 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 311403014139 substrate binding site; other site 311403014140 dimer interface; other site 311403014141 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 311403014142 homotrimer interaction site [polypeptide binding]; other site 311403014143 zinc binding site [ion binding]; other site 311403014144 CDP-binding sites; other site 311403014145 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 311403014146 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 311403014147 FMN binding site [chemical binding]; other site 311403014148 active site 311403014149 catalytic residues [active] 311403014150 substrate binding site [chemical binding]; other site 311403014151 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 311403014152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403014153 dimer interface [polypeptide binding]; other site 311403014154 phosphorylation site [posttranslational modification] 311403014155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403014156 ATP binding site [chemical binding]; other site 311403014157 Mg2+ binding site [ion binding]; other site 311403014158 G-X-G motif; other site 311403014159 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 311403014160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403014161 active site 311403014162 phosphorylation site [posttranslational modification] 311403014163 intermolecular recognition site; other site 311403014164 dimerization interface [polypeptide binding]; other site 311403014165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403014166 Walker A motif; other site 311403014167 ATP binding site [chemical binding]; other site 311403014168 Walker B motif; other site 311403014169 arginine finger; other site 311403014170 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 311403014171 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 311403014172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403014173 dimerization interface [polypeptide binding]; other site 311403014174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403014175 putative active site [active] 311403014176 heme pocket [chemical binding]; other site 311403014177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403014178 dimer interface [polypeptide binding]; other site 311403014179 phosphorylation site [posttranslational modification] 311403014180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403014181 ATP binding site [chemical binding]; other site 311403014182 Mg2+ binding site [ion binding]; other site 311403014183 G-X-G motif; other site 311403014184 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 311403014185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403014186 active site 311403014187 phosphorylation site [posttranslational modification] 311403014188 intermolecular recognition site; other site 311403014189 dimerization interface [polypeptide binding]; other site 311403014190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403014191 Walker A motif; other site 311403014192 ATP binding site [chemical binding]; other site 311403014193 Walker B motif; other site 311403014194 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403014195 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 311403014196 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 311403014197 homodimer interface [polypeptide binding]; other site 311403014198 substrate-cofactor binding pocket; other site 311403014199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403014200 catalytic residue [active] 311403014201 bacterial Hfq-like; Region: Hfq; cd01716 311403014202 hexamer interface [polypeptide binding]; other site 311403014203 Sm1 motif; other site 311403014204 RNA binding site [nucleotide binding]; other site 311403014205 Sm2 motif; other site 311403014206 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 311403014207 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 311403014208 HflX GTPase family; Region: HflX; cd01878 311403014209 G1 box; other site 311403014210 GTP/Mg2+ binding site [chemical binding]; other site 311403014211 Switch I region; other site 311403014212 G2 box; other site 311403014213 G3 box; other site 311403014214 Switch II region; other site 311403014215 G4 box; other site 311403014216 G5 box; other site 311403014217 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 311403014218 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 311403014219 homodimer interface [polypeptide binding]; other site 311403014220 metal binding site [ion binding]; metal-binding site 311403014221 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 311403014222 homodimer interface [polypeptide binding]; other site 311403014223 active site 311403014224 putative chemical substrate binding site [chemical binding]; other site 311403014225 metal binding site [ion binding]; metal-binding site 311403014226 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 311403014227 nucleoside/Zn binding site; other site 311403014228 dimer interface [polypeptide binding]; other site 311403014229 catalytic motif [active] 311403014230 siroheme synthase; Provisional; Region: cysG; PRK10637 311403014231 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 311403014232 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 311403014233 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 311403014234 active site 311403014235 SAM binding site [chemical binding]; other site 311403014236 homodimer interface [polypeptide binding]; other site 311403014237 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 311403014238 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 311403014239 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 311403014240 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 311403014241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749 311403014242 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 311403014243 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 311403014244 FAD binding pocket [chemical binding]; other site 311403014245 FAD binding motif [chemical binding]; other site 311403014246 phosphate binding motif [ion binding]; other site 311403014247 beta-alpha-beta structure motif; other site 311403014248 NAD binding pocket [chemical binding]; other site 311403014249 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403014250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403014251 DNA-binding site [nucleotide binding]; DNA binding site 311403014252 FCD domain; Region: FCD; pfam07729 311403014253 Predicted membrane protein [Function unknown]; Region: COG2261 311403014254 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 311403014255 Phage Terminase; Region: Terminase_1; pfam03354 311403014256 Phage-related protein [Function unknown]; Region: COG4695; cl01923 311403014257 Phage portal protein; Region: Phage_portal; pfam04860 311403014258 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 311403014259 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 311403014260 Phage capsid family; Region: Phage_capsid; pfam05065 311403014261 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 311403014262 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 311403014263 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 311403014264 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 311403014265 tape measure domain; Region: tape_meas_nterm; TIGR02675 311403014266 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 311403014267 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 311403014268 active site 311403014269 catalytic triad [active] 311403014270 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 311403014271 Helix-turn-helix domain; Region: HTH_17; pfam12728 311403014272 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 311403014273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403014274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403014275 non-specific DNA binding site [nucleotide binding]; other site 311403014276 salt bridge; other site 311403014277 sequence-specific DNA binding site [nucleotide binding]; other site 311403014278 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 311403014279 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403014280 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 311403014281 active site 311403014282 Int/Topo IB signature motif; other site 311403014283 DNA binding site [nucleotide binding] 311403014284 Protein of unknown function (DUF982); Region: DUF982; pfam06169 311403014285 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 311403014286 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 311403014287 Predicted permeases [General function prediction only]; Region: COG0679 311403014288 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 311403014289 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403014290 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 311403014291 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 311403014292 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 311403014293 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 311403014294 NADP binding site [chemical binding]; other site 311403014295 dimer interface [polypeptide binding]; other site 311403014296 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 311403014297 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403014298 Walker A/P-loop; other site 311403014299 ATP binding site [chemical binding]; other site 311403014300 Q-loop/lid; other site 311403014301 ABC transporter signature motif; other site 311403014302 Walker B; other site 311403014303 D-loop; other site 311403014304 H-loop/switch region; other site 311403014305 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403014306 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403014307 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403014308 TM-ABC transporter signature motif; other site 311403014309 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403014310 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 311403014311 TM-ABC transporter signature motif; other site 311403014312 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 311403014313 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 311403014314 putative ligand binding site [chemical binding]; other site 311403014315 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403014316 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 311403014317 putative ligand binding site [chemical binding]; other site 311403014318 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403014319 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403014320 Walker A/P-loop; other site 311403014321 ATP binding site [chemical binding]; other site 311403014322 Q-loop/lid; other site 311403014323 ABC transporter signature motif; other site 311403014324 Walker B; other site 311403014325 D-loop; other site 311403014326 H-loop/switch region; other site 311403014327 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403014328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403014329 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403014330 TM-ABC transporter signature motif; other site 311403014331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403014332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403014333 TM-ABC transporter signature motif; other site 311403014334 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403014335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403014336 DNA-binding site [nucleotide binding]; DNA binding site 311403014337 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 311403014338 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 311403014339 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 311403014340 Substrate binding site; other site 311403014341 Mg++ binding site; other site 311403014342 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 311403014343 active site 311403014344 substrate binding site [chemical binding]; other site 311403014345 CoA binding site [chemical binding]; other site 311403014346 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 311403014347 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 311403014348 glutaminase active site [active] 311403014349 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 311403014350 dimer interface [polypeptide binding]; other site 311403014351 active site 311403014352 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 311403014353 dimer interface [polypeptide binding]; other site 311403014354 active site 311403014355 Uncharacterized conserved protein [Function unknown]; Region: COG2928 311403014356 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 311403014357 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 311403014358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 311403014359 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 311403014360 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 311403014361 generic binding surface II; other site 311403014362 ssDNA binding site; other site 311403014363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403014364 ATP binding site [chemical binding]; other site 311403014365 putative Mg++ binding site [ion binding]; other site 311403014366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403014367 nucleotide binding region [chemical binding]; other site 311403014368 ATP-binding site [chemical binding]; other site 311403014369 Uncharacterized conserved protein [Function unknown]; Region: COG2938 311403014370 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 311403014371 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 311403014372 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403014373 ATP binding site [chemical binding]; other site 311403014374 putative Mg++ binding site [ion binding]; other site 311403014375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403014376 nucleotide binding region [chemical binding]; other site 311403014377 ATP-binding site [chemical binding]; other site 311403014378 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 311403014379 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403014380 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403014381 Coenzyme A binding pocket [chemical binding]; other site 311403014382 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 311403014383 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 311403014384 catalytic residues [active] 311403014385 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 311403014386 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 311403014387 Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342 311403014388 Uncharacterized conserved protein [Function unknown]; Region: COG3785 311403014389 glutamine synthetase; Provisional; Region: glnA; PRK09469 311403014390 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 311403014391 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 311403014392 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 311403014393 Nitrogen regulatory protein P-II; Region: P-II; smart00938 311403014394 putative carbohydrate kinase; Provisional; Region: PRK10565 311403014395 Uncharacterized conserved protein [Function unknown]; Region: COG0062 311403014396 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 311403014397 putative substrate binding site [chemical binding]; other site 311403014398 putative ATP binding site [chemical binding]; other site 311403014399 Protein of unknown function DUF72; Region: DUF72; pfam01904 311403014400 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 311403014401 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 311403014402 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 311403014403 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 311403014404 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 311403014405 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 311403014406 dimer interface [polypeptide binding]; other site 311403014407 ssDNA binding site [nucleotide binding]; other site 311403014408 tetramer (dimer of dimers) interface [polypeptide binding]; other site 311403014409 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 311403014410 DNA gyrase subunit A; Validated; Region: PRK05560 311403014411 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 311403014412 CAP-like domain; other site 311403014413 active site 311403014414 primary dimer interface [polypeptide binding]; other site 311403014415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 311403014416 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 311403014417 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 311403014418 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 311403014419 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 311403014420 DoxX-like family; Region: DoxX_2; pfam13564 311403014421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403014422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403014423 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 311403014424 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 311403014425 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 311403014426 active site 311403014427 (T/H)XGH motif; other site 311403014428 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 311403014429 active site 311403014430 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 311403014431 active site 311403014432 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 311403014433 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 311403014434 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 311403014435 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 311403014436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403014437 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403014438 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403014439 active site 311403014440 metal binding site [ion binding]; metal-binding site 311403014441 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 311403014442 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 311403014443 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 311403014444 dimer interface [polypeptide binding]; other site 311403014445 active site 311403014446 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403014447 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403014448 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 311403014449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403014450 Coenzyme A binding pocket [chemical binding]; other site 311403014451 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403014452 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403014453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403014454 Walker A/P-loop; other site 311403014455 ATP binding site [chemical binding]; other site 311403014456 Q-loop/lid; other site 311403014457 ABC transporter signature motif; other site 311403014458 Walker B; other site 311403014459 D-loop; other site 311403014460 H-loop/switch region; other site 311403014461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403014462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403014463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403014464 Walker A/P-loop; other site 311403014465 ATP binding site [chemical binding]; other site 311403014466 Q-loop/lid; other site 311403014467 ABC transporter signature motif; other site 311403014468 Walker B; other site 311403014469 D-loop; other site 311403014470 H-loop/switch region; other site 311403014471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403014472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403014473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403014474 dimerization interface [polypeptide binding]; other site 311403014475 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 311403014476 putative deacylase active site [active] 311403014477 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 311403014478 putative hydrolase; Provisional; Region: PRK02113 311403014479 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 311403014480 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 311403014481 active site 311403014482 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 311403014483 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 311403014484 active site 311403014485 HIGH motif; other site 311403014486 KMSKS motif; other site 311403014487 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 311403014488 tRNA binding surface [nucleotide binding]; other site 311403014489 anticodon binding site; other site 311403014490 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 311403014491 DNA polymerase III subunit delta'; Validated; Region: PRK09112 311403014492 AAA ATPase domain; Region: AAA_16; pfam13191 311403014493 DNA polymerase III subunit delta'; Validated; Region: PRK08485 311403014494 thymidylate kinase; Validated; Region: tmk; PRK00698 311403014495 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 311403014496 TMP-binding site; other site 311403014497 ATP-binding site [chemical binding]; other site 311403014498 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 311403014499 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 311403014500 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 311403014501 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 311403014502 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 311403014503 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 311403014504 active site 311403014505 DNA binding site [nucleotide binding] 311403014506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403014507 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 311403014508 putative substrate translocation pore; other site 311403014509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403014510 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 311403014511 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403014512 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403014513 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403014514 MarR family; Region: MarR; pfam01047 311403014515 SurA N-terminal domain; Region: SurA_N_3; cl07813 311403014516 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 311403014517 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 311403014518 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 311403014519 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 311403014520 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 311403014521 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 311403014522 active site 311403014523 ribulose/triose binding site [chemical binding]; other site 311403014524 phosphate binding site [ion binding]; other site 311403014525 substrate (anthranilate) binding pocket [chemical binding]; other site 311403014526 product (indole) binding pocket [chemical binding]; other site 311403014527 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 311403014528 trimer interface [polypeptide binding]; other site 311403014529 dimer interface [polypeptide binding]; other site 311403014530 putative active site [active] 311403014531 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 311403014532 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 311403014533 dimer interface [polypeptide binding]; other site 311403014534 putative functional site; other site 311403014535 putative MPT binding site; other site 311403014536 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 311403014537 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 311403014538 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 311403014539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403014540 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 311403014541 dimer interface [polypeptide binding]; other site 311403014542 active site 311403014543 coenzyme A binding site [chemical binding]; other site 311403014544 citrylCoA binding site [chemical binding]; other site 311403014545 Citrate synthase; Region: Citrate_synt; pfam00285 311403014546 oxalacetate/citrate binding site [chemical binding]; other site 311403014547 catalytic triad [active] 311403014548 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 311403014549 dimer interface [polypeptide binding]; other site 311403014550 Citrate synthase; Region: Citrate_synt; pfam00285 311403014551 active site 311403014552 citrylCoA binding site [chemical binding]; other site 311403014553 oxalacetate/citrate binding site [chemical binding]; other site 311403014554 coenzyme A binding site [chemical binding]; other site 311403014555 catalytic triad [active] 311403014556 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403014557 CHASE2 domain; Region: CHASE2; pfam05226 311403014558 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 311403014559 cyclase homology domain; Region: CHD; cd07302 311403014560 nucleotidyl binding site; other site 311403014561 metal binding site [ion binding]; metal-binding site 311403014562 dimer interface [polypeptide binding]; other site 311403014563 FecR protein; Region: FecR; pfam04773 311403014564 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 311403014565 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 311403014566 active site residue [active] 311403014567 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 311403014568 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 311403014569 conserved cys residue [active] 311403014570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403014571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403014572 CTP synthetase; Validated; Region: pyrG; PRK05380 311403014573 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 311403014574 Catalytic site [active] 311403014575 active site 311403014576 UTP binding site [chemical binding]; other site 311403014577 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 311403014578 active site 311403014579 putative oxyanion hole; other site 311403014580 catalytic triad [active] 311403014581 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 311403014582 triosephosphate isomerase; Provisional; Region: PRK14565 311403014583 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 311403014584 dimer interface [polypeptide binding]; other site 311403014585 substrate binding site [chemical binding]; other site 311403014586 catalytic triad [active] 311403014587 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 311403014588 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 311403014589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403014590 Mg2+ binding site [ion binding]; other site 311403014591 G-X-G motif; other site 311403014592 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 311403014593 anchoring element; other site 311403014594 dimer interface [polypeptide binding]; other site 311403014595 ATP binding site [chemical binding]; other site 311403014596 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 311403014597 active site 311403014598 metal binding site [ion binding]; metal-binding site 311403014599 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 311403014600 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 311403014601 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 311403014602 Domain of unknown function DUF20; Region: UPF0118; pfam01594 311403014603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403014604 Coenzyme A binding pocket [chemical binding]; other site 311403014605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330 311403014606 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 311403014607 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 311403014608 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 311403014609 putative FMN binding site [chemical binding]; other site 311403014610 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 311403014611 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 311403014612 putative acyl-acceptor binding pocket; other site 311403014613 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 311403014614 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 311403014615 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 311403014616 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 311403014617 active site 311403014618 dimer interface [polypeptide binding]; other site 311403014619 motif 1; other site 311403014620 motif 2; other site 311403014621 motif 3; other site 311403014622 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 311403014623 anticodon binding site; other site 311403014624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 311403014625 hypothetical protein; Validated; Region: PRK00041 311403014626 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 311403014627 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 311403014628 trimerization site [polypeptide binding]; other site 311403014629 active site 311403014630 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 311403014631 homodecamer interface [polypeptide binding]; other site 311403014632 GTP cyclohydrolase I; Provisional; Region: PLN03044 311403014633 active site 311403014634 putative catalytic site residues [active] 311403014635 zinc binding site [ion binding]; other site 311403014636 GTP-CH-I/GFRP interaction surface; other site 311403014637 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 311403014638 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 311403014639 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 311403014640 nucleophile elbow; other site 311403014641 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 311403014642 FOG: CBS domain [General function prediction only]; Region: COG0517 311403014643 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 311403014644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 311403014645 PAS domain; Region: PAS_5; pfam07310 311403014646 PilZ domain; Region: PilZ; pfam07238 311403014647 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 311403014648 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 311403014649 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 311403014650 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 311403014651 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 311403014652 Sporulation related domain; Region: SPOR; pfam05036 311403014653 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 311403014654 Uncharacterized conserved protein [Function unknown]; Region: COG5458 311403014655 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 311403014656 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 311403014657 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 311403014658 Predicted membrane protein [Function unknown]; Region: COG3821 311403014659 Predicted membrane protein [Function unknown]; Region: COG3503 311403014660 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 311403014661 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 311403014662 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 311403014663 DNA binding residues [nucleotide binding] 311403014664 putative dimer interface [polypeptide binding]; other site 311403014665 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 311403014666 MgtE intracellular N domain; Region: MgtE_N; smart00924 311403014667 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 311403014668 Divalent cation transporter; Region: MgtE; pfam01769 311403014669 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 311403014670 active site 311403014671 catalytic residues [active] 311403014672 metal binding site [ion binding]; metal-binding site 311403014673 lipoate-protein ligase B; Provisional; Region: PRK14341 311403014674 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403014675 non-specific DNA binding site [nucleotide binding]; other site 311403014676 salt bridge; other site 311403014677 sequence-specific DNA binding site [nucleotide binding]; other site 311403014678 EamA-like transporter family; Region: EamA; pfam00892 311403014679 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 311403014680 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 311403014681 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403014682 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 311403014683 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 311403014684 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403014685 carboxyltransferase (CT) interaction site; other site 311403014686 biotinylation site [posttranslational modification]; other site 311403014687 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 311403014688 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 311403014689 substrate binding site [chemical binding]; other site 311403014690 catalytic Zn binding site [ion binding]; other site 311403014691 NAD binding site [chemical binding]; other site 311403014692 structural Zn binding site [ion binding]; other site 311403014693 dimer interface [polypeptide binding]; other site 311403014694 hypothetical protein; Validated; Region: PRK00124 311403014695 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 311403014696 S-formylglutathione hydrolase; Region: PLN02442 311403014697 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 311403014698 Predicted membrane protein [Function unknown]; Region: COG2259 311403014699 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 311403014700 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 311403014701 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 311403014702 Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387 311403014703 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 311403014704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403014705 motif II; other site 311403014706 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 311403014707 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403014708 RNA binding surface [nucleotide binding]; other site 311403014709 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 311403014710 active site 311403014711 Protein of unknown function (DUF461); Region: DUF461; pfam04314 311403014712 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 311403014713 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403014714 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 311403014715 lipoyl attachment site [posttranslational modification]; other site 311403014716 glycine dehydrogenase; Provisional; Region: PRK05367 311403014717 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 311403014718 tetramer interface [polypeptide binding]; other site 311403014719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403014720 catalytic residue [active] 311403014721 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 311403014722 tetramer interface [polypeptide binding]; other site 311403014723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403014724 catalytic residue [active] 311403014725 putative hydrolase; Provisional; Region: PRK11460 311403014726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403014727 non-specific DNA binding site [nucleotide binding]; other site 311403014728 salt bridge; other site 311403014729 sequence-specific DNA binding site [nucleotide binding]; other site 311403014730 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 311403014731 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 311403014732 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 311403014733 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 311403014734 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403014735 catalytic residue [active] 311403014736 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 311403014737 FeS assembly protein SufD; Region: sufD; TIGR01981 311403014738 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 311403014739 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 311403014740 Walker A/P-loop; other site 311403014741 ATP binding site [chemical binding]; other site 311403014742 Q-loop/lid; other site 311403014743 ABC transporter signature motif; other site 311403014744 Walker B; other site 311403014745 D-loop; other site 311403014746 H-loop/switch region; other site 311403014747 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 311403014748 putative ABC transporter; Region: ycf24; CHL00085 311403014749 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 311403014750 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 311403014751 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403014752 catalytic residue [active] 311403014753 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 311403014754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403014755 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403014756 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 311403014757 Caspase domain; Region: Peptidase_C14; pfam00656 311403014758 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 311403014759 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 311403014760 active site 311403014761 HIGH motif; other site 311403014762 dimer interface [polypeptide binding]; other site 311403014763 KMSKS motif; other site 311403014764 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403014765 RNA binding surface [nucleotide binding]; other site 311403014766 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403014767 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 311403014768 Protein of unknown function; Region: DUF3971; pfam13116 311403014769 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 311403014770 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 311403014771 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 311403014772 catalytic triad [active] 311403014773 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 311403014774 dinuclear metal binding motif [ion binding]; other site 311403014775 Synaptobrevin; Region: Synaptobrevin; pfam00957 311403014776 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 311403014777 Peptidase family M23; Region: Peptidase_M23; pfam01551 311403014778 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 311403014779 DEAD-like helicases superfamily; Region: DEXDc; smart00487 311403014780 ATP binding site [chemical binding]; other site 311403014781 Mg++ binding site [ion binding]; other site 311403014782 motif III; other site 311403014783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403014784 nucleotide binding region [chemical binding]; other site 311403014785 ATP-binding site [chemical binding]; other site 311403014786 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 311403014787 nudix motif; other site 311403014788 TfoX N-terminal domain; Region: TfoX_N; pfam04993 311403014789 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 311403014790 putative MPT binding site; other site 311403014791 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 311403014792 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 311403014793 Ligand binding site; other site 311403014794 metal-binding site 311403014795 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 311403014796 XdhC Rossmann domain; Region: XdhC_C; pfam13478 311403014797 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 311403014798 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 311403014799 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 311403014800 metal ion-dependent adhesion site (MIDAS); other site 311403014801 MoxR-like ATPases [General function prediction only]; Region: COG0714 311403014802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403014803 Walker A motif; other site 311403014804 ATP binding site [chemical binding]; other site 311403014805 Walker B motif; other site 311403014806 arginine finger; other site 311403014807 Flavin Reductases; Region: FlaRed; cl00801 311403014808 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 311403014809 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 311403014810 ligand binding site [chemical binding]; other site 311403014811 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 311403014812 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 311403014813 substrate binding site [chemical binding]; other site 311403014814 hexamer interface [polypeptide binding]; other site 311403014815 metal binding site [ion binding]; metal-binding site 311403014816 adenylosuccinate lyase; Provisional; Region: PRK07492 311403014817 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 311403014818 tetramer interface [polypeptide binding]; other site 311403014819 active site 311403014820 Low affinity iron permease; Region: Iron_permease; pfam04120 311403014821 Predicted integral membrane protein [Function unknown]; Region: COG5473 311403014822 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 311403014823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403014824 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 311403014825 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 311403014826 ATP binding site [chemical binding]; other site 311403014827 active site 311403014828 substrate binding site [chemical binding]; other site 311403014829 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 311403014830 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 311403014831 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 311403014832 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 311403014833 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 311403014834 putative active site [active] 311403014835 catalytic triad [active] 311403014836 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 311403014837 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 311403014838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403014839 DNA-binding site [nucleotide binding]; DNA binding site 311403014840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403014841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403014842 homodimer interface [polypeptide binding]; other site 311403014843 catalytic residue [active] 311403014844 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 311403014845 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 311403014846 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 311403014847 dimerization interface [polypeptide binding]; other site 311403014848 ATP binding site [chemical binding]; other site 311403014849 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 311403014850 dimerization interface [polypeptide binding]; other site 311403014851 ATP binding site [chemical binding]; other site 311403014852 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 311403014853 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 311403014854 putative GSH binding site [chemical binding]; other site 311403014855 catalytic residues [active] 311403014856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403014857 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 311403014858 putative substrate translocation pore; other site 311403014859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403014860 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403014861 putative substrate translocation pore; other site 311403014862 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403014863 cyclase homology domain; Region: CHD; cd07302 311403014864 nucleotidyl binding site; other site 311403014865 metal binding site [ion binding]; metal-binding site 311403014866 dimer interface [polypeptide binding]; other site 311403014867 2TM domain; Region: 2TM; pfam13239 311403014868 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 311403014869 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403014870 active site 311403014871 putative lithium-binding site [ion binding]; other site 311403014872 substrate binding site [chemical binding]; other site 311403014873 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403014874 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 311403014875 active site 311403014876 putative lithium-binding site [ion binding]; other site 311403014877 substrate binding site [chemical binding]; other site 311403014878 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 311403014879 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 311403014880 Ligand Binding Site [chemical binding]; other site 311403014881 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 311403014882 glutaminase; Provisional; Region: PRK00971 311403014883 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 311403014884 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 311403014885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403014886 RNA binding surface [nucleotide binding]; other site 311403014887 Domain of unknown function DUF87; Region: DUF87; pfam01935 311403014888 HerA helicase [Replication, recombination, and repair]; Region: COG0433 311403014889 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 311403014890 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 311403014891 phosphate binding site [ion binding]; other site 311403014892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403014893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403014894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403014895 Coenzyme A binding pocket [chemical binding]; other site 311403014896 glutamate racemase; Provisional; Region: PRK00865 311403014897 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 311403014898 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 311403014899 isocitrate dehydrogenase; Validated; Region: PRK08299 311403014900 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403014901 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 311403014902 putative C-terminal domain interface [polypeptide binding]; other site 311403014903 putative GSH binding site (G-site) [chemical binding]; other site 311403014904 putative dimer interface [polypeptide binding]; other site 311403014905 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 311403014906 dimer interface [polypeptide binding]; other site 311403014907 N-terminal domain interface [polypeptide binding]; other site 311403014908 putative substrate binding pocket (H-site) [chemical binding]; other site 311403014909 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403014910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403014911 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 311403014912 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 311403014913 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 311403014914 motif 1; other site 311403014915 active site 311403014916 motif 2; other site 311403014917 motif 3; other site 311403014918 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 311403014919 recombinase A; Provisional; Region: recA; PRK09354 311403014920 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 311403014921 hexamer interface [polypeptide binding]; other site 311403014922 Walker A motif; other site 311403014923 ATP binding site [chemical binding]; other site 311403014924 Walker B motif; other site 311403014925 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403014926 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 311403014927 substrate binding site [chemical binding]; other site 311403014928 ATP binding site [chemical binding]; other site 311403014929 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 311403014930 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 311403014931 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 311403014932 active site 311403014933 HIGH motif; other site 311403014934 dimer interface [polypeptide binding]; other site 311403014935 KMSKS motif; other site 311403014936 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403014937 PAS domain; Region: PAS_9; pfam13426 311403014938 putative active site [active] 311403014939 heme pocket [chemical binding]; other site 311403014940 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 311403014941 PAS domain; Region: PAS; smart00091 311403014942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403014943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403014944 dimer interface [polypeptide binding]; other site 311403014945 phosphorylation site [posttranslational modification] 311403014946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403014947 ATP binding site [chemical binding]; other site 311403014948 Mg2+ binding site [ion binding]; other site 311403014949 G-X-G motif; other site 311403014950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403014951 Response regulator receiver domain; Region: Response_reg; pfam00072 311403014952 active site 311403014953 phosphorylation site [posttranslational modification] 311403014954 intermolecular recognition site; other site 311403014955 dimerization interface [polypeptide binding]; other site 311403014956 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 311403014957 conserved cys residue [active] 311403014958 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 311403014959 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403014960 catalytic core [active] 311403014961 YcjX-like family, DUF463; Region: DUF463; pfam04317 311403014962 Predicted membrane protein [Function unknown]; Region: COG3768 311403014963 Domain of unknown function (DUF697); Region: DUF697; cl12064 311403014964 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 311403014965 catalytic center binding site [active] 311403014966 ATP binding site [chemical binding]; other site 311403014967 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 311403014968 homooctamer interface [polypeptide binding]; other site 311403014969 active site 311403014970 dihydropteroate synthase; Region: DHPS; TIGR01496 311403014971 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 311403014972 substrate binding pocket [chemical binding]; other site 311403014973 dimer interface [polypeptide binding]; other site 311403014974 inhibitor binding site; inhibition site 311403014975 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 311403014976 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 311403014977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403014978 catalytic loop [active] 311403014979 iron binding site [ion binding]; other site 311403014980 Hpt domain; Region: Hpt; pfam01627 311403014981 putative binding surface; other site 311403014982 active site 311403014983 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 311403014984 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403014985 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 311403014986 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 311403014987 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 311403014988 inhibitor binding site; inhibition site 311403014989 active site 311403014990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403014991 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403014992 active site 311403014993 catalytic tetrad [active] 311403014994 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403014995 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403014996 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403014997 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 311403014998 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 311403014999 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 311403015000 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403015001 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403015002 Walker A/P-loop; other site 311403015003 ATP binding site [chemical binding]; other site 311403015004 Q-loop/lid; other site 311403015005 ABC transporter signature motif; other site 311403015006 Walker B; other site 311403015007 D-loop; other site 311403015008 H-loop/switch region; other site 311403015009 TOBE domain; Region: TOBE_2; pfam08402 311403015010 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403015011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015012 dimer interface [polypeptide binding]; other site 311403015013 conserved gate region; other site 311403015014 putative PBP binding loops; other site 311403015015 ABC-ATPase subunit interface; other site 311403015016 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 311403015017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015018 dimer interface [polypeptide binding]; other site 311403015019 conserved gate region; other site 311403015020 putative PBP binding loops; other site 311403015021 ABC-ATPase subunit interface; other site 311403015022 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403015023 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403015024 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403015025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403015026 DNA binding site [nucleotide binding] 311403015027 domain linker motif; other site 311403015028 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 311403015029 ligand binding site [chemical binding]; other site 311403015030 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 311403015031 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 311403015032 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 311403015033 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 311403015034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403015035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403015036 Coenzyme A binding pocket [chemical binding]; other site 311403015037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 311403015038 Protein of unknown function (DUF330); Region: DUF330; cl01135 311403015039 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 311403015040 mce related protein; Region: MCE; pfam02470 311403015041 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 311403015042 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 311403015043 Walker A/P-loop; other site 311403015044 ATP binding site [chemical binding]; other site 311403015045 Q-loop/lid; other site 311403015046 ABC transporter signature motif; other site 311403015047 Walker B; other site 311403015048 D-loop; other site 311403015049 H-loop/switch region; other site 311403015050 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 311403015051 Permease; Region: Permease; pfam02405 311403015052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403015053 putative substrate translocation pore; other site 311403015054 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 311403015055 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403015056 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 311403015057 putative active site [active] 311403015058 putative metal binding site [ion binding]; other site 311403015059 malic enzyme; Reviewed; Region: PRK12862 311403015060 Malic enzyme, N-terminal domain; Region: malic; pfam00390 311403015061 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 311403015062 putative NAD(P) binding site [chemical binding]; other site 311403015063 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 311403015064 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 311403015065 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 311403015066 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 311403015067 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 311403015068 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 311403015069 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 311403015070 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 311403015071 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 311403015072 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 311403015073 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 311403015074 NAD synthetase; Provisional; Region: PRK13981 311403015075 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 311403015076 multimer interface [polypeptide binding]; other site 311403015077 active site 311403015078 catalytic triad [active] 311403015079 protein interface 1 [polypeptide binding]; other site 311403015080 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 311403015081 homodimer interface [polypeptide binding]; other site 311403015082 NAD binding pocket [chemical binding]; other site 311403015083 ATP binding pocket [chemical binding]; other site 311403015084 Mg binding site [ion binding]; other site 311403015085 active-site loop [active] 311403015086 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 311403015087 Sulfatase; Region: Sulfatase; pfam00884 311403015088 Predicted membrane protein [Function unknown]; Region: COG4420 311403015089 Predicted transcriptional regulator [Transcription]; Region: COG3905 311403015090 Uncharacterized conserved protein [Function unknown]; Region: COG3791 311403015091 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 311403015092 glutathione reductase; Validated; Region: PRK06116 311403015093 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403015094 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 311403015095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 311403015096 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 311403015097 tetramer (dimer of dimers) interface [polypeptide binding]; other site 311403015098 active site 311403015099 dimer interface [polypeptide binding]; other site 311403015100 phosphoglycolate phosphatase; Provisional; Region: PRK13222 311403015101 Acid Phosphatase; Region: Acid_PPase; cl17256 311403015102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403015103 motif II; other site 311403015104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 311403015105 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403015106 fumarate hydratase; Reviewed; Region: fumC; PRK00485 311403015107 Class II fumarases; Region: Fumarase_classII; cd01362 311403015108 active site 311403015109 tetramer interface [polypeptide binding]; other site 311403015110 fumarate hydratase; Provisional; Region: PRK15389 311403015111 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 311403015112 Fumarase C-terminus; Region: Fumerase_C; pfam05683 311403015113 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403015114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403015115 metal binding site [ion binding]; metal-binding site 311403015116 active site 311403015117 I-site; other site 311403015118 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 311403015119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403015120 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 311403015121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403015122 MarR family; Region: MarR; pfam01047 311403015123 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 311403015124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 311403015125 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 311403015126 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403015127 FeS/SAM binding site; other site 311403015128 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 311403015129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403015130 S-adenosylmethionine binding site [chemical binding]; other site 311403015131 HAMP domain; Region: HAMP; pfam00672 311403015132 dimerization interface [polypeptide binding]; other site 311403015133 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403015134 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403015135 dimer interface [polypeptide binding]; other site 311403015136 putative CheW interface [polypeptide binding]; other site 311403015137 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403015138 EamA-like transporter family; Region: EamA; pfam00892 311403015139 EamA-like transporter family; Region: EamA; cl17759 311403015140 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 311403015141 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 311403015142 GTP binding site; other site 311403015143 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 311403015144 Walker A motif; other site 311403015145 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 311403015146 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 311403015147 ligand binding site [chemical binding]; other site 311403015148 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403015149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403015150 substrate binding pocket [chemical binding]; other site 311403015151 membrane-bound complex binding site; other site 311403015152 hinge residues; other site 311403015153 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403015154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015155 dimer interface [polypeptide binding]; other site 311403015156 conserved gate region; other site 311403015157 putative PBP binding loops; other site 311403015158 ABC-ATPase subunit interface; other site 311403015159 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403015160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015161 dimer interface [polypeptide binding]; other site 311403015162 conserved gate region; other site 311403015163 putative PBP binding loops; other site 311403015164 ABC-ATPase subunit interface; other site 311403015165 Usg-like family; Region: Usg; cl11567 311403015166 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 311403015167 Tetratricopeptide repeat; Region: TPR_1; pfam00515 311403015168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403015169 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403015170 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 311403015171 C-terminal domain interface [polypeptide binding]; other site 311403015172 GSH binding site (G-site) [chemical binding]; other site 311403015173 dimer interface [polypeptide binding]; other site 311403015174 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 311403015175 N-terminal domain interface [polypeptide binding]; other site 311403015176 dimer interface [polypeptide binding]; other site 311403015177 substrate binding pocket (H-site) [chemical binding]; other site 311403015178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403015179 dimerization interface [polypeptide binding]; other site 311403015180 putative DNA binding site [nucleotide binding]; other site 311403015181 putative Zn2+ binding site [ion binding]; other site 311403015182 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 311403015183 putative hydrophobic ligand binding site [chemical binding]; other site 311403015184 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403015185 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403015186 Walker A/P-loop; other site 311403015187 ATP binding site [chemical binding]; other site 311403015188 Q-loop/lid; other site 311403015189 ABC transporter signature motif; other site 311403015190 Walker B; other site 311403015191 D-loop; other site 311403015192 H-loop/switch region; other site 311403015193 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403015194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015195 dimer interface [polypeptide binding]; other site 311403015196 conserved gate region; other site 311403015197 putative PBP binding loops; other site 311403015198 ABC-ATPase subunit interface; other site 311403015199 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403015200 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 311403015201 active site 311403015202 dimer interface [polypeptide binding]; other site 311403015203 non-prolyl cis peptide bond; other site 311403015204 insertion regions; other site 311403015205 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 311403015206 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403015207 membrane-bound complex binding site; other site 311403015208 hinge residues; other site 311403015209 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 311403015210 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 311403015211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403015212 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403015213 putative DNA binding site [nucleotide binding]; other site 311403015214 putative Zn2+ binding site [ion binding]; other site 311403015215 AsnC family; Region: AsnC_trans_reg; pfam01037 311403015216 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 311403015217 putative uracil binding site [chemical binding]; other site 311403015218 putative active site [active] 311403015219 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 311403015220 Catalytic site; other site 311403015221 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 311403015222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403015223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403015224 dimer interface [polypeptide binding]; other site 311403015225 phosphorylation site [posttranslational modification] 311403015226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403015227 ATP binding site [chemical binding]; other site 311403015228 Mg2+ binding site [ion binding]; other site 311403015229 G-X-G motif; other site 311403015230 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 311403015231 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 311403015232 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 311403015233 putative dimer interface [polypeptide binding]; other site 311403015234 active site pocket [active] 311403015235 putative cataytic base [active] 311403015236 cobalamin synthase; Reviewed; Region: cobS; PRK00235 311403015237 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 311403015238 Predicted aspartyl protease [General function prediction only]; Region: COG3577 311403015239 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 311403015240 catalytic motif [active] 311403015241 Catalytic residue [active] 311403015242 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 311403015243 EamA-like transporter family; Region: EamA; pfam00892 311403015244 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 311403015245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403015246 Coenzyme A binding pocket [chemical binding]; other site 311403015247 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 311403015248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 311403015249 ABC-2 type transporter; Region: ABC2_membrane; cl17235 311403015250 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 311403015251 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 311403015252 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 311403015253 Walker A/P-loop; other site 311403015254 ATP binding site [chemical binding]; other site 311403015255 Q-loop/lid; other site 311403015256 ABC transporter signature motif; other site 311403015257 Walker B; other site 311403015258 D-loop; other site 311403015259 H-loop/switch region; other site 311403015260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921 311403015261 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 311403015262 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 311403015263 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403015264 Sel1-like repeats; Region: SEL1; smart00671 311403015265 Sel1-like repeats; Region: SEL1; smart00671 311403015266 Sel1-like repeats; Region: SEL1; smart00671 311403015267 Sel1-like repeats; Region: SEL1; smart00671 311403015268 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403015269 Sel1-like repeats; Region: SEL1; smart00671 311403015270 Sel1-like repeats; Region: SEL1; smart00671 311403015271 Sel1-like repeats; Region: SEL1; smart00671 311403015272 Sel1-like repeats; Region: SEL1; smart00671 311403015273 Sel1-like repeats; Region: SEL1; smart00671 311403015274 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403015275 Sel1-like repeats; Region: SEL1; smart00671 311403015276 Sel1-like repeats; Region: SEL1; smart00671 311403015277 Sel1-like repeats; Region: SEL1; smart00671 311403015278 Sel1-like repeats; Region: SEL1; smart00671 311403015279 Sel1-like repeats; Region: SEL1; smart00671 311403015280 Sel1-like repeats; Region: SEL1; smart00671 311403015281 Sel1-like repeats; Region: SEL1; smart00671 311403015282 Sel1-like repeats; Region: SEL1; smart00671 311403015283 Sel1-like repeats; Region: SEL1; smart00671 311403015284 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403015285 Sel1-like repeats; Region: SEL1; smart00671 311403015286 Sel1-like repeats; Region: SEL1; smart00671 311403015287 putative sialic acid transporter; Region: 2A0112; TIGR00891 311403015288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403015289 putative substrate translocation pore; other site 311403015290 excinuclease ABC subunit B; Provisional; Region: PRK05298 311403015291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403015292 ATP binding site [chemical binding]; other site 311403015293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403015294 nucleotide binding region [chemical binding]; other site 311403015295 ATP-binding site [chemical binding]; other site 311403015296 Ultra-violet resistance protein B; Region: UvrB; pfam12344 311403015297 UvrB/uvrC motif; Region: UVR; pfam02151 311403015298 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 311403015299 putative hydrophobic ligand binding site [chemical binding]; other site 311403015300 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403015301 cyclase homology domain; Region: CHD; cd07302 311403015302 nucleotidyl binding site; other site 311403015303 metal binding site [ion binding]; metal-binding site 311403015304 dimer interface [polypeptide binding]; other site 311403015305 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403015306 DNA-binding site [nucleotide binding]; DNA binding site 311403015307 RNA-binding motif; other site 311403015308 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 311403015309 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 311403015310 FMN binding site [chemical binding]; other site 311403015311 active site 311403015312 catalytic residues [active] 311403015313 substrate binding site [chemical binding]; other site 311403015314 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 311403015315 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403015316 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 311403015317 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 311403015318 trimer interface [polypeptide binding]; other site 311403015319 putative metal binding site [ion binding]; other site 311403015320 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 311403015321 metal binding site 2 [ion binding]; metal-binding site 311403015322 putative DNA binding helix; other site 311403015323 metal binding site 1 [ion binding]; metal-binding site 311403015324 dimer interface [polypeptide binding]; other site 311403015325 structural Zn2+ binding site [ion binding]; other site 311403015326 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 311403015327 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403015328 ABC-ATPase subunit interface; other site 311403015329 dimer interface [polypeptide binding]; other site 311403015330 putative PBP binding regions; other site 311403015331 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 311403015332 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 311403015333 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 311403015334 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 311403015335 metal binding site [ion binding]; metal-binding site 311403015336 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 311403015337 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 311403015338 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 311403015339 PAS fold; Region: PAS_4; pfam08448 311403015340 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 311403015341 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 311403015342 putative acyl-acceptor binding pocket; other site 311403015343 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 311403015344 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266 311403015345 putative NAD(P) binding site [chemical binding]; other site 311403015346 structural Zn binding site [ion binding]; other site 311403015347 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 311403015348 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 311403015349 dimer interface [polypeptide binding]; other site 311403015350 active site 311403015351 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 311403015352 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 311403015353 active site 311403015354 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 311403015355 active site 2 [active] 311403015356 active site 1 [active] 311403015357 acyl carrier protein; Provisional; Region: PRK06508 311403015358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403015359 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403015360 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 311403015361 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 311403015362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403015363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403015364 homodimer interface [polypeptide binding]; other site 311403015365 catalytic residue [active] 311403015366 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 311403015367 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 311403015368 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 311403015369 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 311403015370 active site 311403015371 SAM binding site [chemical binding]; other site 311403015372 homodimer interface [polypeptide binding]; other site 311403015373 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 311403015374 active site 311403015375 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 311403015376 hypothetical protein; Provisional; Region: PRK10621 311403015377 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 311403015378 SnoaL-like domain; Region: SnoaL_2; pfam12680 311403015379 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403015380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403015381 non-specific DNA binding site [nucleotide binding]; other site 311403015382 salt bridge; other site 311403015383 sequence-specific DNA binding site [nucleotide binding]; other site 311403015384 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 311403015385 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 311403015386 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 311403015387 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 311403015388 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 311403015389 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 311403015390 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 311403015391 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 311403015392 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 311403015393 homotrimer interface [polypeptide binding]; other site 311403015394 Walker A motif; other site 311403015395 GTP binding site [chemical binding]; other site 311403015396 Walker B motif; other site 311403015397 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 311403015398 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 311403015399 Cl- selectivity filter; other site 311403015400 Cl- binding residues [ion binding]; other site 311403015401 pore gating glutamate residue; other site 311403015402 dimer interface [polypeptide binding]; other site 311403015403 FOG: CBS domain [General function prediction only]; Region: COG0517 311403015404 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 311403015405 cobyric acid synthase; Provisional; Region: PRK00784 311403015406 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 311403015407 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 311403015408 catalytic triad [active] 311403015409 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 311403015410 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 311403015411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015412 dimer interface [polypeptide binding]; other site 311403015413 conserved gate region; other site 311403015414 ABC-ATPase subunit interface; other site 311403015415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403015416 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 311403015417 Walker A/P-loop; other site 311403015418 ATP binding site [chemical binding]; other site 311403015419 Q-loop/lid; other site 311403015420 ABC transporter signature motif; other site 311403015421 Walker B; other site 311403015422 D-loop; other site 311403015423 H-loop/switch region; other site 311403015424 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 311403015425 methionine synthase I; Validated; Region: PRK07534 311403015426 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 311403015427 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 311403015428 Predicted periplasmic protein [Function unknown]; Region: COG3698 311403015429 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 311403015430 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 311403015431 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 311403015432 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 311403015433 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 311403015434 B12 binding site [chemical binding]; other site 311403015435 cobalt ligand [ion binding]; other site 311403015436 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 311403015437 Virulence factor; Region: Virulence_fact; pfam13769 311403015438 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 311403015439 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 311403015440 FAD binding site [chemical binding]; other site 311403015441 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 311403015442 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 311403015443 substrate binding pocket [chemical binding]; other site 311403015444 dimer interface [polypeptide binding]; other site 311403015445 inhibitor binding site; inhibition site 311403015446 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 311403015447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403015448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403015449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403015450 dimerization interface [polypeptide binding]; other site 311403015451 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 311403015452 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 311403015453 conserved cys residue [active] 311403015454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403015455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403015456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403015457 active site 311403015458 phosphorylation site [posttranslational modification] 311403015459 intermolecular recognition site; other site 311403015460 dimerization interface [polypeptide binding]; other site 311403015461 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 311403015462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403015463 active site 311403015464 phosphorylation site [posttranslational modification] 311403015465 intermolecular recognition site; other site 311403015466 dimerization interface [polypeptide binding]; other site 311403015467 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403015468 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403015469 metal binding site [ion binding]; metal-binding site 311403015470 active site 311403015471 I-site; other site 311403015472 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 311403015473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 311403015474 active site 311403015475 phosphorylation site [posttranslational modification] 311403015476 intermolecular recognition site; other site 311403015477 dimerization interface [polypeptide binding]; other site 311403015478 Response regulator receiver domain; Region: Response_reg; pfam00072 311403015479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403015480 active site 311403015481 phosphorylation site [posttranslational modification] 311403015482 intermolecular recognition site; other site 311403015483 dimerization interface [polypeptide binding]; other site 311403015484 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 311403015485 Mechanosensitive ion channel; Region: MS_channel; pfam00924 311403015486 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 311403015487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 311403015488 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 311403015489 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 311403015490 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403015491 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403015492 active site 311403015493 Predicted transcriptional regulator [Transcription]; Region: COG1959 311403015494 Transcriptional regulator; Region: Rrf2; pfam02082 311403015495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 311403015496 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 311403015497 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 311403015498 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 311403015499 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 311403015500 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403015501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403015502 Walker A/P-loop; other site 311403015503 ATP binding site [chemical binding]; other site 311403015504 Q-loop/lid; other site 311403015505 ABC transporter signature motif; other site 311403015506 Walker B; other site 311403015507 D-loop; other site 311403015508 H-loop/switch region; other site 311403015509 TOBE domain; Region: TOBE_2; pfam08402 311403015510 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 311403015511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015512 dimer interface [polypeptide binding]; other site 311403015513 conserved gate region; other site 311403015514 putative PBP binding loops; other site 311403015515 ABC-ATPase subunit interface; other site 311403015516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015517 dimer interface [polypeptide binding]; other site 311403015518 conserved gate region; other site 311403015519 putative PBP binding loops; other site 311403015520 ABC-ATPase subunit interface; other site 311403015521 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403015522 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403015523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403015524 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403015525 active site 311403015526 catalytic tetrad [active] 311403015527 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 311403015528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403015529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403015530 homodimer interface [polypeptide binding]; other site 311403015531 catalytic residue [active] 311403015532 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 311403015533 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 311403015534 putative active site [active] 311403015535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403015536 S-adenosylmethionine binding site [chemical binding]; other site 311403015537 ketol-acid reductoisomerase; Provisional; Region: PRK05479 311403015538 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 311403015539 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 311403015540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403015541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403015542 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 311403015543 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403015544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403015545 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 311403015546 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 311403015547 putative NAD(P) binding site [chemical binding]; other site 311403015548 putative substrate binding site [chemical binding]; other site 311403015549 catalytic Zn binding site [ion binding]; other site 311403015550 structural Zn binding site [ion binding]; other site 311403015551 dimer interface [polypeptide binding]; other site 311403015552 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 311403015553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403015554 Bacterial PH domain; Region: DUF304; cl01348 311403015555 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403015556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403015557 putative DNA binding site [nucleotide binding]; other site 311403015558 putative Zn2+ binding site [ion binding]; other site 311403015559 AsnC family; Region: AsnC_trans_reg; pfam01037 311403015560 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 311403015561 aspartate racemase; Region: asp_race; TIGR00035 311403015562 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403015563 MarR family; Region: MarR_2; pfam12802 311403015564 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 311403015565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403015566 Coenzyme A binding pocket [chemical binding]; other site 311403015567 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403015568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403015569 Coenzyme A binding pocket [chemical binding]; other site 311403015570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403015571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403015572 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 311403015573 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 311403015574 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403015575 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403015576 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403015577 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 311403015578 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 311403015579 NADP binding site [chemical binding]; other site 311403015580 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 311403015581 active site 311403015582 dimerization interface [polypeptide binding]; other site 311403015583 hydrophilic channel; other site 311403015584 catalytic residues [active] 311403015585 active site lid [active] 311403015586 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 311403015587 AAA domain; Region: AAA_30; pfam13604 311403015588 Family description; Region: UvrD_C_2; pfam13538 311403015589 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 311403015590 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 311403015591 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 311403015592 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 311403015593 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 311403015594 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 311403015595 NADH(P)-binding; Region: NAD_binding_10; pfam13460 311403015596 putative NAD(P) binding site [chemical binding]; other site 311403015597 active site 311403015598 DoxX-like family; Region: DoxX_3; pfam13781 311403015599 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 311403015600 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403015601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403015602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403015603 active site 311403015604 catalytic tetrad [active] 311403015605 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 311403015606 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 311403015607 putative valine binding site [chemical binding]; other site 311403015608 dimer interface [polypeptide binding]; other site 311403015609 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 311403015610 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 311403015611 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403015612 PYR/PP interface [polypeptide binding]; other site 311403015613 dimer interface [polypeptide binding]; other site 311403015614 TPP binding site [chemical binding]; other site 311403015615 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 311403015616 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 311403015617 TPP-binding site [chemical binding]; other site 311403015618 dimer interface [polypeptide binding]; other site 311403015619 HAS barrel domain; Region: HAS-barrel; pfam09378 311403015620 Domain of unknown function DUF87; Region: DUF87; pfam01935 311403015621 AAA-like domain; Region: AAA_10; pfam12846 311403015622 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 311403015623 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 311403015624 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 311403015625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403015626 motif II; other site 311403015627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403015628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403015629 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 311403015630 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 311403015631 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403015632 protein binding site [polypeptide binding]; other site 311403015633 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403015634 protein binding site [polypeptide binding]; other site 311403015635 FtsH protease regulator HflC; Provisional; Region: PRK11029 311403015636 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 311403015637 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 311403015638 HflK protein; Region: hflK; TIGR01933 311403015639 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 311403015640 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 311403015641 folate binding site [chemical binding]; other site 311403015642 NADP+ binding site [chemical binding]; other site 311403015643 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 311403015644 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 311403015645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 311403015646 active site 311403015647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 311403015648 hypothetical protein; Provisional; Region: PRK09262 311403015649 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 311403015650 tetramer interface [polypeptide binding]; other site 311403015651 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 311403015652 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 311403015653 tetramer interface [polypeptide binding]; other site 311403015654 active site 311403015655 metal binding site [ion binding]; metal-binding site 311403015656 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 311403015657 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403015658 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403015659 TM-ABC transporter signature motif; other site 311403015660 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403015661 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403015662 TM-ABC transporter signature motif; other site 311403015663 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403015664 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403015665 Walker A/P-loop; other site 311403015666 ATP binding site [chemical binding]; other site 311403015667 Q-loop/lid; other site 311403015668 ABC transporter signature motif; other site 311403015669 Walker B; other site 311403015670 D-loop; other site 311403015671 H-loop/switch region; other site 311403015672 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403015673 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403015674 Walker A/P-loop; other site 311403015675 ATP binding site [chemical binding]; other site 311403015676 Q-loop/lid; other site 311403015677 ABC transporter signature motif; other site 311403015678 Walker B; other site 311403015679 D-loop; other site 311403015680 H-loop/switch region; other site 311403015681 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403015682 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403015683 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 311403015684 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 311403015685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403015686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403015687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403015688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403015689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403015690 dimerization interface [polypeptide binding]; other site 311403015691 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403015692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403015693 non-specific DNA binding site [nucleotide binding]; other site 311403015694 salt bridge; other site 311403015695 sequence-specific DNA binding site [nucleotide binding]; other site 311403015696 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 311403015697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403015698 Coenzyme A binding pocket [chemical binding]; other site 311403015699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 311403015700 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 311403015701 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 311403015702 thymidylate synthase; Reviewed; Region: thyA; PRK01827 311403015703 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 311403015704 dimerization interface [polypeptide binding]; other site 311403015705 active site 311403015706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814 311403015707 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 311403015708 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 311403015709 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 311403015710 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 311403015711 FAD binding domain; Region: FAD_binding_4; pfam01565 311403015712 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403015713 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403015714 substrate binding pocket [chemical binding]; other site 311403015715 membrane-bound complex binding site; other site 311403015716 hinge residues; other site 311403015717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015718 dimer interface [polypeptide binding]; other site 311403015719 conserved gate region; other site 311403015720 putative PBP binding loops; other site 311403015721 ABC-ATPase subunit interface; other site 311403015722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015723 dimer interface [polypeptide binding]; other site 311403015724 conserved gate region; other site 311403015725 putative PBP binding loops; other site 311403015726 ABC-ATPase subunit interface; other site 311403015727 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403015728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403015729 Walker A/P-loop; other site 311403015730 ATP binding site [chemical binding]; other site 311403015731 Q-loop/lid; other site 311403015732 ABC transporter signature motif; other site 311403015733 Walker B; other site 311403015734 D-loop; other site 311403015735 H-loop/switch region; other site 311403015736 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403015737 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403015738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403015739 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 311403015740 putative outer membrane lipoprotein; Provisional; Region: PRK10510 311403015741 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 311403015742 ligand binding site [chemical binding]; other site 311403015743 flagellin; Reviewed; Region: PRK12687 311403015744 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 311403015745 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 311403015746 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403015747 Protein export membrane protein; Region: SecD_SecF; cl14618 311403015748 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403015749 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403015750 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403015751 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 311403015752 Part of AAA domain; Region: AAA_19; pfam13245 311403015753 Family description; Region: UvrD_C_2; pfam13538 311403015754 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 311403015755 GIY-YIG motif/motif A; other site 311403015756 putative active site [active] 311403015757 putative metal binding site [ion binding]; other site 311403015758 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 311403015759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403015760 putative substrate translocation pore; other site 311403015761 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 311403015762 Isochorismatase family; Region: Isochorismatase; pfam00857 311403015763 catalytic triad [active] 311403015764 metal binding site [ion binding]; metal-binding site 311403015765 conserved cis-peptide bond; other site 311403015766 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 311403015767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403015768 pantoate--beta-alanine ligase; Region: panC; TIGR00018 311403015769 Pantoate-beta-alanine ligase; Region: PanC; cd00560 311403015770 active site 311403015771 ATP-binding site [chemical binding]; other site 311403015772 pantoate-binding site; other site 311403015773 HXXH motif; other site 311403015774 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 311403015775 oligomerization interface [polypeptide binding]; other site 311403015776 active site 311403015777 metal binding site [ion binding]; metal-binding site 311403015778 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 311403015779 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 311403015780 Predicted membrane protein [Function unknown]; Region: COG4541 311403015781 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403015782 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403015783 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 311403015784 active site 311403015785 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 311403015786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403015787 S-adenosylmethionine binding site [chemical binding]; other site 311403015788 FAD binding domain; Region: FAD_binding_3; pfam01494 311403015789 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403015790 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 311403015791 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 311403015792 Cu(I) binding site [ion binding]; other site 311403015793 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 311403015794 putative CheA interaction surface; other site 311403015795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 311403015796 CreA protein; Region: CreA; pfam05981 311403015797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403015798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403015799 Coenzyme A binding pocket [chemical binding]; other site 311403015800 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 311403015801 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 311403015802 nucleotide binding pocket [chemical binding]; other site 311403015803 K-X-D-G motif; other site 311403015804 catalytic site [active] 311403015805 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 311403015806 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 311403015807 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 311403015808 Dimer interface [polypeptide binding]; other site 311403015809 BRCT sequence motif; other site 311403015810 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 311403015811 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 311403015812 Walker A/P-loop; other site 311403015813 ATP binding site [chemical binding]; other site 311403015814 Q-loop/lid; other site 311403015815 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 311403015816 ABC transporter signature motif; other site 311403015817 Walker B; other site 311403015818 D-loop; other site 311403015819 H-loop/switch region; other site 311403015820 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 311403015821 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 311403015822 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 311403015823 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 311403015824 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 311403015825 nucleotide binding site [chemical binding]; other site 311403015826 SulA interaction site; other site 311403015827 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 311403015828 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 311403015829 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403015830 nucleotide binding site [chemical binding]; other site 311403015831 Cell division protein FtsA; Region: FtsA; pfam14450 311403015832 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 311403015833 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 311403015834 Cell division protein FtsQ; Region: FtsQ; pfam03799 311403015835 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 311403015836 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 311403015837 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403015838 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 311403015839 amphipathic channel; other site 311403015840 Asn-Pro-Ala signature motifs; other site 311403015841 metabolite-proton symporter; Region: 2A0106; TIGR00883 311403015842 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 311403015843 FAD binding domain; Region: FAD_binding_4; pfam01565 311403015844 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 311403015845 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 311403015846 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 311403015847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 311403015848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 311403015849 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 311403015850 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 311403015851 homodimer interface [polypeptide binding]; other site 311403015852 active site 311403015853 cell division protein FtsW; Region: ftsW; TIGR02614 311403015854 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 311403015855 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 311403015856 NAD(P) binding pocket [chemical binding]; other site 311403015857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 311403015858 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 311403015859 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 311403015860 Mg++ binding site [ion binding]; other site 311403015861 putative catalytic motif [active] 311403015862 putative substrate binding site [chemical binding]; other site 311403015863 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 311403015864 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 311403015865 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 311403015866 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 311403015867 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 311403015868 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 311403015869 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 311403015870 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 311403015871 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 311403015872 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 311403015873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 311403015874 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 311403015875 MraW methylase family; Region: Methyltransf_5; cl17771 311403015876 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 311403015877 cell division protein MraZ; Reviewed; Region: PRK00326 311403015878 MraZ protein; Region: MraZ; pfam02381 311403015879 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 311403015880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403015881 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 311403015882 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403015883 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403015884 catalytic residue [active] 311403015885 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 311403015886 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 311403015887 amidase catalytic site [active] 311403015888 Zn binding residues [ion binding]; other site 311403015889 substrate binding site [chemical binding]; other site 311403015890 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403015891 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 311403015892 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 311403015893 putative metal binding site [ion binding]; other site 311403015894 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 311403015895 HSP70 interaction site [polypeptide binding]; other site 311403015896 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 311403015897 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 311403015898 active site 311403015899 ADP/pyrophosphate binding site [chemical binding]; other site 311403015900 dimerization interface [polypeptide binding]; other site 311403015901 allosteric effector site; other site 311403015902 fructose-1,6-bisphosphate binding site; other site 311403015903 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403015904 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 311403015905 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403015906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403015907 catalytic residue [active] 311403015908 Beta-lactamase; Region: Beta-lactamase; pfam00144 311403015909 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 311403015910 S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379 311403015911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403015912 S-adenosylmethionine binding site [chemical binding]; other site 311403015913 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 311403015914 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 311403015915 active site 311403015916 lytic murein transglycosylase; Region: MltB_2; TIGR02283 311403015917 murein hydrolase B; Provisional; Region: PRK10760; cl17906 311403015918 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403015919 EamA-like transporter family; Region: EamA; pfam00892 311403015920 EamA-like transporter family; Region: EamA; pfam00892 311403015921 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 311403015922 FAD binding site [chemical binding]; other site 311403015923 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403015924 putative DNA binding site [nucleotide binding]; other site 311403015925 dimerization interface [polypeptide binding]; other site 311403015926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403015927 S-adenosylmethionine binding site [chemical binding]; other site 311403015928 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 311403015929 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 311403015930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403015931 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403015932 ABC transporter; Region: ABC_tran_2; pfam12848 311403015933 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403015934 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 311403015935 B1 nucleotide binding pocket [chemical binding]; other site 311403015936 B2 nucleotide binding pocket [chemical binding]; other site 311403015937 CAS motifs; other site 311403015938 active site 311403015939 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 311403015940 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 311403015941 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 311403015942 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403015943 EamA-like transporter family; Region: EamA; pfam00892 311403015944 EamA-like transporter family; Region: EamA; cl17759 311403015945 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 311403015946 CoA-transferase family III; Region: CoA_transf_3; pfam02515 311403015947 thiamine pyrophosphate protein; Validated; Region: PRK08199 311403015948 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403015949 PYR/PP interface [polypeptide binding]; other site 311403015950 dimer interface [polypeptide binding]; other site 311403015951 TPP binding site [chemical binding]; other site 311403015952 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 311403015953 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 311403015954 TPP-binding site [chemical binding]; other site 311403015955 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 311403015956 homotrimer interaction site [polypeptide binding]; other site 311403015957 putative active site [active] 311403015958 Putative phosphatase (DUF442); Region: DUF442; cl17385 311403015959 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 311403015960 active site 311403015961 catalytic residues [active] 311403015962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 311403015963 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 311403015964 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 311403015965 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 311403015966 putative active site [active] 311403015967 metal binding site [ion binding]; metal-binding site 311403015968 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 311403015969 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 311403015970 NAD(P) binding site [chemical binding]; other site 311403015971 catalytic residues [active] 311403015972 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 311403015973 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 311403015974 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 311403015975 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 311403015976 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 311403015977 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403015978 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403015979 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403015980 putative active site [active] 311403015981 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403015982 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403015983 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132 311403015984 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403015985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403015986 dimer interface [polypeptide binding]; other site 311403015987 conserved gate region; other site 311403015988 putative PBP binding loops; other site 311403015989 ABC-ATPase subunit interface; other site 311403015990 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403015991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403015992 Walker A/P-loop; other site 311403015993 ATP binding site [chemical binding]; other site 311403015994 Q-loop/lid; other site 311403015995 ABC transporter signature motif; other site 311403015996 Walker B; other site 311403015997 D-loop; other site 311403015998 H-loop/switch region; other site 311403015999 TOBE domain; Region: TOBE_2; pfam08402 311403016000 riboflavin synthase subunit beta; Provisional; Region: PRK12419 311403016001 active site 311403016002 homopentamer interface [polypeptide binding]; other site 311403016003 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 311403016004 dimer interface [polypeptide binding]; other site 311403016005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403016006 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 311403016007 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403016008 DNA-binding site [nucleotide binding]; DNA binding site 311403016009 UTRA domain; Region: UTRA; pfam07702 311403016010 Methyltransferase domain; Region: Methyltransf_23; pfam13489 311403016011 Methyltransferase domain; Region: Methyltransf_11; pfam08241 311403016012 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 311403016013 UbiA prenyltransferase family; Region: UbiA; pfam01040 311403016014 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403016015 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403016016 Walker A/P-loop; other site 311403016017 ATP binding site [chemical binding]; other site 311403016018 Q-loop/lid; other site 311403016019 ABC transporter signature motif; other site 311403016020 Walker B; other site 311403016021 D-loop; other site 311403016022 H-loop/switch region; other site 311403016023 TOBE domain; Region: TOBE_2; pfam08402 311403016024 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403016025 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403016026 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403016027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016028 dimer interface [polypeptide binding]; other site 311403016029 conserved gate region; other site 311403016030 putative PBP binding loops; other site 311403016031 ABC-ATPase subunit interface; other site 311403016032 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 311403016033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016034 dimer interface [polypeptide binding]; other site 311403016035 conserved gate region; other site 311403016036 putative PBP binding loops; other site 311403016037 ABC-ATPase subunit interface; other site 311403016038 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403016039 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403016040 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 311403016041 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 311403016042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403016043 DNA-binding site [nucleotide binding]; DNA binding site 311403016044 UTRA domain; Region: UTRA; pfam07702 311403016045 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 311403016046 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 311403016047 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 311403016048 substrate binding pocket [chemical binding]; other site 311403016049 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 311403016050 B12 binding site [chemical binding]; other site 311403016051 cobalt ligand [ion binding]; other site 311403016052 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 311403016053 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 311403016054 dimerization interface [polypeptide binding]; other site 311403016055 putative active cleft [active] 311403016056 hypothetical protein; Provisional; Region: PRK02487 311403016057 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 311403016058 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 311403016059 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 311403016060 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403016061 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 311403016062 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403016063 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 311403016064 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 311403016065 FMN binding site [chemical binding]; other site 311403016066 substrate binding site [chemical binding]; other site 311403016067 putative catalytic residue [active] 311403016068 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 311403016069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 311403016070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 311403016071 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 311403016072 Predicted methyltransferase [General function prediction only]; Region: COG3897 311403016073 Predicted transcriptional regulator [Transcription]; Region: COG2932 311403016074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403016075 non-specific DNA binding site [nucleotide binding]; other site 311403016076 salt bridge; other site 311403016077 sequence-specific DNA binding site [nucleotide binding]; other site 311403016078 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 311403016079 Catalytic site [active] 311403016080 MEKHLA domain; Region: MEKHLA; pfam08670 311403016081 Uncharacterized conserved protein [Function unknown]; Region: COG2968 311403016082 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 311403016083 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 311403016084 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 311403016085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403016086 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 311403016087 Coenzyme A binding pocket [chemical binding]; other site 311403016088 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403016089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403016090 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403016091 dimerization interface [polypeptide binding]; other site 311403016092 substrate binding pocket [chemical binding]; other site 311403016093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403016094 putative substrate translocation pore; other site 311403016095 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 311403016096 B3/4 domain; Region: B3_4; pfam03483 311403016097 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403016098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403016099 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403016100 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403016101 EamA-like transporter family; Region: EamA; pfam00892 311403016102 EamA-like transporter family; Region: EamA; pfam00892 311403016103 Domain of Unknown Function (DUF930); Region: DUF930; pfam06059 311403016104 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 311403016105 Phosphotransferase enzyme family; Region: APH; pfam01636 311403016106 active site 311403016107 ATP binding site [chemical binding]; other site 311403016108 antibiotic binding site [chemical binding]; other site 311403016109 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 311403016110 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 311403016111 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 311403016112 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 311403016113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403016114 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 311403016115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403016116 DNA binding residues [nucleotide binding] 311403016117 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 311403016118 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 311403016119 NAD(P) binding site [chemical binding]; other site 311403016120 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 311403016121 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 311403016122 substrate-cofactor binding pocket; other site 311403016123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403016124 catalytic residue [active] 311403016125 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 311403016126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403016127 NAD(P) binding site [chemical binding]; other site 311403016128 active site 311403016129 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 311403016130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403016131 ATP binding site [chemical binding]; other site 311403016132 putative Mg++ binding site [ion binding]; other site 311403016133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403016134 nucleotide binding region [chemical binding]; other site 311403016135 ATP-binding site [chemical binding]; other site 311403016136 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 311403016137 HRDC domain; Region: HRDC; pfam00570 311403016138 DNA primase; Validated; Region: dnaG; PRK05667 311403016139 CHC2 zinc finger; Region: zf-CHC2; cl17510 311403016140 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 311403016141 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 311403016142 active site 311403016143 metal binding site [ion binding]; metal-binding site 311403016144 interdomain interaction site; other site 311403016145 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 311403016146 Uncharacterized conserved protein [Function unknown]; Region: COG1610 311403016147 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 311403016148 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 311403016149 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 311403016150 catalytic site [active] 311403016151 subunit interface [polypeptide binding]; other site 311403016152 EVE domain; Region: EVE; cl00728 311403016153 multidrug efflux protein; Reviewed; Region: PRK01766 311403016154 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 311403016155 cation binding site [ion binding]; other site 311403016156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403016157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403016158 putative substrate translocation pore; other site 311403016159 Predicted metalloprotease [General function prediction only]; Region: COG2321 311403016160 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 311403016161 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 311403016162 LytTr DNA-binding domain; Region: LytTR; smart00850 311403016163 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 311403016164 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403016165 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403016166 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 311403016167 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403016168 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403016169 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 311403016170 IMP binding site; other site 311403016171 dimer interface [polypeptide binding]; other site 311403016172 partial ornithine binding site; other site 311403016173 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 311403016174 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 311403016175 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 311403016176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403016177 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 311403016178 Glycosyltransferase family 92; Region: Glyco_transf_92; pfam01697 311403016179 active site 311403016180 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 311403016181 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403016182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403016183 putative DNA binding site [nucleotide binding]; other site 311403016184 putative Zn2+ binding site [ion binding]; other site 311403016185 AsnC family; Region: AsnC_trans_reg; pfam01037 311403016186 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 311403016187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403016188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403016189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403016190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403016191 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403016192 putative effector binding pocket; other site 311403016193 dimerization interface [polypeptide binding]; other site 311403016194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403016195 dimerization interface [polypeptide binding]; other site 311403016196 putative DNA binding site [nucleotide binding]; other site 311403016197 putative Zn2+ binding site [ion binding]; other site 311403016198 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 311403016199 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 311403016200 FMN binding site [chemical binding]; other site 311403016201 active site 311403016202 substrate binding site [chemical binding]; other site 311403016203 catalytic residue [active] 311403016204 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 311403016205 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403016206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403016207 NAD(P) binding site [chemical binding]; other site 311403016208 active site 311403016209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403016210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403016211 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403016212 dimerization interface [polypeptide binding]; other site 311403016213 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 311403016214 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 311403016215 aspartate aminotransferase; Provisional; Region: PRK05764 311403016216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403016217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403016218 homodimer interface [polypeptide binding]; other site 311403016219 catalytic residue [active] 311403016220 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 311403016221 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 311403016222 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403016223 EamA-like transporter family; Region: EamA; pfam00892 311403016224 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403016225 DNA-binding site [nucleotide binding]; DNA binding site 311403016226 RNA-binding motif; other site 311403016227 BA14K-like protein; Region: BA14K; pfam07886 311403016228 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 311403016229 Bacterial SH3 domain; Region: SH3_3; pfam08239 311403016230 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 311403016231 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403016232 MarR family; Region: MarR_2; pfam12802 311403016233 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403016234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403016235 active site 311403016236 phosphorylation site [posttranslational modification] 311403016237 intermolecular recognition site; other site 311403016238 dimerization interface [polypeptide binding]; other site 311403016239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403016240 DNA binding site [nucleotide binding] 311403016241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403016242 HAMP domain; Region: HAMP; pfam00672 311403016243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403016244 ATP binding site [chemical binding]; other site 311403016245 Mg2+ binding site [ion binding]; other site 311403016246 G-X-G motif; other site 311403016247 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 311403016248 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 311403016249 dimer interface [polypeptide binding]; other site 311403016250 putative tRNA-binding site [nucleotide binding]; other site 311403016251 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 311403016252 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 311403016253 Uncharacterized conserved protein [Function unknown]; Region: COG5465 311403016254 Membrane fusogenic activity; Region: BMFP; pfam04380 311403016255 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 311403016256 Uncharacterized conserved protein [Function unknown]; Region: COG1565 311403016257 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 311403016258 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 311403016259 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 311403016260 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 311403016261 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 311403016262 active site 311403016263 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 311403016264 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 311403016265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403016266 active site 311403016267 H+ Antiporter protein; Region: 2A0121; TIGR00900 311403016268 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 311403016269 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 311403016270 5S rRNA interface [nucleotide binding]; other site 311403016271 CTC domain interface [polypeptide binding]; other site 311403016272 L16 interface [polypeptide binding]; other site 311403016273 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 311403016274 dimerization interface [polypeptide binding]; other site 311403016275 PAS domain S-box; Region: sensory_box; TIGR00229 311403016276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403016277 putative active site [active] 311403016278 heme pocket [chemical binding]; other site 311403016279 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403016280 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403016281 metal binding site [ion binding]; metal-binding site 311403016282 active site 311403016283 I-site; other site 311403016284 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403016285 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403016286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403016287 substrate binding pocket [chemical binding]; other site 311403016288 membrane-bound complex binding site; other site 311403016289 hinge residues; other site 311403016290 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 311403016291 putative active site [active] 311403016292 catalytic residue [active] 311403016293 putative acetyltransferase; Provisional; Region: PRK03624 311403016294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403016295 Coenzyme A binding pocket [chemical binding]; other site 311403016296 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 311403016297 GTP-binding protein YchF; Reviewed; Region: PRK09601 311403016298 YchF GTPase; Region: YchF; cd01900 311403016299 G1 box; other site 311403016300 GTP/Mg2+ binding site [chemical binding]; other site 311403016301 Switch I region; other site 311403016302 G2 box; other site 311403016303 Switch II region; other site 311403016304 G3 box; other site 311403016305 G4 box; other site 311403016306 G5 box; other site 311403016307 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 311403016308 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 311403016309 putative active site [active] 311403016310 putative catalytic site [active] 311403016311 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 311403016312 putative active site [active] 311403016313 putative catalytic site [active] 311403016314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403016315 active site 311403016316 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 311403016317 cytochrome b; Provisional; Region: CYTB; MTH00119 311403016318 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 311403016319 Qi binding site; other site 311403016320 intrachain domain interface; other site 311403016321 interchain domain interface [polypeptide binding]; other site 311403016322 heme bH binding site [chemical binding]; other site 311403016323 heme bL binding site [chemical binding]; other site 311403016324 Qo binding site; other site 311403016325 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 311403016326 interchain domain interface [polypeptide binding]; other site 311403016327 intrachain domain interface; other site 311403016328 Qi binding site; other site 311403016329 Qo binding site; other site 311403016330 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 311403016331 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 311403016332 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 311403016333 [2Fe-2S] cluster binding site [ion binding]; other site 311403016334 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 311403016335 putative catalytic site [active] 311403016336 putative metal binding site [ion binding]; other site 311403016337 putative phosphate binding site [ion binding]; other site 311403016338 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 311403016339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403016340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403016341 Walker A/P-loop; other site 311403016342 ATP binding site [chemical binding]; other site 311403016343 Q-loop/lid; other site 311403016344 ABC transporter signature motif; other site 311403016345 Walker B; other site 311403016346 D-loop; other site 311403016347 H-loop/switch region; other site 311403016348 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403016349 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403016350 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 311403016351 Walker A/P-loop; other site 311403016352 ATP binding site [chemical binding]; other site 311403016353 Q-loop/lid; other site 311403016354 ABC transporter signature motif; other site 311403016355 Walker B; other site 311403016356 D-loop; other site 311403016357 H-loop/switch region; other site 311403016358 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 311403016359 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 311403016360 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 311403016361 PhoU domain; Region: PhoU; pfam01895 311403016362 PhoU domain; Region: PhoU; pfam01895 311403016363 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 311403016364 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 311403016365 Predicted small metal-binding protein [Function unknown]; Region: COG5466 311403016366 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 311403016367 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 311403016368 active site 311403016369 NTP binding site [chemical binding]; other site 311403016370 metal binding triad [ion binding]; metal-binding site 311403016371 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 311403016372 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 311403016373 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 311403016374 putative active site [active] 311403016375 putative CoA binding site [chemical binding]; other site 311403016376 nudix motif; other site 311403016377 metal binding site [ion binding]; metal-binding site 311403016378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 311403016379 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 311403016380 MoxR-like ATPases [General function prediction only]; Region: COG0714 311403016381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 311403016382 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 311403016383 Protein of unknown function DUF58; Region: DUF58; pfam01882 311403016384 Aerotolerance regulator N-terminal; Region: BatA; cl06567 311403016385 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 311403016386 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 311403016387 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 311403016388 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403016389 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 311403016390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403016391 Coenzyme A binding pocket [chemical binding]; other site 311403016392 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 311403016393 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 311403016394 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 311403016395 putative dimer interface [polypeptide binding]; other site 311403016396 N-terminal domain interface [polypeptide binding]; other site 311403016397 putative substrate binding pocket (H-site) [chemical binding]; other site 311403016398 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 311403016399 nudix motif; other site 311403016400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403016401 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 311403016402 putative active site [active] 311403016403 putative metal binding site [ion binding]; other site 311403016404 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 311403016405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403016406 binding surface 311403016407 TPR repeat; Region: TPR_11; pfam13414 311403016408 TPR motif; other site 311403016409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403016410 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 311403016411 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403016412 DNA binding residues [nucleotide binding] 311403016413 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 311403016414 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 311403016415 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403016416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403016417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403016418 Walker A/P-loop; other site 311403016419 ATP binding site [chemical binding]; other site 311403016420 Q-loop/lid; other site 311403016421 ABC transporter signature motif; other site 311403016422 Walker B; other site 311403016423 D-loop; other site 311403016424 H-loop/switch region; other site 311403016425 2-isopropylmalate synthase; Validated; Region: PRK03739 311403016426 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 311403016427 active site 311403016428 catalytic residues [active] 311403016429 metal binding site [ion binding]; metal-binding site 311403016430 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 311403016431 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 311403016432 benzoate transporter; Region: benE; TIGR00843 311403016433 transcription elongation factor regulatory protein; Validated; Region: PRK06342 311403016434 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 311403016435 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 311403016436 Clp protease; Region: CLP_protease; pfam00574 311403016437 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 311403016438 oligomer interface [polypeptide binding]; other site 311403016439 active site residues [active] 311403016440 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 311403016441 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 311403016442 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 311403016443 Cation efflux family; Region: Cation_efflux; pfam01545 311403016444 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 311403016445 putative FMN binding site [chemical binding]; other site 311403016446 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 311403016447 dimer interface [polypeptide binding]; other site 311403016448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403016449 ligand binding site [chemical binding]; other site 311403016450 anthranilate synthase; Provisional; Region: PRK13566 311403016451 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 311403016452 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 311403016453 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 311403016454 glutamine binding [chemical binding]; other site 311403016455 catalytic triad [active] 311403016456 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 311403016457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403016458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403016459 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 311403016460 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 311403016461 N-terminal plug; other site 311403016462 ligand-binding site [chemical binding]; other site 311403016463 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 311403016464 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 311403016465 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 311403016466 Potassium binding sites [ion binding]; other site 311403016467 Cesium cation binding sites [ion binding]; other site 311403016468 hypothetical protein; Provisional; Region: PRK05208 311403016469 Predicted periplasmic protein [Function unknown]; Region: COG3904 311403016470 Autoinducer binding domain; Region: Autoind_bind; pfam03472 311403016471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403016472 DNA binding residues [nucleotide binding] 311403016473 dimerization interface [polypeptide binding]; other site 311403016474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345 311403016475 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 311403016476 active site 311403016477 metal binding site [ion binding]; metal-binding site 311403016478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403016479 Cytochrome c2 [Energy production and conversion]; Region: COG3474 311403016480 thymidine kinase; Provisional; Region: PRK04296 311403016481 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 311403016482 ATP binding site [chemical binding]; other site 311403016483 Walker A motif; other site 311403016484 Walker B motif; other site 311403016485 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 311403016486 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 311403016487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016488 dimer interface [polypeptide binding]; other site 311403016489 conserved gate region; other site 311403016490 putative PBP binding loops; other site 311403016491 ABC-ATPase subunit interface; other site 311403016492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403016493 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 311403016494 Walker A/P-loop; other site 311403016495 ATP binding site [chemical binding]; other site 311403016496 Q-loop/lid; other site 311403016497 ABC transporter signature motif; other site 311403016498 Walker B; other site 311403016499 D-loop; other site 311403016500 H-loop/switch region; other site 311403016501 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 311403016502 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 311403016503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403016504 dimerization interface [polypeptide binding]; other site 311403016505 putative DNA binding site [nucleotide binding]; other site 311403016506 putative Zn2+ binding site [ion binding]; other site 311403016507 omega amino acid--pyruvate transaminase; Provisional; Region: PRK13360 311403016508 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403016509 inhibitor-cofactor binding pocket; inhibition site 311403016510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403016511 catalytic residue [active] 311403016512 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 311403016513 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403016514 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 311403016515 active site 311403016516 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 311403016517 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 311403016518 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 311403016519 active site 311403016520 catalytic site [active] 311403016521 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 311403016522 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 311403016523 peptide binding site [polypeptide binding]; other site 311403016524 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 311403016525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016526 dimer interface [polypeptide binding]; other site 311403016527 conserved gate region; other site 311403016528 putative PBP binding loops; other site 311403016529 ABC-ATPase subunit interface; other site 311403016530 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 311403016531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016532 dimer interface [polypeptide binding]; other site 311403016533 conserved gate region; other site 311403016534 putative PBP binding loops; other site 311403016535 ABC-ATPase subunit interface; other site 311403016536 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403016537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403016538 Walker A/P-loop; other site 311403016539 ATP binding site [chemical binding]; other site 311403016540 Q-loop/lid; other site 311403016541 ABC transporter signature motif; other site 311403016542 Walker B; other site 311403016543 D-loop; other site 311403016544 H-loop/switch region; other site 311403016545 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 311403016546 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 311403016547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403016548 Walker A/P-loop; other site 311403016549 ATP binding site [chemical binding]; other site 311403016550 Q-loop/lid; other site 311403016551 ABC transporter signature motif; other site 311403016552 Walker B; other site 311403016553 D-loop; other site 311403016554 H-loop/switch region; other site 311403016555 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403016556 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 311403016557 substrate binding site [chemical binding]; other site 311403016558 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403016559 ATP binding site [chemical binding]; other site 311403016560 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 311403016561 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403016562 MarR family; Region: MarR; pfam01047 311403016563 GTP-binding protein Der; Reviewed; Region: PRK00093 311403016564 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 311403016565 G1 box; other site 311403016566 GTP/Mg2+ binding site [chemical binding]; other site 311403016567 Switch I region; other site 311403016568 G2 box; other site 311403016569 Switch II region; other site 311403016570 G3 box; other site 311403016571 G4 box; other site 311403016572 G5 box; other site 311403016573 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 311403016574 G1 box; other site 311403016575 GTP/Mg2+ binding site [chemical binding]; other site 311403016576 Switch I region; other site 311403016577 G2 box; other site 311403016578 G3 box; other site 311403016579 Switch II region; other site 311403016580 G4 box; other site 311403016581 G5 box; other site 311403016582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 311403016583 NnrU protein; Region: NnrU; pfam07298 311403016584 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 311403016585 NodB motif; other site 311403016586 putative active site [active] 311403016587 putative catalytic site [active] 311403016588 microcin B17 transporter; Reviewed; Region: PRK11098 311403016589 Predicted transcriptional regulators [Transcription]; Region: COG1695 311403016590 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 311403016591 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 311403016592 active site 311403016593 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403016594 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403016595 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 311403016596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403016597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403016598 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 311403016599 putative hydrophobic ligand binding site [chemical binding]; other site 311403016600 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 311403016601 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403016602 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 311403016603 DNA binding residues [nucleotide binding] 311403016604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403016605 TPR motif; other site 311403016606 binding surface 311403016607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 311403016608 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 311403016609 Beta-lactamase; Region: Beta-lactamase; pfam00144 311403016610 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 311403016611 dimer interface [polypeptide binding]; other site 311403016612 catalytic triad [active] 311403016613 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 311403016614 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 311403016615 N- and C-terminal domain interface [polypeptide binding]; other site 311403016616 active site 311403016617 MgATP binding site [chemical binding]; other site 311403016618 catalytic site [active] 311403016619 metal binding site [ion binding]; metal-binding site 311403016620 glycerol binding site [chemical binding]; other site 311403016621 homotetramer interface [polypeptide binding]; other site 311403016622 homodimer interface [polypeptide binding]; other site 311403016623 FBP binding site [chemical binding]; other site 311403016624 protein IIAGlc interface [polypeptide binding]; other site 311403016625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403016626 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 311403016627 NAD(P) binding site [chemical binding]; other site 311403016628 active site 311403016629 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 311403016630 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403016631 catalytic loop [active] 311403016632 iron binding site [ion binding]; other site 311403016633 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 311403016634 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 311403016635 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 311403016636 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 311403016637 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403016638 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 311403016639 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 311403016640 XdhC Rossmann domain; Region: XdhC_C; pfam13478 311403016641 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403016642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403016643 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 311403016644 dimerization interface [polypeptide binding]; other site 311403016645 substrate binding pocket [chemical binding]; other site 311403016646 Predicted membrane protein [Function unknown]; Region: COG3748 311403016647 Protein of unknown function (DUF989); Region: DUF989; pfam06181 311403016648 Cytochrome c; Region: Cytochrom_C; pfam00034 311403016649 guanine deaminase; Provisional; Region: PRK09228 311403016650 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 311403016651 active site 311403016652 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 311403016653 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 311403016654 active site 311403016655 substrate binding site [chemical binding]; other site 311403016656 FMN binding site [chemical binding]; other site 311403016657 putative catalytic residues [active] 311403016658 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 311403016659 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403016660 active site 311403016661 metal binding site [ion binding]; metal-binding site 311403016662 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 311403016663 active site 311403016664 homotetramer interface [polypeptide binding]; other site 311403016665 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 311403016666 ureidoglycolate hydrolase; Provisional; Region: PRK03606 311403016667 Protein of unknown function DUF86; Region: DUF86; cl01031 311403016668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 311403016669 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 311403016670 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 311403016671 active site 311403016672 catalytic site [active] 311403016673 tetramer interface [polypeptide binding]; other site 311403016674 Protein of unknown function (DUF1045); Region: DUF1045; pfam06299 311403016675 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403016676 Uncharacterized conserved protein [Function unknown]; Region: COG4121 311403016677 PAS domain S-box; Region: sensory_box; TIGR00229 311403016678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 311403016679 putative active site [active] 311403016680 heme pocket [chemical binding]; other site 311403016681 PAS domain; Region: PAS; smart00091 311403016682 PAS fold; Region: PAS_7; pfam12860 311403016683 PAS fold; Region: PAS_7; pfam12860 311403016684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403016685 dimer interface [polypeptide binding]; other site 311403016686 phosphorylation site [posttranslational modification] 311403016687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403016688 ATP binding site [chemical binding]; other site 311403016689 Mg2+ binding site [ion binding]; other site 311403016690 G-X-G motif; other site 311403016691 Response regulator receiver domain; Region: Response_reg; pfam00072 311403016692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403016693 active site 311403016694 phosphorylation site [posttranslational modification] 311403016695 intermolecular recognition site; other site 311403016696 dimerization interface [polypeptide binding]; other site 311403016697 Response regulator receiver domain; Region: Response_reg; pfam00072 311403016698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403016699 active site 311403016700 phosphorylation site [posttranslational modification] 311403016701 intermolecular recognition site; other site 311403016702 dimerization interface [polypeptide binding]; other site 311403016703 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 311403016704 helicase 45; Provisional; Region: PTZ00424 311403016705 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 311403016706 ATP binding site [chemical binding]; other site 311403016707 Mg++ binding site [ion binding]; other site 311403016708 motif III; other site 311403016709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403016710 nucleotide binding region [chemical binding]; other site 311403016711 ATP-binding site [chemical binding]; other site 311403016712 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 311403016713 EamA-like transporter family; Region: EamA; pfam00892 311403016714 EamA-like transporter family; Region: EamA; pfam00892 311403016715 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403016716 EamA-like transporter family; Region: EamA; pfam00892 311403016717 EamA-like transporter family; Region: EamA; pfam00892 311403016718 Uncharacterized conserved protein [Function unknown]; Region: COG2308 311403016719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 311403016720 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 311403016721 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 311403016722 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 311403016723 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 311403016724 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403016725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403016726 Walker A/P-loop; other site 311403016727 ATP binding site [chemical binding]; other site 311403016728 Q-loop/lid; other site 311403016729 ABC transporter signature motif; other site 311403016730 Walker B; other site 311403016731 D-loop; other site 311403016732 H-loop/switch region; other site 311403016733 dihydroxy-acid dehydratase; Validated; Region: PRK06131 311403016734 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 311403016735 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403016736 NAD(P) binding site [chemical binding]; other site 311403016737 catalytic residues [active] 311403016738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 311403016739 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 311403016740 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403016741 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403016742 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403016743 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403016744 TM-ABC transporter signature motif; other site 311403016745 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403016746 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403016747 Walker A/P-loop; other site 311403016748 ATP binding site [chemical binding]; other site 311403016749 Q-loop/lid; other site 311403016750 ABC transporter signature motif; other site 311403016751 Walker B; other site 311403016752 D-loop; other site 311403016753 H-loop/switch region; other site 311403016754 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403016755 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 311403016756 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 311403016757 putative ligand binding site [chemical binding]; other site 311403016758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403016759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403016760 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 311403016761 putative dimerization interface [polypeptide binding]; other site 311403016762 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403016763 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403016764 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403016765 MarR family; Region: MarR_2; pfam12802 311403016766 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403016767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 311403016768 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 311403016769 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 311403016770 putative ligand binding site [chemical binding]; other site 311403016771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403016772 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403016773 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403016774 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403016775 TM-ABC transporter signature motif; other site 311403016776 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403016777 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403016778 Walker A/P-loop; other site 311403016779 ATP binding site [chemical binding]; other site 311403016780 Q-loop/lid; other site 311403016781 ABC transporter signature motif; other site 311403016782 Walker B; other site 311403016783 D-loop; other site 311403016784 H-loop/switch region; other site 311403016785 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 311403016786 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 311403016787 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403016788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403016789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403016790 dimerization interface [polypeptide binding]; other site 311403016791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403016792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403016793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403016794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403016795 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 311403016796 putative substrate binding pocket [chemical binding]; other site 311403016797 putative dimerization interface [polypeptide binding]; other site 311403016798 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 311403016799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403016800 putative substrate translocation pore; other site 311403016801 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 311403016802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403016803 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 311403016804 active site 311403016805 Response regulator receiver domain; Region: Response_reg; pfam00072 311403016806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403016807 active site 311403016808 phosphorylation site [posttranslational modification] 311403016809 intermolecular recognition site; other site 311403016810 dimerization interface [polypeptide binding]; other site 311403016811 putative metal dependent hydrolase; Provisional; Region: PRK11598 311403016812 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 311403016813 Sulfatase; Region: Sulfatase; pfam00884 311403016814 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 311403016815 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403016816 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403016817 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403016818 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403016819 putative active site [active] 311403016820 Predicted membrane protein [Function unknown]; Region: COG4280 311403016821 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403016822 catalytic core [active] 311403016823 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 311403016824 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 311403016825 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403016826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403016827 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 311403016828 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403016829 DNA-binding site [nucleotide binding]; DNA binding site 311403016830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403016831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403016832 homodimer interface [polypeptide binding]; other site 311403016833 catalytic residue [active] 311403016834 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 311403016835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403016836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403016837 Coenzyme A binding pocket [chemical binding]; other site 311403016838 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 311403016839 nucleotide binding site/active site [active] 311403016840 HIT family signature motif; other site 311403016841 catalytic residue [active] 311403016842 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 311403016843 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 311403016844 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 311403016845 tetramer interface [polypeptide binding]; other site 311403016846 TPP-binding site [chemical binding]; other site 311403016847 heterodimer interface [polypeptide binding]; other site 311403016848 phosphorylation loop region [posttranslational modification] 311403016849 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 311403016850 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 311403016851 alpha subunit interface [polypeptide binding]; other site 311403016852 TPP binding site [chemical binding]; other site 311403016853 heterodimer interface [polypeptide binding]; other site 311403016854 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 311403016855 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403016856 carboxyltransferase (CT) interaction site; other site 311403016857 biotinylation site [posttranslational modification]; other site 311403016858 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 311403016859 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 311403016860 dimer interface [polypeptide binding]; other site 311403016861 active site 311403016862 CoA binding pocket [chemical binding]; other site 311403016863 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 311403016864 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 311403016865 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 311403016866 putative Cl- selectivity filter; other site 311403016867 putative pore gating glutamate residue; other site 311403016868 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403016869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403016870 S-adenosylmethionine binding site [chemical binding]; other site 311403016871 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403016872 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403016873 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403016874 Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813 311403016875 conserved cys residue [active] 311403016876 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 311403016877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403016878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403016879 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403016880 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403016881 Walker A/P-loop; other site 311403016882 ATP binding site [chemical binding]; other site 311403016883 Q-loop/lid; other site 311403016884 ABC transporter signature motif; other site 311403016885 Walker B; other site 311403016886 D-loop; other site 311403016887 H-loop/switch region; other site 311403016888 TOBE domain; Region: TOBE_2; pfam08402 311403016889 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403016890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016891 dimer interface [polypeptide binding]; other site 311403016892 conserved gate region; other site 311403016893 putative PBP binding loops; other site 311403016894 ABC-ATPase subunit interface; other site 311403016895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403016896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403016897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016898 dimer interface [polypeptide binding]; other site 311403016899 conserved gate region; other site 311403016900 putative PBP binding loops; other site 311403016901 ABC-ATPase subunit interface; other site 311403016902 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403016903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403016904 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403016905 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403016906 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403016907 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403016908 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403016909 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403016910 DNA binding site [nucleotide binding] 311403016911 domain linker motif; other site 311403016912 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 311403016913 ligand binding site [chemical binding]; other site 311403016914 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 311403016915 apolar tunnel; other site 311403016916 heme binding site [chemical binding]; other site 311403016917 dimerization interface [polypeptide binding]; other site 311403016918 Protein of unknown function (DUF423); Region: DUF423; cl01008 311403016919 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 311403016920 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 311403016921 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 311403016922 TonB C terminal; Region: TonB_2; pfam13103 311403016923 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 311403016924 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 311403016925 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 311403016926 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 311403016927 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 311403016928 putative hemin binding site; other site 311403016929 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 311403016930 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 311403016931 ABC-ATPase subunit interface; other site 311403016932 dimer interface [polypeptide binding]; other site 311403016933 putative PBP binding regions; other site 311403016934 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 311403016935 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 311403016936 Walker A/P-loop; other site 311403016937 ATP binding site [chemical binding]; other site 311403016938 Q-loop/lid; other site 311403016939 ABC transporter signature motif; other site 311403016940 Walker B; other site 311403016941 D-loop; other site 311403016942 H-loop/switch region; other site 311403016943 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 311403016944 RNA polymerase sigma factor; Provisional; Region: PRK12516 311403016945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403016946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403016947 DNA binding residues [nucleotide binding] 311403016948 two-component response regulator; Provisional; Region: PRK09191 311403016949 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 311403016950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403016951 active site 311403016952 phosphorylation site [posttranslational modification] 311403016953 intermolecular recognition site; other site 311403016954 dimerization interface [polypeptide binding]; other site 311403016955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 311403016956 HWE histidine kinase; Region: HWE_HK; pfam07536 311403016957 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 311403016958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403016959 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 311403016960 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 311403016961 homodimer interface [polypeptide binding]; other site 311403016962 active site 311403016963 FMN binding site [chemical binding]; other site 311403016964 substrate binding site [chemical binding]; other site 311403016965 4Fe-4S binding domain; Region: Fer4_6; pfam12837 311403016966 4Fe-4S binding domain; Region: Fer4; pfam00037 311403016967 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 311403016968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403016969 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 311403016970 allantoate amidohydrolase; Reviewed; Region: PRK12893 311403016971 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 311403016972 active site 311403016973 metal binding site [ion binding]; metal-binding site 311403016974 dimer interface [polypeptide binding]; other site 311403016975 phenylhydantoinase; Validated; Region: PRK08323 311403016976 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 311403016977 tetramer interface [polypeptide binding]; other site 311403016978 active site 311403016979 Cupin domain; Region: Cupin_2; cl17218 311403016980 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403016981 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403016982 Walker A/P-loop; other site 311403016983 ATP binding site [chemical binding]; other site 311403016984 Q-loop/lid; other site 311403016985 ABC transporter signature motif; other site 311403016986 Walker B; other site 311403016987 D-loop; other site 311403016988 H-loop/switch region; other site 311403016989 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403016990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016991 dimer interface [polypeptide binding]; other site 311403016992 conserved gate region; other site 311403016993 putative PBP binding loops; other site 311403016994 ABC-ATPase subunit interface; other site 311403016995 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403016996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403016997 dimer interface [polypeptide binding]; other site 311403016998 conserved gate region; other site 311403016999 putative PBP binding loops; other site 311403017000 ABC-ATPase subunit interface; other site 311403017001 NMT1/THI5 like; Region: NMT1; pfam09084 311403017002 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403017003 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403017004 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403017005 ABC-2 type transporter; Region: ABC2_membrane; cl17235 311403017006 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 311403017007 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 311403017008 UreF; Region: UreF; pfam01730 311403017009 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 311403017010 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 311403017011 dimer interface [polypeptide binding]; other site 311403017012 catalytic residues [active] 311403017013 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403017014 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403017015 metal binding site [ion binding]; metal-binding site 311403017016 active site 311403017017 I-site; other site 311403017018 Protein of unknown function (DUF2459); Region: DUF2459; cl09819 311403017019 urease subunit alpha; Reviewed; Region: ureC; PRK13207 311403017020 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 311403017021 subunit interactions [polypeptide binding]; other site 311403017022 active site 311403017023 flap region; other site 311403017024 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 311403017025 gamma-beta subunit interface [polypeptide binding]; other site 311403017026 alpha-beta subunit interface [polypeptide binding]; other site 311403017027 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 311403017028 alpha-gamma subunit interface [polypeptide binding]; other site 311403017029 beta-gamma subunit interface [polypeptide binding]; other site 311403017030 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 311403017031 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 311403017032 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403017033 Walker A/P-loop; other site 311403017034 ATP binding site [chemical binding]; other site 311403017035 Q-loop/lid; other site 311403017036 ABC transporter signature motif; other site 311403017037 Walker B; other site 311403017038 D-loop; other site 311403017039 H-loop/switch region; other site 311403017040 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 311403017041 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403017042 Walker A/P-loop; other site 311403017043 ATP binding site [chemical binding]; other site 311403017044 Q-loop/lid; other site 311403017045 ABC transporter signature motif; other site 311403017046 Walker B; other site 311403017047 D-loop; other site 311403017048 H-loop/switch region; other site 311403017049 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403017050 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403017051 TM-ABC transporter signature motif; other site 311403017052 HEAT repeats; Region: HEAT_2; pfam13646 311403017053 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403017054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403017055 TM-ABC transporter signature motif; other site 311403017056 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403017057 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 311403017058 putative ligand binding site [chemical binding]; other site 311403017059 Na binding site [ion binding]; other site 311403017060 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 311403017061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403017062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403017063 dimer interface [polypeptide binding]; other site 311403017064 phosphorylation site [posttranslational modification] 311403017065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403017066 ATP binding site [chemical binding]; other site 311403017067 Mg2+ binding site [ion binding]; other site 311403017068 G-X-G motif; other site 311403017069 Response regulator receiver domain; Region: Response_reg; pfam00072 311403017070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403017071 active site 311403017072 phosphorylation site [posttranslational modification] 311403017073 intermolecular recognition site; other site 311403017074 dimerization interface [polypeptide binding]; other site 311403017075 Response regulator receiver domain; Region: Response_reg; pfam00072 311403017076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403017077 active site 311403017078 phosphorylation site [posttranslational modification] 311403017079 intermolecular recognition site; other site 311403017080 dimerization interface [polypeptide binding]; other site 311403017081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403017082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403017083 DNA binding residues [nucleotide binding] 311403017084 dimerization interface [polypeptide binding]; other site 311403017085 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 311403017086 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 311403017087 dimerization interface [polypeptide binding]; other site 311403017088 ligand binding site [chemical binding]; other site 311403017089 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403017090 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403017091 Walker A/P-loop; other site 311403017092 ATP binding site [chemical binding]; other site 311403017093 Q-loop/lid; other site 311403017094 ABC transporter signature motif; other site 311403017095 Walker B; other site 311403017096 D-loop; other site 311403017097 H-loop/switch region; other site 311403017098 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403017099 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403017100 Walker A/P-loop; other site 311403017101 ATP binding site [chemical binding]; other site 311403017102 Q-loop/lid; other site 311403017103 ABC transporter signature motif; other site 311403017104 Walker B; other site 311403017105 D-loop; other site 311403017106 H-loop/switch region; other site 311403017107 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 311403017108 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 311403017109 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403017110 TM-ABC transporter signature motif; other site 311403017111 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403017112 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403017113 TM-ABC transporter signature motif; other site 311403017114 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403017115 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403017116 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 311403017117 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 311403017118 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 311403017119 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403017120 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 311403017121 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 311403017122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403017123 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403017124 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 311403017125 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 311403017126 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403017127 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 311403017128 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403017129 active site 311403017130 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 311403017131 Predicted acetyltransferase [General function prediction only]; Region: COG2388 311403017132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403017133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403017134 active site 311403017135 phosphorylation site [posttranslational modification] 311403017136 intermolecular recognition site; other site 311403017137 dimerization interface [polypeptide binding]; other site 311403017138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403017139 DNA binding site [nucleotide binding] 311403017140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403017141 Response regulator receiver domain; Region: Response_reg; pfam00072 311403017142 active site 311403017143 phosphorylation site [posttranslational modification] 311403017144 intermolecular recognition site; other site 311403017145 dimerization interface [polypeptide binding]; other site 311403017146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385 311403017147 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 311403017148 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 311403017149 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 311403017150 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 311403017151 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 311403017152 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403017153 RNA binding surface [nucleotide binding]; other site 311403017154 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 311403017155 active site 311403017156 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 311403017157 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 311403017158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403017159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403017160 DNA binding residues [nucleotide binding] 311403017161 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 311403017162 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 311403017163 GDP-binding site [chemical binding]; other site 311403017164 ACT binding site; other site 311403017165 IMP binding site; other site 311403017166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403017167 Coenzyme A binding pocket [chemical binding]; other site 311403017168 cytosine deaminase; Validated; Region: PRK07572 311403017169 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 311403017170 active site 311403017171 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 311403017172 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 311403017173 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 311403017174 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 311403017175 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403017176 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 311403017177 putative NAD(P) binding site [chemical binding]; other site 311403017178 active site 311403017179 putative substrate binding site [chemical binding]; other site 311403017180 Flavin Reductases; Region: FlaRed; cl00801 311403017181 Creatinine amidohydrolase; Region: Creatininase; pfam02633 311403017182 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403017183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403017184 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 311403017185 putative dimerization interface [polypeptide binding]; other site 311403017186 NMT1/THI5 like; Region: NMT1; pfam09084 311403017187 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403017188 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403017189 Walker A/P-loop; other site 311403017190 ATP binding site [chemical binding]; other site 311403017191 Q-loop/lid; other site 311403017192 ABC transporter signature motif; other site 311403017193 Walker B; other site 311403017194 D-loop; other site 311403017195 H-loop/switch region; other site 311403017196 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403017197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403017198 dimer interface [polypeptide binding]; other site 311403017199 conserved gate region; other site 311403017200 putative PBP binding loops; other site 311403017201 ABC-ATPase subunit interface; other site 311403017202 cytosine deaminase-like protein; Validated; Region: PRK07583 311403017203 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 311403017204 active site 311403017205 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 311403017206 FAD binding domain; Region: FAD_binding_4; pfam01565 311403017207 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 311403017208 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403017209 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 311403017210 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403017211 MarR family; Region: MarR_2; pfam12802 311403017212 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403017213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403017214 S-adenosylmethionine binding site [chemical binding]; other site 311403017215 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 311403017216 putative metal binding site [ion binding]; other site 311403017217 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403017218 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 311403017219 homotrimer interaction site [polypeptide binding]; other site 311403017220 putative active site [active] 311403017221 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403017222 EamA-like transporter family; Region: EamA; cl17759 311403017223 Predicted esterase [General function prediction only]; Region: COG0400 311403017224 putative hydrolase; Provisional; Region: PRK11460 311403017225 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 311403017226 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403017227 Zn binding site [ion binding]; other site 311403017228 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 311403017229 Zn binding site [ion binding]; other site 311403017230 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 311403017231 ligand binding site [chemical binding]; other site 311403017232 active site 311403017233 UGI interface [polypeptide binding]; other site 311403017234 catalytic site [active] 311403017235 hypothetical protein; Provisional; Region: PRK06834 311403017236 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403017237 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403017238 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403017239 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 311403017240 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 311403017241 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403017242 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 311403017243 Phosphotransferase enzyme family; Region: APH; pfam01636 311403017244 active site 311403017245 ATP binding site [chemical binding]; other site 311403017246 substrate binding site [chemical binding]; other site 311403017247 dimer interface [polypeptide binding]; other site 311403017248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403017249 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403017250 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403017251 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 311403017252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403017253 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 311403017254 putative dimerization interface [polypeptide binding]; other site 311403017255 PAS fold; Region: PAS_3; pfam08447 311403017256 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403017257 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403017258 metal binding site [ion binding]; metal-binding site 311403017259 active site 311403017260 I-site; other site 311403017261 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403017262 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 311403017263 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 311403017264 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 311403017265 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403017266 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 311403017267 putative NAD(P) binding site [chemical binding]; other site 311403017268 active site 311403017269 putative substrate binding site [chemical binding]; other site 311403017270 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 311403017271 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403017272 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403017273 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403017274 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 311403017275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403017276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403017277 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 311403017278 putative effector binding pocket; other site 311403017279 putative dimerization interface [polypeptide binding]; other site 311403017280 Uncharacterized conserved protein [Function unknown]; Region: COG2128 311403017281 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 311403017282 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 311403017283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403017284 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 311403017285 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403017286 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403017287 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403017288 EamA-like transporter family; Region: EamA; pfam00892 311403017289 EamA-like transporter family; Region: EamA; pfam00892 311403017290 MarR family; Region: MarR; pfam01047 311403017291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403017292 MarR family; Region: MarR; pfam01047 311403017293 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 311403017294 cyclase homology domain; Region: CHD; cd07302 311403017295 nucleotidyl binding site; other site 311403017296 metal binding site [ion binding]; metal-binding site 311403017297 dimer interface [polypeptide binding]; other site 311403017298 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 311403017299 NADP binding site [chemical binding]; other site 311403017300 active site 311403017301 steroid binding site; other site 311403017302 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 311403017303 short chain dehydrogenase; Provisional; Region: PRK12937 311403017304 NADP binding site [chemical binding]; other site 311403017305 homodimer interface [polypeptide binding]; other site 311403017306 active site 311403017307 substrate binding site [chemical binding]; other site 311403017308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403017309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403017310 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 311403017311 putative effector binding pocket; other site 311403017312 putative dimerization interface [polypeptide binding]; other site 311403017313 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403017314 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403017315 active site 311403017316 non-prolyl cis peptide bond; other site 311403017317 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 311403017318 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 311403017319 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 311403017320 MOFRL family; Region: MOFRL; pfam05161 311403017321 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 311403017322 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 311403017323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403017324 putative transporter; Provisional; Region: PRK10504 311403017325 putative substrate translocation pore; other site 311403017326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403017327 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 311403017328 DNA-binding site [nucleotide binding]; DNA binding site 311403017329 RNA-binding motif; other site 311403017330 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 311403017331 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403017332 Zn binding site [ion binding]; other site 311403017333 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 311403017334 Zn binding site [ion binding]; other site 311403017335 Predicted esterase [General function prediction only]; Region: COG0400 311403017336 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 311403017337 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403017338 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 311403017339 putative active site pocket [active] 311403017340 metal binding site [ion binding]; metal-binding site 311403017341 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 311403017342 CoA-transferase family III; Region: CoA_transf_3; pfam02515 311403017343 Uncharacterized conserved protein [Function unknown]; Region: COG2128 311403017344 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 311403017345 Cupin domain; Region: Cupin_2; cl17218 311403017346 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 311403017347 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 311403017348 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 311403017349 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 311403017350 Walker A/P-loop; other site 311403017351 ATP binding site [chemical binding]; other site 311403017352 Q-loop/lid; other site 311403017353 ABC transporter signature motif; other site 311403017354 Walker B; other site 311403017355 D-loop; other site 311403017356 H-loop/switch region; other site 311403017357 NIL domain; Region: NIL; pfam09383 311403017358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403017359 dimer interface [polypeptide binding]; other site 311403017360 conserved gate region; other site 311403017361 ABC-ATPase subunit interface; other site 311403017362 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403017363 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403017364 active site 311403017365 non-prolyl cis peptide bond; other site 311403017366 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 311403017367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403017368 substrate binding pocket [chemical binding]; other site 311403017369 membrane-bound complex binding site; other site 311403017370 hinge residues; other site 311403017371 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 311403017372 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403017373 Walker A/P-loop; other site 311403017374 ATP binding site [chemical binding]; other site 311403017375 Q-loop/lid; other site 311403017376 ABC transporter signature motif; other site 311403017377 Walker B; other site 311403017378 D-loop; other site 311403017379 H-loop/switch region; other site 311403017380 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403017381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403017382 dimer interface [polypeptide binding]; other site 311403017383 conserved gate region; other site 311403017384 putative PBP binding loops; other site 311403017385 ABC-ATPase subunit interface; other site 311403017386 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 311403017387 SPFH domain / Band 7 family; Region: Band_7; pfam01145 311403017388 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 311403017389 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 311403017390 putative ligand binding site [chemical binding]; other site 311403017391 putative NAD binding site [chemical binding]; other site 311403017392 catalytic site [active] 311403017393 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 311403017394 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 311403017395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403017396 putative substrate translocation pore; other site 311403017397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403017398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403017399 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 311403017400 Protein of unknown function (DUF982); Region: DUF982; pfam06169 311403017401 Porin subfamily; Region: Porin_2; pfam02530 311403017402 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 311403017403 active site 311403017404 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403017405 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403017406 active site 311403017407 DNA binding site [nucleotide binding] 311403017408 Int/Topo IB signature motif; other site 311403017409 Arc-like DNA binding domain; Region: Arc; pfam03869 311403017410 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 311403017411 tandem repeat interface [polypeptide binding]; other site 311403017412 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 311403017413 oligomer interface [polypeptide binding]; other site 311403017414 active site residues [active] 311403017415 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 311403017416 dimer interface [polypeptide binding]; other site 311403017417 ADP-ribose binding site [chemical binding]; other site 311403017418 active site 311403017419 nudix motif; other site 311403017420 metal binding site [ion binding]; metal-binding site 311403017421 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 311403017422 AAA-like domain; Region: AAA_10; pfam12846 311403017423 Divergent AAA domain; Region: AAA_4; pfam04326 311403017424 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 311403017425 DNA binding site [nucleotide binding] 311403017426 Int/Topo IB signature motif; other site 311403017427 active site 311403017428 catalytic residues [active] 311403017429 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 311403017430 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 311403017431 Ligand Binding Site [chemical binding]; other site 311403017432 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 311403017433 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 311403017434 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 311403017435 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 311403017436 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 311403017437 putative acyl-acceptor binding pocket; other site 311403017438 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 311403017439 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 311403017440 ligand binding site [chemical binding]; other site 311403017441 NAD binding site [chemical binding]; other site 311403017442 dimerization interface [polypeptide binding]; other site 311403017443 catalytic site [active] 311403017444 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 311403017445 putative L-serine binding site [chemical binding]; other site 311403017446 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 311403017447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403017448 catalytic residue [active] 311403017449 serC leader; predicted by Infernal 311403017450 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 311403017451 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 311403017452 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 311403017453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 311403017454 Bacterial SH3 domain; Region: SH3_4; pfam06347 311403017455 Bacterial SH3 domain; Region: SH3_4; pfam06347 311403017456 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403017457 MarR family; Region: MarR_2; cl17246 311403017458 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 311403017459 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 311403017460 active site 311403017461 substrate binding site [chemical binding]; other site 311403017462 metal binding site [ion binding]; metal-binding site 311403017463 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 311403017464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403017465 Walker A motif; other site 311403017466 ATP binding site [chemical binding]; other site 311403017467 Walker B motif; other site 311403017468 arginine finger; other site 311403017469 Peptidase family M41; Region: Peptidase_M41; pfam01434 311403017470 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 311403017471 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 311403017472 Ligand Binding Site [chemical binding]; other site 311403017473 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 311403017474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403017475 TPR motif; other site 311403017476 binding surface 311403017477 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 311403017478 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 311403017479 ligand binding site [chemical binding]; other site 311403017480 translocation protein TolB; Provisional; Region: tolB; PRK05137 311403017481 TolB amino-terminal domain; Region: TolB_N; pfam04052 311403017482 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 311403017483 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 311403017484 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 311403017485 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 311403017486 TolR protein; Region: tolR; TIGR02801 311403017487 TolQ protein; Region: tolQ; TIGR02796 311403017488 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 311403017489 active site 311403017490 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 311403017491 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403017492 NAD binding site [chemical binding]; other site 311403017493 substrate binding site [chemical binding]; other site 311403017494 active site 311403017495 Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; Region: GT8_Glycogenin; cd02537 311403017496 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 311403017497 substrate binding site; other site 311403017498 Manganese binding site; other site 311403017499 dimer interface; other site 311403017500 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403017501 extended (e) SDRs; Region: SDR_e; cd08946 311403017502 NAD(P) binding site [chemical binding]; other site 311403017503 active site 311403017504 substrate binding site [chemical binding]; other site 311403017505 BioY family; Region: BioY; pfam02632 311403017506 biotin synthase; Region: bioB; TIGR00433 311403017507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403017508 FeS/SAM binding site; other site 311403017509 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 311403017510 DinB family; Region: DinB; cl17821 311403017511 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 311403017512 nudix motif; other site 311403017513 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 311403017514 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403017515 putative active site [active] 311403017516 putative metal binding site [ion binding]; other site 311403017517 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 311403017518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403017519 Walker A motif; other site 311403017520 ATP binding site [chemical binding]; other site 311403017521 Walker B motif; other site 311403017522 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 311403017523 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 311403017524 RuvA N terminal domain; Region: RuvA_N; pfam01330 311403017525 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 311403017526 putative active site [active] 311403017527 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 311403017528 active site 311403017529 putative DNA-binding cleft [nucleotide binding]; other site 311403017530 dimer interface [polypeptide binding]; other site 311403017531 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 311403017532 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 311403017533 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403017534 hypothetical protein; Validated; Region: PRK00110 311403017535 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 311403017536 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 311403017537 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 311403017538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403017539 putative active site [active] 311403017540 metal binding site [ion binding]; metal-binding site 311403017541 homodimer binding site [polypeptide binding]; other site 311403017542 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 311403017543 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 311403017544 putative phosphatase; Provisional; Region: PRK11587 311403017545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403017546 motif II; other site 311403017547 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 311403017548 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 311403017549 Predicted integral membrane protein [Function unknown]; Region: COG0392 311403017550 Uncharacterized conserved protein [Function unknown]; Region: COG2898 311403017551 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 311403017552 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 311403017553 hydrophobic ligand binding site; other site 311403017554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403017555 putative DNA binding site [nucleotide binding]; other site 311403017556 putative Zn2+ binding site [ion binding]; other site 311403017557 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403017558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403017559 NAD(P) binding site [chemical binding]; other site 311403017560 active site 311403017561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 311403017562 short chain dehydrogenase; Provisional; Region: PRK06197 311403017563 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 311403017564 putative NAD(P) binding site [chemical binding]; other site 311403017565 active site 311403017566 short chain dehydrogenase; Provisional; Region: PRK07041 311403017567 classical (c) SDRs; Region: SDR_c; cd05233 311403017568 NAD(P) binding site [chemical binding]; other site 311403017569 active site 311403017570 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403017571 MarR family; Region: MarR_2; pfam12802 311403017572 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 311403017573 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 311403017574 Cl- selectivity filter; other site 311403017575 Cl- binding residues [ion binding]; other site 311403017576 pore gating glutamate residue; other site 311403017577 dimer interface [polypeptide binding]; other site 311403017578 FOG: CBS domain [General function prediction only]; Region: COG0517 311403017579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 311403017580 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 311403017581 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 311403017582 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 311403017583 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 311403017584 TPP-binding site [chemical binding]; other site 311403017585 dimer interface [polypeptide binding]; other site 311403017586 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 311403017587 PYR/PP interface [polypeptide binding]; other site 311403017588 dimer interface [polypeptide binding]; other site 311403017589 TPP binding site [chemical binding]; other site 311403017590 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 311403017591 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 311403017592 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 311403017593 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 311403017594 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 311403017595 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 311403017596 Transporter associated domain; Region: CorC_HlyC; smart01091 311403017597 Phosphoglycerate kinase; Region: PGK; pfam00162 311403017598 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 311403017599 substrate binding site [chemical binding]; other site 311403017600 hinge regions; other site 311403017601 ADP binding site [chemical binding]; other site 311403017602 catalytic site [active] 311403017603 Class I aldolases; Region: Aldolase_Class_I; cl17187 311403017604 catalytic residue [active] 311403017605 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 311403017606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403017607 putative substrate translocation pore; other site 311403017608 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 311403017609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317 311403017610 SnoaL-like domain; Region: SnoaL_3; pfam13474 311403017611 SnoaL-like domain; Region: SnoaL_2; pfam12680 311403017612 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 311403017613 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 311403017614 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403017615 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 311403017616 Walker A/P-loop; other site 311403017617 ATP binding site [chemical binding]; other site 311403017618 Q-loop/lid; other site 311403017619 ABC transporter signature motif; other site 311403017620 Walker B; other site 311403017621 D-loop; other site 311403017622 H-loop/switch region; other site 311403017623 Uncharacterized conserved protein [Function unknown]; Region: COG3422 311403017624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 311403017625 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 311403017626 hypothetical protein; Validated; Region: PRK09039 311403017627 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 311403017628 ligand binding site [chemical binding]; other site 311403017629 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403017630 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 311403017631 active site 311403017632 dimerization interface [polypeptide binding]; other site 311403017633 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 311403017634 RNA polymerase sigma factor; Provisional; Region: PRK12512 311403017635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403017636 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403017637 DNA binding residues [nucleotide binding] 311403017638 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 311403017639 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403017640 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 311403017641 Sel1-like repeats; Region: SEL1; smart00671 311403017642 Sel1-like repeats; Region: SEL1; smart00671 311403017643 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 311403017644 thiamine phosphate binding site [chemical binding]; other site 311403017645 active site 311403017646 pyrophosphate binding site [ion binding]; other site 311403017647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403017648 dimerization interface [polypeptide binding]; other site 311403017649 putative DNA binding site [nucleotide binding]; other site 311403017650 putative Zn2+ binding site [ion binding]; other site 311403017651 Uncharacterized small protein [Function unknown]; Region: COG5570 311403017652 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 311403017653 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 311403017654 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 311403017655 ATP-grasp domain; Region: ATP-grasp; pfam02222 311403017656 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 311403017657 TPR repeat; Region: TPR_11; pfam13414 311403017658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403017659 binding surface 311403017660 TPR motif; other site 311403017661 TPR repeat; Region: TPR_11; pfam13414 311403017662 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 311403017663 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 311403017664 catalytic site [active] 311403017665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403017666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403017667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403017668 dimerization interface [polypeptide binding]; other site 311403017669 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 311403017670 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 311403017671 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 311403017672 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 311403017673 tetramer interface [polypeptide binding]; other site 311403017674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403017675 catalytic residue [active] 311403017676 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403017677 pyruvate kinase; Provisional; Region: PRK06247 311403017678 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 311403017679 domain interfaces; other site 311403017680 active site 311403017681 Predicted integral membrane protein [Function unknown]; Region: COG5480 311403017682 Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931 311403017683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 311403017684 hypothetical protein; Provisional; Region: PRK13694 311403017685 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 311403017686 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 311403017687 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 311403017688 Protein of unknown function (DUF461); Region: DUF461; pfam04314 311403017689 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 311403017690 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 311403017691 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 311403017692 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 311403017693 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 311403017694 Cu(I) binding site [ion binding]; other site 311403017695 CopC domain; Region: CopC; pfam04234 311403017696 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 311403017697 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 311403017698 putative active site [active] 311403017699 putative metal binding site [ion binding]; other site 311403017700 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 311403017701 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 311403017702 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 311403017703 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 311403017704 active site 311403017705 substrate binding site [chemical binding]; other site 311403017706 cosubstrate binding site; other site 311403017707 catalytic site [active] 311403017708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 311403017709 Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951 311403017710 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 311403017711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403017712 active site 311403017713 phosphorylation site [posttranslational modification] 311403017714 intermolecular recognition site; other site 311403017715 dimerization interface [polypeptide binding]; other site 311403017716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403017717 Walker A motif; other site 311403017718 ATP binding site [chemical binding]; other site 311403017719 Walker B motif; other site 311403017720 arginine finger; other site 311403017721 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 311403017722 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 311403017723 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 311403017724 active site 311403017725 Zn binding site [ion binding]; other site 311403017726 aminodeoxychorismate synthase; Provisional; Region: PRK07508 311403017727 chorismate binding enzyme; Region: Chorismate_bind; cl10555 311403017728 hypothetical protein; Provisional; Region: PRK07546 311403017729 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 311403017730 substrate-cofactor binding pocket; other site 311403017731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403017732 homodimer interface [polypeptide binding]; other site 311403017733 catalytic residue [active] 311403017734 YCII-related domain; Region: YCII; cl00999 311403017735 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 311403017736 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 311403017737 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 311403017738 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 311403017739 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 311403017740 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 311403017741 active site 311403017742 metal binding site [ion binding]; metal-binding site 311403017743 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 311403017744 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 311403017745 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 311403017746 ferrochelatase; Reviewed; Region: hemH; PRK00035 311403017747 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 311403017748 C-terminal domain interface [polypeptide binding]; other site 311403017749 active site 311403017750 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 311403017751 active site 311403017752 N-terminal domain interface [polypeptide binding]; other site 311403017753 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 311403017754 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 311403017755 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 311403017756 protein binding site [polypeptide binding]; other site 311403017757 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 311403017758 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 311403017759 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 311403017760 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 311403017761 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 311403017762 putative active site [active] 311403017763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 311403017764 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 311403017765 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 311403017766 active site 311403017767 tetramer interface; other site 311403017768 Transglycosylase SLT domain; Region: SLT_2; pfam13406 311403017769 murein hydrolase B; Provisional; Region: PRK10760; cl17906 311403017770 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 311403017771 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 311403017772 active site 311403017773 catalytic triad [active] 311403017774 oxyanion hole [active] 311403017775 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 311403017776 active site 311403017777 dimer interface [polypeptide binding]; other site 311403017778 motif 2; other site 311403017779 motif 3; other site 311403017780 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 311403017781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403017782 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 311403017783 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 311403017784 active site 311403017785 dimer interface [polypeptide binding]; other site 311403017786 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 311403017787 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 311403017788 active site 311403017789 FMN binding site [chemical binding]; other site 311403017790 substrate binding site [chemical binding]; other site 311403017791 3Fe-4S cluster binding site [ion binding]; other site 311403017792 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 311403017793 domain interface; other site 311403017794 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 311403017795 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 311403017796 tetramer interface [polypeptide binding]; other site 311403017797 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403017798 catalytic residue [active] 311403017799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403017800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403017801 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403017802 dimerization interface [polypeptide binding]; other site 311403017803 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 311403017804 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 311403017805 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 311403017806 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 311403017807 putative dimer interface [polypeptide binding]; other site 311403017808 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 311403017809 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403017810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403017811 putative DNA binding site [nucleotide binding]; other site 311403017812 putative Zn2+ binding site [ion binding]; other site 311403017813 AsnC family; Region: AsnC_trans_reg; pfam01037 311403017814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 311403017815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403017816 Coenzyme A binding pocket [chemical binding]; other site 311403017817 Ion channel; Region: Ion_trans_2; pfam07885 311403017818 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403017819 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403017820 ligand binding site [chemical binding]; other site 311403017821 flexible hinge region; other site 311403017822 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 311403017823 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 311403017824 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403017825 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 311403017826 active site 311403017827 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 311403017828 Response regulator receiver domain; Region: Response_reg; pfam00072 311403017829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403017830 active site 311403017831 phosphorylation site [posttranslational modification] 311403017832 intermolecular recognition site; other site 311403017833 dimerization interface [polypeptide binding]; other site 311403017834 hypothetical protein; Provisional; Region: PRK14013 311403017835 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 311403017836 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 311403017837 Substrate binding site; other site 311403017838 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 311403017839 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 311403017840 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 311403017841 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 311403017842 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 311403017843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 311403017844 Uncharacterized conserved protein [Function unknown]; Region: COG2308 311403017845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 311403017846 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 311403017847 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 311403017848 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 311403017849 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 311403017850 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 311403017851 metal ion-dependent adhesion site (MIDAS); other site 311403017852 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 311403017853 homodimer interface [polypeptide binding]; other site 311403017854 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 311403017855 active site pocket [active] 311403017856 glycogen branching enzyme; Provisional; Region: PRK05402 311403017857 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 311403017858 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 311403017859 active site 311403017860 catalytic site [active] 311403017861 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 311403017862 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 311403017863 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 311403017864 ligand binding site; other site 311403017865 oligomer interface; other site 311403017866 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 311403017867 dimer interface [polypeptide binding]; other site 311403017868 N-terminal domain interface [polypeptide binding]; other site 311403017869 sulfate 1 binding site; other site 311403017870 glycogen synthase; Provisional; Region: glgA; PRK00654 311403017871 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 311403017872 ADP-binding pocket [chemical binding]; other site 311403017873 homodimer interface [polypeptide binding]; other site 311403017874 phosphoglucomutase; Region: PLN02307 311403017875 Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085 311403017876 substrate binding site [chemical binding]; other site 311403017877 dimer interface [polypeptide binding]; other site 311403017878 active site 311403017879 metal binding site [ion binding]; metal-binding site 311403017880 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 311403017881 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 311403017882 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 311403017883 active site 311403017884 catalytic site [active] 311403017885 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 311403017886 putative active site [active] 311403017887 putative catalytic site [active] 311403017888 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 311403017889 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 311403017890 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 311403017891 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 311403017892 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 311403017893 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 311403017894 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403017895 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 311403017896 TPR repeat; Region: TPR_11; pfam13414 311403017897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403017898 TPR motif; other site 311403017899 binding surface 311403017900 TPR repeat; Region: TPR_11; pfam13414 311403017901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403017902 binding surface 311403017903 TPR motif; other site 311403017904 TPR repeat; Region: TPR_11; pfam13414 311403017905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403017906 TPR repeat; Region: TPR_11; pfam13414 311403017907 binding surface 311403017908 TPR motif; other site 311403017909 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403017910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403017911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 311403017912 HWE histidine kinase; Region: HWE_HK; smart00911 311403017913 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 311403017914 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 311403017915 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 311403017916 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 311403017917 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 311403017918 ligand binding site [chemical binding]; other site 311403017919 homodimer interface [polypeptide binding]; other site 311403017920 NAD(P) binding site [chemical binding]; other site 311403017921 trimer interface B [polypeptide binding]; other site 311403017922 trimer interface A [polypeptide binding]; other site 311403017923 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 311403017924 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 311403017925 PAS domain; Region: PAS; smart00091 311403017926 PAS fold; Region: PAS_7; pfam12860 311403017927 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 311403017928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403017929 metal binding site [ion binding]; metal-binding site 311403017930 active site 311403017931 I-site; other site 311403017932 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403017933 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 311403017934 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 311403017935 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 311403017936 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 311403017937 catalytic triad [active] 311403017938 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 311403017939 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 311403017940 putative ligand binding site [chemical binding]; other site 311403017941 NAD binding site [chemical binding]; other site 311403017942 catalytic site [active] 311403017943 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403017944 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403017945 DNA binding site [nucleotide binding] 311403017946 domain linker motif; other site 311403017947 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 311403017948 putative dimerization interface [polypeptide binding]; other site 311403017949 putative ligand binding site [chemical binding]; other site 311403017950 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403017951 MarR family; Region: MarR_2; pfam12802 311403017952 Creatinine amidohydrolase; Region: Creatininase; pfam02633 311403017953 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 311403017954 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 311403017955 P-loop, Walker A motif; other site 311403017956 Base recognition motif; other site 311403017957 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 311403017958 FOG: WD40 repeat [General function prediction only]; Region: COG2319 311403017959 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 311403017960 structural tetrad; other site 311403017961 serine acetyltransferase; Provisional; Region: cysE; PRK11132 311403017962 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 311403017963 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 311403017964 trimer interface [polypeptide binding]; other site 311403017965 active site 311403017966 substrate binding site [chemical binding]; other site 311403017967 CoA binding site [chemical binding]; other site 311403017968 Phosphoesterase family; Region: Phosphoesterase; pfam04185 311403017969 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 311403017970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403017971 Coenzyme A binding pocket [chemical binding]; other site 311403017972 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 311403017973 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 311403017974 active site 311403017975 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 311403017976 dimer interface [polypeptide binding]; other site 311403017977 catalytic residues [active] 311403017978 substrate binding site [chemical binding]; other site 311403017979 speF leader; predicted by Infernal 311403017980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403017981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403017982 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403017983 putative effector binding pocket; other site 311403017984 dimerization interface [polypeptide binding]; other site 311403017985 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 311403017986 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 311403017987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 311403017988 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 311403017989 putative metal binding site [ion binding]; other site 311403017990 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 311403017991 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 311403017992 active site 311403017993 intersubunit interface [polypeptide binding]; other site 311403017994 catalytic residue [active] 311403017995 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 311403017996 putative active site [active] 311403017997 putative metal binding residues [ion binding]; other site 311403017998 signature motif; other site 311403017999 putative dimer interface [polypeptide binding]; other site 311403018000 putative phosphate binding site [ion binding]; other site 311403018001 CHAD domain; Region: CHAD; pfam05235 311403018002 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 311403018003 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 311403018004 active site residue [active] 311403018005 CHASE4 domain; Region: CHASE4; pfam05228 311403018006 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 311403018007 metal binding site [ion binding]; metal-binding site 311403018008 active site 311403018009 I-site; other site 311403018010 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 311403018011 Predicted flavoprotein [General function prediction only]; Region: COG0431 311403018012 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403018013 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 311403018014 beta-galactosidase; Region: BGL; TIGR03356 311403018015 Predicted membrane protein [Function unknown]; Region: COG2259 311403018016 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403018017 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403018018 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403018019 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403018020 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403018021 Metal-binding active site; metal-binding site 311403018022 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 311403018023 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403018024 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 311403018025 putative ligand binding site [chemical binding]; other site 311403018026 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403018027 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403018028 TM-ABC transporter signature motif; other site 311403018029 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403018030 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403018031 Walker A/P-loop; other site 311403018032 ATP binding site [chemical binding]; other site 311403018033 Q-loop/lid; other site 311403018034 ABC transporter signature motif; other site 311403018035 Walker B; other site 311403018036 D-loop; other site 311403018037 H-loop/switch region; other site 311403018038 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403018039 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403018040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403018041 DNA binding site [nucleotide binding] 311403018042 domain linker motif; other site 311403018043 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 311403018044 dimerization interface [polypeptide binding]; other site 311403018045 ligand binding site [chemical binding]; other site 311403018046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403018047 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403018048 active site 311403018049 xylose isomerase; Provisional; Region: PRK05474 311403018050 xylose isomerase; Region: xylose_isom_A; TIGR02630 311403018051 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 311403018052 N- and C-terminal domain interface [polypeptide binding]; other site 311403018053 D-xylulose kinase; Region: XylB; TIGR01312 311403018054 active site 311403018055 MgATP binding site [chemical binding]; other site 311403018056 catalytic site [active] 311403018057 metal binding site [ion binding]; metal-binding site 311403018058 xylulose binding site [chemical binding]; other site 311403018059 homodimer interface [polypeptide binding]; other site 311403018060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403018061 DNA binding site [nucleotide binding] 311403018062 domain linker motif; other site 311403018063 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 311403018064 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403018065 putative ligand binding site [chemical binding]; other site 311403018066 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 311403018067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403018068 putative substrate translocation pore; other site 311403018069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403018070 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 311403018071 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403018072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403018073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403018074 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 311403018075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403018076 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403018077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403018078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 311403018079 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 311403018080 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 311403018081 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 311403018082 HIGH motif; other site 311403018083 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 311403018084 active site 311403018085 KMSKS motif; other site 311403018086 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 311403018087 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 311403018088 dimer interface [polypeptide binding]; other site 311403018089 putative anticodon binding site; other site 311403018090 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 311403018091 motif 1; other site 311403018092 active site 311403018093 motif 2; other site 311403018094 motif 3; other site 311403018095 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403018096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403018097 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403018098 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403018099 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403018100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403018101 DNA binding site [nucleotide binding] 311403018102 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 311403018103 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403018104 putative ligand binding site [chemical binding]; other site 311403018105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403018106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403018107 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 311403018108 putative substrate binding pocket [chemical binding]; other site 311403018109 dimerization interface [polypeptide binding]; other site 311403018110 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403018111 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403018112 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403018113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403018114 Walker A/P-loop; other site 311403018115 ATP binding site [chemical binding]; other site 311403018116 Q-loop/lid; other site 311403018117 ABC transporter signature motif; other site 311403018118 Walker B; other site 311403018119 D-loop; other site 311403018120 H-loop/switch region; other site 311403018121 TOBE domain; Region: TOBE_2; pfam08402 311403018122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018123 dimer interface [polypeptide binding]; other site 311403018124 conserved gate region; other site 311403018125 putative PBP binding loops; other site 311403018126 ABC-ATPase subunit interface; other site 311403018127 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 311403018128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018129 dimer interface [polypeptide binding]; other site 311403018130 conserved gate region; other site 311403018131 putative PBP binding loops; other site 311403018132 ABC-ATPase subunit interface; other site 311403018133 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 311403018134 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 311403018135 tetrameric interface [polypeptide binding]; other site 311403018136 NAD binding site [chemical binding]; other site 311403018137 catalytic residues [active] 311403018138 substrate binding site [chemical binding]; other site 311403018139 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 311403018140 short chain dehydrogenase; Provisional; Region: PRK06138 311403018141 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 311403018142 NAD binding site [chemical binding]; other site 311403018143 homotetramer interface [polypeptide binding]; other site 311403018144 homodimer interface [polypeptide binding]; other site 311403018145 active site 311403018146 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403018147 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 311403018148 active site 2 [active] 311403018149 active site 1 [active] 311403018150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403018151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403018152 Uncharacterized conserved protein [Function unknown]; Region: COG3254 311403018153 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403018154 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 311403018155 active site pocket [active] 311403018156 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403018157 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403018158 Walker A/P-loop; other site 311403018159 ATP binding site [chemical binding]; other site 311403018160 Q-loop/lid; other site 311403018161 ABC transporter signature motif; other site 311403018162 Walker B; other site 311403018163 D-loop; other site 311403018164 H-loop/switch region; other site 311403018165 TOBE domain; Region: TOBE_2; pfam08402 311403018166 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403018167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018168 dimer interface [polypeptide binding]; other site 311403018169 conserved gate region; other site 311403018170 putative PBP binding loops; other site 311403018171 ABC-ATPase subunit interface; other site 311403018172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018173 dimer interface [polypeptide binding]; other site 311403018174 conserved gate region; other site 311403018175 putative PBP binding loops; other site 311403018176 ABC-ATPase subunit interface; other site 311403018177 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403018178 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403018179 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403018180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403018181 putative DNA binding site [nucleotide binding]; other site 311403018182 putative Zn2+ binding site [ion binding]; other site 311403018183 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403018184 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 311403018185 Amidohydrolase; Region: Amidohydro_2; pfam04909 311403018186 Acyl dehydratase [Lipid metabolism]; Region: MaoC; COG2030 311403018187 active site 2 [active] 311403018188 active site 1 [active] 311403018189 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 311403018190 CoA-transferase family III; Region: CoA_transf_3; pfam02515 311403018191 transaldolase-like protein; Provisional; Region: PTZ00411 311403018192 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 311403018193 active site 311403018194 dimer interface [polypeptide binding]; other site 311403018195 catalytic residue [active] 311403018196 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403018197 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 311403018198 DNA binding residues [nucleotide binding] 311403018199 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403018200 DinB family; Region: DinB; cl17821 311403018201 DinB superfamily; Region: DinB_2; pfam12867 311403018202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403018203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403018204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403018205 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403018206 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 311403018207 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 311403018208 DNA binding site [nucleotide binding] 311403018209 active site 311403018210 Integral membrane protein [Function unknown]; Region: COG5488 311403018211 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 311403018212 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 311403018213 minor groove reading motif; other site 311403018214 helix-hairpin-helix signature motif; other site 311403018215 substrate binding pocket [chemical binding]; other site 311403018216 active site 311403018217 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 311403018218 CysZ-like protein; Reviewed; Region: PRK12768 311403018219 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 311403018220 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 311403018221 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 311403018222 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 311403018223 N- and C-terminal domain interface [polypeptide binding]; other site 311403018224 active site 311403018225 MgATP binding site [chemical binding]; other site 311403018226 catalytic site [active] 311403018227 metal binding site [ion binding]; metal-binding site 311403018228 carbohydrate binding site [chemical binding]; other site 311403018229 putative homodimer interface [polypeptide binding]; other site 311403018230 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 311403018231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403018232 active site 311403018233 motif II; other site 311403018234 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 311403018235 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 311403018236 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 311403018237 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403018238 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403018239 Walker A/P-loop; other site 311403018240 ATP binding site [chemical binding]; other site 311403018241 Q-loop/lid; other site 311403018242 ABC transporter signature motif; other site 311403018243 Walker B; other site 311403018244 D-loop; other site 311403018245 H-loop/switch region; other site 311403018246 TOBE domain; Region: TOBE_2; pfam08402 311403018247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403018248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018249 dimer interface [polypeptide binding]; other site 311403018250 conserved gate region; other site 311403018251 putative PBP binding loops; other site 311403018252 ABC-ATPase subunit interface; other site 311403018253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018254 dimer interface [polypeptide binding]; other site 311403018255 conserved gate region; other site 311403018256 putative PBP binding loops; other site 311403018257 ABC-ATPase subunit interface; other site 311403018258 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403018259 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403018260 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403018261 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403018262 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 311403018263 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403018264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403018265 active site 311403018266 phosphorylation site [posttranslational modification] 311403018267 intermolecular recognition site; other site 311403018268 dimerization interface [polypeptide binding]; other site 311403018269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403018270 DNA binding site [nucleotide binding] 311403018271 sensor protein QseC; Provisional; Region: PRK10337 311403018272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403018273 dimer interface [polypeptide binding]; other site 311403018274 phosphorylation site [posttranslational modification] 311403018275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403018276 ATP binding site [chemical binding]; other site 311403018277 Mg2+ binding site [ion binding]; other site 311403018278 G-X-G motif; other site 311403018279 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403018280 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403018281 nucleotide binding site [chemical binding]; other site 311403018282 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 311403018283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403018284 putative transporter; Provisional; Region: PRK10504 311403018285 putative substrate translocation pore; other site 311403018286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403018287 SpoVR family protein; Provisional; Region: PRK11767 311403018288 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 311403018289 hypothetical protein; Provisional; Region: PRK05325 311403018290 PrkA family serine protein kinase; Provisional; Region: PRK15455 311403018291 AAA ATPase domain; Region: AAA_16; pfam13191 311403018292 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 311403018293 zinc-binding protein; Provisional; Region: PRK01343 311403018294 Maf-like protein; Region: Maf; pfam02545 311403018295 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 311403018296 active site 311403018297 dimer interface [polypeptide binding]; other site 311403018298 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 311403018299 rRNA binding site [nucleotide binding]; other site 311403018300 predicted 30S ribosome binding site; other site 311403018301 Low molecular weight phosphatase family; Region: LMWPc; cl00105 311403018302 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 311403018303 active site 311403018304 hypothetical protein; Provisional; Region: PRK02853 311403018305 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 311403018306 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 311403018307 NAD binding site [chemical binding]; other site 311403018308 dimerization interface [polypeptide binding]; other site 311403018309 product binding site; other site 311403018310 substrate binding site [chemical binding]; other site 311403018311 zinc binding site [ion binding]; other site 311403018312 catalytic residues [active] 311403018313 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 311403018314 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 311403018315 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 311403018316 hinge; other site 311403018317 active site 311403018318 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 311403018319 dimer interface [polypeptide binding]; other site 311403018320 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403018321 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403018322 active site 311403018323 metal binding site [ion binding]; metal-binding site 311403018324 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403018325 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 311403018326 active site 311403018327 metal binding site [ion binding]; metal-binding site 311403018328 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403018329 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403018330 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403018331 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403018332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403018333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403018334 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 311403018335 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403018336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403018337 DNA-binding site [nucleotide binding]; DNA binding site 311403018338 FCD domain; Region: FCD; pfam07729 311403018339 galactonate dehydratase; Provisional; Region: PRK14017 311403018340 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 311403018341 putative active site pocket [active] 311403018342 putative metal binding site [ion binding]; other site 311403018343 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 311403018344 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 311403018345 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 311403018346 RNA polymerase sigma factor; Provisional; Region: PRK12511 311403018347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403018348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403018349 DNA binding residues [nucleotide binding] 311403018350 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 311403018351 methionine sulfoxide reductase A; Provisional; Region: PRK13014 311403018352 hypothetical protein; Provisional; Region: PRK00736 311403018353 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 311403018354 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 311403018355 active site 311403018356 metal binding site [ion binding]; metal-binding site 311403018357 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403018358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403018359 Walker A/P-loop; other site 311403018360 ATP binding site [chemical binding]; other site 311403018361 Q-loop/lid; other site 311403018362 ABC transporter signature motif; other site 311403018363 Walker B; other site 311403018364 D-loop; other site 311403018365 H-loop/switch region; other site 311403018366 TOBE domain; Region: TOBE_2; pfam08402 311403018367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018368 dimer interface [polypeptide binding]; other site 311403018369 conserved gate region; other site 311403018370 putative PBP binding loops; other site 311403018371 ABC-ATPase subunit interface; other site 311403018372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403018373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403018374 dimer interface [polypeptide binding]; other site 311403018375 conserved gate region; other site 311403018376 putative PBP binding loops; other site 311403018377 ABC-ATPase subunit interface; other site 311403018378 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403018379 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403018380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403018381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403018382 DNA binding site [nucleotide binding] 311403018383 domain linker motif; other site 311403018384 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403018385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403018386 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403018387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403018388 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 311403018389 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403018390 MarR family; Region: MarR_2; pfam12802 311403018391 hypothetical protein; Provisional; Region: PRK07236 311403018392 FAD binding domain; Region: FAD_binding_3; pfam01494 311403018393 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403018394 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 311403018395 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 311403018396 dimer interface [polypeptide binding]; other site 311403018397 NADP binding site [chemical binding]; other site 311403018398 catalytic residues [active] 311403018399 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 311403018400 Mechanosensitive ion channel; Region: MS_channel; pfam00924 311403018401 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403018402 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403018403 ligand binding site [chemical binding]; other site 311403018404 flexible hinge region; other site 311403018405 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 311403018406 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 311403018407 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 311403018408 Isochorismatase family; Region: Isochorismatase; pfam00857 311403018409 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 311403018410 catalytic triad [active] 311403018411 conserved cis-peptide bond; other site 311403018412 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403018413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403018414 substrate binding pocket [chemical binding]; other site 311403018415 membrane-bound complex binding site; other site 311403018416 hinge residues; other site 311403018417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403018418 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403018419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403018420 non-specific DNA binding site [nucleotide binding]; other site 311403018421 salt bridge; other site 311403018422 sequence-specific DNA binding site [nucleotide binding]; other site 311403018423 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403018424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403018425 non-specific DNA binding site [nucleotide binding]; other site 311403018426 salt bridge; other site 311403018427 sequence-specific DNA binding site [nucleotide binding]; other site 311403018428 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403018429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403018430 sequence-specific DNA binding site [nucleotide binding]; other site 311403018431 salt bridge; other site 311403018432 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403018433 nucleotide binding region [chemical binding]; other site 311403018434 ATP-binding site [chemical binding]; other site 311403018435 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 311403018436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403018437 S-adenosylmethionine binding site [chemical binding]; other site 311403018438 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 311403018439 active site 311403018440 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403018441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403018442 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 311403018443 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403018444 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 311403018445 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 311403018446 Nuclease-related domain; Region: NERD; pfam08378 311403018447 Family description; Region: UvrD_C_2; pfam13538 311403018448 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 311403018449 AAA domain; Region: AAA_23; pfam13476 311403018450 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 311403018451 active site 311403018452 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403018453 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 311403018454 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 311403018455 Peptidase family M23; Region: Peptidase_M23; pfam01551 311403018456 Predicted kinase [General function prediction only]; Region: COG0645 311403018457 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 311403018458 active site 311403018459 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 311403018460 Clp amino terminal domain; Region: Clp_N; pfam02861 311403018461 Clp amino terminal domain; Region: Clp_N; pfam02861 311403018462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403018463 Walker A motif; other site 311403018464 ATP binding site [chemical binding]; other site 311403018465 Walker B motif; other site 311403018466 arginine finger; other site 311403018467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403018468 Walker A motif; other site 311403018469 ATP binding site [chemical binding]; other site 311403018470 Walker B motif; other site 311403018471 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 311403018472 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 311403018473 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 311403018474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 311403018475 S-adenosylmethionine binding site [chemical binding]; other site 311403018476 peptide chain release factor 1; Validated; Region: prfA; PRK00591 311403018477 This domain is found in peptide chain release factors; Region: PCRF; smart00937 311403018478 RF-1 domain; Region: RF-1; pfam00472 311403018479 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 311403018480 GAF domain; Region: GAF; pfam01590 311403018481 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 311403018482 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 311403018483 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 311403018484 aspartate kinase; Reviewed; Region: PRK06635 311403018485 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 311403018486 putative nucleotide binding site [chemical binding]; other site 311403018487 putative catalytic residues [active] 311403018488 putative Mg ion binding site [ion binding]; other site 311403018489 putative aspartate binding site [chemical binding]; other site 311403018490 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 311403018491 putative allosteric regulatory site; other site 311403018492 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 311403018493 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 311403018494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403018495 S-adenosylmethionine binding site [chemical binding]; other site 311403018496 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 311403018497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319 311403018498 nitrilase; Region: PLN02798 311403018499 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 311403018500 putative active site [active] 311403018501 catalytic triad [active] 311403018502 dimer interface [polypeptide binding]; other site 311403018503 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 311403018504 GSH binding site [chemical binding]; other site 311403018505 catalytic residues [active] 311403018506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 311403018507 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 311403018508 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 311403018509 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 311403018510 active site 311403018511 8-oxo-dGMP binding site [chemical binding]; other site 311403018512 nudix motif; other site 311403018513 metal binding site [ion binding]; metal-binding site 311403018514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403018515 Coenzyme A binding pocket [chemical binding]; other site 311403018516 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 311403018517 heterotetramer interface [polypeptide binding]; other site 311403018518 active site pocket [active] 311403018519 cleavage site 311403018520 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 311403018521 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 311403018522 DEAD/DEAH box helicase; Region: DEAD; pfam00270 311403018523 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 311403018524 SEC-C motif; Region: SEC-C; pfam02810 311403018525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403018526 LysR family transcriptional regulator; Provisional; Region: PRK14997 311403018527 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 311403018528 putative effector binding pocket; other site 311403018529 putative dimerization interface [polypeptide binding]; other site 311403018530 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 311403018531 active site 1 [active] 311403018532 dimer interface [polypeptide binding]; other site 311403018533 hexamer interface [polypeptide binding]; other site 311403018534 active site 2 [active] 311403018535 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403018536 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 311403018537 putative C-terminal domain interface [polypeptide binding]; other site 311403018538 putative GSH binding site (G-site) [chemical binding]; other site 311403018539 putative dimer interface [polypeptide binding]; other site 311403018540 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 311403018541 N-terminal domain interface [polypeptide binding]; other site 311403018542 dimer interface [polypeptide binding]; other site 311403018543 substrate binding pocket (H-site) [chemical binding]; other site 311403018544 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 311403018545 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 311403018546 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 311403018547 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 311403018548 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 311403018549 active site 311403018550 acyl-activating enzyme (AAE) consensus motif; other site 311403018551 putative CoA binding site [chemical binding]; other site 311403018552 AMP binding site [chemical binding]; other site 311403018553 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 311403018554 EamA-like transporter family; Region: EamA; cl17759 311403018555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403018556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403018557 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 311403018558 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 311403018559 Catalytic site [active] 311403018560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403018561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403018562 active site 311403018563 catalytic tetrad [active] 311403018564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403018565 S-adenosylmethionine binding site [chemical binding]; other site 311403018566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403018567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403018568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403018569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403018570 putative substrate translocation pore; other site 311403018571 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403018572 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403018573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403018574 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 311403018575 Predicted membrane protein [Function unknown]; Region: COG1238 311403018576 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 311403018577 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 311403018578 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 311403018579 active site 311403018580 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 311403018581 endonuclease III; Region: ENDO3c; smart00478 311403018582 minor groove reading motif; other site 311403018583 helix-hairpin-helix signature motif; other site 311403018584 substrate binding pocket [chemical binding]; other site 311403018585 active site 311403018586 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 311403018587 active site 311403018588 HIGH motif; other site 311403018589 nucleotide binding site [chemical binding]; other site 311403018590 active site 311403018591 KMSKS motif; other site 311403018592 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 311403018593 short chain dehydrogenase; Provisional; Region: PRK05993 311403018594 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 311403018595 NADP binding site [chemical binding]; other site 311403018596 active site 311403018597 steroid binding site; other site 311403018598 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 311403018599 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 311403018600 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 311403018601 Ligand binding site [chemical binding]; other site 311403018602 Electron transfer flavoprotein domain; Region: ETF; pfam01012 311403018603 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 311403018604 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 311403018605 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 311403018606 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 311403018607 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 311403018608 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 311403018609 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 311403018610 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 311403018611 catalytic residues [active] 311403018612 argininosuccinate lyase; Provisional; Region: PRK00855 311403018613 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 311403018614 active sites [active] 311403018615 tetramer interface [polypeptide binding]; other site 311403018616 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 311403018617 diaminopimelate decarboxylase; Region: lysA; TIGR01048 311403018618 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 311403018619 active site 311403018620 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 311403018621 substrate binding site [chemical binding]; other site 311403018622 catalytic residues [active] 311403018623 dimer interface [polypeptide binding]; other site 311403018624 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 311403018625 CHASE3 domain; Region: CHASE3; cl05000 311403018626 Response regulator receiver domain; Region: Response_reg; pfam00072 311403018627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403018628 active site 311403018629 phosphorylation site [posttranslational modification] 311403018630 intermolecular recognition site; other site 311403018631 dimerization interface [polypeptide binding]; other site 311403018632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 311403018633 active site 311403018634 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 311403018635 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 311403018636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 311403018637 Walker A/P-loop; other site 311403018638 ATP binding site [chemical binding]; other site 311403018639 Q-loop/lid; other site 311403018640 ABC transporter signature motif; other site 311403018641 Walker B; other site 311403018642 D-loop; other site 311403018643 H-loop/switch region; other site 311403018644 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 311403018645 Uncharacterized conserved protein [Function unknown]; Region: COG1434 311403018646 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 311403018647 putative active site [active] 311403018648 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 311403018649 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 311403018650 putative acyl-acceptor binding pocket; other site 311403018651 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 311403018652 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 311403018653 putative active site pocket [active] 311403018654 dimerization interface [polypeptide binding]; other site 311403018655 putative catalytic residue [active] 311403018656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 311403018657 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 311403018658 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 311403018659 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 311403018660 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 311403018661 prephenate dehydrogenase; Validated; Region: PRK08507 311403018662 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 311403018663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403018664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403018665 homodimer interface [polypeptide binding]; other site 311403018666 catalytic residue [active] 311403018667 Methyltransferase domain; Region: Methyltransf_23; pfam13489 311403018668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403018669 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 311403018670 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 311403018671 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 311403018672 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 311403018673 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 311403018674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 311403018675 EamA-like transporter family; Region: EamA; pfam00892 311403018676 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403018677 EamA-like transporter family; Region: EamA; pfam00892 311403018678 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 311403018679 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 311403018680 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 311403018681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 311403018682 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 311403018683 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 311403018684 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 311403018685 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 311403018686 metal ion-dependent adhesion site (MIDAS); other site 311403018687 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 311403018688 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 311403018689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 311403018690 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 311403018691 HSP70 interaction site [polypeptide binding]; other site 311403018692 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 311403018693 Domain of unknown function DUF21; Region: DUF21; pfam01595 311403018694 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 311403018695 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 311403018696 Transporter associated domain; Region: CorC_HlyC; smart01091 311403018697 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 311403018698 active site 311403018699 dimer interface [polypeptide binding]; other site 311403018700 metal binding site [ion binding]; metal-binding site 311403018701 shikimate kinase; Provisional; Region: PRK13946 311403018702 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 311403018703 ADP binding site [chemical binding]; other site 311403018704 magnesium binding site [ion binding]; other site 311403018705 putative shikimate binding site; other site 311403018706 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 311403018707 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403018708 active site 311403018709 DNA binding site [nucleotide binding] 311403018710 Int/Topo IB signature motif; other site 311403018711 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 311403018712 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 311403018713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 311403018714 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 311403018715 CPxP motif; other site 311403018716 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 311403018717 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 311403018718 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 311403018719 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 311403018720 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 311403018721 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 311403018722 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 311403018723 metal binding site [ion binding]; metal-binding site 311403018724 putative dimer interface [polypeptide binding]; other site 311403018725 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 311403018726 oligomerization interface [polypeptide binding]; other site 311403018727 Phage portal protein; Region: Phage_portal; pfam04860 311403018728 Phage-related protein [Function unknown]; Region: COG4695; cl01923 311403018729 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 311403018730 Phage capsid family; Region: Phage_capsid; pfam05065 311403018731 Phage terminase, small subunit; Region: Terminase_4; cl01525 311403018732 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 311403018733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403018734 AAA domain; Region: AAA_25; pfam13481 311403018735 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 311403018736 ATP binding site [chemical binding]; other site 311403018737 Walker A motif; other site 311403018738 Walker B motif; other site 311403018739 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 311403018740 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 311403018741 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403018742 active site 311403018743 DNA binding site [nucleotide binding] 311403018744 Int/Topo IB signature motif; other site 311403018745 topology modulation protein; Reviewed; Region: PRK08118 311403018746 AAA domain; Region: AAA_17; pfam13207 311403018747 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403018748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403018749 BON domain; Region: BON; pfam04972 311403018750 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 311403018751 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 311403018752 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 311403018753 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 311403018754 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 311403018755 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 311403018756 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 311403018757 substrate-cofactor binding pocket; other site 311403018758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403018759 catalytic residue [active] 311403018760 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 311403018761 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 311403018762 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 311403018763 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 311403018764 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403018765 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 311403018766 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 311403018767 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 311403018768 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 311403018769 Surface antigen; Region: Bac_surface_Ag; pfam01103 311403018770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 311403018771 Family of unknown function (DUF490); Region: DUF490; pfam04357 311403018772 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 311403018773 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403018774 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403018775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403018776 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403018777 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 311403018778 AsnC family; Region: AsnC_trans_reg; pfam01037 311403018779 Arginase family; Region: Arginase; cd09989 311403018780 active site 311403018781 Mn binding site [ion binding]; other site 311403018782 oligomer interface [polypeptide binding]; other site 311403018783 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 311403018784 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403018785 inhibitor-cofactor binding pocket; inhibition site 311403018786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403018787 catalytic residue [active] 311403018788 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 311403018789 putative CheA interaction surface; other site 311403018790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403018791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403018792 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 311403018793 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 311403018794 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 311403018795 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403018796 catalytic loop [active] 311403018797 iron binding site [ion binding]; other site 311403018798 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 311403018799 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 311403018800 [4Fe-4S] binding site [ion binding]; other site 311403018801 molybdopterin cofactor binding site; other site 311403018802 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 311403018803 molybdopterin cofactor binding site; other site 311403018804 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 311403018805 putative dimer interface [polypeptide binding]; other site 311403018806 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 311403018807 SLBB domain; Region: SLBB; pfam10531 311403018808 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 311403018809 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 311403018810 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 311403018811 putative dimer interface [polypeptide binding]; other site 311403018812 [2Fe-2S] cluster binding site [ion binding]; other site 311403018813 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403018814 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403018815 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403018816 dimerization interface [polypeptide binding]; other site 311403018817 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 311403018818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403018819 dimerization interface [polypeptide binding]; other site 311403018820 putative DNA binding site [nucleotide binding]; other site 311403018821 putative Zn2+ binding site [ion binding]; other site 311403018822 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 311403018823 classical (c) SDRs; Region: SDR_c; cd05233 311403018824 NAD(P) binding site [chemical binding]; other site 311403018825 active site 311403018826 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403018827 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 311403018828 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403018829 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 311403018830 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 311403018831 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 311403018832 DNA binding residues [nucleotide binding] 311403018833 dimer interface [polypeptide binding]; other site 311403018834 [2Fe-2S] cluster binding site [ion binding]; other site 311403018835 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403018836 Predicted flavoprotein [General function prediction only]; Region: COG0431 311403018837 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 311403018838 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403018839 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 311403018840 active site pocket [active] 311403018841 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403018842 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 311403018843 NAD(P) binding site [chemical binding]; other site 311403018844 catalytic residues [active] 311403018845 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 311403018846 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 311403018847 active site 311403018848 NAD binding site [chemical binding]; other site 311403018849 metal binding site [ion binding]; metal-binding site 311403018850 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 311403018851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403018852 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403018853 dimerization interface [polypeptide binding]; other site 311403018854 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 311403018855 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 311403018856 gamma subunit interface [polypeptide binding]; other site 311403018857 epsilon subunit interface [polypeptide binding]; other site 311403018858 LBP interface [polypeptide binding]; other site 311403018859 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 311403018860 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 311403018861 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 311403018862 alpha subunit interaction interface [polypeptide binding]; other site 311403018863 Walker A motif; other site 311403018864 ATP binding site [chemical binding]; other site 311403018865 Walker B motif; other site 311403018866 inhibitor binding site; inhibition site 311403018867 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 311403018868 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 311403018869 core domain interface [polypeptide binding]; other site 311403018870 delta subunit interface [polypeptide binding]; other site 311403018871 epsilon subunit interface [polypeptide binding]; other site 311403018872 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 311403018873 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 311403018874 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 311403018875 beta subunit interaction interface [polypeptide binding]; other site 311403018876 Walker A motif; other site 311403018877 ATP binding site [chemical binding]; other site 311403018878 Walker B motif; other site 311403018879 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 311403018880 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 311403018881 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 311403018882 Protein of unknown function (DUF3620); Region: DUF3620; pfam12281 311403018883 primosome assembly protein PriA; Validated; Region: PRK05580 311403018884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403018885 ATP binding site [chemical binding]; other site 311403018886 putative Mg++ binding site [ion binding]; other site 311403018887 helicase superfamily c-terminal domain; Region: HELICc; smart00490 311403018888 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 311403018889 Active site serine [active] 311403018890 uridine kinase; Validated; Region: PRK06696 311403018891 active site 311403018892 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 311403018893 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 311403018894 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 311403018895 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 311403018896 active site 311403018897 DNA binding site [nucleotide binding] 311403018898 Int/Topo IB signature motif; other site 311403018899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 311403018900 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 311403018901 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 311403018902 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 311403018903 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 311403018904 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 311403018905 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 311403018906 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 311403018907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 311403018908 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 311403018909 LysE type translocator; Region: LysE; cl00565 311403018910 short chain dehydrogenase; Provisional; Region: PRK06123 311403018911 classical (c) SDRs; Region: SDR_c; cd05233 311403018912 NAD(P) binding site [chemical binding]; other site 311403018913 active site 311403018914 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 311403018915 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 311403018916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 311403018917 E3 interaction surface; other site 311403018918 lipoyl attachment site [posttranslational modification]; other site 311403018919 e3 binding domain; Region: E3_binding; pfam02817 311403018920 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 311403018921 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 311403018922 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 311403018923 TPP-binding site [chemical binding]; other site 311403018924 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 311403018925 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 311403018926 CoA binding domain; Region: CoA_binding; smart00881 311403018927 CoA-ligase; Region: Ligase_CoA; pfam00549 311403018928 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 311403018929 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 311403018930 CoA-ligase; Region: Ligase_CoA; pfam00549 311403018931 malate dehydrogenase; Reviewed; Region: PRK06223 311403018932 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 311403018933 NAD(P) binding site [chemical binding]; other site 311403018934 dimer interface [polypeptide binding]; other site 311403018935 tetramer (dimer of dimers) interface [polypeptide binding]; other site 311403018936 substrate binding site [chemical binding]; other site 311403018937 Predicted ATPase [General function prediction only]; Region: COG1485 311403018938 Protease inhibitor Inh; Region: Inh; pfam02974 311403018939 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 311403018940 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 311403018941 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 311403018942 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 311403018943 L-aspartate oxidase; Provisional; Region: PRK06175 311403018944 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 311403018945 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 311403018946 putative SdhC subunit interface [polypeptide binding]; other site 311403018947 putative proximal heme binding site [chemical binding]; other site 311403018948 putative Iron-sulfur protein interface [polypeptide binding]; other site 311403018949 putative proximal quinone binding site; other site 311403018950 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 311403018951 Iron-sulfur protein interface; other site 311403018952 proximal quinone binding site [chemical binding]; other site 311403018953 SdhD (CybS) interface [polypeptide binding]; other site 311403018954 proximal heme binding site [chemical binding]; other site 311403018955 Predicted methyltransferase [General function prediction only]; Region: COG3897 311403018956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 311403018957 EVE domain; Region: EVE; cl00728 311403018958 YciI-like protein; Reviewed; Region: PRK12865 311403018959 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 311403018960 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 311403018961 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 311403018962 UGMP family protein; Validated; Region: PRK09604 311403018963 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 311403018964 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 311403018965 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 311403018966 domain interfaces; other site 311403018967 active site 311403018968 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 311403018969 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 311403018970 active site 311403018971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 311403018972 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 311403018973 HemY protein N-terminus; Region: HemY_N; pfam07219 311403018974 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 311403018975 putative metal binding site [ion binding]; other site 311403018976 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 311403018977 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 311403018978 catalytic triad [active] 311403018979 Protein of unknown function (DUF867); Region: DUF867; pfam05908 311403018980 H+ Antiporter protein; Region: 2A0121; TIGR00900 311403018981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403018982 putative substrate translocation pore; other site 311403018983 YGGT family; Region: YGGT; pfam02325 311403018984 hypothetical protein; Validated; Region: PRK01310 311403018985 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 311403018986 substrate binding site [chemical binding]; other site 311403018987 metal binding sites [ion binding]; metal-binding site 311403018988 dimer interface [polypeptide binding]; other site 311403018989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403018990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403018991 Coenzyme A binding pocket [chemical binding]; other site 311403018992 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 311403018993 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 311403018994 G1 box; other site 311403018995 putative GEF interaction site [polypeptide binding]; other site 311403018996 GTP/Mg2+ binding site [chemical binding]; other site 311403018997 Switch I region; other site 311403018998 G2 box; other site 311403018999 G3 box; other site 311403019000 Switch II region; other site 311403019001 G4 box; other site 311403019002 G5 box; other site 311403019003 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 311403019004 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 311403019005 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 311403019006 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 311403019007 active site 311403019008 Zn binding site [ion binding]; other site 311403019009 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403019010 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403019011 MarR family; Region: MarR_2; pfam12802 311403019012 argininosuccinate synthase; Provisional; Region: PRK13820 311403019013 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 311403019014 ANP binding site [chemical binding]; other site 311403019015 Substrate Binding Site II [chemical binding]; other site 311403019016 Substrate Binding Site I [chemical binding]; other site 311403019017 hypothetical protein; Provisional; Region: PRK06194 311403019018 classical (c) SDRs; Region: SDR_c; cd05233 311403019019 NAD(P) binding site [chemical binding]; other site 311403019020 active site 311403019021 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403019022 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 311403019023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403019024 FeS/SAM binding site; other site 311403019025 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 311403019026 Uncharacterized conserved protein [Function unknown]; Region: COG3339 311403019027 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 311403019028 aromatic arch; other site 311403019029 DCoH dimer interaction site [polypeptide binding]; other site 311403019030 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 311403019031 DCoH tetramer interaction site [polypeptide binding]; other site 311403019032 substrate binding site [chemical binding]; other site 311403019033 Low molecular weight phosphatase family; Region: LMWPc; cd00115 311403019034 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 311403019035 active site 311403019036 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 311403019037 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 311403019038 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 311403019039 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 311403019040 active site 311403019041 catalytic triad [active] 311403019042 oxyanion hole [active] 311403019043 switch loop; other site 311403019044 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 311403019045 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 311403019046 Walker A/P-loop; other site 311403019047 ATP binding site [chemical binding]; other site 311403019048 Q-loop/lid; other site 311403019049 ABC transporter signature motif; other site 311403019050 Walker B; other site 311403019051 D-loop; other site 311403019052 H-loop/switch region; other site 311403019053 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 311403019054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 311403019055 FtsX-like permease family; Region: FtsX; pfam02687 311403019056 FtsX-like permease family; Region: FtsX; pfam02687 311403019057 ybhL leader; predicted by Infernal 311403019058 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 311403019059 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 311403019060 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 311403019061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403019062 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 311403019063 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 311403019064 Uncharacterized secreted protein [Function unknown]; Region: COG5429 311403019065 aconitate hydratase; Validated; Region: PRK09277 311403019066 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 311403019067 substrate binding site [chemical binding]; other site 311403019068 ligand binding site [chemical binding]; other site 311403019069 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 311403019070 substrate binding site [chemical binding]; other site 311403019071 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 311403019072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403019073 Walker A/P-loop; other site 311403019074 ATP binding site [chemical binding]; other site 311403019075 Q-loop/lid; other site 311403019076 ABC transporter signature motif; other site 311403019077 Walker B; other site 311403019078 D-loop; other site 311403019079 H-loop/switch region; other site 311403019080 heme exporter protein CcmB; Region: ccmB; TIGR01190 311403019081 heme exporter protein CcmC; Region: ccmC; TIGR01191 311403019082 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 311403019083 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 311403019084 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 311403019085 catalytic residues [active] 311403019086 central insert; other site 311403019087 hypothetical protein; Provisional; Region: PRK00944 311403019088 intracellular septation protein A; Reviewed; Region: PRK00259 311403019089 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 311403019090 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 311403019091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 311403019092 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 311403019093 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 311403019094 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403019095 FeS/SAM binding site; other site 311403019096 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 311403019097 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 311403019098 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 311403019099 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 311403019100 putative hydrophobic ligand binding site [chemical binding]; other site 311403019101 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 311403019102 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 311403019103 signal recognition particle protein; Provisional; Region: PRK10867 311403019104 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 311403019105 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 311403019106 P loop; other site 311403019107 GTP binding site [chemical binding]; other site 311403019108 Signal peptide binding domain; Region: SRP_SPB; pfam02978 311403019109 chorismate mutase; Provisional; Region: PRK09239 311403019110 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 311403019111 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 311403019112 RimM N-terminal domain; Region: RimM; pfam01782 311403019113 PRC-barrel domain; Region: PRC; pfam05239 311403019114 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 311403019115 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 311403019116 active site 311403019117 ATP binding site [chemical binding]; other site 311403019118 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 311403019119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403019120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403019121 WHG domain; Region: WHG; pfam13305 311403019122 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403019123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403019124 putative DNA binding site [nucleotide binding]; other site 311403019125 putative Zn2+ binding site [ion binding]; other site 311403019126 AsnC family; Region: AsnC_trans_reg; pfam01037 311403019127 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 311403019128 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 311403019129 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 311403019130 catalytic residue [active] 311403019131 maltose O-acetyltransferase; Provisional; Region: PRK10092 311403019132 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 311403019133 active site 311403019134 substrate binding site [chemical binding]; other site 311403019135 trimer interface [polypeptide binding]; other site 311403019136 CoA binding site [chemical binding]; other site 311403019137 ornithine carbamoyltransferase; Provisional; Region: PRK00779 311403019138 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 311403019139 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 311403019140 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 311403019141 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403019142 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403019143 substrate binding pocket [chemical binding]; other site 311403019144 membrane-bound complex binding site; other site 311403019145 hinge residues; other site 311403019146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019147 dimer interface [polypeptide binding]; other site 311403019148 conserved gate region; other site 311403019149 putative PBP binding loops; other site 311403019150 ABC-ATPase subunit interface; other site 311403019151 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 311403019152 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 311403019153 substrate binding site [chemical binding]; other site 311403019154 ligand binding site [chemical binding]; other site 311403019155 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 311403019156 EamA-like transporter family; Region: EamA; pfam00892 311403019157 EamA-like transporter family; Region: EamA; pfam00892 311403019158 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403019159 MarR family; Region: MarR; pfam01047 311403019160 transcriptional regulator; Provisional; Region: PRK10632 311403019161 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403019162 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 311403019163 putative effector binding pocket; other site 311403019164 putative dimerization interface [polypeptide binding]; other site 311403019165 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 311403019166 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 311403019167 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 311403019168 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 311403019169 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 311403019170 active site 311403019171 catalytic tetrad [active] 311403019172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 311403019173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403019174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403019175 active site 311403019176 phosphorylation site [posttranslational modification] 311403019177 intermolecular recognition site; other site 311403019178 dimerization interface [polypeptide binding]; other site 311403019179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403019180 DNA binding site [nucleotide binding] 311403019181 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 311403019182 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 311403019183 ligand binding site [chemical binding]; other site 311403019184 flexible hinge region; other site 311403019185 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 311403019186 putative catalytic site [active] 311403019187 putative phosphate binding site [ion binding]; other site 311403019188 active site 311403019189 metal binding site A [ion binding]; metal-binding site 311403019190 DNA binding site [nucleotide binding] 311403019191 putative AP binding site [nucleotide binding]; other site 311403019192 putative metal binding site B [ion binding]; other site 311403019193 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 311403019194 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 311403019195 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 311403019196 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 311403019197 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 311403019198 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 311403019199 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 311403019200 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 311403019201 Nitrogen regulatory protein P-II; Region: P-II; smart00938 311403019202 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 311403019203 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 311403019204 active site 311403019205 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 311403019206 catalytic triad [active] 311403019207 dimer interface [polypeptide binding]; other site 311403019208 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 311403019209 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 311403019210 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403019211 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403019212 DoxX-like family; Region: DoxX_2; pfam13564 311403019213 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403019214 classical (c) SDRs; Region: SDR_c; cd05233 311403019215 NAD(P) binding site [chemical binding]; other site 311403019216 active site 311403019217 Uncharacterized conserved protein [Function unknown]; Region: COG2835 311403019218 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 311403019219 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 311403019220 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 311403019221 catalytic residues [active] 311403019222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 311403019223 binding surface 311403019224 TPR motif; other site 311403019225 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 311403019226 putative deacylase active site [active] 311403019227 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403019228 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403019229 Walker A/P-loop; other site 311403019230 ATP binding site [chemical binding]; other site 311403019231 Q-loop/lid; other site 311403019232 ABC transporter signature motif; other site 311403019233 Walker B; other site 311403019234 D-loop; other site 311403019235 H-loop/switch region; other site 311403019236 TOBE domain; Region: TOBE_2; pfam08402 311403019237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403019238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019239 dimer interface [polypeptide binding]; other site 311403019240 conserved gate region; other site 311403019241 putative PBP binding loops; other site 311403019242 ABC-ATPase subunit interface; other site 311403019243 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 311403019244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019245 putative PBP binding loops; other site 311403019246 ABC-ATPase subunit interface; other site 311403019247 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403019248 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403019249 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 311403019250 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 311403019251 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403019252 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403019253 DNA binding site [nucleotide binding] 311403019254 domain linker motif; other site 311403019255 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403019256 dimerization interface [polypeptide binding]; other site 311403019257 ligand binding site [chemical binding]; other site 311403019258 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 311403019259 nucleophile elbow; other site 311403019260 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403019261 Protein export membrane protein; Region: SecD_SecF; cl14618 311403019262 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403019263 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403019264 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403019265 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403019266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403019267 active site 311403019268 phosphorylation site [posttranslational modification] 311403019269 intermolecular recognition site; other site 311403019270 dimerization interface [polypeptide binding]; other site 311403019271 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403019272 DNA binding site [nucleotide binding] 311403019273 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403019274 HAMP domain; Region: HAMP; pfam00672 311403019275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403019276 dimer interface [polypeptide binding]; other site 311403019277 phosphorylation site [posttranslational modification] 311403019278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403019279 ATP binding site [chemical binding]; other site 311403019280 Mg2+ binding site [ion binding]; other site 311403019281 G-X-G motif; other site 311403019282 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 311403019283 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 311403019284 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 311403019285 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 311403019286 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 311403019287 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403019288 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 311403019289 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 311403019290 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 311403019291 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 311403019292 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403019293 NAD binding site [chemical binding]; other site 311403019294 catalytic residues [active] 311403019295 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 311403019296 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 311403019297 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 311403019298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403019299 S-adenosylmethionine binding site [chemical binding]; other site 311403019300 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 311403019301 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 311403019302 Esterase/lipase [General function prediction only]; Region: COG1647 311403019303 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 311403019304 Fatty acid desaturase; Region: FA_desaturase; pfam00487 311403019305 putative di-iron ligands [ion binding]; other site 311403019306 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 311403019307 active site 311403019308 metal binding site [ion binding]; metal-binding site 311403019309 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 311403019310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403019311 inhibitor-cofactor binding pocket; inhibition site 311403019312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403019313 catalytic residue [active] 311403019314 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 311403019315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 311403019316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403019317 dimer interface [polypeptide binding]; other site 311403019318 phosphorylation site [posttranslational modification] 311403019319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403019320 ATP binding site [chemical binding]; other site 311403019321 Mg2+ binding site [ion binding]; other site 311403019322 G-X-G motif; other site 311403019323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 311403019324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403019325 active site 311403019326 phosphorylation site [posttranslational modification] 311403019327 intermolecular recognition site; other site 311403019328 dimerization interface [polypeptide binding]; other site 311403019329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403019330 DNA binding site [nucleotide binding] 311403019331 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 311403019332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 311403019333 active site 311403019334 benzoate transport; Region: 2A0115; TIGR00895 311403019335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403019336 putative substrate translocation pore; other site 311403019337 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 311403019338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403019339 DNA-binding site [nucleotide binding]; DNA binding site 311403019340 UTRA domain; Region: UTRA; pfam07702 311403019341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403019342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403019343 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 311403019344 putative dimerization interface [polypeptide binding]; other site 311403019345 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 311403019346 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403019347 putative metal binding site [ion binding]; other site 311403019348 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 311403019349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403019350 DNA-binding site [nucleotide binding]; DNA binding site 311403019351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 311403019352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403019353 homodimer interface [polypeptide binding]; other site 311403019354 catalytic residue [active] 311403019355 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 311403019356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 311403019357 SnoaL-like domain; Region: SnoaL_2; pfam12680 311403019358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403019359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403019360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 311403019361 Putative glucoamylase; Region: Glycoamylase; pfam10091 311403019362 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403019363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403019364 putative DNA binding site [nucleotide binding]; other site 311403019365 putative Zn2+ binding site [ion binding]; other site 311403019366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403019367 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 311403019368 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 311403019369 AsnC family; Region: AsnC_trans_reg; pfam01037 311403019370 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 311403019371 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403019372 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403019373 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 311403019374 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 311403019375 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 311403019376 Probable Catalytic site; other site 311403019377 metal-binding site 311403019378 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 311403019379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 311403019380 active site 311403019381 phosphorylation site [posttranslational modification] 311403019382 intermolecular recognition site; other site 311403019383 dimerization interface [polypeptide binding]; other site 311403019384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 311403019385 DNA binding site [nucleotide binding] 311403019386 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 311403019387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 311403019388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 311403019389 dimer interface [polypeptide binding]; other site 311403019390 phosphorylation site [posttranslational modification] 311403019391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 311403019392 ATP binding site [chemical binding]; other site 311403019393 Mg2+ binding site [ion binding]; other site 311403019394 G-X-G motif; other site 311403019395 replicative DNA helicase; Provisional; Region: PRK05973 311403019396 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 311403019397 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403019398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019399 dimer interface [polypeptide binding]; other site 311403019400 conserved gate region; other site 311403019401 putative PBP binding loops; other site 311403019402 ABC-ATPase subunit interface; other site 311403019403 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403019404 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403019405 Walker A/P-loop; other site 311403019406 ATP binding site [chemical binding]; other site 311403019407 Q-loop/lid; other site 311403019408 ABC transporter signature motif; other site 311403019409 Walker B; other site 311403019410 D-loop; other site 311403019411 H-loop/switch region; other site 311403019412 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403019413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 311403019414 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403019415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403019416 non-specific DNA binding site [nucleotide binding]; other site 311403019417 salt bridge; other site 311403019418 sequence-specific DNA binding site [nucleotide binding]; other site 311403019419 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 311403019420 Predicted integral membrane protein [Function unknown]; Region: COG5616 311403019421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 311403019422 TPR repeat; Region: TPR_11; pfam13414 311403019423 binding surface 311403019424 TPR motif; other site 311403019425 Uncharacterized conserved protein [Function unknown]; Region: COG1944 311403019426 YcaO-like family; Region: YcaO; pfam02624 311403019427 TfuA-like protein; Region: TfuA; pfam07812 311403019428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403019429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403019430 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 311403019431 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403019432 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403019433 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 311403019434 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 311403019435 Protein export membrane protein; Region: SecD_SecF; cl14618 311403019436 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 311403019437 Protein export membrane protein; Region: SecD_SecF; cl14618 311403019438 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403019439 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 311403019440 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403019441 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 311403019442 HTH DNA binding domain; Region: HTH_13; pfam11972 311403019443 YHS domain; Region: YHS; pfam04945 311403019444 YHS domain; Region: YHS; pfam04945 311403019445 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 311403019446 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 311403019447 Soluble P-type ATPase [General function prediction only]; Region: COG4087 311403019448 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 311403019449 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 311403019450 DNA binding residues [nucleotide binding] 311403019451 dimer interface [polypeptide binding]; other site 311403019452 copper binding site [ion binding]; other site 311403019453 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 311403019454 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 311403019455 dimer interface [polypeptide binding]; other site 311403019456 active site 311403019457 Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704 311403019458 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 311403019459 putative active site [active] 311403019460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403019461 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403019462 putative substrate translocation pore; other site 311403019463 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 311403019464 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 311403019465 Moco binding site; other site 311403019466 metal coordination site [ion binding]; other site 311403019467 HutD; Region: HutD; pfam05962 311403019468 urocanate hydratase; Provisional; Region: PRK05414 311403019469 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 311403019470 active sites [active] 311403019471 tetramer interface [polypeptide binding]; other site 311403019472 imidazolonepropionase; Validated; Region: PRK09356 311403019473 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 311403019474 active site 311403019475 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 311403019476 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 311403019477 active site 311403019478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403019479 DNA-binding site [nucleotide binding]; DNA binding site 311403019480 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 311403019481 UTRA domain; Region: UTRA; pfam07702 311403019482 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 311403019483 active sites [active] 311403019484 tetramer interface [polypeptide binding]; other site 311403019485 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 311403019486 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 311403019487 Protein export membrane protein; Region: SecD_SecF; cl14618 311403019488 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403019489 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403019490 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403019491 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 311403019492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403019493 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 311403019494 manganese transport regulator MntR; Provisional; Region: PRK11050 311403019495 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 311403019496 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 311403019497 manganese transport protein MntH; Reviewed; Region: PRK00701 311403019498 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 311403019499 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 311403019500 Peptidase family M23; Region: Peptidase_M23; pfam01551 311403019501 prevent-host-death family protein; Region: phd_fam; TIGR01552 311403019502 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 311403019503 oligomeric interface; other site 311403019504 putative active site [active] 311403019505 homodimer interface [polypeptide binding]; other site 311403019506 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 311403019507 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 311403019508 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 311403019509 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 311403019510 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 311403019511 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 311403019512 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403019513 catalytic loop [active] 311403019514 iron binding site [ion binding]; other site 311403019515 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 311403019516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403019517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403019518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 311403019519 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403019520 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403019521 Walker A/P-loop; other site 311403019522 ATP binding site [chemical binding]; other site 311403019523 Q-loop/lid; other site 311403019524 ABC transporter signature motif; other site 311403019525 Walker B; other site 311403019526 D-loop; other site 311403019527 H-loop/switch region; other site 311403019528 TOBE domain; Region: TOBE_2; pfam08402 311403019529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403019530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019531 dimer interface [polypeptide binding]; other site 311403019532 conserved gate region; other site 311403019533 putative PBP binding loops; other site 311403019534 ABC-ATPase subunit interface; other site 311403019535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019536 dimer interface [polypeptide binding]; other site 311403019537 conserved gate region; other site 311403019538 putative PBP binding loops; other site 311403019539 ABC-ATPase subunit interface; other site 311403019540 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403019541 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403019542 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403019543 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403019544 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403019545 nucleotide binding site [chemical binding]; other site 311403019546 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403019547 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403019548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828 311403019549 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 311403019550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403019551 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 311403019552 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 311403019553 Cl binding site [ion binding]; other site 311403019554 oligomer interface [polypeptide binding]; other site 311403019555 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403019556 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 311403019557 Walker A/P-loop; other site 311403019558 ATP binding site [chemical binding]; other site 311403019559 Q-loop/lid; other site 311403019560 ABC transporter signature motif; other site 311403019561 Walker B; other site 311403019562 D-loop; other site 311403019563 H-loop/switch region; other site 311403019564 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403019565 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 311403019566 Walker A/P-loop; other site 311403019567 ATP binding site [chemical binding]; other site 311403019568 Q-loop/lid; other site 311403019569 ABC transporter signature motif; other site 311403019570 Walker B; other site 311403019571 D-loop; other site 311403019572 H-loop/switch region; other site 311403019573 TOBE domain; Region: TOBE_2; pfam08402 311403019574 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 311403019575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019576 dimer interface [polypeptide binding]; other site 311403019577 conserved gate region; other site 311403019578 putative PBP binding loops; other site 311403019579 ABC-ATPase subunit interface; other site 311403019580 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403019581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019582 dimer interface [polypeptide binding]; other site 311403019583 conserved gate region; other site 311403019584 putative PBP binding loops; other site 311403019585 ABC-ATPase subunit interface; other site 311403019586 Predicted small integral membrane protein (DUF2160); Region: DUF2160; cl02294 311403019587 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403019588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403019589 active site 311403019590 motif I; other site 311403019591 motif II; other site 311403019592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403019593 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403019594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403019595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403019596 DNA binding site [nucleotide binding] 311403019597 domain linker motif; other site 311403019598 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 311403019599 ligand binding site [chemical binding]; other site 311403019600 dimerization interface [polypeptide binding]; other site 311403019601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289 311403019602 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 311403019603 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 311403019604 putative ligand binding site [chemical binding]; other site 311403019605 putative NAD binding site [chemical binding]; other site 311403019606 catalytic site [active] 311403019607 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403019608 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403019609 catalytic residue [active] 311403019610 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403019611 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cd00636 311403019612 intersubunit interface [polypeptide binding]; other site 311403019613 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403019614 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; Region: MR_MLE; smart00922 311403019615 metal binding site [ion binding]; metal-binding site 311403019616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403019617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403019618 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403019619 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403019620 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403019621 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403019622 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 311403019623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019624 putative PBP binding loops; other site 311403019625 ABC-ATPase subunit interface; other site 311403019626 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403019627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019628 dimer interface [polypeptide binding]; other site 311403019629 conserved gate region; other site 311403019630 putative PBP binding loops; other site 311403019631 ABC-ATPase subunit interface; other site 311403019632 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403019633 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403019634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 311403019635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 311403019636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 311403019637 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 311403019638 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403019639 Walker A/P-loop; other site 311403019640 ATP binding site [chemical binding]; other site 311403019641 Q-loop/lid; other site 311403019642 ABC transporter signature motif; other site 311403019643 Walker B; other site 311403019644 D-loop; other site 311403019645 H-loop/switch region; other site 311403019646 TOBE domain; Region: TOBE_2; pfam08402 311403019647 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 311403019648 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 311403019649 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 311403019650 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 311403019651 dimer interface [polypeptide binding]; other site 311403019652 motif 1; other site 311403019653 active site 311403019654 motif 2; other site 311403019655 motif 3; other site 311403019656 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403019657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403019658 active site 311403019659 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403019660 active site 311403019661 acyl carrier protein; Provisional; Region: PRK07081 311403019662 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 311403019663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403019664 FeS/SAM binding site; other site 311403019665 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 311403019666 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 311403019667 motif 1; other site 311403019668 dimer interface [polypeptide binding]; other site 311403019669 active site 311403019670 motif 2; other site 311403019671 motif 3; other site 311403019672 elongation factor P; Validated; Region: PRK00529 311403019673 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 311403019674 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 311403019675 RNA binding site [nucleotide binding]; other site 311403019676 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 311403019677 RNA binding site [nucleotide binding]; other site 311403019678 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 311403019679 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 311403019680 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 311403019681 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 311403019682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403019683 Walker A motif; other site 311403019684 ATP binding site [chemical binding]; other site 311403019685 Walker B motif; other site 311403019686 arginine finger; other site 311403019687 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 311403019688 nudix motif; other site 311403019689 homoserine O-succinyltransferase; Provisional; Region: PRK05368 311403019690 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 311403019691 proposed active site lysine [active] 311403019692 conserved cys residue [active] 311403019693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 311403019694 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 311403019695 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403019696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403019697 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 311403019698 active site 311403019699 catalytic residues [active] 311403019700 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 311403019701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403019702 DNA-binding site [nucleotide binding]; DNA binding site 311403019703 UTRA domain; Region: UTRA; pfam07702 311403019704 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 311403019705 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 311403019706 dimer interface [polypeptide binding]; other site 311403019707 active site 311403019708 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 311403019709 dimer interface [polypeptide binding]; other site 311403019710 active site 311403019711 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 311403019712 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 311403019713 active site 311403019714 dimer interface [polypeptide binding]; other site 311403019715 hypothetical protein; Provisional; Region: PRK02947 311403019716 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 311403019717 putative active site [active] 311403019718 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 311403019719 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 311403019720 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403019721 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403019722 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 311403019723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403019724 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403019725 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 311403019726 Thiamine pyrophosphokinase; Region: TPK; cd07995 311403019727 active site 311403019728 dimerization interface [polypeptide binding]; other site 311403019729 thiamine binding site [chemical binding]; other site 311403019730 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 311403019731 MarR family; Region: MarR_2; pfam12802 311403019732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403019733 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403019734 putative substrate translocation pore; other site 311403019735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403019736 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 311403019737 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 311403019738 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 311403019739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019740 putative PBP binding loops; other site 311403019741 dimer interface [polypeptide binding]; other site 311403019742 ABC-ATPase subunit interface; other site 311403019743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019744 putative PBP binding loops; other site 311403019745 dimer interface [polypeptide binding]; other site 311403019746 ABC-ATPase subunit interface; other site 311403019747 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 311403019748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403019749 Walker A/P-loop; other site 311403019750 ATP binding site [chemical binding]; other site 311403019751 Q-loop/lid; other site 311403019752 ABC transporter signature motif; other site 311403019753 Walker B; other site 311403019754 D-loop; other site 311403019755 H-loop/switch region; other site 311403019756 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 311403019757 Peptidase family M48; Region: Peptidase_M48; pfam01435 311403019758 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 311403019759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403019760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403019761 DNA binding residues [nucleotide binding] 311403019762 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 311403019763 Ferredoxin [Energy production and conversion]; Region: COG1146 311403019764 4Fe-4S binding domain; Region: Fer4; cl02805 311403019765 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 311403019766 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 311403019767 RNA binding surface [nucleotide binding]; other site 311403019768 DEAD/DEAH box helicase; Region: DEAD; pfam00270 311403019769 ATP binding site [chemical binding]; other site 311403019770 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 311403019771 putative Mg++ binding site [ion binding]; other site 311403019772 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 311403019773 nucleotide binding region [chemical binding]; other site 311403019774 ATP-binding site [chemical binding]; other site 311403019775 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 311403019776 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 311403019777 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 311403019778 NAD(P) binding site [chemical binding]; other site 311403019779 homotetramer interface [polypeptide binding]; other site 311403019780 homodimer interface [polypeptide binding]; other site 311403019781 active site 311403019782 putative acyltransferase; Provisional; Region: PRK05790 311403019783 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 311403019784 dimer interface [polypeptide binding]; other site 311403019785 active site 311403019786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 311403019787 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 311403019788 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 311403019789 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 311403019790 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403019791 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 311403019792 putative C-terminal domain interface [polypeptide binding]; other site 311403019793 putative GSH binding site (G-site) [chemical binding]; other site 311403019794 putative dimer interface [polypeptide binding]; other site 311403019795 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 311403019796 putative N-terminal domain interface [polypeptide binding]; other site 311403019797 putative dimer interface [polypeptide binding]; other site 311403019798 putative substrate binding pocket (H-site) [chemical binding]; other site 311403019799 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 311403019800 Transglycosylase; Region: Transgly; cl17702 311403019801 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 311403019802 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 311403019803 substrate binding pocket [chemical binding]; other site 311403019804 chain length determination region; other site 311403019805 substrate-Mg2+ binding site; other site 311403019806 catalytic residues [active] 311403019807 aspartate-rich region 1; other site 311403019808 active site lid residues [active] 311403019809 aspartate-rich region 2; other site 311403019810 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403019811 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 311403019812 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 311403019813 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 311403019814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403019815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403019816 putative substrate translocation pore; other site 311403019817 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403019818 EamA-like transporter family; Region: EamA; pfam00892 311403019819 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403019820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403019821 putative substrate translocation pore; other site 311403019822 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 311403019823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403019824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403019825 dimerization interface [polypeptide binding]; other site 311403019826 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 311403019827 short chain dehydrogenase; Provisional; Region: PRK07041 311403019828 putative NAD(P) binding site [chemical binding]; other site 311403019829 homodimer interface [polypeptide binding]; other site 311403019830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403019831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403019832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 311403019833 dimerization interface [polypeptide binding]; other site 311403019834 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 311403019835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403019836 dimerization interface [polypeptide binding]; other site 311403019837 putative DNA binding site [nucleotide binding]; other site 311403019838 putative Zn2+ binding site [ion binding]; other site 311403019839 hydrophobic ligand binding site; other site 311403019840 Uncharacterized conserved protein [Function unknown]; Region: COG3832 311403019841 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 311403019842 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 311403019843 oligomer interface [polypeptide binding]; other site 311403019844 active site residues [active] 311403019845 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403019846 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403019847 substrate binding pocket [chemical binding]; other site 311403019848 membrane-bound complex binding site; other site 311403019849 hinge residues; other site 311403019850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019851 dimer interface [polypeptide binding]; other site 311403019852 conserved gate region; other site 311403019853 putative PBP binding loops; other site 311403019854 ABC-ATPase subunit interface; other site 311403019855 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403019856 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403019857 Walker A/P-loop; other site 311403019858 ATP binding site [chemical binding]; other site 311403019859 Q-loop/lid; other site 311403019860 ABC transporter signature motif; other site 311403019861 Walker B; other site 311403019862 D-loop; other site 311403019863 H-loop/switch region; other site 311403019864 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 311403019865 active site 311403019866 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 311403019867 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 311403019868 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 311403019869 HlyD family secretion protein; Region: HlyD_3; pfam13437 311403019870 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 311403019871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403019872 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 311403019873 Walker A/P-loop; other site 311403019874 ATP binding site [chemical binding]; other site 311403019875 Q-loop/lid; other site 311403019876 ABC transporter signature motif; other site 311403019877 Walker B; other site 311403019878 D-loop; other site 311403019879 H-loop/switch region; other site 311403019880 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 311403019881 pyruvate carboxylase; Reviewed; Region: PRK12999 311403019882 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 311403019883 ATP-grasp domain; Region: ATP-grasp_4; cl17255 311403019884 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 311403019885 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 311403019886 active site 311403019887 catalytic residues [active] 311403019888 metal binding site [ion binding]; metal-binding site 311403019889 homodimer binding site [polypeptide binding]; other site 311403019890 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 311403019891 carboxyltransferase (CT) interaction site; other site 311403019892 biotinylation site [posttranslational modification]; other site 311403019893 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 311403019894 Autoinducer binding domain; Region: Autoind_bind; pfam03472 311403019895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403019896 DNA binding residues [nucleotide binding] 311403019897 dimerization interface [polypeptide binding]; other site 311403019898 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 311403019899 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403019900 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 311403019901 Walker A/P-loop; other site 311403019902 ATP binding site [chemical binding]; other site 311403019903 Q-loop/lid; other site 311403019904 ABC transporter signature motif; other site 311403019905 Walker B; other site 311403019906 D-loop; other site 311403019907 H-loop/switch region; other site 311403019908 Porin subfamily; Region: Porin_2; pfam02530 311403019909 OpgC protein; Region: OpgC_C; cl17858 311403019910 Acyltransferase family; Region: Acyl_transf_3; pfam01757 311403019911 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 311403019912 Putative glucoamylase; Region: Glycoamylase; pfam10091 311403019913 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 311403019914 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 311403019915 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 311403019916 Protein of unknown function, DUF608; Region: DUF608; pfam04685 311403019917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403019918 non-specific DNA binding site [nucleotide binding]; other site 311403019919 salt bridge; other site 311403019920 sequence-specific DNA binding site [nucleotide binding]; other site 311403019921 Cupin domain; Region: Cupin_2; pfam07883 311403019922 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403019923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019924 dimer interface [polypeptide binding]; other site 311403019925 ABC-ATPase subunit interface; other site 311403019926 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403019927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403019928 dimer interface [polypeptide binding]; other site 311403019929 conserved gate region; other site 311403019930 putative PBP binding loops; other site 311403019931 ABC-ATPase subunit interface; other site 311403019932 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403019933 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 311403019934 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 311403019935 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 311403019936 active site 311403019937 dimer interface [polypeptide binding]; other site 311403019938 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 311403019939 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 311403019940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 311403019941 Integrase core domain; Region: rve; pfam00665 311403019942 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 311403019943 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 311403019944 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 311403019945 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 311403019946 prevent-host-death family protein; Region: phd_fam; TIGR01552 311403019947 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403019948 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403019949 TM-ABC transporter signature motif; other site 311403019950 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403019951 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403019952 Walker A/P-loop; other site 311403019953 ATP binding site [chemical binding]; other site 311403019954 Q-loop/lid; other site 311403019955 ABC transporter signature motif; other site 311403019956 Walker B; other site 311403019957 D-loop; other site 311403019958 H-loop/switch region; other site 311403019959 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403019960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403019961 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 311403019962 putative ligand binding site [chemical binding]; other site 311403019963 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 311403019964 Sulfatase; Region: Sulfatase; cl17466 311403019965 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 311403019966 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 311403019967 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 311403019968 NAD binding site [chemical binding]; other site 311403019969 homodimer interface [polypeptide binding]; other site 311403019970 active site 311403019971 substrate binding site [chemical binding]; other site 311403019972 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 311403019973 MobA/MobL family; Region: MobA_MobL; pfam03389 311403019974 AAA domain; Region: AAA_30; pfam13604 311403019975 Family description; Region: UvrD_C_2; pfam13538 311403019976 TraC-like protein; Region: TraC; pfam07820 311403019977 Conjugal transfer protein TraD; Region: TraD; pfam06412 311403019978 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 311403019979 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 311403019980 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 311403019981 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 311403019982 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 311403019983 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 311403019984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403019985 NAD(P) binding site [chemical binding]; other site 311403019986 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403019987 active site 311403019988 Bacterial sugar transferase; Region: Bac_transf; pfam02397 311403019989 O-Antigen ligase; Region: Wzy_C; pfam04932 311403019990 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 311403019991 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 311403019992 Walker A motif; other site 311403019993 hexamer interface [polypeptide binding]; other site 311403019994 ATP binding site [chemical binding]; other site 311403019995 Walker B motif; other site 311403019996 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 311403019997 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 311403019998 VirB7 interaction site; other site 311403019999 Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736 311403020000 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 311403020001 Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704 311403020002 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 311403020003 Type IV secretion system proteins; Region: T4SS; pfam07996 311403020004 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 311403020005 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 311403020006 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 311403020007 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 311403020008 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 311403020009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403020010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403020011 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403020012 dimerization interface [polypeptide binding]; other site 311403020013 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403020014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020015 dimer interface [polypeptide binding]; other site 311403020016 conserved gate region; other site 311403020017 putative PBP binding loops; other site 311403020018 ABC-ATPase subunit interface; other site 311403020019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020020 dimer interface [polypeptide binding]; other site 311403020021 conserved gate region; other site 311403020022 putative PBP binding loops; other site 311403020023 ABC-ATPase subunit interface; other site 311403020024 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 311403020025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403020026 substrate binding pocket [chemical binding]; other site 311403020027 membrane-bound complex binding site; other site 311403020028 hinge residues; other site 311403020029 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 311403020030 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 311403020031 putative active site [active] 311403020032 putative metal binding site [ion binding]; other site 311403020033 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 311403020034 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403020035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403020036 non-specific DNA binding site [nucleotide binding]; other site 311403020037 salt bridge; other site 311403020038 sequence-specific DNA binding site [nucleotide binding]; other site 311403020039 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403020040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403020041 non-specific DNA binding site [nucleotide binding]; other site 311403020042 salt bridge; other site 311403020043 sequence-specific DNA binding site [nucleotide binding]; other site 311403020044 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 311403020045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403020046 putative substrate translocation pore; other site 311403020047 H+ Antiporter protein; Region: 2A0121; TIGR00900 311403020048 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403020049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403020050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403020051 S-adenosylmethionine binding site [chemical binding]; other site 311403020052 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 311403020053 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 311403020054 Walker A motif; other site 311403020055 ATP binding site [chemical binding]; other site 311403020056 Walker B motif; other site 311403020057 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403020058 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 311403020059 putative ADP-binding pocket [chemical binding]; other site 311403020060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 311403020061 Transposase; Region: HTH_Tnp_1; pfam01527 311403020062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403020063 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 311403020064 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 311403020065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403020066 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 311403020067 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403020068 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 311403020069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403020070 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 311403020071 Transposase; Region: HTH_Tnp_1; pfam01527 311403020072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 311403020073 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403020074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403020075 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 311403020076 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 311403020077 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403020078 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 311403020079 Probable Catalytic site; other site 311403020080 metal-binding site 311403020081 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 311403020082 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 311403020083 Probable Catalytic site; other site 311403020084 metal-binding site 311403020085 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403020086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403020087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403020088 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403020089 catalytic core [active] 311403020090 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 311403020091 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 311403020092 substrate binding site; other site 311403020093 tetramer interface; other site 311403020094 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 311403020095 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 311403020096 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 311403020097 NAD binding site [chemical binding]; other site 311403020098 substrate binding site [chemical binding]; other site 311403020099 homodimer interface [polypeptide binding]; other site 311403020100 active site 311403020101 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 311403020102 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 311403020103 NADP binding site [chemical binding]; other site 311403020104 active site 311403020105 putative substrate binding site [chemical binding]; other site 311403020106 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 311403020107 ABC-2 type transporter; Region: ABC2_membrane; cl17235 311403020108 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 311403020109 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 311403020110 Walker A/P-loop; other site 311403020111 ATP binding site [chemical binding]; other site 311403020112 Q-loop/lid; other site 311403020113 ABC transporter signature motif; other site 311403020114 Walker B; other site 311403020115 D-loop; other site 311403020116 H-loop/switch region; other site 311403020117 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403020118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403020119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403020120 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403020121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 311403020122 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 311403020123 acyl-activating enzyme (AAE) consensus motif; other site 311403020124 active site 311403020125 AMP binding site [chemical binding]; other site 311403020126 CoA binding site [chemical binding]; other site 311403020127 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u6; cd10930 311403020128 NodB motif; other site 311403020129 putative active site [active] 311403020130 putative catalytic site [active] 311403020131 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 311403020132 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 311403020133 active site 311403020134 homodimer interface [polypeptide binding]; other site 311403020135 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 311403020136 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403020137 putative homodimer interface [polypeptide binding]; other site 311403020138 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 311403020139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944 311403020140 RNA polymerase sigma factor; Provisional; Region: PRK12512 311403020141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 311403020142 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 311403020143 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 311403020144 hypothetical protein; Provisional; Region: PRK05409 311403020145 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 311403020146 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 311403020147 Cupin domain; Region: Cupin_2; pfam07883 311403020148 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 311403020149 TROVE domain; Region: TROVE; pfam05731 311403020150 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 311403020151 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 311403020152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403020153 Walker A motif; other site 311403020154 ATP binding site [chemical binding]; other site 311403020155 Walker B motif; other site 311403020156 arginine finger; other site 311403020157 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 311403020158 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 311403020159 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 311403020160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403020161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403020162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403020163 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403020164 GTPase CgtA; Reviewed; Region: obgE; PRK12299 311403020165 GTP1/OBG; Region: GTP1_OBG; pfam01018 311403020166 Obg GTPase; Region: Obg; cd01898 311403020167 G1 box; other site 311403020168 GTP/Mg2+ binding site [chemical binding]; other site 311403020169 Switch I region; other site 311403020170 G2 box; other site 311403020171 G3 box; other site 311403020172 Switch II region; other site 311403020173 G4 box; other site 311403020174 G5 box; other site 311403020175 gamma-glutamyl kinase; Provisional; Region: PRK05429 311403020176 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 311403020177 nucleotide binding site [chemical binding]; other site 311403020178 homotetrameric interface [polypeptide binding]; other site 311403020179 putative phosphate binding site [ion binding]; other site 311403020180 putative allosteric binding site; other site 311403020181 PUA domain; Region: PUA; pfam01472 311403020182 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 311403020183 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 311403020184 putative catalytic cysteine [active] 311403020185 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 311403020186 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 311403020187 active site 311403020188 (T/H)XGH motif; other site 311403020189 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 311403020190 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 311403020191 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 311403020192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020193 dimer interface [polypeptide binding]; other site 311403020194 conserved gate region; other site 311403020195 putative PBP binding loops; other site 311403020196 ABC-ATPase subunit interface; other site 311403020197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403020198 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 311403020199 Walker A/P-loop; other site 311403020200 ATP binding site [chemical binding]; other site 311403020201 Q-loop/lid; other site 311403020202 ABC transporter signature motif; other site 311403020203 Walker B; other site 311403020204 D-loop; other site 311403020205 H-loop/switch region; other site 311403020206 TOBE domain; Region: TOBE; cl01440 311403020207 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 311403020208 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 311403020209 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 311403020210 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 311403020211 Peptidase family M23; Region: Peptidase_M23; pfam01551 311403020212 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 311403020213 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 311403020214 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 311403020215 protein binding site [polypeptide binding]; other site 311403020216 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 311403020217 Catalytic dyad [active] 311403020218 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 311403020219 NodB motif; other site 311403020220 putative active site [active] 311403020221 putative catalytic site [active] 311403020222 Zn binding site [ion binding]; other site 311403020223 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 311403020224 putative active site [active] 311403020225 Ap4A binding site [chemical binding]; other site 311403020226 nudix motif; other site 311403020227 putative metal binding site [ion binding]; other site 311403020228 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 311403020229 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 311403020230 ferroxidase pore; other site 311403020231 ferroxidase diiron center [ion binding]; other site 311403020232 heme binding site [chemical binding]; other site 311403020233 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 311403020234 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 311403020235 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 311403020236 putative active site [active] 311403020237 putative PHP Thumb interface [polypeptide binding]; other site 311403020238 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 311403020239 generic binding surface II; other site 311403020240 generic binding surface I; other site 311403020241 DNA Polymerase Y-family; Region: PolY_like; cd03468 311403020242 active site 311403020243 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 311403020244 DNA binding site [nucleotide binding] 311403020245 Uncharacterized conserved protein [Function unknown]; Region: COG4544 311403020246 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 311403020247 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 311403020248 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 311403020249 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 311403020250 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 311403020251 substrate binding site [chemical binding]; other site 311403020252 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403020253 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403020254 Metal-binding active site; metal-binding site 311403020255 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 311403020256 tartrate dehydrogenase; Region: TTC; TIGR02089 311403020257 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 311403020258 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 311403020259 active site 311403020260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403020261 dimerization interface [polypeptide binding]; other site 311403020262 putative DNA binding site [nucleotide binding]; other site 311403020263 putative Zn2+ binding site [ion binding]; other site 311403020264 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403020265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403020266 NAD(P) binding site [chemical binding]; other site 311403020267 active site 311403020268 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 311403020269 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 311403020270 dimerization interface [polypeptide binding]; other site 311403020271 DPS ferroxidase diiron center [ion binding]; other site 311403020272 ion pore; other site 311403020273 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 311403020274 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 311403020275 Transglycosylase SLT domain; Region: SLT_2; pfam13406 311403020276 murein hydrolase B; Provisional; Region: PRK10760; cl17906 311403020277 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 311403020278 active site clefts [active] 311403020279 zinc binding site [ion binding]; other site 311403020280 dimer interface [polypeptide binding]; other site 311403020281 pyridoxamine kinase; Validated; Region: PRK05756 311403020282 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 311403020283 pyridoxal binding site [chemical binding]; other site 311403020284 dimer interface [polypeptide binding]; other site 311403020285 ATP binding site [chemical binding]; other site 311403020286 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 311403020287 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 311403020288 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 311403020289 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 311403020290 purine monophosphate binding site [chemical binding]; other site 311403020291 dimer interface [polypeptide binding]; other site 311403020292 putative catalytic residues [active] 311403020293 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 311403020294 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 311403020295 NusB family; Region: NusB; pfam01029 311403020296 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 311403020297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403020298 S-adenosylmethionine binding site [chemical binding]; other site 311403020299 heat shock protein HtpX; Provisional; Region: PRK01345 311403020300 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 311403020301 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 311403020302 acetyl-CoA synthetase; Provisional; Region: PRK00174 311403020303 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 311403020304 active site 311403020305 CoA binding site [chemical binding]; other site 311403020306 acyl-activating enzyme (AAE) consensus motif; other site 311403020307 AMP binding site [chemical binding]; other site 311403020308 acetate binding site [chemical binding]; other site 311403020309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 311403020310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 311403020311 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 311403020312 catalytic residue [active] 311403020313 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 311403020314 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 311403020315 HIGH motif; other site 311403020316 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 311403020317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 311403020318 active site 311403020319 KMSKS motif; other site 311403020320 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 311403020321 tRNA binding surface [nucleotide binding]; other site 311403020322 Lipopolysaccharide-assembly; Region: LptE; cl01125 311403020323 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 311403020324 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 311403020325 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 311403020326 ParB-like nuclease domain; Region: ParBc; pfam02195 311403020327 KorB domain; Region: KorB; pfam08535 311403020328 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 311403020329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403020330 P-loop; other site 311403020331 Magnesium ion binding site [ion binding]; other site 311403020332 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403020333 Magnesium ion binding site [ion binding]; other site 311403020334 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 311403020335 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 311403020336 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 311403020337 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 311403020338 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 311403020339 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 311403020340 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 311403020341 trmE is a tRNA modification GTPase; Region: trmE; cd04164 311403020342 G1 box; other site 311403020343 GTP/Mg2+ binding site [chemical binding]; other site 311403020344 Switch I region; other site 311403020345 G2 box; other site 311403020346 Switch II region; other site 311403020347 G3 box; other site 311403020348 G4 box; other site 311403020349 G5 box; other site 311403020350 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 311403020351 transcription termination factor Rho; Provisional; Region: rho; PRK09376 311403020352 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 311403020353 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 311403020354 RNA binding site [nucleotide binding]; other site 311403020355 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 311403020356 multimer interface [polypeptide binding]; other site 311403020357 Walker A motif; other site 311403020358 ATP binding site [chemical binding]; other site 311403020359 Walker B motif; other site 311403020360 Predicted membrane protein [Function unknown]; Region: COG1981 311403020361 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 311403020362 substrate binding site [chemical binding]; other site 311403020363 active site 311403020364 Abi-like protein; Region: Abi_2; pfam07751 311403020365 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 311403020366 PLD-like domain; Region: PLDc_2; pfam13091 311403020367 putative homodimer interface [polypeptide binding]; other site 311403020368 putative active site [active] 311403020369 catalytic site [active] 311403020370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403020371 non-specific DNA binding site [nucleotide binding]; other site 311403020372 salt bridge; other site 311403020373 sequence-specific DNA binding site [nucleotide binding]; other site 311403020374 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 311403020375 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 311403020376 HTH DNA binding domain; Region: HTH_13; pfam11972 311403020377 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 311403020378 DNA binding site [nucleotide binding] 311403020379 dimer interface [polypeptide binding]; other site 311403020380 active site 311403020381 Int/Topo IB signature motif; other site 311403020382 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 311403020383 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 311403020384 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 311403020385 N-terminal domain interface [polypeptide binding]; other site 311403020386 dimer interface [polypeptide binding]; other site 311403020387 substrate binding pocket (H-site) [chemical binding]; other site 311403020388 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 311403020389 IHF - DNA interface [nucleotide binding]; other site 311403020390 IHF dimer interface [polypeptide binding]; other site 311403020391 hypothetical protein; Provisional; Region: 57B; PHA02574 311403020392 Domain of unknown function (DUF932); Region: DUF932; cl12129 311403020393 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 311403020394 Protein of unknown function (DUF736); Region: DUF736; pfam05284 311403020395 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 311403020396 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403020397 P-loop; other site 311403020398 Magnesium ion binding site [ion binding]; other site 311403020399 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 311403020400 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403020401 Magnesium ion binding site [ion binding]; other site 311403020402 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 311403020403 ParB-like nuclease domain; Region: ParBc; pfam02195 311403020404 replication initiation protein RepC; Provisional; Region: PRK13824 311403020405 Replication protein C N-terminal domain; Region: RP-C; pfam03428 311403020406 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 311403020407 ProQ/FINO family; Region: ProQ; pfam04352 311403020408 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 311403020409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403020410 non-specific DNA binding site [nucleotide binding]; other site 311403020411 salt bridge; other site 311403020412 sequence-specific DNA binding site [nucleotide binding]; other site 311403020413 HipA N-terminal domain; Region: Couple_hipA; cl11853 311403020414 HipA-like N-terminal domain; Region: HipA_N; pfam07805 311403020415 HipA-like C-terminal domain; Region: HipA_C; pfam07804 311403020416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403020417 non-specific DNA binding site [nucleotide binding]; other site 311403020418 salt bridge; other site 311403020419 sequence-specific DNA binding site [nucleotide binding]; other site 311403020420 ParA-like protein; Provisional; Region: PHA02518 311403020421 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403020422 P-loop; other site 311403020423 Magnesium ion binding site [ion binding]; other site 311403020424 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 311403020425 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 311403020426 Alphaherpesvirus glycoprotein I; Region: Herpes_gI; cl17328 311403020427 Abi-like protein; Region: Abi_2; pfam07751 311403020428 glucose-inhibited division protein A; Region: gidA; TIGR00136 311403020429 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 311403020430 Methyltransferase domain; Region: Methyltransf_26; pfam13659 311403020431 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 311403020432 Protein of unknown function (DUF736); Region: DUF736; cl02303 311403020433 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 311403020434 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 311403020435 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 311403020436 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 311403020437 N-acetyl-D-glucosamine binding site [chemical binding]; other site 311403020438 catalytic residue [active] 311403020439 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 311403020440 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 311403020441 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 311403020442 Type IV secretion system proteins; Region: T4SS; pfam07996 311403020443 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 311403020444 VirB8 protein; Region: VirB8; pfam04335 311403020445 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 311403020446 VirB7 interaction site; other site 311403020447 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 311403020448 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 311403020449 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 311403020450 Walker A motif; other site 311403020451 hexamer interface [polypeptide binding]; other site 311403020452 ATP binding site [chemical binding]; other site 311403020453 Walker B motif; other site 311403020454 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 311403020455 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 311403020456 Walker A motif; other site 311403020457 ATP binding site [chemical binding]; other site 311403020458 Walker B motif; other site 311403020459 Replication protein C N-terminal domain; Region: RP-C; pfam03428 311403020460 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 311403020461 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403020462 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 311403020463 Transposase; Region: HTH_Tnp_1; cl17663 311403020464 Phosphotransferase enzyme family; Region: APH; pfam01636 311403020465 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 311403020466 active site 311403020467 substrate binding site [chemical binding]; other site 311403020468 ATP binding site [chemical binding]; other site 311403020469 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 311403020470 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 311403020471 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 311403020472 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 311403020473 putative active site [active] 311403020474 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 311403020475 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 311403020476 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 311403020477 active site 311403020478 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 311403020479 dimer interface [polypeptide binding]; other site 311403020480 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 311403020481 Ligand Binding Site [chemical binding]; other site 311403020482 Molecular Tunnel; other site 311403020483 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 311403020484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403020485 active site 311403020486 motif I; other site 311403020487 motif II; other site 311403020488 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 311403020489 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 311403020490 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 311403020491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403020492 Walker A/P-loop; other site 311403020493 ATP binding site [chemical binding]; other site 311403020494 ABC transporter signature motif; other site 311403020495 Walker B; other site 311403020496 D-loop; other site 311403020497 H-loop/switch region; other site 311403020498 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 311403020499 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 311403020500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403020501 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 311403020502 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403020503 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 311403020504 Helix-turn-helix domain; Region: HTH_28; pfam13518 311403020505 Winged helix-turn helix; Region: HTH_29; pfam13551 311403020506 Homeodomain-like domain; Region: HTH_32; pfam13565 311403020507 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 311403020508 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 311403020509 catalytic residues [active] 311403020510 catalytic nucleophile [active] 311403020511 Recombinase; Region: Recombinase; pfam07508 311403020512 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 311403020513 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 311403020514 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 311403020515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403020516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 311403020517 Transposase; Region: HTH_Tnp_1; pfam01527 311403020518 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 311403020519 active site 311403020520 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 311403020521 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403020522 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403020523 active site 311403020524 non-prolyl cis peptide bond; other site 311403020525 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403020526 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 311403020527 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 311403020528 NMT1/THI5 like; Region: NMT1; pfam09084 311403020529 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 311403020530 intersubunit interface [polypeptide binding]; other site 311403020531 active site 311403020532 Zn2+ binding site [ion binding]; other site 311403020533 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 311403020534 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 311403020535 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 311403020536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403020537 Walker A/P-loop; other site 311403020538 ATP binding site [chemical binding]; other site 311403020539 Q-loop/lid; other site 311403020540 ABC transporter signature motif; other site 311403020541 Walker B; other site 311403020542 D-loop; other site 311403020543 H-loop/switch region; other site 311403020544 TOBE domain; Region: TOBE_2; pfam08402 311403020545 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 311403020546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020547 dimer interface [polypeptide binding]; other site 311403020548 conserved gate region; other site 311403020549 putative PBP binding loops; other site 311403020550 ABC-ATPase subunit interface; other site 311403020551 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 311403020552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020553 dimer interface [polypeptide binding]; other site 311403020554 conserved gate region; other site 311403020555 putative PBP binding loops; other site 311403020556 ABC-ATPase subunit interface; other site 311403020557 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 311403020558 Transcriptional regulator [Transcription]; Region: IclR; COG1414 311403020559 Bacterial transcriptional regulator; Region: IclR; pfam01614 311403020560 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 311403020561 classical (c) SDRs; Region: SDR_c; cd05233 311403020562 NAD(P) binding site [chemical binding]; other site 311403020563 active site 311403020564 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 311403020565 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403020566 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 311403020567 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 311403020568 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 311403020569 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 311403020570 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 311403020571 inhibitor binding site; inhibition site 311403020572 catalytic Zn binding site [ion binding]; other site 311403020573 structural Zn binding site [ion binding]; other site 311403020574 NADP binding site [chemical binding]; other site 311403020575 tetramer interface [polypeptide binding]; other site 311403020576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403020577 short chain dehydrogenase; Provisional; Region: PRK07060 311403020578 NAD(P) binding site [chemical binding]; other site 311403020579 active site 311403020580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403020581 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403020582 TM-ABC transporter signature motif; other site 311403020583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403020584 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403020585 TM-ABC transporter signature motif; other site 311403020586 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403020587 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403020588 Walker A/P-loop; other site 311403020589 ATP binding site [chemical binding]; other site 311403020590 Q-loop/lid; other site 311403020591 ABC transporter signature motif; other site 311403020592 Walker B; other site 311403020593 D-loop; other site 311403020594 H-loop/switch region; other site 311403020595 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403020596 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403020597 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 311403020598 putative ligand binding site [chemical binding]; other site 311403020599 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403020600 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403020601 DNA binding site [nucleotide binding] 311403020602 domain linker motif; other site 311403020603 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 311403020604 putative dimerization interface [polypeptide binding]; other site 311403020605 putative ligand binding site [chemical binding]; other site 311403020606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 311403020607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403020608 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 311403020609 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 311403020610 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 311403020611 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 311403020612 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 311403020613 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 311403020614 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 311403020615 Ligand binding site [chemical binding]; other site 311403020616 Electron transfer flavoprotein domain; Region: ETF; pfam01012 311403020617 choline dehydrogenase; Validated; Region: PRK02106 311403020618 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403020619 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403020620 FCD domain; Region: FCD; pfam07729 311403020621 EamA-like transporter family; Region: EamA; pfam00892 311403020622 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 311403020623 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403020624 Walker A/P-loop; other site 311403020625 ATP binding site [chemical binding]; other site 311403020626 Q-loop/lid; other site 311403020627 ABC transporter signature motif; other site 311403020628 Walker B; other site 311403020629 D-loop; other site 311403020630 H-loop/switch region; other site 311403020631 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403020632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020633 dimer interface [polypeptide binding]; other site 311403020634 conserved gate region; other site 311403020635 putative PBP binding loops; other site 311403020636 ABC-ATPase subunit interface; other site 311403020637 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403020638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403020639 substrate binding pocket [chemical binding]; other site 311403020640 membrane-bound complex binding site; other site 311403020641 hinge residues; other site 311403020642 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403020643 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 311403020644 tetramerization interface [polypeptide binding]; other site 311403020645 NAD(P) binding site [chemical binding]; other site 311403020646 catalytic residues [active] 311403020647 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403020648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 311403020649 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403020650 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403020651 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403020652 Transcriptional regulators [Transcription]; Region: GntR; COG1802 311403020653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403020654 DNA-binding site [nucleotide binding]; DNA binding site 311403020655 FCD domain; Region: FCD; pfam07729 311403020656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403020657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403020658 dimerization interface [polypeptide binding]; other site 311403020659 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 311403020660 active site 1 [active] 311403020661 dimer interface [polypeptide binding]; other site 311403020662 hexamer interface [polypeptide binding]; other site 311403020663 active site 2 [active] 311403020664 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403020665 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 311403020666 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403020667 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403020668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020669 dimer interface [polypeptide binding]; other site 311403020670 conserved gate region; other site 311403020671 putative PBP binding loops; other site 311403020672 ABC-ATPase subunit interface; other site 311403020673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403020674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020675 dimer interface [polypeptide binding]; other site 311403020676 conserved gate region; other site 311403020677 putative PBP binding loops; other site 311403020678 ABC-ATPase subunit interface; other site 311403020679 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 311403020680 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403020681 Walker A/P-loop; other site 311403020682 ATP binding site [chemical binding]; other site 311403020683 Q-loop/lid; other site 311403020684 ABC transporter signature motif; other site 311403020685 Walker B; other site 311403020686 D-loop; other site 311403020687 H-loop/switch region; other site 311403020688 TOBE domain; Region: TOBE_2; pfam08402 311403020689 sorbitol dehydrogenase; Provisional; Region: PRK07067 311403020690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403020691 NAD(P) binding site [chemical binding]; other site 311403020692 active site 311403020693 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 311403020694 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 311403020695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403020696 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 311403020697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 311403020698 dimerization interface [polypeptide binding]; other site 311403020699 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 311403020700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 311403020701 dimer interface [polypeptide binding]; other site 311403020702 putative CheW interface [polypeptide binding]; other site 311403020703 Serine hydrolase; Region: Ser_hydrolase; cl17834 311403020704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403020705 Predicted amidohydrolase [General function prediction only]; Region: COG0388 311403020706 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 311403020707 putative active site [active] 311403020708 catalytic triad [active] 311403020709 putative dimer interface [polypeptide binding]; other site 311403020710 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 311403020711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403020712 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 311403020713 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 311403020714 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 311403020715 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 311403020716 Cytochrome c; Region: Cytochrom_C; pfam00034 311403020717 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 311403020718 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 311403020719 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403020720 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 311403020721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 311403020722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 311403020723 DNA binding site [nucleotide binding] 311403020724 domain linker motif; other site 311403020725 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 311403020726 Tannase and feruloyl esterase; Region: Tannase; pfam07519 311403020727 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 311403020728 TAP-like protein; Region: Abhydrolase_4; pfam08386 311403020729 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403020730 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 311403020731 Walker A/P-loop; other site 311403020732 ATP binding site [chemical binding]; other site 311403020733 Q-loop/lid; other site 311403020734 ABC transporter signature motif; other site 311403020735 Walker B; other site 311403020736 D-loop; other site 311403020737 H-loop/switch region; other site 311403020738 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 311403020739 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 311403020740 Walker A/P-loop; other site 311403020741 ATP binding site [chemical binding]; other site 311403020742 Q-loop/lid; other site 311403020743 ABC transporter signature motif; other site 311403020744 Walker B; other site 311403020745 D-loop; other site 311403020746 H-loop/switch region; other site 311403020747 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403020748 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403020749 TM-ABC transporter signature motif; other site 311403020750 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403020751 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403020752 TM-ABC transporter signature motif; other site 311403020753 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403020754 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 311403020755 putative ligand binding site [chemical binding]; other site 311403020756 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 311403020757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403020758 NAD(P) binding site [chemical binding]; other site 311403020759 active site 311403020760 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 311403020761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 311403020762 catalytic loop [active] 311403020763 iron binding site [ion binding]; other site 311403020764 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 311403020765 FAD binding pocket [chemical binding]; other site 311403020766 FAD binding motif [chemical binding]; other site 311403020767 phosphate binding motif [ion binding]; other site 311403020768 beta-alpha-beta structure motif; other site 311403020769 NAD binding pocket [chemical binding]; other site 311403020770 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 311403020771 inter-subunit interface; other site 311403020772 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 311403020773 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 311403020774 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 311403020775 putative alpha subunit interface [polypeptide binding]; other site 311403020776 putative active site [active] 311403020777 putative substrate binding site [chemical binding]; other site 311403020778 Fe binding site [ion binding]; other site 311403020779 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 311403020780 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 311403020781 dimer interface [polypeptide binding]; other site 311403020782 active site 311403020783 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 311403020784 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 311403020785 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 311403020786 metal binding site [ion binding]; metal-binding site 311403020787 substrate binding pocket [chemical binding]; other site 311403020788 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 311403020789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403020790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403020791 dimerization interface [polypeptide binding]; other site 311403020792 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 311403020793 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 311403020794 NAD(P) binding site [chemical binding]; other site 311403020795 catalytic residues [active] 311403020796 choline dehydrogenase; Validated; Region: PRK02106 311403020797 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403020798 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 311403020799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403020800 Helix-turn-helix domain; Region: HTH_18; pfam12833 311403020801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403020802 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 311403020803 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 311403020804 metal binding site [ion binding]; metal-binding site 311403020805 substrate binding pocket [chemical binding]; other site 311403020806 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 311403020807 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 311403020808 phosphate binding site [ion binding]; other site 311403020809 benzoylformate decarboxylase; Reviewed; Region: PRK07092 311403020810 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 311403020811 PYR/PP interface [polypeptide binding]; other site 311403020812 dimer interface [polypeptide binding]; other site 311403020813 TPP binding site [chemical binding]; other site 311403020814 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 311403020815 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 311403020816 TPP-binding site [chemical binding]; other site 311403020817 dimer interface [polypeptide binding]; other site 311403020818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403020819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403020820 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 311403020821 substrate binding pocket [chemical binding]; other site 311403020822 dimerization interface [polypeptide binding]; other site 311403020823 Predicted amidohydrolase [General function prediction only]; Region: COG0388 311403020824 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 311403020825 putative active site [active] 311403020826 catalytic triad [active] 311403020827 putative dimer interface [polypeptide binding]; other site 311403020828 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 311403020829 Predicted amidohydrolase [General function prediction only]; Region: COG0388 311403020830 putative active site [active] 311403020831 catalytic triad [active] 311403020832 putative dimer interface [polypeptide binding]; other site 311403020833 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 311403020834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 311403020835 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 311403020836 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 311403020837 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 311403020838 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 311403020839 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 311403020840 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 311403020841 pyruvate dehydrogenase; Provisional; Region: PRK09124 311403020842 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 311403020843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403020844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403020845 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 311403020846 putative effector binding pocket; other site 311403020847 dimerization interface [polypeptide binding]; other site 311403020848 Predicted membrane protein [Function unknown]; Region: COG2259 311403020849 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 311403020850 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 311403020851 putative metal binding site [ion binding]; other site 311403020852 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 311403020853 active site 311403020854 metal binding site [ion binding]; metal-binding site 311403020855 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 311403020856 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 311403020857 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 311403020858 putative dimer interface [polypeptide binding]; other site 311403020859 N-terminal domain interface [polypeptide binding]; other site 311403020860 putative substrate binding pocket (H-site) [chemical binding]; other site 311403020861 putative hydrolase; Provisional; Region: PRK11460 311403020862 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 311403020863 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 311403020864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403020865 putative substrate translocation pore; other site 311403020866 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 311403020867 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 311403020868 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 311403020869 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 311403020870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403020871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403020872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 311403020873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403020874 DNA binding residues [nucleotide binding] 311403020875 dimerization interface [polypeptide binding]; other site 311403020876 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 311403020877 active site 311403020878 Mn binding site [ion binding]; other site 311403020879 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 311403020880 active site 311403020881 Mn binding site [ion binding]; other site 311403020882 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403020883 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 311403020884 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403020885 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403020886 Walker A/P-loop; other site 311403020887 ATP binding site [chemical binding]; other site 311403020888 Q-loop/lid; other site 311403020889 ABC transporter signature motif; other site 311403020890 Walker B; other site 311403020891 D-loop; other site 311403020892 H-loop/switch region; other site 311403020893 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403020894 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403020895 Walker A/P-loop; other site 311403020896 ATP binding site [chemical binding]; other site 311403020897 Q-loop/lid; other site 311403020898 ABC transporter signature motif; other site 311403020899 Walker B; other site 311403020900 D-loop; other site 311403020901 H-loop/switch region; other site 311403020902 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 311403020903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020904 dimer interface [polypeptide binding]; other site 311403020905 conserved gate region; other site 311403020906 putative PBP binding loops; other site 311403020907 ABC-ATPase subunit interface; other site 311403020908 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403020909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403020910 dimer interface [polypeptide binding]; other site 311403020911 conserved gate region; other site 311403020912 putative PBP binding loops; other site 311403020913 ABC-ATPase subunit interface; other site 311403020914 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 311403020915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403020916 Walker A/P-loop; other site 311403020917 ATP binding site [chemical binding]; other site 311403020918 Q-loop/lid; other site 311403020919 ABC transporter signature motif; other site 311403020920 Walker B; other site 311403020921 D-loop; other site 311403020922 H-loop/switch region; other site 311403020923 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 311403020924 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 311403020925 TM-ABC transporter signature motif; other site 311403020926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403020927 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 311403020928 Walker A/P-loop; other site 311403020929 ATP binding site [chemical binding]; other site 311403020930 Q-loop/lid; other site 311403020931 ABC transporter signature motif; other site 311403020932 Walker B; other site 311403020933 D-loop; other site 311403020934 H-loop/switch region; other site 311403020935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403020936 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 311403020937 TM-ABC transporter signature motif; other site 311403020938 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 311403020939 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 311403020940 putative ligand binding site [chemical binding]; other site 311403020941 indole acetimide hydrolase; Validated; Region: PRK07488 311403020942 Amidase; Region: Amidase; cl11426 311403020943 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 311403020944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403020945 active site 311403020946 motif I; other site 311403020947 motif II; other site 311403020948 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 311403020949 oligomerisation interface [polypeptide binding]; other site 311403020950 mobile loop; other site 311403020951 roof hairpin; other site 311403020952 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 311403020953 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 311403020954 ring oligomerisation interface [polypeptide binding]; other site 311403020955 ATP/Mg binding site [chemical binding]; other site 311403020956 stacking interactions; other site 311403020957 hinge regions; other site 311403020958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403020959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403020960 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 311403020961 active site 311403020962 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 311403020963 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 311403020964 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 311403020965 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 311403020966 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 311403020967 Ligand binding site [chemical binding]; other site 311403020968 Electron transfer flavoprotein domain; Region: ETF; pfam01012 311403020969 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 311403020970 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 311403020971 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 311403020972 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 311403020973 ligand binding site [chemical binding]; other site 311403020974 homodimer interface [polypeptide binding]; other site 311403020975 NAD(P) binding site [chemical binding]; other site 311403020976 trimer interface B [polypeptide binding]; other site 311403020977 trimer interface A [polypeptide binding]; other site 311403020978 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 311403020979 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 311403020980 Predicted flavoprotein [General function prediction only]; Region: COG0431 311403020981 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 311403020982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403020983 ABC transporter signature motif; other site 311403020984 Walker B; other site 311403020985 D-loop; other site 311403020986 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 311403020987 active site 311403020988 Fe(II) binding site [ion binding]; other site 311403020989 dimer interface [polypeptide binding]; other site 311403020990 tetramer interface [polypeptide binding]; other site 311403020991 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cd07321 311403020992 dimer interface [polypeptide binding]; other site 311403020993 tetramer interface [polypeptide binding]; other site 311403020994 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 311403020995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 311403020996 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 311403020997 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 311403020998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403020999 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 311403021000 NAD(P) binding site [chemical binding]; other site 311403021001 active site 311403021002 Cupin domain; Region: Cupin_2; pfam07883 311403021003 classical (c) SDRs; Region: SDR_c; cd05233 311403021004 NAD(P) binding site [chemical binding]; other site 311403021005 active site 311403021006 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 311403021007 histidinol dehydrogenase; Region: hisD; TIGR00069 311403021008 NAD binding site [chemical binding]; other site 311403021009 dimerization interface [polypeptide binding]; other site 311403021010 product binding site; other site 311403021011 substrate binding site [chemical binding]; other site 311403021012 zinc binding site [ion binding]; other site 311403021013 catalytic residues [active] 311403021014 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 311403021015 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 311403021016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 311403021017 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 311403021018 active site 311403021019 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403021020 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403021021 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 311403021022 tetramer interface [polypeptide binding]; other site 311403021023 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 311403021024 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 311403021025 active site 311403021026 metal binding site [ion binding]; metal-binding site 311403021027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403021028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403021029 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 311403021030 classical (c) SDRs; Region: SDR_c; cd05233 311403021031 NAD(P) binding site [chemical binding]; other site 311403021032 active site 311403021033 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403021034 classical (c) SDRs; Region: SDR_c; cd05233 311403021035 NAD(P) binding site [chemical binding]; other site 311403021036 active site 311403021037 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 311403021038 classical (c) SDRs; Region: SDR_c; cd05233 311403021039 NAD(P) binding site [chemical binding]; other site 311403021040 active site 311403021041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403021042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403021043 hypothetical protein; Provisional; Region: PRK06847 311403021044 hypothetical protein; Provisional; Region: PRK07236 311403021045 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 311403021046 NADH(P)-binding; Region: NAD_binding_10; pfam13460 311403021047 NAD binding site [chemical binding]; other site 311403021048 putative active site [active] 311403021049 substrate binding site [chemical binding]; other site 311403021050 Predicted transcriptional regulators [Transcription]; Region: COG1733 311403021051 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 311403021052 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 311403021053 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 311403021054 FAD binding pocket [chemical binding]; other site 311403021055 FAD binding motif [chemical binding]; other site 311403021056 phosphate binding motif [ion binding]; other site 311403021057 beta-alpha-beta structure motif; other site 311403021058 NAD binding pocket [chemical binding]; other site 311403021059 Ferredoxin [Energy production and conversion]; Region: COG1146 311403021060 4Fe-4S binding domain; Region: Fer4; cl02805 311403021061 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 311403021062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403021063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403021064 putative substrate translocation pore; other site 311403021065 Predicted oxidoreductase [General function prediction only]; Region: COG3573 311403021066 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 311403021067 SnoaL-like domain; Region: SnoaL_4; pfam13577 311403021068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403021069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403021070 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 311403021071 putative substrate binding pocket [chemical binding]; other site 311403021072 putative dimerization interface [polypeptide binding]; other site 311403021073 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 311403021074 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 311403021075 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403021076 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 311403021077 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 311403021078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403021079 substrate binding pocket [chemical binding]; other site 311403021080 membrane-bound complex binding site; other site 311403021081 hinge residues; other site 311403021082 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403021083 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403021084 Walker A/P-loop; other site 311403021085 ATP binding site [chemical binding]; other site 311403021086 Q-loop/lid; other site 311403021087 ABC transporter signature motif; other site 311403021088 Walker B; other site 311403021089 D-loop; other site 311403021090 H-loop/switch region; other site 311403021091 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403021092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403021093 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403021094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021095 dimer interface [polypeptide binding]; other site 311403021096 conserved gate region; other site 311403021097 putative PBP binding loops; other site 311403021098 ABC-ATPase subunit interface; other site 311403021099 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 311403021100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 311403021101 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 311403021102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403021103 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021104 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 311403021105 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021107 dimer interface [polypeptide binding]; other site 311403021108 conserved gate region; other site 311403021109 putative PBP binding loops; other site 311403021110 ABC-ATPase subunit interface; other site 311403021111 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403021112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021113 dimer interface [polypeptide binding]; other site 311403021114 conserved gate region; other site 311403021115 putative PBP binding loops; other site 311403021116 ABC-ATPase subunit interface; other site 311403021117 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403021118 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021119 Walker A/P-loop; other site 311403021120 ATP binding site [chemical binding]; other site 311403021121 Q-loop/lid; other site 311403021122 ABC transporter signature motif; other site 311403021123 Walker B; other site 311403021124 D-loop; other site 311403021125 H-loop/switch region; other site 311403021126 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021127 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021128 Walker A/P-loop; other site 311403021129 ATP binding site [chemical binding]; other site 311403021130 Q-loop/lid; other site 311403021131 ABC transporter signature motif; other site 311403021132 Walker B; other site 311403021133 D-loop; other site 311403021134 H-loop/switch region; other site 311403021135 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021136 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021137 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021138 active site 311403021139 non-prolyl cis peptide bond; other site 311403021140 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 311403021141 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 311403021142 dimer interface [polypeptide binding]; other site 311403021143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403021144 catalytic residue [active] 311403021145 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021146 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 311403021147 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 311403021149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021150 dimer interface [polypeptide binding]; other site 311403021151 conserved gate region; other site 311403021152 putative PBP binding loops; other site 311403021153 ABC-ATPase subunit interface; other site 311403021154 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403021155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021156 dimer interface [polypeptide binding]; other site 311403021157 conserved gate region; other site 311403021158 putative PBP binding loops; other site 311403021159 ABC-ATPase subunit interface; other site 311403021160 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403021161 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021162 Walker A/P-loop; other site 311403021163 ATP binding site [chemical binding]; other site 311403021164 Q-loop/lid; other site 311403021165 ABC transporter signature motif; other site 311403021166 Walker B; other site 311403021167 D-loop; other site 311403021168 H-loop/switch region; other site 311403021169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021170 Walker A/P-loop; other site 311403021171 ATP binding site [chemical binding]; other site 311403021172 Q-loop/lid; other site 311403021173 ABC transporter signature motif; other site 311403021174 Walker B; other site 311403021175 D-loop; other site 311403021176 H-loop/switch region; other site 311403021177 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021178 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021179 active site 311403021180 non-prolyl cis peptide bond; other site 311403021181 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 311403021182 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 311403021183 Walker A/P-loop; other site 311403021184 ATP binding site [chemical binding]; other site 311403021185 Q-loop/lid; other site 311403021186 ABC transporter signature motif; other site 311403021187 Walker B; other site 311403021188 D-loop; other site 311403021189 H-loop/switch region; other site 311403021190 TOBE domain; Region: TOBE_2; pfam08402 311403021191 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 311403021192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021193 dimer interface [polypeptide binding]; other site 311403021194 conserved gate region; other site 311403021195 putative PBP binding loops; other site 311403021196 ABC-ATPase subunit interface; other site 311403021197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021198 dimer interface [polypeptide binding]; other site 311403021199 conserved gate region; other site 311403021200 putative PBP binding loops; other site 311403021201 ABC-ATPase subunit interface; other site 311403021202 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 311403021203 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 311403021204 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 311403021205 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403021206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403021207 DNA-binding site [nucleotide binding]; DNA binding site 311403021208 FCD domain; Region: FCD; pfam07729 311403021209 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 311403021210 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 311403021211 inhibitor-cofactor binding pocket; inhibition site 311403021212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403021213 catalytic residue [active] 311403021214 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 311403021215 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 311403021216 MOFRL family; Region: MOFRL; pfam05161 311403021217 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403021218 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403021219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 311403021220 Transposase; Region: DEDD_Tnp_IS110; pfam01548 311403021221 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 311403021222 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403021223 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403021224 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403021225 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 311403021226 putative ligand binding site [chemical binding]; other site 311403021227 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403021228 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403021229 TM-ABC transporter signature motif; other site 311403021230 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403021231 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403021232 Walker A/P-loop; other site 311403021233 ATP binding site [chemical binding]; other site 311403021234 Q-loop/lid; other site 311403021235 ABC transporter signature motif; other site 311403021236 Walker B; other site 311403021237 D-loop; other site 311403021238 H-loop/switch region; other site 311403021239 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403021240 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 311403021241 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403021242 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 311403021243 nucleotide binding site [chemical binding]; other site 311403021244 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 311403021245 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 311403021246 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 311403021247 substrate binding site [chemical binding]; other site 311403021248 ATP binding site [chemical binding]; other site 311403021249 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 311403021250 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 311403021251 classical (c) SDRs; Region: SDR_c; cd05233 311403021252 NAD(P) binding site [chemical binding]; other site 311403021253 active site 311403021254 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 311403021255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 311403021256 active site 311403021257 motif I; other site 311403021258 motif II; other site 311403021259 MarR family; Region: MarR_2; pfam12802 311403021260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 311403021261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 311403021262 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 311403021263 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403021264 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 311403021265 putative ligand binding site [chemical binding]; other site 311403021266 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403021267 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403021268 TM-ABC transporter signature motif; other site 311403021269 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403021270 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403021271 Walker A/P-loop; other site 311403021272 ATP binding site [chemical binding]; other site 311403021273 Q-loop/lid; other site 311403021274 ABC transporter signature motif; other site 311403021275 Walker B; other site 311403021276 D-loop; other site 311403021277 H-loop/switch region; other site 311403021278 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403021279 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 311403021280 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 311403021281 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403021282 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403021283 Q-loop/lid; other site 311403021284 ABC transporter signature motif; other site 311403021285 Walker B; other site 311403021286 D-loop; other site 311403021287 H-loop/switch region; other site 311403021288 NMT1/THI5 like; Region: NMT1; pfam09084 311403021289 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021290 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021291 active site 311403021292 non-prolyl cis peptide bond; other site 311403021293 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403021294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021295 Walker A/P-loop; other site 311403021296 ATP binding site [chemical binding]; other site 311403021297 Q-loop/lid; other site 311403021298 ABC transporter signature motif; other site 311403021299 Walker B; other site 311403021300 D-loop; other site 311403021301 H-loop/switch region; other site 311403021302 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021303 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021304 Walker A/P-loop; other site 311403021305 ATP binding site [chemical binding]; other site 311403021306 Q-loop/lid; other site 311403021307 ABC transporter signature motif; other site 311403021308 Walker B; other site 311403021309 D-loop; other site 311403021310 H-loop/switch region; other site 311403021311 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021312 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403021313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021314 dimer interface [polypeptide binding]; other site 311403021315 conserved gate region; other site 311403021316 putative PBP binding loops; other site 311403021317 ABC-ATPase subunit interface; other site 311403021318 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021320 dimer interface [polypeptide binding]; other site 311403021321 conserved gate region; other site 311403021322 putative PBP binding loops; other site 311403021323 ABC-ATPase subunit interface; other site 311403021324 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021325 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 311403021326 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021327 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021328 active site 311403021329 non-prolyl cis peptide bond; other site 311403021330 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403021331 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403021332 active site 311403021333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403021334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403021335 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403021336 dimerization interface [polypeptide binding]; other site 311403021337 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 311403021338 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 311403021339 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 311403021340 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403021341 substrate binding pocket [chemical binding]; other site 311403021342 membrane-bound complex binding site; other site 311403021343 hinge residues; other site 311403021344 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 311403021345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021346 conserved gate region; other site 311403021347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021348 putative PBP binding loops; other site 311403021349 dimer interface [polypeptide binding]; other site 311403021350 ABC-ATPase subunit interface; other site 311403021351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021352 dimer interface [polypeptide binding]; other site 311403021353 conserved gate region; other site 311403021354 putative PBP binding loops; other site 311403021355 ABC-ATPase subunit interface; other site 311403021356 Predicted methyltransferase [General function prediction only]; Region: COG4798 311403021357 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021358 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021359 active site 311403021360 non-prolyl cis peptide bond; other site 311403021361 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403021362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403021363 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403021364 active site 311403021365 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021367 dimer interface [polypeptide binding]; other site 311403021368 conserved gate region; other site 311403021369 putative PBP binding loops; other site 311403021370 ABC-ATPase subunit interface; other site 311403021371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403021372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021373 dimer interface [polypeptide binding]; other site 311403021374 conserved gate region; other site 311403021375 putative PBP binding loops; other site 311403021376 ABC-ATPase subunit interface; other site 311403021377 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403021378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021379 Walker A/P-loop; other site 311403021380 ATP binding site [chemical binding]; other site 311403021381 Q-loop/lid; other site 311403021382 ABC transporter signature motif; other site 311403021383 Walker B; other site 311403021384 D-loop; other site 311403021385 H-loop/switch region; other site 311403021386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021387 Walker A/P-loop; other site 311403021388 ATP binding site [chemical binding]; other site 311403021389 Q-loop/lid; other site 311403021390 ABC transporter signature motif; other site 311403021391 Walker B; other site 311403021392 D-loop; other site 311403021393 H-loop/switch region; other site 311403021394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021395 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021396 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 311403021397 peptide binding site [polypeptide binding]; other site 311403021398 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021399 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 311403021400 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021402 dimer interface [polypeptide binding]; other site 311403021403 conserved gate region; other site 311403021404 putative PBP binding loops; other site 311403021405 ABC-ATPase subunit interface; other site 311403021406 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403021407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021408 dimer interface [polypeptide binding]; other site 311403021409 conserved gate region; other site 311403021410 putative PBP binding loops; other site 311403021411 ABC-ATPase subunit interface; other site 311403021412 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403021413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021414 Walker A/P-loop; other site 311403021415 ATP binding site [chemical binding]; other site 311403021416 Q-loop/lid; other site 311403021417 ABC transporter signature motif; other site 311403021418 Walker B; other site 311403021419 D-loop; other site 311403021420 H-loop/switch region; other site 311403021421 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021422 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021423 Walker A/P-loop; other site 311403021424 ATP binding site [chemical binding]; other site 311403021425 Q-loop/lid; other site 311403021426 ABC transporter signature motif; other site 311403021427 Walker B; other site 311403021428 D-loop; other site 311403021429 H-loop/switch region; other site 311403021430 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403021431 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403021432 dimer interface [polypeptide binding]; other site 311403021433 active site 311403021434 non-prolyl cis peptide bond; other site 311403021435 insertion regions; other site 311403021436 hypothetical protein; Provisional; Region: PRK01346 311403021437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403021438 Coenzyme A binding pocket [chemical binding]; other site 311403021439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403021440 uridine kinase; Validated; Region: PRK06696 311403021441 active site 311403021442 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 311403021443 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 311403021444 catalytic residues [active] 311403021445 catalytic nucleophile [active] 311403021446 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 311403021447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 311403021448 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 311403021449 IHF dimer interface [polypeptide binding]; other site 311403021450 IHF - DNA interface [nucleotide binding]; other site 311403021451 serine acetyltransferase; Provisional; Region: cysE; PRK11132 311403021452 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 311403021453 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 311403021454 trimer interface [polypeptide binding]; other site 311403021455 active site 311403021456 substrate binding site [chemical binding]; other site 311403021457 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 311403021458 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 311403021459 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 311403021460 Cupin domain; Region: Cupin_2; pfam07883 311403021461 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 311403021462 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 311403021463 dimer interface [polypeptide binding]; other site 311403021464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 311403021465 catalytic residue [active] 311403021466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 311403021467 EamA-like transporter family; Region: EamA; pfam00892 311403021468 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 311403021469 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 311403021470 acyl-activating enzyme (AAE) consensus motif; other site 311403021471 AMP binding site [chemical binding]; other site 311403021472 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 311403021473 NADPH bind site [chemical binding]; other site 311403021474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 311403021475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 311403021476 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 311403021477 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403021478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021479 Walker A/P-loop; other site 311403021480 ATP binding site [chemical binding]; other site 311403021481 Q-loop/lid; other site 311403021482 ABC transporter signature motif; other site 311403021483 Walker B; other site 311403021484 D-loop; other site 311403021485 H-loop/switch region; other site 311403021486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021487 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403021488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021489 dimer interface [polypeptide binding]; other site 311403021490 conserved gate region; other site 311403021491 putative PBP binding loops; other site 311403021492 ABC-ATPase subunit interface; other site 311403021493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021495 dimer interface [polypeptide binding]; other site 311403021496 conserved gate region; other site 311403021497 putative PBP binding loops; other site 311403021498 ABC-ATPase subunit interface; other site 311403021499 Transcriptional regulators [Transcription]; Region: FadR; COG2186 311403021500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 311403021501 DNA-binding site [nucleotide binding]; DNA binding site 311403021502 FCD domain; Region: FCD; pfam07729 311403021503 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403021504 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403021505 Walker A/P-loop; other site 311403021506 ATP binding site [chemical binding]; other site 311403021507 Q-loop/lid; other site 311403021508 ABC transporter signature motif; other site 311403021509 Walker B; other site 311403021510 D-loop; other site 311403021511 H-loop/switch region; other site 311403021512 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403021513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021514 dimer interface [polypeptide binding]; other site 311403021515 conserved gate region; other site 311403021516 putative PBP binding loops; other site 311403021517 ABC-ATPase subunit interface; other site 311403021518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021519 dimer interface [polypeptide binding]; other site 311403021520 conserved gate region; other site 311403021521 putative PBP binding loops; other site 311403021522 ABC-ATPase subunit interface; other site 311403021523 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 311403021524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403021525 substrate binding pocket [chemical binding]; other site 311403021526 membrane-bound complex binding site; other site 311403021527 hinge residues; other site 311403021528 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021529 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021530 active site 311403021531 non-prolyl cis peptide bond; other site 311403021532 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021533 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021534 active site 311403021535 non-prolyl cis peptide bond; other site 311403021536 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021537 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 311403021538 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 311403021539 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403021540 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 311403021541 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 311403021542 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 311403021543 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 311403021544 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 311403021545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 311403021546 Transposase; Region: HTH_Tnp_1; pfam01527 311403021547 hypothetical protein; Provisional; Region: PRK07206 311403021548 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 311403021549 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 311403021550 acyl-activating enzyme (AAE) consensus motif; other site 311403021551 active site 311403021552 AMP binding site [chemical binding]; other site 311403021553 CoA binding site [chemical binding]; other site 311403021554 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403021555 classical (c) SDRs; Region: SDR_c; cd05233 311403021556 NAD(P) binding site [chemical binding]; other site 311403021557 active site 311403021558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403021559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403021560 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 311403021561 dimerization interface [polypeptide binding]; other site 311403021562 substrate binding pocket [chemical binding]; other site 311403021563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 311403021564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 311403021565 putative substrate translocation pore; other site 311403021566 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 311403021567 Amidase; Region: Amidase; cl11426 311403021568 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 311403021569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403021570 Coenzyme A binding pocket [chemical binding]; other site 311403021571 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 311403021572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 311403021573 AMP binding site [chemical binding]; other site 311403021574 active site 311403021575 acyl-activating enzyme (AAE) consensus motif; other site 311403021576 CoA binding site [chemical binding]; other site 311403021577 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 311403021578 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 311403021579 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 311403021580 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1689 311403021581 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 311403021582 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 311403021583 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 311403021584 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 311403021585 acyl-activating enzyme (AAE) consensus motif; other site 311403021586 active site 311403021587 AMP binding site [chemical binding]; other site 311403021588 CoA binding site [chemical binding]; other site 311403021589 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 311403021590 Helix-turn-helix domain; Region: HTH_28; pfam13518 311403021591 Winged helix-turn helix; Region: HTH_29; pfam13551 311403021592 Homeodomain-like domain; Region: HTH_32; pfam13565 311403021593 transposase/IS protein; Provisional; Region: PRK09183 311403021594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403021595 Walker A motif; other site 311403021596 ATP binding site [chemical binding]; other site 311403021597 Walker B motif; other site 311403021598 arginine finger; other site 311403021599 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021600 active site 311403021601 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021602 non-prolyl cis peptide bond; other site 311403021603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403021604 substrate binding pocket [chemical binding]; other site 311403021605 membrane-bound complex binding site; other site 311403021606 hinge residues; other site 311403021607 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403021608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021609 dimer interface [polypeptide binding]; other site 311403021610 conserved gate region; other site 311403021611 putative PBP binding loops; other site 311403021612 ABC-ATPase subunit interface; other site 311403021613 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403021614 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403021615 Walker A/P-loop; other site 311403021616 ATP binding site [chemical binding]; other site 311403021617 Q-loop/lid; other site 311403021618 ABC transporter signature motif; other site 311403021619 Walker B; other site 311403021620 D-loop; other site 311403021621 H-loop/switch region; other site 311403021622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403021623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403021624 LysR substrate binding domain; Region: LysR_substrate; pfam03466 311403021625 dimerization interface [polypeptide binding]; other site 311403021626 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 311403021627 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 311403021628 active site residue [active] 311403021629 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 311403021630 active site residue [active] 311403021631 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 311403021632 active site residue [active] 311403021633 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 311403021634 active site residue [active] 311403021635 Cupin domain; Region: Cupin_2; cl17218 311403021636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403021637 Predicted amidohydrolase [General function prediction only]; Region: COG0388 311403021638 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 311403021639 active site 311403021640 dimer interface [polypeptide binding]; other site 311403021641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 311403021642 Winged helix-turn helix; Region: HTH_29; pfam13551 311403021643 Helix-turn-helix domain; Region: HTH_28; pfam13518 311403021644 DDE superfamily endonuclease; Region: DDE_3; pfam13358 311403021645 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 311403021646 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 311403021647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 311403021648 Coenzyme A binding pocket [chemical binding]; other site 311403021649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 311403021650 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 311403021651 DinB family; Region: DinB; cl17821 311403021652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 311403021653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 311403021654 Transcriptional regulators [Transcription]; Region: MarR; COG1846 311403021655 MarR family; Region: MarR_2; pfam12802 311403021656 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403021657 classical (c) SDRs; Region: SDR_c; cd05233 311403021658 NAD(P) binding site [chemical binding]; other site 311403021659 active site 311403021660 Uncharacterized conserved protein [Function unknown]; Region: COG4544 311403021661 DNA Polymerase Y-family; Region: PolY_like; cd03468 311403021662 active site 311403021663 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 311403021664 DNA binding site [nucleotide binding] 311403021665 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 311403021666 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 311403021667 putative active site [active] 311403021668 putative PHP Thumb interface [polypeptide binding]; other site 311403021669 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 311403021670 generic binding surface I; other site 311403021671 generic binding surface II; other site 311403021672 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 311403021673 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 311403021674 active site 311403021675 metal binding site [ion binding]; metal-binding site 311403021676 mobile mystery protein B; Region: mob_myst_B; TIGR02613 311403021677 Fic/DOC family; Region: Fic; pfam02661 311403021678 mobile mystery protein A; Region: mob_myst_A; TIGR02612 311403021679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 311403021680 non-specific DNA binding site [nucleotide binding]; other site 311403021681 salt bridge; other site 311403021682 sequence-specific DNA binding site [nucleotide binding]; other site 311403021683 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 311403021684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403021685 S-adenosylmethionine binding site [chemical binding]; other site 311403021686 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 311403021687 DEAD-like helicases superfamily; Region: DEXDc; smart00487 311403021688 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 311403021689 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 311403021690 helicase superfamily c-terminal domain; Region: HELICc; smart00490 311403021691 plasmid partitioning protein; Provisional; Region: PRK13832 311403021692 ParB-like nuclease domain; Region: ParB; smart00470 311403021693 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 311403021694 PhnA protein; Region: PhnA; pfam03831 311403021695 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 311403021696 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 311403021697 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 311403021698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403021699 S-adenosylmethionine binding site [chemical binding]; other site 311403021700 topology modulation protein; Reviewed; Region: PRK08118 311403021701 AAA domain; Region: AAA_17; pfam13207 311403021702 multiple promoter invertase; Provisional; Region: mpi; PRK13413 311403021703 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 311403021704 catalytic residues [active] 311403021705 catalytic nucleophile [active] 311403021706 Presynaptic Site I dimer interface [polypeptide binding]; other site 311403021707 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 311403021708 Synaptic Flat tetramer interface [polypeptide binding]; other site 311403021709 Synaptic Site I dimer interface [polypeptide binding]; other site 311403021710 DNA binding site [nucleotide binding] 311403021711 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 311403021712 DNA-binding interface [nucleotide binding]; DNA binding site 311403021713 TniQ; Region: TniQ; pfam06527 311403021714 Bacterial TniB protein; Region: TniB; pfam05621 311403021715 AAA domain; Region: AAA_22; pfam13401 311403021716 Helix-turn-helix domain; Region: HTH_28; pfam13518 311403021717 Integrase core domain; Region: rve; pfam00665 311403021718 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 311403021719 Methyltransferase domain; Region: Methyltransf_23; pfam13489 311403021720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403021721 S-adenosylmethionine binding site [chemical binding]; other site 311403021722 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 311403021723 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 311403021724 catalytic nucleophile [active] 311403021725 Synaptic Flat tetramer interface [polypeptide binding]; other site 311403021726 Synaptic Site I dimer interface [polypeptide binding]; other site 311403021727 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 311403021728 Presynaptic Site I dimer interface [polypeptide binding]; other site 311403021729 Uncharacterized conserved protein [Function unknown]; Region: COG5489 311403021730 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 311403021731 IHF dimer interface [polypeptide binding]; other site 311403021732 IHF - DNA interface [nucleotide binding]; other site 311403021733 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 311403021734 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 311403021735 Catalytic site; other site 311403021736 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 311403021737 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 311403021738 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 311403021739 Walker A motif; other site 311403021740 ATP binding site [chemical binding]; other site 311403021741 Walker B motif; other site 311403021742 conjugal transfer protein TraD; Provisional; Region: PRK13847 311403021743 conjugal transfer protein TraC; Provisional; Region: PRK13848 311403021744 Dtr system oriT relaxase; Provisional; Region: PRK13826 311403021745 MobA/MobL family; Region: MobA_MobL; pfam03389 311403021746 AAA domain; Region: AAA_30; pfam13604 311403021747 Family description; Region: UvrD_C_2; pfam13538 311403021748 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 311403021749 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 311403021750 conjugal transfer protein TraB; Provisional; Region: PRK13825 311403021751 active site 311403021752 catalytic triad [active] 311403021753 conjugal transfer protein TraH; Provisional; Region: PRK13843 311403021754 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403021755 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403021756 LysR substrate binding domain; Region: LysR_substrate; pfam03466 311403021757 dimerization interface [polypeptide binding]; other site 311403021758 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 311403021759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403021760 Walker A/P-loop; other site 311403021761 ATP binding site [chemical binding]; other site 311403021762 Q-loop/lid; other site 311403021763 ABC transporter signature motif; other site 311403021764 Walker B; other site 311403021765 D-loop; other site 311403021766 H-loop/switch region; other site 311403021767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021768 dimer interface [polypeptide binding]; other site 311403021769 conserved gate region; other site 311403021770 putative PBP binding loops; other site 311403021771 ABC-ATPase subunit interface; other site 311403021772 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 311403021773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403021774 substrate binding pocket [chemical binding]; other site 311403021775 membrane-bound complex binding site; other site 311403021776 hinge residues; other site 311403021777 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021778 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021779 active site 311403021780 non-prolyl cis peptide bond; other site 311403021781 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403021782 active site 311403021783 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403021784 non-prolyl cis peptide bond; other site 311403021785 Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228 311403021786 transcriptional regulator TraR; Provisional; Region: PRK13870 311403021787 Autoinducer binding domain; Region: Autoind_bind; pfam03472 311403021788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403021789 DNA binding residues [nucleotide binding] 311403021790 dimerization interface [polypeptide binding]; other site 311403021791 sucrose phosphorylase; Provisional; Region: PRK13840 311403021792 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 311403021793 active site 311403021794 homodimer interface [polypeptide binding]; other site 311403021795 catalytic site [active] 311403021796 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 311403021797 active site 311403021798 catalytic residues [active] 311403021799 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 311403021800 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 311403021801 PhoU domain; Region: PhoU; pfam01895 311403021802 PhoU domain; Region: PhoU; pfam01895 311403021803 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 311403021804 active site 311403021805 catalytic residues [active] 311403021806 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 311403021807 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 311403021808 AP (apurinic/apyrimidinic) site pocket; other site 311403021809 DNA interaction; other site 311403021810 Metal-binding active site; metal-binding site 311403021811 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 311403021812 nudix motif; other site 311403021813 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 311403021814 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 311403021815 active site 311403021816 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 311403021817 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 311403021818 active site 311403021819 catalytic site [active] 311403021820 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 311403021821 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 311403021822 active site 311403021823 catalytic site [active] 311403021824 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403021825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021826 dimer interface [polypeptide binding]; other site 311403021827 conserved gate region; other site 311403021828 putative PBP binding loops; other site 311403021829 ABC-ATPase subunit interface; other site 311403021830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021832 dimer interface [polypeptide binding]; other site 311403021833 conserved gate region; other site 311403021834 putative PBP binding loops; other site 311403021835 ABC-ATPase subunit interface; other site 311403021836 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403021837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021838 Walker A/P-loop; other site 311403021839 ATP binding site [chemical binding]; other site 311403021840 Q-loop/lid; other site 311403021841 ABC transporter signature motif; other site 311403021842 Walker B; other site 311403021843 D-loop; other site 311403021844 H-loop/switch region; other site 311403021845 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021846 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403021847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021848 Walker A/P-loop; other site 311403021849 ATP binding site [chemical binding]; other site 311403021850 Q-loop/lid; other site 311403021851 ABC transporter signature motif; other site 311403021852 Walker B; other site 311403021853 D-loop; other site 311403021854 H-loop/switch region; other site 311403021855 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021856 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 311403021857 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 311403021858 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403021859 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 311403021860 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403021861 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021862 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 311403021863 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 311403021864 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 311403021865 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 311403021866 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 311403021867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021868 dimer interface [polypeptide binding]; other site 311403021869 conserved gate region; other site 311403021870 putative PBP binding loops; other site 311403021871 ABC-ATPase subunit interface; other site 311403021872 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403021873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021874 dimer interface [polypeptide binding]; other site 311403021875 conserved gate region; other site 311403021876 putative PBP binding loops; other site 311403021877 ABC-ATPase subunit interface; other site 311403021878 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 311403021879 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 311403021880 active site 311403021881 catalytic site [active] 311403021882 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 311403021883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021884 Walker A/P-loop; other site 311403021885 ATP binding site [chemical binding]; other site 311403021886 Q-loop/lid; other site 311403021887 ABC transporter signature motif; other site 311403021888 Walker B; other site 311403021889 D-loop; other site 311403021890 H-loop/switch region; other site 311403021891 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 311403021892 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 311403021893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403021894 Walker A/P-loop; other site 311403021895 ATP binding site [chemical binding]; other site 311403021896 Q-loop/lid; other site 311403021897 ABC transporter signature motif; other site 311403021898 Walker B; other site 311403021899 D-loop; other site 311403021900 H-loop/switch region; other site 311403021901 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403021902 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403021903 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 311403021904 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 311403021905 catalytic core [active] 311403021906 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 311403021907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 311403021908 DNA binding residues [nucleotide binding] 311403021909 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 311403021910 transcriptional regulator TraR; Provisional; Region: PRK13870 311403021911 Autoinducer binding domain; Region: Autoind_bind; pfam03472 311403021912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 311403021913 DNA binding residues [nucleotide binding] 311403021914 dimerization interface [polypeptide binding]; other site 311403021915 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 311403021916 ornithine cyclodeaminase; Validated; Region: PRK07589 311403021917 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 311403021918 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 311403021919 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 311403021920 Arginase family; Region: Arginase; cd09989 311403021921 agmatinase; Region: agmatinase; TIGR01230 311403021922 active site 311403021923 Mn binding site [ion binding]; other site 311403021924 oligomer interface [polypeptide binding]; other site 311403021925 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 311403021926 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 311403021927 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 311403021928 hydroxyglutarate oxidase; Provisional; Region: PRK11728 311403021929 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 311403021930 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 311403021931 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 311403021932 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 311403021933 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 311403021934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403021935 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 311403021936 dimerization interface [polypeptide binding]; other site 311403021937 substrate binding pocket [chemical binding]; other site 311403021938 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403021939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021940 dimer interface [polypeptide binding]; other site 311403021941 conserved gate region; other site 311403021942 putative PBP binding loops; other site 311403021943 ABC-ATPase subunit interface; other site 311403021944 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 311403021945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403021946 dimer interface [polypeptide binding]; other site 311403021947 conserved gate region; other site 311403021948 putative PBP binding loops; other site 311403021949 ABC-ATPase subunit interface; other site 311403021950 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 311403021951 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403021952 substrate binding pocket [chemical binding]; other site 311403021953 membrane-bound complex binding site; other site 311403021954 hinge residues; other site 311403021955 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 311403021956 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 311403021957 Walker A/P-loop; other site 311403021958 ATP binding site [chemical binding]; other site 311403021959 Q-loop/lid; other site 311403021960 ABC transporter signature motif; other site 311403021961 Walker B; other site 311403021962 D-loop; other site 311403021963 H-loop/switch region; other site 311403021964 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 311403021965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403021966 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 311403021967 putative dimerization interface [polypeptide binding]; other site 311403021968 conjugal transfer protein TrbI; Provisional; Region: PRK13831 311403021969 conjugal transfer protein TrbH; Provisional; Region: PRK13835 311403021970 Conjugal transfer protein TrbH; Region: TrbH; pfam07283 311403021971 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 311403021972 VirB7 interaction site; other site 311403021973 conjugal transfer protein TrbF; Provisional; Region: PRK13836 311403021974 conjugal transfer protein TrbL; Provisional; Region: PRK13841 311403021975 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 311403021976 Protein of unknown function (DUF2749); Region: DUF2749; cl12488 311403021977 conjugal transfer protein TrbJ; Provisional; Region: PRK13842 311403021978 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 311403021979 conjugal transfer protein TrbE; Provisional; Region: PRK13830 311403021980 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 311403021981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403021982 Walker A/P-loop; other site 311403021983 ATP binding site [chemical binding]; other site 311403021984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403021985 Walker B; other site 311403021986 H-loop/switch region; other site 311403021987 conjugal transfer protein TrbD; Provisional; Region: PRK13823 311403021988 conjugal transfer protein TrbC; Provisional; Region: PRK13871 311403021989 conjugal transfer protein TrbB; Provisional; Region: PRK13833 311403021990 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 311403021991 ATP binding site [chemical binding]; other site 311403021992 Walker A motif; other site 311403021993 hexamer interface [polypeptide binding]; other site 311403021994 Walker B motif; other site 311403021995 putative autoinducer synthesis protein; Provisional; Region: PRK13834 311403021996 plasmid-partitioning protein RepA; Provisional; Region: PRK13869 311403021997 MerR family regulatory protein; Region: MerR; pfam00376 311403021998 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403021999 P-loop; other site 311403022000 Magnesium ion binding site [ion binding]; other site 311403022001 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 311403022002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403022003 Magnesium ion binding site [ion binding]; other site 311403022004 plasmid partitioning protein RepB; Provisional; Region: PRK13866 311403022005 ParB-like nuclease domain; Region: ParBc; pfam02195 311403022006 replication initiation protein RepC; Provisional; Region: PRK13824 311403022007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 311403022008 putative DNA binding site [nucleotide binding]; other site 311403022009 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 311403022010 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 311403022011 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 311403022012 catalytic residues [active] 311403022013 catalytic nucleophile [active] 311403022014 Presynaptic Site I dimer interface [polypeptide binding]; other site 311403022015 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 311403022016 Synaptic Flat tetramer interface [polypeptide binding]; other site 311403022017 Synaptic Site I dimer interface [polypeptide binding]; other site 311403022018 DNA binding site [nucleotide binding] 311403022019 Protein of unknown function (DUF1612); Region: DUF1612; pfam07756 311403022020 HTH DNA binding domain; Region: HTH_13; pfam11972 311403022021 Superfamily II helicase [General function prediction only]; Region: COG1204 311403022022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 311403022023 ATP binding site [chemical binding]; other site 311403022024 putative Mg++ binding site [ion binding]; other site 311403022025 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 311403022026 RES domain; Region: RES; pfam08808 311403022027 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 311403022028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403022029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 311403022030 dimerization interface [polypeptide binding]; other site 311403022031 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 311403022032 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 311403022033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403022034 dimer interface [polypeptide binding]; other site 311403022035 conserved gate region; other site 311403022036 putative PBP binding loops; other site 311403022037 ABC-ATPase subunit interface; other site 311403022038 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 311403022039 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 311403022040 Walker A/P-loop; other site 311403022041 ATP binding site [chemical binding]; other site 311403022042 Q-loop/lid; other site 311403022043 ABC transporter signature motif; other site 311403022044 Walker B; other site 311403022045 D-loop; other site 311403022046 H-loop/switch region; other site 311403022047 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 311403022048 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 311403022049 substrate binding pocket [chemical binding]; other site 311403022050 membrane-bound complex binding site; other site 311403022051 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403022052 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403022053 active site 311403022054 non-prolyl cis peptide bond; other site 311403022055 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 311403022056 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403022057 ligand binding site [chemical binding]; other site 311403022058 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403022059 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 311403022060 Walker A/P-loop; other site 311403022061 ATP binding site [chemical binding]; other site 311403022062 Q-loop/lid; other site 311403022063 ABC transporter signature motif; other site 311403022064 Walker B; other site 311403022065 D-loop; other site 311403022066 H-loop/switch region; other site 311403022067 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403022068 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403022069 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403022070 TM-ABC transporter signature motif; other site 311403022071 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 311403022072 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403022073 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403022074 active site 311403022075 non-prolyl cis peptide bond; other site 311403022076 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 311403022077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403022078 NAD(P) binding site [chemical binding]; other site 311403022079 active site 311403022080 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 311403022081 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 311403022082 haloalkane dehalogenase; Provisional; Region: PRK03592 311403022083 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 311403022084 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 311403022085 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 311403022086 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 311403022087 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 311403022088 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 311403022089 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 311403022090 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 311403022091 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 311403022092 TM-ABC transporter signature motif; other site 311403022093 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 311403022094 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 311403022095 Walker A/P-loop; other site 311403022096 ATP binding site [chemical binding]; other site 311403022097 Q-loop/lid; other site 311403022098 ABC transporter signature motif; other site 311403022099 Walker B; other site 311403022100 D-loop; other site 311403022101 H-loop/switch region; other site 311403022102 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 311403022103 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 311403022104 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 311403022105 ligand binding site [chemical binding]; other site 311403022106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 311403022107 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 311403022108 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 311403022109 Flavin binding site [chemical binding]; other site 311403022110 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 311403022111 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 311403022112 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 311403022113 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403022114 Walker A/P-loop; other site 311403022115 ATP binding site [chemical binding]; other site 311403022116 Q-loop/lid; other site 311403022117 ABC transporter signature motif; other site 311403022118 Walker B; other site 311403022119 D-loop; other site 311403022120 H-loop/switch region; other site 311403022121 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 311403022122 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 311403022123 Walker A/P-loop; other site 311403022124 ATP binding site [chemical binding]; other site 311403022125 Q-loop/lid; other site 311403022126 ABC transporter signature motif; other site 311403022127 Walker B; other site 311403022128 D-loop; other site 311403022129 H-loop/switch region; other site 311403022130 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 311403022131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403022132 dimer interface [polypeptide binding]; other site 311403022133 conserved gate region; other site 311403022134 putative PBP binding loops; other site 311403022135 ABC-ATPase subunit interface; other site 311403022136 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 311403022137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 311403022138 dimer interface [polypeptide binding]; other site 311403022139 conserved gate region; other site 311403022140 putative PBP binding loops; other site 311403022141 ABC-ATPase subunit interface; other site 311403022142 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 311403022143 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 311403022144 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 311403022145 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 311403022146 active site 311403022147 dimer interface [polypeptide binding]; other site 311403022148 non-prolyl cis peptide bond; other site 311403022149 insertion regions; other site 311403022150 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 311403022151 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 311403022152 active site 311403022153 non-prolyl cis peptide bond; other site 311403022154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 311403022155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 311403022156 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 311403022157 putative effector binding pocket; other site 311403022158 putative dimerization interface [polypeptide binding]; other site 311403022159 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 311403022160 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 311403022161 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 311403022162 Walker A motif; other site 311403022163 ATP binding site [chemical binding]; other site 311403022164 Walker B motif; other site 311403022165 arginine finger; other site 311403022166 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 311403022167 active site 311403022168 catalytic triad [active] 311403022169 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 311403022170 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 311403022171 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 311403022172 active site 311403022173 domain interfaces; other site 311403022174 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 311403022175 active site 311403022176 metal-binding site [ion binding] 311403022177 nucleotide-binding site [chemical binding]; other site 311403022178 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 311403022179 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 311403022180 classical (c) SDRs; Region: SDR_c; cd05233 311403022181 NAD(P) binding site [chemical binding]; other site 311403022182 active site 311403022183 Radical SAM superfamily; Region: Radical_SAM; pfam04055 311403022184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 311403022185 FeS/SAM binding site; other site 311403022186 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 311403022187 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 311403022188 putative dimer interface [polypeptide binding]; other site 311403022189 catalytic triad [active] 311403022190 Amidohydrolase; Region: Amidohydro_2; pfam04909 311403022191 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403022192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403022193 S-adenosylmethionine binding site [chemical binding]; other site 311403022194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 311403022195 classical (c) SDRs; Region: SDR_c; cd05233 311403022196 NAD(P) binding site [chemical binding]; other site 311403022197 active site 311403022198 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 311403022199 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 311403022200 HIGH motif; other site 311403022201 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 311403022202 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 311403022203 active site 311403022204 KMSKS motif; other site 311403022205 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 311403022206 tRNA binding surface [nucleotide binding]; other site 311403022207 Methyltransferase domain; Region: Methyltransf_31; pfam13847 311403022208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 311403022209 S-adenosylmethionine binding site [chemical binding]; other site 311403022210 asparagine synthetase A; Reviewed; Region: PRK06462 311403022211 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 311403022212 active site 311403022213 dimer interface [polypeptide binding]; other site 311403022214 motif 2; other site 311403022215 motif 3; other site 311403022216 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 311403022217 multiple promoter invertase; Provisional; Region: mpi; PRK13413 311403022218 catalytic residues [active] 311403022219 catalytic nucleophile [active] 311403022220 Presynaptic Site I dimer interface [polypeptide binding]; other site 311403022221 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 311403022222 Synaptic Flat tetramer interface [polypeptide binding]; other site 311403022223 Synaptic Site I dimer interface [polypeptide binding]; other site 311403022224 DNA binding site [nucleotide binding] 311403022225 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 311403022226 DNA-binding interface [nucleotide binding]; DNA binding site 311403022227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 311403022228 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 311403022229 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 311403022230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 311403022231 Walker A/P-loop; other site 311403022232 ATP binding site [chemical binding]; other site 311403022233 Q-loop/lid; other site 311403022234 ABC transporter signature motif; other site 311403022235 Walker B; other site 311403022236 D-loop; other site 311403022237 H-loop/switch region; other site 311403022238 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 311403022239 nudix motif; other site 311403022240 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_36; cd04695 311403022241 nudix motif; other site 311403022242 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 311403022243 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 311403022244 ParB-like nuclease domain; Region: ParB; smart00470 311403022245 Helix-turn-helix domain; Region: HTH_36; pfam13730 311403022246 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 311403022247 Magnesium ion binding site [ion binding]; other site 311403022248 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 311403022249 active site 311403022250 NTP binding site [chemical binding]; other site 311403022251 metal binding triad [ion binding]; metal-binding site 311403022252 Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748 311403022253 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 311403022254 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 311403022255 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 311403022256 Walker A motif; other site 311403022257 ATP binding site [chemical binding]; other site 311403022258 Walker B motif; other site 311403022259 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 311403022260 putative metal binding site [ion binding]; other site 311403022261 Uncharacterized conserved protein [Function unknown]; Region: COG1432 311403022262 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 311403022263 MobA/MobL family; Region: MobA_MobL; pfam03389 311403022264 AAA domain; Region: AAA_30; pfam13604 311403022265 Family description; Region: UvrD_C_2; pfam13538