-- dump date   	20140618_193054
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
176299000001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
176299000002	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
176299000003	active site
176299000004	dimer interface [polypeptide binding]; other site
176299000005	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
176299000006	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
176299000007	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
176299000008	shikimate binding site; other site
176299000009	NAD(P) binding site [chemical binding]; other site
176299000010	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
176299000011	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
176299000012	CoA-binding site [chemical binding]; other site
176299000013	ATP-binding [chemical binding]; other site
176299000014	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
176299000015	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
176299000016	active site
176299000017	catalytic site [active]
176299000018	substrate binding site [chemical binding]; other site
176299000019	preprotein translocase subunit SecB; Validated; Region: PRK05751
176299000020	SecA binding site; other site
176299000021	Preprotein binding site; other site
176299000022	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
176299000023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
176299000024	Tim44-like domain; Region: Tim44; pfam04280
176299000025	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
176299000026	MltA specific insert domain; Region: MltA; smart00925
176299000027	3D domain; Region: 3D; pfam06725
176299000028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
176299000029	Smr domain; Region: Smr; pfam01713
176299000030	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299000031	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299000032	non-specific DNA binding site [nucleotide binding]; other site
176299000033	salt bridge; other site
176299000034	sequence-specific DNA binding site [nucleotide binding]; other site
176299000035	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
176299000036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299000037	ATP binding site [chemical binding]; other site
176299000038	Mg2+ binding site [ion binding]; other site
176299000039	G-X-G motif; other site
176299000040	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
176299000041	anchoring element; other site
176299000042	dimer interface [polypeptide binding]; other site
176299000043	ATP binding site [chemical binding]; other site
176299000044	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
176299000045	active site
176299000046	putative metal-binding site [ion binding]; other site
176299000047	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
176299000048	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
176299000049	putative FMN binding site [chemical binding]; other site
176299000050	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
176299000051	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
176299000052	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
176299000053	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
176299000054	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
176299000055	active site
176299000056	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
176299000057	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299000058	catalytic residue [active]
176299000059	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
176299000060	substrate binding site [chemical binding]; other site
176299000061	active site
176299000062	catalytic residues [active]
176299000063	heterodimer interface [polypeptide binding]; other site
176299000064	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
176299000065	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
176299000066	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
176299000067	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
176299000068	catalytic residues [active]
176299000069	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
176299000070	Part of AAA domain; Region: AAA_19; pfam13245
176299000071	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
176299000072	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
176299000073	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
176299000074	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
176299000075	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
176299000076	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
176299000077	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
176299000078	Substrate binding site; other site
176299000079	metal-binding site
176299000080	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
176299000081	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
176299000082	Phosphotransferase enzyme family; Region: APH; pfam01636
176299000083	PAS fold; Region: PAS_7; pfam12860
176299000084	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
176299000085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299000086	dimer interface [polypeptide binding]; other site
176299000087	phosphorylation site [posttranslational modification]
176299000088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299000089	ATP binding site [chemical binding]; other site
176299000090	Mg2+ binding site [ion binding]; other site
176299000091	G-X-G motif; other site
176299000092	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
176299000093	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
176299000094	homotetramer interface [polypeptide binding]; other site
176299000095	ligand binding site [chemical binding]; other site
176299000096	catalytic site [active]
176299000097	NAD binding site [chemical binding]; other site
176299000098	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
176299000099	regulatory protein interface [polypeptide binding]; other site
176299000100	active site
176299000101	regulatory phosphorylation site [posttranslational modification]; other site
176299000102	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
176299000103	active pocket/dimerization site; other site
176299000104	active site
176299000105	phosphorylation site [posttranslational modification]
176299000106	Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493
176299000107	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
176299000108	Hpr binding site; other site
176299000109	active site
176299000110	homohexamer subunit interaction site [polypeptide binding]; other site
176299000111	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
176299000112	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
176299000113	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299000114	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299000115	dimerization interface [polypeptide binding]; other site
176299000116	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299000117	dimer interface [polypeptide binding]; other site
176299000118	phosphorylation site [posttranslational modification]
176299000119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299000120	ATP binding site [chemical binding]; other site
176299000121	Mg2+ binding site [ion binding]; other site
176299000122	G-X-G motif; other site
176299000123	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299000124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299000125	active site
176299000126	phosphorylation site [posttranslational modification]
176299000127	intermolecular recognition site; other site
176299000128	dimerization interface [polypeptide binding]; other site
176299000129	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299000130	DNA binding site [nucleotide binding]
176299000131	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
176299000132	active site
176299000133	substrate-binding site [chemical binding]; other site
176299000134	metal-binding site [ion binding]
176299000135	ATP binding site [chemical binding]; other site
176299000136	hypothetical protein; Provisional; Region: PRK09256
176299000137	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
176299000138	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
176299000139	ATP-binding site [chemical binding]; other site
176299000140	CoA-binding site [chemical binding]; other site
176299000141	Mg2+-binding site [ion binding]; other site
176299000142	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
176299000143	metal binding site [ion binding]; metal-binding site
176299000144	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
176299000145	substrate binding site [chemical binding]; other site
176299000146	glutamase interaction surface [polypeptide binding]; other site
176299000147	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
176299000148	catalytic residues [active]
176299000149	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
176299000150	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
176299000151	putative active site [active]
176299000152	oxyanion strand; other site
176299000153	catalytic triad [active]
176299000154	Protein of unknown function (DUF2628); Region: DUF2628; pfam10947
176299000155	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
176299000156	putative active site pocket [active]
176299000157	4-fold oligomerization interface [polypeptide binding]; other site
176299000158	metal binding residues [ion binding]; metal-binding site
176299000159	3-fold/trimer interface [polypeptide binding]; other site
176299000160	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
176299000161	active site
176299000162	HslU subunit interaction site [polypeptide binding]; other site
176299000163	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
176299000164	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299000165	Walker A motif; other site
176299000166	ATP binding site [chemical binding]; other site
176299000167	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
176299000168	Walker B motif; other site
176299000169	arginine finger; other site
176299000170	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
176299000171	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
176299000172	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
176299000173	active site
176299000174	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299000175	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299000176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5321
176299000177	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
176299000178	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299000179	active site
176299000180	phosphorylation site [posttranslational modification]
176299000181	intermolecular recognition site; other site
176299000182	dimerization interface [polypeptide binding]; other site
176299000183	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
176299000184	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299000185	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299000186	dimer interface [polypeptide binding]; other site
176299000187	phosphorylation site [posttranslational modification]
176299000188	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299000189	ATP binding site [chemical binding]; other site
176299000190	Mg2+ binding site [ion binding]; other site
176299000191	G-X-G motif; other site
176299000192	HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643
176299000193	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299000194	ATP binding site [chemical binding]; other site
176299000195	putative Mg++ binding site [ion binding]; other site
176299000196	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299000197	nucleotide binding region [chemical binding]; other site
176299000198	ATP-binding site [chemical binding]; other site
176299000199	Helicase associated domain (HA2); Region: HA2; pfam04408
176299000200	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
176299000201	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
176299000202	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299000203	ATP binding site [chemical binding]; other site
176299000204	putative Mg++ binding site [ion binding]; other site
176299000205	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299000206	nucleotide binding region [chemical binding]; other site
176299000207	ATP-binding site [chemical binding]; other site
176299000208	RQC domain; Region: RQC; pfam09382
176299000209	HRDC domain; Region: HRDC; pfam00570
176299000210	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
176299000211	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299000212	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
176299000213	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299000214	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
176299000215	ligand binding site [chemical binding]; other site
176299000216	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299000217	TM-ABC transporter signature motif; other site
176299000218	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
176299000219	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299000220	Walker A/P-loop; other site
176299000221	ATP binding site [chemical binding]; other site
176299000222	Q-loop/lid; other site
176299000223	ABC transporter signature motif; other site
176299000224	Walker B; other site
176299000225	D-loop; other site
176299000226	H-loop/switch region; other site
176299000227	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
176299000228	active site
176299000229	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
176299000230	catalytic residues [active]
176299000231	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
176299000232	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
176299000233	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
176299000234	Class I ribonucleotide reductase; Region: RNR_I; cd01679
176299000235	active site
176299000236	dimer interface [polypeptide binding]; other site
176299000237	catalytic residues [active]
176299000238	effector binding site; other site
176299000239	R2 peptide binding site; other site
176299000240	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
176299000241	dimer interface [polypeptide binding]; other site
176299000242	putative radical transfer pathway; other site
176299000243	diiron center [ion binding]; other site
176299000244	tyrosyl radical; other site
176299000245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
176299000246	recombination protein F; Reviewed; Region: recF; PRK00064
176299000247	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
176299000248	Walker A/P-loop; other site
176299000249	ATP binding site [chemical binding]; other site
176299000250	Q-loop/lid; other site
176299000251	ABC transporter signature motif; other site
176299000252	Walker B; other site
176299000253	D-loop; other site
176299000254	H-loop/switch region; other site
176299000255	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
176299000256	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
176299000257	ATP binding site [chemical binding]; other site
176299000258	substrate interface [chemical binding]; other site
176299000259	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299000260	Coenzyme A binding pocket [chemical binding]; other site
176299000261	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
176299000262	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
176299000263	dimerization interface [polypeptide binding]; other site
176299000264	ligand binding site [chemical binding]; other site
176299000265	NADP binding site [chemical binding]; other site
176299000266	catalytic site [active]
176299000267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
176299000268	Bacterial SH3 domain; Region: SH3_4; pfam06347
176299000269	Bacterial SH3 domain; Region: SH3_4; pfam06347
176299000270	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
176299000271	adenosine kinase; Provisional; Region: PTZ00247
176299000272	substrate binding site [chemical binding]; other site
176299000273	ATP binding site [chemical binding]; other site
176299000274	Predicted permeases [General function prediction only]; Region: COG0679
176299000275	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
176299000276	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299000277	S-adenosylmethionine binding site [chemical binding]; other site
176299000278	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
176299000279	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
176299000280	RNase E interface [polypeptide binding]; other site
176299000281	trimer interface [polypeptide binding]; other site
176299000282	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
176299000283	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
176299000284	RNase E interface [polypeptide binding]; other site
176299000285	trimer interface [polypeptide binding]; other site
176299000286	active site
176299000287	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
176299000288	putative nucleic acid binding region [nucleotide binding]; other site
176299000289	G-X-X-G motif; other site
176299000290	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
176299000291	RNA binding site [nucleotide binding]; other site
176299000292	domain interface; other site
176299000293	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
176299000294	16S/18S rRNA binding site [nucleotide binding]; other site
176299000295	S13e-L30e interaction site [polypeptide binding]; other site
176299000296	25S rRNA binding site [nucleotide binding]; other site
176299000297	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
176299000298	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
176299000299	RNA binding site [nucleotide binding]; other site
176299000300	active site
176299000301	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
176299000302	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
176299000303	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
176299000304	translation initiation factor IF-2; Validated; Region: infB; PRK05306
176299000305	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
176299000306	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
176299000307	G1 box; other site
176299000308	putative GEF interaction site [polypeptide binding]; other site
176299000309	GTP/Mg2+ binding site [chemical binding]; other site
176299000310	Switch I region; other site
176299000311	G2 box; other site
176299000312	G3 box; other site
176299000313	Switch II region; other site
176299000314	G4 box; other site
176299000315	G5 box; other site
176299000316	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
176299000317	Translation-initiation factor 2; Region: IF-2; pfam11987
176299000318	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
176299000319	hypothetical protein; Provisional; Region: PRK09190
176299000320	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
176299000321	putative RNA binding cleft [nucleotide binding]; other site
176299000322	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
176299000323	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
176299000324	NusA N-terminal domain; Region: NusA_N; pfam08529
176299000325	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
176299000326	RNA binding site [nucleotide binding]; other site
176299000327	homodimer interface [polypeptide binding]; other site
176299000328	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
176299000329	G-X-X-G motif; other site
176299000330	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
176299000331	G-X-X-G motif; other site
176299000332	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
176299000333	Sm and related proteins; Region: Sm_like; cl00259
176299000334	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
176299000335	putative oligomer interface [polypeptide binding]; other site
176299000336	putative RNA binding site [nucleotide binding]; other site
176299000337	Transmembrane secretion effector; Region: MFS_3; pfam05977
176299000338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299000339	putative substrate translocation pore; other site
176299000340	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
176299000341	Transglycosylase SLT domain; Region: SLT_2; pfam13406
176299000342	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299000343	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299000344	catalytic residue [active]
176299000345	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299000346	recombination protein RecR; Reviewed; Region: recR; PRK00076
176299000347	RecR protein; Region: RecR; pfam02132
176299000348	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
176299000349	putative active site [active]
176299000350	putative metal-binding site [ion binding]; other site
176299000351	tetramer interface [polypeptide binding]; other site
176299000352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
176299000353	MOSC domain; Region: MOSC; pfam03473
176299000354	hypothetical protein; Validated; Region: PRK00153
176299000355	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
176299000356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299000357	Walker A motif; other site
176299000358	ATP binding site [chemical binding]; other site
176299000359	Walker B motif; other site
176299000360	arginine finger; other site
176299000361	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
176299000362	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
176299000363	Bacterial signal recognition particle RNA SRP_bact; predicted by RFAM
176299000364	HIT domain; Region: HIT; pfam01230
176299000365	nucleotide binding site/active site [active]
176299000366	HIT family signature motif; other site
176299000367	catalytic residue [active]
176299000368	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
176299000369	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
176299000370	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
176299000371	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
176299000372	putative NADH binding site [chemical binding]; other site
176299000373	putative active site [active]
176299000374	nudix motif; other site
176299000375	putative metal binding site [ion binding]; other site
176299000376	prephenate dehydratase; Provisional; Region: PRK11899
176299000377	Prephenate dehydratase; Region: PDT; pfam00800
176299000378	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
176299000379	putative L-Phe binding site [chemical binding]; other site
176299000380	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
176299000381	Ligand binding site; other site
176299000382	oligomer interface; other site
176299000383	Cytochrome c2 [Energy production and conversion]; Region: COG3474
176299000384	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
176299000385	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
176299000386	Transglycosylase; Region: Transgly; pfam00912
176299000387	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
176299000388	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
176299000389	putative deacylase active site [active]
176299000390	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
176299000391	DNA-binding site [nucleotide binding]; DNA binding site
176299000392	RNA-binding motif; other site
176299000393	hypothetical protein; Validated; Region: PRK09104
176299000394	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
176299000395	metal binding site [ion binding]; metal-binding site
176299000396	putative dimer interface [polypeptide binding]; other site
176299000397	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299000398	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299000399	DNA polymerase I; Provisional; Region: PRK05755
176299000400	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
176299000401	active site
176299000402	metal binding site 1 [ion binding]; metal-binding site
176299000403	putative 5' ssDNA interaction site; other site
176299000404	metal binding site 3; metal-binding site
176299000405	metal binding site 2 [ion binding]; metal-binding site
176299000406	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
176299000407	putative DNA binding site [nucleotide binding]; other site
176299000408	putative metal binding site [ion binding]; other site
176299000409	Protein of unknown function (DUF1319); Region: DUF1319; pfam07028
176299000410	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
176299000411	active site
176299000412	catalytic site [active]
176299000413	substrate binding site [chemical binding]; other site
176299000414	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
176299000415	active site
176299000416	DNA binding site [nucleotide binding]
176299000417	catalytic site [active]
176299000418	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
176299000419	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
176299000420	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
176299000421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299000422	dimer interface [polypeptide binding]; other site
176299000423	phosphorylation site [posttranslational modification]
176299000424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299000425	ATP binding site [chemical binding]; other site
176299000426	Mg2+ binding site [ion binding]; other site
176299000427	G-X-G motif; other site
176299000428	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
176299000429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299000430	active site
176299000431	phosphorylation site [posttranslational modification]
176299000432	intermolecular recognition site; other site
176299000433	dimerization interface [polypeptide binding]; other site
176299000434	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299000435	Walker A motif; other site
176299000436	ATP binding site [chemical binding]; other site
176299000437	Walker B motif; other site
176299000438	arginine finger; other site
176299000439	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
176299000440	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
176299000441	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
176299000442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
176299000443	hypothetical protein; Provisional; Region: PRK00736
176299000444	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3803
176299000445	chaperone protein DnaJ; Provisional; Region: PRK10767
176299000446	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
176299000447	HSP70 interaction site [polypeptide binding]; other site
176299000448	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
176299000449	substrate binding site [polypeptide binding]; other site
176299000450	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
176299000451	Zn binding sites [ion binding]; other site
176299000452	dimer interface [polypeptide binding]; other site
176299000453	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
176299000454	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
176299000455	nucleotide binding site [chemical binding]; other site
176299000456	NEF interaction site [polypeptide binding]; other site
176299000457	SBD interface [polypeptide binding]; other site
176299000458	YopD protein; Region: YopD; pfam05844
176299000459	methionine sulfoxide reductase A; Provisional; Region: PRK00058
176299000460	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
176299000461	ligand binding site [chemical binding]; other site
176299000462	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
176299000463	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299000464	Walker A/P-loop; other site
176299000465	ATP binding site [chemical binding]; other site
176299000466	Q-loop/lid; other site
176299000467	ABC transporter signature motif; other site
176299000468	Walker B; other site
176299000469	D-loop; other site
176299000470	H-loop/switch region; other site
176299000471	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299000472	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
176299000473	TM-ABC transporter signature motif; other site
176299000474	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
176299000475	TM-ABC transporter signature motif; other site
176299000476	Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295
176299000477	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
176299000478	active site
176299000479	catalytic motif [active]
176299000480	Zn binding site [ion binding]; other site
176299000481	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
176299000482	purine nucleoside phosphorylase; Provisional; Region: PRK08202
176299000483	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
176299000484	intersubunit interface [polypeptide binding]; other site
176299000485	active site
176299000486	catalytic residue [active]
176299000487	thymidine phosphorylase; Region: T_phosphoryl; TIGR02643
176299000488	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
176299000489	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
176299000490	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
176299000491	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
176299000492	catalytic motif [active]
176299000493	Catalytic residue [active]
176299000494	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299000495	active site
176299000496	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
176299000497	active site
176299000498	purine riboside binding site [chemical binding]; other site
176299000499	phosphopentomutase; Provisional; Region: PRK05362
176299000500	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
176299000501	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
176299000502	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
176299000503	Subunit I/III interface [polypeptide binding]; other site
176299000504	Subunit III/IV interface [polypeptide binding]; other site
176299000505	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
176299000506	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
176299000507	D-pathway; other site
176299000508	Putative ubiquinol binding site [chemical binding]; other site
176299000509	Low-spin heme (heme b) binding site [chemical binding]; other site
176299000510	Putative water exit pathway; other site
176299000511	Binuclear center (heme o3/CuB) [ion binding]; other site
176299000512	K-pathway; other site
176299000513	Putative proton exit pathway; other site
176299000514	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
176299000515	The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212
176299000516	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
176299000517	metabolite-proton symporter; Region: 2A0106; TIGR00883
176299000518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299000519	putative substrate translocation pore; other site
176299000520	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
176299000521	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
176299000522	dimer interface [polypeptide binding]; other site
176299000523	active site
176299000524	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
176299000525	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
176299000526	active site
176299000527	FMN binding site [chemical binding]; other site
176299000528	substrate binding site [chemical binding]; other site
176299000529	3Fe-4S cluster binding site [ion binding]; other site
176299000530	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
176299000531	domain interface; other site
176299000532	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
176299000533	Flavodoxin; Region: Flavodoxin_1; pfam00258
176299000534	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
176299000535	FAD binding pocket [chemical binding]; other site
176299000536	FAD binding motif [chemical binding]; other site
176299000537	catalytic residues [active]
176299000538	NAD binding pocket [chemical binding]; other site
176299000539	phosphate binding motif [ion binding]; other site
176299000540	beta-alpha-beta structure motif; other site
176299000541	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
176299000542	TadE-like protein; Region: TadE; pfam07811
176299000543	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
176299000544	TadE-like protein; Region: TadE; pfam07811
176299000545	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
176299000546	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
176299000547	NAD binding site [chemical binding]; other site
176299000548	homotetramer interface [polypeptide binding]; other site
176299000549	homodimer interface [polypeptide binding]; other site
176299000550	substrate binding site [chemical binding]; other site
176299000551	active site
176299000552	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
176299000553	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
176299000554	dimer interface [polypeptide binding]; other site
176299000555	active site
176299000556	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
176299000557	active site 1 [active]
176299000558	dimer interface [polypeptide binding]; other site
176299000559	active site 2 [active]
176299000560	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
176299000561	metal binding site 2 [ion binding]; metal-binding site
176299000562	putative DNA binding helix; other site
176299000563	metal binding site 1 [ion binding]; metal-binding site
176299000564	dimer interface [polypeptide binding]; other site
176299000565	Predicted membrane protein [Function unknown]; Region: COG2860
176299000566	UPF0126 domain; Region: UPF0126; pfam03458
176299000567	UPF0126 domain; Region: UPF0126; pfam03458
176299000568	Predicted membrane protein [Function unknown]; Region: COG3619
176299000569	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299000570	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299000571	substrate binding pocket [chemical binding]; other site
176299000572	membrane-bound complex binding site; other site
176299000573	hinge residues; other site
176299000574	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299000575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299000576	dimer interface [polypeptide binding]; other site
176299000577	conserved gate region; other site
176299000578	putative PBP binding loops; other site
176299000579	ABC-ATPase subunit interface; other site
176299000580	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299000581	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299000582	Walker A/P-loop; other site
176299000583	ATP binding site [chemical binding]; other site
176299000584	Q-loop/lid; other site
176299000585	ABC transporter signature motif; other site
176299000586	Walker B; other site
176299000587	D-loop; other site
176299000588	H-loop/switch region; other site
176299000589	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
176299000590	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299000591	DNA-binding site [nucleotide binding]; DNA binding site
176299000592	UTRA domain; Region: UTRA; pfam07702
176299000593	DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625
176299000594	Merozoite surface antigen 2c; Region: MSA-2c; pfam12238
176299000595	tonB-system energizer ExbB; Region: exbB; TIGR02797
176299000596	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
176299000597	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
176299000598	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
176299000599	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
176299000600	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
176299000601	DNA binding residues [nucleotide binding]
176299000602	dimerization interface [polypeptide binding]; other site
176299000603	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
176299000604	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299000605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299000606	Uncharacterized component of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3709
176299000607	Guanylate kinase; Region: Guanylate_kin; pfam00625
176299000608	active site
176299000609	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
176299000610	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
176299000611	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
176299000612	active site
176299000613	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
176299000614	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
176299000615	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299000616	dimer interface [polypeptide binding]; other site
176299000617	conserved gate region; other site
176299000618	ABC-ATPase subunit interface; other site
176299000619	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
176299000620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299000621	dimer interface [polypeptide binding]; other site
176299000622	conserved gate region; other site
176299000623	ABC-ATPase subunit interface; other site
176299000624	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
176299000625	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299000626	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
176299000627	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
176299000628	Walker A/P-loop; other site
176299000629	ATP binding site [chemical binding]; other site
176299000630	Q-loop/lid; other site
176299000631	ABC transporter signature motif; other site
176299000632	Walker B; other site
176299000633	D-loop; other site
176299000634	H-loop/switch region; other site
176299000635	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
176299000636	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
176299000637	trimer interface [polypeptide binding]; other site
176299000638	active site
176299000639	substrate binding site [chemical binding]; other site
176299000640	CoA binding site [chemical binding]; other site
176299000641	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
176299000642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299000643	Walker A/P-loop; other site
176299000644	ATP binding site [chemical binding]; other site
176299000645	Q-loop/lid; other site
176299000646	ABC transporter signature motif; other site
176299000647	Walker B; other site
176299000648	D-loop; other site
176299000649	H-loop/switch region; other site
176299000650	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
176299000651	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299000652	Walker A/P-loop; other site
176299000653	ATP binding site [chemical binding]; other site
176299000654	Q-loop/lid; other site
176299000655	ABC transporter signature motif; other site
176299000656	Walker B; other site
176299000657	D-loop; other site
176299000658	H-loop/switch region; other site
176299000659	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299000660	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
176299000661	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
176299000662	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625
176299000663	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624
176299000664	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
176299000665	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299000666	DNA-binding site [nucleotide binding]; DNA binding site
176299000667	UTRA domain; Region: UTRA; pfam07702
176299000668	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
176299000669	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
176299000670	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
176299000671	Glucokinase [Carbohydrate transport and metabolism]; Region: Glk; COG0837
176299000672	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
176299000673	active site
176299000674	dimer interfaces [polypeptide binding]; other site
176299000675	catalytic residues [active]
176299000676	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
176299000677	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
176299000678	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
176299000679	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
176299000680	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
176299000681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299000682	dimer interface [polypeptide binding]; other site
176299000683	conserved gate region; other site
176299000684	putative PBP binding loops; other site
176299000685	ABC-ATPase subunit interface; other site
176299000686	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
176299000687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299000688	dimer interface [polypeptide binding]; other site
176299000689	conserved gate region; other site
176299000690	putative PBP binding loops; other site
176299000691	ABC-ATPase subunit interface; other site
176299000692	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
176299000693	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299000694	Walker A/P-loop; other site
176299000695	ATP binding site [chemical binding]; other site
176299000696	Q-loop/lid; other site
176299000697	ABC transporter signature motif; other site
176299000698	Walker B; other site
176299000699	D-loop; other site
176299000700	H-loop/switch region; other site
176299000701	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299000702	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299000703	Walker A/P-loop; other site
176299000704	ATP binding site [chemical binding]; other site
176299000705	Q-loop/lid; other site
176299000706	ABC transporter signature motif; other site
176299000707	Walker B; other site
176299000708	D-loop; other site
176299000709	H-loop/switch region; other site
176299000710	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299000711	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
176299000712	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
176299000713	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299000714	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299000715	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
176299000716	AAA domain; Region: AAA_33; pfam13671
176299000717	ATP-binding site [chemical binding]; other site
176299000718	Gluconate-6-phosphate binding site [chemical binding]; other site
176299000719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299000720	dimer interface [polypeptide binding]; other site
176299000721	conserved gate region; other site
176299000722	putative PBP binding loops; other site
176299000723	ABC-ATPase subunit interface; other site
176299000724	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
176299000725	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299000726	Walker A/P-loop; other site
176299000727	ATP binding site [chemical binding]; other site
176299000728	Q-loop/lid; other site
176299000729	ABC transporter signature motif; other site
176299000730	Walker B; other site
176299000731	D-loop; other site
176299000732	H-loop/switch region; other site
176299000733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299000734	dimer interface [polypeptide binding]; other site
176299000735	conserved gate region; other site
176299000736	putative PBP binding loops; other site
176299000737	ABC-ATPase subunit interface; other site
176299000738	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
176299000739	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
176299000740	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
176299000741	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
176299000742	iron-responsive transcriptional regulator; Reviewed; Region: rirA; PRK11920
176299000743	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299000744	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299000745	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
176299000746	Predicted membrane protein [Function unknown]; Region: COG4269
176299000747	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
176299000748	tetrameric interface [polypeptide binding]; other site
176299000749	NAD binding site [chemical binding]; other site
176299000750	catalytic residues [active]
176299000751	Uncharacterized conserved protein [Function unknown]; Region: COG1359
176299000752	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299000753	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299000754	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299000755	dimerization interface [polypeptide binding]; other site
176299000756	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299000757	EamA-like transporter family; Region: EamA; pfam00892
176299000758	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2899
176299000759	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299000760	MarR family; Region: MarR_2; pfam12802
176299000761	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
176299000762	NlpC/P60 family; Region: NLPC_P60; cl17555
176299000763	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
176299000764	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
176299000765	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
176299000766	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
176299000767	interface (dimer of trimers) [polypeptide binding]; other site
176299000768	Substrate-binding/catalytic site; other site
176299000769	Zn-binding sites [ion binding]; other site
176299000770	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
176299000771	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299000772	binding surface
176299000773	TPR motif; other site
176299000774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299000775	binding surface
176299000776	TPR motif; other site
176299000777	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
176299000778	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
176299000779	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
176299000780	ATP binding site [chemical binding]; other site
176299000781	Walker A motif; other site
176299000782	hexamer interface [polypeptide binding]; other site
176299000783	Walker B motif; other site
176299000784	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
176299000785	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
176299000786	Type IV pili component [Cell motility and secretion]; Region: COG5461
176299000787	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
176299000788	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
176299000789	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
176299000790	BON domain; Region: BON; pfam04972
176299000791	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
176299000792	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
176299000793	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
176299000794	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
176299000795	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
176299000796	Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526
176299000797	Predicted membrane protein [Function unknown]; Region: COG2259
176299000798	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
176299000799	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
176299000800	catalytic triad [active]
176299000801	Uncharacterized conserved protein [Function unknown]; Region: COG3422
176299000802	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
176299000803	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
176299000804	active site
176299000805	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299000806	EamA-like transporter family; Region: EamA; pfam00892
176299000807	EamA-like transporter family; Region: EamA; pfam00892
176299000808	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
176299000809	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299000810	DNA-binding site [nucleotide binding]; DNA binding site
176299000811	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299000812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299000813	homodimer interface [polypeptide binding]; other site
176299000814	catalytic residue [active]
176299000815	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
176299000816	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299000817	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
176299000818	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
176299000819	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
176299000820	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299000821	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299000822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4954
176299000823	GTP-binding protein LepA; Provisional; Region: PRK05433
176299000824	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
176299000825	G1 box; other site
176299000826	putative GEF interaction site [polypeptide binding]; other site
176299000827	GTP/Mg2+ binding site [chemical binding]; other site
176299000828	Switch I region; other site
176299000829	G2 box; other site
176299000830	G3 box; other site
176299000831	Switch II region; other site
176299000832	G4 box; other site
176299000833	G5 box; other site
176299000834	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
176299000835	Elongation Factor G, domain II; Region: EFG_II; pfam14492
176299000836	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
176299000837	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
176299000838	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
176299000839	putative active site [active]
176299000840	catalytic triad [active]
176299000841	putative dimer interface [polypeptide binding]; other site
176299000842	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299000843	Coenzyme A binding pocket [chemical binding]; other site
176299000844	Autoinducer binding domain; Region: Autoind_bind; pfam03472
176299000845	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
176299000846	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299000847	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299000848	non-specific DNA binding site [nucleotide binding]; other site
176299000849	salt bridge; other site
176299000850	sequence-specific DNA binding site [nucleotide binding]; other site
176299000851	Cupin domain; Region: Cupin_2; pfam07883
176299000852	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299000853	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299000854	Coenzyme A binding pocket [chemical binding]; other site
176299000855	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
176299000856	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
176299000857	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299000858	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
176299000859	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
176299000860	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
176299000861	apolar tunnel; other site
176299000862	heme binding site [chemical binding]; other site
176299000863	dimerization interface [polypeptide binding]; other site
176299000864	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
176299000865	diiron binding motif [ion binding]; other site
176299000866	CCC1-related protein family; Region: CCC1_like_1; cd02437
176299000867	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: Peptidase_C93; pfam06035
176299000868	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
176299000869	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299000870	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
176299000871	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
176299000872	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
176299000873	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
176299000874	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
176299000875	23S rRNA binding site [nucleotide binding]; other site
176299000876	L21 binding site [polypeptide binding]; other site
176299000877	L13 binding site [polypeptide binding]; other site
176299000878	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
176299000879	active site
176299000880	ATP binding site [chemical binding]; other site
176299000881	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
176299000882	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
176299000883	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
176299000884	dimer interface [polypeptide binding]; other site
176299000885	motif 1; other site
176299000886	active site
176299000887	motif 2; other site
176299000888	motif 3; other site
176299000889	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
176299000890	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
176299000891	putative tRNA-binding site [nucleotide binding]; other site
176299000892	B3/4 domain; Region: B3_4; pfam03483
176299000893	tRNA synthetase B5 domain; Region: B5; smart00874
176299000894	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
176299000895	dimer interface [polypeptide binding]; other site
176299000896	motif 1; other site
176299000897	motif 3; other site
176299000898	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
176299000899	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299000900	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299000901	active site
176299000902	catalytic tetrad [active]
176299000903	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299000904	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299000905	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
176299000906	putative effector binding pocket; other site
176299000907	putative dimerization interface [polypeptide binding]; other site
176299000908	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299000909	Coenzyme A binding pocket [chemical binding]; other site
176299000910	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299000911	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299000912	active site
176299000913	catalytic tetrad [active]
176299000914	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
176299000915	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
176299000916	conserved cys residue [active]
176299000917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299000918	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
176299000919	catalytic triad [active]
176299000920	conserved cis-peptide bond; other site
176299000921	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299000922	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299000923	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299000924	GtrA-like protein; Region: GtrA; cl19823
176299000925	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
176299000926	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
176299000927	generic binding surface II; other site
176299000928	generic binding surface I; other site
176299000929	Phosphoenolpyruvate carboxylase; Region: PEPcase_2; cl17501
176299000930	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299000931	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
176299000932	active site pocket [active]
176299000933	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299000934	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299000935	DNA-binding site [nucleotide binding]; DNA binding site
176299000936	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299000937	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299000938	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
176299000939	EamA-like transporter family; Region: EamA; pfam00892
176299000940	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
176299000941	EamA-like transporter family; Region: EamA; pfam00892
176299000942	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
176299000943	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
176299000944	putative deacylase active site [active]
176299000945	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
176299000946	putative catalytic residues [active]
176299000947	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
176299000948	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
176299000949	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299000950	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299000951	GMP synthase; Reviewed; Region: guaA; PRK00074
176299000952	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
176299000953	AMP/PPi binding site [chemical binding]; other site
176299000954	candidate oxyanion hole; other site
176299000955	catalytic triad [active]
176299000956	potential glutamine specificity residues [chemical binding]; other site
176299000957	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
176299000958	ATP Binding subdomain [chemical binding]; other site
176299000959	Ligand Binding sites [chemical binding]; other site
176299000960	Dimerization subdomain; other site
176299000961	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705
176299000962	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
176299000963	CoenzymeA binding site [chemical binding]; other site
176299000964	subunit interaction site [polypeptide binding]; other site
176299000965	PHB binding site; other site
176299000966	TspO/MBR family; Region: TspO_MBR; pfam03073
176299000967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3490
176299000968	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG3489
176299000969	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
176299000970	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
176299000971	Uncharacterized iron-regulated protein [Inorganic ion transport and metabolism]; Region: IrpA; COG3487
176299000972	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
176299000973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299000974	S-adenosylmethionine binding site [chemical binding]; other site
176299000975	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
176299000976	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
176299000977	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299000978	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
176299000979	putative NAD(P) binding site [chemical binding]; other site
176299000980	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
176299000981	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
176299000982	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
176299000983	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299000984	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
176299000985	C-terminal domain interface [polypeptide binding]; other site
176299000986	GSH binding site (G-site) [chemical binding]; other site
176299000987	dimer interface [polypeptide binding]; other site
176299000988	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
176299000989	N-terminal domain interface [polypeptide binding]; other site
176299000990	dimer interface [polypeptide binding]; other site
176299000991	substrate binding pocket (H-site) [chemical binding]; other site
176299000992	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
176299000993	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
176299000994	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
176299000995	putative NAD(P) binding site [chemical binding]; other site
176299000996	active site
176299000997	Uncharacterized conserved protein [Function unknown]; Region: COG5470
176299000998	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
176299000999	active site
176299001000	dimer interface [polypeptide binding]; other site
176299001001	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
176299001002	catalytic core [active]
176299001003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299001004	S-adenosylmethionine binding site [chemical binding]; other site
176299001005	DNA polymerase III subunit beta; Validated; Region: PRK05643
176299001006	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
176299001007	putative DNA binding surface [nucleotide binding]; other site
176299001008	dimer interface [polypeptide binding]; other site
176299001009	beta-clamp/clamp loader binding surface; other site
176299001010	beta-clamp/translesion DNA polymerase binding surface; other site
176299001011	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
176299001012	putative SAM binding site [chemical binding]; other site
176299001013	putative homodimer interface [polypeptide binding]; other site
176299001014	hypothetical protein; Reviewed; Region: PRK12497
176299001015	maltose O-acetyltransferase; Provisional; Region: PRK10092
176299001016	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
176299001017	active site
176299001018	substrate binding site [chemical binding]; other site
176299001019	trimer interface [polypeptide binding]; other site
176299001020	CoA binding site [chemical binding]; other site
176299001021	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299001022	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
176299001023	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299001024	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001025	dimer interface [polypeptide binding]; other site
176299001026	conserved gate region; other site
176299001027	putative PBP binding loops; other site
176299001028	ABC-ATPase subunit interface; other site
176299001029	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299001030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001031	dimer interface [polypeptide binding]; other site
176299001032	conserved gate region; other site
176299001033	putative PBP binding loops; other site
176299001034	ABC-ATPase subunit interface; other site
176299001035	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299001036	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299001037	Walker A/P-loop; other site
176299001038	ATP binding site [chemical binding]; other site
176299001039	Q-loop/lid; other site
176299001040	ABC transporter signature motif; other site
176299001041	Walker B; other site
176299001042	D-loop; other site
176299001043	H-loop/switch region; other site
176299001044	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
176299001045	glutathione synthetase; Provisional; Region: PRK05246
176299001046	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
176299001047	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
176299001048	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
176299001049	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
176299001050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299001051	Walker A motif; other site
176299001052	ATP binding site [chemical binding]; other site
176299001053	Walker B motif; other site
176299001054	arginine finger; other site
176299001055	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
176299001056	cysteine synthase; Region: PLN02565
176299001057	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
176299001058	dimer interface [polypeptide binding]; other site
176299001059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299001060	catalytic residue [active]
176299001061	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299001062	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
176299001063	trimer interface [polypeptide binding]; other site
176299001064	active site
176299001065	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
176299001066	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
176299001067	G1 box; other site
176299001068	putative GEF interaction site [polypeptide binding]; other site
176299001069	GTP/Mg2+ binding site [chemical binding]; other site
176299001070	Switch I region; other site
176299001071	G2 box; other site
176299001072	G3 box; other site
176299001073	Switch II region; other site
176299001074	G4 box; other site
176299001075	G5 box; other site
176299001076	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
176299001077	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
176299001078	Flavoprotein; Region: Flavoprotein; cl19190
176299001079	DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
176299001080	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
176299001081	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
176299001082	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
176299001083	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
176299001084	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
176299001085	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
176299001086	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299001087	S-adenosylmethionine binding site [chemical binding]; other site
176299001088	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
176299001089	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
176299001090	DNA binding site [nucleotide binding]
176299001091	catalytic residue [active]
176299001092	H2TH interface [polypeptide binding]; other site
176299001093	putative catalytic residues [active]
176299001094	turnover-facilitating residue; other site
176299001095	intercalation triad [nucleotide binding]; other site
176299001096	8OG recognition residue [nucleotide binding]; other site
176299001097	putative reading head residues; other site
176299001098	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
176299001099	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
176299001100	enoyl-CoA hydratase; Provisional; Region: PRK05862
176299001101	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
176299001102	substrate binding site [chemical binding]; other site
176299001103	oxyanion hole (OAH) forming residues; other site
176299001104	trimer interface [polypeptide binding]; other site
176299001105	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
176299001106	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
176299001107	DnaA N-terminal domain; Region: DnaA_N; pfam11638
176299001108	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299001109	Walker A motif; other site
176299001110	ATP binding site [chemical binding]; other site
176299001111	Walker B motif; other site
176299001112	arginine finger; other site
176299001113	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
176299001114	DnaA box-binding interface [nucleotide binding]; other site
176299001115	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
176299001116	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299001117	FeS/SAM binding site; other site
176299001118	HemN C-terminal domain; Region: HemN_C; pfam06969
176299001119	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
176299001120	active site
176299001121	dimerization interface [polypeptide binding]; other site
176299001122	ribonuclease PH; Reviewed; Region: rph; PRK00173
176299001123	Ribonuclease PH; Region: RNase_PH_bact; cd11362
176299001124	hexamer interface [polypeptide binding]; other site
176299001125	active site
176299001126	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
176299001127	HrcA protein C terminal domain; Region: HrcA; pfam01628
176299001128	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
176299001129	dimer interface [polypeptide binding]; other site
176299001130	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
176299001131	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
176299001132	active site
176299001133	phosphorylation site [posttranslational modification]
176299001134	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
176299001135	30S subunit binding site; other site
176299001136	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
176299001137	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
176299001138	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
176299001139	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
176299001140	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
176299001141	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
176299001142	Walker A/P-loop; other site
176299001143	ATP binding site [chemical binding]; other site
176299001144	Q-loop/lid; other site
176299001145	ABC transporter signature motif; other site
176299001146	Walker B; other site
176299001147	D-loop; other site
176299001148	H-loop/switch region; other site
176299001149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
176299001150	OstA-like protein; Region: OstA; pfam03968
176299001151	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
176299001152	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
176299001153	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
176299001154	tandem repeat interface [polypeptide binding]; other site
176299001155	oligomer interface [polypeptide binding]; other site
176299001156	active site residues [active]
176299001157	Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
176299001158	dimer interface [polypeptide binding]; other site
176299001159	DNA binding site [nucleotide binding]
176299001160	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
176299001161	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
176299001162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299001163	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
176299001164	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
176299001165	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
176299001166	lipoprotein signal peptidase; Provisional; Region: PRK14795
176299001167	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
176299001168	PAS domain; Region: PAS_8; pfam13188
176299001169	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299001170	dimer interface [polypeptide binding]; other site
176299001171	phosphorylation site [posttranslational modification]
176299001172	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299001173	ATP binding site [chemical binding]; other site
176299001174	Mg2+ binding site [ion binding]; other site
176299001175	G-X-G motif; other site
176299001176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299001177	active site
176299001178	phosphorylation site [posttranslational modification]
176299001179	intermolecular recognition site; other site
176299001180	dimerization interface [polypeptide binding]; other site
176299001181	Putative hemolysin [General function prediction only]; Region: COG3176
176299001182	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
176299001183	MutS domain I; Region: MutS_I; pfam01624
176299001184	MutS domain II; Region: MutS_II; pfam05188
176299001185	MutS domain III; Region: MutS_III; pfam05192
176299001186	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
176299001187	Walker A/P-loop; other site
176299001188	ATP binding site [chemical binding]; other site
176299001189	Q-loop/lid; other site
176299001190	ABC transporter signature motif; other site
176299001191	Walker B; other site
176299001192	D-loop; other site
176299001193	H-loop/switch region; other site
176299001194	PII uridylyl-transferase; Provisional; Region: PRK05092
176299001195	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
176299001196	metal binding triad; other site
176299001197	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
176299001198	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
176299001199	Zn2+ binding site [ion binding]; other site
176299001200	Mg2+ binding site [ion binding]; other site
176299001201	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
176299001202	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
176299001203	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
176299001204	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
176299001205	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
176299001206	tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
176299001207	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
176299001208	active site
176299001209	HIGH motif; other site
176299001210	dimer interface [polypeptide binding]; other site
176299001211	KMSKS motif; other site
176299001212	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
176299001213	Ligand Binding Site [chemical binding]; other site
176299001214	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
176299001215	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
176299001216	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
176299001217	Glycoprotease family; Region: Peptidase_M22; pfam00814
176299001218	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
176299001219	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299001220	Coenzyme A binding pocket [chemical binding]; other site
176299001221	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
176299001222	metal binding site 2 [ion binding]; metal-binding site
176299001223	putative DNA binding helix; other site
176299001224	metal binding site 1 [ion binding]; metal-binding site
176299001225	dimer interface [polypeptide binding]; other site
176299001226	structural Zn2+ binding site [ion binding]; other site
176299001227	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
176299001228	putative acyl-acceptor binding pocket; other site
176299001229	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
176299001230	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
176299001231	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299001232	FeS/SAM binding site; other site
176299001233	TRAM domain; Region: TRAM; pfam01938
176299001234	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
176299001235	PhoH-like protein; Region: PhoH; pfam02562
176299001236	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319
176299001237	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
176299001238	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
176299001239	Transporter associated domain; Region: CorC_HlyC; smart01091
176299001240	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
176299001241	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
176299001242	putative active site [active]
176299001243	catalytic triad [active]
176299001244	putative dimer interface [polypeptide binding]; other site
176299001245	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299001246	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299001247	non-specific DNA binding site [nucleotide binding]; other site
176299001248	salt bridge; other site
176299001249	sequence-specific DNA binding site [nucleotide binding]; other site
176299001250	S-adenosylmethionine synthetase; Validated; Region: PRK05250
176299001251	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
176299001252	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
176299001253	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
176299001254	Predicted S-adenosylmethionine-dependent methyltransferase [General function prediction only]; Region: COG0220
176299001255	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299001256	S-adenosylmethionine binding site [chemical binding]; other site
176299001257	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
176299001258	substrate binding site [chemical binding]; other site
176299001259	dimer interface [polypeptide binding]; other site
176299001260	ATP binding site [chemical binding]; other site
176299001261	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
176299001262	RmuC family; Region: RmuC; pfam02646
176299001263	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
176299001264	active site
176299001265	catalytic residues [active]
176299001266	metal binding site [ion binding]; metal-binding site
176299001267	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
176299001268	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
176299001269	putative active site [active]
176299001270	substrate binding site [chemical binding]; other site
176299001271	putative cosubstrate binding site; other site
176299001272	catalytic site [active]
176299001273	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
176299001274	substrate binding site [chemical binding]; other site
176299001275	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
176299001276	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
176299001277	dimerization interface 3.5A [polypeptide binding]; other site
176299001278	active site
176299001279	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
176299001280	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
176299001281	metal binding site [ion binding]; metal-binding site
176299001282	dimer interface [polypeptide binding]; other site
176299001283	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
176299001284	Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
176299001285	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
176299001286	trimer interface [polypeptide binding]; other site
176299001287	active site
176299001288	substrate binding site [chemical binding]; other site
176299001289	CoA binding site [chemical binding]; other site
176299001290	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
176299001291	Cache domain; Region: Cache_1; pfam02743
176299001292	HAMP domain; Region: HAMP; pfam00672
176299001293	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
176299001294	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
176299001295	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299001296	dimer interface [polypeptide binding]; other site
176299001297	putative CheW interface [polypeptide binding]; other site
176299001298	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
176299001299	active site
176299001300	tetramer interface [polypeptide binding]; other site
176299001301	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
176299001302	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
176299001303	putative dimer interface [polypeptide binding]; other site
176299001304	Uncharacterized small protein [Function unknown]; Region: COG5568
176299001305	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
176299001306	Ca2+ binding site [ion binding]; other site
176299001307	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
176299001308	Ca2+ binding site [ion binding]; other site
176299001309	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
176299001310	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299001311	motif II; other site
176299001312	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299001313	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
176299001314	homohexameric interface [polypeptide binding]; other site
176299001315	feedback inhibition sensing region; other site
176299001316	nucleotide binding site [chemical binding]; other site
176299001317	N-acetyl-L-glutamate binding site [chemical binding]; other site
176299001318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
176299001319	Predicted GTPase [General function prediction only]; Region: COG0218
176299001320	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
176299001321	G1 box; other site
176299001322	GTP/Mg2+ binding site [chemical binding]; other site
176299001323	Switch I region; other site
176299001324	G2 box; other site
176299001325	G3 box; other site
176299001326	Switch II region; other site
176299001327	G4 box; other site
176299001328	G5 box; other site
176299001329	membrane protein insertase; Provisional; Region: PRK01318
176299001330	YidC periplasmic domain; Region: YidC_periplas; pfam14849
176299001331	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
176299001332	ribonuclease P; Reviewed; Region: rnpA; PRK01313
176299001333	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
176299001334	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
176299001335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299001336	dimerization interface [polypeptide binding]; other site
176299001337	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299001338	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299001339	dimer interface [polypeptide binding]; other site
176299001340	putative CheW interface [polypeptide binding]; other site
176299001341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299001342	HAMP domain; Region: HAMP; pfam00672
176299001343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299001344	ATP binding site [chemical binding]; other site
176299001345	Mg2+ binding site [ion binding]; other site
176299001346	G-X-G motif; other site
176299001347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299001348	S-adenosylmethionine binding site [chemical binding]; other site
176299001349	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299001350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299001351	Walker A/P-loop; other site
176299001352	ATP binding site [chemical binding]; other site
176299001353	Q-loop/lid; other site
176299001354	ABC transporter signature motif; other site
176299001355	Walker B; other site
176299001356	D-loop; other site
176299001357	H-loop/switch region; other site
176299001358	TOBE domain; Region: TOBE_2; pfam08402
176299001359	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299001360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001361	dimer interface [polypeptide binding]; other site
176299001362	conserved gate region; other site
176299001363	putative PBP binding loops; other site
176299001364	ABC-ATPase subunit interface; other site
176299001365	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299001366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001367	dimer interface [polypeptide binding]; other site
176299001368	conserved gate region; other site
176299001369	putative PBP binding loops; other site
176299001370	ABC-ATPase subunit interface; other site
176299001371	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299001372	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
176299001373	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
176299001374	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
176299001375	active site
176299001376	metal binding site [ion binding]; metal-binding site
176299001377	hexamer interface [polypeptide binding]; other site
176299001378	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
176299001379	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
176299001380	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
176299001381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
176299001382	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
176299001383	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
176299001384	hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687
176299001385	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
176299001386	active site
176299001387	substrate binding pocket [chemical binding]; other site
176299001388	dimer interface [polypeptide binding]; other site
176299001389	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299001390	active site
176299001391	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
176299001392	putative substrate binding site [chemical binding]; other site
176299001393	putative ATP binding site [chemical binding]; other site
176299001394	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
176299001395	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
176299001396	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
176299001397	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
176299001398	active site
176299001399	dimer interface [polypeptide binding]; other site
176299001400	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
176299001401	dimer interface [polypeptide binding]; other site
176299001402	active site
176299001403	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
176299001404	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
176299001405	acyl-activating enzyme (AAE) consensus motif; other site
176299001406	putative AMP binding site [chemical binding]; other site
176299001407	putative active site [active]
176299001408	putative CoA binding site [chemical binding]; other site
176299001409	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299001410	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
176299001411	Walker A/P-loop; other site
176299001412	ATP binding site [chemical binding]; other site
176299001413	Q-loop/lid; other site
176299001414	ABC transporter signature motif; other site
176299001415	Walker B; other site
176299001416	D-loop; other site
176299001417	H-loop/switch region; other site
176299001418	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299001419	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
176299001420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001421	dimer interface [polypeptide binding]; other site
176299001422	conserved gate region; other site
176299001423	putative PBP binding loops; other site
176299001424	ABC-ATPase subunit interface; other site
176299001425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001426	dimer interface [polypeptide binding]; other site
176299001427	conserved gate region; other site
176299001428	putative PBP binding loops; other site
176299001429	ABC-ATPase subunit interface; other site
176299001430	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
176299001431	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
176299001432	N-terminal plug; other site
176299001433	ligand-binding site [chemical binding]; other site
176299001434	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299001435	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299001436	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299001437	PRC-barrel domain; Region: PRC; pfam05239
176299001438	Protein of unknown function (DUF982); Region: DUF982; pfam06169
176299001439	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
176299001440	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
176299001441	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
176299001442	FMN binding site [chemical binding]; other site
176299001443	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
176299001444	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
176299001445	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
176299001446	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299001447	dimer interface [polypeptide binding]; other site
176299001448	phosphorylation site [posttranslational modification]
176299001449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299001450	ATP binding site [chemical binding]; other site
176299001451	Mg2+ binding site [ion binding]; other site
176299001452	G-X-G motif; other site
176299001453	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
176299001454	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
176299001455	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
176299001456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001457	dimer interface [polypeptide binding]; other site
176299001458	conserved gate region; other site
176299001459	putative PBP binding loops; other site
176299001460	ABC-ATPase subunit interface; other site
176299001461	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
176299001462	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
176299001463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001464	dimer interface [polypeptide binding]; other site
176299001465	conserved gate region; other site
176299001466	putative PBP binding loops; other site
176299001467	ABC-ATPase subunit interface; other site
176299001468	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
176299001469	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
176299001470	Walker A/P-loop; other site
176299001471	ATP binding site [chemical binding]; other site
176299001472	Q-loop/lid; other site
176299001473	ABC transporter signature motif; other site
176299001474	Walker B; other site
176299001475	D-loop; other site
176299001476	H-loop/switch region; other site
176299001477	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
176299001478	PhoU domain; Region: PhoU; pfam01895
176299001479	PhoU domain; Region: PhoU; pfam01895
176299001480	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
176299001481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299001482	active site
176299001483	phosphorylation site [posttranslational modification]
176299001484	intermolecular recognition site; other site
176299001485	dimerization interface [polypeptide binding]; other site
176299001486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299001487	DNA binding site [nucleotide binding]
176299001488	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299001489	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299001490	inhibitor-cofactor binding pocket; inhibition site
176299001491	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299001492	catalytic residue [active]
176299001493	ornithine carbamoyltransferase; Provisional; Region: PRK00779
176299001494	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
176299001495	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
176299001496	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
176299001497	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
176299001498	dimerization interface [polypeptide binding]; other site
176299001499	domain crossover interface; other site
176299001500	redox-dependent activation switch; other site
176299001501	Uncharacterized protein affecting Mg2+/Co2+ transport [Inorganic ion transport and metabolism]; Region: ApaG; COG2967
176299001502	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
176299001503	homodimer interface [polypeptide binding]; other site
176299001504	substrate-cofactor binding pocket; other site
176299001505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299001506	catalytic residue [active]
176299001507	SAM riboswitch (alpha-proteobacteria); predicted by RFAM
176299001508	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
176299001509	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
176299001510	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
176299001511	trimer interface [polypeptide binding]; other site
176299001512	active site
176299001513	Deoxycytidine deaminase [Nucleotide transport and metabolism]; Region: Dcd; COG0717
176299001514	trimer interface [polypeptide binding]; other site
176299001515	active site
176299001516	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972
176299001517	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
176299001518	Uncharacterized conserved protein [Function unknown]; Region: COG5619
176299001519	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
176299001520	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
176299001521	active site
176299001522	catalytic residues [active]
176299001523	DNA binding site [nucleotide binding]
176299001524	Int/Topo IB signature motif; other site
176299001525	Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338
176299001526	tellurite resistance protein terB; Region: terB; cd07176
176299001527	putative metal binding site [ion binding]; other site
176299001528	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299001529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299001530	non-specific DNA binding site [nucleotide binding]; other site
176299001531	salt bridge; other site
176299001532	sequence-specific DNA binding site [nucleotide binding]; other site
176299001533	Predicted transcriptional regulator [Transcription]; Region: COG2932
176299001534	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
176299001535	Catalytic site [active]
176299001536	Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197
176299001537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299001538	S-adenosylmethionine binding site [chemical binding]; other site
176299001539	Helix-turn-helix domain; Region: HTH_36; pfam13730
176299001540	Transcription antiterminator [Transcription]; Region: NusG; COG0250
176299001541	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000
176299001542	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
176299001543	Phage capsid family; Region: Phage_capsid; cl19393
176299001544	Phage DNA packaging protein, Nu1 subunit of terminase [DNA replication, recombination, and repair]; Region: COG4220
176299001545	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
176299001546	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
176299001547	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
176299001548	Phage protein U [General function prediction only]; Region: COG3499
176299001549	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
176299001550	Phage protein D [General function prediction only]; Region: COG3500
176299001551	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
176299001552	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
176299001553	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299001554	non-specific DNA binding site [nucleotide binding]; other site
176299001555	salt bridge; other site
176299001556	sequence-specific DNA binding site [nucleotide binding]; other site
176299001557	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
176299001558	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
176299001559	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
176299001560	metal binding site [ion binding]; metal-binding site
176299001561	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
176299001562	Fasciclin domain; Region: Fasciclin; pfam02469
176299001563	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
176299001564	RNA polymerase sigma factor; Provisional; Region: PRK12537
176299001565	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299001566	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
176299001567	DNA binding residues [nucleotide binding]
176299001568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
176299001569	Anti-sigma-K factor rskA; Region: RskA; pfam10099
176299001570	aquaporin Z; Provisional; Region: PRK05420
176299001571	amphipathic channel; other site
176299001572	Asn-Pro-Ala signature motifs; other site
176299001573	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
176299001574	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
176299001575	DXD motif; other site
176299001576	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299001577	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299001578	substrate binding pocket [chemical binding]; other site
176299001579	membrane-bound complex binding site; other site
176299001580	hinge residues; other site
176299001581	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
176299001582	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
176299001583	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
176299001584	O-Antigen ligase; Region: Wzy_C; pfam04932
176299001585	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
176299001586	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
176299001587	putative active site [active]
176299001588	putative metal binding site [ion binding]; other site
176299001589	Predicted transcriptional regulator [Transcription]; Region: COG2932
176299001590	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
176299001591	Catalytic site [active]
176299001592	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299001593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299001594	active site
176299001595	phosphorylation site [posttranslational modification]
176299001596	intermolecular recognition site; other site
176299001597	dimerization interface [polypeptide binding]; other site
176299001598	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299001599	DNA binding residues [nucleotide binding]
176299001600	dimerization interface [polypeptide binding]; other site
176299001601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
176299001602	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
176299001603	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
176299001604	quinone interaction residues [chemical binding]; other site
176299001605	active site
176299001606	catalytic residues [active]
176299001607	FMN binding site [chemical binding]; other site
176299001608	substrate binding site [chemical binding]; other site
176299001609	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
176299001610	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
176299001611	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
176299001612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299001613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299001614	S-adenosylmethionine binding site [chemical binding]; other site
176299001615	Uncharacterized conserved protein [Function unknown]; Region: COG1284
176299001616	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
176299001617	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
176299001618	Uncharacterized conserved protein [Function unknown]; Region: COG1284
176299001619	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
176299001620	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
176299001621	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
176299001622	Uncharacterized conserved protein [Function unknown]; Region: COG2128
176299001623	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299001624	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299001625	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299001626	dimerization interface [polypeptide binding]; other site
176299001627	putative Zn2+ binding site [ion binding]; other site
176299001628	putative DNA binding site [nucleotide binding]; other site
176299001629	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299001630	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
176299001631	ATP binding site [chemical binding]; other site
176299001632	putative Mg++ binding site [ion binding]; other site
176299001633	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299001634	nucleotide binding region [chemical binding]; other site
176299001635	ATP-binding site [chemical binding]; other site
176299001636	DEAD/H associated; Region: DEAD_assoc; pfam08494
176299001637	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
176299001638	putative active site [active]
176299001639	putative metal binding site [ion binding]; other site
176299001640	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
176299001641	Ligand Binding Site [chemical binding]; other site
176299001642	conserved hypothetical protein; Region: alph_Pro_TM; TIGR02186
176299001643	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
176299001644	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
176299001645	Sel1-like repeats; Region: SEL1; smart00671
176299001646	Sel1-like repeats; Region: SEL1; smart00671
176299001647	Sel1-like repeats; Region: SEL1; smart00671
176299001648	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
176299001649	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299001650	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
176299001651	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
176299001652	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
176299001653	active site
176299001654	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
176299001655	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
176299001656	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
176299001657	dimer interface [polypeptide binding]; other site
176299001658	active site
176299001659	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
176299001660	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
176299001661	substrate binding site [chemical binding]; other site
176299001662	oxyanion hole (OAH) forming residues; other site
176299001663	trimer interface [polypeptide binding]; other site
176299001664	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
176299001665	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
176299001666	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
176299001667	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
176299001668	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
176299001669	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12671
176299001670	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
176299001671	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
176299001672	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
176299001673	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
176299001674	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
176299001675	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
176299001676	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
176299001677	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
176299001678	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
176299001679	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
176299001680	Protoglobin; Region: Protoglobin; pfam11563
176299001681	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299001682	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299001683	dimer interface [polypeptide binding]; other site
176299001684	putative CheW interface [polypeptide binding]; other site
176299001685	STAS domain; Region: STAS_2; pfam13466
176299001686	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299001687	active site
176299001688	phosphorylation site [posttranslational modification]
176299001689	intermolecular recognition site; other site
176299001690	dimerization interface [polypeptide binding]; other site
176299001691	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
176299001692	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
176299001693	putative binding surface; other site
176299001694	active site
176299001695	Ribosomal protein L12E/L44/L45/RPP1/RPP2 [Translation, ribosomal structure and biogenesis]; Region: RPP1A; COG2058
176299001696	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
176299001697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299001698	ATP binding site [chemical binding]; other site
176299001699	Mg2+ binding site [ion binding]; other site
176299001700	G-X-G motif; other site
176299001701	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
176299001702	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
176299001703	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
176299001704	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
176299001705	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
176299001706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299001707	active site
176299001708	phosphorylation site [posttranslational modification]
176299001709	intermolecular recognition site; other site
176299001710	dimerization interface [polypeptide binding]; other site
176299001711	CheB methylesterase; Region: CheB_methylest; pfam01339
176299001712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299001713	active site
176299001714	phosphorylation site [posttranslational modification]
176299001715	intermolecular recognition site; other site
176299001716	dimerization interface [polypeptide binding]; other site
176299001717	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13497
176299001718	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
176299001719	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
176299001720	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
176299001721	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299001722	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299001723	DNA binding residues [nucleotide binding]
176299001724	dimerization interface [polypeptide binding]; other site
176299001725	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299001726	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299001727	DNA binding residues [nucleotide binding]
176299001728	dimerization interface [polypeptide binding]; other site
176299001729	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299001730	dimerization interface [polypeptide binding]; other site
176299001731	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299001732	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299001733	dimer interface [polypeptide binding]; other site
176299001734	putative CheW interface [polypeptide binding]; other site
176299001735	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
176299001736	Na binding site [ion binding]; other site
176299001737	PAS fold; Region: PAS_7; pfam12860
176299001738	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299001739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299001740	dimer interface [polypeptide binding]; other site
176299001741	phosphorylation site [posttranslational modification]
176299001742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299001743	ATP binding site [chemical binding]; other site
176299001744	Mg2+ binding site [ion binding]; other site
176299001745	G-X-G motif; other site
176299001746	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299001747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299001748	active site
176299001749	phosphorylation site [posttranslational modification]
176299001750	intermolecular recognition site; other site
176299001751	dimerization interface [polypeptide binding]; other site
176299001752	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
176299001753	aspartate aminotransferase; Provisional; Region: PRK06108
176299001754	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299001755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299001756	homodimer interface [polypeptide binding]; other site
176299001757	catalytic residue [active]
176299001758	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
176299001759	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
176299001760	NAD binding site [chemical binding]; other site
176299001761	homodimer interface [polypeptide binding]; other site
176299001762	active site
176299001763	substrate binding site [chemical binding]; other site
176299001764	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
176299001765	active site
176299001766	dimer interface [polypeptide binding]; other site
176299001767	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
176299001768	rRNA binding site [nucleotide binding]; other site
176299001769	predicted 30S ribosome binding site; other site
176299001770	Low molecular weight phosphatase family; Region: LMWPc; cd00115
176299001771	active site
176299001772	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5328
176299001773	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
176299001774	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
176299001775	NAD binding site [chemical binding]; other site
176299001776	dimerization interface [polypeptide binding]; other site
176299001777	product binding site; other site
176299001778	substrate binding site [chemical binding]; other site
176299001779	zinc binding site [ion binding]; other site
176299001780	catalytic residues [active]
176299001781	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
176299001782	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
176299001783	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
176299001784	hinge; other site
176299001785	active site
176299001786	flagellin; Reviewed; Region: PRK12687
176299001787	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
176299001788	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
176299001789	flagellin; Reviewed; Region: PRK12687
176299001790	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
176299001791	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
176299001792	flagellin; Reviewed; Region: PRK12687
176299001793	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
176299001794	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
176299001795	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
176299001796	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
176299001797	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
176299001798	Uncharacterized conserved protein [Function unknown]; Region: COG3334
176299001799	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
176299001800	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
176299001801	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
176299001802	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
176299001803	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
176299001804	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
176299001805	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
176299001806	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK12782
176299001807	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
176299001808	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06003
176299001809	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
176299001810	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06002
176299001811	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
176299001812	Walker A motif; other site
176299001813	ATP binding site [chemical binding]; other site
176299001814	Walker B motif; other site
176299001815	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12642
176299001816	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
176299001817	flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173
176299001818	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
176299001819	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299001820	flagellar motor protein MotA; Validated; Region: PRK09110
176299001821	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
176299001822	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
176299001823	flagellar motor switch protein FliN; Region: fliN; TIGR02480
176299001824	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
176299001825	FliG N-terminal domain; Region: FliG_N; pfam14842
176299001826	FliG middle domain; Region: FliG_M; pfam14841
176299001827	FliG C-terminal domain; Region: FliG_C; pfam01706
176299001828	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
176299001829	flagellin; Reviewed; Region: PRK12687
176299001830	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
176299001831	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
176299001832	flagellar motor protein MotB; Validated; Region: motB; PRK05996
176299001833	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
176299001834	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
176299001835	ligand binding site [chemical binding]; other site
176299001836	chemotaxis protein; Reviewed; Region: PRK12798
176299001837	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
176299001838	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
176299001839	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299001840	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299001841	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299001842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
176299001843	active site
176299001844	dimerization interface [polypeptide binding]; other site
176299001845	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
176299001846	DNA binding site [nucleotide binding]
176299001847	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
176299001848	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
176299001849	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
176299001850	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
176299001851	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
176299001852	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
176299001853	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
176299001854	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
176299001855	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
176299001856	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12793
176299001857	Flagellar biosynthesis regulator FlbT [Cell motility and secretion]; Region: FlbT; COG5443
176299001858	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
176299001859	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
176299001860	PRC-barrel domain; Region: PRC; pfam05239
176299001861	flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010
176299001862	FHIPEP family; Region: FHIPEP; cl07980
176299001863	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
176299001864	Rod binding protein; Region: Rod-binding; pfam10135
176299001865	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
176299001866	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
176299001867	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
176299001868	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
176299001869	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
176299001870	homodimer interface [polypeptide binding]; other site
176299001871	NADP binding site [chemical binding]; other site
176299001872	substrate binding site [chemical binding]; other site
176299001873	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299001874	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299001875	DNA binding site [nucleotide binding]
176299001876	domain linker motif; other site
176299001877	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
176299001878	ligand binding site [chemical binding]; other site
176299001879	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299001880	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299001881	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299001882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
176299001883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001884	putative PBP binding loops; other site
176299001885	dimer interface [polypeptide binding]; other site
176299001886	ABC-ATPase subunit interface; other site
176299001887	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
176299001888	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299001889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001890	dimer interface [polypeptide binding]; other site
176299001891	conserved gate region; other site
176299001892	putative PBP binding loops; other site
176299001893	ABC-ATPase subunit interface; other site
176299001894	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
176299001895	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
176299001896	active site
176299001897	catalytic site [active]
176299001898	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
176299001899	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299001900	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299001901	Walker A/P-loop; other site
176299001902	ATP binding site [chemical binding]; other site
176299001903	Q-loop/lid; other site
176299001904	ABC transporter signature motif; other site
176299001905	Walker B; other site
176299001906	D-loop; other site
176299001907	H-loop/switch region; other site
176299001908	TOBE domain; Region: TOBE_2; pfam08402
176299001909	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
176299001910	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
176299001911	active site
176299001912	metal binding site [ion binding]; metal-binding site
176299001913	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
176299001914	phosphogluconate dehydratase; Validated; Region: PRK09054
176299001915	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
176299001916	putative active site [active]
176299001917	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
176299001918	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
176299001919	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
176299001920	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299001921	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299001922	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
176299001923	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
176299001924	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
176299001925	Predicted flavoproteins [General function prediction only]; Region: COG2081
176299001926	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299001927	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299001928	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299001929	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299001930	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299001931	dimerization interface [polypeptide binding]; other site
176299001932	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
176299001933	tetramer interface [polypeptide binding]; other site
176299001934	active site
176299001935	Mg2+/Mn2+ binding site [ion binding]; other site
176299001936	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299001937	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299001938	non-specific DNA binding site [nucleotide binding]; other site
176299001939	salt bridge; other site
176299001940	sequence-specific DNA binding site [nucleotide binding]; other site
176299001941	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
176299001942	Domain of unknown function (DUF955); Region: DUF955; pfam06114
176299001943	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
176299001944	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299001945	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
176299001946	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299001947	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
176299001948	Walker A/P-loop; other site
176299001949	ATP binding site [chemical binding]; other site
176299001950	Q-loop/lid; other site
176299001951	ABC transporter signature motif; other site
176299001952	Walker B; other site
176299001953	D-loop; other site
176299001954	H-loop/switch region; other site
176299001955	TOBE domain; Region: TOBE_2; pfam08402
176299001956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001957	dimer interface [polypeptide binding]; other site
176299001958	conserved gate region; other site
176299001959	putative PBP binding loops; other site
176299001960	ABC-ATPase subunit interface; other site
176299001961	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299001962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001963	dimer interface [polypeptide binding]; other site
176299001964	conserved gate region; other site
176299001965	putative PBP binding loops; other site
176299001966	ABC-ATPase subunit interface; other site
176299001967	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
176299001968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001969	dimer interface [polypeptide binding]; other site
176299001970	conserved gate region; other site
176299001971	putative PBP binding loops; other site
176299001972	ABC-ATPase subunit interface; other site
176299001973	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
176299001974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299001975	dimer interface [polypeptide binding]; other site
176299001976	conserved gate region; other site
176299001977	putative PBP binding loops; other site
176299001978	ABC-ATPase subunit interface; other site
176299001979	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
176299001980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299001981	putative active site [active]
176299001982	heme pocket [chemical binding]; other site
176299001983	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299001984	dimer interface [polypeptide binding]; other site
176299001985	phosphorylation site [posttranslational modification]
176299001986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299001987	ATP binding site [chemical binding]; other site
176299001988	Mg2+ binding site [ion binding]; other site
176299001989	G-X-G motif; other site
176299001990	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
176299001991	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
176299001992	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
176299001993	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299001994	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299001995	putative substrate translocation pore; other site
176299001996	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
176299001997	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
176299001998	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
176299001999	active site
176299002000	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
176299002001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331
176299002002	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
176299002003	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
176299002004	NAD binding site [chemical binding]; other site
176299002005	substrate binding site [chemical binding]; other site
176299002006	catalytic Zn binding site [ion binding]; other site
176299002007	tetramer interface [polypeptide binding]; other site
176299002008	structural Zn binding site [ion binding]; other site
176299002009	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
176299002010	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
176299002011	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299002012	dimerization interface [polypeptide binding]; other site
176299002013	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299002014	ATP binding site [chemical binding]; other site
176299002015	Mg2+ binding site [ion binding]; other site
176299002016	G-X-G motif; other site
176299002017	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299002018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299002019	active site
176299002020	phosphorylation site [posttranslational modification]
176299002021	intermolecular recognition site; other site
176299002022	dimerization interface [polypeptide binding]; other site
176299002023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299002024	DNA binding site [nucleotide binding]
176299002025	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
176299002026	MPT binding site; other site
176299002027	trimer interface [polypeptide binding]; other site
176299002028	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
176299002029	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
176299002030	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
176299002031	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
176299002032	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299002033	binding surface
176299002034	TPR motif; other site
176299002035	TPR repeat; Region: TPR_11; pfam13414
176299002036	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299002037	binding surface
176299002038	TPR repeat; Region: TPR_11; pfam13414
176299002039	TPR motif; other site
176299002040	TPR repeat; Region: TPR_11; pfam13414
176299002041	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
176299002042	substrate binding pocket [chemical binding]; other site
176299002043	chain length determination region; other site
176299002044	substrate-Mg2+ binding site; other site
176299002045	catalytic residues [active]
176299002046	aspartate-rich region 1; other site
176299002047	active site lid residues [active]
176299002048	aspartate-rich region 2; other site
176299002049	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
176299002050	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
176299002051	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
176299002052	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
176299002053	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
176299002054	oligomer interface [polypeptide binding]; other site
176299002055	tandem repeat interface [polypeptide binding]; other site
176299002056	active site residues [active]
176299002057	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
176299002058	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
176299002059	dimer interface [polypeptide binding]; other site
176299002060	motif 1; other site
176299002061	active site
176299002062	motif 2; other site
176299002063	motif 3; other site
176299002064	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
176299002065	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
176299002066	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
176299002067	hinge; other site
176299002068	active site
176299002069	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
176299002070	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
176299002071	Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092
176299002072	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
176299002073	Uncharacterized conserved protein [Function unknown]; Region: COG1683
176299002074	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
176299002075	HAMP domain; Region: HAMP; pfam00672
176299002076	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299002077	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299002078	dimer interface [polypeptide binding]; other site
176299002079	putative CheW interface [polypeptide binding]; other site
176299002080	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
176299002081	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
176299002082	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
176299002083	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
176299002084	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
176299002085	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
176299002086	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
176299002087	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
176299002088	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
176299002089	RNA binding site [nucleotide binding]; other site
176299002090	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
176299002091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299002092	S-adenosylmethionine binding site [chemical binding]; other site
176299002093	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
176299002094	4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959
176299002095	putative active site [active]
176299002096	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299002097	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299002098	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299002099	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299002100	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
176299002101	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299002102	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299002103	dimerization interface [polypeptide binding]; other site
176299002104	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
176299002105	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
176299002106	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
176299002107	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
176299002108	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
176299002109	nudix motif; other site
176299002110	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
176299002111	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
176299002112	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
176299002113	putative ADP-binding pocket [chemical binding]; other site
176299002114	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299002115	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299002116	DNA-binding site [nucleotide binding]; DNA binding site
176299002117	FCD domain; Region: FCD; pfam07729
176299002118	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4949
176299002119	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299002120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299002121	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299002122	putative effector binding pocket; other site
176299002123	dimerization interface [polypeptide binding]; other site
176299002124	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
176299002125	FAD binding domain; Region: FAD_binding_4; pfam01565
176299002126	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
176299002127	FAD binding domain; Region: FAD_binding_4; cl19922
176299002128	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
176299002129	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
176299002130	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
176299002131	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
176299002132	Cysteine-rich domain; Region: CCG; pfam02754
176299002133	Cysteine-rich domain; Region: CCG; pfam02754
176299002134	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
176299002135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299002136	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299002137	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
176299002138	Predicted membrane protein [Function unknown]; Region: COG2855
176299002139	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299002140	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299002141	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299002142	dimerization interface [polypeptide binding]; other site
176299002143	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
176299002144	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
176299002145	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
176299002146	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
176299002147	dimer interface [polypeptide binding]; other site
176299002148	motif 1; other site
176299002149	active site
176299002150	motif 2; other site
176299002151	motif 3; other site
176299002152	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
176299002153	anticodon binding site; other site
176299002154	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
176299002155	dimer interface [polypeptide binding]; other site
176299002156	putative metal binding site [ion binding]; other site
176299002157	ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705
176299002158	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
176299002159	dimer interface [polypeptide binding]; other site
176299002160	motif 1; other site
176299002161	active site
176299002162	motif 2; other site
176299002163	motif 3; other site
176299002164	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
176299002165	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
176299002166	Predicted membrane protein [Function unknown]; Region: COG2259
176299002167	chaperonin GroEL; Reviewed; Region: groEL; PRK12850
176299002168	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
176299002169	ring oligomerisation interface [polypeptide binding]; other site
176299002170	ATP/Mg binding site [chemical binding]; other site
176299002171	stacking interactions; other site
176299002172	hinge regions; other site
176299002173	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
176299002174	oligomerisation interface [polypeptide binding]; other site
176299002175	mobile loop; other site
176299002176	roof hairpin; other site
176299002177	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
176299002178	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299002179	active site
176299002180	motif I; other site
176299002181	motif II; other site
176299002182	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
176299002183	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
176299002184	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
176299002185	active site
176299002186	Riboflavin kinase; Region: Flavokinase; smart00904
176299002187	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
176299002188	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
176299002189	active site
176299002190	HIGH motif; other site
176299002191	nucleotide binding site [chemical binding]; other site
176299002192	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
176299002193	active site
176299002194	KMSKS motif; other site
176299002195	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
176299002196	tRNA binding surface [nucleotide binding]; other site
176299002197	anticodon binding site; other site
176299002198	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
176299002199	nucleoside/Zn binding site; other site
176299002200	dimer interface [polypeptide binding]; other site
176299002201	catalytic motif [active]
176299002202	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
176299002203	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
176299002204	RNA binding surface [nucleotide binding]; other site
176299002205	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
176299002206	active site
176299002207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299002208	S-adenosylmethionine binding site [chemical binding]; other site
176299002209	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
176299002210	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
176299002211	active site
176299002212	nucleophile elbow; other site
176299002213	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
176299002214	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
176299002215	TrkA-N domain; Region: TrkA_N; pfam02254
176299002216	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
176299002217	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
176299002218	active site
176299002219	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
176299002220	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
176299002221	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
176299002222	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
176299002223	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
176299002224	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299002225	motif II; other site
176299002226	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
176299002227	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
176299002228	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
176299002229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299002230	ATP binding site [chemical binding]; other site
176299002231	Mg2+ binding site [ion binding]; other site
176299002232	G-X-G motif; other site
176299002233	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
176299002234	ATP binding site [chemical binding]; other site
176299002235	MutL C terminal dimerization domain; Region: MutL_C; pfam08676
176299002236	PAS fold; Region: PAS_7; pfam12860
176299002237	PAS domain; Region: PAS; smart00091
176299002238	PAS fold; Region: PAS_4; pfam08448
176299002239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299002240	active site
176299002241	phosphorylation site [posttranslational modification]
176299002242	intermolecular recognition site; other site
176299002243	dimerization interface [polypeptide binding]; other site
176299002244	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299002245	metal binding site [ion binding]; metal-binding site
176299002246	active site
176299002247	I-site; other site
176299002248	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299002249	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
176299002250	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
176299002251	active site
176299002252	intersubunit interface [polypeptide binding]; other site
176299002253	catalytic residue [active]
176299002254	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
176299002255	short chain dehydrogenase; Provisional; Region: PRK12939
176299002256	classical (c) SDRs; Region: SDR_c; cd05233
176299002257	NAD(P) binding site [chemical binding]; other site
176299002258	active site
176299002259	Transcriptional regulator [Transcription]; Region: IclR; COG1414
176299002260	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
176299002261	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299002262	putative DNA binding site [nucleotide binding]; other site
176299002263	putative Zn2+ binding site [ion binding]; other site
176299002264	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299002265	Autoinducer binding domain; Region: Autoind_bind; pfam03472
176299002266	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299002267	DNA binding residues [nucleotide binding]
176299002268	dimerization interface [polypeptide binding]; other site
176299002269	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299002270	NMT1-like family; Region: NMT1_2; pfam13379
176299002271	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
176299002272	Domain of unknown function DUF59; Region: DUF59; pfam01883
176299002273	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
176299002274	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
176299002275	Walker A motif; other site
176299002276	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
176299002277	uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837
176299002278	Cl binding site [ion binding]; other site
176299002279	oligomer interface [polypeptide binding]; other site
176299002280	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
176299002281	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
176299002282	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
176299002283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
176299002284	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
176299002285	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
176299002286	F0F1 ATP synthase subunit B'; Validated; Region: PRK09174
176299002287	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
176299002288	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
176299002289	F0F1 ATP synthase subunit B; Validated; Region: PRK09173
176299002290	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
176299002291	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
176299002292	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
176299002293	trimer interface [polypeptide binding]; other site
176299002294	active site
176299002295	substrate binding site [chemical binding]; other site
176299002296	CoA binding site [chemical binding]; other site
176299002297	Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
176299002298	RNA/DNA hybrid binding site [nucleotide binding]; other site
176299002299	active site
176299002300	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
176299002301	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299002302	FeS/SAM binding site; other site
176299002303	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
176299002304	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
176299002305	FAD binding domain; Region: FAD_binding_4; pfam01565
176299002306	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
176299002307	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
176299002308	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
176299002309	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
176299002310	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
176299002311	[2Fe-2S] cluster binding site [ion binding]; other site
176299002312	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
176299002313	putative alpha subunit interface [polypeptide binding]; other site
176299002314	putative active site [active]
176299002315	putative substrate binding site [chemical binding]; other site
176299002316	Fe binding site [ion binding]; other site
176299002317	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
176299002318	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
176299002319	FAD binding pocket [chemical binding]; other site
176299002320	FAD binding motif [chemical binding]; other site
176299002321	phosphate binding motif [ion binding]; other site
176299002322	beta-alpha-beta structure motif; other site
176299002323	NAD binding pocket [chemical binding]; other site
176299002324	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299002325	catalytic loop [active]
176299002326	iron binding site [ion binding]; other site
176299002327	BA14K-like protein; Region: BA14K; pfam07886
176299002328	BA14K-like protein; Region: BA14K; pfam07886
176299002329	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
176299002330	Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834
176299002331	Cl binding site [ion binding]; other site
176299002332	oligomer interface [polypeptide binding]; other site
176299002333	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299002334	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
176299002335	active site
176299002336	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
176299002337	enoyl-CoA hydratase; Provisional; Region: PRK06023
176299002338	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
176299002339	substrate binding site [chemical binding]; other site
176299002340	oxyanion hole (OAH) forming residues; other site
176299002341	trimer interface [polypeptide binding]; other site
176299002342	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
176299002343	TRAM domain; Region: TRAM; cl01282
176299002344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299002345	S-adenosylmethionine binding site [chemical binding]; other site
176299002346	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
176299002347	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
176299002348	RNA binding surface [nucleotide binding]; other site
176299002349	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
176299002350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299002351	S-adenosylmethionine binding site [chemical binding]; other site
176299002352	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
176299002353	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299002354	dimerization interface [polypeptide binding]; other site
176299002355	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299002356	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299002357	dimer interface [polypeptide binding]; other site
176299002358	putative CheW interface [polypeptide binding]; other site
176299002359	Nucleoside recognition; Region: Gate; pfam07670
176299002360	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299002361	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299002362	putative DNA binding site [nucleotide binding]; other site
176299002363	putative Zn2+ binding site [ion binding]; other site
176299002364	Uncharacterized conserved protein [Function unknown]; Region: COG3603
176299002365	ACT domain; Region: ACT_7; pfam13840
176299002366	Uncharacterized conserved protein [Function unknown]; Region: COG4538
176299002367	Uncharacterized conserved protein [Function unknown]; Region: COG1359
176299002368	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299002369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299002370	non-specific DNA binding site [nucleotide binding]; other site
176299002371	salt bridge; other site
176299002372	sequence-specific DNA binding site [nucleotide binding]; other site
176299002373	SnoaL-like domain; Region: SnoaL_2; pfam12680
176299002374	Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154
176299002375	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
176299002376	TPP-binding site; other site
176299002377	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
176299002378	PYR/PP interface [polypeptide binding]; other site
176299002379	dimer interface [polypeptide binding]; other site
176299002380	TPP binding site [chemical binding]; other site
176299002381	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
176299002382	Pirin-related protein [General function prediction only]; Region: COG1741
176299002383	Pirin; Region: Pirin; pfam02678
176299002384	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
176299002385	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
176299002386	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
176299002387	putative active site [active]
176299002388	Zn binding site [ion binding]; other site
176299002389	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
176299002390	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
176299002391	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
176299002392	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
176299002393	Walker A/P-loop; other site
176299002394	ATP binding site [chemical binding]; other site
176299002395	Q-loop/lid; other site
176299002396	ABC transporter signature motif; other site
176299002397	Walker B; other site
176299002398	D-loop; other site
176299002399	H-loop/switch region; other site
176299002400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
176299002401	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
176299002402	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09314
176299002403	GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807
176299002404	dimerization interface [polypeptide binding]; other site
176299002405	active site
176299002406	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
176299002407	Tetramer interface [polypeptide binding]; other site
176299002408	active site
176299002409	FMN-binding site [chemical binding]; other site
176299002410	Protein of unknown function (DUF1344); Region: DUF1344; pfam07076
176299002411	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
176299002412	catalytic core [active]
176299002413	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
176299002414	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
176299002415	NAD binding site [chemical binding]; other site
176299002416	homotetramer interface [polypeptide binding]; other site
176299002417	homodimer interface [polypeptide binding]; other site
176299002418	substrate binding site [chemical binding]; other site
176299002419	active site
176299002420	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
176299002421	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
176299002422	HSP70 interaction site [polypeptide binding]; other site
176299002423	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
176299002424	dimer interface [polypeptide binding]; other site
176299002425	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
176299002426	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
176299002427	Pyridoxine 5'-phosphate oxidase C-terminal dimerization region; Region: PNPOx_C; pfam10590
176299002428	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
176299002429	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538
176299002430	metal binding site [ion binding]; metal-binding site
176299002431	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
176299002432	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
176299002433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299002434	motif II; other site
176299002435	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
176299002436	dimer interface [polypeptide binding]; other site
176299002437	ligand binding site [chemical binding]; other site
176299002438	Putative modulator of DNA gyrase; Region: PmbA_TldD; cl19356
176299002439	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
176299002440	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
176299002441	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
176299002442	C-terminal domain of Cytochrome c Oxidase subunit II; Region: CcO_II_C; cd13912
176299002443	subunit II/VIb interface [polypeptide binding]; other site
176299002444	subunit II/VIc interface [polypeptide binding]; other site
176299002445	CuA binding site [ion binding]; other site
176299002446	subunit I/II interface [polypeptide binding]; other site
176299002447	subunit II/IV interface [polypeptide binding]; other site
176299002448	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
176299002449	Subunit I/III interface [polypeptide binding]; other site
176299002450	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
176299002451	D-pathway; other site
176299002452	Subunit I/VIIc interface [polypeptide binding]; other site
176299002453	Subunit I/IV interface [polypeptide binding]; other site
176299002454	Subunit I/II interface [polypeptide binding]; other site
176299002455	Low-spin heme (heme a) binding site [chemical binding]; other site
176299002456	Subunit I/VIIa interface [polypeptide binding]; other site
176299002457	Subunit I/VIa interface [polypeptide binding]; other site
176299002458	Dimer interface; other site
176299002459	Putative water exit pathway; other site
176299002460	Binuclear center (heme a3/CuB) [ion binding]; other site
176299002461	K-pathway; other site
176299002462	Subunit I/Vb interface [polypeptide binding]; other site
176299002463	Putative proton exit pathway; other site
176299002464	Subunit I/VIb interface; other site
176299002465	Subunit I/VIc interface [polypeptide binding]; other site
176299002466	Electron transfer pathway; other site
176299002467	Subunit I/VIIIb interface [polypeptide binding]; other site
176299002468	Subunit I/VIIb interface [polypeptide binding]; other site
176299002469	Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957
176299002470	putative active site [active]
176299002471	Cytochrome oxidase assembly factor [Posttranslational modification, protein turnover, chaperones]; Region: COX11; COG3175
176299002472	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
176299002473	Subunit III/VIIa interface [polypeptide binding]; other site
176299002474	Phospholipid binding site [chemical binding]; other site
176299002475	Subunit I/III interface [polypeptide binding]; other site
176299002476	Subunit III/VIb interface [polypeptide binding]; other site
176299002477	Subunit III/VIa interface; other site
176299002478	Subunit III/Vb interface [polypeptide binding]; other site
176299002479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
176299002480	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
176299002481	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
176299002482	Fe-S cluster binding site [ion binding]; other site
176299002483	substrate binding site [chemical binding]; other site
176299002484	catalytic site [active]
176299002485	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
176299002486	Phosphotransferase enzyme family; Region: APH; pfam01636
176299002487	putative active site [active]
176299002488	putative substrate binding site [chemical binding]; other site
176299002489	ATP binding site [chemical binding]; other site
176299002490	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
176299002491	RNA/DNA hybrid binding site [nucleotide binding]; other site
176299002492	active site
176299002493	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
176299002494	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
176299002495	Autotransporter beta-domain; Region: Autotransporter; pfam03797
176299002496	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
176299002497	catalytic triad [active]
176299002498	dimer interface [polypeptide binding]; other site
176299002499	Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233
176299002500	Putative transcriptional regulator [Transcription]; Region: COG1678
176299002501	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
176299002502	Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005
176299002503	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
176299002504	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
176299002505	PAS fold; Region: PAS_3; pfam08447
176299002506	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299002507	putative active site [active]
176299002508	heme pocket [chemical binding]; other site
176299002509	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299002510	metal binding site [ion binding]; metal-binding site
176299002511	active site
176299002512	I-site; other site
176299002513	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299002514	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
176299002515	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299002516	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
176299002517	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
176299002518	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
176299002519	threonine synthase; Validated; Region: PRK09225
176299002520	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
176299002521	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299002522	catalytic residue [active]
176299002523	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
176299002524	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299002525	active site
176299002526	motif I; other site
176299002527	motif II; other site
176299002528	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299002529	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299002530	DNA-binding site [nucleotide binding]; DNA binding site
176299002531	FCD domain; Region: FCD; pfam07729
176299002532	Uncharacterized conserved protein [Function unknown]; Region: COG3543
176299002533	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
176299002534	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
176299002535	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299002536	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
176299002537	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
176299002538	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
176299002539	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
176299002540	minor groove reading motif; other site
176299002541	helix-hairpin-helix signature motif; other site
176299002542	substrate binding pocket [chemical binding]; other site
176299002543	active site
176299002544	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
176299002545	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
176299002546	DNA binding and oxoG recognition site [nucleotide binding]
176299002547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5389
176299002548	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
176299002549	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
176299002550	catalytic residues [active]
176299002551	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
176299002552	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
176299002553	Walker A/P-loop; other site
176299002554	ATP binding site [chemical binding]; other site
176299002555	Q-loop/lid; other site
176299002556	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
176299002557	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
176299002558	ABC transporter signature motif; other site
176299002559	Walker B; other site
176299002560	D-loop; other site
176299002561	H-loop/switch region; other site
176299002562	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
176299002563	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
176299002564	putative metal binding site [ion binding]; other site
176299002565	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
176299002566	active site
176299002567	pyruvate phosphate dikinase; Provisional; Region: PRK09279
176299002568	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
176299002569	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
176299002570	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
176299002571	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
176299002572	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
176299002573	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
176299002574	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
176299002575	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
176299002576	malate:quinone oxidoreductase; Validated; Region: PRK05257
176299002577	Predicted dehydrogenase [General function prediction only]; Region: COG0579
176299002578	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
176299002579	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
176299002580	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
176299002581	CysD dimerization site [polypeptide binding]; other site
176299002582	G1 box; other site
176299002583	putative GEF interaction site [polypeptide binding]; other site
176299002584	GTP/Mg2+ binding site [chemical binding]; other site
176299002585	Switch I region; other site
176299002586	G2 box; other site
176299002587	G3 box; other site
176299002588	Switch II region; other site
176299002589	G4 box; other site
176299002590	G5 box; other site
176299002591	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
176299002592	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
176299002593	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
176299002594	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
176299002595	Active Sites [active]
176299002596	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
176299002597	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
176299002598	Active Sites [active]
176299002599	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299002600	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299002601	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
176299002602	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299002603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299002604	dimer interface [polypeptide binding]; other site
176299002605	conserved gate region; other site
176299002606	putative PBP binding loops; other site
176299002607	ABC-ATPase subunit interface; other site
176299002608	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299002609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299002610	dimer interface [polypeptide binding]; other site
176299002611	conserved gate region; other site
176299002612	putative PBP binding loops; other site
176299002613	ABC-ATPase subunit interface; other site
176299002614	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
176299002615	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
176299002616	Walker A/P-loop; other site
176299002617	ATP binding site [chemical binding]; other site
176299002618	Q-loop/lid; other site
176299002619	ABC transporter signature motif; other site
176299002620	Walker B; other site
176299002621	D-loop; other site
176299002622	H-loop/switch region; other site
176299002623	TOBE-like domain; Region: TOBE_3; pfam12857
176299002624	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
176299002625	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
176299002626	NAD(P) binding site [chemical binding]; other site
176299002627	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299002628	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
176299002629	FOG: CBS domain [General function prediction only]; Region: COG0517
176299002630	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
176299002631	metal binding site [ion binding]; metal-binding site
176299002632	nucleotidyl binding site; other site
176299002633	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
176299002634	transcriptional regulator BetI; Validated; Region: PRK00767
176299002635	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299002636	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
176299002637	NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090
176299002638	tetrameric interface [polypeptide binding]; other site
176299002639	NAD binding site [chemical binding]; other site
176299002640	catalytic residues [active]
176299002641	choline dehydrogenase; Validated; Region: PRK02106
176299002642	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
176299002643	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
176299002644	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
176299002645	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
176299002646	putative ion selectivity filter; other site
176299002647	putative pore gating glutamate residue; other site
176299002648	putative H+/Cl- coupling transport residue; other site
176299002649	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
176299002650	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
176299002651	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299002652	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
176299002653	C-terminal domain interface [polypeptide binding]; other site
176299002654	GSH binding site (G-site) [chemical binding]; other site
176299002655	dimer interface [polypeptide binding]; other site
176299002656	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
176299002657	dimer interface [polypeptide binding]; other site
176299002658	N-terminal domain interface [polypeptide binding]; other site
176299002659	substrate binding pocket (H-site) [chemical binding]; other site
176299002660	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299002661	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
176299002662	putative C-terminal domain interface [polypeptide binding]; other site
176299002663	putative GSH binding site (G-site) [chemical binding]; other site
176299002664	putative dimer interface [polypeptide binding]; other site
176299002665	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
176299002666	dimer interface [polypeptide binding]; other site
176299002667	N-terminal domain interface [polypeptide binding]; other site
176299002668	putative substrate binding pocket (H-site) [chemical binding]; other site
176299002669	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299002670	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299002671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299002672	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299002673	putative substrate translocation pore; other site
176299002674	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
176299002675	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
176299002676	ATP-dependent DNA ligase; Validated; Region: PRK09247
176299002677	DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675
176299002678	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
176299002679	active site
176299002680	DNA binding site [nucleotide binding]
176299002681	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
176299002682	DNA binding site [nucleotide binding]
176299002683	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
176299002684	Sulfur oxidation protein SoxY; Region: SoxY; cl19207
176299002685	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299002686	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
176299002687	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952
176299002688	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
176299002689	metal-binding site [ion binding]
176299002690	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
176299002691	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
176299002692	metal-binding site [ion binding]
176299002693	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
176299002694	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
176299002695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299002696	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299002697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299002698	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299002699	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299002700	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299002701	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299002702	putative DNA binding site [nucleotide binding]; other site
176299002703	putative Zn2+ binding site [ion binding]; other site
176299002704	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
176299002705	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
176299002706	RES domain; Region: RES; smart00953
176299002707	Q-loop/lid; other site
176299002708	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299002709	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299002710	ABC transporter signature motif; other site
176299002711	Walker B; other site
176299002712	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
176299002713	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299002714	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
176299002715	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
176299002716	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299002717	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312
176299002718	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
176299002719	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
176299002720	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
176299002721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299002722	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
176299002723	putative effector binding pocket; other site
176299002724	putative dimerization interface [polypeptide binding]; other site
176299002725	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
176299002726	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299002727	NAD(P) binding site [chemical binding]; other site
176299002728	active site
176299002729	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
176299002730	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
176299002731	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
176299002732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299002733	Walker A motif; other site
176299002734	ATP binding site [chemical binding]; other site
176299002735	Walker B motif; other site
176299002736	Predicted transcriptional regulators [Transcription]; Region: COG1733
176299002737	putative DNA binding site [nucleotide binding]; other site
176299002738	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299002739	putative Zn2+ binding site [ion binding]; other site
176299002740	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
176299002741	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
176299002742	putative NAD(P) binding site [chemical binding]; other site
176299002743	active site
176299002744	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
176299002745	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299002746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299002747	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299002748	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299002749	active site
176299002750	catalytic tetrad [active]
176299002751	Predicted transcriptional regulator [Transcription]; Region: COG2378
176299002752	HTH domain; Region: HTH_11; pfam08279
176299002753	WYL domain; Region: WYL; pfam13280
176299002754	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
176299002755	putative dimer interface [polypeptide binding]; other site
176299002756	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
176299002757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299002758	S-adenosylmethionine binding site [chemical binding]; other site
176299002759	aminotransferase; Provisional; Region: PRK13356
176299002760	homodimer interface [polypeptide binding]; other site
176299002761	substrate-cofactor binding pocket; other site
176299002762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299002763	catalytic residue [active]
176299002764	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299002765	dimerization interface [polypeptide binding]; other site
176299002766	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299002767	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299002768	dimer interface [polypeptide binding]; other site
176299002769	putative CheW interface [polypeptide binding]; other site
176299002770	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299002771	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299002772	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
176299002773	dimerization interface [polypeptide binding]; other site
176299002774	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
176299002775	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299002776	Coenzyme A binding pocket [chemical binding]; other site
176299002777	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
176299002778	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
176299002779	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
176299002780	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
176299002781	active site
176299002782	metal binding site [ion binding]; metal-binding site
176299002783	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
176299002784	Predicted transcriptional regulator [Transcription]; Region: COG2378
176299002785	HTH domain; Region: HTH_11; pfam08279
176299002786	WYL domain; Region: WYL; pfam13280
176299002787	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299002788	Cytochrome c556 [Energy production and conversion]; Region: COG3909
176299002789	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
176299002790	Cytochrome c; Region: Cytochrom_C; pfam00034
176299002791	cobalt transporter subunit CbtB (proposed); Region: CbtB; TIGR02459
176299002792	Predicted integral membrane protein [Function unknown]; Region: COG5446
176299002793	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
176299002794	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
176299002795	conserved cys residue [active]
176299002796	putative acetyltransferase; Provisional; Region: PRK03624
176299002797	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299002798	Coenzyme A binding pocket [chemical binding]; other site
176299002799	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
176299002800	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
176299002801	DNA binding residues [nucleotide binding]
176299002802	dimer interface [polypeptide binding]; other site
176299002803	putative metal binding site [ion binding]; other site
176299002804	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
176299002805	putative metal binding site [ion binding]; other site
176299002806	putative homodimer interface [polypeptide binding]; other site
176299002807	putative homotetramer interface [polypeptide binding]; other site
176299002808	putative homodimer-homodimer interface [polypeptide binding]; other site
176299002809	putative allosteric switch controlling residues; other site
176299002810	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
176299002811	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
176299002812	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
176299002813	Walker A/P-loop; other site
176299002814	ATP binding site [chemical binding]; other site
176299002815	Q-loop/lid; other site
176299002816	ABC transporter signature motif; other site
176299002817	Walker B; other site
176299002818	D-loop; other site
176299002819	H-loop/switch region; other site
176299002820	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
176299002821	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299002822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299002823	dimer interface [polypeptide binding]; other site
176299002824	conserved gate region; other site
176299002825	putative PBP binding loops; other site
176299002826	ABC-ATPase subunit interface; other site
176299002827	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
176299002828	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
176299002829	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
176299002830	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
176299002831	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299002832	inhibitor site; inhibition site
176299002833	active site
176299002834	dimer interface [polypeptide binding]; other site
176299002835	catalytic residue [active]
176299002836	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
176299002837	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
176299002838	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
176299002839	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
176299002840	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
176299002841	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
176299002842	DNA binding site [nucleotide binding]
176299002843	active site
176299002844	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
176299002845	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
176299002846	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
176299002847	putative metal binding site [ion binding]; other site
176299002848	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
176299002849	active site
176299002850	metal binding site [ion binding]; metal-binding site
176299002851	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
176299002852	Ligand Binding Site [chemical binding]; other site
176299002853	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
176299002854	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
176299002855	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299002856	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299002857	Coenzyme A binding pocket [chemical binding]; other site
176299002858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299002859	methionine sulfoxide reductase B; Provisional; Region: PRK00222
176299002860	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
176299002861	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
176299002862	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
176299002863	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
176299002864	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
176299002865	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658
176299002866	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
176299002867	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
176299002868	Multisubunit Na+/H+ antiporter, MnhE subunit [Inorganic ion transport and metabolism]; Region: MnhE; COG1863
176299002869	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
176299002870	Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320
176299002871	Predicted transcriptional regulator [Transcription]; Region: COG4957
176299002872	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
176299002873	DnaA box-binding interface [nucleotide binding]; other site
176299002874	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
176299002875	PAS domain; Region: PAS_9; pfam13426
176299002876	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299002877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299002878	dimer interface [polypeptide binding]; other site
176299002879	phosphorylation site [posttranslational modification]
176299002880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299002881	ATP binding site [chemical binding]; other site
176299002882	Mg2+ binding site [ion binding]; other site
176299002883	G-X-G motif; other site
176299002884	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
176299002885	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299002886	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299002887	Uncharacterized conserved protein [Function unknown]; Region: COG5447
176299002888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
176299002889	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
176299002890	Predicted integral membrane protein [Function unknown]; Region: COG5436
176299002891	Uncharacterized conserved protein [Function unknown]; Region: COG5402
176299002892	Lysine efflux permease [General function prediction only]; Region: COG1279
176299002893	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
176299002894	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299002895	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299002896	dimerization interface [polypeptide binding]; other site
176299002897	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
176299002898	Alginate export; Region: Alginate_exp; pfam13372
176299002899	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
176299002900	Transglycosylase; Region: Transgly; pfam00912
176299002901	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
176299002902	hypothetical protein; Provisional; Region: PRK05170
176299002903	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
176299002904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
176299002905	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
176299002906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299002907	S-adenosylmethionine binding site [chemical binding]; other site
176299002908	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
176299002909	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
176299002910	metal-binding site [ion binding]
176299002911	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
176299002912	Soluble P-type ATPase [General function prediction only]; Region: COG4087
176299002913	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
176299002914	DNA binding residues [nucleotide binding]
176299002915	dimer interface [polypeptide binding]; other site
176299002916	copper binding site [ion binding]; other site
176299002917	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
176299002918	PemK-like protein; Region: PemK; cl00995
176299002919	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
176299002920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299002921	putative substrate translocation pore; other site
176299002922	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
176299002923	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
176299002924	substrate binding [chemical binding]; other site
176299002925	active site
176299002926	hypothetical protein; Validated; Region: PRK00029
176299002927	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
176299002928	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299002929	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299002930	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299002931	putative DNA binding site [nucleotide binding]; other site
176299002932	putative Zn2+ binding site [ion binding]; other site
176299002933	AsnC family; Region: AsnC_trans_reg; pfam01037
176299002934	Predicted transcriptional regulators [Transcription]; Region: COG1733
176299002935	dimerization interface [polypeptide binding]; other site
176299002936	putative DNA binding site [nucleotide binding]; other site
176299002937	putative Zn2+ binding site [ion binding]; other site
176299002938	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
176299002939	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
176299002940	NADP binding site [chemical binding]; other site
176299002941	Predicted membrane protein [Function unknown]; Region: COG4425
176299002942	Alpha/beta-hydrolase family N-terminus; Region: Abhydrolase_9_N; pfam15420
176299002943	Alpha/beta-hydrolase family; Region: Abhydrolase_9; pfam10081
176299002944	Uncharacterized conserved protein [Function unknown]; Region: COG5323
176299002945	Terminase-like family; Region: Terminase_6; pfam03237
176299002946	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
176299002947	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
176299002948	Phage-related protein [Function unknown]; Region: COG4695
176299002949	Phage head maturation protease [General function prediction only]; Region: COG3740
176299002950	Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653
176299002951	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
176299002952	Domain of unknown function (DUF4433); Region: DUF4433; pfam14487
176299002953	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
176299002954	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
176299002955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299002956	putative substrate translocation pore; other site
176299002957	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
176299002958	Phage-related minor tail protein [Function unknown]; Region: COG5281
176299002959	TIGR02217 family protein; Region: chp_TIGR02217
176299002960	Uncharacterized conserved protein [Function unknown]; Region: COG5449
176299002961	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
176299002962	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
176299002963	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
176299002964	putative phage cell wall peptidase, NlpC/P60 family; Region: phage_NlpC_fam; TIGR02219
176299002965	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
176299002966	Putative phage tail protein; Region: Phage-tail_3; pfam13550
176299002967	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299002968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299002969	active site
176299002970	phosphorylation site [posttranslational modification]
176299002971	intermolecular recognition site; other site
176299002972	dimerization interface [polypeptide binding]; other site
176299002973	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299002974	DNA binding site [nucleotide binding]
176299002975	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299002976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299002977	ATP binding site [chemical binding]; other site
176299002978	Mg2+ binding site [ion binding]; other site
176299002979	G-X-G motif; other site
176299002980	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
176299002981	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
176299002982	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
176299002983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299002984	TPR motif; other site
176299002985	binding surface
176299002986	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
176299002987	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
176299002988	Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088
176299002989	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
176299002990	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
176299002991	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
176299002992	protein binding site [polypeptide binding]; other site
176299002993	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
176299002994	protein binding site [polypeptide binding]; other site
176299002995	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299002996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299002997	active site
176299002998	phosphorylation site [posttranslational modification]
176299002999	intermolecular recognition site; other site
176299003000	dimerization interface [polypeptide binding]; other site
176299003001	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299003002	DNA binding site [nucleotide binding]
176299003003	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
176299003004	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299003005	dimerization interface [polypeptide binding]; other site
176299003006	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299003007	dimer interface [polypeptide binding]; other site
176299003008	phosphorylation site [posttranslational modification]
176299003009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299003010	ATP binding site [chemical binding]; other site
176299003011	Mg2+ binding site [ion binding]; other site
176299003012	G-X-G motif; other site
176299003013	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
176299003014	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
176299003015	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
176299003016	metal binding triad; other site
176299003017	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
176299003018	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
176299003019	metal binding triad; other site
176299003020	PAS fold; Region: PAS_3; pfam08447
176299003021	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
176299003022	PAS fold; Region: PAS_7; pfam12860
176299003023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299003024	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
176299003025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299003026	dimer interface [polypeptide binding]; other site
176299003027	phosphorylation site [posttranslational modification]
176299003028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299003029	ATP binding site [chemical binding]; other site
176299003030	Mg2+ binding site [ion binding]; other site
176299003031	G-X-G motif; other site
176299003032	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
176299003033	aminopeptidase N; Provisional; Region: pepN; PRK14015
176299003034	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
176299003035	Zn binding site [ion binding]; other site
176299003036	EamA-like transporter family; Region: EamA; pfam00892
176299003037	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
176299003038	EamA-like transporter family; Region: EamA; pfam00892
176299003039	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
176299003040	Fe-S cluster binding site [ion binding]; other site
176299003041	active site
176299003042	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
176299003043	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
176299003044	nucleotide binding site [chemical binding]; other site
176299003045	putative NEF/HSP70 interaction site [polypeptide binding]; other site
176299003046	SBD interface [polypeptide binding]; other site
176299003047	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299003048	metal binding site [ion binding]; metal-binding site
176299003049	active site
176299003050	I-site; other site
176299003051	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299003052	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
176299003053	putative NAD(P) binding site [chemical binding]; other site
176299003054	putative active site [active]
176299003055	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: COG3965
176299003056	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299003057	EamA-like transporter family; Region: EamA; pfam00892
176299003058	EamA-like transporter family; Region: EamA; pfam00892
176299003059	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299003060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299003061	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
176299003062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299003063	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
176299003064	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
176299003065	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
176299003066	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
176299003067	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
176299003068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
176299003069	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
176299003070	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
176299003071	putative NAD(P) binding site [chemical binding]; other site
176299003072	dimer interface [polypeptide binding]; other site
176299003073	Predicted transcriptional regulators [Transcription]; Region: COG1733
176299003074	dimerization interface [polypeptide binding]; other site
176299003075	putative DNA binding site [nucleotide binding]; other site
176299003076	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299003077	putative Zn2+ binding site [ion binding]; other site
176299003078	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
176299003079	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
176299003080	MgtE intracellular N domain; Region: MgtE_N; smart00924
176299003081	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
176299003082	Divalent cation transporter; Region: MgtE; pfam01769
176299003083	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
176299003084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299003085	putative substrate translocation pore; other site
176299003086	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
176299003087	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
176299003088	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299003089	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299003090	inhibitor-cofactor binding pocket; inhibition site
176299003091	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299003092	catalytic residue [active]
176299003093	Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764
176299003094	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
176299003095	putative active site [active]
176299003096	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
176299003097	AMP nucleosidase; Provisional; Region: PRK08292
176299003098	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
176299003099	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
176299003100	2-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Region: COG2074
176299003101	AAA domain; Region: AAA_17; pfam13207
176299003102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
176299003103	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
176299003104	Sel1-like repeats; Region: SEL1; smart00671
176299003105	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
176299003106	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299003107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299003108	homodimer interface [polypeptide binding]; other site
176299003109	catalytic residue [active]
176299003110	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
176299003111	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299003112	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299003113	Reductase C-terminal; Region: Reductase_C; pfam14759
176299003114	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
176299003115	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
176299003116	Porin subfamily; Region: Porin_2; pfam02530
176299003117	Porin subfamily; Region: Porin_2; pfam02530
176299003118	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
176299003119	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299003120	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299003121	catalytic residue [active]
176299003122	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
176299003123	dimer interface [polypeptide binding]; other site
176299003124	active site
176299003125	catalytic residue [active]
176299003126	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
176299003127	SmpB-tmRNA interface; other site
176299003128	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
176299003129	heme-binding site [chemical binding]; other site
176299003130	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299003131	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299003132	dimer interface [polypeptide binding]; other site
176299003133	putative CheW interface [polypeptide binding]; other site
176299003134	Uncharacterized conserved protein [Function unknown]; Region: COG1432
176299003135	LabA_like proteins; Region: LabA; cd10911
176299003136	putative metal binding site [ion binding]; other site
176299003137	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
176299003138	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
176299003139	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
176299003140	Zn2+ binding site [ion binding]; other site
176299003141	Mg2+ binding site [ion binding]; other site
176299003142	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
176299003143	synthetase active site [active]
176299003144	NTP binding site [chemical binding]; other site
176299003145	metal binding site [ion binding]; metal-binding site
176299003146	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
176299003147	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
176299003148	Protein of unknown function (DUF3563); Region: DUF3563; pfam12086
176299003149	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
176299003150	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
176299003151	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
176299003152	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
176299003153	Catalytic site [active]
176299003154	ribonuclease III; Reviewed; Region: PRK12371
176299003155	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
176299003156	dimerization interface [polypeptide binding]; other site
176299003157	active site
176299003158	metal binding site [ion binding]; metal-binding site
176299003159	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
176299003160	dsRNA binding site [nucleotide binding]; other site
176299003161	GTPase [General function prediction only]; Region: Era; COG1159
176299003162	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
176299003163	G1 box; other site
176299003164	GTP/Mg2+ binding site [chemical binding]; other site
176299003165	Switch I region; other site
176299003166	G2 box; other site
176299003167	Switch II region; other site
176299003168	G3 box; other site
176299003169	G4 box; other site
176299003170	G5 box; other site
176299003171	KH domain; Region: KH_2; pfam07650
176299003172	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299003173	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299003174	ligand binding site [chemical binding]; other site
176299003175	flexible hinge region; other site
176299003176	putative switch regulator; other site
176299003177	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
176299003178	non-specific DNA interactions [nucleotide binding]; other site
176299003179	DNA binding site [nucleotide binding]
176299003180	sequence specific DNA binding site [nucleotide binding]; other site
176299003181	putative cAMP binding site [chemical binding]; other site
176299003182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299003183	active site
176299003184	phosphorylation site [posttranslational modification]
176299003185	intermolecular recognition site; other site
176299003186	dimerization interface [polypeptide binding]; other site
176299003187	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
176299003188	Recombination protein O N terminal; Region: RecO_N; pfam11967
176299003189	Recombination protein O C terminal; Region: RecO_C; pfam02565
176299003190	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299003191	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299003192	putative substrate translocation pore; other site
176299003193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299003194	S-adenosylmethionine binding site [chemical binding]; other site
176299003195	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
176299003196	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
176299003197	MOSC domain; Region: MOSC; pfam03473
176299003198	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
176299003199	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
176299003200	Zn2+ binding site [ion binding]; other site
176299003201	Mg2+ binding site [ion binding]; other site
176299003202	Predicted membrane protein [Function unknown]; Region: COG5373
176299003203	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
176299003204	Zn binding site [ion binding]; other site
176299003205	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
176299003206	Zn binding site [ion binding]; other site
176299003207	Predicted esterase [General function prediction only]; Region: COG0400
176299003208	putative hydrolase; Provisional; Region: PRK11460
176299003209	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299003210	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299003211	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299003212	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299003213	Walker A/P-loop; other site
176299003214	ATP binding site [chemical binding]; other site
176299003215	Q-loop/lid; other site
176299003216	ABC transporter signature motif; other site
176299003217	Walker B; other site
176299003218	D-loop; other site
176299003219	H-loop/switch region; other site
176299003220	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299003221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299003222	dimer interface [polypeptide binding]; other site
176299003223	conserved gate region; other site
176299003224	putative PBP binding loops; other site
176299003225	ABC-ATPase subunit interface; other site
176299003226	Predicted periplasmic or secreted protein [General function prediction only]; Region: COG3443
176299003227	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
176299003228	Conserved TM helix; Region: TM_helix; pfam05552
176299003229	Mechanosensitive ion channel; Region: MS_channel; pfam00924
176299003230	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
176299003231	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
176299003232	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
176299003233	Aminomethyltransferase folate-binding domain; Region: GCV_T; cl01893
176299003234	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
176299003235	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
176299003236	Protein of unknown function (DUF2385); Region: DUF2385; cl11490
176299003237	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
176299003238	nudix motif; other site
176299003239	Uncharacterized conserved protein [Function unknown]; Region: COG1742
176299003240	Uncharacterized conserved protein [Function unknown]; Region: COG2135
176299003241	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
176299003242	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299003243	active site
176299003244	phosphorylation site [posttranslational modification]
176299003245	intermolecular recognition site; other site
176299003246	dimerization interface [polypeptide binding]; other site
176299003247	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299003248	active site
176299003249	phosphorylation site [posttranslational modification]
176299003250	intermolecular recognition site; other site
176299003251	dimerization interface [polypeptide binding]; other site
176299003252	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299003253	metal binding site [ion binding]; metal-binding site
176299003254	active site
176299003255	I-site; other site
176299003256	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
176299003257	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
176299003258	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
176299003259	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299003260	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
176299003261	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
176299003262	Walker A/P-loop; other site
176299003263	ATP binding site [chemical binding]; other site
176299003264	Q-loop/lid; other site
176299003265	ABC transporter signature motif; other site
176299003266	Walker B; other site
176299003267	D-loop; other site
176299003268	H-loop/switch region; other site
176299003269	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
176299003270	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
176299003271	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
176299003272	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
176299003273	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
176299003274	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
176299003275	Predicted permeases [General function prediction only]; Region: RarD; COG2962
176299003276	EamA-like transporter family; Region: EamA; pfam00892
176299003277	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299003278	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
176299003279	Uncharacterized conserved protein [Function unknown]; Region: COG3791
176299003280	Uncharacterized conserved protein [Function unknown]; Region: COG3791
176299003281	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
176299003282	putative active site [active]
176299003283	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
176299003284	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
176299003285	active site
176299003286	HIGH motif; other site
176299003287	KMSKS motif; other site
176299003288	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
176299003289	anticodon binding site; other site
176299003290	tRNA binding surface [nucleotide binding]; other site
176299003291	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299003292	classical (c) SDRs; Region: SDR_c; cd05233
176299003293	NAD(P) binding site [chemical binding]; other site
176299003294	active site
176299003295	amidophosphoribosyltransferase; Provisional; Region: PRK09123
176299003296	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
176299003297	active site
176299003298	tetramer interface [polypeptide binding]; other site
176299003299	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299003300	active site
176299003301	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
176299003302	DNA repair protein RadA; Provisional; Region: PRK11823
176299003303	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
176299003304	Walker A motif/ATP binding site; other site
176299003305	ATP binding site [chemical binding]; other site
176299003306	Walker B motif; other site
176299003307	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
176299003308	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
176299003309	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
176299003310	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
176299003311	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
176299003312	active site
176299003313	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299003314	dimer interface [polypeptide binding]; other site
176299003315	substrate binding site [chemical binding]; other site
176299003316	catalytic residues [active]
176299003317	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
176299003318	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299003319	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299003320	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299003321	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
176299003322	Predicted membrane protein [Function unknown]; Region: COG4541
176299003323	replicative DNA helicase; Provisional; Region: PRK09165
176299003324	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
176299003325	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
176299003326	Walker A motif; other site
176299003327	ATP binding site [chemical binding]; other site
176299003328	Walker B motif; other site
176299003329	DNA binding loops [nucleotide binding]
176299003330	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299003331	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299003332	putative DNA binding site [nucleotide binding]; other site
176299003333	putative Zn2+ binding site [ion binding]; other site
176299003334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299003335	putative substrate translocation pore; other site
176299003336	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
176299003337	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
176299003338	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299003339	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
176299003340	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299003341	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
176299003342	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
176299003343	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
176299003344	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
176299003345	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
176299003346	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299003347	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299003348	active site
176299003349	catalytic tetrad [active]
176299003350	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
176299003351	3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936
176299003352	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
176299003353	NAD(P) binding site [chemical binding]; other site
176299003354	homotetramer interface [polypeptide binding]; other site
176299003355	homodimer interface [polypeptide binding]; other site
176299003356	active site
176299003357	acyl carrier protein; Provisional; Region: acpP; PRK00982
176299003358	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
176299003359	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
176299003360	dimer interface [polypeptide binding]; other site
176299003361	active site
176299003362	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
176299003363	dimerization interface [polypeptide binding]; other site
176299003364	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
176299003365	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
176299003366	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
176299003367	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
176299003368	Guanylate kinase; Region: Guanylate_kin; pfam00625
176299003369	catalytic site [active]
176299003370	G-X2-G-X-G-K; other site
176299003371	Predicted esterase [General function prediction only]; Region: COG0400
176299003372	putative hydrolase; Provisional; Region: PRK11460
176299003373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299003374	S-adenosylmethionine binding site [chemical binding]; other site
176299003375	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
176299003376	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
176299003377	SurA N-terminal domain; Region: SurA_N; pfam09312
176299003378	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
176299003379	Organic solvent tolerance protein; Region: OstA_C; pfam04453
176299003380	Predicted permeases [General function prediction only]; Region: COG0795
176299003381	Predicted permeases [General function prediction only]; Region: COG0795
176299003382	multifunctional aminopeptidase A; Provisional; Region: PRK00913
176299003383	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
176299003384	interface (dimer of trimers) [polypeptide binding]; other site
176299003385	Substrate-binding/catalytic site; other site
176299003386	Zn-binding sites [ion binding]; other site
176299003387	DNA polymerase III subunit chi; Validated; Region: PRK05728
176299003388	GAF domain; Region: GAF; pfam01590
176299003389	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299003390	metal binding site [ion binding]; metal-binding site
176299003391	active site
176299003392	I-site; other site
176299003393	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299003394	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299003395	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
176299003396	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
176299003397	metal binding site [ion binding]; metal-binding site
176299003398	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299003399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299003400	dimer interface [polypeptide binding]; other site
176299003401	phosphorylation site [posttranslational modification]
176299003402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299003403	ATP binding site [chemical binding]; other site
176299003404	Mg2+ binding site [ion binding]; other site
176299003405	G-X-G motif; other site
176299003406	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
176299003407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299003408	active site
176299003409	phosphorylation site [posttranslational modification]
176299003410	intermolecular recognition site; other site
176299003411	dimerization interface [polypeptide binding]; other site
176299003412	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299003413	DNA binding residues [nucleotide binding]
176299003414	dimerization interface [polypeptide binding]; other site
176299003415	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
176299003416	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
176299003417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299003418	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299003419	Walker A/P-loop; other site
176299003420	ATP binding site [chemical binding]; other site
176299003421	ABC transporter signature motif; other site
176299003422	Walker B; other site
176299003423	D-loop; other site
176299003424	ABC transporter; Region: ABC_tran_2; pfam12848
176299003425	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299003426	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299003427	metal binding site [ion binding]; metal-binding site
176299003428	active site
176299003429	I-site; other site
176299003430	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
176299003431	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299003432	putative C-terminal domain interface [polypeptide binding]; other site
176299003433	putative GSH binding site (G-site) [chemical binding]; other site
176299003434	putative dimer interface [polypeptide binding]; other site
176299003435	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
176299003436	putative N-terminal domain interface [polypeptide binding]; other site
176299003437	putative dimer interface [polypeptide binding]; other site
176299003438	putative substrate binding pocket (H-site) [chemical binding]; other site
176299003439	Nucleoside diphosphate kinase; Region: NDK; pfam00334
176299003440	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
176299003441	active site
176299003442	multimer interface [polypeptide binding]; other site
176299003443	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
176299003444	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
176299003445	CGNR zinc finger; Region: zf-CGNR; pfam11706
176299003446	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299003447	TM-ABC transporter signature motif; other site
176299003448	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
176299003449	MoaE homodimer interface [polypeptide binding]; other site
176299003450	MoaD interaction [polypeptide binding]; other site
176299003451	active site residues [active]
176299003452	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
176299003453	MoaE interaction surface [polypeptide binding]; other site
176299003454	MoeB interaction surface [polypeptide binding]; other site
176299003455	thiocarboxylated glycine; other site
176299003456	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
176299003457	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
176299003458	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
176299003459	GIY-YIG motif/motif A; other site
176299003460	active site
176299003461	catalytic site [active]
176299003462	putative DNA binding site [nucleotide binding]; other site
176299003463	metal binding site [ion binding]; metal-binding site
176299003464	UvrB/uvrC motif; Region: UVR; pfam02151
176299003465	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
176299003466	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
176299003467	short chain dehydrogenase; Provisional; Region: PRK09134
176299003468	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299003469	NAD(P) binding site [chemical binding]; other site
176299003470	active site
176299003471	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
176299003472	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299003473	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
176299003474	putative C-terminal domain interface [polypeptide binding]; other site
176299003475	putative GSH binding site (G-site) [chemical binding]; other site
176299003476	putative dimer interface [polypeptide binding]; other site
176299003477	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
176299003478	dimer interface [polypeptide binding]; other site
176299003479	N-terminal domain interface [polypeptide binding]; other site
176299003480	putative substrate binding pocket (H-site) [chemical binding]; other site
176299003481	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
176299003482	B1 nucleotide binding pocket [chemical binding]; other site
176299003483	B2 nucleotide binding pocket [chemical binding]; other site
176299003484	CAS motifs; other site
176299003485	active site
176299003486	Predicted integral membrane protein [Function unknown]; Region: COG0392
176299003487	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
176299003488	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
176299003489	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
176299003490	putative [4Fe-4S] binding site [ion binding]; other site
176299003491	putative molybdopterin cofactor binding site [chemical binding]; other site
176299003492	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
176299003493	putative molybdopterin cofactor binding site; other site
176299003494	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
176299003495	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
176299003496	dimer interface [polypeptide binding]; other site
176299003497	ADP-ribose binding site [chemical binding]; other site
176299003498	active site
176299003499	nudix motif; other site
176299003500	metal binding site [ion binding]; metal-binding site
176299003501	Omptin family; Region: Omptin; cl01886
176299003502	Omptin family; Region: Omptin; cl01886
176299003503	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
176299003504	active site
176299003505	cosubstrate binding site; other site
176299003506	substrate binding site [chemical binding]; other site
176299003507	catalytic site [active]
176299003508	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
176299003509	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
176299003510	dimerization interface [polypeptide binding]; other site
176299003511	putative ATP binding site [chemical binding]; other site
176299003512	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
176299003513	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
176299003514	hypothetical protein; Validated; Region: PRK09087
176299003515	Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855
176299003516	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
176299003517	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
176299003518	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
176299003519	putative domain interface [polypeptide binding]; other site
176299003520	putative active site [active]
176299003521	catalytic site [active]
176299003522	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
176299003523	putative domain interface [polypeptide binding]; other site
176299003524	putative active site [active]
176299003525	catalytic site [active]
176299003526	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
176299003527	exopolyphosphatase; Region: exo_poly_only; TIGR03706
176299003528	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
176299003529	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
176299003530	trimer interface [polypeptide binding]; other site
176299003531	active site
176299003532	substrate binding site [chemical binding]; other site
176299003533	CoA binding site [chemical binding]; other site
176299003534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
176299003535	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
176299003536	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
176299003537	cyclase homology domain; Region: CHD; cd07302
176299003538	nucleotidyl binding site; other site
176299003539	metal binding site [ion binding]; metal-binding site
176299003540	dimer interface [polypeptide binding]; other site
176299003541	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
176299003542	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
176299003543	catalytic site [active]
176299003544	putative active site [active]
176299003545	putative substrate binding site [chemical binding]; other site
176299003546	HRDC domain; Region: HRDC; pfam00570
176299003547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299003548	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299003549	putative substrate translocation pore; other site
176299003550	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
176299003551	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
176299003552	dimer interface [polypeptide binding]; other site
176299003553	anticodon binding site; other site
176299003554	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
176299003555	homodimer interface [polypeptide binding]; other site
176299003556	motif 1; other site
176299003557	active site
176299003558	motif 2; other site
176299003559	GAD domain; Region: GAD; pfam02938
176299003560	motif 3; other site
176299003561	Predicted membrane protein [Function unknown]; Region: COG4129
176299003562	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
176299003563	Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452
176299003564	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
176299003565	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
176299003566	Sulfate transporter family; Region: Sulfate_transp; pfam00916
176299003567	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
176299003568	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
176299003569	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
176299003570	CAP-like domain; other site
176299003571	active site
176299003572	primary dimer interface [polypeptide binding]; other site
176299003573	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
176299003574	Putative arginyl-tRNA:protein arginylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG2935
176299003575	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
176299003576	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
176299003577	Predicted membrane protein/domain [Function unknown]; Region: COG1714
176299003578	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
176299003579	dimer interface [polypeptide binding]; other site
176299003580	allosteric magnesium binding site [ion binding]; other site
176299003581	active site
176299003582	aspartate-rich active site metal binding site; other site
176299003583	Schiff base residues; other site
176299003584	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299003585	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
176299003586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
176299003587	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299003588	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299003589	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
176299003590	dimer interface [polypeptide binding]; other site
176299003591	active site
176299003592	glycine-pyridoxal phosphate binding site [chemical binding]; other site
176299003593	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
176299003594	folate binding site [chemical binding]; other site
176299003595	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
176299003596	ATP cone domain; Region: ATP-cone; pfam03477
176299003597	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
176299003598	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
176299003599	catalytic motif [active]
176299003600	Zn binding site [ion binding]; other site
176299003601	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
176299003602	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
176299003603	Lumazine binding domain; Region: Lum_binding; pfam00677
176299003604	Lumazine binding domain; Region: Lum_binding; pfam00677
176299003605	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299003606	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
176299003607	homopentamer interface [polypeptide binding]; other site
176299003608	active site
176299003609	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
176299003610	putative RNA binding site [nucleotide binding]; other site
176299003611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299003612	putative substrate translocation pore; other site
176299003613	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299003614	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; COG3808
176299003615	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
176299003616	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
176299003617	Uncharacterized conserved protein [Function unknown]; Region: COG5452
176299003618	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
176299003619	putative phosphate acyltransferase; Provisional; Region: PRK05331
176299003620	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
176299003621	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
176299003622	dimer interface [polypeptide binding]; other site
176299003623	active site
176299003624	CoA binding pocket [chemical binding]; other site
176299003625	Alpha subunit of integration host factor (IHFA); Region: IHF_A; cd13835
176299003626	DNA binding site [nucleotide binding]
176299003627	dimer interface [polypeptide binding]; other site
176299003628	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
176299003629	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
176299003630	DNA binding residues [nucleotide binding]
176299003631	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
176299003632	T3/T7-like RNA polymerase; Region: PHA00452
176299003633	DNA-directed RNA polymerase N-terminal; Region: RPOL_N; pfam14700
176299003634	DNA-dependent RNA polymerase; Region: RNA_pol; pfam00940
176299003635	Phage T7 tail fibre protein; Region: Phage_T7_tail; pfam03906
176299003636	Antirestriction protein [General function prediction only]; Region: ArdA; COG4734
176299003637	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299003638	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299003639	integrase; Provisional; Region: int; PHA02601
176299003640	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
176299003641	dimer interface [polypeptide binding]; other site
176299003642	active site
176299003643	catalytic residues [active]
176299003644	Int/Topo IB signature motif; other site
176299003645	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
176299003646	metal-binding site [ion binding]
176299003647	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
176299003648	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
176299003649	metal-binding site [ion binding]
176299003650	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
176299003651	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
176299003652	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299003653	motif II; other site
176299003654	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299003655	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
176299003656	catalytic loop [active]
176299003657	iron binding site [ion binding]; other site
176299003658	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
176299003659	FAD binding pocket [chemical binding]; other site
176299003660	FAD binding motif [chemical binding]; other site
176299003661	phosphate binding motif [ion binding]; other site
176299003662	beta-alpha-beta structure motif; other site
176299003663	NAD binding pocket [chemical binding]; other site
176299003664	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
176299003665	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
176299003666	DNA binding residues [nucleotide binding]
176299003667	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299003668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299003669	dimer interface [polypeptide binding]; other site
176299003670	conserved gate region; other site
176299003671	putative PBP binding loops; other site
176299003672	ABC-ATPase subunit interface; other site
176299003673	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299003674	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299003675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299003676	dimer interface [polypeptide binding]; other site
176299003677	conserved gate region; other site
176299003678	putative PBP binding loops; other site
176299003679	ABC-ATPase subunit interface; other site
176299003680	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
176299003681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299003682	Walker A/P-loop; other site
176299003683	ATP binding site [chemical binding]; other site
176299003684	Q-loop/lid; other site
176299003685	ABC transporter signature motif; other site
176299003686	Walker B; other site
176299003687	D-loop; other site
176299003688	H-loop/switch region; other site
176299003689	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299003690	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
176299003691	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299003692	Walker A/P-loop; other site
176299003693	ATP binding site [chemical binding]; other site
176299003694	Q-loop/lid; other site
176299003695	ABC transporter signature motif; other site
176299003696	Walker B; other site
176299003697	D-loop; other site
176299003698	H-loop/switch region; other site
176299003699	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299003700	putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755
176299003701	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
176299003702	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
176299003703	metal-binding site [ion binding]
176299003704	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
176299003705	Cation transport protein; Region: TrkH; cl17365
176299003706	threonine dehydratase; Validated; Region: PRK08639
176299003707	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
176299003708	tetramer interface [polypeptide binding]; other site
176299003709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299003710	catalytic residue [active]
176299003711	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
176299003712	Uncharacterized conserved protein [Function unknown]; Region: COG5453
176299003713	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299003714	metal binding site [ion binding]; metal-binding site
176299003715	active site
176299003716	I-site; other site
176299003717	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
176299003718	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299003719	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299003720	LysR substrate binding domain; Region: LysR_substrate; pfam03466
176299003721	dimerization interface [polypeptide binding]; other site
176299003722	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
176299003723	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
176299003724	active site
176299003725	metal binding site [ion binding]; metal-binding site
176299003726	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
176299003727	PilZ domain; Region: PilZ; pfam07238
176299003728	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
176299003729	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
176299003730	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
176299003731	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
176299003732	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
176299003733	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
176299003734	active site residue [active]
176299003735	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
176299003736	active site residue [active]
176299003737	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
176299003738	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
176299003739	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
176299003740	cysteine synthase; Region: PLN02565
176299003741	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
176299003742	dimer interface [polypeptide binding]; other site
176299003743	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299003744	catalytic residue [active]
176299003745	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
176299003746	DNA photolyase; Region: DNA_photolyase; pfam00875
176299003747	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
176299003748	Protein of unknown function (DUF982); Region: DUF982; pfam06169
176299003749	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
176299003750	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
176299003751	DNA binding site [nucleotide binding]
176299003752	active site
176299003753	TIGR02594 family protein; Region: TIGR02594
176299003754	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
176299003755	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
176299003756	Predicted membrane protein [Function unknown]; Region: COG1238
176299003757	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
176299003758	Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170
176299003759	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
176299003760	O-Antigen ligase; Region: Wzy_C; pfam04932
176299003761	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
176299003762	CoA-binding domain; Region: CoA_binding_3; pfam13727
176299003763	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
176299003764	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299003765	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
176299003766	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
176299003767	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
176299003768	SLBB domain; Region: SLBB; pfam10531
176299003769	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
176299003770	Chain length determinant protein; Region: Wzz; pfam02706
176299003771	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
176299003772	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299003773	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
176299003774	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
176299003775	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
176299003776	Streptomycin 6-kinase [Defense mechanisms]; Region: StrB; COG3570
176299003777	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
176299003778	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
176299003779	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
176299003780	oligomer interface [polypeptide binding]; other site
176299003781	putative active site [active]
176299003782	Mn binding site [ion binding]; other site
176299003783	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
176299003784	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
176299003785	23S rRNA interface [nucleotide binding]; other site
176299003786	L3 interface [polypeptide binding]; other site
176299003787	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
176299003788	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
176299003789	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
176299003790	homodimer interface [polypeptide binding]; other site
176299003791	substrate-cofactor binding pocket; other site
176299003792	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299003793	catalytic residue [active]
176299003794	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
176299003795	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299003796	dimerization interface [polypeptide binding]; other site
176299003797	putative DNA binding site [nucleotide binding]; other site
176299003798	putative Zn2+ binding site [ion binding]; other site
176299003799	short chain dehydrogenase; Provisional; Region: PRK06500
176299003800	classical (c) SDRs; Region: SDR_c; cd05233
176299003801	NAD(P) binding site [chemical binding]; other site
176299003802	active site
176299003803	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
176299003804	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299003805	metal binding site [ion binding]; metal-binding site
176299003806	active site
176299003807	I-site; other site
176299003808	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
176299003809	oligomer interface [polypeptide binding]; other site
176299003810	active site residues [active]
176299003811	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
176299003812	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
176299003813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299003814	Walker A motif; other site
176299003815	ATP binding site [chemical binding]; other site
176299003816	Walker B motif; other site
176299003817	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
176299003818	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
176299003819	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
176299003820	Learning-associated protein; Region: Laps; pfam10169
176299003821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299003822	Walker A motif; other site
176299003823	ATP binding site [chemical binding]; other site
176299003824	Walker B motif; other site
176299003825	arginine finger; other site
176299003826	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
176299003827	histone-like DNA-binding protein HU; Region: HU; cd13831
176299003828	dimer interface [polypeptide binding]; other site
176299003829	DNA binding site [nucleotide binding]
176299003830	Uncharacterized conserved protein [Function unknown]; Region: COG3391
176299003831	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
176299003832	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
176299003833	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
176299003834	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
176299003835	Uncharacterized conserved protein [Function unknown]; Region: COG3791
176299003836	NADH dehydrogenase subunit D; Validated; Region: PRK06075
176299003837	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
176299003838	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
176299003839	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
176299003840	putative dimer interface [polypeptide binding]; other site
176299003841	[2Fe-2S] cluster binding site [ion binding]; other site
176299003842	Uncharacterized conserved protein [Function unknown]; Region: COG3743
176299003843	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
176299003844	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
176299003845	SLBB domain; Region: SLBB; pfam10531
176299003846	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
176299003847	NADH dehydrogenase subunit G; Validated; Region: PRK09130
176299003848	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299003849	catalytic loop [active]
176299003850	iron binding site [ion binding]; other site
176299003851	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
176299003852	MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773
176299003853	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
176299003854	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
176299003855	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
176299003856	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
176299003857	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
176299003858	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
176299003859	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
176299003860	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
176299003861	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
176299003862	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
176299003863	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
176299003864	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
176299003865	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
176299003866	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
176299003867	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
176299003868	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
176299003869	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
176299003870	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
176299003871	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
176299003872	RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
176299003873	Predicted secreted protein [Function unknown]; Region: COG5454
176299003874	prolyl-tRNA synthetase; Provisional; Region: PRK12325
176299003875	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
176299003876	dimer interface [polypeptide binding]; other site
176299003877	motif 1; other site
176299003878	active site
176299003879	motif 2; other site
176299003880	motif 3; other site
176299003881	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
176299003882	anticodon binding site; other site
176299003883	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
176299003884	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
176299003885	FtsX-like permease family; Region: FtsX; pfam02687
176299003886	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
176299003887	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
176299003888	Walker A/P-loop; other site
176299003889	ATP binding site [chemical binding]; other site
176299003890	Q-loop/lid; other site
176299003891	ABC transporter signature motif; other site
176299003892	Walker B; other site
176299003893	D-loop; other site
176299003894	H-loop/switch region; other site
176299003895	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
176299003896	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
176299003897	putative active site [active]
176299003898	putative PHP Thumb interface [polypeptide binding]; other site
176299003899	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
176299003900	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
176299003901	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
176299003902	generic binding surface II; other site
176299003903	generic binding surface I; other site
176299003904	hypothetical protein; Provisional; Region: PRK06132
176299003905	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299003906	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299003907	DNA polymerase IV; Provisional; Region: PRK02794
176299003908	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
176299003909	active site
176299003910	DNA binding site [nucleotide binding]
176299003911	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
176299003912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299003913	active site
176299003914	phosphorylation site [posttranslational modification]
176299003915	intermolecular recognition site; other site
176299003916	dimerization interface [polypeptide binding]; other site
176299003917	response regulator PleD; Reviewed; Region: pleD; PRK09581
176299003918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299003919	active site
176299003920	phosphorylation site [posttranslational modification]
176299003921	intermolecular recognition site; other site
176299003922	dimerization interface [polypeptide binding]; other site
176299003923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
176299003924	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299003925	metal binding site [ion binding]; metal-binding site
176299003926	active site
176299003927	I-site; other site
176299003928	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
176299003929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299003930	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299003931	putative substrate translocation pore; other site
176299003932	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
176299003933	nudix motif; other site
176299003934	hypothetical protein; Provisional; Region: PRK05978
176299003935	ribonuclease R; Region: RNase_R; TIGR02063
176299003936	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
176299003937	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
176299003938	RNA binding site [nucleotide binding]; other site
176299003939	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
176299003940	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
176299003941	active site
176299003942	interdomain interaction site; other site
176299003943	putative metal-binding site [ion binding]; other site
176299003944	nucleotide binding site [chemical binding]; other site
176299003945	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
176299003946	domain I; other site
176299003947	DNA binding groove [nucleotide binding]
176299003948	phosphate binding site [ion binding]; other site
176299003949	domain II; other site
176299003950	domain III; other site
176299003951	nucleotide binding site [chemical binding]; other site
176299003952	catalytic site [active]
176299003953	domain IV; other site
176299003954	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
176299003955	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
176299003956	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
176299003957	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
176299003958	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
176299003959	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
176299003960	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
176299003961	dihydroorotase; Validated; Region: PRK09059
176299003962	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
176299003963	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
176299003964	active site
176299003965	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
176299003966	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
176299003967	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
176299003968	Domain of unknown function (DUF4440); Region: DUF4440; pfam14534
176299003969	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
176299003970	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
176299003971	active site
176299003972	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299003973	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
176299003974	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
176299003975	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299003976	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299003977	Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816
176299003978	metal-dependent hydrolase; Provisional; Region: PRK00685
176299003979	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
176299003980	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
176299003981	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
176299003982	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299003983	Coenzyme A binding pocket [chemical binding]; other site
176299003984	Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857
176299003985	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299003986	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
176299003987	Coenzyme A binding pocket [chemical binding]; other site
176299003988	Predicted membrane protein [Function unknown]; Region: COG3326
176299003989	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
176299003990	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
176299003991	GatB domain; Region: GatB_Yqey; smart00845
176299003992	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299003993	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299003994	Coenzyme A binding pocket [chemical binding]; other site
176299003995	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299003996	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299003997	Coenzyme A binding pocket [chemical binding]; other site
176299003998	NADH dehydrogenase; Validated; Region: PRK08183
176299003999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4765
176299004000	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
176299004001	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
176299004002	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299004003	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
176299004004	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
176299004005	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
176299004006	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
176299004007	carboxyltransferase (CT) interaction site; other site
176299004008	biotinylation site [posttranslational modification]; other site
176299004009	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
176299004010	trimer interface [polypeptide binding]; other site
176299004011	active site
176299004012	dimer interface [polypeptide binding]; other site
176299004013	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
176299004014	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
176299004015	catalytic residues [active]
176299004016	aspartate aminotransferase; Provisional; Region: PRK05764
176299004017	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299004018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299004019	homodimer interface [polypeptide binding]; other site
176299004020	catalytic residue [active]
176299004021	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299004022	dimerization interface [polypeptide binding]; other site
176299004023	putative DNA binding site [nucleotide binding]; other site
176299004024	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299004025	putative Zn2+ binding site [ion binding]; other site
176299004026	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
176299004027	ATP binding site [chemical binding]; other site
176299004028	NIPSNAP; Region: NIPSNAP; pfam07978
176299004029	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
176299004030	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
176299004031	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
176299004032	putative NAD(P) binding site [chemical binding]; other site
176299004033	putative active site [active]
176299004034	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
176299004035	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
176299004036	RNA binding site [nucleotide binding]; other site
176299004037	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
176299004038	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
176299004039	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
176299004040	AMIN domain; Region: AMIN; pfam11741
176299004041	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
176299004042	active site
176299004043	metal binding site [ion binding]; metal-binding site
176299004044	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
176299004045	Transglycosylase; Region: Transgly; pfam00912
176299004046	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
176299004047	peptide chain release factor 2; Provisional; Region: PRK07342
176299004048	This domain is found in peptide chain release factors; Region: PCRF; smart00937
176299004049	RF-1 domain; Region: RF-1; pfam00472
176299004050	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
176299004051	catalytic triad [active]
176299004052	conserved cis-peptide bond; other site
176299004053	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
176299004054	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
176299004055	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
176299004056	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
176299004057	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
176299004058	G1 box; other site
176299004059	GTP/Mg2+ binding site [chemical binding]; other site
176299004060	G2 box; other site
176299004061	Switch I region; other site
176299004062	G3 box; other site
176299004063	Switch II region; other site
176299004064	G4 box; other site
176299004065	G5 box; other site
176299004066	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
176299004067	Elongation Factor G, domain II; Region: EFG_II; pfam14492
176299004068	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
176299004069	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
176299004070	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
176299004071	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
176299004072	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299004073	catalytic loop [active]
176299004074	iron binding site [ion binding]; other site
176299004075	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5661
176299004076	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
176299004077	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
176299004078	substrate binding pocket [chemical binding]; other site
176299004079	dimer interface [polypeptide binding]; other site
176299004080	inhibitor binding site; inhibition site
176299004081	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
176299004082	homooctamer interface [polypeptide binding]; other site
176299004083	active site
176299004084	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
176299004085	catalytic center binding site [active]
176299004086	ATP binding site [chemical binding]; other site
176299004087	Predicted membrane protein [Function unknown]; Region: COG3768
176299004088	TIGR01620 family protein; Region: hyp_HI0043
176299004089	Predicted ATPase [General function prediction only]; Region: COG3106
176299004090	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
176299004091	catalytic core [active]
176299004092	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
176299004093	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
176299004094	PAS domain; Region: PAS_9; pfam13426
176299004095	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299004096	PAS domain; Region: PAS; smart00091
176299004097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299004098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299004099	dimer interface [polypeptide binding]; other site
176299004100	phosphorylation site [posttranslational modification]
176299004101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299004102	ATP binding site [chemical binding]; other site
176299004103	Mg2+ binding site [ion binding]; other site
176299004104	G-X-G motif; other site
176299004105	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299004106	active site
176299004107	phosphorylation site [posttranslational modification]
176299004108	intermolecular recognition site; other site
176299004109	dimerization interface [polypeptide binding]; other site
176299004110	Uncharacterized conserved protein [Function unknown]; Region: COG2127
176299004111	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
176299004112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299004113	Walker A motif; other site
176299004114	ATP binding site [chemical binding]; other site
176299004115	Walker B motif; other site
176299004116	arginine finger; other site
176299004117	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299004118	Walker A motif; other site
176299004119	ATP binding site [chemical binding]; other site
176299004120	Walker B motif; other site
176299004121	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
176299004122	AzlC protein; Region: AzlC; pfam03591
176299004123	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
176299004124	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299004125	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299004126	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299004127	dimerization interface [polypeptide binding]; other site
176299004128	Uncharacterized conserved protein [Function unknown]; Region: COG3665
176299004129	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
176299004130	HIT family signature motif; other site
176299004131	catalytic residue [active]
176299004132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
176299004133	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
176299004134	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_3; cd08585
176299004135	putative active site [active]
176299004136	catalytic site [active]
176299004137	putative metal binding site [ion binding]; other site
176299004138	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
176299004139	homotrimer interaction site [polypeptide binding]; other site
176299004140	putative active site [active]
176299004141	Domain of unknown function (DUF1849); Region: DUF1849; pfam08904
176299004142	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
176299004143	rRNA interaction site [nucleotide binding]; other site
176299004144	S8 interaction site; other site
176299004145	putative laminin-1 binding site; other site
176299004146	elongation factor Ts; Provisional; Region: tsf; PRK09377
176299004147	UBA/TS-N domain; Region: UBA; pfam00627
176299004148	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
176299004149	putative nucleotide binding site [chemical binding]; other site
176299004150	uridine monophosphate binding site [chemical binding]; other site
176299004151	homohexameric interface [polypeptide binding]; other site
176299004152	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
176299004153	hinge region; other site
176299004154	Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
176299004155	active site
176299004156	dimer interface [polypeptide binding]; other site
176299004157	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
176299004158	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
176299004159	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
176299004160	active site
176299004161	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
176299004162	protein binding site [polypeptide binding]; other site
176299004163	putative substrate binding region [chemical binding]; other site
176299004164	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
176299004165	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
176299004166	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
176299004167	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
176299004168	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
176299004169	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
176299004170	Surface antigen; Region: Bac_surface_Ag; pfam01103
176299004171	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
176299004172	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
176299004173	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
176299004174	trimer interface [polypeptide binding]; other site
176299004175	active site
176299004176	UDP-GlcNAc binding site [chemical binding]; other site
176299004177	lipid binding site [chemical binding]; lipid-binding site
176299004178	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
176299004179	Acyl-[acyl carrier protein]; Region: LpxA; COG1043
176299004180	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
176299004181	active site
176299004182	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3494
176299004183	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
176299004184	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
176299004185	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299004186	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299004187	DNA-binding site [nucleotide binding]; DNA binding site
176299004188	FCD domain; Region: FCD; pfam07729
176299004189	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299004190	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299004191	substrate binding pocket [chemical binding]; other site
176299004192	membrane-bound complex binding site; other site
176299004193	hinge residues; other site
176299004194	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299004195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004196	dimer interface [polypeptide binding]; other site
176299004197	conserved gate region; other site
176299004198	putative PBP binding loops; other site
176299004199	ABC-ATPase subunit interface; other site
176299004200	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299004201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004202	dimer interface [polypeptide binding]; other site
176299004203	conserved gate region; other site
176299004204	putative PBP binding loops; other site
176299004205	ABC-ATPase subunit interface; other site
176299004206	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299004207	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299004208	Walker A/P-loop; other site
176299004209	ATP binding site [chemical binding]; other site
176299004210	Q-loop/lid; other site
176299004211	ABC transporter signature motif; other site
176299004212	Walker B; other site
176299004213	D-loop; other site
176299004214	H-loop/switch region; other site
176299004215	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
176299004216	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
176299004217	dimer interface [polypeptide binding]; other site
176299004218	active site
176299004219	citrylCoA binding site [chemical binding]; other site
176299004220	NADH binding [chemical binding]; other site
176299004221	cationic pore residues; other site
176299004222	oxalacetate/citrate binding site [chemical binding]; other site
176299004223	coenzyme A binding site [chemical binding]; other site
176299004224	catalytic triad [active]
176299004225	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
176299004226	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
176299004227	Competence protein; Region: Competence; pfam03772
176299004228	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
176299004229	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299004230	putative C-terminal domain interface [polypeptide binding]; other site
176299004231	putative GSH binding site (G-site) [chemical binding]; other site
176299004232	putative dimer interface [polypeptide binding]; other site
176299004233	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
176299004234	putative N-terminal domain interface [polypeptide binding]; other site
176299004235	putative dimer interface [polypeptide binding]; other site
176299004236	putative substrate binding pocket (H-site) [chemical binding]; other site
176299004237	LexA repressor; Validated; Region: PRK00215
176299004238	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
176299004239	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
176299004240	Catalytic site [active]
176299004241	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299004242	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299004243	Walker A/P-loop; other site
176299004244	ATP binding site [chemical binding]; other site
176299004245	Q-loop/lid; other site
176299004246	ABC transporter signature motif; other site
176299004247	Walker B; other site
176299004248	D-loop; other site
176299004249	H-loop/switch region; other site
176299004250	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299004251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004252	dimer interface [polypeptide binding]; other site
176299004253	conserved gate region; other site
176299004254	putative PBP binding loops; other site
176299004255	ABC-ATPase subunit interface; other site
176299004256	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299004257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004258	dimer interface [polypeptide binding]; other site
176299004259	conserved gate region; other site
176299004260	putative PBP binding loops; other site
176299004261	ABC-ATPase subunit interface; other site
176299004262	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299004263	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299004264	substrate binding pocket [chemical binding]; other site
176299004265	membrane-bound complex binding site; other site
176299004266	hinge residues; other site
176299004267	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299004268	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165
176299004269	putative ligand binding site [chemical binding]; other site
176299004270	NAD binding site [chemical binding]; other site
176299004271	dimer interface [polypeptide binding]; other site
176299004272	putative catalytic site [active]
176299004273	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299004274	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299004275	Walker A/P-loop; other site
176299004276	ATP binding site [chemical binding]; other site
176299004277	Q-loop/lid; other site
176299004278	ABC transporter signature motif; other site
176299004279	Walker B; other site
176299004280	D-loop; other site
176299004281	H-loop/switch region; other site
176299004282	TOBE domain; Region: TOBE_2; pfam08402
176299004283	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299004284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004285	dimer interface [polypeptide binding]; other site
176299004286	conserved gate region; other site
176299004287	putative PBP binding loops; other site
176299004288	ABC-ATPase subunit interface; other site
176299004289	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299004290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004291	dimer interface [polypeptide binding]; other site
176299004292	conserved gate region; other site
176299004293	putative PBP binding loops; other site
176299004294	ABC-ATPase subunit interface; other site
176299004295	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299004296	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299004297	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299004298	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
176299004299	DNA-binding site [nucleotide binding]; DNA binding site
176299004300	FCD domain; Region: FCD; pfam07729
176299004301	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299004302	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
176299004303	active site pocket [active]
176299004304	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
176299004305	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299004306	NAD(P) binding site [chemical binding]; other site
176299004307	active site
176299004308	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
176299004309	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
176299004310	putative NAD(P) binding site [chemical binding]; other site
176299004311	catalytic Zn binding site [ion binding]; other site
176299004312	ureidoglycolate hydrolase; Provisional; Region: PRK13395
176299004313	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
176299004314	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
176299004315	Walker A/P-loop; other site
176299004316	ATP binding site [chemical binding]; other site
176299004317	Q-loop/lid; other site
176299004318	ABC transporter signature motif; other site
176299004319	Walker B; other site
176299004320	D-loop; other site
176299004321	H-loop/switch region; other site
176299004322	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
176299004323	TM-ABC transporter signature motif; other site
176299004324	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
176299004325	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
176299004326	Walker A/P-loop; other site
176299004327	ATP binding site [chemical binding]; other site
176299004328	Q-loop/lid; other site
176299004329	ABC transporter signature motif; other site
176299004330	Walker B; other site
176299004331	D-loop; other site
176299004332	H-loop/switch region; other site
176299004333	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299004334	TM-ABC transporter signature motif; other site
176299004335	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299004336	Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333
176299004337	putative ligand binding site [chemical binding]; other site
176299004338	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299004339	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
176299004340	FAD binding site [chemical binding]; other site
176299004341	substrate binding site [chemical binding]; other site
176299004342	catalytic residues [active]
176299004343	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
176299004344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299004345	NAD(P) binding site [chemical binding]; other site
176299004346	active site
176299004347	feruloyl-CoA synthase; Reviewed; Region: PRK08180
176299004348	Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921
176299004349	acyl-activating enzyme (AAE) consensus motif; other site
176299004350	putative AMP binding site [chemical binding]; other site
176299004351	putative active site [active]
176299004352	putative CoA binding site [chemical binding]; other site
176299004353	enoyl-CoA hydratase; Provisional; Region: PRK08150
176299004354	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
176299004355	substrate binding site [chemical binding]; other site
176299004356	oxyanion hole (OAH) forming residues; other site
176299004357	trimer interface [polypeptide binding]; other site
176299004358	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
176299004359	FAD binding site [chemical binding]; other site
176299004360	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299004361	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299004362	DNA-binding site [nucleotide binding]; DNA binding site
176299004363	FCD domain; Region: FCD; pfam07729
176299004364	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
176299004365	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
176299004366	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
176299004367	active site
176299004368	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299004369	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299004370	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
176299004371	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877
176299004372	enolase; Provisional; Region: eno; PRK00077
176299004373	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
176299004374	dimer interface [polypeptide binding]; other site
176299004375	metal binding site [ion binding]; metal-binding site
176299004376	substrate binding pocket [chemical binding]; other site
176299004377	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
176299004378	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
176299004379	tetramer interface [polypeptide binding]; other site
176299004380	TPP-binding site [chemical binding]; other site
176299004381	heterodimer interface [polypeptide binding]; other site
176299004382	phosphorylation loop region [posttranslational modification]
176299004383	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
176299004384	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
176299004385	E3 interaction surface; other site
176299004386	lipoyl attachment site [posttranslational modification]; other site
176299004387	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
176299004388	alpha subunit interface [polypeptide binding]; other site
176299004389	TPP binding site [chemical binding]; other site
176299004390	heterodimer interface [polypeptide binding]; other site
176299004391	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
176299004392	2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347
176299004393	50S ribosomal protein L12P; Region: L12P_arch; TIGR03685
176299004394	e3 binding domain; Region: E3_binding; pfam02817
176299004395	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
176299004396	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
176299004397	active site
176299004398	catalytic triad [active]
176299004399	oxyanion hole [active]
176299004400	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
176299004401	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299004402	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299004403	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
176299004404	Predicted membrane protein [Function unknown]; Region: COG2261
176299004405	lipoyl synthase; Provisional; Region: PRK05481
176299004406	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299004407	FeS/SAM binding site; other site
176299004408	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299004409	Multidrug resistance efflux transporter; Region: EmrE; cl19304
176299004410	Cupin domain; Region: Cupin_2; cl17218
176299004411	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299004412	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299004413	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299004414	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
176299004415	AAA domain; Region: AAA_17; cl19128
176299004416	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
176299004417	putative coenzyme Q binding site [chemical binding]; other site
176299004418	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
176299004419	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
176299004420	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
176299004421	substrate binding site; other site
176299004422	dimer interface; other site
176299004423	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
176299004424	homotrimer interaction site [polypeptide binding]; other site
176299004425	zinc binding site [ion binding]; other site
176299004426	CDP-binding sites; other site
176299004427	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
176299004428	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
176299004429	FMN binding site [chemical binding]; other site
176299004430	active site
176299004431	catalytic residues [active]
176299004432	substrate binding site [chemical binding]; other site
176299004433	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
176299004434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299004435	dimer interface [polypeptide binding]; other site
176299004436	phosphorylation site [posttranslational modification]
176299004437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299004438	ATP binding site [chemical binding]; other site
176299004439	Mg2+ binding site [ion binding]; other site
176299004440	G-X-G motif; other site
176299004441	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
176299004442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299004443	active site
176299004444	phosphorylation site [posttranslational modification]
176299004445	intermolecular recognition site; other site
176299004446	dimerization interface [polypeptide binding]; other site
176299004447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299004448	Walker A motif; other site
176299004449	ATP binding site [chemical binding]; other site
176299004450	Walker B motif; other site
176299004451	arginine finger; other site
176299004452	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
176299004453	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
176299004454	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299004455	dimerization interface [polypeptide binding]; other site
176299004456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299004457	putative active site [active]
176299004458	heme pocket [chemical binding]; other site
176299004459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299004460	dimer interface [polypeptide binding]; other site
176299004461	phosphorylation site [posttranslational modification]
176299004462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299004463	ATP binding site [chemical binding]; other site
176299004464	Mg2+ binding site [ion binding]; other site
176299004465	G-X-G motif; other site
176299004466	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
176299004467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299004468	active site
176299004469	phosphorylation site [posttranslational modification]
176299004470	intermolecular recognition site; other site
176299004471	dimerization interface [polypeptide binding]; other site
176299004472	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299004473	Walker A motif; other site
176299004474	ATP binding site [chemical binding]; other site
176299004475	Walker B motif; other site
176299004476	arginine finger; other site
176299004477	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
176299004478	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
176299004479	TrkA-N domain; Region: TrkA_N; pfam02254
176299004480	TrkA-C domain; Region: TrkA_C; pfam02080
176299004481	TrkA-N domain; Region: TrkA_N; pfam02254
176299004482	TrkA-C domain; Region: TrkA_C; pfam02080
176299004483	bacterial Hfq-like; Region: Hfq; cd01716
176299004484	hexamer interface [polypeptide binding]; other site
176299004485	Sm1 motif; other site
176299004486	RNA binding site [nucleotide binding]; other site
176299004487	Sm2 motif; other site
176299004488	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
176299004489	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
176299004490	HflX GTPase family; Region: HflX; cd01878
176299004491	G1 box; other site
176299004492	GTP/Mg2+ binding site [chemical binding]; other site
176299004493	Switch I region; other site
176299004494	G2 box; other site
176299004495	G3 box; other site
176299004496	Switch II region; other site
176299004497	G4 box; other site
176299004498	G5 box; other site
176299004499	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
176299004500	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
176299004501	homodimer interface [polypeptide binding]; other site
176299004502	metal binding site [ion binding]; metal-binding site
176299004503	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
176299004504	homodimer interface [polypeptide binding]; other site
176299004505	active site
176299004506	putative chemical substrate binding site [chemical binding]; other site
176299004507	metal binding site [ion binding]; metal-binding site
176299004508	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
176299004509	nucleoside/Zn binding site; other site
176299004510	dimer interface [polypeptide binding]; other site
176299004511	catalytic motif [active]
176299004512	siroheme synthase; Provisional; Region: cysG; PRK10637
176299004513	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
176299004514	Sirohaem biosynthesis protein central; Region: Sirohm_synth_M; pfam14824
176299004515	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
176299004516	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
176299004517	active site
176299004518	SAM binding site [chemical binding]; other site
176299004519	homodimer interface [polypeptide binding]; other site
176299004520	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
176299004521	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
176299004522	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
176299004523	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
176299004524	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
176299004525	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
176299004526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3749
176299004527	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
176299004528	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
176299004529	FAD binding pocket [chemical binding]; other site
176299004530	FAD binding motif [chemical binding]; other site
176299004531	phosphate binding motif [ion binding]; other site
176299004532	beta-alpha-beta structure motif; other site
176299004533	NAD binding pocket [chemical binding]; other site
176299004534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299004535	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299004536	putative substrate translocation pore; other site
176299004537	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
176299004538	putative catalytic site [active]
176299004539	putative metal binding site [ion binding]; other site
176299004540	putative phosphate binding site [ion binding]; other site
176299004541	glycine dehydrogenase; Provisional; Region: PRK05367
176299004542	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
176299004543	tetramer interface [polypeptide binding]; other site
176299004544	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299004545	catalytic residue [active]
176299004546	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
176299004547	tetramer interface [polypeptide binding]; other site
176299004548	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299004549	catalytic residue [active]
176299004550	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
176299004551	lipoyl attachment site [posttranslational modification]; other site
176299004552	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
176299004553	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
176299004554	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
176299004555	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
176299004556	Copper(I)-binding protein [Inorganic ion transport and    metabolism]; Region: COG2847
176299004557	camphor resistance protein CrcB; Provisional; Region: PRK14195
176299004558	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
176299004559	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
176299004560	RNA binding surface [nucleotide binding]; other site
176299004561	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
176299004562	active site
176299004563	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
176299004564	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299004565	active site
176299004566	motif I; other site
176299004567	motif II; other site
176299004568	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
176299004569	Chaperone required for the assembly of the mitochondrial F1-ATPase [Posttranslational modification, protein turnover, chaperones]; Region: COG5387
176299004570	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
176299004571	homotrimer interaction site [polypeptide binding]; other site
176299004572	putative active site [active]
176299004573	Predicted esterase [General function prediction only]; Region: COG0627
176299004574	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
176299004575	Predicted membrane protein [Function unknown]; Region: COG4291
176299004576	hypothetical protein; Validated; Region: PRK00124
176299004577	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
176299004578	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
176299004579	dimer interface [polypeptide binding]; other site
176299004580	decamer (pentamer of dimers) interface [polypeptide binding]; other site
176299004581	catalytic triad [active]
176299004582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4332
176299004583	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
176299004584	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
176299004585	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
176299004586	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299004587	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299004588	DNA binding residues [nucleotide binding]
176299004589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
176299004590	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
176299004591	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
176299004592	Uncharacterized conserved protein [Function unknown]; Region: COG2353
176299004593	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
176299004594	Helix-turn-helix domain; Region: HTH_38; pfam13936
176299004595	DNA-binding interface [nucleotide binding]; DNA binding site
176299004596	Homeodomain-like domain; Region: HTH_32; pfam13565
176299004597	Integrase core domain; Region: rve; pfam00665
176299004598	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
176299004599	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
176299004600	catalytic residues [active]
176299004601	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
176299004602	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299004603	dimerization interface [polypeptide binding]; other site
176299004604	putative DNA binding site [nucleotide binding]; other site
176299004605	putative Zn2+ binding site [ion binding]; other site
176299004606	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
176299004607	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
176299004608	Cl- selectivity filter; other site
176299004609	Cl- binding residues [ion binding]; other site
176299004610	pore gating glutamate residue; other site
176299004611	dimer interface [polypeptide binding]; other site
176299004612	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
176299004613	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
176299004614	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
176299004615	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
176299004616	active site
176299004617	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
176299004618	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
176299004619	active site
176299004620	HIGH motif; other site
176299004621	KMSKS motif; other site
176299004622	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
176299004623	tRNA binding surface [nucleotide binding]; other site
176299004624	anticodon binding site; other site
176299004625	DNA polymerase III subunit delta'; Validated; Region: PRK09112
176299004626	DNA polymerase III subunit delta'; Validated; Region: PRK08485
176299004627	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
176299004628	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
176299004629	TMP-binding site; other site
176299004630	ATP-binding site [chemical binding]; other site
176299004631	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
176299004632	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
176299004633	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
176299004634	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
176299004635	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
176299004636	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
176299004637	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
176299004638	Sporulation related domain; Region: SPOR; pfam05036
176299004639	DNA gyrase subunit A; Validated; Region: PRK05560
176299004640	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
176299004641	CAP-like domain; other site
176299004642	active site
176299004643	primary dimer interface [polypeptide binding]; other site
176299004644	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
176299004645	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
176299004646	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
176299004647	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
176299004648	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
176299004649	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
176299004650	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
176299004651	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
176299004652	HPP family; Region: HPP; pfam04982
176299004653	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
176299004654	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
176299004655	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
176299004656	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
176299004657	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
176299004658	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
176299004659	dimer interface [polypeptide binding]; other site
176299004660	ssDNA binding site [nucleotide binding]; other site
176299004661	tetramer (dimer of dimers) interface [polypeptide binding]; other site
176299004662	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
176299004663	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
176299004664	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
176299004665	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
176299004666	Uncharacterized conserved protein [Function unknown]; Region: COG1801
176299004667	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
176299004668	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
176299004669	FMN binding site [chemical binding]; other site
176299004670	active site
176299004671	catalytic residues [active]
176299004672	substrate binding site [chemical binding]; other site
176299004673	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
176299004674	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
176299004675	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
176299004676	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
176299004677	trimer interface [polypeptide binding]; other site
176299004678	putative metal binding site [ion binding]; other site
176299004679	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
176299004680	metal binding site 2 [ion binding]; metal-binding site
176299004681	putative DNA binding helix; other site
176299004682	metal binding site 1 [ion binding]; metal-binding site
176299004683	dimer interface [polypeptide binding]; other site
176299004684	structural Zn2+ binding site [ion binding]; other site
176299004685	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299004686	ABC-ATPase subunit  interface; other site
176299004687	dimer interface [polypeptide binding]; other site
176299004688	putative PBP binding regions; other site
176299004689	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
176299004690	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299004691	Walker A/P-loop; other site
176299004692	ATP binding site [chemical binding]; other site
176299004693	Q-loop/lid; other site
176299004694	ABC transporter signature motif; other site
176299004695	Walker B; other site
176299004696	D-loop; other site
176299004697	H-loop/switch region; other site
176299004698	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
176299004699	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
176299004700	metal binding site [ion binding]; metal-binding site
176299004701	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299004702	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299004703	DNA binding site [nucleotide binding]
176299004704	domain linker motif; other site
176299004705	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
176299004706	ligand binding site [chemical binding]; other site
176299004707	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
176299004708	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
176299004709	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
176299004710	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299004711	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299004712	active site
176299004713	catalytic tetrad [active]
176299004714	Predicted integral membrane protein [Function unknown]; Region: COG5455
176299004715	6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362
176299004716	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
176299004717	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
176299004718	cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847
176299004719	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
176299004720	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
176299004721	metal-binding site [ion binding]
176299004722	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
176299004723	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
176299004724	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
176299004725	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
176299004726	4Fe-4S binding domain; Region: Fer4_5; pfam12801
176299004727	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
176299004728	IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614
176299004729	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
176299004730	hydrophobic ligand binding site; other site
176299004731	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
176299004732	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
176299004733	dimer interface [polypeptide binding]; other site
176299004734	metal binding site [ion binding]; metal-binding site
176299004735	N-terminal domain of cytochrome oxidase-cbb3, FixP; Region: FixP_N; pfam14715
176299004736	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
176299004737	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
176299004738	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
176299004739	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
176299004740	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
176299004741	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
176299004742	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
176299004743	Low-spin heme binding site [chemical binding]; other site
176299004744	Putative water exit pathway; other site
176299004745	Binuclear center (active site) [active]
176299004746	Putative proton exit pathway; other site
176299004747	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
176299004748	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
176299004749	Sulfate transporter family; Region: Sulfate_transp; cl19250
176299004750	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
176299004751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4318
176299004752	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
176299004753	Mechanosensitive ion channel; Region: MS_channel; pfam00924
176299004754	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
176299004755	homotrimer interface [polypeptide binding]; other site
176299004756	Walker A motif; other site
176299004757	GTP binding site [chemical binding]; other site
176299004758	Walker B motif; other site
176299004759	Predicted membrane protein [Function unknown]; Region: COG3821
176299004760	Predicted membrane protein [Function unknown]; Region: COG3503
176299004761	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
176299004762	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
176299004763	DNA binding residues [nucleotide binding]
176299004764	putative dimer interface [polypeptide binding]; other site
176299004765	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
176299004766	MgtE intracellular N domain; Region: MgtE_N; pfam03448
176299004767	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
176299004768	Divalent cation transporter; Region: MgtE; cl00786
176299004769	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
176299004770	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
176299004771	putative molybdopterin cofactor binding site [chemical binding]; other site
176299004772	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
176299004773	putative molybdopterin cofactor binding site; other site
176299004774	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
176299004775	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
176299004776	active site
176299004777	catalytic residues [active]
176299004778	metal binding site [ion binding]; metal-binding site
176299004779	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
176299004780	PAS fold; Region: PAS_3; pfam08447
176299004781	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299004782	heme pocket [chemical binding]; other site
176299004783	putative active site [active]
176299004784	lipoate-protein ligase B; Provisional; Region: PRK14341
176299004785	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
176299004786	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
176299004787	putative NAD(P) binding site [chemical binding]; other site
176299004788	putative substrate binding site [chemical binding]; other site
176299004789	catalytic Zn binding site [ion binding]; other site
176299004790	structural Zn binding site [ion binding]; other site
176299004791	dimer interface [polypeptide binding]; other site
176299004792	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299004793	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
176299004794	substrate binding pocket [chemical binding]; other site
176299004795	substrate-Mg2+ binding site; other site
176299004796	aspartate-rich region 1; other site
176299004797	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
176299004798	bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726
176299004799	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
176299004800	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
176299004801	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
176299004802	Protein export membrane protein; Region: SecD_SecF; pfam02355
176299004803	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
176299004804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299004805	Walker A motif; other site
176299004806	ATP binding site [chemical binding]; other site
176299004807	Walker B motif; other site
176299004808	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
176299004809	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
176299004810	trimer interface [polypeptide binding]; other site
176299004811	active site
176299004812	substrate binding site [chemical binding]; other site
176299004813	CoA binding site [chemical binding]; other site
176299004814	formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819
176299004815	Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282
176299004816	NAD binding site [chemical binding]; other site
176299004817	catalytic Zn binding site [ion binding]; other site
176299004818	structural Zn binding site [ion binding]; other site
176299004819	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299004820	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299004821	Bacterial transcriptional repressor; Region: TetR; pfam13972
176299004822	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
176299004823	Protein of unknown function (DUF3126); Region: DUF3126; pfam11324
176299004824	serine acetyltransferase; Provisional; Region: cysE; PRK11132
176299004825	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
176299004826	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
176299004827	trimer interface [polypeptide binding]; other site
176299004828	active site
176299004829	substrate binding site [chemical binding]; other site
176299004830	CoA binding site [chemical binding]; other site
176299004831	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299004832	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299004833	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391
176299004834	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
176299004835	Squalene epoxidase; Region: SE; cl17314
176299004836	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
176299004837	homodimer interface [polypeptide binding]; other site
176299004838	substrate-cofactor binding pocket; other site
176299004839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299004840	catalytic residue [active]
176299004841	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
176299004842	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299004843	substrate binding pocket [chemical binding]; other site
176299004844	membrane-bound complex binding site; other site
176299004845	hinge residues; other site
176299004846	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
176299004847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
176299004848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004849	dimer interface [polypeptide binding]; other site
176299004850	conserved gate region; other site
176299004851	putative PBP binding loops; other site
176299004852	ABC-ATPase subunit interface; other site
176299004853	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299004854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299004855	dimer interface [polypeptide binding]; other site
176299004856	conserved gate region; other site
176299004857	putative PBP binding loops; other site
176299004858	ABC-ATPase subunit interface; other site
176299004859	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299004860	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299004861	Walker A/P-loop; other site
176299004862	ATP binding site [chemical binding]; other site
176299004863	Q-loop/lid; other site
176299004864	ABC transporter signature motif; other site
176299004865	Walker B; other site
176299004866	D-loop; other site
176299004867	H-loop/switch region; other site
176299004868	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
176299004869	DHH family; Region: DHH; pfam01368
176299004870	DHHA1 domain; Region: DHHA1; pfam02272
176299004871	homoserine dehydrogenase; Provisional; Region: PRK06349
176299004872	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
176299004873	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
176299004874	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
176299004875	aminotransferase; Validated; Region: PRK09148
176299004876	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299004877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299004878	homodimer interface [polypeptide binding]; other site
176299004879	catalytic residue [active]
176299004880	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
176299004881	active site
176299004882	hypothetical protein; Provisional; Region: PRK10621
176299004883	PAS fold; Region: PAS_4; pfam08448
176299004884	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
176299004885	putative acyl-acceptor binding pocket; other site
176299004886	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
176299004887	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH_like1; cd08266
176299004888	putative NAD(P) binding site [chemical binding]; other site
176299004889	structural Zn binding site [ion binding]; other site
176299004890	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501
176299004891	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
176299004892	dimer interface [polypeptide binding]; other site
176299004893	active site
176299004894	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519
176299004895	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
176299004896	active site
176299004897	3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764
176299004898	active site 2 [active]
176299004899	active site 1 [active]
176299004900	acyl carrier protein; Provisional; Region: PRK06508
176299004901	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
176299004902	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299004903	FeS/SAM binding site; other site
176299004904	HemN C-terminal domain; Region: HemN_C; pfam06969
176299004905	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299004906	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299004907	ligand binding site [chemical binding]; other site
176299004908	flexible hinge region; other site
176299004909	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
176299004910	putative switch regulator; other site
176299004911	non-specific DNA interactions [nucleotide binding]; other site
176299004912	DNA binding site [nucleotide binding]
176299004913	sequence specific DNA binding site [nucleotide binding]; other site
176299004914	putative cAMP binding site [chemical binding]; other site
176299004915	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
176299004916	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
176299004917	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
176299004918	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
176299004919	active site
176299004920	hypothetical protein; Reviewed; Region: PRK00024
176299004921	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
176299004922	MPN+ (JAMM) motif; other site
176299004923	Zinc-binding site [ion binding]; other site
176299004924	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
176299004925	TadE-like protein; Region: TadE; pfam07811
176299004926	Predicted membrane protein [Function unknown]; Region: COG4655
176299004927	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
176299004928	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG3200
176299004929	glutathione reductase; Validated; Region: PRK06116
176299004930	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299004931	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
176299004932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184
176299004933	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
176299004934	tetramer (dimer of dimers) interface [polypeptide binding]; other site
176299004935	active site
176299004936	dimer interface [polypeptide binding]; other site
176299004937	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
176299004938	phosphoglycolate phosphatase; Provisional; Region: PRK13222
176299004939	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299004940	motif II; other site
176299004941	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
176299004942	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299004943	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299004944	fumarate hydratase; Reviewed; Region: fumC; PRK00485
176299004945	Class II fumarases; Region: Fumarase_classII; cd01362
176299004946	active site
176299004947	tetramer interface [polypeptide binding]; other site
176299004948	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
176299004949	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299004950	CTP synthetase; Validated; Region: pyrG; PRK05380
176299004951	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
176299004952	Catalytic site [active]
176299004953	active site
176299004954	UTP binding site [chemical binding]; other site
176299004955	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
176299004956	active site
176299004957	putative oxyanion hole; other site
176299004958	catalytic triad [active]
176299004959	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
176299004960	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
176299004961	substrate binding site [chemical binding]; other site
176299004962	dimer interface [polypeptide binding]; other site
176299004963	catalytic triad [active]
176299004964	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
176299004965	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
176299004966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299004967	ATP binding site [chemical binding]; other site
176299004968	Mg2+ binding site [ion binding]; other site
176299004969	G-X-G motif; other site
176299004970	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
176299004971	anchoring element; other site
176299004972	dimer interface [polypeptide binding]; other site
176299004973	ATP binding site [chemical binding]; other site
176299004974	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
176299004975	active site
176299004976	metal binding site [ion binding]; metal-binding site
176299004977	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
176299004978	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
176299004979	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299004980	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299004981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299004982	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
176299004983	Methyltransferase domain; Region: Methyltransf_31; pfam13847
176299004984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299004985	S-adenosylmethionine binding site [chemical binding]; other site
176299004986	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299004987	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299004988	NAD(P) binding site [chemical binding]; other site
176299004989	active site
176299004990	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
176299004991	oligomer interface [polypeptide binding]; other site
176299004992	active site residues [active]
176299004993	Uncharacterized conserved protein [Function unknown]; Region: COG3832
176299004994	hydrophobic ligand binding site; other site
176299004995	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299004996	dimerization interface [polypeptide binding]; other site
176299004997	putative DNA binding site [nucleotide binding]; other site
176299004998	putative Zn2+ binding site [ion binding]; other site
176299004999	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
176299005000	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
176299005001	putative active site [active]
176299005002	catalytic site [active]
176299005003	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
176299005004	putative active site [active]
176299005005	catalytic site [active]
176299005006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
176299005007	active site
176299005008	phosphorylation site [posttranslational modification]
176299005009	intermolecular recognition site; other site
176299005010	dimerization interface [polypeptide binding]; other site
176299005011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299005012	active site
176299005013	phosphorylation site [posttranslational modification]
176299005014	intermolecular recognition site; other site
176299005015	dimerization interface [polypeptide binding]; other site
176299005016	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299005017	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299005018	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
176299005019	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
176299005020	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
176299005021	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
176299005022	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
176299005023	Mechanosensitive ion channel; Region: MS_channel; pfam00924
176299005024	Predicted membrane protein [Function unknown]; Region: COG2261
176299005025	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; cl10048
176299005026	Predicted membrane protein [Function unknown]; Region: COG4125
176299005027	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
176299005028	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
176299005029	ABC-type uncharacterized transport system, auxiliary component [General function prediction only]; Region: COG3218
176299005030	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
176299005031	mce related protein; Region: MCE; pfam02470
176299005032	Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642
176299005033	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
176299005034	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
176299005035	Walker A/P-loop; other site
176299005036	ATP binding site [chemical binding]; other site
176299005037	Q-loop/lid; other site
176299005038	ABC transporter signature motif; other site
176299005039	Walker B; other site
176299005040	D-loop; other site
176299005041	H-loop/switch region; other site
176299005042	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
176299005043	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
176299005044	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
176299005045	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
176299005046	active site
176299005047	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
176299005048	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
176299005049	putative active site [active]
176299005050	putative metal binding site [ion binding]; other site
176299005051	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
176299005052	malic enzyme; Reviewed; Region: PRK12862
176299005053	Malic enzyme, N-terminal domain; Region: malic; pfam00390
176299005054	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
176299005055	putative NAD(P) binding site [chemical binding]; other site
176299005056	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
176299005057	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
176299005058	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
176299005059	putative FMN binding site [chemical binding]; other site
176299005060	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
176299005061	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
176299005062	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
176299005063	NAD synthetase; Provisional; Region: PRK13981
176299005064	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
176299005065	multimer interface [polypeptide binding]; other site
176299005066	active site
176299005067	catalytic triad [active]
176299005068	protein interface 1 [polypeptide binding]; other site
176299005069	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
176299005070	homodimer interface [polypeptide binding]; other site
176299005071	NAD binding pocket [chemical binding]; other site
176299005072	ATP binding pocket [chemical binding]; other site
176299005073	Mg binding site [ion binding]; other site
176299005074	active-site loop [active]
176299005075	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
176299005076	Sulfatase; Region: Sulfatase; pfam00884
176299005077	Predicted membrane protein [Function unknown]; Region: COG4420
176299005078	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
176299005079	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299005080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299005081	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
176299005082	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
176299005083	active site
176299005084	catalytic triad [active]
176299005085	dimer interface [polypeptide binding]; other site
176299005086	trigger factor; Provisional; Region: tig; PRK01490
176299005087	Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
176299005088	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
176299005089	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
176299005090	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
176299005091	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
176299005092	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
176299005093	Glucose inhibited division protein A; Region: GIDA; pfam01134
176299005094	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
176299005095	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
176299005096	substrate binding site [chemical binding]; other site
176299005097	catalytic Zn binding site [ion binding]; other site
176299005098	NAD binding site [chemical binding]; other site
176299005099	structural Zn binding site [ion binding]; other site
176299005100	dimer interface [polypeptide binding]; other site
176299005101	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
176299005102	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
176299005103	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
176299005104	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
176299005105	acyl-activating enzyme (AAE) consensus motif; other site
176299005106	acyl-activating enzyme (AAE) consensus motif; other site
176299005107	putative AMP binding site [chemical binding]; other site
176299005108	putative active site [active]
176299005109	putative CoA binding site [chemical binding]; other site
176299005110	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
176299005111	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
176299005112	dimer interface [polypeptide binding]; other site
176299005113	active site
176299005114	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299005115	catalytic residues [active]
176299005116	substrate binding site [chemical binding]; other site
176299005117	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
176299005118	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299005119	DNA binding residues [nucleotide binding]
176299005120	dimerization interface [polypeptide binding]; other site
176299005121	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
176299005122	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
176299005123	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
176299005124	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
176299005125	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
176299005126	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
176299005127	active site
176299005128	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
176299005129	active site
176299005130	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
176299005131	active site
176299005132	(T/H)XGH motif; other site
176299005133	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
176299005134	SurA N-terminal domain; Region: SurA_N_3; cl07813
176299005135	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
176299005136	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
176299005137	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
176299005138	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
176299005139	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
176299005140	active site
176299005141	ribulose/triose binding site [chemical binding]; other site
176299005142	phosphate binding site [ion binding]; other site
176299005143	substrate (anthranilate) binding pocket [chemical binding]; other site
176299005144	product (indole) binding pocket [chemical binding]; other site
176299005145	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
176299005146	trimer interface [polypeptide binding]; other site
176299005147	dimer interface [polypeptide binding]; other site
176299005148	putative active site [active]
176299005149	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
176299005150	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
176299005151	dimer interface [polypeptide binding]; other site
176299005152	putative functional site; other site
176299005153	putative MPT binding site; other site
176299005154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299005155	metal binding site [ion binding]; metal-binding site
176299005156	active site
176299005157	I-site; other site
176299005158	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
176299005159	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
176299005160	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
176299005161	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
176299005162	TrkA-N domain; Region: TrkA_N; pfam02254
176299005163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
176299005164	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
176299005165	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299005166	FeS/SAM binding site; other site
176299005167	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
176299005168	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299005169	EamA-like transporter family; Region: EamA; pfam00892
176299005170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299005171	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
176299005172	putative substrate translocation pore; other site
176299005173	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
176299005174	GTP binding site; other site
176299005175	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
176299005176	Walker A motif; other site
176299005177	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
176299005178	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
176299005179	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
176299005180	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
176299005181	Peptidase family M23; Region: Peptidase_M23; pfam01551
176299005182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299005183	S-adenosylmethionine binding site [chemical binding]; other site
176299005184	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
176299005185	seryl-tRNA synthetase; Provisional; Region: PRK05431
176299005186	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
176299005187	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
176299005188	dimer interface [polypeptide binding]; other site
176299005189	active site
176299005190	motif 1; other site
176299005191	motif 2; other site
176299005192	motif 3; other site
176299005193	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
176299005194	sec-independent translocase; Provisional; Region: PRK00708
176299005195	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
176299005196	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
176299005197	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
176299005198	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
176299005199	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
176299005200	Sporulation related domain; Region: SPOR; pfam05036
176299005201	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
176299005202	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
176299005203	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
176299005204	active site
176299005205	HIGH motif; other site
176299005206	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
176299005207	KMSK motif region; other site
176299005208	tRNA binding surface [nucleotide binding]; other site
176299005209	DALR anticodon binding domain; Region: DALR_1; smart00836
176299005210	anticodon binding site; other site
176299005211	dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232
176299005212	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
176299005213	Zn2+ binding site [ion binding]; other site
176299005214	Mg2+ binding site [ion binding]; other site
176299005215	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
176299005216	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
176299005217	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
176299005218	putative catalytic site [active]
176299005219	putative phosphate binding site [ion binding]; other site
176299005220	active site
176299005221	metal binding site A [ion binding]; metal-binding site
176299005222	DNA binding site [nucleotide binding]
176299005223	putative AP binding site [nucleotide binding]; other site
176299005224	putative metal binding site B [ion binding]; other site
176299005225	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
176299005226	Sel1-like repeats; Region: SEL1; smart00671
176299005227	Sel1-like repeats; Region: SEL1; smart00671
176299005228	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
176299005229	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
176299005230	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
176299005231	active site
176299005232	HIGH motif; other site
176299005233	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
176299005234	KMSKS motif; other site
176299005235	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
176299005236	tRNA binding surface [nucleotide binding]; other site
176299005237	anticodon binding site; other site
176299005238	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
176299005239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3827
176299005240	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
176299005241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299005242	S-adenosylmethionine binding site [chemical binding]; other site
176299005243	rare lipoprotein A; Provisional; Region: PRK10672
176299005244	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
176299005245	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
176299005246	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
176299005247	putative MPT binding site; other site
176299005248	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
176299005249	Ligand Binding Site [chemical binding]; other site
176299005250	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299005251	active site
176299005252	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
176299005253	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
176299005254	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
176299005255	active site
176299005256	dimer interface [polypeptide binding]; other site
176299005257	effector binding site; other site
176299005258	Transcriptional regulator; Region: Transcrip_reg; cl00361
176299005259	TSCPD domain; Region: TSCPD; pfam12637
176299005260	Predicted transcriptional regulator [Transcription]; Region: COG2944
176299005261	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299005262	non-specific DNA binding site [nucleotide binding]; other site
176299005263	salt bridge; other site
176299005264	sequence-specific DNA binding site [nucleotide binding]; other site
176299005265	manganese transport protein MntH; Reviewed; Region: PRK00701
176299005266	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
176299005267	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
176299005268	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299005269	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
176299005270	Walker A/P-loop; other site
176299005271	ATP binding site [chemical binding]; other site
176299005272	Q-loop/lid; other site
176299005273	ABC transporter signature motif; other site
176299005274	Walker B; other site
176299005275	D-loop; other site
176299005276	H-loop/switch region; other site
176299005277	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
176299005278	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299005279	Coenzyme A binding pocket [chemical binding]; other site
176299005280	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5330
176299005281	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
176299005282	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
176299005283	putative FMN binding site [chemical binding]; other site
176299005284	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
176299005285	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
176299005286	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
176299005287	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
176299005288	active site
176299005289	dimer interface [polypeptide binding]; other site
176299005290	motif 1; other site
176299005291	motif 2; other site
176299005292	motif 3; other site
176299005293	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
176299005294	anticodon binding site; other site
176299005295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
176299005296	hypothetical protein; Validated; Region: PRK00041
176299005297	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
176299005298	trimerization site [polypeptide binding]; other site
176299005299	active site
176299005300	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
176299005301	active site
176299005302	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
176299005303	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
176299005304	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
176299005305	active site
176299005306	nucleophile elbow; other site
176299005307	FOG: CBS domain [General function prediction only]; Region: COG0517
176299005308	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
176299005309	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
176299005310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
176299005311	PilZ domain; Region: PilZ; pfam07238
176299005312	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: Peptidase_C93; pfam06035
176299005313	Uncharacterized conserved protein [Function unknown]; Region: COG5458
176299005314	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
176299005315	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
176299005316	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
176299005317	Predicted periplasmic protein [Function unknown]; Region: COG3698
176299005318	Entericidin EcnA/B family; Region: Entericidin; pfam08085
176299005319	Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653
176299005320	putative active site [active]
176299005321	putative substrate binding site [chemical binding]; other site
176299005322	putative cosubstrate binding site; other site
176299005323	catalytic site [active]
176299005324	5,10-methylenetetrahydrofolate reductase [Amino acid transport and metabolism]; Region: MetF; COG0685
176299005325	FAD binding site [chemical binding]; other site
176299005326	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299005327	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299005328	dimerization interface [polypeptide binding]; other site
176299005329	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
176299005330	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
176299005331	conserved cys residue [active]
176299005332	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299005333	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299005334	Uncharacterized conserved protein [Function unknown]; Region: COG0062
176299005335	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
176299005336	putative substrate binding site [chemical binding]; other site
176299005337	putative ATP binding site [chemical binding]; other site
176299005338	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
176299005339	glutamine synthetase; Provisional; Region: glnA; PRK09469
176299005340	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
176299005341	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
176299005342	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299005343	EamA-like transporter family; Region: EamA; pfam00892
176299005344	EamA-like transporter family; Region: EamA; pfam00892
176299005345	Uncharacterized conserved protein [Function unknown]; Region: COG3785
176299005346	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
176299005347	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
176299005348	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
176299005349	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
176299005350	catalytic residues [active]
176299005351	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299005352	EamA-like transporter family; Region: EamA; pfam00892
176299005353	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
176299005354	Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
176299005355	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
176299005356	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299005357	ATP binding site [chemical binding]; other site
176299005358	putative Mg++ binding site [ion binding]; other site
176299005359	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299005360	nucleotide binding region [chemical binding]; other site
176299005361	ATP-binding site [chemical binding]; other site
176299005362	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
176299005363	Uncharacterized conserved protein [Function unknown]; Region: COG2938
176299005364	RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200
176299005365	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
176299005366	generic binding surface II; other site
176299005367	ssDNA binding site; other site
176299005368	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299005369	ATP binding site [chemical binding]; other site
176299005370	putative Mg++ binding site [ion binding]; other site
176299005371	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299005372	nucleotide binding region [chemical binding]; other site
176299005373	ATP-binding site [chemical binding]; other site
176299005374	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
176299005375	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
176299005376	Predicted transcriptional regulator [Transcription]; Region: COG3905
176299005377	Uncharacterized conserved protein [Function unknown]; Region: COG2928
176299005378	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299005379	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299005380	Coenzyme A binding pocket [chemical binding]; other site
176299005381	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
176299005382	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
176299005383	glutaminase active site [active]
176299005384	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
176299005385	dimer interface [polypeptide binding]; other site
176299005386	active site
176299005387	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
176299005388	dimer interface [polypeptide binding]; other site
176299005389	active site
176299005390	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
176299005391	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
176299005392	Substrate binding site; other site
176299005393	Mg++ binding site; other site
176299005394	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
176299005395	active site
176299005396	substrate binding site [chemical binding]; other site
176299005397	CoA binding site [chemical binding]; other site
176299005398	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299005399	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299005400	DNA-binding site [nucleotide binding]; DNA binding site
176299005401	FCD domain; Region: FCD; pfam07729
176299005402	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
176299005403	putative ligand binding site [chemical binding]; other site
176299005404	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
176299005405	TM-ABC transporter signature motif; other site
176299005406	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
176299005407	TM-ABC transporter signature motif; other site
176299005408	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
176299005409	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299005410	Walker A/P-loop; other site
176299005411	ATP binding site [chemical binding]; other site
176299005412	Q-loop/lid; other site
176299005413	ABC transporter signature motif; other site
176299005414	Walker B; other site
176299005415	D-loop; other site
176299005416	H-loop/switch region; other site
176299005417	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299005418	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
176299005419	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
176299005420	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
176299005421	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
176299005422	Predicted permeases [General function prediction only]; Region: COG0679
176299005423	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
176299005424	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
176299005425	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
176299005426	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
176299005427	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
176299005428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
176299005429	Peptidase M15; Region: Peptidase_M15_3; cl01194
176299005430	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
176299005431	dimer interface [polypeptide binding]; other site
176299005432	active site
176299005433	metal binding site [ion binding]; metal-binding site
176299005434	glutathione binding site [chemical binding]; other site
176299005435	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
176299005436	DNA-binding site [nucleotide binding]; DNA binding site
176299005437	RNA-binding motif; other site
176299005438	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
176299005439	DNA-binding site [nucleotide binding]; DNA binding site
176299005440	RNA-binding motif; other site
176299005441	Uncharacterized conserved protein [Function unknown]; Region: COG1430
176299005442	BON domain; Region: BON; pfam04972
176299005443	Protein of unknown function (DUF982); Region: DUF982; pfam06169
176299005444	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
176299005445	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
176299005446	ligand binding site; other site
176299005447	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
176299005448	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299005449	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299005450	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299005451	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299005452	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
176299005453	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299005454	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299005455	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299005456	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299005457	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
176299005458	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
176299005459	Walker A/P-loop; other site
176299005460	ATP binding site [chemical binding]; other site
176299005461	Q-loop/lid; other site
176299005462	ABC transporter signature motif; other site
176299005463	Walker B; other site
176299005464	D-loop; other site
176299005465	H-loop/switch region; other site
176299005466	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
176299005467	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
176299005468	FtsX-like permease family; Region: FtsX; pfam02687
176299005469	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
176299005470	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
176299005471	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
176299005472	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
176299005473	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299005474	catalytic residue [active]
176299005475	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
176299005476	FeS assembly protein SufD; Region: sufD; TIGR01981
176299005477	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
176299005478	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
176299005479	Walker A/P-loop; other site
176299005480	ATP binding site [chemical binding]; other site
176299005481	Q-loop/lid; other site
176299005482	ABC transporter signature motif; other site
176299005483	Walker B; other site
176299005484	D-loop; other site
176299005485	H-loop/switch region; other site
176299005486	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
176299005487	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
176299005488	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
176299005489	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299005490	catalytic residue [active]
176299005491	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
176299005492	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases [Posttranslational modification, protein turnover, chaperones]; Region: COG2377
176299005493	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
176299005494	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
176299005495	active site
176299005496	HIGH motif; other site
176299005497	dimer interface [polypeptide binding]; other site
176299005498	KMSKS motif; other site
176299005499	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
176299005500	RNA binding surface [nucleotide binding]; other site
176299005501	Protein of unknown function; Region: DUF3971; pfam13116
176299005502	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
176299005503	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
176299005504	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
176299005505	catalytic triad [active]
176299005506	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
176299005507	dinuclear metal binding motif [ion binding]; other site
176299005508	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
176299005509	Peptidase family M23; Region: Peptidase_M23; pfam01551
176299005510	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
176299005511	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
176299005512	ATP binding site [chemical binding]; other site
176299005513	Mg++ binding site [ion binding]; other site
176299005514	motif III; other site
176299005515	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299005516	nucleotide binding region [chemical binding]; other site
176299005517	ATP-binding site [chemical binding]; other site
176299005518	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
176299005519	nudix motif; other site
176299005520	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299005521	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299005522	non-specific DNA binding site [nucleotide binding]; other site
176299005523	salt bridge; other site
176299005524	sequence-specific DNA binding site [nucleotide binding]; other site
176299005525	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
176299005526	ligand binding site [chemical binding]; other site
176299005527	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
176299005528	substrate binding site [chemical binding]; other site
176299005529	hexamer interface [polypeptide binding]; other site
176299005530	metal binding site [ion binding]; metal-binding site
176299005531	adenylosuccinate lyase; Provisional; Region: PRK07492
176299005532	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
176299005533	tetramer interface [polypeptide binding]; other site
176299005534	active site
176299005535	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
176299005536	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299005537	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
176299005538	ATP binding site [chemical binding]; other site
176299005539	active site
176299005540	substrate binding site [chemical binding]; other site
176299005541	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
176299005542	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
176299005543	putative active site [active]
176299005544	catalytic triad [active]
176299005545	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
176299005546	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
176299005547	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299005548	DNA-binding site [nucleotide binding]; DNA binding site
176299005549	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299005550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299005551	homodimer interface [polypeptide binding]; other site
176299005552	catalytic residue [active]
176299005553	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
176299005554	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
176299005555	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
176299005556	dimerization interface [polypeptide binding]; other site
176299005557	ATP binding site [chemical binding]; other site
176299005558	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
176299005559	dimerization interface [polypeptide binding]; other site
176299005560	ATP binding site [chemical binding]; other site
176299005561	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
176299005562	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
176299005563	putative GSH binding site [chemical binding]; other site
176299005564	catalytic residues [active]
176299005565	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
176299005566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299005567	putative substrate translocation pore; other site
176299005568	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
176299005569	active site
176299005570	putative lithium-binding site [ion binding]; other site
176299005571	substrate binding site [chemical binding]; other site
176299005572	PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517
176299005573	active site
176299005574	putative lithium-binding site [ion binding]; other site
176299005575	substrate binding site [chemical binding]; other site
176299005576	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
176299005577	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
176299005578	Ligand Binding Site [chemical binding]; other site
176299005579	TIGR00269 family protein; Region: TIGR00269
176299005580	glutaminase; Provisional; Region: PRK00971
176299005581	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
176299005582	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
176299005583	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
176299005584	RNA binding surface [nucleotide binding]; other site
176299005585	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
176299005586	Domain of unknown function DUF87; Region: DUF87; cl19135
176299005587	HerA helicase [Replication, recombination, and repair]; Region: COG0433
176299005588	AAA ATPase domain; Region: AAA_16; pfam13191
176299005589	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
176299005590	EamA-like transporter family; Region: EamA; pfam00892
176299005591	EamA-like transporter family; Region: EamA; pfam00892
176299005592	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299005593	glutamate racemase; Provisional; Region: PRK00865
176299005594	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
176299005595	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
176299005596	isocitrate dehydrogenase; Validated; Region: PRK08299
176299005597	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299005598	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
176299005599	putative C-terminal domain interface [polypeptide binding]; other site
176299005600	putative GSH binding site (G-site) [chemical binding]; other site
176299005601	putative dimer interface [polypeptide binding]; other site
176299005602	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
176299005603	dimer interface [polypeptide binding]; other site
176299005604	N-terminal domain interface [polypeptide binding]; other site
176299005605	putative substrate binding pocket (H-site) [chemical binding]; other site
176299005606	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_23; cd09011
176299005607	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
176299005608	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
176299005609	motif 1; other site
176299005610	active site
176299005611	motif 2; other site
176299005612	motif 3; other site
176299005613	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
176299005614	recombinase A; Provisional; Region: recA; PRK09354
176299005615	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
176299005616	hexamer interface [polypeptide binding]; other site
176299005617	Walker A motif; other site
176299005618	ATP binding site [chemical binding]; other site
176299005619	Walker B motif; other site
176299005620	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
176299005621	substrate binding site [chemical binding]; other site
176299005622	ATP binding site [chemical binding]; other site
176299005623	Uncharacterized enzyme involved in pigment biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IndA; COG2313
176299005624	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
176299005625	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
176299005626	ligand binding site [chemical binding]; other site
176299005627	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
176299005628	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299005629	substrate binding pocket [chemical binding]; other site
176299005630	membrane-bound complex binding site; other site
176299005631	hinge residues; other site
176299005632	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
176299005633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299005634	dimer interface [polypeptide binding]; other site
176299005635	conserved gate region; other site
176299005636	putative PBP binding loops; other site
176299005637	ABC-ATPase subunit interface; other site
176299005638	ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160
176299005639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299005640	dimer interface [polypeptide binding]; other site
176299005641	conserved gate region; other site
176299005642	putative PBP binding loops; other site
176299005643	ABC-ATPase subunit interface; other site
176299005644	Usg protein, probable subunit of phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Region: COG5425
176299005645	Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976
176299005646	Tetratricopeptide repeat; Region: TPR_1; pfam00515
176299005647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
176299005648	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299005649	S-adenosylmethionine binding site [chemical binding]; other site
176299005650	NMT1-like family; Region: NMT1_2; cl17432
176299005651	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
176299005652	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299005653	substrate binding pocket [chemical binding]; other site
176299005654	membrane-bound complex binding site; other site
176299005655	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299005656	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299005657	putative DNA binding site [nucleotide binding]; other site
176299005658	putative Zn2+ binding site [ion binding]; other site
176299005659	AsnC family; Region: AsnC_trans_reg; pfam01037
176299005660	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
176299005661	putative uracil binding site [chemical binding]; other site
176299005662	putative active site [active]
176299005663	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
176299005664	Staphylococcal nuclease homologue; Region: SNase; cl00140
176299005665	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299005666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299005667	dimer interface [polypeptide binding]; other site
176299005668	phosphorylation site [posttranslational modification]
176299005669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299005670	ATP binding site [chemical binding]; other site
176299005671	Mg2+ binding site [ion binding]; other site
176299005672	G-X-G motif; other site
176299005673	Integral membrane diacylglycerol kinase; Region: DAGK_IM; cd14264
176299005674	putative active site [active]
176299005675	trimer interface [polypeptide binding]; other site
176299005676	putative active site [active]
176299005677	Zn binding site [ion binding]; other site
176299005678	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
176299005679	putative dimer interface [polypeptide binding]; other site
176299005680	active site pocket [active]
176299005681	putative cataytic base [active]
176299005682	cobalamin synthase; Reviewed; Region: cobS; PRK00235
176299005683	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
176299005684	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
176299005685	catalytic motif [active]
176299005686	Catalytic residue [active]
176299005687	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
176299005688	short chain dehydrogenase; Provisional; Region: PRK06114
176299005689	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299005690	NAD(P) binding site [chemical binding]; other site
176299005691	active site
176299005692	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299005693	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299005694	Walker A/P-loop; other site
176299005695	ATP binding site [chemical binding]; other site
176299005696	Q-loop/lid; other site
176299005697	ABC transporter signature motif; other site
176299005698	Walker B; other site
176299005699	D-loop; other site
176299005700	H-loop/switch region; other site
176299005701	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299005702	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
176299005703	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299005704	ligand binding site [chemical binding]; other site
176299005705	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299005706	TM-ABC transporter signature motif; other site
176299005707	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
176299005708	TPP-binding site [chemical binding]; other site
176299005709	dimer interface [polypeptide binding]; other site
176299005710	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
176299005711	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
176299005712	PYR/PP interface [polypeptide binding]; other site
176299005713	dimer interface [polypeptide binding]; other site
176299005714	TPP binding site [chemical binding]; other site
176299005715	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
176299005716	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
176299005717	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
176299005718	N- and C-terminal domain interface [polypeptide binding]; other site
176299005719	active site
176299005720	MgATP binding site [chemical binding]; other site
176299005721	catalytic site [active]
176299005722	metal binding site [ion binding]; metal-binding site
176299005723	putative homotetramer interface [polypeptide binding]; other site
176299005724	putative homodimer interface [polypeptide binding]; other site
176299005725	glycerol binding site [chemical binding]; other site
176299005726	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
176299005727	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
176299005728	putative DNA binding site [nucleotide binding]; other site
176299005729	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
176299005730	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299005731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299005732	NAD(P) binding site [chemical binding]; other site
176299005733	active site
176299005734	ABC-2 type transporter; Region: ABC2_membrane; cl17235
176299005735	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
176299005736	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
176299005737	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
176299005738	Walker A/P-loop; other site
176299005739	ATP binding site [chemical binding]; other site
176299005740	Q-loop/lid; other site
176299005741	ABC transporter signature motif; other site
176299005742	Walker B; other site
176299005743	D-loop; other site
176299005744	H-loop/switch region; other site
176299005745	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
176299005746	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
176299005747	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
176299005748	Cache domain; Region: Cache_2; pfam08269
176299005749	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
176299005750	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299005751	dimerization interface [polypeptide binding]; other site
176299005752	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299005753	dimer interface [polypeptide binding]; other site
176299005754	putative CheW interface [polypeptide binding]; other site
176299005755	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
176299005756	recombination factor protein RarA; Reviewed; Region: PRK13342
176299005757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299005758	Walker A motif; other site
176299005759	ATP binding site [chemical binding]; other site
176299005760	Walker B motif; other site
176299005761	arginine finger; other site
176299005762	Protein of unknown function (DUF2379); Region: DUF2379; cl15283
176299005763	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
176299005764	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
176299005765	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
176299005766	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
176299005767	protein binding site [polypeptide binding]; other site
176299005768	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
176299005769	protein binding site [polypeptide binding]; other site
176299005770	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
176299005771	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
176299005772	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
176299005773	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
176299005774	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
176299005775	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
176299005776	Moco binding site; other site
176299005777	metal coordination site [ion binding]; other site
176299005778	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
176299005779	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
176299005780	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
176299005781	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
176299005782	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
176299005783	alphaNTD homodimer interface [polypeptide binding]; other site
176299005784	alphaNTD - beta interaction site [polypeptide binding]; other site
176299005785	alphaNTD - beta' interaction site [polypeptide binding]; other site
176299005786	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
176299005787	30S ribosomal protein S11; Validated; Region: PRK05309
176299005788	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
176299005789	adenylate kinase; Reviewed; Region: adk; PRK00279
176299005790	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
176299005791	AMP-binding site [chemical binding]; other site
176299005792	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
176299005793	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
176299005794	SecY translocase; Region: SecY; pfam00344
176299005795	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
176299005796	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
176299005797	23S rRNA binding site [nucleotide binding]; other site
176299005798	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
176299005799	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
176299005800	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
176299005801	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
176299005802	23S rRNA interface [nucleotide binding]; other site
176299005803	L21e interface [polypeptide binding]; other site
176299005804	5S rRNA interface [nucleotide binding]; other site
176299005805	L27 interface [polypeptide binding]; other site
176299005806	L5 interface [polypeptide binding]; other site
176299005807	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
176299005808	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
176299005809	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
176299005810	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
176299005811	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
176299005812	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
176299005813	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
176299005814	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
176299005815	RNA binding site [nucleotide binding]; other site
176299005816	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
176299005817	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
176299005818	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
176299005819	putative translocon interaction site; other site
176299005820	23S rRNA interface [nucleotide binding]; other site
176299005821	signal recognition particle (SRP54) interaction site; other site
176299005822	L23 interface [polypeptide binding]; other site
176299005823	trigger factor interaction site; other site
176299005824	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
176299005825	23S rRNA interface [nucleotide binding]; other site
176299005826	5S rRNA interface [nucleotide binding]; other site
176299005827	putative antibiotic binding site [chemical binding]; other site
176299005828	L25 interface [polypeptide binding]; other site
176299005829	L27 interface [polypeptide binding]; other site
176299005830	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
176299005831	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
176299005832	G-X-X-G motif; other site
176299005833	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
176299005834	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
176299005835	putative translocon binding site; other site
176299005836	protein-rRNA interface [nucleotide binding]; other site
176299005837	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
176299005838	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
176299005839	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
176299005840	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
176299005841	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
176299005842	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
176299005843	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
176299005844	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
176299005845	elongation factor Tu; Reviewed; Region: PRK00049
176299005846	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
176299005847	G1 box; other site
176299005848	GEF interaction site [polypeptide binding]; other site
176299005849	GTP/Mg2+ binding site [chemical binding]; other site
176299005850	Switch I region; other site
176299005851	G2 box; other site
176299005852	G3 box; other site
176299005853	Switch II region; other site
176299005854	G4 box; other site
176299005855	G5 box; other site
176299005856	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
176299005857	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
176299005858	Antibiotic Binding Site [chemical binding]; other site
176299005859	elongation factor G; Reviewed; Region: PRK00007
176299005860	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
176299005861	G1 box; other site
176299005862	putative GEF interaction site [polypeptide binding]; other site
176299005863	GTP/Mg2+ binding site [chemical binding]; other site
176299005864	Switch I region; other site
176299005865	G2 box; other site
176299005866	G3 box; other site
176299005867	Switch II region; other site
176299005868	G4 box; other site
176299005869	G5 box; other site
176299005870	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
176299005871	Elongation Factor G, domain II; Region: EFG_II; pfam14492
176299005872	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
176299005873	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
176299005874	30S ribosomal protein S7; Validated; Region: PRK05302
176299005875	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
176299005876	S17 interaction site [polypeptide binding]; other site
176299005877	S8 interaction site; other site
176299005878	16S rRNA interaction site [nucleotide binding]; other site
176299005879	streptomycin interaction site [chemical binding]; other site
176299005880	23S rRNA interaction site [nucleotide binding]; other site
176299005881	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
176299005882	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
176299005883	dimer interface [polypeptide binding]; other site
176299005884	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
176299005885	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299005886	DNA binding residues [nucleotide binding]
176299005887	dimerization interface [polypeptide binding]; other site
176299005888	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
176299005889	Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
176299005890	beta and beta' interface [polypeptide binding]; other site
176299005891	beta' and sigma factor interface [polypeptide binding]; other site
176299005892	Zn-binding [ion binding]; other site
176299005893	active site region [active]
176299005894	catalytic site [active]
176299005895	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
176299005896	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
176299005897	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
176299005898	G-loop; other site
176299005899	DNA binding site [nucleotide binding]
176299005900	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
176299005901	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
176299005902	RPB12 interaction site [polypeptide binding]; other site
176299005903	RPB1 interaction site [polypeptide binding]; other site
176299005904	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
176299005905	RPB10 interaction site [polypeptide binding]; other site
176299005906	RPB11 interaction site [polypeptide binding]; other site
176299005907	RPB3 interaction site [polypeptide binding]; other site
176299005908	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
176299005909	core dimer interface [polypeptide binding]; other site
176299005910	peripheral dimer interface [polypeptide binding]; other site
176299005911	L10 interface [polypeptide binding]; other site
176299005912	L11 interface [polypeptide binding]; other site
176299005913	putative EF-Tu interaction site [polypeptide binding]; other site
176299005914	putative EF-G interaction site [polypeptide binding]; other site
176299005915	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
176299005916	23S rRNA interface [nucleotide binding]; other site
176299005917	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
176299005918	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
176299005919	mRNA/rRNA interface [nucleotide binding]; other site
176299005920	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
176299005921	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
176299005922	23S rRNA interface [nucleotide binding]; other site
176299005923	L7/L12 interface [polypeptide binding]; other site
176299005924	putative thiostrepton binding site; other site
176299005925	L25 interface [polypeptide binding]; other site
176299005926	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
176299005927	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
176299005928	putative homodimer interface [polypeptide binding]; other site
176299005929	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
176299005930	heterodimer interface [polypeptide binding]; other site
176299005931	homodimer interface [polypeptide binding]; other site
176299005932	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
176299005933	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299005934	extended (e) SDRs; Region: SDR_e; cd08946
176299005935	NAD(P) binding site [chemical binding]; other site
176299005936	active site
176299005937	substrate binding site [chemical binding]; other site
176299005938	elongation factor Tu; Reviewed; Region: PRK00049
176299005939	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
176299005940	G1 box; other site
176299005941	GEF interaction site [polypeptide binding]; other site
176299005942	GTP/Mg2+ binding site [chemical binding]; other site
176299005943	Switch I region; other site
176299005944	G2 box; other site
176299005945	G3 box; other site
176299005946	Switch II region; other site
176299005947	G4 box; other site
176299005948	G5 box; other site
176299005949	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
176299005950	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
176299005951	Antibiotic Binding Site [chemical binding]; other site
176299005952	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
176299005953	Predicted periplasmic protein [General function prediction only]; Region: COG3895
176299005954	BA14K-like protein; Region: BA14K; pfam07886
176299005955	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
176299005956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299005957	S-adenosylmethionine binding site [chemical binding]; other site
176299005958	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
176299005959	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
176299005960	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
176299005961	Uncharacterized conserved protein [Function unknown]; Region: COG3496
176299005962	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
176299005963	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299005964	S-adenosylmethionine binding site [chemical binding]; other site
176299005965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4731
176299005966	Predicted membrane protein [Function unknown]; Region: COG4852
176299005967	RNA polymerase sigma factor; Provisional; Region: PRK12514
176299005968	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299005969	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299005970	DNA binding residues [nucleotide binding]
176299005971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343
176299005972	Anti-sigma-K factor rskA; Region: RskA; pfam10099
176299005973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299005974	active site
176299005975	phosphorylation site [posttranslational modification]
176299005976	intermolecular recognition site; other site
176299005977	dimerization interface [polypeptide binding]; other site
176299005978	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
176299005979	Histidine kinase; Region: HisKA_2; pfam07568
176299005980	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299005981	ATP binding site [chemical binding]; other site
176299005982	Mg2+ binding site [ion binding]; other site
176299005983	G-X-G motif; other site
176299005984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299005985	active site
176299005986	phosphorylation site [posttranslational modification]
176299005987	intermolecular recognition site; other site
176299005988	dimerization interface [polypeptide binding]; other site
176299005989	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
176299005990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299005991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299005992	dimer interface [polypeptide binding]; other site
176299005993	phosphorylation site [posttranslational modification]
176299005994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299005995	ATP binding site [chemical binding]; other site
176299005996	Mg2+ binding site [ion binding]; other site
176299005997	G-X-G motif; other site
176299005998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299005999	active site
176299006000	phosphorylation site [posttranslational modification]
176299006001	intermolecular recognition site; other site
176299006002	dimerization interface [polypeptide binding]; other site
176299006003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299006004	active site
176299006005	phosphorylation site [posttranslational modification]
176299006006	intermolecular recognition site; other site
176299006007	dimerization interface [polypeptide binding]; other site
176299006008	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
176299006009	HWE histidine kinase; Region: HWE_HK; smart00911
176299006010	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299006011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299006012	active site
176299006013	phosphorylation site [posttranslational modification]
176299006014	intermolecular recognition site; other site
176299006015	dimerization interface [polypeptide binding]; other site
176299006016	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
176299006017	PAS fold; Region: PAS_2; pfam08446
176299006018	GAF domain; Region: GAF; pfam01590
176299006019	Phytochrome region; Region: PHY; pfam00360
176299006020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299006021	dimer interface [polypeptide binding]; other site
176299006022	phosphorylation site [posttranslational modification]
176299006023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299006024	ATP binding site [chemical binding]; other site
176299006025	Mg2+ binding site [ion binding]; other site
176299006026	G-X-G motif; other site
176299006027	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
176299006028	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
176299006029	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
176299006030	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
176299006031	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
176299006032	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
176299006033	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
176299006034	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
176299006035	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4922
176299006036	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
176299006037	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
176299006038	NAD binding site [chemical binding]; other site
176299006039	substrate binding site [chemical binding]; other site
176299006040	putative active site [active]
176299006041	Predicted transcriptional regulators [Transcription]; Region: COG1733
176299006042	dimerization interface [polypeptide binding]; other site
176299006043	putative DNA binding site [nucleotide binding]; other site
176299006044	putative Zn2+ binding site [ion binding]; other site
176299006045	excinuclease ABC subunit B; Provisional; Region: PRK05298
176299006046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299006047	ATP binding site [chemical binding]; other site
176299006048	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299006049	nucleotide binding region [chemical binding]; other site
176299006050	ATP-binding site [chemical binding]; other site
176299006051	Ultra-violet resistance protein B; Region: UvrB; pfam12344
176299006052	UvrB/uvrC motif; Region: UVR; pfam02151
176299006053	Predicted esterase [General function prediction only]; Region: COG0627
176299006054	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
176299006055	Uncharacterized conserved protein [Function unknown]; Region: COG5649
176299006056	PRC-barrel domain; Region: PRC; pfam05239
176299006057	Predicted secreted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5664
176299006058	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
176299006059	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
176299006060	HSP70 interaction site [polypeptide binding]; other site
176299006061	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192
176299006062	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
176299006063	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299006064	metal binding site [ion binding]; metal-binding site
176299006065	active site
176299006066	I-site; other site
176299006067	putative catalytic site [active]
176299006068	putative metal binding site [ion binding]; other site
176299006069	putative phosphate binding site [ion binding]; other site
176299006070	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
176299006071	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299006072	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
176299006073	Walker A/P-loop; other site
176299006074	ATP binding site [chemical binding]; other site
176299006075	Q-loop/lid; other site
176299006076	ABC transporter signature motif; other site
176299006077	Walker B; other site
176299006078	D-loop; other site
176299006079	H-loop/switch region; other site
176299006080	TOBE domain; Region: TOBE_2; pfam08402
176299006081	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
176299006082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299006083	dimer interface [polypeptide binding]; other site
176299006084	conserved gate region; other site
176299006085	putative PBP binding loops; other site
176299006086	ABC-ATPase subunit interface; other site
176299006087	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299006088	dimer interface [polypeptide binding]; other site
176299006089	conserved gate region; other site
176299006090	putative PBP binding loops; other site
176299006091	ABC-ATPase subunit interface; other site
176299006092	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299006093	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
176299006094	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299006095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299006096	homodimer interface [polypeptide binding]; other site
176299006097	catalytic residue [active]
176299006098	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
176299006099	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
176299006100	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
176299006101	ketol-acid reductoisomerase; Provisional; Region: PRK05479
176299006102	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
176299006103	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
176299006104	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299006105	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299006106	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
176299006107	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299006108	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299006109	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
176299006110	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
176299006111	putative NAD(P) binding site [chemical binding]; other site
176299006112	putative substrate binding site [chemical binding]; other site
176299006113	catalytic Zn binding site [ion binding]; other site
176299006114	structural Zn binding site [ion binding]; other site
176299006115	dimer interface [polypeptide binding]; other site
176299006116	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
176299006117	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299006118	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
176299006119	active site
176299006120	hydrophilic channel; other site
176299006121	dimerization interface [polypeptide binding]; other site
176299006122	catalytic residues [active]
176299006123	active site lid [active]
176299006124	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
176299006125	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
176299006126	DNA binding residues [nucleotide binding]
176299006127	dimer interface [polypeptide binding]; other site
176299006128	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
176299006129	DNA binding residues [nucleotide binding]
176299006130	dimerization interface [polypeptide binding]; other site
176299006131	ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507
176299006132	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299006133	Walker A motif; other site
176299006134	ATP binding site [chemical binding]; other site
176299006135	Walker B motif; other site
176299006136	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
176299006137	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
176299006138	putative hydrophobic ligand binding site [chemical binding]; other site
176299006139	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299006140	dimerization interface [polypeptide binding]; other site
176299006141	putative DNA binding site [nucleotide binding]; other site
176299006142	putative Zn2+ binding site [ion binding]; other site
176299006143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
176299006144	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
176299006145	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
176299006146	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
176299006147	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299006148	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299006149	DNA binding residues [nucleotide binding]
176299006150	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
176299006151	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299006152	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299006153	active site
176299006154	catalytic tetrad [active]
176299006155	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
176299006156	putative hydrophobic ligand binding site [chemical binding]; other site
176299006157	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299006158	dimerization interface [polypeptide binding]; other site
176299006159	putative DNA binding site [nucleotide binding]; other site
176299006160	putative Zn2+ binding site [ion binding]; other site
176299006161	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
176299006162	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
176299006163	putative valine binding site [chemical binding]; other site
176299006164	dimer interface [polypeptide binding]; other site
176299006165	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
176299006166	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
176299006167	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
176299006168	PYR/PP interface [polypeptide binding]; other site
176299006169	dimer interface [polypeptide binding]; other site
176299006170	TPP binding site [chemical binding]; other site
176299006171	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
176299006172	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
176299006173	TPP-binding site [chemical binding]; other site
176299006174	dimer interface [polypeptide binding]; other site
176299006175	HerA helicase [Replication, recombination, and repair]; Region: COG0433
176299006176	Domain of unknown function DUF87; Region: DUF87; pfam01935
176299006177	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299006178	ATP binding site [chemical binding]; other site
176299006179	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
176299006180	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
176299006181	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
176299006182	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299006183	motif II; other site
176299006184	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299006185	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299006186	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299006187	classical (c) SDRs; Region: SDR_c; cd05233
176299006188	NAD(P) binding site [chemical binding]; other site
176299006189	active site
176299006190	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
176299006191	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
176299006192	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
176299006193	protein binding site [polypeptide binding]; other site
176299006194	PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
176299006195	protein binding site [polypeptide binding]; other site
176299006196	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
176299006197	High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405
176299006198	High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404
176299006199	HflK protein; Region: hflK; TIGR01933
176299006200	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
176299006201	folate binding site [chemical binding]; other site
176299006202	NADP+ binding site [chemical binding]; other site
176299006203	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
176299006204	dimerization interface [polypeptide binding]; other site
176299006205	active site
176299006206	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
176299006207	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3814
176299006208	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
176299006209	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
176299006210	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
176299006211	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
176299006212	FAD binding domain; Region: FAD_binding_4; pfam01565
176299006213	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
176299006214	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299006215	MMPL family; Region: MMPL; cl14618
176299006216	MMPL family; Region: MMPL; cl14618
176299006217	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299006218	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299006219	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299006220	Uncharacterized conserved protein [Function unknown]; Region: COG2128
176299006221	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
176299006222	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
176299006223	Part of AAA domain; Region: AAA_19; pfam13245
176299006224	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
176299006225	Glycosyltransferase involved in LPS biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG3306
176299006226	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
176299006227	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299006228	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
176299006229	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
176299006230	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299006231	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299006232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
176299006233	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
176299006234	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
176299006235	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
176299006236	catalytic triad [active]
176299006237	metal binding site [ion binding]; metal-binding site
176299006238	conserved cis-peptide bond; other site
176299006239	Uncharacterized conserved protein [Function unknown]; Region: COG5460
176299006240	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
176299006241	Predicted membrane protein [Function unknown]; Region: COG4541
176299006242	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299006243	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
176299006244	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299006245	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
176299006246	active site
176299006247	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
176299006248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299006249	S-adenosylmethionine binding site [chemical binding]; other site
176299006250	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
176299006251	Cu(I) binding site [ion binding]; other site
176299006252	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
176299006253	putative CheA interaction surface; other site
176299006254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
176299006255	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
176299006256	active site
176299006257	catalytic site [active]
176299006258	substrate binding site [chemical binding]; other site
176299006259	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299006260	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299006261	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
176299006262	dimerization interface [polypeptide binding]; other site
176299006263	substrate binding pocket [chemical binding]; other site
176299006264	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299006265	EamA-like transporter family; Region: EamA; pfam00892
176299006266	EamA-like transporter family; Region: EamA; pfam00892
176299006267	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299006268	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299006269	Coenzyme A binding pocket [chemical binding]; other site
176299006270	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299006271	Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155
176299006272	Phosphotransferase enzyme family; Region: APH; pfam01636
176299006273	putative active site [active]
176299006274	putative substrate binding site [chemical binding]; other site
176299006275	ATP binding site [chemical binding]; other site
176299006276	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
176299006277	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
176299006278	nucleotide binding pocket [chemical binding]; other site
176299006279	K-X-D-G motif; other site
176299006280	catalytic site [active]
176299006281	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
176299006282	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
176299006283	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
176299006284	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
176299006285	Dimer interface [polypeptide binding]; other site
176299006286	BRCT sequence motif; other site
176299006287	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
176299006288	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
176299006289	Walker A/P-loop; other site
176299006290	ATP binding site [chemical binding]; other site
176299006291	Q-loop/lid; other site
176299006292	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
176299006293	Q-loop/lid; other site
176299006294	ABC transporter signature motif; other site
176299006295	Walker B; other site
176299006296	D-loop; other site
176299006297	H-loop/switch region; other site
176299006298	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
176299006299	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774
176299006300	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
176299006301	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
176299006302	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
176299006303	nucleotide binding site [chemical binding]; other site
176299006304	SulA interaction site; other site
176299006305	cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483
176299006306	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
176299006307	Cell division protein FtsA; Region: FtsA; smart00842
176299006308	Cell division protein FtsA; Region: FtsA; pfam14450
176299006309	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
176299006310	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
176299006311	Cell division protein FtsQ; Region: FtsQ; pfam03799
176299006312	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
176299006313	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
176299006314	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299006315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299006316	metabolite-proton symporter; Region: 2A0106; TIGR00883
176299006317	putative substrate translocation pore; other site
176299006318	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299006319	metal binding site [ion binding]; metal-binding site
176299006320	active site
176299006321	I-site; other site
176299006322	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
176299006323	FAD binding domain; Region: FAD_binding_4; cl19922
176299006324	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
176299006325	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
176299006326	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
176299006327	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
176299006328	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
176299006329	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
176299006330	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
176299006331	active site
176299006332	homodimer interface [polypeptide binding]; other site
176299006333	cell division protein FtsW; Region: ftsW; TIGR02614
176299006334	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
176299006335	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
176299006336	NAD(P) binding pocket [chemical binding]; other site
176299006337	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
176299006338	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
176299006339	Mg++ binding site [ion binding]; other site
176299006340	putative catalytic motif [active]
176299006341	putative substrate binding site [chemical binding]; other site
176299006342	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
176299006343	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
176299006344	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
176299006345	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
176299006346	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
176299006347	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
176299006348	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
176299006349	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
176299006350	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
176299006351	Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
176299006352	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
176299006353	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
176299006354	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
176299006355	cell division protein MraZ; Reviewed; Region: PRK00326
176299006356	MraZ protein; Region: MraZ; pfam02381
176299006357	Predicted membrane protein [Function unknown]; Region: COG3766
176299006358	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
176299006359	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
176299006360	Predicted integral membrane protein [Function unknown]; Region: COG5463
176299006361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299006362	Helix-turn-helix domain; Region: HTH_28; pfam13518
176299006363	putative transposase OrfB; Reviewed; Region: PHA02517
176299006364	HTH-like domain; Region: HTH_21; pfam13276
176299006365	Integrase core domain; Region: rve; pfam00665
176299006366	Integrase core domain; Region: rve_2; pfam13333
176299006367	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299006368	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299006369	FAD dependent oxidoreductase; Region: DAO; pfam01266
176299006370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299006371	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
176299006372	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299006373	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299006374	catalytic residue [active]
176299006375	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
176299006376	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
176299006377	amidase catalytic site [active]
176299006378	Zn binding residues [ion binding]; other site
176299006379	substrate binding site [chemical binding]; other site
176299006380	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299006381	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
176299006382	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
176299006383	putative metal binding site [ion binding]; other site
176299006384	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
176299006385	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
176299006386	active site
176299006387	ADP/pyrophosphate binding site [chemical binding]; other site
176299006388	dimerization interface [polypeptide binding]; other site
176299006389	allosteric effector site; other site
176299006390	fructose-1,6-bisphosphate binding site; other site
176299006391	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299006392	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
176299006393	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299006394	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299006395	catalytic residue [active]
176299006396	S-adenosylmethionine:diacylglycerol 3-amino-3-carboxypropyl transferase [Lipid metabolism]; Region: BtaA; COG5379
176299006397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299006398	S-adenosylmethionine binding site [chemical binding]; other site
176299006399	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
176299006400	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
176299006401	active site
176299006402	lytic murein transglycosylase; Region: MltB_2; TIGR02283
176299006403	Transglycosylase SLT domain; Region: SLT_2; pfam13406
176299006404	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299006405	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
176299006406	FAD binding site [chemical binding]; other site
176299006407	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299006408	dimerization interface [polypeptide binding]; other site
176299006409	putative DNA binding site [nucleotide binding]; other site
176299006410	putative Zn2+ binding site [ion binding]; other site
176299006411	Methyltransferase domain; Region: Methyltransf_31; pfam13847
176299006412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299006413	S-adenosylmethionine binding site [chemical binding]; other site
176299006414	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
176299006415	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299006416	ABC transporter; Region: ABC_tran_2; pfam12848
176299006417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299006418	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
176299006419	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
176299006420	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
176299006421	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
176299006422	thiamine pyrophosphate protein; Validated; Region: PRK08199
176299006423	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
176299006424	PYR/PP interface [polypeptide binding]; other site
176299006425	dimer interface [polypeptide binding]; other site
176299006426	TPP binding site [chemical binding]; other site
176299006427	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
176299006428	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
176299006429	TPP-binding site [chemical binding]; other site
176299006430	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
176299006431	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
176299006432	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
176299006433	homotrimer interaction site [polypeptide binding]; other site
176299006434	putative active site [active]
176299006435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
176299006436	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
176299006437	active site
176299006438	catalytic residues [active]
176299006439	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
176299006440	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299006441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299006442	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299006443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299006444	putative substrate translocation pore; other site
176299006445	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299006446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299006447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299006448	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
176299006449	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
176299006450	P-loop; other site
176299006451	Magnesium ion binding site [ion binding]; other site
176299006452	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
176299006453	putative active site [active]
176299006454	metal binding site [ion binding]; metal-binding site
176299006455	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
176299006456	NAD(P) binding site [chemical binding]; other site
176299006457	catalytic residues [active]
176299006458	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
176299006459	putative active site [active]
176299006460	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299006461	salt bridge; other site
176299006462	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299006463	non-specific DNA binding site [nucleotide binding]; other site
176299006464	sequence-specific DNA binding site [nucleotide binding]; other site
176299006465	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
176299006466	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
176299006467	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
176299006468	ethanolamine permease; Region: 2A0305; TIGR00908
176299006469	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
176299006470	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
176299006471	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
176299006472	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
176299006473	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
176299006474	putative active site [active]
176299006475	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299006476	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299006477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299006478	dimer interface [polypeptide binding]; other site
176299006479	conserved gate region; other site
176299006480	putative PBP binding loops; other site
176299006481	ABC-ATPase subunit interface; other site
176299006482	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299006483	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299006484	dimer interface [polypeptide binding]; other site
176299006485	conserved gate region; other site
176299006486	putative PBP binding loops; other site
176299006487	ABC-ATPase subunit interface; other site
176299006488	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299006489	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299006490	Walker A/P-loop; other site
176299006491	ATP binding site [chemical binding]; other site
176299006492	Q-loop/lid; other site
176299006493	ABC transporter signature motif; other site
176299006494	Walker B; other site
176299006495	D-loop; other site
176299006496	H-loop/switch region; other site
176299006497	TOBE domain; Region: TOBE_2; pfam08402
176299006498	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
176299006499	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
176299006500	putative NAD(P) binding site [chemical binding]; other site
176299006501	catalytic Zn binding site [ion binding]; other site
176299006502	structural Zn binding site [ion binding]; other site
176299006503	Predicted ATPase [General function prediction only]; Region: COG3910
176299006504	Walker A/P-loop; other site
176299006505	ATP binding site [chemical binding]; other site
176299006506	Q-loop/lid; other site
176299006507	ABC transporter signature motif; other site
176299006508	Walker B; other site
176299006509	D-loop; other site
176299006510	H-loop/switch region; other site
176299006511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299006512	metabolite-proton symporter; Region: 2A0106; TIGR00883
176299006513	putative substrate translocation pore; other site
176299006514	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
176299006515	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
176299006516	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
176299006517	substrate binding pocket [chemical binding]; other site
176299006518	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
176299006519	B12 binding site [chemical binding]; other site
176299006520	cobalt ligand [ion binding]; other site
176299006521	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
176299006522	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
176299006523	dimerization interface [polypeptide binding]; other site
176299006524	putative active cleft [active]
176299006525	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
176299006526	Tyrosine phosphatase family; Region: Y_phosphatase3; cl19170
176299006527	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
176299006528	Uncharacterized conserved protein [Function unknown]; Region: COG2968
176299006529	Uncharacterized conserved protein [Function unknown]; Region: COG0432
176299006530	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
176299006531	PAS fold; Region: PAS_2; pfam08446
176299006532	GAF domain; Region: GAF; pfam01590
176299006533	Phytochrome region; Region: PHY; pfam00360
176299006534	HWE histidine kinase; Region: HWE_HK; pfam07536
176299006535	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
176299006536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299006537	active site
176299006538	phosphorylation site [posttranslational modification]
176299006539	intermolecular recognition site; other site
176299006540	dimerization interface [polypeptide binding]; other site
176299006541	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
176299006542	Domain of Unknown Function (DUF930); Region: DUF930; pfam06059
176299006543	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
176299006544	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
176299006545	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
176299006546	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
176299006547	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299006548	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
176299006549	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299006550	DNA binding residues [nucleotide binding]
176299006551	DNA primase; Validated; Region: dnaG; PRK05667
176299006552	CHC2 zinc finger; Region: zf-CHC2; cl17510
176299006553	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
176299006554	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
176299006555	active site
176299006556	metal binding site [ion binding]; metal-binding site
176299006557	interdomain interaction site; other site
176299006558	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
176299006559	Uncharacterized conserved protein [Function unknown]; Region: COG1610
176299006560	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
176299006561	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
176299006562	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
176299006563	catalytic site [active]
176299006564	subunit interface [polypeptide binding]; other site
176299006565	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299006566	TAP-like protein; Region: Abhydrolase_4; pfam08386
176299006567	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
176299006568	multidrug efflux protein; Reviewed; Region: PRK01766
176299006569	cation binding site [ion binding]; other site
176299006570	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
176299006571	Cache domain; Region: Cache_1; pfam02743
176299006572	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299006573	dimerization interface [polypeptide binding]; other site
176299006574	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299006575	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299006576	dimer interface [polypeptide binding]; other site
176299006577	putative CheW interface [polypeptide binding]; other site
176299006578	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
176299006579	Predicted metalloprotease [General function prediction only]; Region: COG2321
176299006580	Predicted membrane protein [Function unknown]; Region: COG5395
176299006581	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
176299006582	LytTr DNA-binding domain; Region: LytTR; smart00850
176299006583	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
176299006584	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299006585	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299006586	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
176299006587	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299006588	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299006589	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
176299006590	IMP binding site; other site
176299006591	dimer interface [polypeptide binding]; other site
176299006592	partial ornithine binding site; other site
176299006593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
176299006594	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299006595	metal binding site [ion binding]; metal-binding site
176299006596	active site
176299006597	I-site; other site
176299006598	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
176299006599	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
176299006600	Fe-S cluster binding site [ion binding]; other site
176299006601	active site
176299006602	Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277
176299006603	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299006604	FeS/SAM binding site; other site
176299006605	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
176299006606	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
176299006607	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
176299006608	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299006609	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
176299006610	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299006611	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299006612	putative DNA binding site [nucleotide binding]; other site
176299006613	putative Zn2+ binding site [ion binding]; other site
176299006614	AsnC family; Region: AsnC_trans_reg; pfam01037
176299006615	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
176299006616	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299006617	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299006618	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299006619	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299006620	putative effector binding pocket; other site
176299006621	dimerization interface [polypeptide binding]; other site
176299006622	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299006623	dimerization interface [polypeptide binding]; other site
176299006624	putative DNA binding site [nucleotide binding]; other site
176299006625	putative Zn2+ binding site [ion binding]; other site
176299006626	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
176299006627	FMN binding site [chemical binding]; other site
176299006628	active site
176299006629	substrate binding site [chemical binding]; other site
176299006630	catalytic residue [active]
176299006631	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299006632	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299006633	NAD(P) binding site [chemical binding]; other site
176299006634	active site
176299006635	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299006636	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299006637	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299006638	dimerization interface [polypeptide binding]; other site
176299006639	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
176299006640	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
176299006641	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
176299006642	aspartate aminotransferase; Provisional; Region: PRK05764
176299006643	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299006644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299006645	homodimer interface [polypeptide binding]; other site
176299006646	catalytic residue [active]
176299006647	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299006648	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299006649	EamA-like transporter family; Region: EamA; pfam00892
176299006650	EamA-like transporter family; Region: EamA; pfam00892
176299006651	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
176299006652	DNA-binding site [nucleotide binding]; DNA binding site
176299006653	RNA-binding motif; other site
176299006654	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
176299006655	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
176299006656	Bacterial SH3 domain; Region: SH3_3; pfam08239
176299006657	Protein of unknown function (DUF1236); Region: DUF1236; pfam06823
176299006658	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299006659	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
176299006660	putative Zn2+ binding site [ion binding]; other site
176299006661	putative DNA binding site [nucleotide binding]; other site
176299006662	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299006663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299006664	active site
176299006665	phosphorylation site [posttranslational modification]
176299006666	intermolecular recognition site; other site
176299006667	dimerization interface [polypeptide binding]; other site
176299006668	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299006669	DNA binding site [nucleotide binding]
176299006670	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299006671	HAMP domain; Region: HAMP; pfam00672
176299006672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299006673	dimer interface [polypeptide binding]; other site
176299006674	phosphorylation site [posttranslational modification]
176299006675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299006676	ATP binding site [chemical binding]; other site
176299006677	Mg2+ binding site [ion binding]; other site
176299006678	G-X-G motif; other site
176299006679	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
176299006680	dimer interface [polypeptide binding]; other site
176299006681	putative tRNA-binding site [nucleotide binding]; other site
176299006682	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
176299006683	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
176299006684	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
176299006685	Uncharacterized conserved protein [Function unknown]; Region: COG5465
176299006686	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
176299006687	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
176299006688	Uncharacterized conserved protein [Function unknown]; Region: COG1565
176299006689	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
176299006690	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
176299006691	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
176299006692	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299006693	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
176299006694	active site
176299006695	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
176299006696	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
176299006697	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299006698	active site
176299006699	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
176299006700	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
176299006701	active site
176299006702	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
176299006703	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
176299006704	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
176299006705	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
176299006706	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
176299006707	Ligand binding site; other site
176299006708	Putative Catalytic site; other site
176299006709	DXD motif; other site
176299006710	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951
176299006711	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299006712	dimerization interface [polypeptide binding]; other site
176299006713	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
176299006714	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299006715	dimer interface [polypeptide binding]; other site
176299006716	putative CheW interface [polypeptide binding]; other site
176299006717	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
176299006718	NAD(P) binding site [chemical binding]; other site
176299006719	catalytic residues [active]
176299006720	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
176299006721	GAF domain; Region: GAF; pfam01590
176299006722	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
176299006723	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
176299006724	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
176299006725	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
176299006726	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299006727	metal binding site [ion binding]; metal-binding site
176299006728	active site
176299006729	I-site; other site
176299006730	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299006731	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
176299006732	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
176299006733	5S rRNA interface [nucleotide binding]; other site
176299006734	CTC domain interface [polypeptide binding]; other site
176299006735	L16 interface [polypeptide binding]; other site
176299006736	Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
176299006737	SmpA / OmlA family; Region: SmpA_OmlA; cl19285
176299006738	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299006739	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299006740	dimerization interface [polypeptide binding]; other site
176299006741	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299006742	putative active site [active]
176299006743	heme pocket [chemical binding]; other site
176299006744	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299006745	metal binding site [ion binding]; metal-binding site
176299006746	active site
176299006747	I-site; other site
176299006748	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299006749	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299006750	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299006751	substrate binding pocket [chemical binding]; other site
176299006752	membrane-bound complex binding site; other site
176299006753	hinge residues; other site
176299006754	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
176299006755	putative active site [active]
176299006756	catalytic residue [active]
176299006757	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299006758	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299006759	Coenzyme A binding pocket [chemical binding]; other site
176299006760	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
176299006761	GTP-binding protein YchF; Reviewed; Region: PRK09601
176299006762	YchF GTPase; Region: YchF; cd01900
176299006763	G1 box; other site
176299006764	GTP/Mg2+ binding site [chemical binding]; other site
176299006765	Switch I region; other site
176299006766	G2 box; other site
176299006767	Switch II region; other site
176299006768	G3 box; other site
176299006769	G4 box; other site
176299006770	G5 box; other site
176299006771	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
176299006772	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
176299006773	putative active site [active]
176299006774	putative catalytic site [active]
176299006775	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
176299006776	putative active site [active]
176299006777	putative catalytic site [active]
176299006778	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299006779	active site
176299006780	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
176299006781	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
176299006782	cytochrome b; Provisional; Region: CYTB; MTH00191
176299006783	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
176299006784	Qi binding site; other site
176299006785	intrachain domain interface; other site
176299006786	interchain domain interface [polypeptide binding]; other site
176299006787	heme bH binding site [chemical binding]; other site
176299006788	heme bL binding site [chemical binding]; other site
176299006789	Qo binding site; other site
176299006790	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
176299006791	interchain domain interface [polypeptide binding]; other site
176299006792	intrachain domain interface; other site
176299006793	Qi binding site; other site
176299006794	Qo binding site; other site
176299006795	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
176299006796	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
176299006797	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
176299006798	[2Fe-2S] cluster binding site [ion binding]; other site
176299006799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3021
176299006800	putative catalytic site [active]
176299006801	putative metal binding site [ion binding]; other site
176299006802	putative phosphate binding site [ion binding]; other site
176299006803	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
176299006804	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299006805	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299006806	Walker A/P-loop; other site
176299006807	ATP binding site [chemical binding]; other site
176299006808	Q-loop/lid; other site
176299006809	ABC transporter signature motif; other site
176299006810	Walker B; other site
176299006811	D-loop; other site
176299006812	H-loop/switch region; other site
176299006813	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
176299006814	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299006815	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299006816	Walker A/P-loop; other site
176299006817	ATP binding site [chemical binding]; other site
176299006818	Q-loop/lid; other site
176299006819	ABC transporter signature motif; other site
176299006820	Walker B; other site
176299006821	D-loop; other site
176299006822	H-loop/switch region; other site
176299006823	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
176299006824	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
176299006825	active site
176299006826	metal binding site [ion binding]; metal-binding site
176299006827	hexamer interface [polypeptide binding]; other site
176299006828	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
176299006829	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
176299006830	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
176299006831	PhoU domain; Region: PhoU; pfam01895
176299006832	PhoU domain; Region: PhoU; pfam01895
176299006833	Coproporphyrinogen III oxidase [Coenzyme metabolism]; Region: HemF; COG0408
176299006834	Predicted small metal-binding protein [Function unknown]; Region: COG5466
176299006835	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
176299006836	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
176299006837	active site
176299006838	NTP binding site [chemical binding]; other site
176299006839	metal binding triad [ion binding]; metal-binding site
176299006840	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
176299006841	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
176299006842	putative active site [active]
176299006843	putative CoA binding site [chemical binding]; other site
176299006844	nudix motif; other site
176299006845	metal binding site [ion binding]; metal-binding site
176299006846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
176299006847	MoxR-like ATPases [General function prediction only]; Region: COG0714
176299006848	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299006849	Walker A motif; other site
176299006850	ATP binding site [chemical binding]; other site
176299006851	Walker B motif; other site
176299006852	arginine finger; other site
176299006853	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
176299006854	Protein of unknown function DUF58; Region: DUF58; pfam01882
176299006855	N-terminal double-transmembrane domain; Region: two_anch; TIGR02226
176299006856	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
176299006857	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
176299006858	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
176299006859	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299006860	Coenzyme A binding pocket [chemical binding]; other site
176299006861	benzoate transport; Region: 2A0115; TIGR00895
176299006862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299006863	putative substrate translocation pore; other site
176299006864	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
176299006865	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299006866	Coenzyme A binding pocket [chemical binding]; other site
176299006867	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
176299006868	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
176299006869	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
176299006870	putative dimer interface [polypeptide binding]; other site
176299006871	N-terminal domain interface [polypeptide binding]; other site
176299006872	putative substrate binding pocket (H-site) [chemical binding]; other site
176299006873	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
176299006874	nudix motif; other site
176299006875	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
176299006876	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
176299006877	putative active site [active]
176299006878	putative metal binding site [ion binding]; other site
176299006879	2-isopropylmalate synthase; Validated; Region: PRK03739
176299006880	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
176299006881	active site
176299006882	catalytic residues [active]
176299006883	metal binding site [ion binding]; metal-binding site
176299006884	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
176299006885	Sulfate transporter family; Region: Sulfate_transp; cl19250
176299006886	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
176299006887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
176299006888	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
176299006889	putative active site [active]
176299006890	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4944
176299006891	RNA polymerase sigma factor; Provisional; Region: PRK12536
176299006892	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299006893	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
176299006894	DNA binding residues [nucleotide binding]
176299006895	pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953
176299006896	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
176299006897	oligomer interface [polypeptide binding]; other site
176299006898	active site residues [active]
176299006899	HupE / UreJ protein; Region: HupE_UreJ; cl01011
176299006900	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3416
176299006901	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
176299006902	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
176299006903	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
176299006904	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
176299006905	dimer interface [polypeptide binding]; other site
176299006906	ligand binding site [chemical binding]; other site
176299006907	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
176299006908	dimerization interface [polypeptide binding]; other site
176299006909	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
176299006910	ligand binding site [chemical binding]; other site
176299006911	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
176299006912	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299006913	dimerization interface [polypeptide binding]; other site
176299006914	putative DNA binding site [nucleotide binding]; other site
176299006915	putative Zn2+ binding site [ion binding]; other site
176299006916	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
176299006917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299006918	Walker A/P-loop; other site
176299006919	ATP binding site [chemical binding]; other site
176299006920	Q-loop/lid; other site
176299006921	ABC transporter signature motif; other site
176299006922	Walker B; other site
176299006923	D-loop; other site
176299006924	H-loop/switch region; other site
176299006925	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299006926	dimer interface [polypeptide binding]; other site
176299006927	conserved gate region; other site
176299006928	putative PBP binding loops; other site
176299006929	ABC-ATPase subunit interface; other site
176299006930	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
176299006931	thymidine kinase; Provisional; Region: PRK04296
176299006932	Pseudoazurin (Paz) is a type I blue copper electron-transfer protein; Region: Pseudoazurin; cd04218
176299006933	Type 1 (T1) Cu binding site [ion binding]; other site
176299006934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5345
176299006935	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
176299006936	Autoinducer binding domain; Region: Autoind_bind; pfam03472
176299006937	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299006938	DNA binding residues [nucleotide binding]
176299006939	dimerization interface [polypeptide binding]; other site
176299006940	hypothetical protein; Provisional; Region: PRK05208
176299006941	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
176299006942	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
176299006943	N-terminal plug; other site
176299006944	ligand-binding site [chemical binding]; other site
176299006945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3921
176299006946	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
176299006947	anthranilate synthase; Provisional; Region: PRK13566
176299006948	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
176299006949	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
176299006950	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
176299006951	glutamine binding [chemical binding]; other site
176299006952	catalytic triad [active]
176299006953	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299006954	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299006955	Coenzyme A binding pocket [chemical binding]; other site
176299006956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299006957	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
176299006958	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
176299006959	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
176299006960	Zn2+ binding site [ion binding]; other site
176299006961	Mg2+ binding site [ion binding]; other site
176299006962	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
176299006963	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
176299006964	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
176299006965	active site
176299006966	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299006967	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299006968	Coenzyme A binding pocket [chemical binding]; other site
176299006969	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
176299006970	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
176299006971	active site
176299006972	catalytic site [active]
176299006973	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
176299006974	substrate binding site [chemical binding]; other site
176299006975	ATP binding site [chemical binding]; other site
176299006976	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
176299006977	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299006978	Protein of unknown function (DUF2026); Region: DUF2026; pfam09641
176299006979	GTP-binding protein Der; Reviewed; Region: PRK00093
176299006980	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
176299006981	G1 box; other site
176299006982	GTP/Mg2+ binding site [chemical binding]; other site
176299006983	Switch I region; other site
176299006984	G2 box; other site
176299006985	Switch II region; other site
176299006986	G3 box; other site
176299006987	G4 box; other site
176299006988	G5 box; other site
176299006989	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
176299006990	G1 box; other site
176299006991	GTP/Mg2+ binding site [chemical binding]; other site
176299006992	Switch I region; other site
176299006993	G2 box; other site
176299006994	G3 box; other site
176299006995	Switch II region; other site
176299006996	G4 box; other site
176299006997	G5 box; other site
176299006998	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
176299006999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
176299007000	Predicted membrane protein [Function unknown]; Region: COG4094
176299007001	Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976
176299007002	NodB motif; other site
176299007003	putative active site [active]
176299007004	putative catalytic site [active]
176299007005	microcin B17 transporter; Reviewed; Region: PRK11098
176299007006	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299007007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299007008	putative substrate translocation pore; other site
176299007009	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
176299007010	active site
176299007011	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
176299007012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299007013	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
176299007014	NAD(P) binding site [chemical binding]; other site
176299007015	active site
176299007016	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
176299007017	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299007018	catalytic loop [active]
176299007019	iron binding site [ion binding]; other site
176299007020	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
176299007021	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
176299007022	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
176299007023	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
176299007024	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
176299007025	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
176299007026	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
176299007027	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
176299007028	XdhC Rossmann domain; Region: XdhC_C; pfam13478
176299007029	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299007030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299007031	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
176299007032	dimerization interface [polypeptide binding]; other site
176299007033	substrate binding pocket [chemical binding]; other site
176299007034	Predicted membrane protein [Function unknown]; Region: COG3748
176299007035	Protein of unknown function (DUF989); Region: DUF989; pfam06181
176299007036	Cytochrome c; Region: Cytochrom_C; pfam00034
176299007037	guanine deaminase; Provisional; Region: PRK09228
176299007038	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
176299007039	active site
176299007040	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
176299007041	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
176299007042	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
176299007043	active site
176299007044	substrate binding site [chemical binding]; other site
176299007045	FMN binding site [chemical binding]; other site
176299007046	putative catalytic residues [active]
176299007047	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
176299007048	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299007049	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299007050	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
176299007051	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
176299007052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
176299007053	Sporulation related domain; Region: SPOR; pfam05036
176299007054	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
176299007055	active site
176299007056	metal binding site [ion binding]; metal-binding site
176299007057	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
176299007058	active site
176299007059	homotetramer interface [polypeptide binding]; other site
176299007060	ureidoglycolate hydrolase; Provisional; Region: PRK03606
176299007061	Uncharacterized conserved protein [Function unknown]; Region: COG2361
176299007062	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
176299007063	active site
176299007064	NTP binding site [chemical binding]; other site
176299007065	metal binding triad [ion binding]; metal-binding site
176299007066	antibiotic binding site [chemical binding]; other site
176299007067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
176299007068	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
176299007069	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
176299007070	active site
176299007071	catalytic site [active]
176299007072	tetramer interface [polypeptide binding]; other site
176299007073	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
176299007074	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299007075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299007076	Uncharacterized conserved protein [Function unknown]; Region: COG4121
176299007077	PAS fold; Region: PAS_7; pfam12860
176299007078	PAS fold; Region: PAS_4; pfam08448
176299007079	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299007080	putative active site [active]
176299007081	heme pocket [chemical binding]; other site
176299007082	PAS domain; Region: PAS_8; pfam13188
176299007083	PAS fold; Region: PAS_7; pfam12860
176299007084	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
176299007085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299007086	dimer interface [polypeptide binding]; other site
176299007087	phosphorylation site [posttranslational modification]
176299007088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299007089	ATP binding site [chemical binding]; other site
176299007090	Mg2+ binding site [ion binding]; other site
176299007091	G-X-G motif; other site
176299007092	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299007093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299007094	active site
176299007095	phosphorylation site [posttranslational modification]
176299007096	intermolecular recognition site; other site
176299007097	dimerization interface [polypeptide binding]; other site
176299007098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299007099	active site
176299007100	phosphorylation site [posttranslational modification]
176299007101	intermolecular recognition site; other site
176299007102	dimerization interface [polypeptide binding]; other site
176299007103	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
176299007104	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
176299007105	ATP binding site [chemical binding]; other site
176299007106	Mg++ binding site [ion binding]; other site
176299007107	motif III; other site
176299007108	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299007109	nucleotide binding region [chemical binding]; other site
176299007110	ATP-binding site [chemical binding]; other site
176299007111	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
176299007112	EamA-like transporter family; Region: EamA; pfam00892
176299007113	EamA-like transporter family; Region: EamA; pfam00892
176299007114	Predicted membrane protein [Function unknown]; Region: COG2259
176299007115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299007116	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299007117	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299007118	EamA-like transporter family; Region: EamA; pfam00892
176299007119	EamA-like transporter family; Region: EamA; pfam00892
176299007120	Uncharacterized conserved protein [Function unknown]; Region: COG2308
176299007121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
176299007122	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
176299007123	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
176299007124	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
176299007125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299007126	S-adenosylmethionine binding site [chemical binding]; other site
176299007127	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299007128	Coenzyme A binding pocket [chemical binding]; other site
176299007129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299007130	Coenzyme A binding pocket [chemical binding]; other site
176299007131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299007132	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354
176299007133	putative metal binding site [ion binding]; other site
176299007134	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
176299007135	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299007136	TM-ABC transporter signature motif; other site
176299007137	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299007138	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299007139	Walker A/P-loop; other site
176299007140	ATP binding site [chemical binding]; other site
176299007141	Q-loop/lid; other site
176299007142	ABC transporter signature motif; other site
176299007143	Walker B; other site
176299007144	D-loop; other site
176299007145	H-loop/switch region; other site
176299007146	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299007147	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
176299007148	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
176299007149	putative ligand binding site [chemical binding]; other site
176299007150	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299007151	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299007152	The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435
176299007153	putative dimerization interface [polypeptide binding]; other site
176299007154	Guanylate-binding protein, N-terminal domain; Region: GBP; cl19296
176299007155	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299007156	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299007157	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
176299007158	O-Antigen ligase; Region: Wzy_C; pfam04932
176299007159	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
176299007160	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299007161	dimerization interface [polypeptide binding]; other site
176299007162	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299007163	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299007164	dimer interface [polypeptide binding]; other site
176299007165	putative CheW interface [polypeptide binding]; other site
176299007166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299007167	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299007168	putative substrate translocation pore; other site
176299007169	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
176299007170	ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160
176299007171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007172	dimer interface [polypeptide binding]; other site
176299007173	conserved gate region; other site
176299007174	putative PBP binding loops; other site
176299007175	ABC-ATPase subunit interface; other site
176299007176	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
176299007177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007178	dimer interface [polypeptide binding]; other site
176299007179	conserved gate region; other site
176299007180	putative PBP binding loops; other site
176299007181	ABC-ATPase subunit interface; other site
176299007182	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
176299007183	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299007184	substrate binding pocket [chemical binding]; other site
176299007185	membrane-bound complex binding site; other site
176299007186	hinge residues; other site
176299007187	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
176299007188	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299007189	Walker A/P-loop; other site
176299007190	ATP binding site [chemical binding]; other site
176299007191	Q-loop/lid; other site
176299007192	ABC transporter signature motif; other site
176299007193	Walker B; other site
176299007194	D-loop; other site
176299007195	H-loop/switch region; other site
176299007196	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299007197	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299007198	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299007199	Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693
176299007200	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
176299007201	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299007202	active site
176299007203	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
176299007204	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299007205	active site
176299007206	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299007207	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
176299007208	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
176299007209	Chain length determinant protein; Region: Wzz; pfam02706
176299007210	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
176299007211	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
176299007212	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
176299007213	active site
176299007214	substrate binding site [chemical binding]; other site
176299007215	metal binding site [ion binding]; metal-binding site
176299007216	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
176299007217	apolar tunnel; other site
176299007218	heme binding site [chemical binding]; other site
176299007219	dimerization interface [polypeptide binding]; other site
176299007220	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
176299007221	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
176299007222	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
176299007223	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299007224	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
176299007225	allantoate amidohydrolase; Reviewed; Region: PRK12893
176299007226	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
176299007227	active site
176299007228	metal binding site [ion binding]; metal-binding site
176299007229	dimer interface [polypeptide binding]; other site
176299007230	phenylhydantoinase; Validated; Region: PRK08323
176299007231	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
176299007232	tetramer interface [polypeptide binding]; other site
176299007233	active site
176299007234	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
176299007235	nudix motif; other site
176299007236	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299007237	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299007238	Walker A/P-loop; other site
176299007239	ATP binding site [chemical binding]; other site
176299007240	Q-loop/lid; other site
176299007241	ABC transporter signature motif; other site
176299007242	Walker B; other site
176299007243	D-loop; other site
176299007244	H-loop/switch region; other site
176299007245	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299007246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007247	dimer interface [polypeptide binding]; other site
176299007248	conserved gate region; other site
176299007249	putative PBP binding loops; other site
176299007250	ABC-ATPase subunit interface; other site
176299007251	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299007252	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007253	dimer interface [polypeptide binding]; other site
176299007254	conserved gate region; other site
176299007255	putative PBP binding loops; other site
176299007256	ABC-ATPase subunit interface; other site
176299007257	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299007258	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299007259	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299007260	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299007261	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299007262	MMPL family; Region: MMPL; cl14618
176299007263	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299007264	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299007265	ligand binding site [chemical binding]; other site
176299007266	flexible hinge region; other site
176299007267	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
176299007268	putative switch regulator; other site
176299007269	non-specific DNA interactions [nucleotide binding]; other site
176299007270	DNA binding site [nucleotide binding]
176299007271	sequence specific DNA binding site [nucleotide binding]; other site
176299007272	putative cAMP binding site [chemical binding]; other site
176299007273	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
176299007274	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299007275	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
176299007276	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
176299007277	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
176299007278	dimer interface [polypeptide binding]; other site
176299007279	catalytic residues [active]
176299007280	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
176299007281	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
176299007282	catalytic triad [active]
176299007283	dimer interface [polypeptide binding]; other site
176299007284	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
176299007285	urease subunit alpha; Reviewed; Region: ureC; PRK13207
176299007286	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
176299007287	subunit interactions [polypeptide binding]; other site
176299007288	active site
176299007289	flap region; other site
176299007290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
176299007291	Uncharacterized conserved protein [Function unknown]; Region: COG3791
176299007292	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
176299007293	gamma-beta subunit interface [polypeptide binding]; other site
176299007294	alpha-beta subunit interface [polypeptide binding]; other site
176299007295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
176299007296	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
176299007297	alpha-gamma subunit interface [polypeptide binding]; other site
176299007298	beta-gamma subunit interface [polypeptide binding]; other site
176299007299	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
176299007300	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
176299007301	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
176299007302	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
176299007303	Walker A/P-loop; other site
176299007304	ATP binding site [chemical binding]; other site
176299007305	Q-loop/lid; other site
176299007306	ABC transporter signature motif; other site
176299007307	Walker B; other site
176299007308	D-loop; other site
176299007309	H-loop/switch region; other site
176299007310	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
176299007311	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
176299007312	Walker A/P-loop; other site
176299007313	ATP binding site [chemical binding]; other site
176299007314	Q-loop/lid; other site
176299007315	ABC transporter signature motif; other site
176299007316	Walker B; other site
176299007317	D-loop; other site
176299007318	H-loop/switch region; other site
176299007319	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
176299007320	TM-ABC transporter signature motif; other site
176299007321	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299007322	TM-ABC transporter signature motif; other site
176299007323	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
176299007324	putative ligand binding site [chemical binding]; other site
176299007325	Protein of unknown function (DUF2735); Region: DUF2735; pfam10931
176299007326	glutamine synthetase; Region: PLN02284
176299007327	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
176299007328	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
176299007329	gluconate 5-dehydrogenase; Provisional; Region: PRK06124
176299007330	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299007331	NAD(P) binding site [chemical binding]; other site
176299007332	active site
176299007333	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
176299007334	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
176299007335	Na binding site [ion binding]; other site
176299007336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299007337	dimer interface [polypeptide binding]; other site
176299007338	phosphorylation site [posttranslational modification]
176299007339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299007340	ATP binding site [chemical binding]; other site
176299007341	Mg2+ binding site [ion binding]; other site
176299007342	G-X-G motif; other site
176299007343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299007344	active site
176299007345	phosphorylation site [posttranslational modification]
176299007346	intermolecular recognition site; other site
176299007347	dimerization interface [polypeptide binding]; other site
176299007348	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299007349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299007350	active site
176299007351	phosphorylation site [posttranslational modification]
176299007352	intermolecular recognition site; other site
176299007353	dimerization interface [polypeptide binding]; other site
176299007354	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299007355	DNA binding residues [nucleotide binding]
176299007356	dimerization interface [polypeptide binding]; other site
176299007357	Predicted ATPase [General function prediction only]; Region: COG3911
176299007358	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
176299007359	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
176299007360	NodB motif; other site
176299007361	putative active site [active]
176299007362	putative catalytic site [active]
176299007363	putative Zn binding site [ion binding]; other site
176299007364	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
176299007365	dimerization interface [polypeptide binding]; other site
176299007366	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
176299007367	ligand binding site [chemical binding]; other site
176299007368	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
176299007369	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
176299007370	Walker A/P-loop; other site
176299007371	ATP binding site [chemical binding]; other site
176299007372	Q-loop/lid; other site
176299007373	ABC transporter signature motif; other site
176299007374	Walker B; other site
176299007375	D-loop; other site
176299007376	H-loop/switch region; other site
176299007377	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
176299007378	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
176299007379	Walker A/P-loop; other site
176299007380	ATP binding site [chemical binding]; other site
176299007381	Q-loop/lid; other site
176299007382	ABC transporter signature motif; other site
176299007383	Walker B; other site
176299007384	D-loop; other site
176299007385	H-loop/switch region; other site
176299007386	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
176299007387	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
176299007388	TM-ABC transporter signature motif; other site
176299007389	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299007390	TM-ABC transporter signature motif; other site
176299007391	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
176299007392	active site
176299007393	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
176299007394	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
176299007395	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299007396	Coenzyme A binding pocket [chemical binding]; other site
176299007397	Protein of unknown function (DUF1059); Region: DUF1059; cl02284
176299007398	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299007399	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299007400	active site
176299007401	phosphorylation site [posttranslational modification]
176299007402	intermolecular recognition site; other site
176299007403	dimerization interface [polypeptide binding]; other site
176299007404	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299007405	DNA binding site [nucleotide binding]
176299007406	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299007407	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299007408	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
176299007409	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
176299007410	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299007411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5385
176299007412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5400
176299007413	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
176299007414	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
176299007415	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
176299007416	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
176299007417	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
176299007418	RNA binding surface [nucleotide binding]; other site
176299007419	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
176299007420	active site
176299007421	Methyltransferase domain; Region: Methyltransf_24; pfam13578
176299007422	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
176299007423	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299007424	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299007425	DNA binding residues [nucleotide binding]
176299007426	Selenoprotein P, N terminal region; Region: SelP_N; pfam04592
176299007427	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
176299007428	GDP-binding site [chemical binding]; other site
176299007429	ACT binding site; other site
176299007430	IMP binding site; other site
176299007431	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299007432	EamA-like transporter family; Region: EamA; pfam00892
176299007433	EamA-like transporter family; Region: EamA; pfam00892
176299007434	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
176299007435	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299007436	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299007437	catalytic residue [active]
176299007438	Predicted esterase [General function prediction only]; Region: COG0400
176299007439	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299007440	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
176299007441	Zn binding site [ion binding]; other site
176299007442	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
176299007443	Zn binding site [ion binding]; other site
176299007444	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
176299007445	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
176299007446	FAD binding pocket [chemical binding]; other site
176299007447	FAD binding motif [chemical binding]; other site
176299007448	phosphate binding motif [ion binding]; other site
176299007449	NAD binding pocket [chemical binding]; other site
176299007450	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
176299007451	ligand binding site [chemical binding]; other site
176299007452	active site
176299007453	UGI interface [polypeptide binding]; other site
176299007454	catalytic site [active]
176299007455	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
176299007456	dimer interface [polypeptide binding]; other site
176299007457	active site
176299007458	metal binding site [ion binding]; metal-binding site
176299007459	glutathione binding site [chemical binding]; other site
176299007460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
176299007461	ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559
176299007462	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
176299007463	Walker A/P-loop; other site
176299007464	ATP binding site [chemical binding]; other site
176299007465	Q-loop/lid; other site
176299007466	ABC transporter signature motif; other site
176299007467	Walker B; other site
176299007468	D-loop; other site
176299007469	H-loop/switch region; other site
176299007470	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299007471	ABC-ATPase subunit  interface; other site
176299007472	dimer interface [polypeptide binding]; other site
176299007473	putative PBP binding regions; other site
176299007474	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
176299007475	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
176299007476	putative hemin binding site; other site
176299007477	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
176299007478	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721
176299007479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126
176299007480	Heat shock protein [Posttranslational modification, protein turnover, chaperones]; Region: HslJ; COG3187
176299007481	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
176299007482	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
176299007483	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
176299007484	putative active site [active]
176299007485	putative substrate binding site [chemical binding]; other site
176299007486	putative cosubstrate binding site; other site
176299007487	catalytic site [active]
176299007488	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
176299007489	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299007490	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299007491	dimer interface [polypeptide binding]; other site
176299007492	phosphorylation site [posttranslational modification]
176299007493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299007494	ATP binding site [chemical binding]; other site
176299007495	Mg2+ binding site [ion binding]; other site
176299007496	G-X-G motif; other site
176299007497	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299007498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299007499	active site
176299007500	phosphorylation site [posttranslational modification]
176299007501	intermolecular recognition site; other site
176299007502	dimerization interface [polypeptide binding]; other site
176299007503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299007504	DNA binding site [nucleotide binding]
176299007505	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299007506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
176299007507	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
176299007508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
176299007509	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
176299007510	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
176299007511	putative ligand binding residues [chemical binding]; other site
176299007512	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299007513	ABC-ATPase subunit  interface; other site
176299007514	dimer interface [polypeptide binding]; other site
176299007515	putative PBP binding regions; other site
176299007516	ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism]; Region: CeuC; COG4605
176299007517	ABC-ATPase subunit  interface; other site
176299007518	dimer interface [polypeptide binding]; other site
176299007519	putative PBP binding regions; other site
176299007520	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
176299007521	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
176299007522	Walker A/P-loop; other site
176299007523	ATP binding site [chemical binding]; other site
176299007524	Q-loop/lid; other site
176299007525	ABC transporter signature motif; other site
176299007526	Walker B; other site
176299007527	D-loop; other site
176299007528	H-loop/switch region; other site
176299007529	Ferritin-like domain; Region: Ferritin; pfam00210
176299007530	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
176299007531	dimerization interface [polypeptide binding]; other site
176299007532	DPS ferroxidase diiron center [ion binding]; other site
176299007533	ion pore; other site
176299007534	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299007535	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299007536	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
176299007537	putative effector binding pocket; other site
176299007538	putative dimerization interface [polypeptide binding]; other site
176299007539	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299007540	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
176299007541	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299007542	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299007543	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299007544	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299007545	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
176299007546	putative catalytic site [active]
176299007547	putative metal binding site [ion binding]; other site
176299007548	putative phosphate binding site [ion binding]; other site
176299007549	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
176299007550	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
176299007551	putative active site [active]
176299007552	catalytic site [active]
176299007553	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
176299007554	putative active site [active]
176299007555	catalytic site [active]
176299007556	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
176299007557	pyridoxal binding site [chemical binding]; other site
176299007558	dimer interface [polypeptide binding]; other site
176299007559	ATP binding site [chemical binding]; other site
176299007560	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
176299007561	active site clefts [active]
176299007562	zinc binding site [ion binding]; other site
176299007563	dimer interface [polypeptide binding]; other site
176299007564	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
176299007565	Transglycosylase SLT domain; Region: SLT_2; pfam13406
176299007566	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
176299007567	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
176299007568	Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
176299007569	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
176299007570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299007571	putative substrate translocation pore; other site
176299007572	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
176299007573	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
176299007574	ligand binding site [chemical binding]; other site
176299007575	homodimer interface [polypeptide binding]; other site
176299007576	NAD(P) binding site [chemical binding]; other site
176299007577	trimer interface B [polypeptide binding]; other site
176299007578	trimer interface A [polypeptide binding]; other site
176299007579	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
176299007580	NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566
176299007581	pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615
176299007582	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
176299007583	putative FMN binding site [chemical binding]; other site
176299007584	pyrimidine utilization protein D; Region: RutD; TIGR03611
176299007585	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299007586	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
176299007587	homotrimer interaction site [polypeptide binding]; other site
176299007588	putative active site [active]
176299007589	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
176299007590	catalytic triad [active]
176299007591	conserved cis-peptide bond; other site
176299007592	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
176299007593	active site
176299007594	dimer interface [polypeptide binding]; other site
176299007595	non-prolyl cis peptide bond; other site
176299007596	insertion regions; other site
176299007597	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
176299007598	heme binding pocket [chemical binding]; other site
176299007599	heme ligand [chemical binding]; other site
176299007600	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299007601	inhibitor site; inhibition site
176299007602	active site
176299007603	dimer interface [polypeptide binding]; other site
176299007604	catalytic residue [active]
176299007605	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299007606	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
176299007607	DNA-binding site [nucleotide binding]; DNA binding site
176299007608	FCD domain; Region: FCD; pfam07729
176299007609	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299007610	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299007611	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299007612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007613	dimer interface [polypeptide binding]; other site
176299007614	conserved gate region; other site
176299007615	putative PBP binding loops; other site
176299007616	ABC-ATPase subunit interface; other site
176299007617	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299007618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007619	dimer interface [polypeptide binding]; other site
176299007620	conserved gate region; other site
176299007621	putative PBP binding loops; other site
176299007622	ABC-ATPase subunit interface; other site
176299007623	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299007624	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299007625	Walker A/P-loop; other site
176299007626	ATP binding site [chemical binding]; other site
176299007627	Q-loop/lid; other site
176299007628	ABC transporter signature motif; other site
176299007629	Walker B; other site
176299007630	D-loop; other site
176299007631	H-loop/switch region; other site
176299007632	TOBE domain; Region: TOBE_2; pfam08402
176299007633	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
176299007634	substrate binding site [chemical binding]; other site
176299007635	ATP binding site [chemical binding]; other site
176299007636	DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603
176299007637	active site pocket [active]
176299007638	cleavage site
176299007639	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
176299007640	homodimer interface [polypeptide binding]; other site
176299007641	substrate-cofactor binding pocket; other site
176299007642	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299007643	catalytic residue [active]
176299007644	cell density-dependent motility repressor; Provisional; Region: PRK10082
176299007645	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299007646	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
176299007647	dimerization interface [polypeptide binding]; other site
176299007648	Beta-lactamase; Region: Beta-lactamase; pfam00144
176299007649	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299007650	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299007651	Walker A/P-loop; other site
176299007652	ATP binding site [chemical binding]; other site
176299007653	Q-loop/lid; other site
176299007654	ABC transporter signature motif; other site
176299007655	Walker B; other site
176299007656	D-loop; other site
176299007657	H-loop/switch region; other site
176299007658	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299007659	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299007660	Walker A/P-loop; other site
176299007661	ATP binding site [chemical binding]; other site
176299007662	Q-loop/lid; other site
176299007663	ABC transporter signature motif; other site
176299007664	Walker B; other site
176299007665	D-loop; other site
176299007666	H-loop/switch region; other site
176299007667	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299007668	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299007669	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299007670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007671	dimer interface [polypeptide binding]; other site
176299007672	conserved gate region; other site
176299007673	putative PBP binding loops; other site
176299007674	ABC-ATPase subunit interface; other site
176299007675	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299007676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007677	dimer interface [polypeptide binding]; other site
176299007678	conserved gate region; other site
176299007679	putative PBP binding loops; other site
176299007680	ABC-ATPase subunit interface; other site
176299007681	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299007682	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
176299007683	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
176299007684	active site
176299007685	dimer interface [polypeptide binding]; other site
176299007686	Predicted integral membrane protein [Function unknown]; Region: COG0392
176299007687	Uncharacterized conserved protein [Function unknown]; Region: COG2898
176299007688	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
176299007689	Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946
176299007690	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
176299007691	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299007692	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299007693	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299007694	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
176299007695	benzoate transport; Region: 2A0115; TIGR00895
176299007696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299007697	putative substrate translocation pore; other site
176299007698	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
176299007699	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
176299007700	dimer interface [polypeptide binding]; other site
176299007701	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
176299007702	active site
176299007703	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
176299007704	active site
176299007705	dimer interface [polypeptide binding]; other site
176299007706	metal binding site [ion binding]; metal-binding site
176299007707	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
176299007708	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
176299007709	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299007710	Flavin binding site [chemical binding]; other site
176299007711	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
176299007712	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299007713	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299007714	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
176299007715	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299007716	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299007717	dimer interface [polypeptide binding]; other site
176299007718	phosphorylation site [posttranslational modification]
176299007719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299007720	ATP binding site [chemical binding]; other site
176299007721	Mg2+ binding site [ion binding]; other site
176299007722	G-X-G motif; other site
176299007723	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299007724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299007725	active site
176299007726	phosphorylation site [posttranslational modification]
176299007727	intermolecular recognition site; other site
176299007728	dimerization interface [polypeptide binding]; other site
176299007729	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299007730	DNA binding site [nucleotide binding]
176299007731	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299007732	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299007733	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
176299007734	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
176299007735	putative active site [active]
176299007736	putative FMN binding site [chemical binding]; other site
176299007737	putative substrate binding site [chemical binding]; other site
176299007738	putative catalytic residue [active]
176299007739	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
176299007740	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
176299007741	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
176299007742	ATP binding site [chemical binding]; other site
176299007743	active site
176299007744	phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959
176299007745	substrate binding site [chemical binding]; other site
176299007746	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299007747	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299007748	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
176299007749	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299007750	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299007751	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299007752	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
176299007753	MMPL family; Region: MMPL; cl14618
176299007754	MMPL family; Region: MMPL; cl14618
176299007755	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
176299007756	Outer membrane efflux protein; Region: OEP; pfam02321
176299007757	Outer membrane efflux protein; Region: OEP; pfam02321
176299007758	elongation factor P; Validated; Region: PRK00529
176299007759	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
176299007760	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
176299007761	RNA binding site [nucleotide binding]; other site
176299007762	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
176299007763	RNA binding site [nucleotide binding]; other site
176299007764	Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269
176299007765	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
176299007766	motif 1; other site
176299007767	dimer interface [polypeptide binding]; other site
176299007768	active site
176299007769	motif 2; other site
176299007770	motif 3; other site
176299007771	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
176299007772	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299007773	FeS/SAM binding site; other site
176299007774	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
176299007775	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299007776	AsnC family; Region: AsnC_trans_reg; pfam01037
176299007777	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299007778	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299007779	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
176299007780	dimerization interface [polypeptide binding]; other site
176299007781	substrate binding pocket [chemical binding]; other site
176299007782	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299007783	FAD dependent oxidoreductase; Region: DAO; pfam01266
176299007784	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299007785	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299007786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007787	dimer interface [polypeptide binding]; other site
176299007788	conserved gate region; other site
176299007789	putative PBP binding loops; other site
176299007790	ABC-ATPase subunit interface; other site
176299007791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299007792	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
176299007793	Walker A/P-loop; other site
176299007794	ATP binding site [chemical binding]; other site
176299007795	Q-loop/lid; other site
176299007796	ABC transporter signature motif; other site
176299007797	Walker B; other site
176299007798	D-loop; other site
176299007799	H-loop/switch region; other site
176299007800	TOBE domain; Region: TOBE; cl01440
176299007801	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
176299007802	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
176299007803	putative active site pocket [active]
176299007804	cleavage site
176299007805	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
176299007806	ThiS interaction site; other site
176299007807	putative active site [active]
176299007808	tetramer interface [polypeptide binding]; other site
176299007809	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
176299007810	thiS-thiF/thiG interaction site; other site
176299007811	FAD dependent oxidoreductase; Region: DAO; pfam01266
176299007812	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299007813	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
176299007814	ThiC-associated domain; Region: ThiC-associated; pfam13667
176299007815	ThiC family; Region: ThiC; pfam01964
176299007816	acyl carrier protein; Provisional; Region: PRK07081
176299007817	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299007818	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
176299007819	active site
176299007820	Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670
176299007821	dimer interface [polypeptide binding]; other site
176299007822	motif 1; other site
176299007823	active site
176299007824	motif 2; other site
176299007825	motif 3; other site
176299007826	Domain of unknown function (DUF1839); Region: DUF1839; pfam08893
176299007827	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
176299007828	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
176299007829	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299007830	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299007831	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
176299007832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299007833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299007834	Walker A/P-loop; other site
176299007835	ATP binding site [chemical binding]; other site
176299007836	Q-loop/lid; other site
176299007837	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
176299007838	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299007839	ABC transporter signature motif; other site
176299007840	Walker B; other site
176299007841	D-loop; other site
176299007842	H-loop/switch region; other site
176299007843	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299007844	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299007845	ligand binding site [chemical binding]; other site
176299007846	flexible hinge region; other site
176299007847	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
176299007848	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299007849	catalytic loop [active]
176299007850	iron binding site [ion binding]; other site
176299007851	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
176299007852	cyclase homology domain; Region: CHD; cd07302
176299007853	nucleotidyl binding site; other site
176299007854	metal binding site [ion binding]; metal-binding site
176299007855	dimer interface [polypeptide binding]; other site
176299007856	S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692
176299007857	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
176299007858	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
176299007859	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
176299007860	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
176299007861	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299007862	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
176299007863	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928
176299007864	NodB motif; other site
176299007865	putative active site [active]
176299007866	putative catalytic site [active]
176299007867	putative Zn binding site [ion binding]; other site
176299007868	Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774
176299007869	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; cl19952
176299007870	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299007871	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299007872	Walker A/P-loop; other site
176299007873	ATP binding site [chemical binding]; other site
176299007874	Q-loop/lid; other site
176299007875	ABC transporter signature motif; other site
176299007876	Walker B; other site
176299007877	D-loop; other site
176299007878	H-loop/switch region; other site
176299007879	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299007880	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299007881	Walker A/P-loop; other site
176299007882	ATP binding site [chemical binding]; other site
176299007883	Q-loop/lid; other site
176299007884	ABC transporter signature motif; other site
176299007885	Walker B; other site
176299007886	D-loop; other site
176299007887	H-loop/switch region; other site
176299007888	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299007889	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299007890	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
176299007891	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299007892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007893	dimer interface [polypeptide binding]; other site
176299007894	conserved gate region; other site
176299007895	putative PBP binding loops; other site
176299007896	ABC-ATPase subunit interface; other site
176299007897	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299007898	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
176299007899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007900	dimer interface [polypeptide binding]; other site
176299007901	conserved gate region; other site
176299007902	putative PBP binding loops; other site
176299007903	ABC-ATPase subunit interface; other site
176299007904	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
176299007905	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139
176299007906	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
176299007907	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299007908	putative ADP-binding pocket [chemical binding]; other site
176299007909	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
176299007910	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
176299007911	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
176299007912	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299007913	sugar efflux transporter; Region: 2A0120; TIGR00899
176299007914	putative substrate translocation pore; other site
176299007915	Uncharacterized conserved protein [Function unknown]; Region: COG5476
176299007916	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
176299007917	MlrC C-terminus; Region: MlrC_C; pfam07171
176299007918	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
176299007919	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741
176299007920	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
176299007921	active site
176299007922	short chain dehydrogenase; Provisional; Region: PRK07074
176299007923	classical (c) SDRs; Region: SDR_c; cd05233
176299007924	NAD(P) binding site [chemical binding]; other site
176299007925	active site
176299007926	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
176299007927	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
176299007928	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
176299007929	putative active site [active]
176299007930	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
176299007931	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299007932	Walker A/P-loop; other site
176299007933	ATP binding site [chemical binding]; other site
176299007934	Q-loop/lid; other site
176299007935	ABC transporter signature motif; other site
176299007936	Walker B; other site
176299007937	D-loop; other site
176299007938	H-loop/switch region; other site
176299007939	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299007940	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
176299007941	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299007942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007943	dimer interface [polypeptide binding]; other site
176299007944	conserved gate region; other site
176299007945	ABC-ATPase subunit interface; other site
176299007946	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299007947	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299007948	dimer interface [polypeptide binding]; other site
176299007949	conserved gate region; other site
176299007950	putative PBP binding loops; other site
176299007951	ABC-ATPase subunit interface; other site
176299007952	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299007953	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299007954	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299007955	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
176299007956	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299007957	DNA-binding site [nucleotide binding]; DNA binding site
176299007958	UTRA domain; Region: UTRA; pfam07702
176299007959	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
176299007960	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
176299007961	dimer interface [polypeptide binding]; other site
176299007962	active site
176299007963	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
176299007964	dimer interface [polypeptide binding]; other site
176299007965	active site
176299007966	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
176299007967	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
176299007968	active site
176299007969	dimer interface [polypeptide binding]; other site
176299007970	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299007971	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
176299007972	Glucokinase; Region: Glucokinase; cl17310
176299007973	nucleotide binding site [chemical binding]; other site
176299007974	hypothetical protein; Provisional; Region: PRK06185
176299007975	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299007976	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
176299007977	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
176299007978	active site
176299007979	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
176299007980	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
176299007981	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
176299007982	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
176299007983	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
176299007984	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
176299007985	substrate-cofactor binding pocket; other site
176299007986	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299007987	catalytic residue [active]
176299007988	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
176299007989	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
176299007990	Surface antigen; Region: Bac_surface_Ag; pfam01103
176299007991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
176299007992	Family of unknown function (DUF490); Region: DUF490; pfam04357
176299007993	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
176299007994	putative CheA interaction surface; other site
176299007995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299007996	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299007997	putative active site [active]
176299007998	heme pocket [chemical binding]; other site
176299007999	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299008000	putative active site [active]
176299008001	heme pocket [chemical binding]; other site
176299008002	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299008003	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299008004	dimer interface [polypeptide binding]; other site
176299008005	putative CheW interface [polypeptide binding]; other site
176299008006	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
176299008007	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
176299008008	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
176299008009	gamma subunit interface [polypeptide binding]; other site
176299008010	epsilon subunit interface [polypeptide binding]; other site
176299008011	LBP interface [polypeptide binding]; other site
176299008012	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
176299008013	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
176299008014	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
176299008015	alpha subunit interaction interface [polypeptide binding]; other site
176299008016	Walker A motif; other site
176299008017	ATP binding site [chemical binding]; other site
176299008018	Walker B motif; other site
176299008019	inhibitor binding site; inhibition site
176299008020	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
176299008021	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
176299008022	core domain interface [polypeptide binding]; other site
176299008023	delta subunit interface [polypeptide binding]; other site
176299008024	epsilon subunit interface [polypeptide binding]; other site
176299008025	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
176299008026	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
176299008027	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
176299008028	beta subunit interaction interface [polypeptide binding]; other site
176299008029	Walker A motif; other site
176299008030	ATP binding site [chemical binding]; other site
176299008031	Walker B motif; other site
176299008032	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
176299008033	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
176299008034	primosome assembly protein PriA; Validated; Region: PRK05580
176299008035	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299008036	ATP binding site [chemical binding]; other site
176299008037	putative Mg++ binding site [ion binding]; other site
176299008038	helicase superfamily c-terminal domain; Region: HELICc; smart00490
176299008039	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
176299008040	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
176299008041	active site
176299008042	DNA binding site [nucleotide binding]
176299008043	Int/Topo IB signature motif; other site
176299008044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735
176299008045	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
176299008046	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
176299008047	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
176299008048	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299008049	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299008050	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
176299008051	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299008052	Predicted membrane protein [Function unknown]; Region: COG3686
176299008053	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
176299008054	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
176299008055	E3 interaction surface; other site
176299008056	lipoyl attachment site [posttranslational modification]; other site
176299008057	e3 binding domain; Region: E3_binding; pfam02817
176299008058	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
176299008059	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
176299008060	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
176299008061	TPP-binding site [chemical binding]; other site
176299008062	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
176299008063	dimer interface [polypeptide binding]; other site
176299008064	PYR/PP interface [polypeptide binding]; other site
176299008065	TPP binding site [chemical binding]; other site
176299008066	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
176299008067	CoA binding domain; Region: CoA_binding; smart00881
176299008068	CoA-ligase; Region: Ligase_CoA; pfam00549
176299008069	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
176299008070	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
176299008071	CoA-ligase; Region: Ligase_CoA; pfam00549
176299008072	malate dehydrogenase; Reviewed; Region: PRK06223
176299008073	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
176299008074	NAD(P) binding site [chemical binding]; other site
176299008075	dimer interface [polypeptide binding]; other site
176299008076	tetramer (dimer of dimers) interface [polypeptide binding]; other site
176299008077	substrate binding site [chemical binding]; other site
176299008078	Predicted ATPase [General function prediction only]; Region: COG1485
176299008079	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
176299008080	Walker B; other site
176299008081	D-loop; other site
176299008082	H-loop/switch region; other site
176299008083	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
176299008084	Protease inhibitor Inh; Region: Inh; pfam02974
176299008085	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
176299008086	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
176299008087	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299008088	catalytic loop [active]
176299008089	iron binding site [ion binding]; other site
176299008090	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
176299008091	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
176299008092	L-aspartate oxidase; Provisional; Region: PRK06175
176299008093	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
176299008094	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
176299008095	putative SdhC subunit interface [polypeptide binding]; other site
176299008096	putative proximal heme binding site [chemical binding]; other site
176299008097	putative Iron-sulfur protein interface [polypeptide binding]; other site
176299008098	putative proximal quinone binding site; other site
176299008099	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
176299008100	Iron-sulfur protein interface; other site
176299008101	proximal quinone binding site [chemical binding]; other site
176299008102	SdhD (CybS) interface [polypeptide binding]; other site
176299008103	proximal heme binding site [chemical binding]; other site
176299008104	Predicted methyltransferase [General function prediction only]; Region: COG3897
176299008105	Uncharacterized conserved protein [Function unknown]; Region: COG2947
176299008106	YciI-like protein; Reviewed; Region: PRK12865
176299008107	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
176299008108	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
176299008109	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
176299008110	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
176299008111	UGMP family protein; Validated; Region: PRK09604
176299008112	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
176299008113	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
176299008114	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
176299008115	domain interfaces; other site
176299008116	active site
176299008117	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
176299008118	active site
176299008119	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
176299008120	BRE1 E3 ubiquitin ligase; Region: BRE1; pfam08647
176299008121	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
176299008122	HemY protein N-terminus; Region: HemY_N; pfam07219
176299008123	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
176299008124	putative metal binding site [ion binding]; other site
176299008125	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
176299008126	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
176299008127	catalytic triad [active]
176299008128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299008129	H+ Antiporter protein; Region: 2A0121; TIGR00900
176299008130	putative substrate translocation pore; other site
176299008131	hypothetical protein; Validated; Region: PRK01310
176299008132	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
176299008133	dimer interface [polypeptide binding]; other site
176299008134	substrate binding site [chemical binding]; other site
176299008135	metal binding sites [ion binding]; metal-binding site
176299008136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299008137	Coenzyme A binding pocket [chemical binding]; other site
176299008138	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
176299008139	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
176299008140	G1 box; other site
176299008141	putative GEF interaction site [polypeptide binding]; other site
176299008142	GTP/Mg2+ binding site [chemical binding]; other site
176299008143	Switch I region; other site
176299008144	G2 box; other site
176299008145	G3 box; other site
176299008146	Switch II region; other site
176299008147	G4 box; other site
176299008148	G5 box; other site
176299008149	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
176299008150	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
176299008151	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
176299008152	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
176299008153	active site
176299008154	Zn binding site [ion binding]; other site
176299008155	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299008156	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299008157	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
176299008158	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299008159	putative substrate translocation pore; other site
176299008160	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
176299008161	ANP binding site [chemical binding]; other site
176299008162	Substrate Binding Site II [chemical binding]; other site
176299008163	Substrate Binding Site I [chemical binding]; other site
176299008164	hypothetical protein; Provisional; Region: PRK06194
176299008165	classical (c) SDRs; Region: SDR_c; cd05233
176299008166	NAD(P) binding site [chemical binding]; other site
176299008167	active site
176299008168	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299008169	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
176299008170	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299008171	Walker A/P-loop; other site
176299008172	ATP binding site [chemical binding]; other site
176299008173	Q-loop/lid; other site
176299008174	ABC transporter signature motif; other site
176299008175	Walker B; other site
176299008176	D-loop; other site
176299008177	H-loop/switch region; other site
176299008178	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
176299008179	TM-ABC transporter signature motif; other site
176299008180	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
176299008181	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299008182	zinc binding site [ion binding]; other site
176299008183	putative ligand binding site [chemical binding]; other site
176299008184	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
176299008185	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299008186	FeS/SAM binding site; other site
176299008187	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
176299008188	Uncharacterized conserved protein [Function unknown]; Region: COG3339
176299008189	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
176299008190	aromatic arch; other site
176299008191	DCoH dimer interaction site [polypeptide binding]; other site
176299008192	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
176299008193	DCoH tetramer interaction site [polypeptide binding]; other site
176299008194	substrate binding site [chemical binding]; other site
176299008195	Low molecular weight phosphatase family; Region: LMWPc; cd00115
176299008196	active site
176299008197	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
176299008198	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
176299008199	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
176299008200	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
176299008201	active site
176299008202	catalytic triad [active]
176299008203	oxyanion hole [active]
176299008204	switch loop; other site
176299008205	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
176299008206	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
176299008207	Walker A/P-loop; other site
176299008208	ATP binding site [chemical binding]; other site
176299008209	Q-loop/lid; other site
176299008210	ABC transporter signature motif; other site
176299008211	Walker B; other site
176299008212	D-loop; other site
176299008213	H-loop/switch region; other site
176299008214	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
176299008215	FtsX-like permease family; Region: FtsX; pfam02687
176299008216	FtsX-like permease family; Region: FtsX; pfam02687
176299008217	ybhL leader; predicted by RFAM
176299008218	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
176299008219	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
176299008220	Uncharacterized secreted protein [Function unknown]; Region: COG5429
176299008221	aconitate hydratase; Validated; Region: PRK09277
176299008222	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
176299008223	substrate binding site [chemical binding]; other site
176299008224	ligand binding site [chemical binding]; other site
176299008225	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
176299008226	substrate binding site [chemical binding]; other site
176299008227	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
176299008228	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
176299008229	Walker A/P-loop; other site
176299008230	ATP binding site [chemical binding]; other site
176299008231	Q-loop/lid; other site
176299008232	ABC transporter signature motif; other site
176299008233	Walker B; other site
176299008234	D-loop; other site
176299008235	H-loop/switch region; other site
176299008236	heme exporter protein CcmB; Region: ccmB; TIGR01190
176299008237	heme exporter protein CcmC; Region: ccmC; TIGR01191
176299008238	Heme exporter protein D (CcmD); Region: CcmD; pfam04995
176299008239	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
176299008240	catalytic residues [active]
176299008241	central insert; other site
176299008242	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299008243	metal binding site [ion binding]; metal-binding site
176299008244	active site
176299008245	I-site; other site
176299008246	hypothetical protein; Provisional; Region: PRK00944
176299008247	intracellular septation protein A; Reviewed; Region: PRK00259
176299008248	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
176299008249	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
176299008250	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
176299008251	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
176299008252	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
176299008253	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299008254	FeS/SAM binding site; other site
176299008255	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
176299008256	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
176299008257	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
176299008258	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
176299008259	signal recognition particle protein; Provisional; Region: PRK10867
176299008260	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
176299008261	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
176299008262	P loop; other site
176299008263	GTP binding site [chemical binding]; other site
176299008264	Signal peptide binding domain; Region: SRP_SPB; pfam02978
176299008265	chorismate mutase; Provisional; Region: PRK09239
176299008266	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
176299008267	RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806
176299008268	RimM N-terminal domain; Region: RimM; pfam01782
176299008269	PRC-barrel domain; Region: PRC; pfam05239
176299008270	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
176299008271	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
176299008272	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
176299008273	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
176299008274	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299008275	Walker A/P-loop; other site
176299008276	ATP binding site [chemical binding]; other site
176299008277	Q-loop/lid; other site
176299008278	ABC transporter signature motif; other site
176299008279	Walker B; other site
176299008280	D-loop; other site
176299008281	H-loop/switch region; other site
176299008282	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
176299008283	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299008284	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299008285	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
176299008286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299008287	putative substrate translocation pore; other site
176299008288	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
176299008289	substrate binding site [chemical binding]; other site
176299008290	ligand binding site [chemical binding]; other site
176299008291	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
176299008292	Peptidase family M48; Region: Peptidase_M48; cl12018
176299008293	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
176299008294	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
176299008295	ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298
176299008296	Walker A/P-loop; other site
176299008297	ATP binding site [chemical binding]; other site
176299008298	Q-loop/lid; other site
176299008299	ABC transporter signature motif; other site
176299008300	Walker B; other site
176299008301	D-loop; other site
176299008302	H-loop/switch region; other site
176299008303	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
176299008304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008305	dimer interface [polypeptide binding]; other site
176299008306	conserved gate region; other site
176299008307	putative PBP binding loops; other site
176299008308	ABC-ATPase subunit interface; other site
176299008309	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
176299008310	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
176299008311	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
176299008312	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
176299008313	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
176299008314	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299008315	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299008316	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
176299008317	Thiamine pyrophosphokinase; Region: TPK; cd07995
176299008318	active site
176299008319	dimerization interface [polypeptide binding]; other site
176299008320	thiamine binding site [chemical binding]; other site
176299008321	SAM riboswitch (alpha-proteobacteria); predicted by RFAM
176299008322	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
176299008323	proposed active site lysine [active]
176299008324	conserved cys residue [active]
176299008325	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
176299008326	active site
176299008327	catalytic residues [active]
176299008328	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
176299008329	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
176299008330	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
176299008331	substrate binding pocket [chemical binding]; other site
176299008332	chain length determination region; other site
176299008333	active site lid residues [active]
176299008334	substrate-Mg2+ binding site; other site
176299008335	catalytic residues [active]
176299008336	aspartate-rich region 1; other site
176299008337	aspartate-rich region 2; other site
176299008338	putative outer membrane lipoprotein; Provisional; Region: PRK10510
176299008339	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
176299008340	ligand binding site [chemical binding]; other site
176299008341	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
176299008342	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612
176299008343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299008344	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299008345	putative substrate translocation pore; other site
176299008346	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
176299008347	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
176299008348	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
176299008349	Pyruvate carboxylase [Energy production and conversion]; Region: PycA; COG1038
176299008350	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299008351	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299008352	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
176299008353	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
176299008354	active site
176299008355	catalytic residues [active]
176299008356	metal binding site [ion binding]; metal-binding site
176299008357	homodimer binding site [polypeptide binding]; other site
176299008358	Conserved carboxylase domain; Region: PYC_OADA; pfam02436
176299008359	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
176299008360	carboxyltransferase (CT) interaction site; other site
176299008361	biotinylation site [posttranslational modification]; other site
176299008362	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
176299008363	Autoinducer binding domain; Region: Autoind_bind; pfam03472
176299008364	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299008365	DNA binding residues [nucleotide binding]
176299008366	dimerization interface [polypeptide binding]; other site
176299008367	glucan exporter ATP-binding protein; Region: chvA; TIGR01192
176299008368	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299008369	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
176299008370	Walker A/P-loop; other site
176299008371	ATP binding site [chemical binding]; other site
176299008372	Q-loop/lid; other site
176299008373	ABC transporter signature motif; other site
176299008374	Walker B; other site
176299008375	D-loop; other site
176299008376	H-loop/switch region; other site
176299008377	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299008378	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
176299008379	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
176299008380	Putative glucoamylase; Region: Glycoamylase; pfam10091
176299008381	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
176299008382	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
176299008383	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
176299008384	Protein of unknown function, DUF608; Region: DUF608; pfam04685
176299008385	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
176299008386	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
176299008387	metal binding site [ion binding]; metal-binding site
176299008388	putative dimer interface [polypeptide binding]; other site
176299008389	hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156
176299008390	FAD dependent oxidoreductase; Region: DAO; pfam01266
176299008391	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
176299008392	tetramer interface [polypeptide binding]; other site
176299008393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299008394	catalytic residue [active]
176299008395	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
176299008396	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
176299008397	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
176299008398	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
176299008399	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299008400	Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238
176299008401	putative NAD(P) binding site [chemical binding]; other site
176299008402	active site
176299008403	putative substrate binding site [chemical binding]; other site
176299008404	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
176299008405	FAD binding domain; Region: FAD_binding_4; pfam01565
176299008406	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
176299008407	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
176299008408	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299008409	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299008410	DNA-binding site [nucleotide binding]; DNA binding site
176299008411	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299008412	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
176299008413	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
176299008414	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
176299008415	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
176299008416	DctM-like transporters; Region: DctM; pfam06808
176299008417	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
176299008418	acetyl-CoA synthetase; Provisional; Region: PRK00174
176299008419	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
176299008420	active site
176299008421	CoA binding site [chemical binding]; other site
176299008422	acyl-activating enzyme (AAE) consensus motif; other site
176299008423	AMP binding site [chemical binding]; other site
176299008424	acetate binding site [chemical binding]; other site
176299008425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820
176299008426	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
176299008427	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299008428	catalytic residue [active]
176299008429	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
176299008430	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
176299008431	HIGH motif; other site
176299008432	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
176299008433	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
176299008434	active site
176299008435	KMSKS motif; other site
176299008436	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
176299008437	tRNA binding surface [nucleotide binding]; other site
176299008438	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5468
176299008439	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
176299008440	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
176299008441	Ferredoxin [Energy production and conversion]; Region: COG1146
176299008442	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
176299008443	4Fe-4S binding domain; Region: Fer4; pfam00037
176299008444	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
176299008445	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
176299008446	RNA binding surface [nucleotide binding]; other site
176299008447	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299008448	ATP binding site [chemical binding]; other site
176299008449	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
176299008450	putative Mg++ binding site [ion binding]; other site
176299008451	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299008452	nucleotide binding region [chemical binding]; other site
176299008453	ATP-binding site [chemical binding]; other site
176299008454	Pre-mRNA-splicing factor 38-associated hydrophilic C-term; Region: PRP38_assoc; pfam12871
176299008455	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
176299008456	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
176299008457	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
176299008458	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
176299008459	active site
176299008460	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
176299008461	catalytic triad [active]
176299008462	dimer interface [polypeptide binding]; other site
176299008463	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
176299008464	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
176299008465	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
176299008466	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
176299008467	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
176299008468	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
176299008469	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
176299008470	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
176299008471	putative catalytic site [active]
176299008472	putative phosphate binding site [ion binding]; other site
176299008473	active site
176299008474	metal binding site A [ion binding]; metal-binding site
176299008475	DNA binding site [nucleotide binding]
176299008476	putative AP binding site [nucleotide binding]; other site
176299008477	putative metal binding site B [ion binding]; other site
176299008478	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299008479	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299008480	ligand binding site [chemical binding]; other site
176299008481	flexible hinge region; other site
176299008482	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299008483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299008484	active site
176299008485	phosphorylation site [posttranslational modification]
176299008486	intermolecular recognition site; other site
176299008487	dimerization interface [polypeptide binding]; other site
176299008488	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299008489	DNA binding site [nucleotide binding]
176299008490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
176299008491	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
176299008492	NAD-specific glutamate dehydrogenase [Amino acid transport and metabolism]; Region: COG2902
176299008493	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
176299008494	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
176299008495	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
176299008496	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
176299008497	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
176299008498	putative acyltransferase; Provisional; Region: PRK05790
176299008499	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
176299008500	dimer interface [polypeptide binding]; other site
176299008501	active site
176299008502	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
176299008503	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
176299008504	NAD(P) binding site [chemical binding]; other site
176299008505	homotetramer interface [polypeptide binding]; other site
176299008506	homodimer interface [polypeptide binding]; other site
176299008507	active site
176299008508	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
176299008509	Ferritin-like domain; Region: Ferritin; pfam00210
176299008510	heme binding site [chemical binding]; other site
176299008511	ferroxidase pore; other site
176299008512	ferroxidase diiron center [ion binding]; other site
176299008513	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
176299008514	putative active site [active]
176299008515	Ap4A binding site [chemical binding]; other site
176299008516	nudix motif; other site
176299008517	putative metal binding site [ion binding]; other site
176299008518	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
176299008519	NodB motif; other site
176299008520	putative active site [active]
176299008521	putative catalytic site [active]
176299008522	Zn binding site [ion binding]; other site
176299008523	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
176299008524	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
176299008525	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
176299008526	protein binding site [polypeptide binding]; other site
176299008527	Catalytic dyad [active]
176299008528	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
176299008529	Peptidase family M23; Region: Peptidase_M23; pfam01551
176299008530	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
176299008531	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
176299008532	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
176299008533	active site
176299008534	(T/H)XGH motif; other site
176299008535	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
176299008536	putative catalytic cysteine [active]
176299008537	gamma-glutamyl kinase; Provisional; Region: PRK05429
176299008538	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
176299008539	nucleotide binding site [chemical binding]; other site
176299008540	homotetrameric interface [polypeptide binding]; other site
176299008541	putative phosphate binding site [ion binding]; other site
176299008542	putative allosteric binding site; other site
176299008543	PUA domain; Region: PUA; pfam01472
176299008544	GTPase CgtA; Reviewed; Region: obgE; PRK12299
176299008545	GTP1/OBG; Region: GTP1_OBG; pfam01018
176299008546	Obg GTPase; Region: Obg; cd01898
176299008547	G1 box; other site
176299008548	GTP/Mg2+ binding site [chemical binding]; other site
176299008549	Switch I region; other site
176299008550	G2 box; other site
176299008551	G3 box; other site
176299008552	Switch II region; other site
176299008553	G4 box; other site
176299008554	G5 box; other site
176299008555	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299008556	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299008557	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299008558	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299008559	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
176299008560	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
176299008561	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
176299008562	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
176299008563	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
176299008564	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
176299008565	substrate binding site [chemical binding]; other site
176299008566	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
176299008567	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
176299008568	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
176299008569	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
176299008570	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299008571	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
176299008572	conserved cys residue [active]
176299008573	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
176299008574	active site
176299008575	SAM binding site [chemical binding]; other site
176299008576	homodimer interface [polypeptide binding]; other site
176299008577	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
176299008578	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
176299008579	active site
176299008580	SAM binding site [chemical binding]; other site
176299008581	homodimer interface [polypeptide binding]; other site
176299008582	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
176299008583	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
176299008584	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
176299008585	active site
176299008586	putative homodimer interface [polypeptide binding]; other site
176299008587	SAM binding site [chemical binding]; other site
176299008588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299008589	S-adenosylmethionine binding site [chemical binding]; other site
176299008590	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
176299008591	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
176299008592	active site
176299008593	SAM binding site [chemical binding]; other site
176299008594	homodimer interface [polypeptide binding]; other site
176299008595	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
176299008596	active site
176299008597	SAM binding site [chemical binding]; other site
176299008598	homodimer interface [polypeptide binding]; other site
176299008599	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
176299008600	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
176299008601	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
176299008602	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
176299008603	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
176299008604	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
176299008605	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
176299008606	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
176299008607	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
176299008608	dimer interface [polypeptide binding]; other site
176299008609	[2Fe-2S] cluster binding site [ion binding]; other site
176299008610	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
176299008611	cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986
176299008612	cobyric acid synthase; Provisional; Region: PRK00784
176299008613	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299008614	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
176299008615	catalytic triad [active]
176299008616	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
176299008617	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
176299008618	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299008619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299008620	homodimer interface [polypeptide binding]; other site
176299008621	catalytic residue [active]
176299008622	Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324
176299008623	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299008624	putative active site pocket [active]
176299008625	metal binding site [ion binding]; metal-binding site
176299008626	Uncharacterized conserved protein [Function unknown]; Region: COG3254
176299008627	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
176299008628	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
176299008629	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
176299008630	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
176299008631	putative NAD(P) binding site [chemical binding]; other site
176299008632	catalytic Zn binding site [ion binding]; other site
176299008633	structural Zn binding site [ion binding]; other site
176299008634	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
176299008635	active site
176299008636	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299008637	active site
176299008638	catalytic tetrad [active]
176299008639	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299008640	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
176299008641	putative ligand binding site [chemical binding]; other site
176299008642	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299008643	TM-ABC transporter signature motif; other site
176299008644	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299008645	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299008646	Walker A/P-loop; other site
176299008647	ATP binding site [chemical binding]; other site
176299008648	Q-loop/lid; other site
176299008649	ABC transporter signature motif; other site
176299008650	Walker B; other site
176299008651	D-loop; other site
176299008652	H-loop/switch region; other site
176299008653	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299008654	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299008655	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299008656	DNA-binding site [nucleotide binding]; DNA binding site
176299008657	FCD domain; Region: FCD; pfam07729
176299008658	galactarate dehydratase; Region: galactar-dH20; TIGR03248
176299008659	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
176299008660	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
176299008661	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
176299008662	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
176299008663	purine monophosphate binding site [chemical binding]; other site
176299008664	dimer interface [polypeptide binding]; other site
176299008665	putative catalytic residues [active]
176299008666	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
176299008667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5360
176299008668	NusB family; Region: NusB; pfam01029
176299008669	putative RNA binding site [nucleotide binding]; other site
176299008670	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
176299008671	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299008672	S-adenosylmethionine binding site [chemical binding]; other site
176299008673	heat shock protein HtpX; Provisional; Region: PRK01345
176299008674	M48 family peptidase; Provisional; Region: PRK03001
176299008675	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
176299008676	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
176299008677	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
176299008678	ParB-like nuclease domain; Region: ParBc; pfam02195
176299008679	KorB domain; Region: KorB; pfam08535
176299008680	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
176299008681	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
176299008682	P-loop; other site
176299008683	Magnesium ion binding site [ion binding]; other site
176299008684	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
176299008685	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
176299008686	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
176299008687	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
176299008688	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
176299008689	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
176299008690	trmE is a tRNA modification GTPase; Region: trmE; cd04164
176299008691	G1 box; other site
176299008692	GTP/Mg2+ binding site [chemical binding]; other site
176299008693	Switch I region; other site
176299008694	G2 box; other site
176299008695	Switch II region; other site
176299008696	G3 box; other site
176299008697	G4 box; other site
176299008698	G5 box; other site
176299008699	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
176299008700	transcription termination factor Rho; Provisional; Region: rho; PRK09376
176299008701	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
176299008702	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
176299008703	RNA binding site [nucleotide binding]; other site
176299008704	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
176299008705	multimer interface [polypeptide binding]; other site
176299008706	Walker A motif; other site
176299008707	ATP binding site [chemical binding]; other site
176299008708	Walker B motif; other site
176299008709	Predicted membrane protein [Function unknown]; Region: COG1981
176299008710	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
176299008711	substrate binding site [chemical binding]; other site
176299008712	active site
176299008713	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
176299008714	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
176299008715	active site
176299008716	O-Antigen ligase; Region: Wzy_C; pfam04932
176299008717	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
176299008718	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
176299008719	putative hydrophobic ligand binding site [chemical binding]; other site
176299008720	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
176299008721	putative hydrophobic ligand binding site [chemical binding]; other site
176299008722	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299008723	dimerization interface [polypeptide binding]; other site
176299008724	putative DNA binding site [nucleotide binding]; other site
176299008725	putative Zn2+ binding site [ion binding]; other site
176299008726	Protein of unknown function (DUF3396); Region: DUF3396; pfam11876
176299008727	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
176299008728	putative active site [active]
176299008729	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
176299008730	AAA domain; Region: AAA_33; pfam13671
176299008731	AAA domain; Region: AAA_18; pfam13238
176299008732	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
176299008733	catalytic core [active]
176299008734	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
176299008735	Predicted ester cyclase [General function prediction only]; Region: COG5485
176299008736	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299008737	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299008738	DNA-binding site [nucleotide binding]; DNA binding site
176299008739	FCD domain; Region: FCD; pfam07729
176299008740	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299008741	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299008742	Walker A/P-loop; other site
176299008743	ATP binding site [chemical binding]; other site
176299008744	Q-loop/lid; other site
176299008745	ABC transporter signature motif; other site
176299008746	Walker B; other site
176299008747	D-loop; other site
176299008748	H-loop/switch region; other site
176299008749	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299008750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008751	dimer interface [polypeptide binding]; other site
176299008752	conserved gate region; other site
176299008753	putative PBP binding loops; other site
176299008754	ABC-ATPase subunit interface; other site
176299008755	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299008756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008757	dimer interface [polypeptide binding]; other site
176299008758	conserved gate region; other site
176299008759	ABC-ATPase subunit interface; other site
176299008760	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299008761	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299008762	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
176299008763	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299008764	classical (c) SDRs; Region: SDR_c; cd05233
176299008765	NAD(P) binding site [chemical binding]; other site
176299008766	active site
176299008767	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
176299008768	active site
176299008769	oxyanion hole [active]
176299008770	catalytic triad [active]
176299008771	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
176299008772	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299008773	putative ligand binding site [chemical binding]; other site
176299008774	putative NAD binding site [chemical binding]; other site
176299008775	catalytic site [active]
176299008776	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299008777	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299008778	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299008779	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
176299008780	active site
176299008781	tetramer interface [polypeptide binding]; other site
176299008782	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
176299008783	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
176299008784	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299008785	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299008786	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299008787	DNA binding residues [nucleotide binding]
176299008788	dimerization interface [polypeptide binding]; other site
176299008789	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299008790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008791	dimer interface [polypeptide binding]; other site
176299008792	conserved gate region; other site
176299008793	putative PBP binding loops; other site
176299008794	ABC-ATPase subunit interface; other site
176299008795	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299008796	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299008797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008798	dimer interface [polypeptide binding]; other site
176299008799	conserved gate region; other site
176299008800	putative PBP binding loops; other site
176299008801	ABC-ATPase subunit interface; other site
176299008802	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299008803	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299008804	Walker A/P-loop; other site
176299008805	ATP binding site [chemical binding]; other site
176299008806	Q-loop/lid; other site
176299008807	ABC transporter signature motif; other site
176299008808	Walker B; other site
176299008809	D-loop; other site
176299008810	H-loop/switch region; other site
176299008811	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299008812	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299008813	Walker A/P-loop; other site
176299008814	ATP binding site [chemical binding]; other site
176299008815	Q-loop/lid; other site
176299008816	ABC transporter signature motif; other site
176299008817	Walker B; other site
176299008818	D-loop; other site
176299008819	H-loop/switch region; other site
176299008820	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299008821	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
176299008822	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
176299008823	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
176299008824	Uncharacterized conserved protein [Function unknown]; Region: COG3535
176299008825	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299008826	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
176299008827	Uncharacterized conserved protein [Function unknown]; Region: COG3535
176299008828	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
176299008829	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
176299008830	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
176299008831	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
176299008832	catalytic nucleophile [active]
176299008833	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
176299008834	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299008835	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299008836	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299008837	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299008838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008839	dimer interface [polypeptide binding]; other site
176299008840	conserved gate region; other site
176299008841	putative PBP binding loops; other site
176299008842	ABC-ATPase subunit interface; other site
176299008843	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299008844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008845	dimer interface [polypeptide binding]; other site
176299008846	conserved gate region; other site
176299008847	putative PBP binding loops; other site
176299008848	ABC-ATPase subunit interface; other site
176299008849	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299008850	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
176299008851	peptide binding site [polypeptide binding]; other site
176299008852	dimer interface [polypeptide binding]; other site
176299008853	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299008854	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299008855	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
176299008856	HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
176299008857	putative NAD(P) binding site [chemical binding]; other site
176299008858	active site
176299008859	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299008860	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299008861	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299008862	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299008863	Walker A/P-loop; other site
176299008864	ATP binding site [chemical binding]; other site
176299008865	Q-loop/lid; other site
176299008866	ABC transporter signature motif; other site
176299008867	Walker B; other site
176299008868	D-loop; other site
176299008869	H-loop/switch region; other site
176299008870	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299008871	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299008872	Walker A/P-loop; other site
176299008873	ATP binding site [chemical binding]; other site
176299008874	Q-loop/lid; other site
176299008875	ABC transporter signature motif; other site
176299008876	Walker B; other site
176299008877	D-loop; other site
176299008878	H-loop/switch region; other site
176299008879	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299008880	Putative glucoamylase; Region: Glycoamylase; cl19893
176299008881	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
176299008882	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
176299008883	DXD motif; other site
176299008884	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
176299008885	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
176299008886	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
176299008887	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
176299008888	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
176299008889	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
176299008890	FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770
176299008891	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
176299008892	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299008893	metal binding site [ion binding]; metal-binding site
176299008894	active site
176299008895	I-site; other site
176299008896	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299008897	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299008898	DNA binding site [nucleotide binding]
176299008899	domain linker motif; other site
176299008900	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293
176299008901	putative dimerization interface [polypeptide binding]; other site
176299008902	putative ligand binding site [chemical binding]; other site
176299008903	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299008904	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
176299008905	ligand binding site [chemical binding]; other site
176299008906	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
176299008907	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299008908	Walker A/P-loop; other site
176299008909	ATP binding site [chemical binding]; other site
176299008910	Q-loop/lid; other site
176299008911	ABC transporter signature motif; other site
176299008912	Walker B; other site
176299008913	D-loop; other site
176299008914	H-loop/switch region; other site
176299008915	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299008916	TM-ABC transporter signature motif; other site
176299008917	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
176299008918	active site
176299008919	substrate binding pocket [chemical binding]; other site
176299008920	homodimer interaction site [polypeptide binding]; other site
176299008921	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
176299008922	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
176299008923	substrate binding site [chemical binding]; other site
176299008924	dimer interface [polypeptide binding]; other site
176299008925	ATP binding site [chemical binding]; other site
176299008926	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
176299008927	allantoate amidohydrolase; Reviewed; Region: PRK12893
176299008928	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
176299008929	active site
176299008930	metal binding site [ion binding]; metal-binding site
176299008931	dimer interface [polypeptide binding]; other site
176299008932	Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297
176299008933	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
176299008934	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
176299008935	acyl-activating enzyme (AAE) consensus motif; other site
176299008936	AMP binding site [chemical binding]; other site
176299008937	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299008938	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
176299008939	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
176299008940	putative trimer interface [polypeptide binding]; other site
176299008941	putative CoA binding site [chemical binding]; other site
176299008942	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
176299008943	putative trimer interface [polypeptide binding]; other site
176299008944	putative CoA binding site [chemical binding]; other site
176299008945	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
176299008946	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
176299008947	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
176299008948	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299008949	NAD(P) binding site [chemical binding]; other site
176299008950	active site
176299008951	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299008952	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299008953	Sulfate transporter family; Region: Sulfate_transp; cl19250
176299008954	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
176299008955	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
176299008956	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299008957	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299008958	The C-terminal substrate domain of LysR-type transcriptional regulator AmpR that involved in control of the expression of beta-lactamase gene ampC, contains the type 2 periplasmic binding fold; Region: PBP2_AmpR; cd08488
176299008959	putative dimerization interface [polypeptide binding]; other site
176299008960	putative substrate binding pocket [chemical binding]; other site
176299008961	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
176299008962	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
176299008963	Chromate transporter; Region: Chromate_transp; pfam02417
176299008964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
176299008965	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267
176299008966	Predicted integral membrane protein [Function unknown]; Region: COG5612
176299008967	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
176299008968	RNA polymerase sigma factor; Reviewed; Region: PRK05602
176299008969	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299008970	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299008971	DNA binding residues [nucleotide binding]
176299008972	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
176299008973	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299008974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008975	dimer interface [polypeptide binding]; other site
176299008976	conserved gate region; other site
176299008977	putative PBP binding loops; other site
176299008978	ABC-ATPase subunit interface; other site
176299008979	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299008980	dimer interface [polypeptide binding]; other site
176299008981	conserved gate region; other site
176299008982	putative PBP binding loops; other site
176299008983	ABC-ATPase subunit interface; other site
176299008984	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
176299008985	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299008986	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299008987	Walker A/P-loop; other site
176299008988	ATP binding site [chemical binding]; other site
176299008989	Q-loop/lid; other site
176299008990	ABC transporter signature motif; other site
176299008991	Walker B; other site
176299008992	D-loop; other site
176299008993	H-loop/switch region; other site
176299008994	TOBE domain; Region: TOBE_2; pfam08402
176299008995	DNA polymerase III subunit epsilon; Validated; Region: PRK09182
176299008996	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
176299008997	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
176299008998	active site
176299008999	catalytic site [active]
176299009000	substrate binding site [chemical binding]; other site
176299009001	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
176299009002	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299009003	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299009004	catalytic residue [active]
176299009005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299009006	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299009007	putative active site [active]
176299009008	heme pocket [chemical binding]; other site
176299009009	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299009010	putative active site [active]
176299009011	heme pocket [chemical binding]; other site
176299009012	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299009013	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299009014	dimer interface [polypeptide binding]; other site
176299009015	putative CheW interface [polypeptide binding]; other site
176299009016	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
176299009017	dimer interface [polypeptide binding]; other site
176299009018	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009019	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
176299009020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
176299009021	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299009022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009023	dimer interface [polypeptide binding]; other site
176299009024	conserved gate region; other site
176299009025	putative PBP binding loops; other site
176299009026	ABC-ATPase subunit interface; other site
176299009027	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009029	dimer interface [polypeptide binding]; other site
176299009030	conserved gate region; other site
176299009031	putative PBP binding loops; other site
176299009032	ABC-ATPase subunit interface; other site
176299009033	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299009034	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009035	Walker A/P-loop; other site
176299009036	ATP binding site [chemical binding]; other site
176299009037	Q-loop/lid; other site
176299009038	ABC transporter signature motif; other site
176299009039	Walker B; other site
176299009040	D-loop; other site
176299009041	H-loop/switch region; other site
176299009042	TOBE domain; Region: TOBE_2; pfam08402
176299009043	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009045	dimer interface [polypeptide binding]; other site
176299009046	conserved gate region; other site
176299009047	putative PBP binding loops; other site
176299009048	ABC-ATPase subunit interface; other site
176299009049	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299009050	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009051	dimer interface [polypeptide binding]; other site
176299009052	conserved gate region; other site
176299009053	putative PBP binding loops; other site
176299009054	ABC-ATPase subunit interface; other site
176299009055	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009056	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009057	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299009058	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009059	Walker A/P-loop; other site
176299009060	ATP binding site [chemical binding]; other site
176299009061	Q-loop/lid; other site
176299009062	ABC transporter signature motif; other site
176299009063	Walker B; other site
176299009064	D-loop; other site
176299009065	H-loop/switch region; other site
176299009066	TOBE domain; Region: TOBE_2; pfam08402
176299009067	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
176299009068	HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410
176299009069	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
176299009070	Predicted transcriptional regulator [Transcription]; Region: COG4189
176299009071	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299009072	dimerization interface [polypeptide binding]; other site
176299009073	putative DNA binding site [nucleotide binding]; other site
176299009074	putative Zn2+ binding site [ion binding]; other site
176299009075	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009076	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
176299009077	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299009078	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299009079	DNA binding site [nucleotide binding]
176299009080	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
176299009081	ligand binding site [chemical binding]; other site
176299009082	dimerization interface [polypeptide binding]; other site
176299009083	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4289
176299009084	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167
176299009085	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299009086	putative ligand binding site [chemical binding]; other site
176299009087	putative NAD binding site [chemical binding]; other site
176299009088	catalytic site [active]
176299009089	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299009090	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299009091	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299009092	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009093	Walker A/P-loop; other site
176299009094	ATP binding site [chemical binding]; other site
176299009095	Q-loop/lid; other site
176299009096	ABC transporter signature motif; other site
176299009097	Walker B; other site
176299009098	D-loop; other site
176299009099	H-loop/switch region; other site
176299009100	TOBE domain; Region: TOBE_2; pfam08402
176299009101	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009102	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009103	dimer interface [polypeptide binding]; other site
176299009104	conserved gate region; other site
176299009105	putative PBP binding loops; other site
176299009106	ABC-ATPase subunit interface; other site
176299009107	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009109	dimer interface [polypeptide binding]; other site
176299009110	conserved gate region; other site
176299009111	putative PBP binding loops; other site
176299009112	ABC-ATPase subunit interface; other site
176299009113	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009114	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009115	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
176299009116	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299009117	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299009118	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
176299009119	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299009120	Protein of unknown function (DUF993); Region: DUF993; pfam06187
176299009121	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299009122	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299009123	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299009124	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299009125	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299009126	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
176299009127	DNA-binding site [nucleotide binding]; DNA binding site
176299009128	RNA-binding motif; other site
176299009129	Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828
176299009130	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
176299009131	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
176299009132	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
176299009133	Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188
176299009134	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009135	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009136	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299009137	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009138	Walker A/P-loop; other site
176299009139	ATP binding site [chemical binding]; other site
176299009140	Q-loop/lid; other site
176299009141	ABC transporter signature motif; other site
176299009142	Walker B; other site
176299009143	D-loop; other site
176299009144	H-loop/switch region; other site
176299009145	TOBE domain; Region: TOBE_2; pfam08402
176299009146	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009147	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009148	dimer interface [polypeptide binding]; other site
176299009149	conserved gate region; other site
176299009150	putative PBP binding loops; other site
176299009151	ABC-ATPase subunit interface; other site
176299009152	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299009153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009154	dimer interface [polypeptide binding]; other site
176299009155	conserved gate region; other site
176299009156	putative PBP binding loops; other site
176299009157	ABC-ATPase subunit interface; other site
176299009158	Cupin domain; Region: Cupin_2; cl17218
176299009159	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299009160	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299009161	DctM-like transporters; Region: DctM; pfam06808
176299009162	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
176299009163	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
176299009164	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
176299009165	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
176299009166	active site
176299009167	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299009168	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
176299009169	active site pocket [active]
176299009170	5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951
176299009171	putative active site [active]
176299009172	catalytic residue [active]
176299009173	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
176299009174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299009175	NAD(P) binding site [chemical binding]; other site
176299009176	active site
176299009177	5-keto 4-deoxyuronate isomerase [Carbohydrate transport and metabolism]; Region: KduI; COG3717
176299009178	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299009179	short chain dehydrogenase; Region: adh_short; pfam00106
176299009180	NAD(P) binding site [chemical binding]; other site
176299009181	active site
176299009182	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299009183	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299009184	DNA-binding site [nucleotide binding]; DNA binding site
176299009185	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299009186	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
176299009187	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
176299009188	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299009189	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
176299009190	active site
176299009191	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299009192	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299009193	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299009194	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299009195	active site
176299009196	catalytic tetrad [active]
176299009197	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
176299009198	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009199	Walker A/P-loop; other site
176299009200	ATP binding site [chemical binding]; other site
176299009201	Q-loop/lid; other site
176299009202	ABC transporter signature motif; other site
176299009203	Walker B; other site
176299009204	D-loop; other site
176299009205	H-loop/switch region; other site
176299009206	TOBE domain; Region: TOBE_2; pfam08402
176299009207	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009209	dimer interface [polypeptide binding]; other site
176299009210	conserved gate region; other site
176299009211	putative PBP binding loops; other site
176299009212	ABC-ATPase subunit interface; other site
176299009213	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299009214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009215	dimer interface [polypeptide binding]; other site
176299009216	conserved gate region; other site
176299009217	putative PBP binding loops; other site
176299009218	ABC-ATPase subunit interface; other site
176299009219	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009220	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009221	Cupin domain; Region: Cupin_2; cl17218
176299009222	Helix-turn-helix domain; Region: HTH_18; pfam12833
176299009223	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299009224	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
176299009225	Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720
176299009226	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299009227	Helix-turn-helix domain; Region: HTH_18; pfam12833
176299009228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299009229	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299009230	putative substrate translocation pore; other site
176299009231	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299009232	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299009233	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
176299009234	dimerization interface [polypeptide binding]; other site
176299009235	substrate binding pocket [chemical binding]; other site
176299009236	DctM-like transporters; Region: DctM; pfam06808
176299009237	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
176299009238	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
176299009239	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
176299009240	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
176299009241	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
176299009242	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
176299009243	Uncharacterized conserved protein [Function unknown]; Region: COG1359
176299009244	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
176299009245	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
176299009246	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
176299009247	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299009248	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299009249	DNA binding site [nucleotide binding]
176299009250	domain linker motif; other site
176299009251	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
176299009252	dimerization interface [polypeptide binding]; other site
176299009253	ligand binding site [chemical binding]; other site
176299009254	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
176299009255	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
176299009256	putative NAD(P) binding site [chemical binding]; other site
176299009257	catalytic Zn binding site [ion binding]; other site
176299009258	sorbitol dehydrogenase; Provisional; Region: PRK07067
176299009259	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299009260	NAD(P) binding site [chemical binding]; other site
176299009261	active site
176299009262	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009263	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009264	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
176299009265	substrate binding site [chemical binding]; other site
176299009266	ATP binding site [chemical binding]; other site
176299009267	Predicted tagatose 6-phosphate kinase [Carbohydrate transport and metabolism]; Region: GatZ; COG4573
176299009268	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299009269	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009270	dimer interface [polypeptide binding]; other site
176299009271	conserved gate region; other site
176299009272	putative PBP binding loops; other site
176299009273	ABC-ATPase subunit interface; other site
176299009274	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009276	dimer interface [polypeptide binding]; other site
176299009277	conserved gate region; other site
176299009278	putative PBP binding loops; other site
176299009279	ABC-ATPase subunit interface; other site
176299009280	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299009281	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009282	Walker A/P-loop; other site
176299009283	ATP binding site [chemical binding]; other site
176299009284	Q-loop/lid; other site
176299009285	ABC transporter signature motif; other site
176299009286	Walker B; other site
176299009287	D-loop; other site
176299009288	H-loop/switch region; other site
176299009289	TOBE domain; Region: TOBE_2; pfam08402
176299009290	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299009291	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009292	Walker A/P-loop; other site
176299009293	ATP binding site [chemical binding]; other site
176299009294	Q-loop/lid; other site
176299009295	ABC transporter signature motif; other site
176299009296	Walker B; other site
176299009297	D-loop; other site
176299009298	H-loop/switch region; other site
176299009299	TOBE domain; Region: TOBE_2; pfam08402
176299009300	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009302	dimer interface [polypeptide binding]; other site
176299009303	conserved gate region; other site
176299009304	putative PBP binding loops; other site
176299009305	ABC-ATPase subunit interface; other site
176299009306	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299009307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009308	dimer interface [polypeptide binding]; other site
176299009309	conserved gate region; other site
176299009310	putative PBP binding loops; other site
176299009311	ABC-ATPase subunit interface; other site
176299009312	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009313	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009314	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
176299009315	homodimer interface [polypeptide binding]; other site
176299009316	substrate-cofactor binding pocket; other site
176299009317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299009318	catalytic residue [active]
176299009319	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299009320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299009321	DNA-binding site [nucleotide binding]; DNA binding site
176299009322	FCD domain; Region: FCD; pfam07729
176299009323	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
176299009324	RNA/DNA hybrid binding site [nucleotide binding]; other site
176299009325	active site
176299009326	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
176299009327	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
176299009328	metal binding site [ion binding]; metal-binding site
176299009329	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
176299009330	ABC-ATPase subunit  interface; other site
176299009331	dimer interface [polypeptide binding]; other site
176299009332	putative PBP binding regions; other site
176299009333	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
176299009334	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
176299009335	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
176299009336	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
176299009337	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
176299009338	Predicted membrane protein [Function unknown]; Region: COG1238
176299009339	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
176299009340	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299009341	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
176299009342	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009343	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
176299009344	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299009345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009346	dimer interface [polypeptide binding]; other site
176299009347	conserved gate region; other site
176299009348	putative PBP binding loops; other site
176299009349	ABC-ATPase subunit interface; other site
176299009350	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009352	dimer interface [polypeptide binding]; other site
176299009353	conserved gate region; other site
176299009354	putative PBP binding loops; other site
176299009355	ABC-ATPase subunit interface; other site
176299009356	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299009357	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009358	Walker A/P-loop; other site
176299009359	ATP binding site [chemical binding]; other site
176299009360	Q-loop/lid; other site
176299009361	ABC transporter signature motif; other site
176299009362	Walker B; other site
176299009363	D-loop; other site
176299009364	H-loop/switch region; other site
176299009365	TOBE domain; Region: TOBE_2; pfam08402
176299009366	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
176299009367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299009368	S-adenosylmethionine binding site [chemical binding]; other site
176299009369	replicative DNA helicase; Provisional; Region: PRK05973
176299009370	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
176299009371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299009372	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299009373	putative substrate translocation pore; other site
176299009374	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299009375	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299009376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299009377	Coenzyme A binding pocket [chemical binding]; other site
176299009378	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
176299009379	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
176299009380	dimer interface [polypeptide binding]; other site
176299009381	active site
176299009382	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299009383	catalytic residues [active]
176299009384	substrate binding site [chemical binding]; other site
176299009385	speF leader; predicted by RFAM
176299009386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299009387	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299009388	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299009389	putative effector binding pocket; other site
176299009390	dimerization interface [polypeptide binding]; other site
176299009391	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299009392	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311
176299009393	putative ligand binding site [chemical binding]; other site
176299009394	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299009395	TM-ABC transporter signature motif; other site
176299009396	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299009397	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299009398	Walker A/P-loop; other site
176299009399	ATP binding site [chemical binding]; other site
176299009400	Q-loop/lid; other site
176299009401	ABC transporter signature motif; other site
176299009402	Walker B; other site
176299009403	D-loop; other site
176299009404	H-loop/switch region; other site
176299009405	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299009406	DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975
176299009407	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299009408	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
176299009409	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
176299009410	MMPL family; Region: MMPL; cl14618
176299009411	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
176299009412	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299009413	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299009414	PAS domain; Region: PAS_9; pfam13426
176299009415	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299009416	PAS domain; Region: PAS_9; pfam13426
176299009417	putative active site [active]
176299009418	heme pocket [chemical binding]; other site
176299009419	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299009420	metal binding site [ion binding]; metal-binding site
176299009421	active site
176299009422	I-site; other site
176299009423	hypothetical protein; Provisional; Region: PRK11171
176299009424	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
176299009425	Cupin domain; Region: Cupin_2; pfam07883
176299009426	Methyltransferase domain; Region: Methyltransf_25; pfam13649
176299009427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299009428	metal binding site [ion binding]; metal-binding site
176299009429	active site
176299009430	I-site; other site
176299009431	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299009432	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
176299009433	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
176299009434	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
176299009435	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
176299009436	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299009437	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
176299009438	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
176299009439	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299009440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009441	dimer interface [polypeptide binding]; other site
176299009442	conserved gate region; other site
176299009443	putative PBP binding loops; other site
176299009444	ABC-ATPase subunit interface; other site
176299009445	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299009446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009447	dimer interface [polypeptide binding]; other site
176299009448	conserved gate region; other site
176299009449	putative PBP binding loops; other site
176299009450	ABC-ATPase subunit interface; other site
176299009451	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299009452	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299009453	Walker A/P-loop; other site
176299009454	ATP binding site [chemical binding]; other site
176299009455	Q-loop/lid; other site
176299009456	ABC transporter signature motif; other site
176299009457	Walker B; other site
176299009458	D-loop; other site
176299009459	H-loop/switch region; other site
176299009460	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299009461	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299009462	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299009463	Walker A/P-loop; other site
176299009464	ATP binding site [chemical binding]; other site
176299009465	Q-loop/lid; other site
176299009466	ABC transporter signature motif; other site
176299009467	Walker B; other site
176299009468	D-loop; other site
176299009469	H-loop/switch region; other site
176299009470	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
176299009471	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299009472	catalytic residue [active]
176299009473	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
176299009474	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299009475	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
176299009476	putative ligand binding site [chemical binding]; other site
176299009477	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299009478	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299009479	Walker A/P-loop; other site
176299009480	ATP binding site [chemical binding]; other site
176299009481	Q-loop/lid; other site
176299009482	ABC transporter signature motif; other site
176299009483	Walker B; other site
176299009484	D-loop; other site
176299009485	H-loop/switch region; other site
176299009486	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299009487	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299009488	TM-ABC transporter signature motif; other site
176299009489	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299009490	TM-ABC transporter signature motif; other site
176299009491	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299009492	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299009493	DNA-binding site [nucleotide binding]; DNA binding site
176299009494	FCD domain; Region: FCD; pfam07729
176299009495	Cupin; Region: Cupin_6; pfam12852
176299009496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299009497	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299009498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299009499	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
176299009500	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
176299009501	putative active site [active]
176299009502	putative PHP Thumb interface [polypeptide binding]; other site
176299009503	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
176299009504	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
176299009505	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
176299009506	generic binding surface I; other site
176299009507	generic binding surface II; other site
176299009508	DNA Polymerase Y-family; Region: PolY_like; cd03468
176299009509	active site
176299009510	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
176299009511	DNA binding site [nucleotide binding]
176299009512	Uncharacterized conserved protein [Function unknown]; Region: COG4544
176299009513	Predicted membrane protein [Function unknown]; Region: COG3759
176299009514	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
176299009515	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
176299009516	MOFRL family; Region: MOFRL; pfam05161
176299009517	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299009518	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299009519	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299009520	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299009521	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299009522	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
176299009523	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299009524	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009525	Walker A/P-loop; other site
176299009526	ATP binding site [chemical binding]; other site
176299009527	Q-loop/lid; other site
176299009528	ABC transporter signature motif; other site
176299009529	Walker B; other site
176299009530	D-loop; other site
176299009531	H-loop/switch region; other site
176299009532	TOBE domain; Region: TOBE_2; pfam08402
176299009533	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009535	dimer interface [polypeptide binding]; other site
176299009536	conserved gate region; other site
176299009537	putative PBP binding loops; other site
176299009538	ABC-ATPase subunit interface; other site
176299009539	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299009540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
176299009541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009542	putative PBP binding loops; other site
176299009543	dimer interface [polypeptide binding]; other site
176299009544	ABC-ATPase subunit interface; other site
176299009545	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009546	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009547	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299009548	putative DNA binding site [nucleotide binding]; other site
176299009549	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299009550	dimerization interface [polypeptide binding]; other site
176299009551	putative Zn2+ binding site [ion binding]; other site
176299009552	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299009553	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
176299009554	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299009555	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299009556	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299009557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3828
176299009558	hypothetical protein; Provisional; Region: PRK06102
176299009559	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299009560	dimerization interface [polypeptide binding]; other site
176299009561	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299009562	metal binding site [ion binding]; metal-binding site
176299009563	active site
176299009564	I-site; other site
176299009565	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299009566	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299009567	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299009568	substrate binding pocket [chemical binding]; other site
176299009569	membrane-bound complex binding site; other site
176299009570	hinge residues; other site
176299009571	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299009572	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299009573	substrate binding pocket [chemical binding]; other site
176299009574	membrane-bound complex binding site; other site
176299009575	hinge residues; other site
176299009576	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
176299009577	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
176299009578	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
176299009579	P-loop; other site
176299009580	ADP binding residues [chemical binding]; other site
176299009581	Switch I; other site
176299009582	Switch II; other site
176299009583	septum formation inhibitor; Reviewed; Region: minC; PRK05177
176299009584	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
176299009585	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
176299009586	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
176299009587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299009588	active site
176299009589	motif I; other site
176299009590	motif II; other site
176299009591	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299009592	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299009593	DNA-binding site [nucleotide binding]; DNA binding site
176299009594	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299009595	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
176299009596	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
176299009597	DctM-like transporters; Region: DctM; pfam06808
176299009598	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
176299009599	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
176299009600	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
176299009601	putative NAD(P) binding site [chemical binding]; other site
176299009602	catalytic Zn binding site [ion binding]; other site
176299009603	mannonate dehydratase; Provisional; Region: PRK03906
176299009604	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
176299009605	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
176299009606	dimer interface [polypeptide binding]; other site
176299009607	NADP binding site [chemical binding]; other site
176299009608	catalytic residues [active]
176299009609	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
176299009610	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
176299009611	DctM-like transporters; Region: DctM; pfam06808
176299009612	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
176299009613	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299009614	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299009615	Walker A/P-loop; other site
176299009616	ATP binding site [chemical binding]; other site
176299009617	Q-loop/lid; other site
176299009618	ABC transporter signature motif; other site
176299009619	Walker B; other site
176299009620	D-loop; other site
176299009621	H-loop/switch region; other site
176299009622	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299009623	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299009624	Walker A/P-loop; other site
176299009625	ATP binding site [chemical binding]; other site
176299009626	Q-loop/lid; other site
176299009627	ABC transporter signature motif; other site
176299009628	Walker B; other site
176299009629	D-loop; other site
176299009630	H-loop/switch region; other site
176299009631	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299009632	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
176299009633	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299009634	catalytic residue [active]
176299009635	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
176299009636	Transcriptional regulator [Transcription]; Region: IclR; COG1414
176299009637	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299009638	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
176299009639	homotrimer interaction site [polypeptide binding]; other site
176299009640	putative active site [active]
176299009641	Predicted amidohydrolase [General function prediction only]; Region: COG3964
176299009642	Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307
176299009643	active site
176299009644	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299009645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009646	dimer interface [polypeptide binding]; other site
176299009647	conserved gate region; other site
176299009648	putative PBP binding loops; other site
176299009649	ABC-ATPase subunit interface; other site
176299009650	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299009651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009652	dimer interface [polypeptide binding]; other site
176299009653	conserved gate region; other site
176299009654	putative PBP binding loops; other site
176299009655	ABC-ATPase subunit interface; other site
176299009656	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299009657	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
176299009658	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299009659	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
176299009660	putative ADP-binding pocket [chemical binding]; other site
176299009661	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
176299009662	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
176299009663	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299009664	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299009665	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299009666	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299009667	MMPL family; Region: MMPL; cl14618
176299009668	MMPL family; Region: MMPL; cl14618
176299009669	Invasion protein B, involved in pathogenesis [General function prediction only]; Region: COG5342
176299009670	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
176299009671	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
176299009672	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
176299009673	Autotransporter beta-domain; Region: Autotransporter; pfam03797
176299009674	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
176299009675	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299009676	active site
176299009677	catalytic tetrad [active]
176299009678	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
176299009679	active site
176299009680	dimer interface [polypeptide binding]; other site
176299009681	non-prolyl cis peptide bond; other site
176299009682	insertion regions; other site
176299009683	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
176299009684	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299009685	DNA-binding site [nucleotide binding]; DNA binding site
176299009686	UTRA domain; Region: UTRA; pfam07702
176299009687	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299009688	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009689	Walker A/P-loop; other site
176299009690	ATP binding site [chemical binding]; other site
176299009691	Q-loop/lid; other site
176299009692	ABC transporter signature motif; other site
176299009693	Walker B; other site
176299009694	D-loop; other site
176299009695	H-loop/switch region; other site
176299009696	TOBE domain; Region: TOBE; pfam03459
176299009697	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009698	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009700	dimer interface [polypeptide binding]; other site
176299009701	conserved gate region; other site
176299009702	putative PBP binding loops; other site
176299009703	ABC-ATPase subunit interface; other site
176299009704	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009706	dimer interface [polypeptide binding]; other site
176299009707	conserved gate region; other site
176299009708	putative PBP binding loops; other site
176299009709	ABC-ATPase subunit interface; other site
176299009710	alpha-glucosidase; Provisional; Region: PRK10426
176299009711	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
176299009712	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
176299009713	putative active site [active]
176299009714	putative catalytic site [active]
176299009715	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299009716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009717	dimer interface [polypeptide binding]; other site
176299009718	conserved gate region; other site
176299009719	putative PBP binding loops; other site
176299009720	ABC-ATPase subunit interface; other site
176299009721	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
176299009722	NMT1/THI5 like; Region: NMT1; pfam09084
176299009723	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
176299009724	substrate binding site [chemical binding]; other site
176299009725	multimerization interface [polypeptide binding]; other site
176299009726	ATP binding site [chemical binding]; other site
176299009727	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
176299009728	active site
176299009729	thiamine phosphate binding site [chemical binding]; other site
176299009730	pyrophosphate binding site [ion binding]; other site
176299009731	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
176299009732	dimer interface [polypeptide binding]; other site
176299009733	substrate binding site [chemical binding]; other site
176299009734	ATP binding site [chemical binding]; other site
176299009735	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299009736	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299009737	putative DNA binding site [nucleotide binding]; other site
176299009738	putative Zn2+ binding site [ion binding]; other site
176299009739	AsnC family; Region: AsnC_trans_reg; pfam01037
176299009740	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
176299009741	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
176299009742	active site
176299009743	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299009744	dimer interface [polypeptide binding]; other site
176299009745	substrate binding site [chemical binding]; other site
176299009746	catalytic residues [active]
176299009747	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
176299009748	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299009749	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299009750	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299009751	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299009752	DNA-binding site [nucleotide binding]; DNA binding site
176299009753	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299009754	BA14K-like protein; Region: BA14K; pfam07886
176299009755	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
176299009756	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299009757	active site
176299009758	phosphorylation site [posttranslational modification]
176299009759	intermolecular recognition site; other site
176299009760	dimerization interface [polypeptide binding]; other site
176299009761	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299009762	Walker A motif; other site
176299009763	ATP binding site [chemical binding]; other site
176299009764	Walker B motif; other site
176299009765	arginine finger; other site
176299009766	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
176299009767	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
176299009768	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299009769	dimer interface [polypeptide binding]; other site
176299009770	phosphorylation site [posttranslational modification]
176299009771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299009772	ATP binding site [chemical binding]; other site
176299009773	Mg2+ binding site [ion binding]; other site
176299009774	G-X-G motif; other site
176299009775	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
176299009776	Predicted membrane protein [Function unknown]; Region: COG2510
176299009777	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299009778	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299009779	inhibitor-cofactor binding pocket; inhibition site
176299009780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299009781	catalytic residue [active]
176299009782	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299009783	classical (c) SDRs; Region: SDR_c; cd05233
176299009784	NAD(P) binding site [chemical binding]; other site
176299009785	active site
176299009786	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
176299009787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299009788	Tetratricopeptide repeat; Region: TPR_16; pfam13432
176299009789	binding surface
176299009790	TPR motif; other site
176299009791	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
176299009792	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299009793	binding surface
176299009794	TPR motif; other site
176299009795	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
176299009796	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668
176299009797	metal binding site [ion binding]; metal-binding site
176299009798	putative dimer interface [polypeptide binding]; other site
176299009799	Endoglucanase Y [Carbohydrate transport and metabolism]; Region: CelA; COG3405
176299009800	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
176299009801	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
176299009802	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
176299009803	DXD motif; other site
176299009804	PilZ domain; Region: PilZ; pfam07238
176299009805	Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908
176299009806	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
176299009807	dimerization interface [polypeptide binding]; other site
176299009808	putative active cleft [active]
176299009809	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
176299009810	Protein of unknown function (DUF995); Region: DUF995; pfam06191
176299009811	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
176299009812	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299009813	active site
176299009814	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
176299009815	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
176299009816	NAD binding site [chemical binding]; other site
176299009817	homodimer interface [polypeptide binding]; other site
176299009818	active site
176299009819	substrate binding site [chemical binding]; other site
176299009820	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
176299009821	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299009822	NAD binding site [chemical binding]; other site
176299009823	putative substrate binding site 2 [chemical binding]; other site
176299009824	putative substrate binding site 1 [chemical binding]; other site
176299009825	active site
176299009826	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299009827	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299009828	DNA binding residues [nucleotide binding]
176299009829	dimerization interface [polypeptide binding]; other site
176299009830	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
176299009831	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299009832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299009833	Walker A/P-loop; other site
176299009834	ATP binding site [chemical binding]; other site
176299009835	Q-loop/lid; other site
176299009836	ABC transporter signature motif; other site
176299009837	Walker B; other site
176299009838	D-loop; other site
176299009839	H-loop/switch region; other site
176299009840	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
176299009841	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299009842	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299009843	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
176299009844	O-Antigen ligase; Region: Wzy_C; pfam04932
176299009845	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
176299009846	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
176299009847	SLBB domain; Region: SLBB; pfam10531
176299009848	Bacterial sugar transferase; Region: Bac_transf; pfam02397
176299009849	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
176299009850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299009851	non-specific DNA binding site [nucleotide binding]; other site
176299009852	salt bridge; other site
176299009853	sequence-specific DNA binding site [nucleotide binding]; other site
176299009854	Cupin domain; Region: Cupin_2; pfam07883
176299009855	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299009856	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299009857	inhibitor-cofactor binding pocket; inhibition site
176299009858	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299009859	catalytic residue [active]
176299009860	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299009861	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299009862	dimer interface [polypeptide binding]; other site
176299009863	putative CheW interface [polypeptide binding]; other site
176299009864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299009865	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299009866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
176299009867	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299009868	classical (c) SDRs; Region: SDR_c; cd05233
176299009869	NAD(P) binding site [chemical binding]; other site
176299009870	active site
176299009871	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
176299009872	active site
176299009873	DNA binding site [nucleotide binding]
176299009874	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299009875	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299009876	DNA binding site [nucleotide binding]
176299009877	domain linker motif; other site
176299009878	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
176299009879	ligand binding site [chemical binding]; other site
176299009880	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009881	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009882	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299009883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009884	dimer interface [polypeptide binding]; other site
176299009885	conserved gate region; other site
176299009886	putative PBP binding loops; other site
176299009887	ABC-ATPase subunit interface; other site
176299009888	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009890	dimer interface [polypeptide binding]; other site
176299009891	conserved gate region; other site
176299009892	putative PBP binding loops; other site
176299009893	ABC-ATPase subunit interface; other site
176299009894	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299009895	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009896	Walker A/P-loop; other site
176299009897	ATP binding site [chemical binding]; other site
176299009898	Q-loop/lid; other site
176299009899	ABC transporter signature motif; other site
176299009900	Walker B; other site
176299009901	D-loop; other site
176299009902	H-loop/switch region; other site
176299009903	TOBE domain; Region: TOBE_2; pfam08402
176299009904	Trehalose utilization protein [Carbohydrate transport and metabolism]; Region: ThuA; COG4813
176299009905	conserved cys residue [active]
176299009906	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299009907	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299009908	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299009909	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
176299009910	4Fe-4S single cluster domain; Region: Fer4_14; pfam13394
176299009911	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
176299009912	active site
176299009913	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
176299009914	Ligand Binding Site [chemical binding]; other site
176299009915	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299009916	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299009917	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299009918	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299009919	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299009920	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299009921	Walker A/P-loop; other site
176299009922	ATP binding site [chemical binding]; other site
176299009923	Q-loop/lid; other site
176299009924	ABC transporter signature motif; other site
176299009925	Walker B; other site
176299009926	D-loop; other site
176299009927	H-loop/switch region; other site
176299009928	TOBE domain; Region: TOBE_2; pfam08402
176299009929	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299009930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009931	dimer interface [polypeptide binding]; other site
176299009932	conserved gate region; other site
176299009933	putative PBP binding loops; other site
176299009934	ABC-ATPase subunit interface; other site
176299009935	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299009936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009937	dimer interface [polypeptide binding]; other site
176299009938	conserved gate region; other site
176299009939	putative PBP binding loops; other site
176299009940	ABC-ATPase subunit interface; other site
176299009941	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299009942	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299009943	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
176299009944	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
176299009945	Substrate binding site; other site
176299009946	Cupin domain; Region: Cupin_2; cl17218
176299009947	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
176299009948	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
176299009949	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
176299009950	Trp docking motif [polypeptide binding]; other site
176299009951	putative active site [active]
176299009952	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299009953	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299009954	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
176299009955	dimerization interface [polypeptide binding]; other site
176299009956	substrate binding pocket [chemical binding]; other site
176299009957	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
176299009958	Malic enzyme, N-terminal domain; Region: malic; pfam00390
176299009959	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
176299009960	putative NAD(P) binding site [chemical binding]; other site
176299009961	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
176299009962	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299009963	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299009964	substrate binding pocket [chemical binding]; other site
176299009965	membrane-bound complex binding site; other site
176299009966	hinge residues; other site
176299009967	ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003
176299009968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009969	dimer interface [polypeptide binding]; other site
176299009970	conserved gate region; other site
176299009971	putative PBP binding loops; other site
176299009972	ABC-ATPase subunit interface; other site
176299009973	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299009974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299009975	dimer interface [polypeptide binding]; other site
176299009976	conserved gate region; other site
176299009977	putative PBP binding loops; other site
176299009978	ABC-ATPase subunit interface; other site
176299009979	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299009980	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299009981	Walker A/P-loop; other site
176299009982	ATP binding site [chemical binding]; other site
176299009983	Q-loop/lid; other site
176299009984	ABC transporter signature motif; other site
176299009985	Walker B; other site
176299009986	D-loop; other site
176299009987	H-loop/switch region; other site
176299009988	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
176299009989	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
176299009990	active site
176299009991	non-prolyl cis peptide bond; other site
176299009992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299009993	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299009994	putative active site [active]
176299009995	heme pocket [chemical binding]; other site
176299009996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299009997	putative active site [active]
176299009998	heme pocket [chemical binding]; other site
176299009999	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299010000	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299010001	dimer interface [polypeptide binding]; other site
176299010002	putative CheW interface [polypeptide binding]; other site
176299010003	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299010004	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299010005	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299010006	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
176299010007	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
176299010008	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
176299010009	DctM-like transporters; Region: DctM; pfam06808
176299010010	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
176299010011	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
176299010012	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
176299010013	catalytic triad [active]
176299010014	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299010015	TM-ABC transporter signature motif; other site
176299010016	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299010017	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299010018	Walker A/P-loop; other site
176299010019	ATP binding site [chemical binding]; other site
176299010020	Q-loop/lid; other site
176299010021	ABC transporter signature motif; other site
176299010022	Walker B; other site
176299010023	D-loop; other site
176299010024	H-loop/switch region; other site
176299010025	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299010026	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299010027	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
176299010028	putative ligand binding site [chemical binding]; other site
176299010029	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
176299010030	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
176299010031	putative metal binding site [ion binding]; other site
176299010032	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299010033	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502
176299010034	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
176299010035	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
176299010036	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299010037	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010038	Walker A/P-loop; other site
176299010039	ATP binding site [chemical binding]; other site
176299010040	Q-loop/lid; other site
176299010041	ABC transporter signature motif; other site
176299010042	Walker B; other site
176299010043	D-loop; other site
176299010044	H-loop/switch region; other site
176299010045	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299010046	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010047	Walker A/P-loop; other site
176299010048	ATP binding site [chemical binding]; other site
176299010049	Q-loop/lid; other site
176299010050	ABC transporter signature motif; other site
176299010051	Walker B; other site
176299010052	D-loop; other site
176299010053	H-loop/switch region; other site
176299010054	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299010055	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299010056	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010057	dimer interface [polypeptide binding]; other site
176299010058	conserved gate region; other site
176299010059	putative PBP binding loops; other site
176299010060	ABC-ATPase subunit interface; other site
176299010061	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299010062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010063	dimer interface [polypeptide binding]; other site
176299010064	conserved gate region; other site
176299010065	putative PBP binding loops; other site
176299010066	ABC-ATPase subunit interface; other site
176299010067	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299010068	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299010069	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
176299010070	putative dimerization interface [polypeptide binding]; other site
176299010071	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
176299010072	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
176299010073	lipoyl-biotinyl attachment site [posttranslational modification]; other site
176299010074	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299010075	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
176299010076	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299010077	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
176299010078	Walker A/P-loop; other site
176299010079	ATP binding site [chemical binding]; other site
176299010080	Q-loop/lid; other site
176299010081	ABC transporter signature motif; other site
176299010082	Walker B; other site
176299010083	D-loop; other site
176299010084	H-loop/switch region; other site
176299010085	Secretin and TonB N terminus short domain; Region: STN; smart00965
176299010086	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
176299010087	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
176299010088	N-terminal plug; other site
176299010089	ligand-binding site [chemical binding]; other site
176299010090	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
176299010091	FecR protein; Region: FecR; pfam04773
176299010092	extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037
176299010093	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299010094	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
176299010095	DNA binding residues [nucleotide binding]
176299010096	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
176299010097	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
176299010098	Walker A/P-loop; other site
176299010099	ATP binding site [chemical binding]; other site
176299010100	Q-loop/lid; other site
176299010101	ABC transporter signature motif; other site
176299010102	Walker B; other site
176299010103	D-loop; other site
176299010104	H-loop/switch region; other site
176299010105	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299010106	ABC-ATPase subunit  interface; other site
176299010107	dimer interface [polypeptide binding]; other site
176299010108	putative PBP binding regions; other site
176299010109	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
176299010110	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
176299010111	putative ligand binding residues [chemical binding]; other site
176299010112	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
176299010113	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
176299010114	putative ligand binding residues [chemical binding]; other site
176299010115	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299010116	S-adenosylmethionine binding site [chemical binding]; other site
176299010117	Pseudoazurin (Paz) is a type I blue copper electron-transfer protein; Region: Pseudoazurin; cd04218
176299010118	Type 1 (T1) Cu binding site [ion binding]; other site
176299010119	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
176299010120	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
176299010121	Walker A/P-loop; other site
176299010122	ATP binding site [chemical binding]; other site
176299010123	Q-loop/lid; other site
176299010124	ABC transporter signature motif; other site
176299010125	Walker B; other site
176299010126	D-loop; other site
176299010127	H-loop/switch region; other site
176299010128	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299010129	ABC-ATPase subunit  interface; other site
176299010130	dimer interface [polypeptide binding]; other site
176299010131	putative PBP binding regions; other site
176299010132	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
176299010133	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
176299010134	putative ligand binding residues [chemical binding]; other site
176299010135	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
176299010136	acetylornithine deacetylase; Provisional; Region: PRK07522
176299010137	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
176299010138	metal binding site [ion binding]; metal-binding site
176299010139	putative dimer interface [polypeptide binding]; other site
176299010140	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299010141	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
176299010142	putative ligand binding site [chemical binding]; other site
176299010143	NAD binding site [chemical binding]; other site
176299010144	dimerization interface [polypeptide binding]; other site
176299010145	catalytic site [active]
176299010146	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
176299010147	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
176299010148	NAD(P) binding site [chemical binding]; other site
176299010149	catalytic residues [active]
176299010150	tartrate dehydrogenase; Region: TTC; TIGR02089
176299010151	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
176299010152	tetramerization interface [polypeptide binding]; other site
176299010153	NAD(P) binding site [chemical binding]; other site
176299010154	catalytic residues [active]
176299010155	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299010156	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299010157	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
176299010158	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
176299010159	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299010160	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299010161	Coenzyme A binding pocket [chemical binding]; other site
176299010162	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299010163	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299010164	inhibitor-cofactor binding pocket; inhibition site
176299010165	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299010166	catalytic residue [active]
176299010167	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
176299010168	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
176299010169	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299010170	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
176299010171	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299010172	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010173	dimer interface [polypeptide binding]; other site
176299010174	conserved gate region; other site
176299010175	putative PBP binding loops; other site
176299010176	ABC-ATPase subunit interface; other site
176299010177	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299010178	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010179	dimer interface [polypeptide binding]; other site
176299010180	conserved gate region; other site
176299010181	ABC-ATPase subunit interface; other site
176299010182	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299010183	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010184	Walker A/P-loop; other site
176299010185	ATP binding site [chemical binding]; other site
176299010186	Q-loop/lid; other site
176299010187	ABC transporter signature motif; other site
176299010188	Walker B; other site
176299010189	D-loop; other site
176299010190	H-loop/switch region; other site
176299010191	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299010192	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010193	Walker A/P-loop; other site
176299010194	ATP binding site [chemical binding]; other site
176299010195	Q-loop/lid; other site
176299010196	ABC transporter signature motif; other site
176299010197	Walker B; other site
176299010198	D-loop; other site
176299010199	H-loop/switch region; other site
176299010200	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299010201	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299010202	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299010203	putative DNA binding site [nucleotide binding]; other site
176299010204	putative Zn2+ binding site [ion binding]; other site
176299010205	AsnC family; Region: AsnC_trans_reg; pfam01037
176299010206	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299010207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299010208	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299010209	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299010210	substrate binding pocket [chemical binding]; other site
176299010211	membrane-bound complex binding site; other site
176299010212	hinge residues; other site
176299010213	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299010214	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299010215	substrate binding pocket [chemical binding]; other site
176299010216	membrane-bound complex binding site; other site
176299010217	hinge residues; other site
176299010218	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299010219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010220	dimer interface [polypeptide binding]; other site
176299010221	conserved gate region; other site
176299010222	putative PBP binding loops; other site
176299010223	ABC-ATPase subunit interface; other site
176299010224	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299010225	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299010226	Walker A/P-loop; other site
176299010227	ATP binding site [chemical binding]; other site
176299010228	Q-loop/lid; other site
176299010229	ABC transporter signature motif; other site
176299010230	Walker B; other site
176299010231	D-loop; other site
176299010232	H-loop/switch region; other site
176299010233	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299010234	Coenzyme A binding pocket [chemical binding]; other site
176299010235	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
176299010236	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
176299010237	metal binding site [ion binding]; metal-binding site
176299010238	putative dimer interface [polypeptide binding]; other site
176299010239	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
176299010240	active site
176299010241	non-prolyl cis peptide bond; other site
176299010242	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
176299010243	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299010244	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299010245	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
176299010246	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
176299010247	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
176299010248	active site
176299010249	dimer interface [polypeptide binding]; other site
176299010250	non-prolyl cis peptide bond; other site
176299010251	insertion regions; other site
176299010252	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
176299010253	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299010254	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
176299010255	active site
176299010256	dimer interface [polypeptide binding]; other site
176299010257	non-prolyl cis peptide bond; other site
176299010258	insertion regions; other site
176299010259	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932
176299010260	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299010261	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
176299010262	active site
176299010263	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299010264	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299010265	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299010266	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
176299010267	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299010268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010269	dimer interface [polypeptide binding]; other site
176299010270	conserved gate region; other site
176299010271	putative PBP binding loops; other site
176299010272	ABC-ATPase subunit interface; other site
176299010273	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299010274	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299010275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010276	dimer interface [polypeptide binding]; other site
176299010277	conserved gate region; other site
176299010278	putative PBP binding loops; other site
176299010279	ABC-ATPase subunit interface; other site
176299010280	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
176299010281	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010282	Walker A/P-loop; other site
176299010283	ATP binding site [chemical binding]; other site
176299010284	Q-loop/lid; other site
176299010285	ABC transporter signature motif; other site
176299010286	Walker B; other site
176299010287	D-loop; other site
176299010288	H-loop/switch region; other site
176299010289	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299010290	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
176299010291	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010292	Walker A/P-loop; other site
176299010293	ATP binding site [chemical binding]; other site
176299010294	Q-loop/lid; other site
176299010295	ABC transporter signature motif; other site
176299010296	Walker B; other site
176299010297	D-loop; other site
176299010298	H-loop/switch region; other site
176299010299	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299010300	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299010301	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299010302	active site
176299010303	catalytic tetrad [active]
176299010304	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
176299010305	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
176299010306	Flavin binding site [chemical binding]; other site
176299010307	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299010308	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299010309	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299010310	dimerization interface [polypeptide binding]; other site
176299010311	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
176299010312	active site
176299010313	non-prolyl cis peptide bond; other site
176299010314	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299010315	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
176299010316	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299010317	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
176299010318	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
176299010319	amidohydrolase; Region: amidohydrolases; TIGR01891
176299010320	metal binding site [ion binding]; metal-binding site
176299010321	putative dimer interface [polypeptide binding]; other site
176299010322	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
176299010323	active site
176299010324	dimer interface [polypeptide binding]; other site
176299010325	non-prolyl cis peptide bond; other site
176299010326	insertion regions; other site
176299010327	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
176299010328	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299010329	NAD(P) binding site [chemical binding]; other site
176299010330	active site
176299010331	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299010332	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299010333	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
176299010334	active site
176299010335	non-prolyl cis peptide bond; other site
176299010336	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
176299010337	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299010338	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
176299010339	putative active site pocket [active]
176299010340	metal binding site [ion binding]; metal-binding site
176299010341	SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839
176299010342	active site
176299010343	catalytic triad [active]
176299010344	oxyanion hole [active]
176299010345	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299010346	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
176299010347	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299010348	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010349	Walker A/P-loop; other site
176299010350	ATP binding site [chemical binding]; other site
176299010351	Q-loop/lid; other site
176299010352	ABC transporter signature motif; other site
176299010353	Walker B; other site
176299010354	D-loop; other site
176299010355	H-loop/switch region; other site
176299010356	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299010357	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299010358	Walker A/P-loop; other site
176299010359	ATP binding site [chemical binding]; other site
176299010360	Q-loop/lid; other site
176299010361	ABC transporter signature motif; other site
176299010362	Walker B; other site
176299010363	D-loop; other site
176299010364	H-loop/switch region; other site
176299010365	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299010366	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299010367	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010368	dimer interface [polypeptide binding]; other site
176299010369	conserved gate region; other site
176299010370	putative PBP binding loops; other site
176299010371	ABC-ATPase subunit interface; other site
176299010372	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299010373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010374	dimer interface [polypeptide binding]; other site
176299010375	conserved gate region; other site
176299010376	putative PBP binding loops; other site
176299010377	ABC-ATPase subunit interface; other site
176299010378	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299010379	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299010380	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299010381	DNA-binding site [nucleotide binding]; DNA binding site
176299010382	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299010383	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
176299010384	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
176299010385	conserved cys residue [active]
176299010386	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299010387	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299010388	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299010389	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299010390	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
176299010391	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299010392	NAD(P) binding site [chemical binding]; other site
176299010393	active site
176299010394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3453
176299010395	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
176299010396	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299010397	dimerization interface [polypeptide binding]; other site
176299010398	putative DNA binding site [nucleotide binding]; other site
176299010399	putative Zn2+ binding site [ion binding]; other site
176299010400	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
176299010401	Predicted transporter component [General function prediction only]; Region: COG2391
176299010402	Predicted transporter component [General function prediction only]; Region: COG2391
176299010403	Sulphur transport; Region: Sulf_transp; pfam04143
176299010404	phosphoglyceromutase; Provisional; Region: PRK05434
176299010405	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
176299010406	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
176299010407	E3 interaction surface; other site
176299010408	lipoyl attachment site [posttranslational modification]; other site
176299010409	e3 binding domain; Region: E3_binding; pfam02817
176299010410	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
176299010411	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
176299010412	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
176299010413	alpha subunit interface [polypeptide binding]; other site
176299010414	TPP binding site [chemical binding]; other site
176299010415	heterodimer interface [polypeptide binding]; other site
176299010416	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
176299010417	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
176299010418	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
176299010419	tetramer interface [polypeptide binding]; other site
176299010420	TPP-binding site [chemical binding]; other site
176299010421	heterodimer interface [polypeptide binding]; other site
176299010422	phosphorylation loop region [posttranslational modification]
176299010423	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299010424	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
176299010425	active site
176299010426	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
176299010427	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
176299010428	dimer interface [polypeptide binding]; other site
176299010429	active site
176299010430	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299010431	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299010432	putative DNA binding site [nucleotide binding]; other site
176299010433	putative Zn2+ binding site [ion binding]; other site
176299010434	AsnC family; Region: AsnC_trans_reg; pfam01037
176299010435	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
176299010436	isovaleryl-CoA dehydrogenase; Region: PLN02519
176299010437	substrate binding site [chemical binding]; other site
176299010438	FAD binding site [chemical binding]; other site
176299010439	catalytic base [active]
176299010440	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
176299010441	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
176299010442	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
176299010443	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
176299010444	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
176299010445	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299010446	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299010447	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
176299010448	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
176299010449	carboxyltransferase (CT) interaction site; other site
176299010450	biotinylation site [posttranslational modification]; other site
176299010451	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
176299010452	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
176299010453	active site
176299010454	catalytic residues [active]
176299010455	metal binding site [ion binding]; metal-binding site
176299010456	enoyl-CoA hydratase; Provisional; Region: PRK05995
176299010457	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
176299010458	substrate binding site [chemical binding]; other site
176299010459	oxyanion hole (OAH) forming residues; other site
176299010460	trimer interface [polypeptide binding]; other site
176299010461	Pantoate-beta-alanine ligase; Region: PanC; cd00560
176299010462	active site
176299010463	ATP-binding site [chemical binding]; other site
176299010464	pantoate-binding site; other site
176299010465	HXXH motif; other site
176299010466	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
176299010467	oligomerization interface [polypeptide binding]; other site
176299010468	active site
176299010469	metal binding site [ion binding]; metal-binding site
176299010470	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952
176299010471	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632
176299010472	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
176299010473	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
176299010474	putative NAD(P) binding site [chemical binding]; other site
176299010475	active site
176299010476	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
176299010477	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
176299010478	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
176299010479	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
176299010480	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299010481	ligand binding site [chemical binding]; other site
176299010482	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299010483	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299010484	Walker A/P-loop; other site
176299010485	ATP binding site [chemical binding]; other site
176299010486	Q-loop/lid; other site
176299010487	ABC transporter signature motif; other site
176299010488	Walker B; other site
176299010489	D-loop; other site
176299010490	H-loop/switch region; other site
176299010491	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299010492	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299010493	TM-ABC transporter signature motif; other site
176299010494	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299010495	TM-ABC transporter signature motif; other site
176299010496	Domain of unknown function (DUF718); Region: DUF718; pfam05336
176299010497	Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772
176299010498	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
176299010499	N- and C-terminal domain interface [polypeptide binding]; other site
176299010500	putative active site [active]
176299010501	putative MgATP binding site [chemical binding]; other site
176299010502	putative catalytic site [active]
176299010503	metal binding site [ion binding]; metal-binding site
176299010504	putative carbohydrate binding site [chemical binding]; other site
176299010505	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299010506	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299010507	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299010508	Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050
176299010509	regulatory protein CsrD; Provisional; Region: PRK11059
176299010510	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299010511	metal binding site [ion binding]; metal-binding site
176299010512	active site
176299010513	I-site; other site
176299010514	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299010515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3915
176299010516	Moco binding site; other site
176299010517	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
176299010518	tetramerization interface [polypeptide binding]; other site
176299010519	NAD(P) binding site [chemical binding]; other site
176299010520	catalytic residues [active]
176299010521	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
176299010522	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
176299010523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299010524	Walker A/P-loop; other site
176299010525	ATP binding site [chemical binding]; other site
176299010526	Q-loop/lid; other site
176299010527	ABC transporter signature motif; other site
176299010528	Walker B; other site
176299010529	D-loop; other site
176299010530	H-loop/switch region; other site
176299010531	sulfate transport protein; Provisional; Region: cysT; CHL00187
176299010532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010533	dimer interface [polypeptide binding]; other site
176299010534	conserved gate region; other site
176299010535	putative PBP binding loops; other site
176299010536	ABC-ATPase subunit interface; other site
176299010537	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299010538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299010539	dimer interface [polypeptide binding]; other site
176299010540	conserved gate region; other site
176299010541	putative PBP binding loops; other site
176299010542	ABC-ATPase subunit interface; other site
176299010543	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
176299010544	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
176299010545	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
176299010546	substrate binding site [chemical binding]; other site
176299010547	oxyanion hole (OAH) forming residues; other site
176299010548	trimer interface [polypeptide binding]; other site
176299010549	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
176299010550	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
176299010551	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
176299010552	Bacterial SH3 domain; Region: SH3_3; pfam08239
176299010553	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
176299010554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299010555	S-adenosylmethionine binding site [chemical binding]; other site
176299010556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5319
176299010557	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
176299010558	putative active site [active]
176299010559	catalytic triad [active]
176299010560	dimer interface [polypeptide binding]; other site
176299010561	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
176299010562	GSH binding site [chemical binding]; other site
176299010563	catalytic residues [active]
176299010564	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
176299010565	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299010566	active site
176299010567	C-terminal domain of RAP1 recruits proteins to telomeres; Region: rap1_RCT; cl13131
176299010568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
176299010569	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
176299010570	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
176299010571	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
176299010572	active site
176299010573	8-oxo-dGMP binding site [chemical binding]; other site
176299010574	nudix motif; other site
176299010575	metal binding site [ion binding]; metal-binding site
176299010576	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299010577	Coenzyme A binding pocket [chemical binding]; other site
176299010578	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
176299010579	heterotetramer interface [polypeptide binding]; other site
176299010580	active site pocket [active]
176299010581	cleavage site
176299010582	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
176299010583	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
176299010584	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
176299010585	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299010586	ATP binding site [chemical binding]; other site
176299010587	putative Mg++ binding site [ion binding]; other site
176299010588	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
176299010589	SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
176299010590	SEC-C motif; Region: SEC-C; pfam02810
176299010591	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299010592	EamA-like transporter family; Region: EamA; pfam00892
176299010593	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
176299010594	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
176299010595	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
176299010596	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
176299010597	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
176299010598	active site
176299010599	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299010600	active site
176299010601	catalytic tetrad [active]
176299010602	mannonate dehydratase; Provisional; Region: PRK03906
176299010603	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
176299010604	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
176299010605	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
176299010606	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
176299010607	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299010608	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299010609	NAD(P) binding site [chemical binding]; other site
176299010610	active site
176299010611	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299010612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299010613	DNA-binding site [nucleotide binding]; DNA binding site
176299010614	FCD domain; Region: FCD; pfam07729
176299010615	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
176299010616	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299010617	ligand binding site [chemical binding]; other site
176299010618	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299010619	TM-ABC transporter signature motif; other site
176299010620	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299010621	TM-ABC transporter signature motif; other site
176299010622	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299010623	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299010624	Walker A/P-loop; other site
176299010625	ATP binding site [chemical binding]; other site
176299010626	Q-loop/lid; other site
176299010627	ABC transporter signature motif; other site
176299010628	Walker B; other site
176299010629	D-loop; other site
176299010630	H-loop/switch region; other site
176299010631	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299010632	Disulfide bond formation protein DsbB [Posttranslational modification, protein turnover, chaperones]; Region: DsbB; COG1495
176299010633	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
176299010634	active site
176299010635	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
176299010636	putative protein phosphatase; Region: PHA02239
176299010637	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
176299010638	active site
176299010639	metal binding site [ion binding]; metal-binding site
176299010640	dihydroxyacetone kinase; Provisional; Region: PRK14479
176299010641	Dak1 domain; Region: Dak1; cl10557
176299010642	DAK2 domain; Region: Dak2; pfam02734
176299010643	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
176299010644	transmembrane helices; other site
176299010645	Uncharacterized conserved protein [Function unknown]; Region: COG5482
176299010646	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299010647	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
176299010648	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
176299010649	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
176299010650	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
176299010651	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
176299010652	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299010653	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
176299010654	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
176299010655	Chain length determinant protein; Region: Wzz; pfam02706
176299010656	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
176299010657	Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cd00179
176299010658	interdomain interaction site; other site
176299010659	nSec1 interaction sites; other site
176299010660	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
176299010661	linker region; other site
176299010662	AAA domain; Region: AAA_31; pfam13614
176299010663	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299010664	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
176299010665	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299010666	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
176299010667	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
176299010668	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299010669	transcription elongation factor regulatory protein; Validated; Region: PRK06342
176299010670	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
176299010671	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
176299010672	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
176299010673	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
176299010674	active site
176299010675	catalytic residues [active]
176299010676	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299010677	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
176299010678	AP (apurinic/apyrimidinic) site pocket; other site
176299010679	DNA interaction; other site
176299010680	Metal-binding active site; metal-binding site
176299010681	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
176299010682	invasion protein regulator; Provisional; Region: PRK12370
176299010683	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299010684	TPR motif; other site
176299010685	binding surface
176299010686	Uncharacterized conserved protein [Function unknown]; Region: COG1944
176299010687	Uncharacterized conserved protein [Function unknown]; Region: COG3482
176299010688	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299010689	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299010690	non-specific DNA binding site [nucleotide binding]; other site
176299010691	salt bridge; other site
176299010692	sequence-specific DNA binding site [nucleotide binding]; other site
176299010693	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
176299010694	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299010695	Walker A/P-loop; other site
176299010696	ATP binding site [chemical binding]; other site
176299010697	Q-loop/lid; other site
176299010698	ABC transporter signature motif; other site
176299010699	Walker B; other site
176299010700	D-loop; other site
176299010701	H-loop/switch region; other site
176299010702	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299010703	TM-ABC transporter signature motif; other site
176299010704	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
176299010705	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
176299010706	putative ligand binding site [chemical binding]; other site
176299010707	putative switch regulator; other site
176299010708	non-specific DNA interactions [nucleotide binding]; other site
176299010709	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
176299010710	DNA binding site [nucleotide binding]
176299010711	sequence specific DNA binding site [nucleotide binding]; other site
176299010712	putative cAMP binding site [chemical binding]; other site
176299010713	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299010714	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
176299010715	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
176299010716	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
176299010717	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
176299010718	dimer interface [polypeptide binding]; other site
176299010719	substrate binding site [chemical binding]; other site
176299010720	metal binding site [ion binding]; metal-binding site
176299010721	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
176299010722	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
176299010723	active site
176299010724	substrate binding site [chemical binding]; other site
176299010725	coenzyme B12 binding site [chemical binding]; other site
176299010726	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
176299010727	B12 binding site [chemical binding]; other site
176299010728	cobalt ligand [ion binding]; other site
176299010729	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
176299010730	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299010731	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
176299010732	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
176299010733	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
176299010734	carboxyltransferase (CT) interaction site; other site
176299010735	biotinylation site [posttranslational modification]; other site
176299010736	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
176299010737	putative S-transferase; Provisional; Region: PRK11752
176299010738	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
176299010739	C-terminal domain interface [polypeptide binding]; other site
176299010740	GSH binding site (G-site) [chemical binding]; other site
176299010741	dimer interface [polypeptide binding]; other site
176299010742	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
176299010743	dimer interface [polypeptide binding]; other site
176299010744	N-terminal domain interface [polypeptide binding]; other site
176299010745	active site
176299010746	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
176299010747	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
176299010748	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
176299010749	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299010750	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299010751	non-specific DNA binding site [nucleotide binding]; other site
176299010752	salt bridge; other site
176299010753	sequence-specific DNA binding site [nucleotide binding]; other site
176299010754	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
176299010755	Domain of unknown function (DUF955); Region: DUF955; pfam06114
176299010756	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
176299010757	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
176299010758	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
176299010759	minor groove reading motif; other site
176299010760	helix-hairpin-helix signature motif; other site
176299010761	substrate binding pocket [chemical binding]; other site
176299010762	active site
176299010763	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
176299010764	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
176299010765	active site
176299010766	nucleotide binding site [chemical binding]; other site
176299010767	HIGH motif; other site
176299010768	KMSKS motif; other site
176299010769	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
176299010770	short chain dehydrogenase; Validated; Region: PRK06182
176299010771	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
176299010772	NADP binding site [chemical binding]; other site
176299010773	active site
176299010774	steroid binding site; other site
176299010775	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
176299010776	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
176299010777	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
176299010778	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
176299010779	Ligand binding site [chemical binding]; other site
176299010780	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
176299010781	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
176299010782	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
176299010783	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
176299010784	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
176299010785	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
176299010786	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
176299010787	catalytic residues [active]
176299010788	argininosuccinate lyase; Provisional; Region: PRK00855
176299010789	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
176299010790	active sites [active]
176299010791	tetramer interface [polypeptide binding]; other site
176299010792	Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627
176299010793	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
176299010794	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
176299010795	active site
176299010796	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299010797	substrate binding site [chemical binding]; other site
176299010798	catalytic residues [active]
176299010799	dimer interface [polypeptide binding]; other site
176299010800	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
176299010801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299010802	active site
176299010803	phosphorylation site [posttranslational modification]
176299010804	intermolecular recognition site; other site
176299010805	dimerization interface [polypeptide binding]; other site
176299010806	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299010807	active site
176299010808	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
176299010809	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
176299010810	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299010811	Walker A/P-loop; other site
176299010812	ATP binding site [chemical binding]; other site
176299010813	Q-loop/lid; other site
176299010814	ABC transporter signature motif; other site
176299010815	Walker B; other site
176299010816	D-loop; other site
176299010817	H-loop/switch region; other site
176299010818	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
176299010819	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
176299010820	putative active site [active]
176299010821	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
176299010822	putative acyl-acceptor binding pocket; other site
176299010823	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
176299010824	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
176299010825	putative active site pocket [active]
176299010826	dimerization interface [polypeptide binding]; other site
176299010827	putative catalytic residue [active]
176299010828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
176299010829	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
176299010830	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
176299010831	prephenate dehydrogenase; Validated; Region: PRK08507
176299010832	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
176299010833	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299010834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299010835	homodimer interface [polypeptide binding]; other site
176299010836	catalytic residue [active]
176299010837	Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847
176299010838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299010839	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
176299010840	Uncharacterized conserved protein [Function unknown]; Region: COG3542
176299010841	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
176299010842	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
176299010843	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
176299010844	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
176299010845	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
176299010846	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
176299010847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
176299010848	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
176299010849	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) [Coenzyme metabolism]; Region: CobT; COG4547
176299010850	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
176299010851	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
176299010852	metal ion-dependent adhesion site (MIDAS); other site
176299010853	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
176299010854	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
176299010855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944
176299010856	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
176299010857	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
176299010858	HSP70 interaction site [polypeptide binding]; other site
176299010859	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
176299010860	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
176299010861	active site
176299010862	dimer interface [polypeptide binding]; other site
176299010863	metal binding site [ion binding]; metal-binding site
176299010864	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
176299010865	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
176299010866	ADP binding site [chemical binding]; other site
176299010867	magnesium binding site [ion binding]; other site
176299010868	putative shikimate binding site; other site
176299010869	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
176299010870	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
176299010871	active site
176299010872	DNA binding site [nucleotide binding]
176299010873	Int/Topo IB signature motif; other site
176299010874	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
176299010875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
176299010876	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
176299010877	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
176299010878	CPxP  motif; other site
176299010879	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
176299010880	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299010881	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299010882	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
176299010883	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
176299010884	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
176299010885	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
176299010886	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
176299010887	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
176299010888	metal binding site [ion binding]; metal-binding site
176299010889	putative dimer interface [polypeptide binding]; other site
176299010890	Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828
176299010891	Uncharacterized conserved protein [Function unknown]; Region: COG5620
176299010892	GAD-like domain; Region: GAD-like; pfam08887
176299010893	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
176299010894	Domain of unknown function (DUF4150); Region: DUF4150; pfam13665
176299010895	Putative toxin 43; Region: Toxin_43; pfam15604
176299010896	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5351
176299010897	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
176299010898	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
176299010899	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
176299010900	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
176299010901	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943
176299010902	PemK-like protein; Region: PemK; cl00995
176299010903	Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435
176299010904	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299010905	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299010906	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
176299010907	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299010908	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299010909	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
176299010910	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
176299010911	catalytic triad [active]
176299010912	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299010913	Coenzyme A binding pocket [chemical binding]; other site
176299010914	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
176299010915	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
176299010916	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
176299010917	DNA binding residues [nucleotide binding]
176299010918	dimer interface [polypeptide binding]; other site
176299010919	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
176299010920	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299010921	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299010922	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299010923	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299010924	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
176299010925	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299010926	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299010927	classical (c) SDRs; Region: SDR_c; cd05233
176299010928	NAD(P) binding site [chemical binding]; other site
176299010929	active site
176299010930	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299010931	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
176299010932	tetramerization interface [polypeptide binding]; other site
176299010933	active site
176299010934	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299010935	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299010936	putative efflux protein, MATE family; Region: matE; TIGR00797
176299010937	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
176299010938	Condensation domain; Region: Condensation; pfam00668
176299010939	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
176299010940	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
176299010941	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
176299010942	acyl-activating enzyme (AAE) consensus motif; other site
176299010943	AMP binding site [chemical binding]; other site
176299010944	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299010945	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
176299010946	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
176299010947	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
176299010948	active site
176299010949	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
176299010950	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
176299010951	putative NADP binding site [chemical binding]; other site
176299010952	active site
176299010953	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299010954	acyl-CoA synthetase; Validated; Region: PRK05850
176299010955	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
176299010956	acyl-activating enzyme (AAE) consensus motif; other site
176299010957	active site
176299010958	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
176299010959	Condensation domain; Region: Condensation; pfam00668
176299010960	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
176299010961	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
176299010962	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
176299010963	acyl-activating enzyme (AAE) consensus motif; other site
176299010964	AMP binding site [chemical binding]; other site
176299010965	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299010966	thioester reductase domain; Region: Thioester-redct; TIGR01746
176299010967	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
176299010968	putative NAD(P) binding site [chemical binding]; other site
176299010969	active site
176299010970	putative substrate binding site [chemical binding]; other site
176299010971	Methyltransferase domain; Region: Methyltransf_31; pfam13847
176299010972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299010973	S-adenosylmethionine binding site [chemical binding]; other site
176299010974	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
176299010975	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299010976	inhibitor-cofactor binding pocket; inhibition site
176299010977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299010978	catalytic residue [active]
176299010979	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
176299010980	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
176299010981	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
176299010982	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
176299010983	active site
176299010984	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
176299010985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299010986	short chain dehydrogenase; Region: adh_short; pfam00106
176299010987	NAD(P) binding site [chemical binding]; other site
176299010988	active site
176299010989	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299010990	Condensation domain; Region: Condensation; pfam00668
176299010991	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
176299010992	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
176299010993	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
176299010994	acyl-activating enzyme (AAE) consensus motif; other site
176299010995	AMP binding site [chemical binding]; other site
176299010996	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299010997	Condensation domain; Region: Condensation; cl19241
176299010998	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
176299010999	Nonribosomal peptide synthase; Region: NRPS; pfam08415
176299011000	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
176299011001	acyl-activating enzyme (AAE) consensus motif; other site
176299011002	AMP binding site [chemical binding]; other site
176299011003	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
176299011004	putative FMN binding site [chemical binding]; other site
176299011005	NADPH bind site [chemical binding]; other site
176299011006	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
176299011007	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299011008	Condensation domain; Region: Condensation; pfam00668
176299011009	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
176299011010	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
176299011011	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
176299011012	acyl-activating enzyme (AAE) consensus motif; other site
176299011013	AMP binding site [chemical binding]; other site
176299011014	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299011015	Condensation domain; Region: Condensation; pfam00668
176299011016	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
176299011017	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
176299011018	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
176299011019	acyl-activating enzyme (AAE) consensus motif; other site
176299011020	AMP binding site [chemical binding]; other site
176299011021	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299011022	Condensation domain; Region: Condensation; cl19241
176299011023	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
176299011024	Condensation domain; Region: Condensation; pfam00668
176299011025	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
176299011026	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
176299011027	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299011028	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
176299011029	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
176299011030	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
176299011031	Secretin and TonB N terminus short domain; Region: STN; smart00965
176299011032	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
176299011033	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
176299011034	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
176299011035	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
176299011036	siderophore binding site; other site
176299011037	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299011038	ABC-ATPase subunit  interface; other site
176299011039	dimer interface [polypeptide binding]; other site
176299011040	putative PBP binding regions; other site
176299011041	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299011042	ABC-ATPase subunit  interface; other site
176299011043	dimer interface [polypeptide binding]; other site
176299011044	putative PBP binding regions; other site
176299011045	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
176299011046	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
176299011047	Walker A/P-loop; other site
176299011048	ATP binding site [chemical binding]; other site
176299011049	Q-loop/lid; other site
176299011050	ABC transporter signature motif; other site
176299011051	Walker B; other site
176299011052	D-loop; other site
176299011053	H-loop/switch region; other site
176299011054	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
176299011055	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
176299011056	DNA binding residues [nucleotide binding]
176299011057	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
176299011058	FecR protein; Region: FecR; pfam04773
176299011059	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
176299011060	Transglycosylase; Region: Transgly; pfam00912
176299011061	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
176299011062	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
176299011063	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
176299011064	putative binding site; other site
176299011065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299011066	binding surface
176299011067	TPR motif; other site
176299011068	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
176299011069	MG2 domain; Region: A2M_N; pfam01835
176299011070	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
176299011071	Alpha-2-macroglobulin family; Region: A2M; pfam00207
176299011072	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
176299011073	surface patch; other site
176299011074	thioester region; other site
176299011075	specificity defining residues; other site
176299011076	Uncharacterized conserved protein [Function unknown]; Region: COG2835
176299011077	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
176299011078	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
176299011079	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
176299011080	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299011081	binding surface
176299011082	TPR motif; other site
176299011083	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
176299011084	putative deacylase active site [active]
176299011085	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
176299011086	putative C-terminal domain interface [polypeptide binding]; other site
176299011087	putative GSH binding site (G-site) [chemical binding]; other site
176299011088	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299011089	putative dimer interface [polypeptide binding]; other site
176299011090	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
176299011091	dimer interface [polypeptide binding]; other site
176299011092	N-terminal domain interface [polypeptide binding]; other site
176299011093	putative substrate binding pocket (H-site) [chemical binding]; other site
176299011094	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
176299011095	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
176299011096	Ligand Binding Site [chemical binding]; other site
176299011097	OpgC protein; Region: OpgC_C; cl17858
176299011098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395
176299011099	Tim44-like domain; Region: Tim44; pfam04280
176299011100	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
176299011101	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
176299011102	ligand binding site [chemical binding]; other site
176299011103	NAD binding site [chemical binding]; other site
176299011104	dimerization interface [polypeptide binding]; other site
176299011105	catalytic site [active]
176299011106	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
176299011107	putative L-serine binding site [chemical binding]; other site
176299011108	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
176299011109	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299011110	catalytic residue [active]
176299011111	serC leader; predicted by RFAM
176299011112	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
176299011113	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
176299011114	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
176299011115	active site
176299011116	substrate binding site [chemical binding]; other site
176299011117	metal binding site [ion binding]; metal-binding site
176299011118	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
176299011119	FtsH Extracellular; Region: FtsH_ext; pfam06480
176299011120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299011121	Walker A motif; other site
176299011122	ATP binding site [chemical binding]; other site
176299011123	Walker B motif; other site
176299011124	arginine finger; other site
176299011125	Peptidase family M41; Region: Peptidase_M41; pfam01434
176299011126	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
176299011127	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
176299011128	Ligand Binding Site [chemical binding]; other site
176299011129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
176299011130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299011131	binding surface
176299011132	TPR motif; other site
176299011133	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
176299011134	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
176299011135	ligand binding site [chemical binding]; other site
176299011136	translocation protein TolB; Provisional; Region: tolB; PRK05137
176299011137	TolB amino-terminal domain; Region: TolB_N; pfam04052
176299011138	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
176299011139	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
176299011140	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
176299011141	TolA protein; Region: tolA_full; TIGR02794
176299011142	Mid-1-related chloride channel (MCLC); Region: MCLC; pfam05934
176299011143	Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; cl10048
176299011144	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
176299011145	TolQ protein; Region: tolQ; TIGR02796
176299011146	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
176299011147	active site
176299011148	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
176299011149	nudix motif; other site
176299011150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
176299011151	Protein of unknown function (DUF2945); Region: DUF2945; pfam11160
176299011152	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
176299011153	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299011154	Walker A motif; other site
176299011155	ATP binding site [chemical binding]; other site
176299011156	Walker B motif; other site
176299011157	arginine finger; other site
176299011158	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
176299011159	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
176299011160	RuvA N terminal domain; Region: RuvA_N; pfam01330
176299011161	Helix-hairpin-helix domain; Region: HHH_5; pfam14520
176299011162	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
176299011163	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
176299011164	active site
176299011165	putative DNA-binding cleft [nucleotide binding]; other site
176299011166	dimer interface [polypeptide binding]; other site
176299011167	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299011168	dimerization interface [polypeptide binding]; other site
176299011169	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
176299011170	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299011171	dimer interface [polypeptide binding]; other site
176299011172	putative CheW interface [polypeptide binding]; other site
176299011173	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
176299011174	hypothetical protein; Validated; Region: PRK00110
176299011175	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
176299011176	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
176299011177	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
176299011178	putative active site [active]
176299011179	metal binding site [ion binding]; metal-binding site
176299011180	homodimer binding site [polypeptide binding]; other site
176299011181	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
176299011182	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
176299011183	Domain of unknown function DUF21; Region: DUF21; pfam01595
176299011184	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
176299011185	Transporter associated domain; Region: CorC_HlyC; smart01091
176299011186	Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division,    chromosome partitioning]; Region: zapA; COG3027
176299011187	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
176299011188	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
176299011189	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
176299011190	TPP-binding site [chemical binding]; other site
176299011191	dimer interface [polypeptide binding]; other site
176299011192	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
176299011193	PYR/PP interface [polypeptide binding]; other site
176299011194	dimer interface [polypeptide binding]; other site
176299011195	TPP binding site [chemical binding]; other site
176299011196	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
176299011197	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
176299011198	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
176299011199	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
176299011200	NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263
176299011201	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
176299011202	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
176299011203	substrate binding site [chemical binding]; other site
176299011204	hinge regions; other site
176299011205	ADP binding site [chemical binding]; other site
176299011206	catalytic site [active]
176299011207	Fructose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: COG3588
176299011208	catalytic residue [active]
176299011209	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299011210	putative substrate translocation pore; other site
176299011211	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299011212	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5317
176299011213	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
176299011214	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
176299011215	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299011216	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299011217	Walker A/P-loop; other site
176299011218	ATP binding site [chemical binding]; other site
176299011219	Q-loop/lid; other site
176299011220	ABC transporter signature motif; other site
176299011221	Walker B; other site
176299011222	D-loop; other site
176299011223	H-loop/switch region; other site
176299011224	Predicted oxidoreductase [General function prediction only]; Region: COG3573
176299011225	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
176299011226	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
176299011227	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
176299011228	ligand binding site [chemical binding]; other site
176299011229	lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764
176299011230	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
176299011231	active site
176299011232	dimerization interface [polypeptide binding]; other site
176299011233	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
176299011234	Sel1-like repeats; Region: SEL1; smart00671
176299011235	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
176299011236	thiamine phosphate binding site [chemical binding]; other site
176299011237	active site
176299011238	pyrophosphate binding site [ion binding]; other site
176299011239	Predicted permeases [General function prediction only]; Region: COG0730
176299011240	Protein of unknown function (DUF465); Region: DUF465; cl01070
176299011241	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
176299011242	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
176299011243	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
176299011244	ATP-grasp domain; Region: ATP-grasp; pfam02222
176299011245	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
176299011246	TPR repeat; Region: TPR_11; pfam13414
176299011247	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299011248	TPR motif; other site
176299011249	binding surface
176299011250	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3750
176299011251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492
176299011252	Predicted N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: COG3931
176299011253	Predicted integral membrane protein [Function unknown]; Region: COG5480
176299011254	pyruvate kinase; Provisional; Region: PRK06247
176299011255	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
176299011256	domain interfaces; other site
176299011257	active site
176299011258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
176299011259	Bacterial protein of unknown function (DUF882); Region: Peptidase_M15_2; pfam05951
176299011260	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
176299011261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299011262	active site
176299011263	phosphorylation site [posttranslational modification]
176299011264	intermolecular recognition site; other site
176299011265	dimerization interface [polypeptide binding]; other site
176299011266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299011267	Walker A motif; other site
176299011268	ATP binding site [chemical binding]; other site
176299011269	Walker B motif; other site
176299011270	arginine finger; other site
176299011271	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
176299011272	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
176299011273	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
176299011274	active site
176299011275	Zn binding site [ion binding]; other site
176299011276	hypothetical protein; Provisional; Region: PRK07546
176299011277	substrate-cofactor binding pocket; other site
176299011278	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299011279	homodimer interface [polypeptide binding]; other site
176299011280	catalytic residue [active]
176299011281	PAS fold; Region: PAS_7; pfam12860
176299011282	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299011283	metal binding site [ion binding]; metal-binding site
176299011284	active site
176299011285	I-site; other site
176299011286	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
176299011287	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
176299011288	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
176299011289	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
176299011290	active site
176299011291	metal binding site [ion binding]; metal-binding site
176299011292	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
176299011293	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
176299011294	ferrochelatase; Reviewed; Region: hemH; PRK00035
176299011295	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
176299011296	C-terminal domain interface [polypeptide binding]; other site
176299011297	active site
176299011298	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
176299011299	active site
176299011300	N-terminal domain interface [polypeptide binding]; other site
176299011301	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
176299011302	Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829
176299011303	core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
176299011304	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
176299011305	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
176299011306	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
176299011307	putative active site [active]
176299011308	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
176299011309	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299011310	putative active site [active]
176299011311	heme pocket [chemical binding]; other site
176299011312	PAS fold; Region: PAS_3; pfam08447
176299011313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5338
176299011314	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
176299011315	active site
176299011316	tetramer interface; other site
176299011317	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
176299011318	Transglycosylase SLT domain; Region: SLT_2; pfam13406
176299011319	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
176299011320	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
176299011321	active site
176299011322	catalytic triad [active]
176299011323	oxyanion hole [active]
176299011324	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299011325	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299011326	active site
176299011327	phosphorylation site [posttranslational modification]
176299011328	intermolecular recognition site; other site
176299011329	dimerization interface [polypeptide binding]; other site
176299011330	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299011331	DNA binding site [nucleotide binding]
176299011332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299011333	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299011334	dimer interface [polypeptide binding]; other site
176299011335	phosphorylation site [posttranslational modification]
176299011336	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299011337	ATP binding site [chemical binding]; other site
176299011338	Mg2+ binding site [ion binding]; other site
176299011339	G-X-G motif; other site
176299011340	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
176299011341	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
176299011342	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299011343	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
176299011344	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
176299011345	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
176299011346	active site
176299011347	dimer interface [polypeptide binding]; other site
176299011348	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
176299011349	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
176299011350	active site
176299011351	FMN binding site [chemical binding]; other site
176299011352	substrate binding site [chemical binding]; other site
176299011353	3Fe-4S cluster binding site [ion binding]; other site
176299011354	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
176299011355	domain interface; other site
176299011356	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
176299011357	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
176299011358	tetramer interface [polypeptide binding]; other site
176299011359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299011360	catalytic residue [active]
176299011361	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299011362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299011363	active site
176299011364	phosphorylation site [posttranslational modification]
176299011365	intermolecular recognition site; other site
176299011366	dimerization interface [polypeptide binding]; other site
176299011367	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299011368	DNA binding site [nucleotide binding]
176299011369	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
176299011370	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
176299011371	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
176299011372	Ligand Binding Site [chemical binding]; other site
176299011373	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
176299011374	GAF domain; Region: GAF_3; pfam13492
176299011375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299011376	dimer interface [polypeptide binding]; other site
176299011377	phosphorylation site [posttranslational modification]
176299011378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299011379	ATP binding site [chemical binding]; other site
176299011380	Mg2+ binding site [ion binding]; other site
176299011381	G-X-G motif; other site
176299011382	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
176299011383	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
176299011384	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
176299011385	haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
176299011386	Soluble P-type ATPase [General function prediction only]; Region: COG4087
176299011387	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
176299011388	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
176299011389	active site
176299011390	homotetramer interface [polypeptide binding]; other site
176299011391	homodimer interface [polypeptide binding]; other site
176299011392	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
176299011393	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
176299011394	Aspartase; Region: Aspartase; cd01357
176299011395	active sites [active]
176299011396	tetramer interface [polypeptide binding]; other site
176299011397	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299011398	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299011399	DNA-binding site [nucleotide binding]; DNA binding site
176299011400	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299011401	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299011402	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
176299011403	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299011404	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299011405	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299011406	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299011407	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299011408	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299011409	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299011410	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299011411	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299011412	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
176299011413	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299011414	DNA-binding site [nucleotide binding]; DNA binding site
176299011415	UTRA domain; Region: UTRA; pfam07702
176299011416	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
176299011417	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299011418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011419	dimer interface [polypeptide binding]; other site
176299011420	conserved gate region; other site
176299011421	putative PBP binding loops; other site
176299011422	ABC-ATPase subunit interface; other site
176299011423	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299011424	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
176299011425	Walker A/P-loop; other site
176299011426	ATP binding site [chemical binding]; other site
176299011427	Q-loop/lid; other site
176299011428	ABC transporter signature motif; other site
176299011429	Walker B; other site
176299011430	D-loop; other site
176299011431	H-loop/switch region; other site
176299011432	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
176299011433	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
176299011434	active sites [active]
176299011435	tetramer interface [polypeptide binding]; other site
176299011436	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
176299011437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299011438	putative substrate translocation pore; other site
176299011439	Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286
176299011440	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
176299011441	homodimer interface [polypeptide binding]; other site
176299011442	substrate-cofactor binding pocket; other site
176299011443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299011444	catalytic residue [active]
176299011445	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299011446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299011447	putative Zn2+ binding site [ion binding]; other site
176299011448	AsnC family; Region: AsnC_trans_reg; pfam01037
176299011449	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011450	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011451	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
176299011452	putative effector binding pocket; other site
176299011453	putative dimerization interface [polypeptide binding]; other site
176299011454	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299011455	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299011456	active site
176299011457	catalytic tetrad [active]
176299011458	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011459	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011460	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299011461	putative effector binding pocket; other site
176299011462	dimerization interface [polypeptide binding]; other site
176299011463	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
176299011464	catalytic triad [active]
176299011465	dimer interface [polypeptide binding]; other site
176299011466	conserved cis-peptide bond; other site
176299011467	Predicted small integral membrane protein [Function unknown]; Region: COG5478
176299011468	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299011469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299011470	NAD(P) binding site [chemical binding]; other site
176299011471	active site
176299011472	Uncharacterized conserved protein [Function unknown]; Region: COG3254
176299011473	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299011474	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299011475	DNA-binding site [nucleotide binding]; DNA binding site
176299011476	FCD domain; Region: FCD; pfam07729
176299011477	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299011478	active site
176299011479	catalytic tetrad [active]
176299011480	galactarate dehydratase; Region: galactar-dH20; TIGR03248
176299011481	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
176299011482	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
176299011483	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299011484	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299011485	Walker A/P-loop; other site
176299011486	ATP binding site [chemical binding]; other site
176299011487	Q-loop/lid; other site
176299011488	ABC transporter signature motif; other site
176299011489	Walker B; other site
176299011490	D-loop; other site
176299011491	H-loop/switch region; other site
176299011492	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299011493	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299011494	TM-ABC transporter signature motif; other site
176299011495	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299011496	TM-ABC transporter signature motif; other site
176299011497	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299011498	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317
176299011499	putative ligand binding site [chemical binding]; other site
176299011500	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
176299011501	substrate binding site [chemical binding]; other site
176299011502	THF binding site; other site
176299011503	zinc-binding site [ion binding]; other site
176299011504	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
176299011505	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
176299011506	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
176299011507	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
176299011508	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011509	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
176299011510	putative dimerization interface [polypeptide binding]; other site
176299011511	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299011512	Coenzyme A binding pocket [chemical binding]; other site
176299011513	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011514	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011515	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299011516	dimerization interface [polypeptide binding]; other site
176299011517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299011518	putative substrate translocation pore; other site
176299011519	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299011520	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
176299011521	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
176299011522	active site
176299011523	Int/Topo IB signature motif; other site
176299011524	reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612
176299011525	TIGR04255 family protein; Region: sporadTIGR04255
176299011526	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
176299011527	active site
176299011528	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
176299011529	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
176299011530	catalytic residues [active]
176299011531	catalytic nucleophile [active]
176299011532	Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393
176299011533	Helix-turn-helix domain; Region: HTH_17; pfam12728
176299011534	Protein of unknown function (DUF2465); Region: DUF2465; pfam10239
176299011535	AAA domain; Region: AAA_25; pfam13481
176299011536	Walker A motif; other site
176299011537	ATP binding site [chemical binding]; other site
176299011538	Walker B motif; other site
176299011539	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
176299011540	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
176299011541	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
176299011542	Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968
176299011543	putative active site [active]
176299011544	putative metal binding site [ion binding]; other site
176299011545	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
176299011546	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
176299011547	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
176299011548	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
176299011549	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
176299011550	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
176299011551	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
176299011552	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
176299011553	Uncharacterized conserved protein [Function unknown]; Region: COG2308
176299011554	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
176299011555	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
176299011556	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
176299011557	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
176299011558	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
176299011559	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
176299011560	metal ion-dependent adhesion site (MIDAS); other site
176299011561	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
176299011562	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299011563	ABC transporter; Region: ABC_tran_2; pfam12848
176299011564	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299011565	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
176299011566	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
176299011567	putative ligand binding site [chemical binding]; other site
176299011568	putative NAD binding site [chemical binding]; other site
176299011569	catalytic site [active]
176299011570	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
176299011571	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
176299011572	active site
176299011573	substrate binding site [chemical binding]; other site
176299011574	FMN binding site [chemical binding]; other site
176299011575	putative catalytic residues [active]
176299011576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299011577	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299011578	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299011579	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
176299011580	L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802
176299011581	putative N- and C-terminal domain interface [polypeptide binding]; other site
176299011582	putative active site [active]
176299011583	MgATP binding site [chemical binding]; other site
176299011584	catalytic site [active]
176299011585	metal binding site [ion binding]; metal-binding site
176299011586	putative xylulose binding site [chemical binding]; other site
176299011587	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
176299011588	putative active site; other site
176299011589	catalytic residue [active]
176299011590	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
176299011591	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299011592	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299011593	active site
176299011594	catalytic tetrad [active]
176299011595	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
176299011596	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299011597	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
176299011598	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299011599	TM-ABC transporter signature motif; other site
176299011600	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299011601	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299011602	Walker A/P-loop; other site
176299011603	ATP binding site [chemical binding]; other site
176299011604	Q-loop/lid; other site
176299011605	ABC transporter signature motif; other site
176299011606	Walker B; other site
176299011607	D-loop; other site
176299011608	H-loop/switch region; other site
176299011609	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299011610	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
176299011611	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299011612	ligand binding site [chemical binding]; other site
176299011613	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299011614	active site
176299011615	phosphorylation site [posttranslational modification]
176299011616	intermolecular recognition site; other site
176299011617	dimerization interface [polypeptide binding]; other site
176299011618	N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741
176299011619	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
176299011620	active site
176299011621	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
176299011622	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
176299011623	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
176299011624	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
176299011625	putative dimer interface [polypeptide binding]; other site
176299011626	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
176299011627	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011628	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011629	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299011630	dimerization interface [polypeptide binding]; other site
176299011631	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
176299011632	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
176299011633	N- and C-terminal domain interface [polypeptide binding]; other site
176299011634	active site
176299011635	MgATP binding site [chemical binding]; other site
176299011636	catalytic site [active]
176299011637	metal binding site [ion binding]; metal-binding site
176299011638	glycerol binding site [chemical binding]; other site
176299011639	homotetramer interface [polypeptide binding]; other site
176299011640	homodimer interface [polypeptide binding]; other site
176299011641	FBP binding site [chemical binding]; other site
176299011642	protein IIAGlc interface [polypeptide binding]; other site
176299011643	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299011644	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299011645	Predicted small integral membrane protein [Function unknown]; Region: COG5477
176299011646	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299011647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011648	dimer interface [polypeptide binding]; other site
176299011649	conserved gate region; other site
176299011650	putative PBP binding loops; other site
176299011651	ABC-ATPase subunit interface; other site
176299011652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011653	dimer interface [polypeptide binding]; other site
176299011654	conserved gate region; other site
176299011655	putative PBP binding loops; other site
176299011656	ABC-ATPase subunit interface; other site
176299011657	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299011658	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
176299011659	Walker A/P-loop; other site
176299011660	ATP binding site [chemical binding]; other site
176299011661	Q-loop/lid; other site
176299011662	ABC transporter signature motif; other site
176299011663	Walker B; other site
176299011664	D-loop; other site
176299011665	H-loop/switch region; other site
176299011666	TOBE domain; Region: TOBE_2; pfam08402
176299011667	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299011668	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
176299011669	Walker A/P-loop; other site
176299011670	ATP binding site [chemical binding]; other site
176299011671	Q-loop/lid; other site
176299011672	ABC transporter signature motif; other site
176299011673	Walker B; other site
176299011674	D-loop; other site
176299011675	H-loop/switch region; other site
176299011676	FAD dependent oxidoreductase; Region: DAO; pfam01266
176299011677	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
176299011678	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
176299011679	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
176299011680	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
176299011681	siroheme synthase; Provisional; Region: cysG; PRK10637
176299011682	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
176299011683	Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414
176299011684	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
176299011685	active site
176299011686	SAM binding site [chemical binding]; other site
176299011687	homodimer interface [polypeptide binding]; other site
176299011688	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
176299011689	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
176299011690	[4Fe-4S] binding site [ion binding]; other site
176299011691	molybdopterin cofactor binding site; other site
176299011692	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
176299011693	molybdopterin cofactor binding site; other site
176299011694	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
176299011695	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
176299011696	[2Fe-2S] cluster binding site [ion binding]; other site
176299011697	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
176299011698	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299011699	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299011700	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
176299011701	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
176299011702	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
176299011703	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
176299011704	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299011705	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299011706	Walker A/P-loop; other site
176299011707	ATP binding site [chemical binding]; other site
176299011708	Q-loop/lid; other site
176299011709	ABC transporter signature motif; other site
176299011710	Walker B; other site
176299011711	D-loop; other site
176299011712	H-loop/switch region; other site
176299011713	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299011714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011715	dimer interface [polypeptide binding]; other site
176299011716	conserved gate region; other site
176299011717	putative PBP binding loops; other site
176299011718	ABC-ATPase subunit interface; other site
176299011719	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299011720	NMT1-like family; Region: NMT1_2; pfam13379
176299011721	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299011722	NMT1-like family; Region: NMT1_2; pfam13379
176299011723	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
176299011724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299011725	active site
176299011726	phosphorylation site [posttranslational modification]
176299011727	intermolecular recognition site; other site
176299011728	ANTAR domain; Region: ANTAR; pfam03861
176299011729	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299011730	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299011731	DNA-binding site [nucleotide binding]; DNA binding site
176299011732	FCD domain; Region: FCD; pfam07729
176299011733	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
176299011734	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
176299011735	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
176299011736	putative active site [active]
176299011737	hypothetical protein; Provisional; Region: PRK05463
176299011738	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
176299011739	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
176299011740	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
176299011741	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299011742	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299011743	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
176299011744	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
176299011745	carboxyltransferase (CT) interaction site; other site
176299011746	biotinylation site [posttranslational modification]; other site
176299011747	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
176299011748	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
176299011749	active site
176299011750	Na/Ca binding site [ion binding]; other site
176299011751	catalytic site [active]
176299011752	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
176299011753	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
176299011754	DNA binding residues [nucleotide binding]
176299011755	dimer interface [polypeptide binding]; other site
176299011756	[2Fe-2S] cluster binding site [ion binding]; other site
176299011757	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
176299011758	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
176299011759	N-terminal plug; other site
176299011760	ligand-binding site [chemical binding]; other site
176299011761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011762	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011763	hypothetical protein; Validated; Region: PRK09071
176299011764	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
176299011765	Predicted membrane protein [Function unknown]; Region: COG4292
176299011766	replication initiation protein RepC; Provisional; Region: PRK13824
176299011767	Replication protein C N-terminal domain; Region: RP-C; pfam03428
176299011768	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299011769	putative DNA binding site [nucleotide binding]; other site
176299011770	putative Zn2+ binding site [ion binding]; other site
176299011771	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
176299011772	S-element; predicted by RFAM
176299011773	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
176299011774	ParB-like nuclease domain; Region: ParBc; pfam02195
176299011775	RepB plasmid partitioning protein; Region: RepB; pfam07506
176299011776	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
176299011777	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
176299011778	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299011779	P-loop; other site
176299011780	Magnesium ion binding site [ion binding]; other site
176299011781	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
176299011782	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
176299011783	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
176299011784	homotrimer interaction site [polypeptide binding]; other site
176299011785	putative active site [active]
176299011786	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
176299011787	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
176299011788	dimer interface [polypeptide binding]; other site
176299011789	active site
176299011790	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299011791	substrate binding site [chemical binding]; other site
176299011792	catalytic residue [active]
176299011793	Uncharacterized conserved protein [Function unknown]; Region: COG5476
176299011794	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
176299011795	MlrC C-terminus; Region: MlrC_C; pfam07171
176299011796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3758
176299011797	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299011798	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299011799	urocanate hydratase; Provisional; Region: PRK05414
176299011800	N-formylglutamate amidohydrolase; Region: FGase; cl01522
176299011801	Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221
176299011802	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
176299011803	active sites [active]
176299011804	tetramer interface [polypeptide binding]; other site
176299011805	imidazolonepropionase; Validated; Region: PRK09356
176299011806	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
176299011807	active site
176299011808	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
176299011809	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
176299011810	active site
176299011811	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299011812	DNA-binding site [nucleotide binding]; DNA binding site
176299011813	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
176299011814	UTRA domain; Region: UTRA; pfam07702
176299011815	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299011816	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299011817	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
176299011818	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
176299011819	dimer interface [polypeptide binding]; other site
176299011820	active site
176299011821	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299011822	substrate binding site [chemical binding]; other site
176299011823	catalytic residue [active]
176299011824	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
176299011825	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124
176299011826	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
176299011827	NAD binding site [chemical binding]; other site
176299011828	catalytic residues [active]
176299011829	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011830	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011831	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
176299011832	putative effector binding pocket; other site
176299011833	putative dimerization interface [polypeptide binding]; other site
176299011834	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299011835	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299011836	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
176299011837	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
176299011838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011839	dimer interface [polypeptide binding]; other site
176299011840	conserved gate region; other site
176299011841	putative PBP binding loops; other site
176299011842	ABC-ATPase subunit interface; other site
176299011843	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299011844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011845	dimer interface [polypeptide binding]; other site
176299011846	conserved gate region; other site
176299011847	putative PBP binding loops; other site
176299011848	ABC-ATPase subunit interface; other site
176299011849	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
176299011850	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
176299011851	Walker A/P-loop; other site
176299011852	ATP binding site [chemical binding]; other site
176299011853	Q-loop/lid; other site
176299011854	ABC transporter signature motif; other site
176299011855	Walker B; other site
176299011856	D-loop; other site
176299011857	H-loop/switch region; other site
176299011858	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
176299011859	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
176299011860	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299011861	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299011862	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299011863	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
176299011864	NAD(P) binding site [chemical binding]; other site
176299011865	catalytic residues [active]
176299011866	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299011867	inhibitor site; inhibition site
176299011868	active site
176299011869	dimer interface [polypeptide binding]; other site
176299011870	catalytic residue [active]
176299011871	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299011872	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299011873	DNA-binding site [nucleotide binding]; DNA binding site
176299011874	FCD domain; Region: FCD; pfam07729
176299011875	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
176299011876	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299011877	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299011878	DNA-binding site [nucleotide binding]; DNA binding site
176299011879	FCD domain; Region: FCD; pfam07729
176299011880	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299011881	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299011882	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299011883	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299011884	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299011885	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299011886	Putative FMN-binding domain; Region: FMN_bind_2; cl17803
176299011887	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299011888	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299011889	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299011890	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299011891	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
176299011892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011893	dimer interface [polypeptide binding]; other site
176299011894	conserved gate region; other site
176299011895	putative PBP binding loops; other site
176299011896	ABC-ATPase subunit interface; other site
176299011897	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299011898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299011899	dimer interface [polypeptide binding]; other site
176299011900	conserved gate region; other site
176299011901	putative PBP binding loops; other site
176299011902	ABC-ATPase subunit interface; other site
176299011903	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299011904	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299011905	Walker A/P-loop; other site
176299011906	ATP binding site [chemical binding]; other site
176299011907	Q-loop/lid; other site
176299011908	ABC transporter signature motif; other site
176299011909	Walker B; other site
176299011910	D-loop; other site
176299011911	H-loop/switch region; other site
176299011912	TOBE domain; Region: TOBE_2; pfam08402
176299011913	dihydroxy-acid dehydratase; Provisional; Region: PRK13016
176299011914	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299011915	short chain dehydrogenase; Region: adh_short; pfam00106
176299011916	NAD(P) binding site [chemical binding]; other site
176299011917	active site
176299011918	hypothetical protein; Validated; Region: PRK08245
176299011919	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
176299011920	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
176299011921	UDP-galactopyranose mutase; Region: GLF; pfam03275
176299011922	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
176299011923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299011924	binding surface
176299011925	TPR motif; other site
176299011926	Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138
176299011927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011929	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299011930	putative effector binding pocket; other site
176299011931	dimerization interface [polypeptide binding]; other site
176299011932	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
176299011933	Zn binding site [ion binding]; other site
176299011934	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
176299011935	Zn binding site [ion binding]; other site
176299011936	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
176299011937	catalytic triad [active]
176299011938	dimer interface [polypeptide binding]; other site
176299011939	conserved cis-peptide bond; other site
176299011940	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4317
176299011941	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
176299011942	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
176299011943	active site
176299011944	Predicted membrane protein [Function unknown]; Region: COG2259
176299011945	Transmembrane secretion effector; Region: MFS_3; pfam05977
176299011946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299011947	putative substrate translocation pore; other site
176299011948	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
176299011949	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476
176299011950	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
176299011951	Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
176299011952	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
176299011953	active site
176299011954	catalytic site [active]
176299011955	substrate binding site [chemical binding]; other site
176299011956	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299011957	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299011958	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299011959	dimerization interface [polypeptide binding]; other site
176299011960	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
176299011961	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299011962	putative substrate translocation pore; other site
176299011963	Uncharacterized Cupredoxin-like subfamily; Region: Cupredoxin_like_2; cd04211
176299011964	putative Type 1 (T1) Cu binding site [ion binding]; other site
176299011965	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
176299011966	The first cupredoxin domain of bacteria two domain multicopper oxidase; Region: CuRO_1_2dMco_1; cd13860
176299011967	putative trimer interface [polypeptide binding]; other site
176299011968	trinuclear Cu binding site [ion binding]; other site
176299011969	The second cupredoxin domain of bacterial two domain multicopper oxidase McoN and similar proteins; Region: CuRO_D2_2dMcoN_like; cd04202
176299011970	trimer interface [polypeptide binding]; other site
176299011971	trinuclear Cu binding site [ion binding]; other site
176299011972	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
176299011973	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299011974	Outer membrane efflux protein; Region: OEP; pfam02321
176299011975	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
176299011976	Helix-turn-helix domain; Region: HTH_18; pfam12833
176299011977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299011978	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299011979	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299011980	Coenzyme A binding pocket [chemical binding]; other site
176299011981	biotin synthase; Region: bioB; TIGR00433
176299011982	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
176299011983	FeS/SAM binding site; other site
176299011984	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
176299011985	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
176299011986	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
176299011987	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299011988	catalytic residue [active]
176299011989	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
176299011990	AAA domain; Region: AAA_26; pfam13500
176299011991	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299011992	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299011993	inhibitor-cofactor binding pocket; inhibition site
176299011994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299011995	catalytic residue [active]
176299011996	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963
176299011997	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
176299011998	dimer interface [polypeptide binding]; other site
176299011999	active site
176299012000	CoA binding pocket [chemical binding]; other site
176299012001	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299012002	EamA-like transporter family; Region: EamA; pfam00892
176299012003	EamA-like transporter family; Region: EamA; pfam00892
176299012004	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
176299012005	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299012006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299012007	LysR substrate binding domain; Region: LysR_substrate; pfam03466
176299012008	dimerization interface [polypeptide binding]; other site
176299012009	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299012010	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299012011	Arginase family; Region: Arginase; cd09989
176299012012	active site
176299012013	Mn binding site [ion binding]; other site
176299012014	oligomer interface [polypeptide binding]; other site
176299012015	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299012016	Helix-turn-helix domain; Region: HTH_28; pfam13518
176299012017	putative transposase OrfB; Reviewed; Region: PHA02517
176299012018	HTH-like domain; Region: HTH_21; pfam13276
176299012019	Integrase core domain; Region: rve; pfam00665
176299012020	Integrase core domain; Region: rve_2; pfam13333
176299012021	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299012022	EamA-like transporter family; Region: EamA; pfam00892
176299012023	EamA-like transporter family; Region: EamA; pfam00892
176299012024	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299012025	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299012026	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299012027	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
176299012028	cyclase homology domain; Region: CHD; cd07302
176299012029	nucleotidyl binding site; other site
176299012030	metal binding site [ion binding]; metal-binding site
176299012031	dimer interface [polypeptide binding]; other site
176299012032	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299012033	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299012034	non-specific DNA binding site [nucleotide binding]; other site
176299012035	salt bridge; other site
176299012036	sequence-specific DNA binding site [nucleotide binding]; other site
176299012037	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
176299012038	HTH DNA binding domain; Region: HTH_13; pfam11972
176299012039	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
176299012040	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299012041	putative substrate translocation pore; other site
176299012042	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299012043	HAMP domain; Region: HAMP; pfam00672
176299012044	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299012045	dimer interface [polypeptide binding]; other site
176299012046	phosphorylation site [posttranslational modification]
176299012047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299012048	ATP binding site [chemical binding]; other site
176299012049	Mg2+ binding site [ion binding]; other site
176299012050	G-X-G motif; other site
176299012051	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299012052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299012053	active site
176299012054	phosphorylation site [posttranslational modification]
176299012055	intermolecular recognition site; other site
176299012056	dimerization interface [polypeptide binding]; other site
176299012057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299012058	DNA binding site [nucleotide binding]
176299012059	Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194
176299012060	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
176299012061	Sulfatase; Region: Sulfatase; pfam00884
176299012062	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
176299012063	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299012064	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
176299012065	dimerization interface [polypeptide binding]; other site
176299012066	substrate binding pocket [chemical binding]; other site
176299012067	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
176299012068	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
176299012069	N-terminal plug; other site
176299012070	ligand-binding site [chemical binding]; other site
176299012071	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
176299012072	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
176299012073	siderophore binding site; other site
176299012074	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
176299012075	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299012076	ABC-ATPase subunit  interface; other site
176299012077	dimer interface [polypeptide binding]; other site
176299012078	putative PBP binding regions; other site
176299012079	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299012080	ABC-ATPase subunit  interface; other site
176299012081	dimer interface [polypeptide binding]; other site
176299012082	putative PBP binding regions; other site
176299012083	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
176299012084	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
176299012085	Walker A/P-loop; other site
176299012086	ATP binding site [chemical binding]; other site
176299012087	Q-loop/lid; other site
176299012088	ABC transporter signature motif; other site
176299012089	Walker B; other site
176299012090	D-loop; other site
176299012091	H-loop/switch region; other site
176299012092	Protein of unknown function (DUF992); Region: DUF992; pfam06186
176299012093	Cytochrome c2 [Energy production and conversion]; Region: COG3474
176299012094	Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137
176299012095	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
176299012096	Strictosidine synthase; Region: Str_synth; cl19733
176299012097	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299012098	TM-ABC transporter signature motif; other site
176299012099	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299012100	TM-ABC transporter signature motif; other site
176299012101	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299012102	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299012103	Walker A/P-loop; other site
176299012104	ATP binding site [chemical binding]; other site
176299012105	Q-loop/lid; other site
176299012106	ABC transporter signature motif; other site
176299012107	Walker B; other site
176299012108	D-loop; other site
176299012109	H-loop/switch region; other site
176299012110	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299012111	Walker A/P-loop; other site
176299012112	ATP binding site [chemical binding]; other site
176299012113	Q-loop/lid; other site
176299012114	ABC transporter signature motif; other site
176299012115	Walker B; other site
176299012116	D-loop; other site
176299012117	H-loop/switch region; other site
176299012118	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299012119	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
176299012120	putative ligand binding site [chemical binding]; other site
176299012121	GAF domain; Region: GAF; pfam01590
176299012122	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
176299012123	Histidine kinase; Region: HisKA_3; pfam07730
176299012124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299012125	Mg2+ binding site [ion binding]; other site
176299012126	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299012127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299012128	active site
176299012129	phosphorylation site [posttranslational modification]
176299012130	intermolecular recognition site; other site
176299012131	dimerization interface [polypeptide binding]; other site
176299012132	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
176299012133	DNA binding residues [nucleotide binding]
176299012134	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
176299012135	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
176299012136	active site
176299012137	DNA binding site [nucleotide binding]
176299012138	Int/Topo IB signature motif; other site
176299012139	catalytic residues [active]
176299012140	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645
176299012141	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
176299012142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299012143	S-adenosylmethionine binding site [chemical binding]; other site
176299012144	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
176299012145	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
176299012146	active site
176299012147	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
176299012148	Uncharacterized conserved protein [Function unknown]; Region: COG1739
176299012149	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
176299012150	Predicted flavoproteins [General function prediction only]; Region: COG2081
176299012151	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299012152	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299012153	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
176299012154	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299012155	Walker A/P-loop; other site
176299012156	ATP binding site [chemical binding]; other site
176299012157	Q-loop/lid; other site
176299012158	ABC transporter signature motif; other site
176299012159	Walker B; other site
176299012160	D-loop; other site
176299012161	H-loop/switch region; other site
176299012162	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
176299012163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012164	dimer interface [polypeptide binding]; other site
176299012165	conserved gate region; other site
176299012166	putative PBP binding loops; other site
176299012167	ABC-ATPase subunit interface; other site
176299012168	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
176299012169	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299012170	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299012171	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299012172	putative active site [active]
176299012173	heme pocket [chemical binding]; other site
176299012174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299012175	putative active site [active]
176299012176	heme pocket [chemical binding]; other site
176299012177	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
176299012178	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
176299012179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299012180	dimer interface [polypeptide binding]; other site
176299012181	phosphorylation site [posttranslational modification]
176299012182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299012183	ATP binding site [chemical binding]; other site
176299012184	Mg2+ binding site [ion binding]; other site
176299012185	G-X-G motif; other site
176299012186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299012187	active site
176299012188	phosphorylation site [posttranslational modification]
176299012189	intermolecular recognition site; other site
176299012190	dimerization interface [polypeptide binding]; other site
176299012191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299012192	active site
176299012193	phosphorylation site [posttranslational modification]
176299012194	intermolecular recognition site; other site
176299012195	dimerization interface [polypeptide binding]; other site
176299012196	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299012197	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
176299012198	putative ligand binding site [chemical binding]; other site
176299012199	NAD binding site [chemical binding]; other site
176299012200	dimerization interface [polypeptide binding]; other site
176299012201	catalytic site [active]
176299012202	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
176299012203	Chain length determinant protein; Region: Wzz; pfam02706
176299012204	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
176299012205	AAA domain; Region: AAA_31; pfam13614
176299012206	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
176299012207	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
176299012208	active site
176299012209	tetramer interface; other site
176299012210	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
176299012211	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299012212	active site
176299012213	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
176299012214	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299012215	active site
176299012216	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299012217	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
176299012218	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
176299012219	Ligand binding site; other site
176299012220	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
176299012221	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
176299012222	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
176299012223	active site
176299012224	active site
176299012225	catalytic residues [active]
176299012226	Acyltransferase family; Region: Acyl_transf_3; pfam01757
176299012227	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
176299012228	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
176299012229	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
176299012230	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299012231	active site
176299012232	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
176299012233	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
176299012234	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299012235	active site
176299012236	Exopolysaccharide production repressor; Region: SyrA; pfam11089
176299012237	TPR repeat; Region: TPR_11; pfam13414
176299012238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299012239	TPR motif; other site
176299012240	binding surface
176299012241	TPR repeat; Region: TPR_11; pfam13414
176299012242	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299012243	binding surface
176299012244	TPR motif; other site
176299012245	TPR repeat; Region: TPR_11; pfam13414
176299012246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299012247	TPR repeat; Region: TPR_11; pfam13414
176299012248	binding surface
176299012249	TPR motif; other site
176299012250	Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828
176299012251	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
176299012252	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299012253	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
176299012254	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
176299012255	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
176299012256	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299012257	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
176299012258	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
176299012259	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
176299012260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4427
176299012261	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
176299012262	putative active site [active]
176299012263	putative catalytic site [active]
176299012264	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
176299012265	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
176299012266	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
176299012267	active site
176299012268	catalytic site [active]
176299012269	phosphoglucomutase; Region: PLN02307
176299012270	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
176299012271	substrate binding site [chemical binding]; other site
176299012272	dimer interface [polypeptide binding]; other site
176299012273	active site
176299012274	metal binding site [ion binding]; metal-binding site
176299012275	glycogen synthase; Provisional; Region: glgA; PRK00654
176299012276	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
176299012277	ADP-binding pocket [chemical binding]; other site
176299012278	homodimer interface [polypeptide binding]; other site
176299012279	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
176299012280	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
176299012281	ligand binding site; other site
176299012282	oligomer interface; other site
176299012283	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
176299012284	dimer interface [polypeptide binding]; other site
176299012285	N-terminal domain interface [polypeptide binding]; other site
176299012286	sulfate 1 binding site; other site
176299012287	glycogen branching enzyme; Provisional; Region: PRK05402
176299012288	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
176299012289	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
176299012290	active site
176299012291	catalytic site [active]
176299012292	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
176299012293	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
176299012294	homodimer interface [polypeptide binding]; other site
176299012295	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
176299012296	active site pocket [active]
176299012297	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
176299012298	putative active site [active]
176299012299	Glutamine amidotransferases class-II; Region: GATase_2; pfam00310
176299012300	putative dimer interface [polypeptide binding]; other site
176299012301	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
176299012302	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299012303	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299012304	putative DNA binding site [nucleotide binding]; other site
176299012305	putative Zn2+ binding site [ion binding]; other site
176299012306	AsnC family; Region: AsnC_trans_reg; pfam01037
176299012307	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
176299012308	active site
176299012309	catalytic residues [active]
176299012310	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
176299012311	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
176299012312	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
176299012313	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
176299012314	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
176299012315	NAD(P) binding site [chemical binding]; other site
176299012316	active site
176299012317	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
176299012318	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
176299012319	putative NAD(P) binding site [chemical binding]; other site
176299012320	catalytic Zn binding site [ion binding]; other site
176299012321	Predicted transcriptional regulators [Transcription]; Region: COG1510
176299012322	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299012323	dimerization interface [polypeptide binding]; other site
176299012324	putative Zn2+ binding site [ion binding]; other site
176299012325	putative DNA binding site [nucleotide binding]; other site
176299012326	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
176299012327	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299012328	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
176299012329	Walker A/P-loop; other site
176299012330	ATP binding site [chemical binding]; other site
176299012331	Q-loop/lid; other site
176299012332	ABC transporter signature motif; other site
176299012333	Walker B; other site
176299012334	D-loop; other site
176299012335	H-loop/switch region; other site
176299012336	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
176299012337	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299012338	Walker A/P-loop; other site
176299012339	ATP binding site [chemical binding]; other site
176299012340	Q-loop/lid; other site
176299012341	ABC transporter signature motif; other site
176299012342	Walker B; other site
176299012343	D-loop; other site
176299012344	H-loop/switch region; other site
176299012345	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
176299012346	Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219
176299012347	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
176299012348	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
176299012349	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
176299012350	Predicted membrane protein [Function unknown]; Region: COG2261
176299012351	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106
176299012352	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
176299012353	dimerization interface [polypeptide binding]; other site
176299012354	active site
176299012355	L-aspartate oxidase; Provisional; Region: PRK07512
176299012356	L-aspartate oxidase; Provisional; Region: PRK06175
176299012357	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
176299012358	quinolinate synthetase; Provisional; Region: PRK09375
176299012359	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
176299012360	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299012361	PAS fold; Region: PAS_3; pfam08447
176299012362	putative active site [active]
176299012363	heme pocket [chemical binding]; other site
176299012364	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
176299012365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
176299012366	cytidylate kinase; Provisional; Region: cmk; PRK00023
176299012367	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
176299012368	CMP-binding site; other site
176299012369	The sites determining sugar specificity; other site
176299012370	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
176299012371	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
176299012372	RNA binding site [nucleotide binding]; other site
176299012373	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
176299012374	RNA binding site [nucleotide binding]; other site
176299012375	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
176299012376	RNA binding site [nucleotide binding]; other site
176299012377	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
176299012378	RNA binding site [nucleotide binding]; other site
176299012379	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
176299012380	RNA binding site [nucleotide binding]; other site
176299012381	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
176299012382	RNA binding site [nucleotide binding]; other site
176299012383	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
176299012384	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
176299012385	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
176299012386	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
176299012387	catalytic site [active]
176299012388	putative active site [active]
176299012389	putative substrate binding site [chemical binding]; other site
176299012390	Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613
176299012391	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
176299012392	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
176299012393	putative NAD(P) binding site [chemical binding]; other site
176299012394	homodimer interface [polypeptide binding]; other site
176299012395	homotetramer interface [polypeptide binding]; other site
176299012396	active site
176299012397	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
176299012398	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299012399	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
176299012400	active site
176299012401	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
176299012402	antimicrobial peptide ABC transporter periplasmic binding protein SapA; Provisional; Region: PRK15109
176299012403	peptide binding site [polypeptide binding]; other site
176299012404	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299012405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012406	dimer interface [polypeptide binding]; other site
176299012407	conserved gate region; other site
176299012408	putative PBP binding loops; other site
176299012409	ABC-ATPase subunit interface; other site
176299012410	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299012411	dipeptide transporter; Provisional; Region: PRK10913
176299012412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012413	dimer interface [polypeptide binding]; other site
176299012414	conserved gate region; other site
176299012415	putative PBP binding loops; other site
176299012416	ABC-ATPase subunit interface; other site
176299012417	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299012418	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
176299012419	Walker A/P-loop; other site
176299012420	ATP binding site [chemical binding]; other site
176299012421	Q-loop/lid; other site
176299012422	ABC transporter signature motif; other site
176299012423	Walker B; other site
176299012424	D-loop; other site
176299012425	H-loop/switch region; other site
176299012426	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299012427	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
176299012428	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299012429	Walker A/P-loop; other site
176299012430	ATP binding site [chemical binding]; other site
176299012431	Q-loop/lid; other site
176299012432	ABC transporter signature motif; other site
176299012433	Walker B; other site
176299012434	D-loop; other site
176299012435	H-loop/switch region; other site
176299012436	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299012437	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299012438	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299012439	DNA-binding site [nucleotide binding]; DNA binding site
176299012440	FCD domain; Region: FCD; pfam07729
176299012441	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299012442	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
176299012443	active site pocket [active]
176299012444	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
176299012445	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
176299012446	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299012447	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299012448	LysR substrate binding domain; Region: LysR_substrate; pfam03466
176299012449	dimerization interface [polypeptide binding]; other site
176299012450	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
176299012451	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
176299012452	putative ligand binding site [chemical binding]; other site
176299012453	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
176299012454	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
176299012455	Walker A/P-loop; other site
176299012456	ATP binding site [chemical binding]; other site
176299012457	Q-loop/lid; other site
176299012458	ABC transporter signature motif; other site
176299012459	Walker B; other site
176299012460	D-loop; other site
176299012461	H-loop/switch region; other site
176299012462	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
176299012463	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
176299012464	Walker A/P-loop; other site
176299012465	ATP binding site [chemical binding]; other site
176299012466	Q-loop/lid; other site
176299012467	ABC transporter signature motif; other site
176299012468	Walker B; other site
176299012469	D-loop; other site
176299012470	H-loop/switch region; other site
176299012471	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299012472	TM-ABC transporter signature motif; other site
176299012473	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
176299012474	TM-ABC transporter signature motif; other site
176299012475	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
176299012476	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299012477	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299012478	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
176299012479	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
176299012480	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
176299012481	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
176299012482	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
176299012483	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
176299012484	acyl-activating enzyme (AAE) consensus motif; other site
176299012485	AMP binding site [chemical binding]; other site
176299012486	active site
176299012487	CoA binding site [chemical binding]; other site
176299012488	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
176299012489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299012490	NAD(P) binding site [chemical binding]; other site
176299012491	active site
176299012492	AraC-binding-like domain; Region: AraC_binding_2; pfam14525
176299012493	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
176299012494	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299012495	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
176299012496	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
176299012497	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
176299012498	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
176299012499	Trp docking motif [polypeptide binding]; other site
176299012500	putative active site [active]
176299012501	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
176299012502	dimerization interface [polypeptide binding]; other site
176299012503	metal binding site [ion binding]; metal-binding site
176299012504	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
176299012505	MgtC family; Region: MgtC; pfam02308
176299012506	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299012507	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
176299012508	TIGR02588 family protein; Region: TIGR02588
176299012509	putative integral membrane protein TIGR02587; Region: TIGR02587
176299012510	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
176299012511	trimer interface [polypeptide binding]; other site
176299012512	putative Zn binding site [ion binding]; other site
176299012513	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
176299012514	intracellular protease, PfpI family; Region: PfpI; TIGR01382
176299012515	proposed catalytic triad [active]
176299012516	conserved cys residue [active]
176299012517	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
176299012518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3930
176299012519	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
176299012520	glutathione synthetase; Provisional; Region: PRK12458
176299012521	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299012522	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
176299012523	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299012524	putative NAD(P) binding site [chemical binding]; other site
176299012525	active site
176299012526	putative substrate binding site [chemical binding]; other site
176299012527	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
176299012528	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
176299012529	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
176299012530	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
176299012531	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299012532	EamA-like transporter family; Region: EamA; pfam00892
176299012533	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299012534	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299012535	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
176299012536	dimerization interface [polypeptide binding]; other site
176299012537	substrate binding pocket [chemical binding]; other site
176299012538	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
176299012539	tetrameric interface [polypeptide binding]; other site
176299012540	NAD binding site [chemical binding]; other site
176299012541	catalytic residues [active]
176299012542	NMT1-like family; Region: NMT1_2; cl17432
176299012543	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
176299012544	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299012545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012546	dimer interface [polypeptide binding]; other site
176299012547	conserved gate region; other site
176299012548	putative PBP binding loops; other site
176299012549	ABC-ATPase subunit interface; other site
176299012550	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299012551	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299012552	Walker A/P-loop; other site
176299012553	ATP binding site [chemical binding]; other site
176299012554	Q-loop/lid; other site
176299012555	ABC transporter signature motif; other site
176299012556	Walker B; other site
176299012557	D-loop; other site
176299012558	H-loop/switch region; other site
176299012559	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
176299012560	DNA-binding domain of Proline dehydrogenase; Region: Pro_dh-DNA_bdg; pfam14850
176299012561	Proline dehydrogenase; Region: Pro_dh; pfam01619
176299012562	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
176299012563	Glutamate binding site [chemical binding]; other site
176299012564	NAD binding site [chemical binding]; other site
176299012565	catalytic residues [active]
176299012566	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
176299012567	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
176299012568	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299012569	putative DNA binding site [nucleotide binding]; other site
176299012570	putative Zn2+ binding site [ion binding]; other site
176299012571	AsnC family; Region: AsnC_trans_reg; pfam01037
176299012572	RNA polymerase sigma factor; Provisional; Region: PRK12547
176299012573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299012574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299012575	DNA binding residues [nucleotide binding]
176299012576	two-component response regulator; Provisional; Region: PRK09191
176299012577	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299012578	active site
176299012579	phosphorylation site [posttranslational modification]
176299012580	intermolecular recognition site; other site
176299012581	dimerization interface [polypeptide binding]; other site
176299012582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
176299012583	HWE histidine kinase; Region: HWE_HK; pfam07536
176299012584	HAMP domain; Region: HAMP; pfam00672
176299012585	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
176299012586	HWE histidine kinase; Region: HWE_HK; smart00911
176299012587	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
176299012588	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
176299012589	PRC-barrel domain; Region: PRC; pfam05239
176299012590	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
176299012591	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
176299012592	NAD binding site [chemical binding]; other site
176299012593	homodimer interface [polypeptide binding]; other site
176299012594	active site
176299012595	substrate binding site [chemical binding]; other site
176299012596	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
176299012597	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
176299012598	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
176299012599	dimer interface [polypeptide binding]; other site
176299012600	active site
176299012601	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299012602	catalytic residues [active]
176299012603	substrate binding site [chemical binding]; other site
176299012604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299012605	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
176299012606	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
176299012607	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
176299012608	ATP binding site [chemical binding]; other site
176299012609	Mg++ binding site [ion binding]; other site
176299012610	motif III; other site
176299012611	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
176299012612	nucleotide binding region [chemical binding]; other site
176299012613	ATP-binding site [chemical binding]; other site
176299012614	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
176299012615	RNA binding site [nucleotide binding]; other site
176299012616	aspartate kinase; Reviewed; Region: PRK06635
176299012617	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
176299012618	putative nucleotide binding site [chemical binding]; other site
176299012619	putative catalytic residues [active]
176299012620	putative Mg ion binding site [ion binding]; other site
176299012621	putative aspartate binding site [chemical binding]; other site
176299012622	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
176299012623	putative allosteric regulatory site; other site
176299012624	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
176299012625	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
176299012626	GAF domain; Region: GAF; pfam01590
176299012627	PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
176299012628	PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
176299012629	PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
176299012630	peptide chain release factor 1; Validated; Region: prfA; PRK00591
176299012631	This domain is found in peptide chain release factors; Region: PCRF; smart00937
176299012632	RF-1 domain; Region: RF-1; pfam00472
176299012633	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
176299012634	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299012635	S-adenosylmethionine binding site [chemical binding]; other site
176299012636	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
176299012637	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
176299012638	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
176299012639	Clp amino terminal domain; Region: Clp_N; pfam02861
176299012640	Clp amino terminal domain; Region: Clp_N; pfam02861
176299012641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299012642	Walker A motif; other site
176299012643	ATP binding site [chemical binding]; other site
176299012644	Walker B motif; other site
176299012645	arginine finger; other site
176299012646	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
176299012647	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299012648	Walker A motif; other site
176299012649	ATP binding site [chemical binding]; other site
176299012650	Walker B motif; other site
176299012651	arginine finger; other site
176299012652	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
176299012653	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
176299012654	Peptidase family M23; Region: Peptidase_M23; pfam01551
176299012655	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299012656	inhibitor site; inhibition site
176299012657	active site
176299012658	dimer interface [polypeptide binding]; other site
176299012659	catalytic residue [active]
176299012660	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
176299012661	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299012662	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299012663	DNA-binding site [nucleotide binding]; DNA binding site
176299012664	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299012665	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299012666	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
176299012667	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299012668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012669	dimer interface [polypeptide binding]; other site
176299012670	conserved gate region; other site
176299012671	putative PBP binding loops; other site
176299012672	ABC-ATPase subunit interface; other site
176299012673	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299012674	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
176299012675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012676	dimer interface [polypeptide binding]; other site
176299012677	conserved gate region; other site
176299012678	putative PBP binding loops; other site
176299012679	ABC-ATPase subunit interface; other site
176299012680	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299012681	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299012682	Walker A/P-loop; other site
176299012683	ATP binding site [chemical binding]; other site
176299012684	Q-loop/lid; other site
176299012685	ABC transporter signature motif; other site
176299012686	Walker B; other site
176299012687	D-loop; other site
176299012688	H-loop/switch region; other site
176299012689	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299012690	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299012691	Walker A/P-loop; other site
176299012692	ATP binding site [chemical binding]; other site
176299012693	Q-loop/lid; other site
176299012694	ABC transporter signature motif; other site
176299012695	Walker B; other site
176299012696	D-loop; other site
176299012697	H-loop/switch region; other site
176299012698	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299012699	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299012700	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
176299012701	active site pocket [active]
176299012702	aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021
176299012703	active site
176299012704	catalytic residues [active]
176299012705	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
176299012706	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299012707	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299012708	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299012709	WHG domain; Region: WHG; pfam13305
176299012710	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
176299012711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299012712	S-adenosylmethionine binding site [chemical binding]; other site
176299012713	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
176299012714	substrate binding site [chemical binding]; other site
176299012715	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299012716	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299012717	tetracycline repressor protein TetR; Provisional; Region: PRK13756
176299012718	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299012719	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
176299012720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299012721	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299012722	putative substrate translocation pore; other site
176299012723	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299012724	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299012725	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299012726	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
176299012727	nucleotide binding site [chemical binding]; other site
176299012728	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
176299012729	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299012730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012731	dimer interface [polypeptide binding]; other site
176299012732	conserved gate region; other site
176299012733	putative PBP binding loops; other site
176299012734	ABC-ATPase subunit interface; other site
176299012735	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299012736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012737	dimer interface [polypeptide binding]; other site
176299012738	conserved gate region; other site
176299012739	putative PBP binding loops; other site
176299012740	ABC-ATPase subunit interface; other site
176299012741	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299012742	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299012743	Walker A/P-loop; other site
176299012744	ATP binding site [chemical binding]; other site
176299012745	Q-loop/lid; other site
176299012746	ABC transporter signature motif; other site
176299012747	Walker B; other site
176299012748	D-loop; other site
176299012749	H-loop/switch region; other site
176299012750	TOBE domain; Region: TOBE_2; pfam08402
176299012751	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
176299012752	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
176299012753	putative active site [active]
176299012754	catalytic site [active]
176299012755	putative metal binding site [ion binding]; other site
176299012756	oligomer interface [polypeptide binding]; other site
176299012757	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
176299012758	DNA-binding site [nucleotide binding]; DNA binding site
176299012759	RNA-binding motif; other site
176299012760	Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017
176299012761	nucleotide binding site [chemical binding]; other site
176299012762	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
176299012763	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
176299012764	dimer interface [polypeptide binding]; other site
176299012765	active site
176299012766	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299012767	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299012768	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299012769	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299012770	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299012771	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299012772	MMPL family; Region: MMPL; cl14618
176299012773	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
176299012774	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299012775	NAD(P) binding site [chemical binding]; other site
176299012776	active site
176299012777	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
176299012778	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
176299012779	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
176299012780	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
176299012781	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
176299012782	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
176299012783	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
176299012784	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299012785	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
176299012786	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
176299012787	conserved cys residue [active]
176299012788	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299012789	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299012790	non-specific DNA binding site [nucleotide binding]; other site
176299012791	salt bridge; other site
176299012792	sequence-specific DNA binding site [nucleotide binding]; other site
176299012793	Cupin domain; Region: Cupin_2; pfam07883
176299012794	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
176299012795	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
176299012796	putative active site [active]
176299012797	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
176299012798	domain_subunit interface; other site
176299012799	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
176299012800	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
176299012801	active site
176299012802	FMN binding site [chemical binding]; other site
176299012803	substrate binding site [chemical binding]; other site
176299012804	3Fe-4S cluster binding site [ion binding]; other site
176299012805	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
176299012806	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
176299012807	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
176299012808	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
176299012809	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
176299012810	putative active site [active]
176299012811	putative substrate binding site [chemical binding]; other site
176299012812	putative cosubstrate binding site; other site
176299012813	catalytic site [active]
176299012814	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299012815	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299012816	DNA-binding site [nucleotide binding]; DNA binding site
176299012817	FCD domain; Region: FCD; pfam07729
176299012818	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299012819	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299012820	substrate binding pocket [chemical binding]; other site
176299012821	membrane-bound complex binding site; other site
176299012822	hinge residues; other site
176299012823	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299012824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012825	dimer interface [polypeptide binding]; other site
176299012826	conserved gate region; other site
176299012827	putative PBP binding loops; other site
176299012828	ABC-ATPase subunit interface; other site
176299012829	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299012830	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299012831	Walker A/P-loop; other site
176299012832	ATP binding site [chemical binding]; other site
176299012833	Q-loop/lid; other site
176299012834	ABC transporter signature motif; other site
176299012835	Walker B; other site
176299012836	D-loop; other site
176299012837	H-loop/switch region; other site
176299012838	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
176299012839	putative active site [active]
176299012840	metal binding site [ion binding]; metal-binding site
176299012841	Amino acid synthesis; Region: AA_synth; pfam06684
176299012842	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299012843	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299012844	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
176299012845	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
176299012846	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
176299012847	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
176299012848	NAD(P) binding site [chemical binding]; other site
176299012849	catalytic residues [active]
176299012850	NIPSNAP; Region: NIPSNAP; pfam07978
176299012851	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
176299012852	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299012853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012854	dimer interface [polypeptide binding]; other site
176299012855	conserved gate region; other site
176299012856	putative PBP binding loops; other site
176299012857	ABC-ATPase subunit interface; other site
176299012858	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299012859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012860	dimer interface [polypeptide binding]; other site
176299012861	conserved gate region; other site
176299012862	putative PBP binding loops; other site
176299012863	ABC-ATPase subunit interface; other site
176299012864	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299012865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299012866	Walker A/P-loop; other site
176299012867	ATP binding site [chemical binding]; other site
176299012868	Q-loop/lid; other site
176299012869	ABC transporter signature motif; other site
176299012870	Walker B; other site
176299012871	D-loop; other site
176299012872	H-loop/switch region; other site
176299012873	TOBE domain; Region: TOBE_2; pfam08402
176299012874	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
176299012875	tetramerization interface [polypeptide binding]; other site
176299012876	NAD(P) binding site [chemical binding]; other site
176299012877	catalytic residues [active]
176299012878	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299012879	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299012880	Walker A/P-loop; other site
176299012881	ATP binding site [chemical binding]; other site
176299012882	Q-loop/lid; other site
176299012883	ABC transporter signature motif; other site
176299012884	Walker B; other site
176299012885	D-loop; other site
176299012886	H-loop/switch region; other site
176299012887	TOBE domain; Region: TOBE_2; pfam08402
176299012888	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299012889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012890	dimer interface [polypeptide binding]; other site
176299012891	conserved gate region; other site
176299012892	putative PBP binding loops; other site
176299012893	ABC-ATPase subunit interface; other site
176299012894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012895	dimer interface [polypeptide binding]; other site
176299012896	conserved gate region; other site
176299012897	putative PBP binding loops; other site
176299012898	ABC-ATPase subunit interface; other site
176299012899	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299012900	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299012901	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
176299012902	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299012903	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299012904	DNA binding site [nucleotide binding]
176299012905	domain linker motif; other site
176299012906	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
176299012907	ligand binding site [chemical binding]; other site
176299012908	dimerization interface [polypeptide binding]; other site
176299012909	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299012910	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299012911	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
176299012912	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299012913	Walker A/P-loop; other site
176299012914	ATP binding site [chemical binding]; other site
176299012915	Q-loop/lid; other site
176299012916	ABC transporter signature motif; other site
176299012917	Walker B; other site
176299012918	D-loop; other site
176299012919	H-loop/switch region; other site
176299012920	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299012921	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299012922	Walker A/P-loop; other site
176299012923	ATP binding site [chemical binding]; other site
176299012924	Q-loop/lid; other site
176299012925	ABC transporter signature motif; other site
176299012926	Walker B; other site
176299012927	D-loop; other site
176299012928	H-loop/switch region; other site
176299012929	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299012930	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012931	dimer interface [polypeptide binding]; other site
176299012932	conserved gate region; other site
176299012933	putative PBP binding loops; other site
176299012934	ABC-ATPase subunit interface; other site
176299012935	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
176299012936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012937	dimer interface [polypeptide binding]; other site
176299012938	conserved gate region; other site
176299012939	putative PBP binding loops; other site
176299012940	ABC-ATPase subunit interface; other site
176299012941	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
176299012942	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
176299012943	peptide binding site [polypeptide binding]; other site
176299012944	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299012945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299012946	dimer interface [polypeptide binding]; other site
176299012947	conserved gate region; other site
176299012948	putative PBP binding loops; other site
176299012949	ABC-ATPase subunit interface; other site
176299012950	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299012951	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299012952	Walker A/P-loop; other site
176299012953	ATP binding site [chemical binding]; other site
176299012954	Q-loop/lid; other site
176299012955	ABC transporter signature motif; other site
176299012956	Walker B; other site
176299012957	D-loop; other site
176299012958	H-loop/switch region; other site
176299012959	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
176299012960	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299012961	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299012962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
176299012963	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299012964	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299012965	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
176299012966	putative dimerization interface [polypeptide binding]; other site
176299012967	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
176299012968	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299012969	DNA-binding site [nucleotide binding]; DNA binding site
176299012970	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
176299012971	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299012972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299012973	homodimer interface [polypeptide binding]; other site
176299012974	catalytic residue [active]
176299012975	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
176299012976	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299012977	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
176299012978	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
176299012979	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
176299012980	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
176299012981	dimer interface [polypeptide binding]; other site
176299012982	ADP-ribose binding site [chemical binding]; other site
176299012983	active site
176299012984	nudix motif; other site
176299012985	metal binding site [ion binding]; metal-binding site
176299012986	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299012987	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299012988	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
176299012989	putative effector binding pocket; other site
176299012990	putative dimerization interface [polypeptide binding]; other site
176299012991	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
176299012992	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
176299012993	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
176299012994	carboxyltransferase (CT) interaction site; other site
176299012995	biotinylation site [posttranslational modification]; other site
176299012996	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111
176299012997	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
176299012998	ATP-grasp domain; Region: ATP-grasp_4; cl17255
176299012999	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
176299013000	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
176299013001	lipoyl-biotinyl attachment site [posttranslational modification]; other site
176299013002	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
176299013003	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
176299013004	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
176299013005	putative active site [active]
176299013006	aspartate aminotransferase; Provisional; Region: PRK05764
176299013007	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299013008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299013009	homodimer interface [polypeptide binding]; other site
176299013010	catalytic residue [active]
176299013011	nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233
176299013012	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299013013	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
176299013014	putative dimerization interface [polypeptide binding]; other site
176299013015	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
176299013016	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299013017	NAD(P) binding site [chemical binding]; other site
176299013018	active site
176299013019	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299013020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013021	dimer interface [polypeptide binding]; other site
176299013022	conserved gate region; other site
176299013023	putative PBP binding loops; other site
176299013024	ABC-ATPase subunit interface; other site
176299013025	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299013026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013027	dimer interface [polypeptide binding]; other site
176299013028	conserved gate region; other site
176299013029	putative PBP binding loops; other site
176299013030	ABC-ATPase subunit interface; other site
176299013031	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299013032	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299013033	Walker A/P-loop; other site
176299013034	ATP binding site [chemical binding]; other site
176299013035	Q-loop/lid; other site
176299013036	ABC transporter signature motif; other site
176299013037	Walker B; other site
176299013038	D-loop; other site
176299013039	H-loop/switch region; other site
176299013040	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299013041	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299013042	substrate binding pocket [chemical binding]; other site
176299013043	membrane-bound complex binding site; other site
176299013044	hinge residues; other site
176299013045	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
176299013046	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
176299013047	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
176299013048	potential catalytic triad [active]
176299013049	conserved cys residue [active]
176299013050	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
176299013051	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
176299013052	potential catalytic triad [active]
176299013053	conserved cys residue [active]
176299013054	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299013055	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299013056	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299013057	putative effector binding pocket; other site
176299013058	dimerization interface [polypeptide binding]; other site
176299013059	Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281
176299013060	putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366
176299013061	substrate binding site [chemical binding]; other site
176299013062	catalytic Zn binding site [ion binding]; other site
176299013063	structural Zn binding site [ion binding]; other site
176299013064	NAD binding site [chemical binding]; other site
176299013065	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299013066	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299013067	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480
176299013068	putative effector binding pocket; other site
176299013069	putative dimerization interface [polypeptide binding]; other site
176299013070	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
176299013071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299013072	putative substrate translocation pore; other site
176299013073	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
176299013074	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299013075	active site
176299013076	catalytic tetrad [active]
176299013077	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
176299013078	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
176299013079	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
176299013080	shikimate binding site; other site
176299013081	NAD(P) binding site [chemical binding]; other site
176299013082	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
176299013083	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299013084	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299013085	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
176299013086	Cupin domain; Region: Cupin_2; cl17218
176299013087	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299013088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299013089	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299013090	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
176299013091	Mechanosensitive ion channel; Region: MS_channel; pfam00924
176299013092	Predicted transcriptional regulator [Transcription]; Region: COG1959
176299013093	Rrf2 family protein; Region: rrf2_super; TIGR00738
176299013094	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
176299013095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299013096	active site
176299013097	phosphorylation site [posttranslational modification]
176299013098	intermolecular recognition site; other site
176299013099	dimerization interface [polypeptide binding]; other site
176299013100	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299013101	DNA binding residues [nucleotide binding]
176299013102	dimerization interface [polypeptide binding]; other site
176299013103	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
176299013104	NADH(P)-binding; Region: NAD_binding_10; pfam13460
176299013105	NAD(P) binding site [chemical binding]; other site
176299013106	active site
176299013107	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
176299013108	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_6; cd04619
176299013109	FOG: CBS domain [General function prediction only]; Region: COG0517
176299013110	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
176299013111	Mechanosensitive ion channel; Region: MS_channel; pfam00924
176299013112	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299013113	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299013114	ligand binding site [chemical binding]; other site
176299013115	flexible hinge region; other site
176299013116	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299013117	PAS fold; Region: PAS_3; pfam08447
176299013118	putative active site [active]
176299013119	heme pocket [chemical binding]; other site
176299013120	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299013121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299013122	heme pocket [chemical binding]; other site
176299013123	putative active site [active]
176299013124	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299013125	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299013126	putative active site [active]
176299013127	heme pocket [chemical binding]; other site
176299013128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299013129	putative active site [active]
176299013130	heme pocket [chemical binding]; other site
176299013131	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299013132	dimer interface [polypeptide binding]; other site
176299013133	phosphorylation site [posttranslational modification]
176299013134	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299013135	ATP binding site [chemical binding]; other site
176299013136	Mg2+ binding site [ion binding]; other site
176299013137	G-X-G motif; other site
176299013138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299013139	active site
176299013140	phosphorylation site [posttranslational modification]
176299013141	intermolecular recognition site; other site
176299013142	dimerization interface [polypeptide binding]; other site
176299013143	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
176299013144	Predicted integral membrane protein [Function unknown]; Region: COG5473
176299013145	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
176299013146	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
176299013147	conserved cys residue [active]
176299013148	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299013149	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
176299013150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299013151	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
176299013152	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
176299013153	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
176299013154	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299013155	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
176299013156	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
176299013157	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
176299013158	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
176299013159	dimer interface [polypeptide binding]; other site
176299013160	active site
176299013161	glycine-pyridoxal phosphate binding site [chemical binding]; other site
176299013162	folate binding site [chemical binding]; other site
176299013163	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
176299013164	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
176299013165	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
176299013166	putative active site [active]
176299013167	putative substrate binding site [chemical binding]; other site
176299013168	putative cosubstrate binding site; other site
176299013169	catalytic site [active]
176299013170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299013171	putative substrate translocation pore; other site
176299013172	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299013173	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299013174	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299013175	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
176299013176	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
176299013177	inhibitor binding site; inhibition site
176299013178	catalytic Zn binding site [ion binding]; other site
176299013179	structural Zn binding site [ion binding]; other site
176299013180	NADP binding site [chemical binding]; other site
176299013181	tetramer interface [polypeptide binding]; other site
176299013182	Cupin domain; Region: Cupin_2; cl17218
176299013183	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299013184	Helix-turn-helix domain; Region: HTH_18; pfam12833
176299013185	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299013186	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
176299013187	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299013188	putative ligand binding site [chemical binding]; other site
176299013189	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299013190	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299013191	Walker A/P-loop; other site
176299013192	ATP binding site [chemical binding]; other site
176299013193	Q-loop/lid; other site
176299013194	ABC transporter signature motif; other site
176299013195	Walker B; other site
176299013196	D-loop; other site
176299013197	H-loop/switch region; other site
176299013198	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299013199	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299013200	TM-ABC transporter signature motif; other site
176299013201	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
176299013202	classical (c) SDRs; Region: SDR_c; cd05233
176299013203	NAD(P) binding site [chemical binding]; other site
176299013204	active site
176299013205	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
176299013206	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
176299013207	N- and C-terminal domain interface [polypeptide binding]; other site
176299013208	active site
176299013209	MgATP binding site [chemical binding]; other site
176299013210	catalytic site [active]
176299013211	metal binding site [ion binding]; metal-binding site
176299013212	carbohydrate binding site [chemical binding]; other site
176299013213	putative homodimer interface [polypeptide binding]; other site
176299013214	short chain dehydrogenase; Provisional; Region: PRK07060
176299013215	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299013216	NAD(P) binding site [chemical binding]; other site
176299013217	active site
176299013218	proline/glycine betaine transporter; Provisional; Region: PRK10642
176299013219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299013220	putative substrate translocation pore; other site
176299013221	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
176299013222	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
176299013223	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
176299013224	Catalytic domain of Protein Kinases; Region: PKc; cd00180
176299013225	Protein kinase domain; Region: Pkinase; pfam00069
176299013226	active site
176299013227	ATP binding site [chemical binding]; other site
176299013228	substrate binding site [chemical binding]; other site
176299013229	activation loop (A-loop); other site
176299013230	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SciT; COG3913
176299013231	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
176299013232	active site
176299013233	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
176299013234	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
176299013235	G1 box; other site
176299013236	GTP/Mg2+ binding site [chemical binding]; other site
176299013237	G2 box; other site
176299013238	G3 box; other site
176299013239	Switch II region; other site
176299013240	ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331
176299013241	G4 box; other site
176299013242	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
176299013243	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
176299013244	Type VI protein secretion system component VasF [Intracellular    trafficking, secretion, and vesicular transport]; Region: COG3455
176299013245	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
176299013246	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
176299013247	ligand binding site [chemical binding]; other site
176299013248	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
176299013249	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
176299013250	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
176299013251	phosphopeptide binding site; other site
176299013252	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3520
176299013253	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
176299013254	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3518
176299013255	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
176299013256	ImpE protein; Region: ImpE; pfam07024
176299013257	Protein of unknown function (DUF877); Region: DUF877; cl05484
176299013258	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
176299013259	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3516
176299013260	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3515
176299013261	ImpA-related N-terminal; Region: ImpA-rel_N; cl19907
176299013262	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
176299013263	Clp amino terminal domain; Region: Clp_N; pfam02861
176299013264	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299013265	Walker A motif; other site
176299013266	ATP binding site [chemical binding]; other site
176299013267	Walker B motif; other site
176299013268	arginine finger; other site
176299013269	Protein of unknown function (DUF2890); Region: DUF2890; pfam11081
176299013270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299013271	Walker A motif; other site
176299013272	ATP binding site [chemical binding]; other site
176299013273	Walker B motif; other site
176299013274	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
176299013275	Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion,    and vesicular transport]; Region: Hcp; COG3157
176299013276	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
176299013277	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
176299013278	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
176299013279	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
176299013280	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
176299013281	Putative toxin 43; Region: Toxin_43; pfam15604
176299013282	GAD-like domain; Region: GAD-like; pfam08887
176299013283	Uncharacterized conserved protein [Function unknown]; Region: COG5620
176299013284	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
176299013285	Uncharacterized conserved protein [Function unknown]; Region: COG4104
176299013286	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
176299013287	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299013288	metal binding site [ion binding]; metal-binding site
176299013289	active site
176299013290	I-site; other site
176299013291	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299013292	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
176299013293	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
176299013294	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
176299013295	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
176299013296	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
176299013297	Transporter associated domain; Region: CorC_HlyC; smart01091
176299013298	Protein of unknown function (DUF1402); Region: DUF1402; pfam07182
176299013299	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
176299013300	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299013301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299013302	Walker A/P-loop; other site
176299013303	ATP binding site [chemical binding]; other site
176299013304	Q-loop/lid; other site
176299013305	ABC transporter signature motif; other site
176299013306	Walker B; other site
176299013307	D-loop; other site
176299013308	H-loop/switch region; other site
176299013309	TOBE domain; Region: TOBE_2; pfam08402
176299013310	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299013311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013312	dimer interface [polypeptide binding]; other site
176299013313	conserved gate region; other site
176299013314	ABC-ATPase subunit interface; other site
176299013315	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299013316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013317	dimer interface [polypeptide binding]; other site
176299013318	conserved gate region; other site
176299013319	putative PBP binding loops; other site
176299013320	ABC-ATPase subunit interface; other site
176299013321	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299013322	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299013323	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299013324	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299013325	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299013326	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299013327	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299013328	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299013329	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299013330	DNA binding site [nucleotide binding]
176299013331	domain linker motif; other site
176299013332	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
176299013333	ligand binding site [chemical binding]; other site
176299013334	short chain dehydrogenase; Provisional; Region: PRK12744
176299013335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299013336	NAD(P) binding site [chemical binding]; other site
176299013337	active site
176299013338	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299013339	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299013340	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
176299013341	putative effector binding pocket; other site
176299013342	putative dimerization interface [polypeptide binding]; other site
176299013343	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
176299013344	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299013345	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
176299013346	putative ligand binding site [chemical binding]; other site
176299013347	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299013348	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299013349	Walker A/P-loop; other site
176299013350	ATP binding site [chemical binding]; other site
176299013351	Q-loop/lid; other site
176299013352	ABC transporter signature motif; other site
176299013353	Walker B; other site
176299013354	D-loop; other site
176299013355	H-loop/switch region; other site
176299013356	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299013357	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299013358	TM-ABC transporter signature motif; other site
176299013359	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299013360	TM-ABC transporter signature motif; other site
176299013361	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299013362	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299013363	DNA binding site [nucleotide binding]
176299013364	domain linker motif; other site
176299013365	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
176299013366	dimerization interface [polypeptide binding]; other site
176299013367	ligand binding site [chemical binding]; other site
176299013368	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299013369	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299013370	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
176299013371	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299013372	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299013373	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299013374	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299013375	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299013376	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
176299013377	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299013378	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299013379	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
176299013380	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
176299013381	Cytochrome c2 [Energy production and conversion]; Region: COG3474
176299013382	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299013383	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299013384	ligand binding site [chemical binding]; other site
176299013385	flexible hinge region; other site
176299013386	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
176299013387	putative switch regulator; other site
176299013388	non-specific DNA interactions [nucleotide binding]; other site
176299013389	DNA binding site [nucleotide binding]
176299013390	sequence specific DNA binding site [nucleotide binding]; other site
176299013391	putative cAMP binding site [chemical binding]; other site
176299013392	Uncharacterized conserved protein [Function unknown]; Region: COG1262
176299013393	Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582
176299013394	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
176299013395	Cupredoxin superfamily; Region: Cupredoxin; cl19115
176299013396	Cupredoxin superfamily; Region: Cupredoxin; cl19115
176299013397	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
176299013398	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
176299013399	Uncharacterized conserved protein [Function unknown]; Region: COG4309
176299013400	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
176299013401	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
176299013402	metal ion-dependent adhesion site (MIDAS); other site
176299013403	MoxR-like ATPases [General function prediction only]; Region: COG0714
176299013404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299013405	Walker A motif; other site
176299013406	ATP binding site [chemical binding]; other site
176299013407	Walker B motif; other site
176299013408	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
176299013409	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
176299013410	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
176299013411	Low-spin heme binding site [chemical binding]; other site
176299013412	D-pathway; other site
176299013413	K-pathway; other site
176299013414	Binuclear center (active site) [active]
176299013415	Putative proton exit pathway; other site
176299013416	Putative water exit pathway; other site
176299013417	Cytochrome c; Region: Cytochrom_C; pfam00034
176299013418	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
176299013419	Subunit I/III interface [polypeptide binding]; other site
176299013420	Predicted membrane protein [Function unknown]; Region: COG4094
176299013421	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
176299013422	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
176299013423	Uncharacterized conserved protein [Function unknown]; Region: COG3189
176299013424	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
176299013425	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
176299013426	putative protease; Provisional; Region: PRK15447
176299013427	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
176299013428	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
176299013429	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
176299013430	N-terminal plug; other site
176299013431	ligand-binding site [chemical binding]; other site
176299013432	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299013433	NMT1-like family; Region: NMT1_2; cl17432
176299013434	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299013435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013436	dimer interface [polypeptide binding]; other site
176299013437	conserved gate region; other site
176299013438	putative PBP binding loops; other site
176299013439	ABC-ATPase subunit interface; other site
176299013440	ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
176299013441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299013442	Walker A/P-loop; other site
176299013443	ATP binding site [chemical binding]; other site
176299013444	Q-loop/lid; other site
176299013445	ABC transporter signature motif; other site
176299013446	Walker B; other site
176299013447	D-loop; other site
176299013448	H-loop/switch region; other site
176299013449	Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213
176299013450	Periplasmic nitrate reductase system, NapE component [Energy production and conversion]; Region: NapE; COG4459
176299013451	ferredoxin-type protein; Provisional; Region: PRK10194
176299013452	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
176299013453	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
176299013454	Uncharacterized protein involved in formation of periplasmic nitrate reductase [Inorganic ion transport and metabolism]; Region: NapD; COG3062
176299013455	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
176299013456	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
176299013457	[4Fe-4S] binding site [ion binding]; other site
176299013458	molybdopterin cofactor binding site; other site
176299013459	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
176299013460	molybdopterin cofactor binding site; other site
176299013461	Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043
176299013462	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
176299013463	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
176299013464	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299013465	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
176299013466	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
176299013467	dimerization interface [polypeptide binding]; other site
176299013468	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
176299013469	active site
176299013470	metal binding site [ion binding]; metal-binding site
176299013471	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
176299013472	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
176299013473	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
176299013474	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
176299013475	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
176299013476	Ca2+ binding site [ion binding]; other site
176299013477	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
176299013478	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299013479	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299013480	Walker A/P-loop; other site
176299013481	ATP binding site [chemical binding]; other site
176299013482	Q-loop/lid; other site
176299013483	ABC transporter signature motif; other site
176299013484	Walker B; other site
176299013485	D-loop; other site
176299013486	H-loop/switch region; other site
176299013487	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
176299013488	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
176299013489	lipoyl-biotinyl attachment site [posttranslational modification]; other site
176299013490	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299013491	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
176299013492	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
176299013493	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
176299013494	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
176299013495	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
176299013496	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299013497	FAD binding site [chemical binding]; other site
176299013498	substrate binding pocket [chemical binding]; other site
176299013499	catalytic base [active]
176299013500	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299013501	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299013502	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
176299013503	dimerization interface [polypeptide binding]; other site
176299013504	substrate binding pocket [chemical binding]; other site
176299013505	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299013506	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299013507	DNA binding site [nucleotide binding]
176299013508	domain linker motif; other site
176299013509	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
176299013510	dimerization interface [polypeptide binding]; other site
176299013511	ligand binding site [chemical binding]; other site
176299013512	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
176299013513	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
176299013514	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299013515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013516	dimer interface [polypeptide binding]; other site
176299013517	conserved gate region; other site
176299013518	putative PBP binding loops; other site
176299013519	ABC-ATPase subunit interface; other site
176299013520	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299013521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013522	dimer interface [polypeptide binding]; other site
176299013523	conserved gate region; other site
176299013524	putative PBP binding loops; other site
176299013525	ABC-ATPase subunit interface; other site
176299013526	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299013527	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299013528	Walker A/P-loop; other site
176299013529	ATP binding site [chemical binding]; other site
176299013530	Q-loop/lid; other site
176299013531	ABC transporter signature motif; other site
176299013532	Walker B; other site
176299013533	D-loop; other site
176299013534	H-loop/switch region; other site
176299013535	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
176299013536	active site
176299013537	tetramer interface [polypeptide binding]; other site
176299013538	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
176299013539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
176299013540	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
176299013541	active site
176299013542	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
176299013543	replicative DNA helicase; Provisional; Region: PRK05973
176299013544	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
176299013545	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
176299013546	metal binding site [ion binding]; metal-binding site
176299013547	putative dimer interface [polypeptide binding]; other site
176299013548	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
176299013549	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
176299013550	active site
176299013551	dimer interface [polypeptide binding]; other site
176299013552	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299013553	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
176299013554	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299013555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013556	dimer interface [polypeptide binding]; other site
176299013557	conserved gate region; other site
176299013558	putative PBP binding loops; other site
176299013559	ABC-ATPase subunit interface; other site
176299013560	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299013561	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299013562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013563	dimer interface [polypeptide binding]; other site
176299013564	conserved gate region; other site
176299013565	putative PBP binding loops; other site
176299013566	ABC-ATPase subunit interface; other site
176299013567	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299013568	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299013569	Walker A/P-loop; other site
176299013570	ATP binding site [chemical binding]; other site
176299013571	Q-loop/lid; other site
176299013572	ABC transporter signature motif; other site
176299013573	Walker B; other site
176299013574	D-loop; other site
176299013575	H-loop/switch region; other site
176299013576	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299013577	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299013578	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299013579	Walker A/P-loop; other site
176299013580	ATP binding site [chemical binding]; other site
176299013581	Q-loop/lid; other site
176299013582	ABC transporter signature motif; other site
176299013583	Walker B; other site
176299013584	D-loop; other site
176299013585	H-loop/switch region; other site
176299013586	Transposase domain (DUF772); Region: DUF772; pfam05598
176299013587	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
176299013588	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
176299013589	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
176299013590	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299013591	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299013592	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426
176299013593	putative dimerization interface [polypeptide binding]; other site
176299013594	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299013595	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
176299013596	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299013597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013598	dimer interface [polypeptide binding]; other site
176299013599	conserved gate region; other site
176299013600	putative PBP binding loops; other site
176299013601	ABC-ATPase subunit interface; other site
176299013602	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
176299013603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013604	dimer interface [polypeptide binding]; other site
176299013605	conserved gate region; other site
176299013606	putative PBP binding loops; other site
176299013607	ABC-ATPase subunit interface; other site
176299013608	amidase; Provisional; Region: PRK07042
176299013609	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
176299013610	intracellular protease, PfpI family; Region: PfpI; TIGR01382
176299013611	conserved cys residue [active]
176299013612	Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321
176299013613	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
176299013614	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
176299013615	metal binding site [ion binding]; metal-binding site
176299013616	putative dimer interface [polypeptide binding]; other site
176299013617	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299013618	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299013619	Walker A/P-loop; other site
176299013620	ATP binding site [chemical binding]; other site
176299013621	Q-loop/lid; other site
176299013622	ABC transporter signature motif; other site
176299013623	Walker B; other site
176299013624	D-loop; other site
176299013625	H-loop/switch region; other site
176299013626	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299013627	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299013628	Walker A/P-loop; other site
176299013629	ATP binding site [chemical binding]; other site
176299013630	Q-loop/lid; other site
176299013631	ABC transporter signature motif; other site
176299013632	Walker B; other site
176299013633	D-loop; other site
176299013634	H-loop/switch region; other site
176299013635	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299013636	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
176299013637	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
176299013638	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299013639	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299013640	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299013641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013642	dimer interface [polypeptide binding]; other site
176299013643	conserved gate region; other site
176299013644	putative PBP binding loops; other site
176299013645	ABC-ATPase subunit interface; other site
176299013646	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299013647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013648	dimer interface [polypeptide binding]; other site
176299013649	conserved gate region; other site
176299013650	putative PBP binding loops; other site
176299013651	ABC-ATPase subunit interface; other site
176299013652	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299013653	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299013654	Walker A/P-loop; other site
176299013655	ATP binding site [chemical binding]; other site
176299013656	Q-loop/lid; other site
176299013657	ABC transporter signature motif; other site
176299013658	Walker B; other site
176299013659	D-loop; other site
176299013660	H-loop/switch region; other site
176299013661	TOBE domain; Region: TOBE_2; pfam08402
176299013662	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
176299013663	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
176299013664	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
176299013665	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
176299013666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
176299013667	active site
176299013668	motif I; other site
176299013669	motif II; other site
176299013670	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
176299013671	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
176299013672	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
176299013673	N- and C-terminal domain interface [polypeptide binding]; other site
176299013674	active site
176299013675	MgATP binding site [chemical binding]; other site
176299013676	catalytic site [active]
176299013677	metal binding site [ion binding]; metal-binding site
176299013678	carbohydrate binding site [chemical binding]; other site
176299013679	putative homodimer interface [polypeptide binding]; other site
176299013680	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
176299013681	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
176299013682	CysZ-like protein; Reviewed; Region: PRK12768
176299013683	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
176299013684	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
176299013685	minor groove reading motif; other site
176299013686	helix-hairpin-helix signature motif; other site
176299013687	substrate binding pocket [chemical binding]; other site
176299013688	active site
176299013689	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
176299013690	Integral membrane protein [Function unknown]; Region: COG5488
176299013691	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299013692	Helix-turn-helix domain; Region: HTH_18; pfam12833
176299013693	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
176299013694	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
176299013695	DNA binding site [nucleotide binding]
176299013696	active site
176299013697	Predicted transcriptional regulator [Transcription]; Region: COG3905
176299013698	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
176299013699	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
176299013700	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
176299013701	DNA binding residues [nucleotide binding]
176299013702	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
176299013703	transaldolase-like protein; Provisional; Region: PTZ00411
176299013704	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
176299013705	active site
176299013706	dimer interface [polypeptide binding]; other site
176299013707	catalytic residue [active]
176299013708	Transcriptional regulator [Transcription]; Region: IclR; COG1414
176299013709	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299013710	putative DNA binding site [nucleotide binding]; other site
176299013711	putative Zn2+ binding site [ion binding]; other site
176299013712	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299013713	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299013714	human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368
176299013715	NAD binding site [chemical binding]; other site
176299013716	homotetramer interface [polypeptide binding]; other site
176299013717	homodimer interface [polypeptide binding]; other site
176299013718	active site
176299013719	hypothetical protein; Provisional; Region: PRK13682
176299013720	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299013721	ABC-ATPase subunit  interface; other site
176299013722	dimer interface [polypeptide binding]; other site
176299013723	putative PBP binding regions; other site
176299013724	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299013725	ABC-ATPase subunit  interface; other site
176299013726	dimer interface [polypeptide binding]; other site
176299013727	putative PBP binding regions; other site
176299013728	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
176299013729	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
176299013730	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
176299013731	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
176299013732	metal binding site [ion binding]; metal-binding site
176299013733	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
176299013734	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
176299013735	dimer interface [polypeptide binding]; other site
176299013736	putative anticodon binding site; other site
176299013737	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
176299013738	motif 1; other site
176299013739	active site
176299013740	motif 2; other site
176299013741	motif 3; other site
176299013742	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
176299013743	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
176299013744	active site
176299013745	HIGH motif; other site
176299013746	KMSKS motif; other site
176299013747	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
176299013748	transmembrane helices; other site
176299013749	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
176299013750	TrkA-C domain; Region: TrkA_C; pfam02080
176299013751	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
176299013752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299013753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299013754	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
176299013755	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
176299013756	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299013757	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299013758	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
176299013759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299013760	putative substrate translocation pore; other site
176299013761	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
176299013762	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
176299013763	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299013764	DNA binding site [nucleotide binding]
176299013765	domain linker motif; other site
176299013766	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
176299013767	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299013768	putative ligand binding site [chemical binding]; other site
176299013769	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
176299013770	N- and C-terminal domain interface [polypeptide binding]; other site
176299013771	D-xylulose kinase; Region: XylB; TIGR01312
176299013772	active site
176299013773	MgATP binding site [chemical binding]; other site
176299013774	catalytic site [active]
176299013775	metal binding site [ion binding]; metal-binding site
176299013776	xylulose binding site [chemical binding]; other site
176299013777	homodimer interface [polypeptide binding]; other site
176299013778	Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; COG2115
176299013779	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
176299013780	beta-galactosidase; Region: BGL; TIGR03356
176299013781	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
176299013782	dimer interface [polypeptide binding]; other site
176299013783	FMN binding site [chemical binding]; other site
176299013784	Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168
176299013785	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
176299013786	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
176299013787	Walker A/P-loop; other site
176299013788	ATP binding site [chemical binding]; other site
176299013789	Q-loop/lid; other site
176299013790	ABC transporter signature motif; other site
176299013791	Walker B; other site
176299013792	D-loop; other site
176299013793	H-loop/switch region; other site
176299013794	NIL domain; Region: NIL; pfam09383
176299013795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013796	dimer interface [polypeptide binding]; other site
176299013797	conserved gate region; other site
176299013798	ABC-ATPase subunit interface; other site
176299013799	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
176299013800	CHASE4 domain; Region: CHASE4; pfam05228
176299013801	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299013802	metal binding site [ion binding]; metal-binding site
176299013803	active site
176299013804	I-site; other site
176299013805	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299013806	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
176299013807	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
176299013808	active site residue [active]
176299013809	CHAD domain; Region: CHAD; pfam05235
176299013810	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
176299013811	putative active site [active]
176299013812	putative metal binding residues [ion binding]; other site
176299013813	signature motif; other site
176299013814	putative dimer interface [polypeptide binding]; other site
176299013815	putative phosphate binding site [ion binding]; other site
176299013816	Entner-Doudoroff aldolase; Region: eda; TIGR01182
176299013817	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
176299013818	active site
176299013819	intersubunit interface [polypeptide binding]; other site
176299013820	catalytic residue [active]
176299013821	Protein of unknown function (DUF533); Region: DUF533; pfam04391
176299013822	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
176299013823	putative metal binding site [ion binding]; other site
176299013824	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
176299013825	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299013826	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
176299013827	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683
176299013828	sugar efflux transporter; Region: 2A0120; TIGR00899
176299013829	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299013830	putative substrate translocation pore; other site
176299013831	FOG: WD40 repeat [General function prediction only]; Region: COG2319
176299013832	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
176299013833	structural tetrad; other site
176299013834	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
176299013835	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
176299013836	P-loop, Walker A motif; other site
176299013837	Base recognition motif; other site
176299013838	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
176299013839	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
176299013840	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299013841	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299013842	putative DNA binding site [nucleotide binding]; other site
176299013843	putative Zn2+ binding site [ion binding]; other site
176299013844	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299013845	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299013846	DNA binding site [nucleotide binding]
176299013847	domain linker motif; other site
176299013848	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
176299013849	putative dimerization interface [polypeptide binding]; other site
176299013850	putative ligand binding site [chemical binding]; other site
176299013851	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
176299013852	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
176299013853	putative ligand binding site [chemical binding]; other site
176299013854	NAD binding site [chemical binding]; other site
176299013855	catalytic site [active]
176299013856	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299013857	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299013858	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299013859	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
176299013860	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299013861	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299013862	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
176299013863	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
176299013864	PYR/PP interface [polypeptide binding]; other site
176299013865	dimer interface [polypeptide binding]; other site
176299013866	TPP binding site [chemical binding]; other site
176299013867	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
176299013868	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
176299013869	TPP-binding site [chemical binding]; other site
176299013870	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
176299013871	substrate binding site [chemical binding]; other site
176299013872	ATP binding site [chemical binding]; other site
176299013873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
176299013874	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
176299013875	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
176299013876	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
176299013877	putative active site [active]
176299013878	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
176299013879	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
176299013880	Walker A/P-loop; other site
176299013881	ATP binding site [chemical binding]; other site
176299013882	Q-loop/lid; other site
176299013883	ABC transporter signature motif; other site
176299013884	Walker B; other site
176299013885	D-loop; other site
176299013886	H-loop/switch region; other site
176299013887	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
176299013888	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
176299013889	Walker A/P-loop; other site
176299013890	ATP binding site [chemical binding]; other site
176299013891	Q-loop/lid; other site
176299013892	ABC transporter signature motif; other site
176299013893	Walker B; other site
176299013894	D-loop; other site
176299013895	H-loop/switch region; other site
176299013896	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
176299013897	TM-ABC transporter signature motif; other site
176299013898	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299013899	TM-ABC transporter signature motif; other site
176299013900	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
176299013901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299013902	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299013903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
176299013904	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_5; cd06232
176299013905	putative active site [active]
176299013906	Zn binding site [ion binding]; other site
176299013907	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299013908	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013909	dimer interface [polypeptide binding]; other site
176299013910	conserved gate region; other site
176299013911	putative PBP binding loops; other site
176299013912	ABC-ATPase subunit interface; other site
176299013913	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299013914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013915	dimer interface [polypeptide binding]; other site
176299013916	conserved gate region; other site
176299013917	putative PBP binding loops; other site
176299013918	ABC-ATPase subunit interface; other site
176299013919	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299013920	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
176299013921	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299013922	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299013923	Walker A/P-loop; other site
176299013924	ATP binding site [chemical binding]; other site
176299013925	Q-loop/lid; other site
176299013926	ABC transporter signature motif; other site
176299013927	Walker B; other site
176299013928	D-loop; other site
176299013929	H-loop/switch region; other site
176299013930	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299013931	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299013932	Walker A/P-loop; other site
176299013933	ATP binding site [chemical binding]; other site
176299013934	Q-loop/lid; other site
176299013935	ABC transporter signature motif; other site
176299013936	Walker B; other site
176299013937	D-loop; other site
176299013938	H-loop/switch region; other site
176299013939	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299013940	Uncharacterized conserved protein [Function unknown]; Region: COG1359
176299013941	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299013942	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299013943	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
176299013944	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
176299013945	dimer interface [polypeptide binding]; other site
176299013946	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
176299013947	active site
176299013948	Fe binding site [ion binding]; other site
176299013949	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299013950	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299013951	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
176299013952	trimer interface [polypeptide binding]; other site
176299013953	active site
176299013954	dimer interface [polypeptide binding]; other site
176299013955	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
176299013956	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
176299013957	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
176299013958	shikimate binding site; other site
176299013959	NAD(P) binding site [chemical binding]; other site
176299013960	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299013961	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299013962	Walker A/P-loop; other site
176299013963	ATP binding site [chemical binding]; other site
176299013964	Q-loop/lid; other site
176299013965	ABC transporter signature motif; other site
176299013966	Walker B; other site
176299013967	D-loop; other site
176299013968	H-loop/switch region; other site
176299013969	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299013970	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299013971	substrate binding pocket [chemical binding]; other site
176299013972	membrane-bound complex binding site; other site
176299013973	hinge residues; other site
176299013974	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299013975	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299013976	substrate binding pocket [chemical binding]; other site
176299013977	membrane-bound complex binding site; other site
176299013978	hinge residues; other site
176299013979	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299013980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013981	dimer interface [polypeptide binding]; other site
176299013982	conserved gate region; other site
176299013983	putative PBP binding loops; other site
176299013984	ABC-ATPase subunit interface; other site
176299013985	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299013986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299013987	dimer interface [polypeptide binding]; other site
176299013988	conserved gate region; other site
176299013989	putative PBP binding loops; other site
176299013990	ABC-ATPase subunit interface; other site
176299013991	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
176299013992	Lyase; Region: Lyase_1; pfam00206
176299013993	tetramer interface [polypeptide binding]; other site
176299013994	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
176299013995	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
176299013996	heterodimer interface [polypeptide binding]; other site
176299013997	active site
176299013998	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
176299013999	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
176299014000	active site
176299014001	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
176299014002	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
176299014003	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299014004	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
176299014005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299014006	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299014007	dimerization interface [polypeptide binding]; other site
176299014008	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
176299014009	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
176299014010	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
176299014011	Cupin domain; Region: Cupin_2; cl17218
176299014012	Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363
176299014013	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299014014	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
176299014015	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
176299014016	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299014017	Coenzyme A transferase; Region: CoA_trans; cl17247
176299014018	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
176299014019	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
176299014020	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
176299014021	dimer interface [polypeptide binding]; other site
176299014022	active site
176299014023	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299014024	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299014025	DNA binding site [nucleotide binding]
176299014026	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
176299014027	putative ligand binding site [chemical binding]; other site
176299014028	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
176299014029	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299014030	putative ligand binding site [chemical binding]; other site
176299014031	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299014032	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
176299014033	putative ligand binding site [chemical binding]; other site
176299014034	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299014035	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299014036	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299014037	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299014038	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299014039	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
176299014040	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299014041	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299014042	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299014043	DNA binding site [nucleotide binding]
176299014044	domain linker motif; other site
176299014045	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
176299014046	ligand binding site [chemical binding]; other site
176299014047	dimerization interface [polypeptide binding]; other site
176299014048	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299014049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014050	dimer interface [polypeptide binding]; other site
176299014051	conserved gate region; other site
176299014052	putative PBP binding loops; other site
176299014053	ABC-ATPase subunit interface; other site
176299014054	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299014055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014056	dimer interface [polypeptide binding]; other site
176299014057	conserved gate region; other site
176299014058	putative PBP binding loops; other site
176299014059	ABC-ATPase subunit interface; other site
176299014060	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299014061	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299014062	Walker A/P-loop; other site
176299014063	ATP binding site [chemical binding]; other site
176299014064	Q-loop/lid; other site
176299014065	ABC transporter signature motif; other site
176299014066	Walker B; other site
176299014067	D-loop; other site
176299014068	H-loop/switch region; other site
176299014069	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
176299014070	Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188
176299014071	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
176299014072	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299014073	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299014074	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
176299014075	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
176299014076	active site
176299014077	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
176299014078	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
176299014079	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
176299014080	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299014081	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299014082	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
176299014083	nucleotide binding site [chemical binding]; other site
176299014084	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
176299014085	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299014086	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299014087	Walker A/P-loop; other site
176299014088	ATP binding site [chemical binding]; other site
176299014089	Q-loop/lid; other site
176299014090	ABC transporter signature motif; other site
176299014091	Walker B; other site
176299014092	D-loop; other site
176299014093	H-loop/switch region; other site
176299014094	TOBE domain; Region: TOBE_2; pfam08402
176299014095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014096	dimer interface [polypeptide binding]; other site
176299014097	conserved gate region; other site
176299014098	putative PBP binding loops; other site
176299014099	ABC-ATPase subunit interface; other site
176299014100	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299014101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014102	dimer interface [polypeptide binding]; other site
176299014103	conserved gate region; other site
176299014104	putative PBP binding loops; other site
176299014105	ABC-ATPase subunit interface; other site
176299014106	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
176299014107	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
176299014108	putative active site [active]
176299014109	catalytic site [active]
176299014110	putative metal binding site [ion binding]; other site
176299014111	oligomer interface [polypeptide binding]; other site
176299014112	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
176299014113	active site
176299014114	short chain dehydrogenase; Provisional; Region: PRK06180
176299014115	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
176299014116	NADP binding site [chemical binding]; other site
176299014117	active site
176299014118	steroid binding site; other site
176299014119	Cupin; Region: Cupin_6; pfam12852
176299014120	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299014121	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299014122	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299014123	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299014124	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
176299014125	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299014126	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299014127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299014128	Walker A/P-loop; other site
176299014129	ATP binding site [chemical binding]; other site
176299014130	Q-loop/lid; other site
176299014131	ABC transporter signature motif; other site
176299014132	Walker B; other site
176299014133	D-loop; other site
176299014134	H-loop/switch region; other site
176299014135	TOBE domain; Region: TOBE_2; pfam08402
176299014136	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
176299014137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014138	dimer interface [polypeptide binding]; other site
176299014139	conserved gate region; other site
176299014140	putative PBP binding loops; other site
176299014141	ABC-ATPase subunit interface; other site
176299014142	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014143	dimer interface [polypeptide binding]; other site
176299014144	conserved gate region; other site
176299014145	putative PBP binding loops; other site
176299014146	ABC-ATPase subunit interface; other site
176299014147	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
176299014148	Ferredoxin [Energy production and conversion]; Region: COG1146
176299014149	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
176299014150	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
176299014151	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
176299014152	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
176299014153	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
176299014154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299014155	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
176299014156	folate binding site [chemical binding]; other site
176299014157	NADP+ binding site [chemical binding]; other site
176299014158	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
176299014159	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
176299014160	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
176299014161	Sodium Bile acid symporter family; Region: SBF; cl19217
176299014162	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299014163	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299014164	active site
176299014165	catalytic tetrad [active]
176299014166	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299014167	LysR family transcriptional regulator; Provisional; Region: PRK14997
176299014168	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299014169	dimerization interface [polypeptide binding]; other site
176299014170	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
176299014171	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
176299014172	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
176299014173	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299014174	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299014175	NAD(P) binding site [chemical binding]; other site
176299014176	active site
176299014177	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299014178	NMT1/THI5 like; Region: NMT1; pfam09084
176299014179	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299014180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014181	dimer interface [polypeptide binding]; other site
176299014182	conserved gate region; other site
176299014183	putative PBP binding loops; other site
176299014184	ABC-ATPase subunit interface; other site
176299014185	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299014186	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299014187	Walker A/P-loop; other site
176299014188	ATP binding site [chemical binding]; other site
176299014189	Q-loop/lid; other site
176299014190	ABC transporter signature motif; other site
176299014191	Walker B; other site
176299014192	D-loop; other site
176299014193	H-loop/switch region; other site
176299014194	Transcriptional regulator [Transcription]; Region: IclR; COG1414
176299014195	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
176299014196	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299014197	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
176299014198	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299014199	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299014200	Walker A/P-loop; other site
176299014201	ATP binding site [chemical binding]; other site
176299014202	Q-loop/lid; other site
176299014203	ABC transporter signature motif; other site
176299014204	Walker B; other site
176299014205	D-loop; other site
176299014206	H-loop/switch region; other site
176299014207	HTH-like domain; Region: HTH_21; pfam13276
176299014208	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
176299014209	Integrase core domain; Region: rve; pfam00665
176299014210	Integrase core domain; Region: rve_3; pfam13683
176299014211	Transposase; Region: HTH_Tnp_1; cl17663
176299014212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299014213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299014214	Transposase; Region: HTH_Tnp_1; cl17663
176299014215	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
176299014216	HTH-like domain; Region: HTH_21; pfam13276
176299014217	Integrase core domain; Region: rve; pfam00665
176299014218	Integrase core domain; Region: rve_3; pfam13683
176299014219	Transposase; Region: HTH_Tnp_1; pfam01527
176299014220	Lipopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: RgpF; COG3754
176299014221	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
176299014222	trimer interface [polypeptide binding]; other site
176299014223	active site
176299014224	substrate binding site [chemical binding]; other site
176299014225	CoA binding site [chemical binding]; other site
176299014226	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
176299014227	Methyltransferase domain; Region: Methyltransf_23; pfam13489
176299014228	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
176299014229	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299014230	active site
176299014231	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
176299014232	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299014233	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299014234	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299014235	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299014236	NAD(P) binding site [chemical binding]; other site
176299014237	active site
176299014238	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
176299014239	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
176299014240	active site
176299014241	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
176299014242	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299014243	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
176299014244	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
176299014245	Probable Catalytic site; other site
176299014246	metal-binding site
176299014247	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
176299014248	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
176299014249	substrate binding site; other site
176299014250	tetramer interface; other site
176299014251	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
176299014252	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
176299014253	NADP binding site [chemical binding]; other site
176299014254	active site
176299014255	putative substrate binding site [chemical binding]; other site
176299014256	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
176299014257	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
176299014258	NAD binding site [chemical binding]; other site
176299014259	substrate binding site [chemical binding]; other site
176299014260	homodimer interface [polypeptide binding]; other site
176299014261	active site
176299014262	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
176299014263	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
176299014264	Part of AAA domain; Region: AAA_19; pfam13245
176299014265	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
176299014266	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299014267	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014268	Walker A/P-loop; other site
176299014269	ATP binding site [chemical binding]; other site
176299014270	Q-loop/lid; other site
176299014271	ABC transporter signature motif; other site
176299014272	Walker B; other site
176299014273	D-loop; other site
176299014274	H-loop/switch region; other site
176299014275	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
176299014276	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014277	Walker A/P-loop; other site
176299014278	ATP binding site [chemical binding]; other site
176299014279	Q-loop/lid; other site
176299014280	ABC transporter signature motif; other site
176299014281	Walker B; other site
176299014282	D-loop; other site
176299014283	H-loop/switch region; other site
176299014284	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299014285	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299014286	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299014287	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014288	dimer interface [polypeptide binding]; other site
176299014289	conserved gate region; other site
176299014290	putative PBP binding loops; other site
176299014291	ABC-ATPase subunit interface; other site
176299014292	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299014293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014294	dimer interface [polypeptide binding]; other site
176299014295	conserved gate region; other site
176299014296	putative PBP binding loops; other site
176299014297	ABC-ATPase subunit interface; other site
176299014298	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299014299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299014300	DNA-binding site [nucleotide binding]; DNA binding site
176299014301	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299014302	D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312
176299014303	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
176299014304	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299014305	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
176299014306	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
176299014307	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
176299014308	Acyltransferase family; Region: Acyl_transf_3; cl19154
176299014309	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
176299014310	PAS domain S-box; Region: sensory_box; TIGR00229
176299014311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299014312	putative active site [active]
176299014313	heme pocket [chemical binding]; other site
176299014314	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299014315	metal binding site [ion binding]; metal-binding site
176299014316	active site
176299014317	I-site; other site
176299014318	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299014319	oxidoreductase; Provisional; Region: PRK06128
176299014320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299014321	NAD(P) binding site [chemical binding]; other site
176299014322	active site
176299014323	C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973
176299014324	putative activation loop; other site
176299014325	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
176299014326	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
176299014327	putative DNA binding site [nucleotide binding]; other site
176299014328	putative homodimer interface [polypeptide binding]; other site
176299014329	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
176299014330	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
176299014331	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
176299014332	active site
176299014333	DNA binding site [nucleotide binding]
176299014334	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
176299014335	DNA binding site [nucleotide binding]
176299014336	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
176299014337	nucleotide binding site [chemical binding]; other site
176299014338	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
176299014339	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
176299014340	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
176299014341	nudix motif; other site
176299014342	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299014343	MMPL family; Region: MMPL; cl14618
176299014344	MMPL family; Region: MMPL; cl14618
176299014345	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299014346	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299014347	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299014348	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299014349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299014350	active site
176299014351	phosphorylation site [posttranslational modification]
176299014352	intermolecular recognition site; other site
176299014353	dimerization interface [polypeptide binding]; other site
176299014354	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299014355	DNA binding site [nucleotide binding]
176299014356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299014357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299014358	dimer interface [polypeptide binding]; other site
176299014359	phosphorylation site [posttranslational modification]
176299014360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299014361	ATP binding site [chemical binding]; other site
176299014362	Mg2+ binding site [ion binding]; other site
176299014363	G-X-G motif; other site
176299014364	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
176299014365	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299014366	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
176299014367	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
176299014368	dimerization interface [polypeptide binding]; other site
176299014369	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
176299014370	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
176299014371	heme binding site [chemical binding]; other site
176299014372	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
176299014373	heme binding site [chemical binding]; other site
176299014374	Cupin; Region: Cupin_6; pfam12852
176299014375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299014376	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299014377	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
176299014378	NAD(P) binding site [chemical binding]; other site
176299014379	catalytic residues [active]
176299014380	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
176299014381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299014382	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299014383	dimerization interface [polypeptide binding]; other site
176299014384	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
176299014385	choline-sulfatase; Region: chol_sulfatase; TIGR03417
176299014386	Sulfatase; Region: Sulfatase; pfam00884
176299014387	C-terminal region of aryl-sulfatase; Region: Sulfatase_C; pfam14707
176299014388	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
176299014389	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
176299014390	ATP binding site [chemical binding]; other site
176299014391	substrate binding site [chemical binding]; other site
176299014392	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299014393	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299014394	Walker A/P-loop; other site
176299014395	ATP binding site [chemical binding]; other site
176299014396	Q-loop/lid; other site
176299014397	ABC transporter signature motif; other site
176299014398	Walker B; other site
176299014399	D-loop; other site
176299014400	H-loop/switch region; other site
176299014401	TOBE domain; Region: TOBE_2; pfam08402
176299014402	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
176299014403	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
176299014404	active sites [active]
176299014405	tetramer interface [polypeptide binding]; other site
176299014406	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299014407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014408	dimer interface [polypeptide binding]; other site
176299014409	conserved gate region; other site
176299014410	putative PBP binding loops; other site
176299014411	ABC-ATPase subunit interface; other site
176299014412	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
176299014413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014414	dimer interface [polypeptide binding]; other site
176299014415	conserved gate region; other site
176299014416	putative PBP binding loops; other site
176299014417	ABC-ATPase subunit interface; other site
176299014418	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299014419	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299014420	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299014421	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
176299014422	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
176299014423	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299014424	EamA-like transporter family; Region: EamA; pfam00892
176299014425	EamA-like transporter family; Region: EamA; pfam00892
176299014426	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
176299014427	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299014428	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299014429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299014430	alpha-galactosidase; Provisional; Region: PRK15076
176299014431	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
176299014432	NAD binding site [chemical binding]; other site
176299014433	sugar binding site [chemical binding]; other site
176299014434	divalent metal binding site [ion binding]; other site
176299014435	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
176299014436	dimer interface [polypeptide binding]; other site
176299014437	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
176299014438	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299014439	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299014440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014441	dimer interface [polypeptide binding]; other site
176299014442	conserved gate region; other site
176299014443	putative PBP binding loops; other site
176299014444	ABC-ATPase subunit interface; other site
176299014445	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299014446	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014447	dimer interface [polypeptide binding]; other site
176299014448	conserved gate region; other site
176299014449	putative PBP binding loops; other site
176299014450	ABC-ATPase subunit interface; other site
176299014451	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
176299014452	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014453	Walker A/P-loop; other site
176299014454	ATP binding site [chemical binding]; other site
176299014455	Q-loop/lid; other site
176299014456	ABC transporter signature motif; other site
176299014457	Walker B; other site
176299014458	D-loop; other site
176299014459	H-loop/switch region; other site
176299014460	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299014461	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014462	Walker A/P-loop; other site
176299014463	ATP binding site [chemical binding]; other site
176299014464	Q-loop/lid; other site
176299014465	ABC transporter signature motif; other site
176299014466	Walker B; other site
176299014467	D-loop; other site
176299014468	H-loop/switch region; other site
176299014469	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299014470	alpha-galactosidase; Provisional; Region: PRK15076
176299014471	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
176299014472	NAD binding site [chemical binding]; other site
176299014473	sugar binding site [chemical binding]; other site
176299014474	divalent metal binding site [ion binding]; other site
176299014475	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
176299014476	dimer interface [polypeptide binding]; other site
176299014477	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
176299014478	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299014479	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299014480	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299014481	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
176299014482	Walker A/P-loop; other site
176299014483	ATP binding site [chemical binding]; other site
176299014484	Q-loop/lid; other site
176299014485	ABC transporter signature motif; other site
176299014486	Walker B; other site
176299014487	D-loop; other site
176299014488	H-loop/switch region; other site
176299014489	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
176299014490	Walker A/P-loop; other site
176299014491	ATP binding site [chemical binding]; other site
176299014492	Q-loop/lid; other site
176299014493	ABC transporter signature motif; other site
176299014494	Walker B; other site
176299014495	D-loop; other site
176299014496	H-loop/switch region; other site
176299014497	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
176299014498	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
176299014499	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
176299014500	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
176299014501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299014502	active site
176299014503	phosphorylation site [posttranslational modification]
176299014504	intermolecular recognition site; other site
176299014505	dimerization interface [polypeptide binding]; other site
176299014506	cell division protein FtsZ; Validated; Region: PRK09330
176299014507	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
176299014508	nucleotide binding site [chemical binding]; other site
176299014509	SulA interaction site; other site
176299014510	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299014511	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299014512	DNA-binding site [nucleotide binding]; DNA binding site
176299014513	FCD domain; Region: FCD; pfam07729
176299014514	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299014515	inhibitor site; inhibition site
176299014516	active site
176299014517	dimer interface [polypeptide binding]; other site
176299014518	catalytic residue [active]
176299014519	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
176299014520	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299014521	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299014522	substrate binding pocket [chemical binding]; other site
176299014523	membrane-bound complex binding site; other site
176299014524	hinge residues; other site
176299014525	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299014526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014527	dimer interface [polypeptide binding]; other site
176299014528	conserved gate region; other site
176299014529	putative PBP binding loops; other site
176299014530	ABC-ATPase subunit interface; other site
176299014531	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299014532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014533	dimer interface [polypeptide binding]; other site
176299014534	conserved gate region; other site
176299014535	putative PBP binding loops; other site
176299014536	ABC-ATPase subunit interface; other site
176299014537	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299014538	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299014539	Walker A/P-loop; other site
176299014540	ATP binding site [chemical binding]; other site
176299014541	Q-loop/lid; other site
176299014542	ABC transporter signature motif; other site
176299014543	Walker B; other site
176299014544	D-loop; other site
176299014545	H-loop/switch region; other site
176299014546	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299014547	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299014548	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
176299014549	NAD binding site [chemical binding]; other site
176299014550	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299014551	Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure...; Region: AcnX_swivel; cd01356
176299014552	substrate binding site [chemical binding]; other site
176299014553	Putative Aconitase X catalytic domain; Region: AcnX; cd01355
176299014554	substrate binding site [chemical binding]; other site
176299014555	ligand binding site [chemical binding]; other site
176299014556	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
176299014557	hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687
176299014558	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299014559	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299014560	DNA binding site [nucleotide binding]
176299014561	domain linker motif; other site
176299014562	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
176299014563	putative dimerization interface [polypeptide binding]; other site
176299014564	putative ligand binding site [chemical binding]; other site
176299014565	Restriction endonuclease NaeI; Region: NaeI; pfam09126
176299014566	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299014567	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299014568	substrate binding pocket [chemical binding]; other site
176299014569	membrane-bound complex binding site; other site
176299014570	hinge residues; other site
176299014571	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299014572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014573	dimer interface [polypeptide binding]; other site
176299014574	conserved gate region; other site
176299014575	putative PBP binding loops; other site
176299014576	ABC-ATPase subunit interface; other site
176299014577	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299014578	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014579	dimer interface [polypeptide binding]; other site
176299014580	conserved gate region; other site
176299014581	putative PBP binding loops; other site
176299014582	ABC-ATPase subunit interface; other site
176299014583	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
176299014584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299014585	Walker A/P-loop; other site
176299014586	ATP binding site [chemical binding]; other site
176299014587	Q-loop/lid; other site
176299014588	ABC transporter signature motif; other site
176299014589	Walker B; other site
176299014590	D-loop; other site
176299014591	H-loop/switch region; other site
176299014592	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
176299014593	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
176299014594	putative ligand binding site [chemical binding]; other site
176299014595	NAD binding site [chemical binding]; other site
176299014596	catalytic site [active]
176299014597	PAS fold; Region: PAS_4; pfam08448
176299014598	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299014599	putative active site [active]
176299014600	heme pocket [chemical binding]; other site
176299014601	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299014602	metal binding site [ion binding]; metal-binding site
176299014603	active site
176299014604	I-site; other site
176299014605	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299014606	Porin subfamily; Region: Porin_2; pfam02530
176299014607	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
176299014608	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
176299014609	active site
176299014610	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299014611	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
176299014612	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299014613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014614	dimer interface [polypeptide binding]; other site
176299014615	conserved gate region; other site
176299014616	putative PBP binding loops; other site
176299014617	ABC-ATPase subunit interface; other site
176299014618	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299014619	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299014620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014621	dimer interface [polypeptide binding]; other site
176299014622	conserved gate region; other site
176299014623	putative PBP binding loops; other site
176299014624	ABC-ATPase subunit interface; other site
176299014625	cytosine deaminase; Provisional; Region: PRK05985
176299014626	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
176299014627	active site
176299014628	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06151
176299014629	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
176299014630	active site
176299014631	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
176299014632	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014633	Walker A/P-loop; other site
176299014634	ATP binding site [chemical binding]; other site
176299014635	Q-loop/lid; other site
176299014636	ABC transporter signature motif; other site
176299014637	Walker B; other site
176299014638	D-loop; other site
176299014639	H-loop/switch region; other site
176299014640	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299014641	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
176299014642	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014643	Walker A/P-loop; other site
176299014644	ATP binding site [chemical binding]; other site
176299014645	Q-loop/lid; other site
176299014646	ABC transporter signature motif; other site
176299014647	Walker B; other site
176299014648	D-loop; other site
176299014649	H-loop/switch region; other site
176299014650	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299014651	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299014652	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299014653	DNA-binding site [nucleotide binding]; DNA binding site
176299014654	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299014655	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
176299014656	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
176299014657	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299014658	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299014659	Phage protein; Region: DUF3653; pfam12375
176299014660	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
176299014661	dimerization interface [polypeptide binding]; other site
176299014662	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
176299014663	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
176299014664	putative dimer interface [polypeptide binding]; other site
176299014665	[2Fe-2S] cluster binding site [ion binding]; other site
176299014666	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
176299014667	putative dimer interface [polypeptide binding]; other site
176299014668	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
176299014669	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
176299014670	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
176299014671	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
176299014672	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299014673	catalytic loop [active]
176299014674	iron binding site [ion binding]; other site
176299014675	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
176299014676	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
176299014677	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
176299014678	[4Fe-4S] binding site [ion binding]; other site
176299014679	molybdopterin cofactor binding site; other site
176299014680	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
176299014681	molybdopterin cofactor binding site; other site
176299014682	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
176299014683	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299014684	putative substrate translocation pore; other site
176299014685	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299014686	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
176299014687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299014688	ATP binding site [chemical binding]; other site
176299014689	Mg2+ binding site [ion binding]; other site
176299014690	G-X-G motif; other site
176299014691	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299014692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299014693	active site
176299014694	phosphorylation site [posttranslational modification]
176299014695	intermolecular recognition site; other site
176299014696	dimerization interface [polypeptide binding]; other site
176299014697	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299014698	DNA binding site [nucleotide binding]
176299014699	Protein of unknown function (DUF992); Region: DUF992; pfam06186
176299014700	BON domain; Region: BON; pfam04972
176299014701	CsbD-like; Region: CsbD; pfam05532
176299014702	PAS fold; Region: PAS_4; pfam08448
176299014703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299014704	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299014705	putative active site [active]
176299014706	heme pocket [chemical binding]; other site
176299014707	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299014708	putative active site [active]
176299014709	heme pocket [chemical binding]; other site
176299014710	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299014711	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299014712	DNA binding residues [nucleotide binding]
176299014713	dimerization interface [polypeptide binding]; other site
176299014714	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299014715	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299014716	DNA-binding site [nucleotide binding]; DNA binding site
176299014717	FCD domain; Region: FCD; pfam07729
176299014718	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299014719	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511
176299014720	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299014721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014722	dimer interface [polypeptide binding]; other site
176299014723	conserved gate region; other site
176299014724	putative PBP binding loops; other site
176299014725	ABC-ATPase subunit interface; other site
176299014726	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299014727	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299014728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014729	dimer interface [polypeptide binding]; other site
176299014730	conserved gate region; other site
176299014731	putative PBP binding loops; other site
176299014732	ABC-ATPase subunit interface; other site
176299014733	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
176299014734	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299014735	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014736	Walker A/P-loop; other site
176299014737	ATP binding site [chemical binding]; other site
176299014738	Q-loop/lid; other site
176299014739	ABC transporter signature motif; other site
176299014740	Walker B; other site
176299014741	D-loop; other site
176299014742	H-loop/switch region; other site
176299014743	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299014744	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299014745	Walker A/P-loop; other site
176299014746	ATP binding site [chemical binding]; other site
176299014747	Q-loop/lid; other site
176299014748	ABC transporter signature motif; other site
176299014749	Walker B; other site
176299014750	D-loop; other site
176299014751	H-loop/switch region; other site
176299014752	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
176299014753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
176299014754	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
176299014755	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
176299014756	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
176299014757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
176299014758	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
176299014759	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
176299014760	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299014761	Walker A/P-loop; other site
176299014762	ATP binding site [chemical binding]; other site
176299014763	Q-loop/lid; other site
176299014764	ABC transporter signature motif; other site
176299014765	Walker B; other site
176299014766	D-loop; other site
176299014767	H-loop/switch region; other site
176299014768	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
176299014769	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299014770	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
176299014771	AAA ATPase domain; Region: AAA_16; pfam13191
176299014772	Spore Coat Protein U domain; Region: SCPU; pfam05229
176299014773	Uncharacterized secreted protein [Function unknown]; Region: COG5430
176299014774	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
176299014775	PapC N-terminal domain; Region: PapC_N; pfam13954
176299014776	Outer membrane usher protein; Region: Usher; pfam00577
176299014777	PapC C-terminal domain; Region: PapC_C; pfam13953
176299014778	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
176299014779	Pili and flagellar-assembly chaperone, PapD N-terminal domain; Region: PapD_N; pfam00345
176299014780	Uncharacterized secreted protein [Function unknown]; Region: COG5430
176299014781	Aconitase B [Energy production and conversion]; Region: AcnB; COG1049
176299014782	Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791
176299014783	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
176299014784	substrate binding site [chemical binding]; other site
176299014785	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
176299014786	substrate binding site [chemical binding]; other site
176299014787	ligand binding site [chemical binding]; other site
176299014788	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299014789	dimerization interface [polypeptide binding]; other site
176299014790	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299014791	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299014792	dimer interface [polypeptide binding]; other site
176299014793	putative CheW interface [polypeptide binding]; other site
176299014794	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
176299014795	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
176299014796	trimer interface [polypeptide binding]; other site
176299014797	active site
176299014798	substrate binding site [chemical binding]; other site
176299014799	CoA binding site [chemical binding]; other site
176299014800	SnoaL-like domain; Region: SnoaL_2; pfam12680
176299014801	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
176299014802	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
176299014803	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
176299014804	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
176299014805	putative NAD(P) binding site [chemical binding]; other site
176299014806	catalytic Zn binding site [ion binding]; other site
176299014807	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
176299014808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299014809	Walker A motif; other site
176299014810	ATP binding site [chemical binding]; other site
176299014811	Walker B motif; other site
176299014812	arginine finger; other site
176299014813	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
176299014814	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
176299014815	TPR motif; other site
176299014816	binding surface
176299014817	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299014818	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299014819	DNA binding site [nucleotide binding]
176299014820	domain linker motif; other site
176299014821	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
176299014822	dimerization interface [polypeptide binding]; other site
176299014823	ligand binding site [chemical binding]; other site
176299014824	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
176299014825	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299014826	ligand binding site [chemical binding]; other site
176299014827	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299014828	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299014829	Walker A/P-loop; other site
176299014830	ATP binding site [chemical binding]; other site
176299014831	Q-loop/lid; other site
176299014832	ABC transporter signature motif; other site
176299014833	Walker B; other site
176299014834	D-loop; other site
176299014835	H-loop/switch region; other site
176299014836	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299014837	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299014838	TM-ABC transporter signature motif; other site
176299014839	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299014840	TM-ABC transporter signature motif; other site
176299014841	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299014842	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299014843	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
176299014844	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
176299014845	active site
176299014846	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299014847	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299014848	ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005
176299014849	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299014850	Walker A/P-loop; other site
176299014851	ATP binding site [chemical binding]; other site
176299014852	Q-loop/lid; other site
176299014853	ABC transporter signature motif; other site
176299014854	Walker B; other site
176299014855	D-loop; other site
176299014856	H-loop/switch region; other site
176299014857	ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003
176299014858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014859	dimer interface [polypeptide binding]; other site
176299014860	conserved gate region; other site
176299014861	putative PBP binding loops; other site
176299014862	ABC-ATPase subunit interface; other site
176299014863	ectoine/hydroxyectoine ABC transporter, permease protein EhuC; Region: ectoine_ehuC; TIGR03004
176299014864	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014865	dimer interface [polypeptide binding]; other site
176299014866	conserved gate region; other site
176299014867	putative PBP binding loops; other site
176299014868	ABC-ATPase subunit interface; other site
176299014869	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
176299014870	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299014871	substrate binding pocket [chemical binding]; other site
176299014872	membrane-bound complex binding site; other site
176299014873	hinge residues; other site
176299014874	ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994
176299014875	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252
176299014876	putative active site [active]
176299014877	Zn binding site [ion binding]; other site
176299014878	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
176299014879	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299014880	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
176299014881	active site
176299014882	ectoine utilization protein EutC; Validated; Region: PRK08291
176299014883	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124
176299014884	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
176299014885	tetramer interface [polypeptide binding]; other site
176299014886	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299014887	catalytic residue [active]
176299014888	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
176299014889	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299014890	DNA-binding site [nucleotide binding]; DNA binding site
176299014891	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
176299014892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299014893	homodimer interface [polypeptide binding]; other site
176299014894	catalytic residue [active]
176299014895	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299014896	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299014897	inhibitor-cofactor binding pocket; inhibition site
176299014898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299014899	catalytic residue [active]
176299014900	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
176299014901	tetramerization interface [polypeptide binding]; other site
176299014902	NAD(P) binding site [chemical binding]; other site
176299014903	catalytic residues [active]
176299014904	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299014905	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299014906	putative DNA binding site [nucleotide binding]; other site
176299014907	putative Zn2+ binding site [ion binding]; other site
176299014908	AsnC family; Region: AsnC_trans_reg; pfam01037
176299014909	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
176299014910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299014911	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
176299014912	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
176299014913	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
176299014914	major curlin subunit; Provisional; Region: csgA; PRK10051
176299014915	Curlin associated repeat; Region: Curlin_rpt; pfam07012
176299014916	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
176299014917	hypothetical protein; Provisional; Region: PRK07236
176299014918	putative monooxygenase; Reviewed; Region: PRK07045
176299014919	bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404
176299014920	Cupin; Region: Cupin_1; smart00835
176299014921	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
176299014922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299014923	active site
176299014924	phosphorylation site [posttranslational modification]
176299014925	intermolecular recognition site; other site
176299014926	dimerization interface [polypeptide binding]; other site
176299014927	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
176299014928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299014929	active site
176299014930	phosphorylation site [posttranslational modification]
176299014931	intermolecular recognition site; other site
176299014932	dimerization interface [polypeptide binding]; other site
176299014933	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299014934	DNA binding residues [nucleotide binding]
176299014935	dimerization interface [polypeptide binding]; other site
176299014936	PAS domain; Region: PAS_9; pfam13426
176299014937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299014938	dimer interface [polypeptide binding]; other site
176299014939	phosphorylation site [posttranslational modification]
176299014940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299014941	ATP binding site [chemical binding]; other site
176299014942	Mg2+ binding site [ion binding]; other site
176299014943	G-X-G motif; other site
176299014944	putative oxidoreductase; Provisional; Region: PRK09939
176299014945	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
176299014946	putative molybdopterin cofactor binding site [chemical binding]; other site
176299014947	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
176299014948	putative molybdopterin cofactor binding site; other site
176299014949	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
176299014950	Ferritin-like domain; Region: Ferritin; pfam00210
176299014951	dimerization interface [polypeptide binding]; other site
176299014952	DPS ferroxidase diiron center [ion binding]; other site
176299014953	ion pore; other site
176299014954	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299014955	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299014956	Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
176299014957	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
176299014958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299014959	dimer interface [polypeptide binding]; other site
176299014960	phosphorylation site [posttranslational modification]
176299014961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299014962	ATP binding site [chemical binding]; other site
176299014963	Mg2+ binding site [ion binding]; other site
176299014964	G-X-G motif; other site
176299014965	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299014966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299014967	active site
176299014968	phosphorylation site [posttranslational modification]
176299014969	intermolecular recognition site; other site
176299014970	dimerization interface [polypeptide binding]; other site
176299014971	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299014972	DNA binding site [nucleotide binding]
176299014973	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299014974	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
176299014975	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
176299014976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014977	dimer interface [polypeptide binding]; other site
176299014978	conserved gate region; other site
176299014979	putative PBP binding loops; other site
176299014980	ABC-ATPase subunit interface; other site
176299014981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299014982	dimer interface [polypeptide binding]; other site
176299014983	conserved gate region; other site
176299014984	putative PBP binding loops; other site
176299014985	ABC-ATPase subunit interface; other site
176299014986	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299014987	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299014988	Walker A/P-loop; other site
176299014989	ATP binding site [chemical binding]; other site
176299014990	Q-loop/lid; other site
176299014991	ABC transporter signature motif; other site
176299014992	Walker B; other site
176299014993	D-loop; other site
176299014994	H-loop/switch region; other site
176299014995	TOBE domain; Region: TOBE_2; pfam08402
176299014996	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
176299014997	active site
176299014998	Methyltransferase domain; Region: Methyltransf_31; pfam13847
176299014999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299015000	S-adenosylmethionine binding site [chemical binding]; other site
176299015001	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
176299015002	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
176299015003	NADP-binding site; other site
176299015004	homotetramer interface [polypeptide binding]; other site
176299015005	substrate binding site [chemical binding]; other site
176299015006	homodimer interface [polypeptide binding]; other site
176299015007	active site
176299015008	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
176299015009	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
176299015010	NADP binding site [chemical binding]; other site
176299015011	active site
176299015012	putative substrate binding site [chemical binding]; other site
176299015013	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
176299015014	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
176299015015	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
176299015016	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
176299015017	SLBB domain; Region: SLBB; pfam10531
176299015018	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
176299015019	Chain length determinant protein; Region: Wzz; pfam02706
176299015020	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
176299015021	AAA domain; Region: AAA_31; pfam13614
176299015022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299015023	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299015024	DNA binding residues [nucleotide binding]
176299015025	dimerization interface [polypeptide binding]; other site
176299015026	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
176299015027	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
176299015028	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
176299015029	substrate binding site; other site
176299015030	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
176299015031	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299015032	S-adenosylmethionine binding site [chemical binding]; other site
176299015033	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
176299015034	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
176299015035	M28 Zn-Peptidases; Region: M28_like_3; cd05644
176299015036	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
176299015037	active site
176299015038	metal binding site [ion binding]; metal-binding site
176299015039	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299015040	extended (e) SDRs; Region: SDR_e; cd08946
176299015041	NAD(P) binding site [chemical binding]; other site
176299015042	active site
176299015043	substrate binding site [chemical binding]; other site
176299015044	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
176299015045	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945
176299015046	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299015047	catalytic residue [active]
176299015048	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299015049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
176299015050	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299015051	DNA binding residues [nucleotide binding]
176299015052	dimerization interface [polypeptide binding]; other site
176299015053	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
176299015054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299015055	dimer interface [polypeptide binding]; other site
176299015056	phosphorylation site [posttranslational modification]
176299015057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299015058	ATP binding site [chemical binding]; other site
176299015059	Mg2+ binding site [ion binding]; other site
176299015060	G-X-G motif; other site
176299015061	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299015062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299015063	active site
176299015064	phosphorylation site [posttranslational modification]
176299015065	intermolecular recognition site; other site
176299015066	dimerization interface [polypeptide binding]; other site
176299015067	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
176299015068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299015069	active site
176299015070	phosphorylation site [posttranslational modification]
176299015071	intermolecular recognition site; other site
176299015072	dimerization interface [polypeptide binding]; other site
176299015073	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299015074	DNA binding residues [nucleotide binding]
176299015075	dimerization interface [polypeptide binding]; other site
176299015076	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
176299015077	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
176299015078	active site
176299015079	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
176299015080	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
176299015081	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
176299015082	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299015083	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
176299015084	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
176299015085	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
176299015086	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
176299015087	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
176299015088	Mg++ binding site [ion binding]; other site
176299015089	putative catalytic motif [active]
176299015090	substrate binding site [chemical binding]; other site
176299015091	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
176299015092	putative active site [active]
176299015093	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
176299015094	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
176299015095	putative trimer interface [polypeptide binding]; other site
176299015096	putative active site [active]
176299015097	putative substrate binding site [chemical binding]; other site
176299015098	putative CoA binding site [chemical binding]; other site
176299015099	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299015100	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
176299015101	putative ADP-binding pocket [chemical binding]; other site
176299015102	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
176299015103	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
176299015104	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
176299015105	putative glycosyl transferase; Provisional; Region: PRK10307
176299015106	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
176299015107	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299015108	putative DNA binding site [nucleotide binding]; other site
176299015109	putative Zn2+ binding site [ion binding]; other site
176299015110	AsnC family; Region: AsnC_trans_reg; pfam01037
176299015111	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
176299015112	trimer interface [polypeptide binding]; other site
176299015113	putative Zn binding site [ion binding]; other site
176299015114	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299015115	classical (c) SDRs; Region: SDR_c; cd05233
176299015116	NAD(P) binding site [chemical binding]; other site
176299015117	active site
176299015118	acyl-CoA synthetase; Validated; Region: PRK07470
176299015119	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
176299015120	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
176299015121	acyl-activating enzyme (AAE) consensus motif; other site
176299015122	acyl-activating enzyme (AAE) consensus motif; other site
176299015123	putative AMP binding site [chemical binding]; other site
176299015124	putative active site [active]
176299015125	putative CoA binding site [chemical binding]; other site
176299015126	acetyl-CoA acetyltransferase; Provisional; Region: PRK07516
176299015127	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
176299015128	active site
176299015129	Transcriptional regulator [Transcription]; Region: IclR; COG1414
176299015130	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
176299015131	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299015132	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
176299015133	classical (c) SDRs; Region: SDR_c; cd05233
176299015134	NAD(P) binding site [chemical binding]; other site
176299015135	active site
176299015136	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
176299015137	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
176299015138	DctM-like transporters; Region: DctM; pfam06808
176299015139	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
176299015140	RES domain; Region: RES; pfam08808
176299015141	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
176299015142	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
176299015143	Domain interface; other site
176299015144	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
176299015145	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
176299015146	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
176299015147	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
176299015148	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
176299015149	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853
176299015150	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
176299015151	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
176299015152	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
176299015153	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
176299015154	nucleotide binding site [chemical binding]; other site
176299015155	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
176299015156	short chain dehydrogenase; Region: adh_short; pfam00106
176299015157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299015158	NAD(P) binding site [chemical binding]; other site
176299015159	active site
176299015160	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
176299015161	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
176299015162	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
176299015163	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
176299015164	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
176299015165	ligand binding site [chemical binding]; other site
176299015166	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299015167	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299015168	Walker A/P-loop; other site
176299015169	ATP binding site [chemical binding]; other site
176299015170	Q-loop/lid; other site
176299015171	ABC transporter signature motif; other site
176299015172	Walker B; other site
176299015173	D-loop; other site
176299015174	H-loop/switch region; other site
176299015175	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299015176	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299015177	TM-ABC transporter signature motif; other site
176299015178	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299015179	TM-ABC transporter signature motif; other site
176299015180	deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269
176299015181	active site
176299015182	catalytic residues [active]
176299015183	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
176299015184	substrate binding site [chemical binding]; other site
176299015185	dimer interface [polypeptide binding]; other site
176299015186	ATP binding site [chemical binding]; other site
176299015187	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
176299015188	intersubunit interface [polypeptide binding]; other site
176299015189	active site
176299015190	catalytic residue [active]
176299015191	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
176299015192	NAD(P) binding site [chemical binding]; other site
176299015193	catalytic residues [active]
176299015194	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
176299015195	NAD(P) binding site [chemical binding]; other site
176299015196	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
176299015197	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
176299015198	dimer interface [polypeptide binding]; other site
176299015199	active site
176299015200	oxalacetate/citrate binding site [chemical binding]; other site
176299015201	citrylCoA binding site [chemical binding]; other site
176299015202	coenzyme A binding site [chemical binding]; other site
176299015203	catalytic triad [active]
176299015204	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
176299015205	MobA/MobL family; Region: MobA_MobL; pfam03389
176299015206	AAA domain; Region: AAA_30; pfam13604
176299015207	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
176299015208	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
176299015209	active site
176299015210	NTP binding site [chemical binding]; other site
176299015211	metal binding triad [ion binding]; metal-binding site
176299015212	antibiotic binding site [chemical binding]; other site
176299015213	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
176299015214	Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms]; Region: SpoIIAA; COG1366
176299015215	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
176299015216	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
176299015217	Walker A motif; other site
176299015218	ATP binding site [chemical binding]; other site
176299015219	Walker B motif; other site
176299015220	Uncharacterized conserved protein [Function unknown]; Region: COG5397
176299015221	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
176299015222	active site
176299015223	NTP binding site [chemical binding]; other site
176299015224	metal binding triad [ion binding]; metal-binding site
176299015225	antibiotic binding site [chemical binding]; other site
176299015226	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
176299015227	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
176299015228	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299015229	Walker A motif; other site
176299015230	ATP binding site [chemical binding]; other site
176299015231	Walker B motif; other site
176299015232	arginine finger; other site
176299015233	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
176299015234	Integrase core domain; Region: rve; pfam00665
176299015235	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299015236	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
176299015237	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
176299015238	short chain dehydrogenase; Region: adh_short; pfam00106
176299015239	NADP binding site [chemical binding]; other site
176299015240	active site
176299015241	steroid binding site; other site
176299015242	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
176299015243	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
176299015244	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299015245	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299015246	active site
176299015247	catalytic tetrad [active]
176299015248	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
176299015249	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
176299015250	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
176299015251	NAD(P) binding site [chemical binding]; other site
176299015252	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299015253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015254	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
176299015255	putative effector binding pocket; other site
176299015256	putative dimerization interface [polypeptide binding]; other site
176299015257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299015258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299015259	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
176299015260	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299015261	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299015262	active site
176299015263	catalytic tetrad [active]
176299015264	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299015265	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
176299015266	NAD(P) binding site [chemical binding]; other site
176299015267	active site
176299015268	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
176299015269	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
176299015270	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299015271	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299015272	HTH DNA binding domain; Region: HTH_13; pfam11972
176299015273	Uncharacterized small protein [Function unknown]; Region: COG5475
176299015274	Helix-turn-helix domain; Region: HTH_31; pfam13560
176299015275	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299015276	non-specific DNA binding site [nucleotide binding]; other site
176299015277	sequence-specific DNA binding site [nucleotide binding]; other site
176299015278	salt bridge; other site
176299015279	HTH-like domain; Region: HTH_21; pfam13276
176299015280	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
176299015281	Integrase core domain; Region: rve; pfam00665
176299015282	Integrase core domain; Region: rve_3; pfam13683
176299015283	Transposase; Region: HTH_Tnp_1; cl17663
176299015284	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299015285	Methyltransferase domain; Region: Methyltransf_26; pfam13659
176299015286	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
176299015287	Integrase core domain; Region: rve; pfam00665
176299015288	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
176299015289	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299015290	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
176299015291	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
176299015292	MerR family regulatory protein; Region: MerR; pfam00376
176299015293	DNA binding residues [nucleotide binding]
176299015294	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
176299015295	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
176299015296	P-loop; other site
176299015297	Magnesium ion binding site [ion binding]; other site
176299015298	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
176299015299	ParB-like nuclease domain; Region: ParBc; pfam02195
176299015300	RepB plasmid partitioning protein; Region: RepB; pfam07506
176299015301	replication initiation protein RepC; Provisional; Region: PRK13824
176299015302	Replication protein C N-terminal domain; Region: RP-C; pfam03428
176299015303	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
176299015304	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299015305	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
176299015306	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299015307	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299015308	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299015309	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299015310	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299015311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015312	dimer interface [polypeptide binding]; other site
176299015313	conserved gate region; other site
176299015314	putative PBP binding loops; other site
176299015315	ABC-ATPase subunit interface; other site
176299015316	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299015317	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299015318	Walker A/P-loop; other site
176299015319	ATP binding site [chemical binding]; other site
176299015320	Q-loop/lid; other site
176299015321	ABC transporter signature motif; other site
176299015322	Walker B; other site
176299015323	D-loop; other site
176299015324	H-loop/switch region; other site
176299015325	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299015326	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299015327	substrate binding pocket [chemical binding]; other site
176299015328	membrane-bound complex binding site; other site
176299015329	hinge residues; other site
176299015330	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299015331	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299015332	DNA binding site [nucleotide binding]
176299015333	domain linker motif; other site
176299015334	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
176299015335	dimerization interface [polypeptide binding]; other site
176299015336	ligand binding site [chemical binding]; other site
176299015337	Uncharacterized conserved protein [Function unknown]; Region: COG1801
176299015338	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
176299015339	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
176299015340	catalytic residues [active]
176299015341	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
176299015342	oligomeric interface; other site
176299015343	putative active site [active]
176299015344	homodimer interface [polypeptide binding]; other site
176299015345	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
176299015346	DNA binding site [nucleotide binding]
176299015347	dimer interface [polypeptide binding]; other site
176299015348	active site
176299015349	Int/Topo IB signature motif; other site
176299015350	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
176299015351	HTH DNA binding domain; Region: HTH_13; pfam11972
176299015352	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
176299015353	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
176299015354	active site
176299015355	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
176299015356	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
176299015357	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
176299015358	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
176299015359	AAA domain; Region: AAA_23; pfam13476
176299015360	Walker A/P-loop; other site
176299015361	ATP binding site [chemical binding]; other site
176299015362	ABC transporter signature motif; other site
176299015363	AAA domain; Region: AAA_21; pfam13304
176299015364	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
176299015365	putative active site [active]
176299015366	putative metal-binding site [ion binding]; other site
176299015367	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
176299015368	Part of AAA domain; Region: AAA_19; pfam13245
176299015369	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
176299015370	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
176299015371	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
176299015372	HTH-like domain; Region: HTH_21; pfam13276
176299015373	Transposase; Region: HTH_Tnp_1; cl17663
176299015374	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299015375	Restriction endonuclease; Region: Mrr_cat; cl19295
176299015376	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
176299015377	Fic family protein [Function unknown]; Region: COG3177
176299015378	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
176299015379	Fic/DOC family; Region: Fic; pfam02661
176299015380	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
176299015381	putative DNA binding site [nucleotide binding]; other site
176299015382	putative Zn2+ binding site [ion binding]; other site
176299015383	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
176299015384	ParB-like nuclease domain; Region: ParB; smart00470
176299015385	RepB plasmid partitioning protein; Region: RepB; pfam07506
176299015386	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
176299015387	ParB-like nuclease domain; Region: ParB; smart00470
176299015388	RepB plasmid partitioning protein; Region: RepB; pfam07506
176299015389	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
176299015390	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
176299015391	catalytic residues [active]
176299015392	catalytic nucleophile [active]
176299015393	Recombinase; Region: Recombinase; pfam07508
176299015394	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
176299015395	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
176299015396	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
176299015397	putative catalytic site [active]
176299015398	putative phosphate binding site [ion binding]; other site
176299015399	active site
176299015400	metal binding site A [ion binding]; metal-binding site
176299015401	DNA binding site [nucleotide binding]
176299015402	putative AP binding site [nucleotide binding]; other site
176299015403	putative metal binding site B [ion binding]; other site
176299015404	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
176299015405	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
176299015406	putative DNA binding site [nucleotide binding]; other site
176299015407	putative homodimer interface [polypeptide binding]; other site
176299015408	Ku-homolog [Replication, recombination, and repair]; Region: COG1273
176299015409	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
176299015410	putative DNA binding site [nucleotide binding]; other site
176299015411	putative homodimer interface [polypeptide binding]; other site
176299015412	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
176299015413	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
176299015414	active site
176299015415	DNA binding site [nucleotide binding]
176299015416	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
176299015417	DNA binding site [nucleotide binding]
176299015418	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
176299015419	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
176299015420	putative dimer interface [polypeptide binding]; other site
176299015421	Protein of unknown function (DUF982); Region: DUF982; pfam06169
176299015422	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
176299015423	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
176299015424	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
176299015425	active site
176299015426	DNA binding site [nucleotide binding]
176299015427	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
176299015428	DNA binding site [nucleotide binding]
176299015429	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
176299015430	nucleotide binding site [chemical binding]; other site
176299015431	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299015432	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
176299015433	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299015434	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015435	dimer interface [polypeptide binding]; other site
176299015436	conserved gate region; other site
176299015437	putative PBP binding loops; other site
176299015438	ABC-ATPase subunit interface; other site
176299015439	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299015440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015441	dimer interface [polypeptide binding]; other site
176299015442	conserved gate region; other site
176299015443	putative PBP binding loops; other site
176299015444	ABC-ATPase subunit interface; other site
176299015445	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
176299015446	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
176299015447	active site
176299015448	catalytic site [active]
176299015449	metal binding site [ion binding]; metal-binding site
176299015450	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299015451	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299015452	Walker A/P-loop; other site
176299015453	ATP binding site [chemical binding]; other site
176299015454	Q-loop/lid; other site
176299015455	ABC transporter signature motif; other site
176299015456	Walker B; other site
176299015457	D-loop; other site
176299015458	H-loop/switch region; other site
176299015459	TOBE domain; Region: TOBE_2; pfam08402
176299015460	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
176299015461	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
176299015462	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
176299015463	putative active site [active]
176299015464	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299015465	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
176299015466	putative DNA binding site [nucleotide binding]; other site
176299015467	putative Zn2+ binding site [ion binding]; other site
176299015468	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299015469	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299015470	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299015471	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299015472	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299015473	inhibitor site; inhibition site
176299015474	active site
176299015475	dimer interface [polypeptide binding]; other site
176299015476	catalytic residue [active]
176299015477	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299015478	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299015479	Q-loop/lid; other site
176299015480	ABC transporter signature motif; other site
176299015481	Walker B; other site
176299015482	D-loop; other site
176299015483	H-loop/switch region; other site
176299015484	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299015485	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299015486	Walker A/P-loop; other site
176299015487	ATP binding site [chemical binding]; other site
176299015488	Q-loop/lid; other site
176299015489	ABC transporter signature motif; other site
176299015490	Walker B; other site
176299015491	D-loop; other site
176299015492	H-loop/switch region; other site
176299015493	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299015494	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299015495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015496	dimer interface [polypeptide binding]; other site
176299015497	conserved gate region; other site
176299015498	putative PBP binding loops; other site
176299015499	ABC-ATPase subunit interface; other site
176299015500	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299015501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015502	dimer interface [polypeptide binding]; other site
176299015503	conserved gate region; other site
176299015504	putative PBP binding loops; other site
176299015505	ABC-ATPase subunit interface; other site
176299015506	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299015507	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_12; cd08491
176299015508	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
176299015509	BNR repeat-like domain; Region: BNR_2; pfam13088
176299015510	Pyridoxal phosphate biosynthesis protein [Coenzyme metabolism]; Region: PdxA; COG1995
176299015511	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
176299015512	active site
176299015513	NAD binding site [chemical binding]; other site
176299015514	metal binding site [ion binding]; metal-binding site
176299015515	Transcriptional regulators [Transcription]; Region: FadR; COG2186
176299015516	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299015517	DNA-binding site [nucleotide binding]; DNA binding site
176299015518	FCD domain; Region: FCD; pfam07729
176299015519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
176299015520	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
176299015521	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299015522	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299015523	DNA binding site [nucleotide binding]
176299015524	domain linker motif; other site
176299015525	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
176299015526	dimerization interface [polypeptide binding]; other site
176299015527	ligand binding site [chemical binding]; other site
176299015528	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
176299015529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015530	dimer interface [polypeptide binding]; other site
176299015531	conserved gate region; other site
176299015532	putative PBP binding loops; other site
176299015533	ABC-ATPase subunit interface; other site
176299015534	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299015535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015536	dimer interface [polypeptide binding]; other site
176299015537	conserved gate region; other site
176299015538	putative PBP binding loops; other site
176299015539	ABC-ATPase subunit interface; other site
176299015540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
176299015541	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
176299015542	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299015543	Walker A/P-loop; other site
176299015544	ATP binding site [chemical binding]; other site
176299015545	Q-loop/lid; other site
176299015546	ABC transporter signature motif; other site
176299015547	Walker B; other site
176299015548	D-loop; other site
176299015549	H-loop/switch region; other site
176299015550	TOBE domain; Region: TOBE_2; pfam08402
176299015551	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
176299015552	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015553	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
176299015554	putative substrate binding pocket [chemical binding]; other site
176299015555	putative dimerization interface [polypeptide binding]; other site
176299015556	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
176299015557	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
176299015558	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
176299015559	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
176299015560	Walker A motif; other site
176299015561	Walker A motif; other site
176299015562	ATP binding site [chemical binding]; other site
176299015563	Walker B motif; other site
176299015564	DNA repair and recombination protein RadB; Region: recomb_radB; TIGR02237
176299015565	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
176299015566	Walker A motif; other site
176299015567	ATP binding site [chemical binding]; other site
176299015568	Walker B motif; other site
176299015569	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
176299015570	HWE histidine kinase; Region: HWE_HK; pfam07536
176299015571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
176299015572	Uncharacterized conserved protein [Function unknown]; Region: COG4544
176299015573	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
176299015574	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
176299015575	DXD motif; other site
176299015576	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
176299015577	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
176299015578	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299015579	zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
176299015580	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
176299015581	Transposase; Region: DDE_Tnp_ISL3; pfam01610
176299015582	Uncharacterized conserved protein [Function unknown]; Region: COG2135
176299015583	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
176299015584	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
176299015585	active site
176299015586	DNA binding site [nucleotide binding]
176299015587	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
176299015588	DNA binding site [nucleotide binding]
176299015589	Uncharacterized conserved protein [Function unknown]; Region: COG4544
176299015590	DNA Polymerase Y-family; Region: PolY_like; cd03468
176299015591	active site
176299015592	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
176299015593	DNA binding site [nucleotide binding]
176299015594	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
176299015595	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
176299015596	putative active site [active]
176299015597	putative PHP Thumb interface [polypeptide binding]; other site
176299015598	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
176299015599	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
176299015600	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
176299015601	generic binding surface I; other site
176299015602	generic binding surface II; other site
176299015603	Protein of unknown function (DUF1419); Region: DUF1419; pfam07215
176299015604	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
176299015605	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
176299015606	Uncharacterized conserved protein [Function unknown]; Region: COG5489
176299015607	DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cd00591
176299015608	dimer interface [polypeptide binding]; other site
176299015609	DNA binding site [nucleotide binding]
176299015610	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
176299015611	Ti-type conjugative transfer system protein TraG; Region: TraG-Ti; TIGR02767
176299015612	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
176299015613	Walker A motif; other site
176299015614	ATP binding site [chemical binding]; other site
176299015615	Walker B motif; other site
176299015616	Conjugal transfer protein TraD; Region: TraD; pfam06412
176299015617	TraC-like protein; Region: TraC; pfam07820
176299015618	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
176299015619	MobA/MobL family; Region: MobA_MobL; pfam03389
176299015620	AAA domain; Region: AAA_30; pfam13604
176299015621	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402
176299015622	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
176299015623	HipA N-terminal domain; Region: Couple_hipA; cl11853
176299015624	HipA-like N-terminal domain; Region: HipA_N; pfam07805
176299015625	HipA-like C-terminal domain; Region: HipA_C; pfam07804
176299015626	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299015627	non-specific DNA binding site [nucleotide binding]; other site
176299015628	salt bridge; other site
176299015629	sequence-specific DNA binding site [nucleotide binding]; other site
176299015630	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
176299015631	active site
176299015632	NTP binding site [chemical binding]; other site
176299015633	metal binding triad [ion binding]; metal-binding site
176299015634	antibiotic binding site [chemical binding]; other site
176299015635	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
176299015636	hypothetical protein; Provisional; Region: PRK07505
176299015637	8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
176299015638	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
176299015639	catalytic residue [active]
176299015640	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299015641	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
176299015642	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299015643	DNA binding site [nucleotide binding]
176299015644	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299015645	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299015646	DNA binding site [nucleotide binding]
176299015647	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
176299015648	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299015649	NAD(P) binding site [chemical binding]; other site
176299015650	active site
176299015651	acetolactate synthase catalytic subunit; Validated; Region: PRK06112
176299015652	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
176299015653	PYR/PP interface [polypeptide binding]; other site
176299015654	dimer interface [polypeptide binding]; other site
176299015655	TPP binding site [chemical binding]; other site
176299015656	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
176299015657	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
176299015658	TPP-binding site [chemical binding]; other site
176299015659	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
176299015660	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299015661	inhibitor-cofactor binding pocket; inhibition site
176299015662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299015663	catalytic residue [active]
176299015664	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299015665	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
176299015666	DNA-binding site [nucleotide binding]; DNA binding site
176299015667	FCD domain; Region: FCD; pfam07729
176299015668	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299015669	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299015670	Walker A/P-loop; other site
176299015671	ATP binding site [chemical binding]; other site
176299015672	Q-loop/lid; other site
176299015673	ABC transporter signature motif; other site
176299015674	Walker B; other site
176299015675	D-loop; other site
176299015676	H-loop/switch region; other site
176299015677	TOBE domain; Region: TOBE_2; pfam08402
176299015678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015679	dimer interface [polypeptide binding]; other site
176299015680	conserved gate region; other site
176299015681	putative PBP binding loops; other site
176299015682	ABC-ATPase subunit interface; other site
176299015683	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299015684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015685	dimer interface [polypeptide binding]; other site
176299015686	conserved gate region; other site
176299015687	putative PBP binding loops; other site
176299015688	ABC-ATPase subunit interface; other site
176299015689	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
176299015690	2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227
176299015691	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
176299015692	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
176299015693	Walker A/P-loop; other site
176299015694	ATP binding site [chemical binding]; other site
176299015695	Q-loop/lid; other site
176299015696	ABC transporter signature motif; other site
176299015697	Walker B; other site
176299015698	D-loop; other site
176299015699	H-loop/switch region; other site
176299015700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
176299015701	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
176299015702	FtsX-like permease family; Region: FtsX; pfam02687
176299015703	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
176299015704	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
176299015705	FtsX-like permease family; Region: FtsX; pfam02687
176299015706	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
176299015707	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
176299015708	Transcriptional regulator [Transcription]; Region: IclR; COG1414
176299015709	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299015710	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
176299015711	tetramerization interface [polypeptide binding]; other site
176299015712	NAD(P) binding site [chemical binding]; other site
176299015713	catalytic residues [active]
176299015714	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
176299015715	putative active site [active]
176299015716	metal binding site [ion binding]; metal-binding site
176299015717	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
176299015718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299015719	S-adenosylmethionine binding site [chemical binding]; other site
176299015720	Cupin; Region: Cupin_6; pfam12852
176299015721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299015722	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299015723	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
176299015724	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
176299015725	trimer interface [polypeptide binding]; other site
176299015726	active site
176299015727	substrate binding site [chemical binding]; other site
176299015728	CoA binding site [chemical binding]; other site
176299015729	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
176299015730	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299015731	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
176299015732	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299015733	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299015734	Coenzyme A binding pocket [chemical binding]; other site
176299015735	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
176299015736	MgtC family; Region: MgtC; pfam02308
176299015737	OsmC-like protein; Region: OsmC; cl00767
176299015738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299015739	Coenzyme A binding pocket [chemical binding]; other site
176299015740	glutathionine S-transferase; Provisional; Region: PRK10542
176299015741	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
176299015742	C-terminal domain interface [polypeptide binding]; other site
176299015743	GSH binding site (G-site) [chemical binding]; other site
176299015744	dimer interface [polypeptide binding]; other site
176299015745	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
176299015746	dimer interface [polypeptide binding]; other site
176299015747	N-terminal domain interface [polypeptide binding]; other site
176299015748	substrate binding pocket (H-site) [chemical binding]; other site
176299015749	Predicted transcriptional regulators [Transcription]; Region: COG1733
176299015750	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299015751	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
176299015752	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
176299015753	short chain dehydrogenase; Region: adh_short; pfam00106
176299015754	NADP binding site [chemical binding]; other site
176299015755	substrate binding site [chemical binding]; other site
176299015756	active site
176299015757	Protein required for attachment to host cells [Cell motility and secretion]; Region: COG5622
176299015758	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
176299015759	Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702
176299015760	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
176299015761	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
176299015762	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
176299015763	Type IV secretory pathway, VirB6 components [Intracellular trafficking and secretion]; Region: VirB6; COG3704
176299015764	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
176299015765	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
176299015766	VirB7 interaction site; other site
176299015767	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
176299015768	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
176299015769	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
176299015770	ATP binding site [chemical binding]; other site
176299015771	Walker A motif; other site
176299015772	hexamer interface [polypeptide binding]; other site
176299015773	Walker B motif; other site
176299015774	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126
176299015775	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833
176299015776	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299015777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299015778	active site
176299015779	phosphorylation site [posttranslational modification]
176299015780	intermolecular recognition site; other site
176299015781	dimerization interface [polypeptide binding]; other site
176299015782	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299015783	DNA binding site [nucleotide binding]
176299015784	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299015785	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299015786	dimer interface [polypeptide binding]; other site
176299015787	phosphorylation site [posttranslational modification]
176299015788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299015789	ATP binding site [chemical binding]; other site
176299015790	Mg2+ binding site [ion binding]; other site
176299015791	G-X-G motif; other site
176299015792	macrolide transporter subunit MacA; Provisional; Region: PRK11578
176299015793	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
176299015794	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299015795	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
176299015796	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
176299015797	Walker A/P-loop; other site
176299015798	ATP binding site [chemical binding]; other site
176299015799	Q-loop/lid; other site
176299015800	ABC transporter signature motif; other site
176299015801	Walker B; other site
176299015802	D-loop; other site
176299015803	H-loop/switch region; other site
176299015804	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
176299015805	FtsX-like permease family; Region: FtsX; pfam02687
176299015806	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
176299015807	classical (c) SDRs; Region: SDR_c; cd05233
176299015808	NAD(P) binding site [chemical binding]; other site
176299015809	active site
176299015810	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
176299015811	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
176299015812	NAD(P) binding site [chemical binding]; other site
176299015813	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
176299015814	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
176299015815	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299015816	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015817	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299015818	putative effector binding pocket; other site
176299015819	dimerization interface [polypeptide binding]; other site
176299015820	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299015821	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
176299015822	NAD(P) binding site [chemical binding]; other site
176299015823	active site
176299015824	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299015825	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015826	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299015827	putative effector binding pocket; other site
176299015828	dimerization interface [polypeptide binding]; other site
176299015829	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
176299015830	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
176299015831	putative NAD(P) binding site [chemical binding]; other site
176299015832	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
176299015833	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299015834	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299015835	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
176299015836	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
176299015837	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
176299015838	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
176299015839	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
176299015840	DNA binding residues [nucleotide binding]
176299015841	dimer interface [polypeptide binding]; other site
176299015842	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299015843	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015844	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299015845	putative effector binding pocket; other site
176299015846	dimerization interface [polypeptide binding]; other site
176299015847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
176299015848	Trehalase; Region: Trehalase; cl17346
176299015849	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
176299015850	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299015851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015852	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
176299015853	substrate binding pocket [chemical binding]; other site
176299015854	dimerization interface [polypeptide binding]; other site
176299015855	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
176299015856	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
176299015857	active site
176299015858	catalytic tetrad [active]
176299015859	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299015860	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130
176299015861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299015862	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299015863	putative substrate translocation pore; other site
176299015864	Pirin-related protein [General function prediction only]; Region: COG1741
176299015865	Pirin; Region: Pirin; pfam02678
176299015866	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
176299015867	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
176299015868	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
176299015869	catalytic Zn binding site [ion binding]; other site
176299015870	NAD binding site [chemical binding]; other site
176299015871	structural Zn binding site [ion binding]; other site
176299015872	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
176299015873	Pseudomonas putida aldehyde dehydrogenase PsfA (ACA09737)-like; Region: ALDH_PsfA-ACA09737; cd07120
176299015874	NAD(P) binding site [chemical binding]; other site
176299015875	catalytic residues [active]
176299015876	LysR family transcriptional regulator; Provisional; Region: PRK14997
176299015877	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015878	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299015879	putative effector binding pocket; other site
176299015880	dimerization interface [polypeptide binding]; other site
176299015881	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
176299015882	dimer interface [polypeptide binding]; other site
176299015883	FMN binding site [chemical binding]; other site
176299015884	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299015885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015886	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
176299015887	putative effector binding pocket; other site
176299015888	putative dimerization interface [polypeptide binding]; other site
176299015889	SnoaL-like domain; Region: SnoaL_2; pfam12680
176299015890	short chain dehydrogenase; Provisional; Region: PRK06523
176299015891	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299015892	NAD(P) binding site [chemical binding]; other site
176299015893	active site
176299015894	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299015895	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
176299015896	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299015897	Serine hydrolase; Region: Ser_hydrolase; cl17834
176299015898	2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292
176299015899	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
176299015900	putative NAD(P) binding site [chemical binding]; other site
176299015901	putative dimer interface [polypeptide binding]; other site
176299015902	short chain dehydrogenase; Provisional; Region: PRK06500
176299015903	classical (c) SDRs; Region: SDR_c; cd05233
176299015904	NAD(P) binding site [chemical binding]; other site
176299015905	active site
176299015906	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299015907	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299015908	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
176299015909	putative effector binding pocket; other site
176299015910	putative dimerization interface [polypeptide binding]; other site
176299015911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299015912	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
176299015913	Walker A/P-loop; other site
176299015914	ATP binding site [chemical binding]; other site
176299015915	Q-loop/lid; other site
176299015916	ABC transporter signature motif; other site
176299015917	Walker B; other site
176299015918	D-loop; other site
176299015919	H-loop/switch region; other site
176299015920	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
176299015921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015922	dimer interface [polypeptide binding]; other site
176299015923	conserved gate region; other site
176299015924	putative PBP binding loops; other site
176299015925	ABC-ATPase subunit interface; other site
176299015926	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
176299015927	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299015928	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
176299015929	putative ligand binding site [chemical binding]; other site
176299015930	NAD binding site [chemical binding]; other site
176299015931	dimerization interface [polypeptide binding]; other site
176299015932	catalytic site [active]
176299015933	Amino acid synthesis; Region: AA_synth; pfam06684
176299015934	NIPSNAP; Region: NIPSNAP; pfam07978
176299015935	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
176299015936	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
176299015937	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299015938	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
176299015939	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
176299015940	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
176299015941	NAD(P) binding site [chemical binding]; other site
176299015942	catalytic residues [active]
176299015943	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
176299015944	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
176299015945	nudix motif; other site
176299015946	GAF domain; Region: GAF_2; pfam13185
176299015947	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
176299015948	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
176299015949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
176299015950	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
176299015951	homotrimer interaction site [polypeptide binding]; other site
176299015952	putative active site [active]
176299015953	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
176299015954	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
176299015955	dimer interface [polypeptide binding]; other site
176299015956	active site
176299015957	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
176299015958	substrate binding site [chemical binding]; other site
176299015959	catalytic residue [active]
176299015960	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299015961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015962	dimer interface [polypeptide binding]; other site
176299015963	conserved gate region; other site
176299015964	putative PBP binding loops; other site
176299015965	ABC-ATPase subunit interface; other site
176299015966	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299015967	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299015968	dimer interface [polypeptide binding]; other site
176299015969	conserved gate region; other site
176299015970	putative PBP binding loops; other site
176299015971	ABC-ATPase subunit interface; other site
176299015972	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299015973	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299015974	Walker A/P-loop; other site
176299015975	ATP binding site [chemical binding]; other site
176299015976	Q-loop/lid; other site
176299015977	ABC transporter signature motif; other site
176299015978	Walker B; other site
176299015979	D-loop; other site
176299015980	H-loop/switch region; other site
176299015981	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299015982	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299015983	substrate binding pocket [chemical binding]; other site
176299015984	membrane-bound complex binding site; other site
176299015985	hinge residues; other site
176299015986	Predicted deacylase [General function prediction only]; Region: COG3608
176299015987	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
176299015988	active site
176299015989	Zn binding site [ion binding]; other site
176299015990	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299015991	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299015992	DNA binding site [nucleotide binding]
176299015993	domain linker motif; other site
176299015994	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
176299015995	putative dimerization interface [polypeptide binding]; other site
176299015996	putative ligand binding site [chemical binding]; other site
176299015997	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
176299015998	Cinnamyl alcohol dehydrogenases (CAD) and related proteins; Region: CAD; cd08245
176299015999	NAD binding site [chemical binding]; other site
176299016000	substrate binding site [chemical binding]; other site
176299016001	catalytic Zn binding site [ion binding]; other site
176299016002	structural Zn binding site [ion binding]; other site
176299016003	tetramer interface [polypeptide binding]; other site
176299016004	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299016005	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016006	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
176299016007	putative effector binding pocket; other site
176299016008	putative dimerization interface [polypeptide binding]; other site
176299016009	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
176299016010	homodimer interface [polypeptide binding]; other site
176299016011	homotetramer interface [polypeptide binding]; other site
176299016012	active site pocket [active]
176299016013	cleavage site
176299016014	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
176299016015	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
176299016016	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
176299016017	Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808
176299016018	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
176299016019	catalytic triad [active]
176299016020	conserved cis-peptide bond; other site
176299016021	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299016022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016023	dimer interface [polypeptide binding]; other site
176299016024	conserved gate region; other site
176299016025	putative PBP binding loops; other site
176299016026	ABC-ATPase subunit interface; other site
176299016027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016028	dimer interface [polypeptide binding]; other site
176299016029	conserved gate region; other site
176299016030	putative PBP binding loops; other site
176299016031	ABC-ATPase subunit interface; other site
176299016032	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299016033	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299016034	Walker A/P-loop; other site
176299016035	ATP binding site [chemical binding]; other site
176299016036	Q-loop/lid; other site
176299016037	ABC transporter signature motif; other site
176299016038	Walker B; other site
176299016039	D-loop; other site
176299016040	H-loop/switch region; other site
176299016041	TOBE domain; Region: TOBE_2; pfam08402
176299016042	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
176299016043	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299016044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299016045	NAD(P) binding site [chemical binding]; other site
176299016046	active site
176299016047	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299016048	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299016049	inhibitor-cofactor binding pocket; inhibition site
176299016050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299016051	catalytic residue [active]
176299016052	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
176299016053	active site
176299016054	substrate binding site [chemical binding]; other site
176299016055	Phosphotransferase enzyme family; Region: APH; pfam01636
176299016056	ATP binding site [chemical binding]; other site
176299016057	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299016058	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
176299016059	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299016060	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016061	dimer interface [polypeptide binding]; other site
176299016062	conserved gate region; other site
176299016063	putative PBP binding loops; other site
176299016064	ABC-ATPase subunit interface; other site
176299016065	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299016066	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299016067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016068	dimer interface [polypeptide binding]; other site
176299016069	conserved gate region; other site
176299016070	putative PBP binding loops; other site
176299016071	ABC-ATPase subunit interface; other site
176299016072	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
176299016073	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299016074	Walker A/P-loop; other site
176299016075	ATP binding site [chemical binding]; other site
176299016076	Q-loop/lid; other site
176299016077	ABC transporter signature motif; other site
176299016078	Walker B; other site
176299016079	D-loop; other site
176299016080	H-loop/switch region; other site
176299016081	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299016082	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
176299016083	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299016084	Walker A/P-loop; other site
176299016085	ATP binding site [chemical binding]; other site
176299016086	Q-loop/lid; other site
176299016087	ABC transporter signature motif; other site
176299016088	Walker B; other site
176299016089	D-loop; other site
176299016090	H-loop/switch region; other site
176299016091	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299016092	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
176299016093	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299016094	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016095	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
176299016096	substrate binding pocket [chemical binding]; other site
176299016097	dimerization interface [polypeptide binding]; other site
176299016098	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
176299016099	Tannase and feruloyl esterase; Region: Tannase; pfam07519
176299016100	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299016101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016102	dimer interface [polypeptide binding]; other site
176299016103	conserved gate region; other site
176299016104	putative PBP binding loops; other site
176299016105	ABC-ATPase subunit interface; other site
176299016106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016107	dimer interface [polypeptide binding]; other site
176299016108	putative PBP binding loops; other site
176299016109	ABC-ATPase subunit interface; other site
176299016110	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299016111	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299016112	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
176299016113	Cache domain; Region: Cache_2; pfam08269
176299016114	Histidine kinase; Region: HisKA_3; pfam07730
176299016115	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299016116	ATP binding site [chemical binding]; other site
176299016117	Mg2+ binding site [ion binding]; other site
176299016118	G-X-G motif; other site
176299016119	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
176299016120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299016121	active site
176299016122	phosphorylation site [posttranslational modification]
176299016123	intermolecular recognition site; other site
176299016124	dimerization interface [polypeptide binding]; other site
176299016125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299016126	DNA binding residues [nucleotide binding]
176299016127	dimerization interface [polypeptide binding]; other site
176299016128	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
176299016129	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
176299016130	DctM-like transporters; Region: DctM; pfam06808
176299016131	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
176299016132	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
176299016133	Predicted transcriptional regulator [Transcription]; Region: COG2378
176299016134	HTH domain; Region: HTH_11; pfam08279
176299016135	WYL domain; Region: WYL; pfam13280
176299016136	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
176299016137	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
176299016138	putative C-terminal domain interface [polypeptide binding]; other site
176299016139	putative GSH binding site (G-site) [chemical binding]; other site
176299016140	putative dimer interface [polypeptide binding]; other site
176299016141	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
176299016142	dimer interface [polypeptide binding]; other site
176299016143	N-terminal domain interface [polypeptide binding]; other site
176299016144	putative substrate binding pocket (H-site) [chemical binding]; other site
176299016145	Transcriptional regulators [Transcription]; Region: MarR; COG1846
176299016146	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
176299016147	putative DNA binding site [nucleotide binding]; other site
176299016148	putative Zn2+ binding site [ion binding]; other site
176299016149	Cupin; Region: Cupin_6; pfam12852
176299016150	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299016151	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
176299016152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299016153	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
176299016154	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
176299016155	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
176299016156	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
176299016157	NAD binding site [chemical binding]; other site
176299016158	metal binding site [ion binding]; metal-binding site
176299016159	active site
176299016160	Predicted small integral membrane protein [Function unknown]; Region: COG5478
176299016161	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
176299016162	dimerization interface [polypeptide binding]; other site
176299016163	metal binding site [ion binding]; metal-binding site
176299016164	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
176299016165	catalytic triad [active]
176299016166	conserved cis-peptide bond; other site
176299016167	RNA polymerase sigma factor; Provisional; Region: PRK12540
176299016168	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
176299016169	DNA binding residues [nucleotide binding]
176299016170	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
176299016171	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
176299016172	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
176299016173	catalytic site [active]
176299016174	active site
176299016175	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
176299016176	glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095
176299016177	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
176299016178	ADP-binding pocket [chemical binding]; other site
176299016179	homodimer interface [polypeptide binding]; other site
176299016180	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
176299016181	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299016182	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
176299016183	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
176299016184	putative NAD(P) binding site [chemical binding]; other site
176299016185	active site
176299016186	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299016187	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299016188	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
176299016189	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
176299016190	hypothetical protein; Provisional; Region: PRK13559
176299016191	Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083
176299016192	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299016193	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299016194	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299016195	Uncharacterized conserved protein [Function unknown]; Region: COG5397
176299016196	PIN domain; Region: PIN_3; pfam13470
176299016197	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
176299016198	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
176299016199	inhibitor-cofactor binding pocket; inhibition site
176299016200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299016201	catalytic residue [active]
176299016202	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016203	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
176299016204	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299016205	dimerization interface [polypeptide binding]; other site
176299016206	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
176299016207	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
176299016208	dimer interface [polypeptide binding]; other site
176299016209	active site
176299016210	citrylCoA binding site [chemical binding]; other site
176299016211	oxalacetate/citrate binding site [chemical binding]; other site
176299016212	coenzyme A binding site [chemical binding]; other site
176299016213	catalytic triad [active]
176299016214	Helix-turn-helix domain; Region: HTH_17; pfam12728
176299016215	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
176299016216	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102
176299016217	dimer interface [polypeptide binding]; other site
176299016218	active site
176299016219	coenzyme A binding site [chemical binding]; other site
176299016220	citrylCoA binding site [chemical binding]; other site
176299016221	oxalacetate/citrate binding site [chemical binding]; other site
176299016222	catalytic triad [active]
176299016223	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
176299016224	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299016225	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
176299016226	DNA binding residues [nucleotide binding]
176299016227	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
176299016228	FecR protein; Region: FecR; pfam04773
176299016229	Secretin and TonB N terminus short domain; Region: STN; smart00965
176299016230	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
176299016231	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
176299016232	N-terminal plug; other site
176299016233	ligand-binding site [chemical binding]; other site
176299016234	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
176299016235	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
176299016236	siderophore binding site; other site
176299016237	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
176299016238	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
176299016239	FAD binding pocket [chemical binding]; other site
176299016240	FAD binding motif [chemical binding]; other site
176299016241	phosphate binding motif [ion binding]; other site
176299016242	NAD binding pocket [chemical binding]; other site
176299016243	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299016244	ABC-ATPase subunit  interface; other site
176299016245	dimer interface [polypeptide binding]; other site
176299016246	putative PBP binding regions; other site
176299016247	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
176299016248	ABC-ATPase subunit  interface; other site
176299016249	dimer interface [polypeptide binding]; other site
176299016250	putative PBP binding regions; other site
176299016251	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
176299016252	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
176299016253	Walker A/P-loop; other site
176299016254	ATP binding site [chemical binding]; other site
176299016255	Q-loop/lid; other site
176299016256	ABC transporter signature motif; other site
176299016257	Walker B; other site
176299016258	D-loop; other site
176299016259	H-loop/switch region; other site
176299016260	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
176299016261	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299016262	dimerization interface [polypeptide binding]; other site
176299016263	putative DNA binding site [nucleotide binding]; other site
176299016264	putative Zn2+ binding site [ion binding]; other site
176299016265	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
176299016266	Major Facilitator Superfamily; Region: MFS_1; pfam07690
176299016267	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299016268	putative substrate translocation pore; other site
176299016269	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
176299016270	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
176299016271	putative NAD(P) binding site [chemical binding]; other site
176299016272	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299016273	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016274	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299016275	putative effector binding pocket; other site
176299016276	dimerization interface [polypeptide binding]; other site
176299016277	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299016278	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016279	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299016280	dimerization interface [polypeptide binding]; other site
176299016281	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299016282	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
176299016283	ligand binding site [chemical binding]; other site
176299016284	NAD binding site [chemical binding]; other site
176299016285	dimerization interface [polypeptide binding]; other site
176299016286	catalytic site [active]
176299016287	hypothetical protein; Validated; Region: PRK06201
176299016288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
176299016289	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299016290	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
176299016291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
176299016292	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
176299016293	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
176299016294	putative ligand binding site [chemical binding]; other site
176299016295	putative NAD binding site [chemical binding]; other site
176299016296	catalytic site [active]
176299016297	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
176299016298	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
176299016299	MOFRL family; Region: MOFRL; pfam05161
176299016300	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
176299016301	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
176299016302	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
176299016303	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299016304	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
176299016305	EamA-like transporter family; Region: EamA; pfam00892
176299016306	EamA-like transporter family; Region: EamA; pfam00892
176299016307	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
176299016308	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
176299016309	conserved cys residue [active]
176299016310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299016311	Uncharacterized conserved protein [Function unknown]; Region: COG3246
176299016312	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299016313	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
176299016314	bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531
176299016315	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
176299016316	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
176299016317	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
176299016318	active site
176299016319	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299016320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016321	dimer interface [polypeptide binding]; other site
176299016322	conserved gate region; other site
176299016323	putative PBP binding loops; other site
176299016324	ABC-ATPase subunit interface; other site
176299016325	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
176299016326	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
176299016327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016328	dimer interface [polypeptide binding]; other site
176299016329	conserved gate region; other site
176299016330	putative PBP binding loops; other site
176299016331	ABC-ATPase subunit interface; other site
176299016332	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299016333	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299016334	Walker A/P-loop; other site
176299016335	ATP binding site [chemical binding]; other site
176299016336	Q-loop/lid; other site
176299016337	ABC transporter signature motif; other site
176299016338	Walker B; other site
176299016339	D-loop; other site
176299016340	H-loop/switch region; other site
176299016341	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299016342	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299016343	Walker A/P-loop; other site
176299016344	ATP binding site [chemical binding]; other site
176299016345	Q-loop/lid; other site
176299016346	ABC transporter signature motif; other site
176299016347	Walker B; other site
176299016348	D-loop; other site
176299016349	H-loop/switch region; other site
176299016350	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299016351	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299016352	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
176299016353	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299016354	PAS fold; Region: PAS_3; pfam08447
176299016355	putative active site [active]
176299016356	heme pocket [chemical binding]; other site
176299016357	Fic family protein [Function unknown]; Region: COG3177
176299016358	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
176299016359	Fic/DOC family; Region: Fic; pfam02661
176299016360	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
176299016361	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
176299016362	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299016363	Helix-turn-helix domain; Region: HTH_28; pfam13518
176299016364	putative transposase OrfB; Reviewed; Region: PHA02517
176299016365	HTH-like domain; Region: HTH_21; pfam13276
176299016366	Integrase core domain; Region: rve; pfam00665
176299016367	Integrase core domain; Region: rve_2; pfam13333
176299016368	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
176299016369	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
176299016370	Autotransporter beta-domain; Region: Autotransporter; smart00869
176299016371	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
176299016372	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
176299016373	Uncharacterized conserved protein [Function unknown]; Region: COG3422
176299016374	aquaporin Z; Provisional; Region: PRK05420
176299016375	amphipathic channel; other site
176299016376	Asn-Pro-Ala signature motifs; other site
176299016377	Protein of unknown function (DUF2865); Region: DUF2865; pfam11064
176299016378	Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991
176299016379	Bacterial SH3 domain; Region: SH3_3; pfam08239
176299016380	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
176299016381	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
176299016382	Autotransporter beta-domain; Region: Autotransporter; smart00869
176299016383	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
176299016384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299016385	Transposase; Region: HTH_Tnp_1; cl17663
176299016386	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
176299016387	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
176299016388	putative transposase OrfB; Reviewed; Region: PHA02517
176299016389	HTH-like domain; Region: HTH_21; pfam13276
176299016390	Integrase core domain; Region: rve; pfam00665
176299016391	Integrase core domain; Region: rve_3; pfam13683
176299016392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299016393	Transposase; Region: HTH_Tnp_1; cl17663
176299016394	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
176299016395	metal binding site [ion binding]; metal-binding site
176299016396	active site
176299016397	I-site; other site
176299016398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299016399	hypothetical protein; Provisional; Region: PRK13559
176299016400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299016401	putative active site [active]
176299016402	heme pocket [chemical binding]; other site
176299016403	HWE histidine kinase; Region: HWE_HK; cl06527
176299016404	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299016405	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299016406	putative active site [active]
176299016407	heme pocket [chemical binding]; other site
176299016408	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299016409	putative active site [active]
176299016410	heme pocket [chemical binding]; other site
176299016411	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
176299016412	Histidine kinase; Region: HisKA_2; pfam07568
176299016413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299016414	ATP binding site [chemical binding]; other site
176299016415	Mg2+ binding site [ion binding]; other site
176299016416	G-X-G motif; other site
176299016417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299016418	active site
176299016419	phosphorylation site [posttranslational modification]
176299016420	intermolecular recognition site; other site
176299016421	dimerization interface [polypeptide binding]; other site
176299016422	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
176299016423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
176299016424	Coenzyme A binding pocket [chemical binding]; other site
176299016425	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
176299016426	MMPL family; Region: MMPL; cl14618
176299016427	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
176299016428	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299016429	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299016430	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299016431	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299016432	Fic family protein [Function unknown]; Region: COG3177
176299016433	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
176299016434	Fic/DOC family; Region: Fic; pfam02661
176299016435	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
176299016436	putative DNA binding site [nucleotide binding]; other site
176299016437	putative Zn2+ binding site [ion binding]; other site
176299016438	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299016439	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299016440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
176299016441	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299016442	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299016443	Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
176299016444	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
176299016445	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
176299016446	conserved cys residue [active]
176299016447	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299016448	short chain dehydrogenase; Provisional; Region: PRK06500
176299016449	classical (c) SDRs; Region: SDR_c; cd05233
176299016450	NAD(P) binding site [chemical binding]; other site
176299016451	active site
176299016452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299016453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016454	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
176299016455	putative effector binding pocket; other site
176299016456	dimerization interface [polypeptide binding]; other site
176299016457	Transcriptional regulators [Transcription]; Region: PurR; COG1609
176299016458	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299016459	DNA binding site [nucleotide binding]
176299016460	domain linker motif; other site
176299016461	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
176299016462	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299016463	inhibitor site; inhibition site
176299016464	active site
176299016465	dimer interface [polypeptide binding]; other site
176299016466	catalytic residue [active]
176299016467	benzoate transport; Region: 2A0115; TIGR00895
176299016468	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
176299016469	putative substrate translocation pore; other site
176299016470	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299016471	inhibitor site; inhibition site
176299016472	active site
176299016473	dimer interface [polypeptide binding]; other site
176299016474	catalytic residue [active]
176299016475	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
176299016476	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299016477	putative ligand binding site [chemical binding]; other site
176299016478	putative NAD binding site [chemical binding]; other site
176299016479	catalytic site [active]
176299016480	spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187
176299016481	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299016482	Q-loop/lid; other site
176299016483	ABC transporter signature motif; other site
176299016484	Walker B; other site
176299016485	D-loop; other site
176299016486	H-loop/switch region; other site
176299016487	TOBE domain; Region: TOBE_2; pfam08402
176299016488	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299016489	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016490	dimer interface [polypeptide binding]; other site
176299016491	conserved gate region; other site
176299016492	putative PBP binding loops; other site
176299016493	ABC-ATPase subunit interface; other site
176299016494	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
176299016495	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299016496	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
176299016497	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299016498	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
176299016499	DNA-binding site [nucleotide binding]; DNA binding site
176299016500	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
176299016501	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299016502	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299016503	DNA-binding site [nucleotide binding]; DNA binding site
176299016504	FCD domain; Region: FCD; pfam07729
176299016505	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299016506	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299016507	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299016508	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016509	dimer interface [polypeptide binding]; other site
176299016510	conserved gate region; other site
176299016511	putative PBP binding loops; other site
176299016512	ABC-ATPase subunit interface; other site
176299016513	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299016514	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299016515	substrate binding pocket [chemical binding]; other site
176299016516	membrane-bound complex binding site; other site
176299016517	hinge residues; other site
176299016518	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299016519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299016520	Walker A/P-loop; other site
176299016521	ATP binding site [chemical binding]; other site
176299016522	Q-loop/lid; other site
176299016523	ABC transporter signature motif; other site
176299016524	Walker B; other site
176299016525	D-loop; other site
176299016526	H-loop/switch region; other site
176299016527	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
176299016528	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299016529	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016530	dimer interface [polypeptide binding]; other site
176299016531	conserved gate region; other site
176299016532	putative PBP binding loops; other site
176299016533	ABC-ATPase subunit interface; other site
176299016534	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299016535	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016536	dimer interface [polypeptide binding]; other site
176299016537	conserved gate region; other site
176299016538	putative PBP binding loops; other site
176299016539	ABC-ATPase subunit interface; other site
176299016540	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
176299016541	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299016542	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
176299016543	active site
176299016544	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
176299016545	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
176299016546	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
176299016547	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299016548	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016549	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299016550	dimerization interface [polypeptide binding]; other site
176299016551	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
176299016552	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299016553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
176299016554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016555	ABC-ATPase subunit interface; other site
176299016556	putative PBP binding loops; other site
176299016557	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299016558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016559	dimer interface [polypeptide binding]; other site
176299016560	conserved gate region; other site
176299016561	putative PBP binding loops; other site
176299016562	ABC-ATPase subunit interface; other site
176299016563	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
176299016564	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
176299016565	Walker A/P-loop; other site
176299016566	ATP binding site [chemical binding]; other site
176299016567	Q-loop/lid; other site
176299016568	ABC transporter signature motif; other site
176299016569	Walker B; other site
176299016570	D-loop; other site
176299016571	H-loop/switch region; other site
176299016572	TOBE domain; Region: TOBE_2; pfam08402
176299016573	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
176299016574	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
176299016575	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
176299016576	putative catalytic residue [active]
176299016577	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950
176299016578	Uncharacterized conserved protein [Function unknown]; Region: COG2128
176299016579	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
176299016580	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
176299016581	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
176299016582	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299016583	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299016584	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
176299016585	DNA binding site [nucleotide binding]
176299016586	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
176299016587	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299016588	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299016589	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
176299016590	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
176299016591	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
176299016592	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299016593	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299016594	Predicted transcriptional regulators [Transcription]; Region: COG1733
176299016595	dimerization interface [polypeptide binding]; other site
176299016596	putative DNA binding site [nucleotide binding]; other site
176299016597	putative Zn2+ binding site [ion binding]; other site
176299016598	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299016599	classical (c) SDRs; Region: SDR_c; cd05233
176299016600	NAD(P) binding site [chemical binding]; other site
176299016601	active site
176299016602	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
176299016603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514
176299016604	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299016605	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
176299016606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
176299016607	dimerization interface [polypeptide binding]; other site
176299016608	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299016609	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299016610	dimer interface [polypeptide binding]; other site
176299016611	putative CheW interface [polypeptide binding]; other site
176299016612	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299016613	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299016614	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
176299016615	classical (c) SDRs; Region: SDR_c; cd05233
176299016616	NAD(P) binding site [chemical binding]; other site
176299016617	active site
176299016618	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
176299016619	FMN binding site [chemical binding]; other site
176299016620	active site
176299016621	substrate binding site [chemical binding]; other site
176299016622	catalytic residue [active]
176299016623	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299016624	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
176299016625	TAP-like protein; Region: Abhydrolase_4; pfam08386
176299016626	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
176299016627	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
176299016628	putative NAD(P) binding site [chemical binding]; other site
176299016629	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
176299016630	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
176299016631	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
176299016632	putative dimer interface [polypeptide binding]; other site
176299016633	Protein of unknown function (DUF982); Region: DUF982; pfam06169
176299016634	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
176299016635	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
176299016636	Walker A/P-loop; other site
176299016637	ATP binding site [chemical binding]; other site
176299016638	Q-loop/lid; other site
176299016639	ABC transporter signature motif; other site
176299016640	Walker B; other site
176299016641	D-loop; other site
176299016642	H-loop/switch region; other site
176299016643	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
176299016644	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
176299016645	FtsX-like permease family; Region: FtsX; pfam02687
176299016646	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
176299016647	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
176299016648	FtsX-like permease family; Region: FtsX; pfam02687
176299016649	Predicted secreted hydrolase [General function prediction only]; Region: COG5621
176299016650	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502
176299016651	active site
176299016652	catalytic triad [active]
176299016653	oxyanion hole [active]
176299016654	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
176299016655	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
176299016656	inhibitor site; inhibition site
176299016657	active site
176299016658	dimer interface [polypeptide binding]; other site
176299016659	catalytic residue [active]
176299016660	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
176299016661	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299016662	active site pocket [active]
176299016663	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
176299016664	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
176299016665	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
176299016666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016667	dimer interface [polypeptide binding]; other site
176299016668	conserved gate region; other site
176299016669	putative PBP binding loops; other site
176299016670	ABC-ATPase subunit interface; other site
176299016671	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
176299016672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016673	dimer interface [polypeptide binding]; other site
176299016674	conserved gate region; other site
176299016675	putative PBP binding loops; other site
176299016676	ABC-ATPase subunit interface; other site
176299016677	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
176299016678	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
176299016679	Walker A/P-loop; other site
176299016680	ATP binding site [chemical binding]; other site
176299016681	Q-loop/lid; other site
176299016682	ABC transporter signature motif; other site
176299016683	Walker B; other site
176299016684	D-loop; other site
176299016685	H-loop/switch region; other site
176299016686	TOBE domain; Region: TOBE_2; pfam08402
176299016687	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
176299016688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299016689	NAD(P) binding site [chemical binding]; other site
176299016690	active site
176299016691	Transcriptional regulator [Transcription]; Region: IclR; COG1414
176299016692	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
176299016693	Bacterial transcriptional regulator; Region: IclR; pfam01614
176299016694	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
176299016695	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
176299016696	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299016697	classical (c) SDRs; Region: SDR_c; cd05233
176299016698	NAD(P) binding site [chemical binding]; other site
176299016699	active site
176299016700	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
176299016701	Amino acid permease; Region: AA_permease_2; pfam13520
176299016702	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
176299016703	active site
176299016704	DNA polymerase IV; Validated; Region: PRK02406
176299016705	DNA binding site [nucleotide binding]
176299016706	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
176299016707	homodimer interface [polypeptide binding]; other site
176299016708	substrate-cofactor binding pocket; other site
176299016709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
176299016710	catalytic residue [active]
176299016711	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
176299016712	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
176299016713	putative ligand binding site [chemical binding]; other site
176299016714	NAD binding site [chemical binding]; other site
176299016715	dimerization interface [polypeptide binding]; other site
176299016716	catalytic site [active]
176299016717	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
176299016718	putative metal binding site [ion binding]; other site
176299016719	hypothetical protein; Validated; Region: PRK06186
176299016720	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
176299016721	active site
176299016722	putative oxyanion hole; other site
176299016723	catalytic triad [active]
176299016724	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
176299016725	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
176299016726	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
176299016727	active site
176299016728	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
176299016729	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
176299016730	metal binding site [ion binding]; metal-binding site
176299016731	substrate binding pocket [chemical binding]; other site
176299016732	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
176299016733	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
176299016734	metal binding site [ion binding]; metal-binding site
176299016735	dimer interface [polypeptide binding]; other site
176299016736	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
176299016737	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299016738	Walker A/P-loop; other site
176299016739	ATP binding site [chemical binding]; other site
176299016740	Q-loop/lid; other site
176299016741	ABC transporter signature motif; other site
176299016742	Walker B; other site
176299016743	D-loop; other site
176299016744	H-loop/switch region; other site
176299016745	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765
176299016746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299016747	dimer interface [polypeptide binding]; other site
176299016748	conserved gate region; other site
176299016749	putative PBP binding loops; other site
176299016750	ABC-ATPase subunit interface; other site
176299016751	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299016752	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
176299016753	substrate binding pocket [chemical binding]; other site
176299016754	membrane-bound complex binding site; other site
176299016755	hinge residues; other site
176299016756	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
176299016757	DNA-binding site [nucleotide binding]; DNA binding site
176299016758	Transcriptional regulators [Transcription]; Region: GntR; COG1802
176299016759	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
176299016760	DNA-binding site [nucleotide binding]; DNA binding site
176299016761	FCD domain; Region: FCD; pfam07729
176299016762	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299016763	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
176299016764	ligand binding site [chemical binding]; other site
176299016765	flexible hinge region; other site
176299016766	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
176299016767	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
176299016768	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
176299016769	ligand binding site [chemical binding]; other site
176299016770	flexible hinge region; other site
176299016771	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
176299016772	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
176299016773	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
176299016774	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
176299016775	DNA binding residues [nucleotide binding]
176299016776	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
176299016777	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
176299016778	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
176299016779	heme binding pocket [chemical binding]; other site
176299016780	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
176299016781	domain interactions; other site
176299016782	glutamate dehydrogenase 2; Provisional; Region: PTZ00324
176299016783	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
176299016784	dimerization interface [polypeptide binding]; other site
176299016785	metal binding site [ion binding]; metal-binding site
176299016786	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
176299016787	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299016788	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
176299016789	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
176299016790	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
176299016791	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
176299016792	XdhC Rossmann domain; Region: XdhC_C; pfam13478
176299016793	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
176299016794	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
176299016795	catalytic loop [active]
176299016796	iron binding site [ion binding]; other site
176299016797	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
176299016798	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
176299016799	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
176299016800	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
176299016801	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
176299016802	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
176299016803	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
176299016804	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
176299016805	Ligand binding site; other site
176299016806	metal-binding site
176299016807	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
176299016808	conserved cys residue [active]
176299016809	Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245
176299016810	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
176299016811	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
176299016812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299016813	active site
176299016814	phosphorylation site [posttranslational modification]
176299016815	intermolecular recognition site; other site
176299016816	dimerization interface [polypeptide binding]; other site
176299016817	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299016818	DNA binding site [nucleotide binding]
176299016819	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
176299016820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299016821	ATP binding site [chemical binding]; other site
176299016822	Mg2+ binding site [ion binding]; other site
176299016823	G-X-G motif; other site
176299016824	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
176299016825	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
176299016826	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299016827	PAS fold; Region: PAS_3; pfam08447
176299016828	putative active site [active]
176299016829	heme pocket [chemical binding]; other site
176299016830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299016831	dimer interface [polypeptide binding]; other site
176299016832	phosphorylation site [posttranslational modification]
176299016833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299016834	ATP binding site [chemical binding]; other site
176299016835	Mg2+ binding site [ion binding]; other site
176299016836	G-X-G motif; other site
176299016837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299016838	active site
176299016839	phosphorylation site [posttranslational modification]
176299016840	intermolecular recognition site; other site
176299016841	dimerization interface [polypeptide binding]; other site
176299016842	circadian clock protein KaiC; Reviewed; Region: PRK09302
176299016843	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
176299016844	Walker A motif; other site
176299016845	ATP binding site [chemical binding]; other site
176299016846	Walker B motif; other site
176299016847	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
176299016848	Walker A motif; other site
176299016849	ATP binding site [chemical binding]; other site
176299016850	Walker B motif; other site
176299016851	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
176299016852	DNA-binding site [nucleotide binding]; DNA binding site
176299016853	RNA-binding motif; other site
176299016854	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
176299016855	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
176299016856	HSP70 interaction site [polypeptide binding]; other site
176299016857	EamA-like transporter family; Region: EamA; cl17759
176299016858	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
176299016859	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
176299016860	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
176299016861	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
176299016862	Flavin binding site [chemical binding]; other site
176299016863	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
176299016864	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
176299016865	Walker A/P-loop; other site
176299016866	ATP binding site [chemical binding]; other site
176299016867	Q-loop/lid; other site
176299016868	ABC transporter signature motif; other site
176299016869	Walker B; other site
176299016870	D-loop; other site
176299016871	H-loop/switch region; other site
176299016872	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
176299016873	putative ligand binding site [chemical binding]; other site
176299016874	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
176299016875	TM-ABC transporter signature motif; other site
176299016876	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299016877	TM-ABC transporter signature motif; other site
176299016878	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
176299016879	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
176299016880	Walker A/P-loop; other site
176299016881	ATP binding site [chemical binding]; other site
176299016882	Q-loop/lid; other site
176299016883	ABC transporter signature motif; other site
176299016884	Walker B; other site
176299016885	D-loop; other site
176299016886	H-loop/switch region; other site
176299016887	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
176299016888	active site
176299016889	dimer interface [polypeptide binding]; other site
176299016890	non-prolyl cis peptide bond; other site
176299016891	insertion regions; other site
176299016892	FMN reductase, MsuE subfamily; Region: FMN_reduc_MsuE; TIGR03566
176299016893	PAS fold; Region: PAS_4; pfam08448
176299016894	PAS domain S-box; Region: sensory_box; TIGR00229
176299016895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299016896	putative active site [active]
176299016897	heme pocket [chemical binding]; other site
176299016898	PAS domain S-box; Region: sensory_box; TIGR00229
176299016899	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299016900	putative active site [active]
176299016901	heme pocket [chemical binding]; other site
176299016902	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
176299016903	HWE histidine kinase; Region: HWE_HK; pfam07536
176299016904	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
176299016905	Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357
176299016906	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
176299016907	ligand binding site [chemical binding]; other site
176299016908	regulator interaction site; other site
176299016909	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
176299016910	ANTAR domain; Region: ANTAR; pfam03861
176299016911	Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331
176299016912	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
176299016913	ligand binding site [chemical binding]; other site
176299016914	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
176299016915	TM-ABC transporter signature motif; other site
176299016916	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
176299016917	TM-ABC transporter signature motif; other site
176299016918	Uncharacterized ABC-type transport system, ATPase component [General function prediction only]; Region: COG4674
176299016919	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
176299016920	Walker A/P-loop; other site
176299016921	ATP binding site [chemical binding]; other site
176299016922	Q-loop/lid; other site
176299016923	ABC transporter signature motif; other site
176299016924	Walker B; other site
176299016925	D-loop; other site
176299016926	H-loop/switch region; other site
176299016927	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
176299016928	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
176299016929	Walker A/P-loop; other site
176299016930	ATP binding site [chemical binding]; other site
176299016931	Q-loop/lid; other site
176299016932	ABC transporter signature motif; other site
176299016933	Walker B; other site
176299016934	D-loop; other site
176299016935	H-loop/switch region; other site
176299016936	First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R1; cd07578
176299016937	putative active site [active]
176299016938	catalytic triad [active]
176299016939	putative dimer interface [polypeptide binding]; other site
176299016940	Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579
176299016941	putative active site [active]
176299016942	catalytic triad [active]
176299016943	putative dimer interface [polypeptide binding]; other site
176299016944	mercuric reductase; Validated; Region: PRK06370
176299016945	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
176299016946	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
176299016947	Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
176299016948	Predicted membrane protein [Function unknown]; Region: COG3918
176299016949	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
176299016950	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
176299016951	Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
176299016952	HlyD family secretion protein; Region: HlyD_3; pfam13437
176299016953	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
176299016954	Predicted membrane protein [Function unknown]; Region: COG1289
176299016955	Fusaric acid resistance protein-like; Region: FUSC_2; cl19401
176299016956	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
176299016957	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299016958	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
176299016959	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
176299016960	Cold shock proteins [Transcription]; Region: CspC; COG1278
176299016961	transcriptional regulator; Provisional; Region: PRK10632
176299016962	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299016963	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
176299016964	putative effector binding pocket; other site
176299016965	putative dimerization interface [polypeptide binding]; other site
176299016966	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
176299016967	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
176299016968	T-DNA (T1) left border
176299016969	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
176299016970	active site
176299016971	catalytic site [active]
176299016972	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016973	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016974	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016975	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016976	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
176299016977	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
176299016978	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299016979	NAD(P) binding site [chemical binding]; other site
176299016980	active site
176299016981	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
176299016982	active site
176299016983	catalytic site [active]
176299016984	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016985	indole acetimide hydrolase; Validated; Region: PRK07488
176299016986	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016987	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
176299016988	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
176299016989	Isopentenyl transferase; Region: IPT; pfam01745
176299016990	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016991	RolB/RolC glucosidase family; Region: RolB_RolC; pfam02027
176299016992	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
176299016993	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
176299016994	T-DNA (T1) right border
176299016995	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
176299016996	ornithine cyclodeaminase; Validated; Region: PRK07589
176299016997	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
176299016998	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
176299016999	Arginase family; Region: Arginase; cd09989
176299017000	active site
176299017001	Mn binding site [ion binding]; other site
176299017002	oligomer interface [polypeptide binding]; other site
176299017003	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
176299017004	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299017005	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
176299017006	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
176299017007	FAD dependent oxidoreductase; Region: DAO; pfam01266
176299017008	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299017009	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
176299017010	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
176299017011	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
176299017012	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
176299017013	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
176299017014	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299017015	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
176299017016	dimerization interface [polypeptide binding]; other site
176299017017	substrate binding pocket [chemical binding]; other site
176299017018	ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160
176299017019	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017020	dimer interface [polypeptide binding]; other site
176299017021	conserved gate region; other site
176299017022	putative PBP binding loops; other site
176299017023	ABC-ATPase subunit interface; other site
176299017024	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
176299017025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017026	dimer interface [polypeptide binding]; other site
176299017027	conserved gate region; other site
176299017028	putative PBP binding loops; other site
176299017029	ABC-ATPase subunit interface; other site
176299017030	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
176299017031	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299017032	substrate binding pocket [chemical binding]; other site
176299017033	membrane-bound complex binding site; other site
176299017034	hinge residues; other site
176299017035	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
176299017036	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
176299017037	Walker A/P-loop; other site
176299017038	ATP binding site [chemical binding]; other site
176299017039	Q-loop/lid; other site
176299017040	ABC transporter signature motif; other site
176299017041	Walker B; other site
176299017042	D-loop; other site
176299017043	H-loop/switch region; other site
176299017044	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299017045	The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415
176299017046	putative dimerization interface [polypeptide binding]; other site
176299017047	conjugal transfer protein TrbI; Provisional; Region: PRK13831
176299017048	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
176299017049	conjugal transfer protein TrbH; Provisional; Region: PRK13835
176299017050	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
176299017051	VirB7 interaction site; other site
176299017052	conjugal transfer protein TrbF; Provisional; Region: PRK13836
176299017053	conjugal transfer protein TrbL; Provisional; Region: PRK13841
176299017054	Protein of unknown function (DUF2749); Region: DUF2749; pfam10907
176299017055	conjugal transfer protein TrbJ; Provisional; Region: PRK13842
176299017056	conjugal transfer protein TrbE; Provisional; Region: PRK13830
176299017057	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
176299017058	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
176299017059	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
176299017060	Walker A/P-loop; other site
176299017061	ATP binding site [chemical binding]; other site
176299017062	conjugal transfer protein TrbD; Provisional; Region: PRK13823
176299017063	conjugal transfer protein TrbC; Provisional; Region: PRK13871
176299017064	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
176299017065	ATP binding site [chemical binding]; other site
176299017066	Walker A motif; other site
176299017067	hexamer interface [polypeptide binding]; other site
176299017068	Walker B motif; other site
176299017069	putative autoinducer synthesis protein; Provisional; Region: PRK13834
176299017070	plasmid-partitioning protein RepA; Provisional; Region: PRK13869
176299017071	MerR family regulatory protein; Region: MerR; pfam00376
176299017072	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
176299017073	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
176299017074	P-loop; other site
176299017075	Magnesium ion binding site [ion binding]; other site
176299017076	plasmid partitioning protein RepB; Provisional; Region: PRK13866
176299017077	ParB-like nuclease domain; Region: ParBc; pfam02195
176299017078	RepB plasmid partitioning protein; Region: RepB; pfam07506
176299017079	replication initiation protein RepC; Provisional; Region: PRK13824
176299017080	Replication protein C N-terminal domain; Region: RP-C; pfam03428
176299017081	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
176299017082	putative DNA binding site [nucleotide binding]; other site
176299017083	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
176299017084	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
176299017085	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
176299017086	catalytic residues [active]
176299017087	catalytic nucleophile [active]
176299017088	Presynaptic Site I dimer interface [polypeptide binding]; other site
176299017089	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
176299017090	Synaptic Flat tetramer interface [polypeptide binding]; other site
176299017091	Synaptic Site I dimer interface [polypeptide binding]; other site
176299017092	DNA binding site [nucleotide binding]
176299017093	Protein of unknown function (DUF1612); Region: DUF1612; pfam07756
176299017094	HTH DNA binding domain; Region: HTH_13; pfam11972
176299017095	Superfamily II helicase [General function prediction only]; Region: COG1204
176299017096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
176299017097	ATP binding site [chemical binding]; other site
176299017098	putative Mg++ binding site [ion binding]; other site
176299017099	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
176299017100	Peptidase U49; Region: Peptidase_U49; cl19913
176299017101	RES domain; Region: RES; pfam08808
176299017102	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
176299017103	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299017104	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
176299017105	dimerization interface [polypeptide binding]; other site
176299017106	substrate binding pocket [chemical binding]; other site
176299017107	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
176299017108	Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
176299017109	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299017110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017111	dimer interface [polypeptide binding]; other site
176299017112	conserved gate region; other site
176299017113	putative PBP binding loops; other site
176299017114	ABC-ATPase subunit interface; other site
176299017115	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
176299017116	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299017117	Walker A/P-loop; other site
176299017118	ATP binding site [chemical binding]; other site
176299017119	Q-loop/lid; other site
176299017120	ABC transporter signature motif; other site
176299017121	Walker B; other site
176299017122	D-loop; other site
176299017123	H-loop/switch region; other site
176299017124	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
176299017125	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299017126	substrate binding pocket [chemical binding]; other site
176299017127	membrane-bound complex binding site; other site
176299017128	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
176299017129	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096
176299017130	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
176299017131	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
176299017132	NAD(P) binding site [chemical binding]; other site
176299017133	active site
176299017134	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
176299017135	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299017136	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
176299017137	haloalkane dehalogenase; Provisional; Region: PRK03592
176299017138	Putative lysophospholipase; Region: Hydrolase_4; cl19140
176299017139	Uncharacterized conserved protein [Function unknown]; Region: COG2128
176299017140	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
176299017141	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
176299017142	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
176299017143	active site
176299017144	Uncharacterized conserved protein [Function unknown]; Region: COG2128
176299017145	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
176299017146	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
176299017147	TM-ABC transporter signature motif; other site
176299017148	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
176299017149	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
176299017150	Walker A/P-loop; other site
176299017151	ATP binding site [chemical binding]; other site
176299017152	Q-loop/lid; other site
176299017153	ABC transporter signature motif; other site
176299017154	Walker B; other site
176299017155	D-loop; other site
176299017156	H-loop/switch region; other site
176299017157	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
176299017158	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
176299017159	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
176299017160	ligand binding site [chemical binding]; other site
176299017161	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
176299017162	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
176299017163	Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163
176299017164	Flavin binding site [chemical binding]; other site
176299017165	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299017166	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
176299017167	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
176299017168	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299017169	Walker A/P-loop; other site
176299017170	ATP binding site [chemical binding]; other site
176299017171	Q-loop/lid; other site
176299017172	ABC transporter signature motif; other site
176299017173	Walker B; other site
176299017174	D-loop; other site
176299017175	H-loop/switch region; other site
176299017176	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299017177	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299017178	Walker A/P-loop; other site
176299017179	ATP binding site [chemical binding]; other site
176299017180	Q-loop/lid; other site
176299017181	ABC transporter signature motif; other site
176299017182	Walker B; other site
176299017183	D-loop; other site
176299017184	H-loop/switch region; other site
176299017185	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299017186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017187	dimer interface [polypeptide binding]; other site
176299017188	conserved gate region; other site
176299017189	putative PBP binding loops; other site
176299017190	ABC-ATPase subunit interface; other site
176299017191	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299017192	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017193	dimer interface [polypeptide binding]; other site
176299017194	conserved gate region; other site
176299017195	putative PBP binding loops; other site
176299017196	ABC-ATPase subunit interface; other site
176299017197	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
176299017198	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
176299017199	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
176299017200	active site
176299017201	dimer interface [polypeptide binding]; other site
176299017202	non-prolyl cis peptide bond; other site
176299017203	insertion regions; other site
176299017204	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
176299017205	active site
176299017206	non-prolyl cis peptide bond; other site
176299017207	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299017208	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299017209	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
176299017210	dimerization interface [polypeptide binding]; other site
176299017211	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
176299017212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
176299017213	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
176299017214	Walker A motif; other site
176299017215	ATP binding site [chemical binding]; other site
176299017216	Walker B motif; other site
176299017217	arginine finger; other site
176299017218	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
176299017219	Subtilase family; Region: Peptidase_S8; pfam00082
176299017220	active site
176299017221	catalytic triad [active]
176299017222	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
176299017223	active site
176299017224	non-prolyl cis peptide bond; other site
176299017225	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
176299017226	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
176299017227	substrate binding pocket [chemical binding]; other site
176299017228	membrane-bound complex binding site; other site
176299017229	hinge residues; other site
176299017230	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
176299017231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017232	dimer interface [polypeptide binding]; other site
176299017233	conserved gate region; other site
176299017234	putative PBP binding loops; other site
176299017235	ABC-ATPase subunit interface; other site
176299017236	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
176299017237	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
176299017238	Walker A/P-loop; other site
176299017239	ATP binding site [chemical binding]; other site
176299017240	Q-loop/lid; other site
176299017241	ABC transporter signature motif; other site
176299017242	Walker B; other site
176299017243	D-loop; other site
176299017244	H-loop/switch region; other site
176299017245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
176299017246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
176299017247	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
176299017248	dimerization interface [polypeptide binding]; other site
176299017249	Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532
176299017250	active site residue [active]
176299017251	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
176299017252	active site residue [active]
176299017253	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
176299017254	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
176299017255	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
176299017256	active site
176299017257	DNA binding site [nucleotide binding]
176299017258	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
176299017259	DNA binding site [nucleotide binding]
176299017260	Uncharacterized conserved protein [Function unknown]; Region: COG4544
176299017261	DNA Polymerase Y-family; Region: PolY_like; cd03468
176299017262	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
176299017263	DNA binding site [nucleotide binding]
176299017264	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
176299017265	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
176299017266	putative active site [active]
176299017267	putative PHP Thumb interface [polypeptide binding]; other site
176299017268	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
176299017269	Helix-hairpin-helix motif; Region: HHH_6; pfam14579
176299017270	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
176299017271	generic binding surface I; other site
176299017272	generic binding surface II; other site
176299017273	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
176299017274	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
176299017275	active site
176299017276	metal binding site [ion binding]; metal-binding site
176299017277	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
176299017278	mobile mystery protein B; Region: mob_myst_B; TIGR02613
176299017279	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
176299017280	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
176299017281	non-specific DNA binding site [nucleotide binding]; other site
176299017282	salt bridge; other site
176299017283	sequence-specific DNA binding site [nucleotide binding]; other site
176299017284	Protein of unknown function (DUF1419); Region: DUF1419; pfam07215
176299017285	Protein of unknown function (DUF3085); Region: DUF3085; pfam11284
176299017286	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
176299017287	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
176299017288	S-adenosylmethionine binding site [chemical binding]; other site
176299017289	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
176299017290	DEAD-like helicases superfamily; Region: DEXDc; smart00487
176299017291	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
176299017292	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
176299017293	helicase superfamily c-terminal domain; Region: HELICc; smart00490
176299017294	plasmid partitioning protein; Provisional; Region: PRK13832
176299017295	ParB-like nuclease domain; Region: ParB; smart00470
176299017296	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
176299017297	PhnA protein; Region: PhnA; pfam03831
176299017298	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
176299017299	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
176299017300	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
176299017301	Ligand Binding Site [chemical binding]; other site
176299017302	Uncharacterized conserved protein [Function unknown]; Region: COG5489
176299017303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
176299017304	AAA domain; Region: AAA_33; pfam13671
176299017305	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
176299017306	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_36; cd04695
176299017307	nudix motif; other site
176299017308	Uncharacterized conserved protein [Function unknown]; Region: COG5489
176299017309	DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cd00591
176299017310	DNA binding site [nucleotide binding]
176299017311	dimer interface [polypeptide binding]; other site
176299017312	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
176299017313	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
176299017314	Staphylococcal nuclease homologue; Region: SNase; cl00140
176299017315	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
176299017316	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
176299017317	Walker A motif; other site
176299017318	ATP binding site [chemical binding]; other site
176299017319	Walker B motif; other site
176299017320	conjugal transfer protein TraD; Provisional; Region: PRK13847
176299017321	conjugal transfer protein TraC; Provisional; Region: PRK13848
176299017322	Dtr system oriT relaxase; Provisional; Region: PRK13826
176299017323	MobA/MobL family; Region: MobA_MobL; pfam03389
176299017324	AAA domain; Region: AAA_30; pfam13604
176299017325	UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
176299017326	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
176299017327	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
176299017328	conjugal transfer protein TraB; Provisional; Region: PRK13825
176299017329	active site
176299017330	catalytic triad [active]
176299017331	conjugal transfer protein TraH; Provisional; Region: PRK13843
176299017332	Prokaryotic Transcriptional repressor TraM; Region: Prok-TraM; pfam09228
176299017333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299017334	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
176299017335	putative active site [active]
176299017336	heme pocket [chemical binding]; other site
176299017337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
176299017338	putative active site [active]
176299017339	heme pocket [chemical binding]; other site
176299017340	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
176299017341	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
176299017342	dimer interface [polypeptide binding]; other site
176299017343	putative CheW interface [polypeptide binding]; other site
176299017344	transcriptional regulator TraR; Provisional; Region: PRK13870
176299017345	Autoinducer binding domain; Region: Autoind_bind; pfam03472
176299017346	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
176299017347	DNA binding residues [nucleotide binding]
176299017348	dimerization interface [polypeptide binding]; other site
176299017349	sucrose phosphorylase; Provisional; Region: PRK13840
176299017350	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
176299017351	active site
176299017352	homodimer interface [polypeptide binding]; other site
176299017353	catalytic site [active]
176299017354	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
176299017355	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
176299017356	PhoU domain; Region: PhoU; pfam01895
176299017357	PhoU domain; Region: PhoU; pfam01895
176299017358	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
176299017359	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
176299017360	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
176299017361	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
176299017362	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
176299017363	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
176299017364	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299017365	Walker A/P-loop; other site
176299017366	ATP binding site [chemical binding]; other site
176299017367	Q-loop/lid; other site
176299017368	ABC transporter signature motif; other site
176299017369	Walker B; other site
176299017370	D-loop; other site
176299017371	H-loop/switch region; other site
176299017372	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299017373	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
176299017374	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
176299017375	Walker A/P-loop; other site
176299017376	ATP binding site [chemical binding]; other site
176299017377	Q-loop/lid; other site
176299017378	ABC transporter signature motif; other site
176299017379	Walker B; other site
176299017380	D-loop; other site
176299017381	H-loop/switch region; other site
176299017382	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
176299017383	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
176299017384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017385	dimer interface [polypeptide binding]; other site
176299017386	conserved gate region; other site
176299017387	putative PBP binding loops; other site
176299017388	ABC-ATPase subunit interface; other site
176299017389	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
176299017390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
176299017391	dimer interface [polypeptide binding]; other site
176299017392	conserved gate region; other site
176299017393	putative PBP binding loops; other site
176299017394	ABC-ATPase subunit interface; other site
176299017395	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
176299017396	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
176299017397	active site
176299017398	catalytic site [active]
176299017399	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
176299017400	active site
176299017401	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
176299017402	nudix motif; other site
176299017403	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
176299017404	active site
176299017405	catalytic residues [active]
176299017406	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
176299017407	DNA binding residues [nucleotide binding]
176299017408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
176299017409	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
176299017410	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
176299017411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
176299017412	Transposase; Region: DEDD_Tnp_IS110; pfam01548
176299017413	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
176299017414	VirK protein; Region: VirK; pfam06903
176299017415	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
176299017416	HipA-like N-terminal domain; Region: HipA_N; pfam07805
176299017417	HipA-like C-terminal domain; Region: HipA_C; pfam07804
176299017418	Transposase; Region: HTH_Tnp_1; pfam01527
176299017419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
176299017420	UTRA domain; Region: UTRA; cl17743
176299017421	Isopentenyl transferase; Region: IPT; pfam01745
176299017422	two-component VirA-like sensor kinase; Provisional; Region: PRK13837
176299017423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
176299017424	dimer interface [polypeptide binding]; other site
176299017425	phosphorylation site [posttranslational modification]
176299017426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
176299017427	ATP binding site [chemical binding]; other site
176299017428	Mg2+ binding site [ion binding]; other site
176299017429	G-X-G motif; other site
176299017430	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
176299017431	N-acetyl-D-glucosamine binding site [chemical binding]; other site
176299017432	catalytic residue [active]
176299017433	type IV secretion system pilin subunit VirB2; Provisional; Region: PRK13857
176299017434	type IV secretion system protein VirB3; Provisional; Region: PRK13854
176299017435	type IV secretion system protein VirB4; Provisional; Region: PRK13853
176299017436	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
176299017437	AAA domain; Region: AAA_23; pfam13476
176299017438	type IV secretion system protein VirB5; Provisional; Region: PRK13860
176299017439	type IV secretion system protein VirB6; Provisional; Region: PRK13852
176299017440	type IV secretion system lipoprotein VirB7; Provisional; Region: PRK13859
176299017441	type IV secretion system protein VirB8; Provisional; Region: PRK13865
176299017442	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
176299017443	VirB7 interaction site; other site
176299017444	type IV secretion system protein VirB10; Provisional; Region: PRK13855
176299017445	Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948
176299017446	type IV secretion system protein VirB11; Provisional; Region: PRK13851
176299017447	Walker A motif; other site
176299017448	ATP binding site [chemical binding]; other site
176299017449	Walker B motif; other site
176299017450	two-component response regulator VirG; Provisional; Region: PRK13856
176299017451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
176299017452	active site
176299017453	phosphorylation site [posttranslational modification]
176299017454	intermolecular recognition site; other site
176299017455	dimerization interface [polypeptide binding]; other site
176299017456	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
176299017457	DNA binding site [nucleotide binding]
176299017458	VirC2 protein; Region: VirC2; pfam07181
176299017459	putative crown gall tumor protein VirC1; Provisional; Region: PRK13849
176299017460	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
176299017461	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
176299017462	P-loop; other site
176299017463	Magnesium ion binding site [ion binding]; other site
176299017464	T-DNA border endonuclease VirD1; Region: VirD1; pfam07328
176299017465	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
176299017466	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
176299017467	type IV secretion system protein VirD4; Provisional; Region: PRK13850
176299017468	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
176299017469	Walker A motif; other site
176299017470	ATP binding site [chemical binding]; other site
176299017471	Walker B motif; other site
176299017472	Agrobacterium VirD5 protein; Region: Agro_virD5; smart00795
176299017473	VirE3; Region: VirE3; pfam06661
176299017474	type IV secretion system chaperone VirE1; Provisional; Region: PRK13867
176299017475	type IV secretion system single-stranded DNA binding protein VirE2; Provisional; Region: PRK13868
176299017476	VirE3; Region: VirE3; pfam06661
176299017477	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
176299017478	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
176299017479	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
176299017480	nudix motif; other site
176299017481	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
176299017482	active site