-- dump date 20140618_191811 -- class Genbank::misc_feature -- table misc_feature_note -- id note 446462000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462000002 Walker A motif; other site 446462000003 ATP binding site [chemical binding]; other site 446462000004 Walker B motif; other site 446462000005 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 446462000006 DnaA box-binding interface [nucleotide binding]; other site 446462000007 DNA polymerase III subunit beta; Validated; Region: PRK07761 446462000008 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446462000009 putative DNA binding surface [nucleotide binding]; other site 446462000010 dimer interface [polypeptide binding]; other site 446462000011 beta-clamp/clamp loader binding surface; other site 446462000012 beta-clamp/translesion DNA polymerase binding surface; other site 446462000013 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446462000014 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 446462000015 recombination protein F; Reviewed; Region: recF; PRK00064 446462000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 446462000017 Walker A/P-loop; other site 446462000018 ATP binding site [chemical binding]; other site 446462000019 Q-loop/lid; other site 446462000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462000021 ABC transporter signature motif; other site 446462000022 Walker B; other site 446462000023 D-loop; other site 446462000024 H-loop/switch region; other site 446462000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 446462000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 446462000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462000028 ATP binding site [chemical binding]; other site 446462000029 Mg2+ binding site [ion binding]; other site 446462000030 G-X-G motif; other site 446462000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446462000032 anchoring element; other site 446462000033 dimer interface [polypeptide binding]; other site 446462000034 ATP binding site [chemical binding]; other site 446462000035 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446462000036 active site 446462000037 metal binding site [ion binding]; metal-binding site 446462000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446462000039 DNA gyrase subunit A; Validated; Region: PRK05560 446462000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446462000041 CAP-like domain; other site 446462000042 active site 446462000043 primary dimer interface [polypeptide binding]; other site 446462000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446462000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446462000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446462000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446462000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446462000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446462000050 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 446462000051 DoxX; Region: DoxX; pfam07681 446462000052 Predicted membrane protein [Function unknown]; Region: COG2259 446462000053 Domain of unknown function (DUF2020); Region: DUF2020; pfam09449 446462000054 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 446462000055 active site 446462000056 Rhomboid family; Region: Rhomboid; pfam01694 446462000057 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446462000058 putative septation inhibitor protein; Reviewed; Region: PRK00159 446462000059 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 446462000060 active site 446462000061 catalytic site [active] 446462000062 ferredoxin-NADP+ reductase; Region: PLN02852 446462000063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462000064 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446462000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446462000066 glutamine binding [chemical binding]; other site 446462000067 catalytic triad [active] 446462000068 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462000069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462000070 active site 446462000071 ATP binding site [chemical binding]; other site 446462000072 substrate binding site [chemical binding]; other site 446462000073 activation loop (A-loop); other site 446462000074 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 446462000075 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462000076 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462000077 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462000078 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462000079 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462000080 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462000081 active site 446462000082 ATP binding site [chemical binding]; other site 446462000083 substrate binding site [chemical binding]; other site 446462000084 activation loop (A-loop); other site 446462000085 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446462000086 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 446462000087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446462000088 active site 446462000089 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446462000090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446462000091 phosphopeptide binding site; other site 446462000092 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 446462000093 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446462000094 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446462000095 phosphopeptide binding site; other site 446462000096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462000097 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462000098 NAD(P) binding site [chemical binding]; other site 446462000099 active site 446462000100 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446462000101 FAD binding domain; Region: FAD_binding_4; pfam01565 446462000102 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446462000103 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446462000104 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446462000105 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462000106 catalytic residue [active] 446462000107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462000108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462000109 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446462000110 beta-galactosidase; Region: BGL; TIGR03356 446462000111 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 446462000112 short chain dehydrogenase; Provisional; Region: PRK07024 446462000113 classical (c) SDRs; Region: SDR_c; cd05233 446462000114 NAD(P) binding site [chemical binding]; other site 446462000115 active site 446462000116 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462000117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462000118 salt bridge; other site 446462000119 non-specific DNA binding site [nucleotide binding]; other site 446462000120 sequence-specific DNA binding site [nucleotide binding]; other site 446462000121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462000122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462000123 TPR motif; other site 446462000124 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462000125 binding surface 446462000126 Phosphotransferase enzyme family; Region: APH; pfam01636 446462000127 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462000128 CopC domain; Region: CopC; pfam04234 446462000129 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 446462000130 BCCT family transporter; Region: BCCT; pfam02028 446462000131 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 446462000132 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 446462000133 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446462000134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462000135 NAD(P) binding site [chemical binding]; other site 446462000136 active site 446462000137 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 446462000138 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 446462000139 DHHW protein; Region: DHHW; pfam14286 446462000140 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446462000141 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 446462000142 Probable Catalytic site; other site 446462000143 metal-binding site 446462000144 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462000145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462000146 S-adenosylmethionine binding site [chemical binding]; other site 446462000147 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462000148 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 446462000149 Probable Catalytic site; other site 446462000150 Short C-terminal domain; Region: SHOCT; pfam09851 446462000151 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462000152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462000153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462000154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462000155 S-adenosylmethionine binding site [chemical binding]; other site 446462000156 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 446462000157 RNA polymerase sigma factor; Reviewed; Region: PRK05602 446462000158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462000159 Putative zinc-finger; Region: zf-HC2; pfam13490 446462000160 Histidine kinase; Region: His_kinase; pfam06580 446462000161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462000162 ATP binding site [chemical binding]; other site 446462000163 Mg2+ binding site [ion binding]; other site 446462000164 G-X-G motif; other site 446462000165 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 446462000166 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 446462000167 tandem repeat interface [polypeptide binding]; other site 446462000168 oligomer interface [polypeptide binding]; other site 446462000169 active site residues [active] 446462000170 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 446462000171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462000172 active site 446462000173 phosphorylation site [posttranslational modification] 446462000174 intermolecular recognition site; other site 446462000175 dimerization interface [polypeptide binding]; other site 446462000176 LytTr DNA-binding domain; Region: LytTR; smart00850 446462000177 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446462000178 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446462000179 Na binding site [ion binding]; other site 446462000180 Protein of unknown function, DUF485; Region: DUF485; pfam04341 446462000181 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446462000182 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 446462000183 Na binding site [ion binding]; other site 446462000184 Helix-turn-helix domain; Region: HTH_17; cl17695 446462000185 PIN domain; Region: PIN_3; pfam13470 446462000186 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446462000187 active site residue [active] 446462000188 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 446462000189 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 446462000190 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446462000191 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446462000192 active site 446462000193 catalytic site [active] 446462000194 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462000195 Cytochrome P450; Region: p450; cl12078 446462000196 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446462000197 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446462000198 active site 446462000199 catalytic site [active] 446462000200 SEC-C motif; Region: SEC-C; pfam02810 446462000201 Protein of unknown function (DUF952); Region: DUF952; cl01393 446462000202 Haem-containing dehydratase; Region: Dehydratase_hem; pfam13816 446462000203 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 446462000204 Ferritin-like domain; Region: Ferritin; pfam00210 446462000205 ferroxidase diiron center [ion binding]; other site 446462000206 arginine deiminase; Provisional; Region: PRK01388 446462000207 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446462000208 CAAX protease self-immunity; Region: Abi; pfam02517 446462000209 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 446462000210 fumarylacetoacetase; Region: PLN02856 446462000211 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 446462000212 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446462000213 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446462000214 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446462000215 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446462000216 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446462000217 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446462000218 TIR domain; Region: TIR_2; pfam13676 446462000219 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462000220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462000221 Walker A/P-loop; other site 446462000222 ATP binding site [chemical binding]; other site 446462000223 ABC transporter; Region: ABC_tran; pfam00005 446462000224 Q-loop/lid; other site 446462000225 ABC transporter signature motif; other site 446462000226 Walker B; other site 446462000227 D-loop; other site 446462000228 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 446462000229 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462000230 Walker A/P-loop; other site 446462000231 ATP binding site [chemical binding]; other site 446462000232 Q-loop/lid; other site 446462000233 ABC transporter signature motif; other site 446462000234 Walker B; other site 446462000235 D-loop; other site 446462000236 H-loop/switch region; other site 446462000237 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462000238 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462000239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462000240 Histidine kinase; Region: HisKA_3; pfam07730 446462000241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462000242 ATP binding site [chemical binding]; other site 446462000243 Mg2+ binding site [ion binding]; other site 446462000244 G-X-G motif; other site 446462000245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462000246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462000247 active site 446462000248 phosphorylation site [posttranslational modification] 446462000249 intermolecular recognition site; other site 446462000250 dimerization interface [polypeptide binding]; other site 446462000251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462000252 DNA binding residues [nucleotide binding] 446462000253 dimerization interface [polypeptide binding]; other site 446462000254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446462000255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462000256 Coenzyme A binding pocket [chemical binding]; other site 446462000257 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 446462000258 ADP-ribose binding site [chemical binding]; other site 446462000259 prephenate dehydratase; Provisional; Region: PRK11898 446462000260 Prephenate dehydratase; Region: PDT; pfam00800 446462000261 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 446462000262 putative L-Phe binding site [chemical binding]; other site 446462000263 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462000264 catalytic core [active] 446462000265 Immunity protein Imm1; Region: Imm1; pfam14430 446462000266 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446462000267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462000268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462000269 non-specific DNA binding site [nucleotide binding]; other site 446462000270 salt bridge; other site 446462000271 sequence-specific DNA binding site [nucleotide binding]; other site 446462000272 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462000273 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 446462000274 active site 446462000275 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 446462000276 putative metal binding site [ion binding]; other site 446462000277 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 446462000278 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 446462000279 active site 446462000280 catalytic site [active] 446462000281 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462000282 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462000283 putative sugar binding sites [chemical binding]; other site 446462000284 Q-X-W motif; other site 446462000285 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462000286 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462000287 putative sugar binding sites [chemical binding]; other site 446462000288 Q-X-W motif; other site 446462000289 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 446462000290 Septum formation; Region: Septum_form; pfam13845 446462000291 Septum formation; Region: Septum_form; pfam13845 446462000292 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 446462000293 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 446462000294 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 446462000295 seryl-tRNA synthetase; Provisional; Region: PRK05431 446462000296 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446462000297 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 446462000298 dimer interface [polypeptide binding]; other site 446462000299 active site 446462000300 motif 1; other site 446462000301 motif 2; other site 446462000302 motif 3; other site 446462000303 Predicted dehydrogenase [General function prediction only]; Region: COG0579 446462000304 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446462000305 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446462000306 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462000307 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 446462000308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462000309 active site 446462000310 motif I; other site 446462000311 motif II; other site 446462000312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462000313 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 446462000314 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 446462000315 Ligand binding site; other site 446462000316 Putative Catalytic site; other site 446462000317 DXD motif; other site 446462000318 Predicted membrane protein [Function unknown]; Region: COG2246 446462000319 GtrA-like protein; Region: GtrA; pfam04138 446462000320 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462000321 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462000322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462000323 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462000324 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446462000325 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 446462000326 Probable Catalytic site; other site 446462000327 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 446462000328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462000329 UDP-galactopyranose mutase; Region: GLF; pfam03275 446462000330 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446462000331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462000332 active site 446462000333 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446462000334 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446462000335 Walker A/P-loop; other site 446462000336 ATP binding site [chemical binding]; other site 446462000337 Q-loop/lid; other site 446462000338 ABC transporter signature motif; other site 446462000339 Walker B; other site 446462000340 D-loop; other site 446462000341 H-loop/switch region; other site 446462000342 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 446462000343 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446462000344 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 446462000345 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446462000346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462000347 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462000348 catalytic residue [active] 446462000349 Methyltransferase domain; Region: Methyltransf_24; pfam13578 446462000350 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446462000351 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 446462000352 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 446462000353 NAD(P) binding site [chemical binding]; other site 446462000354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462000355 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462000356 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446462000357 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 446462000358 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 446462000359 Peptidase family M28; Region: Peptidase_M28; pfam04389 446462000360 active site 446462000361 metal binding site [ion binding]; metal-binding site 446462000362 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446462000363 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 446462000364 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 446462000365 putative active site [active] 446462000366 putative metal binding site [ion binding]; other site 446462000367 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446462000368 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462000369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462000370 putative DNA binding site [nucleotide binding]; other site 446462000371 putative Zn2+ binding site [ion binding]; other site 446462000372 hypothetical protein; Provisional; Region: PRK10621 446462000373 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446462000374 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 446462000375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462000376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462000377 homodimer interface [polypeptide binding]; other site 446462000378 catalytic residue [active] 446462000379 Dienelactone hydrolase family; Region: DLH; pfam01738 446462000380 EspG family; Region: ESX-1_EspG; pfam14011 446462000381 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 446462000382 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462000383 acyl-activating enzyme (AAE) consensus motif; other site 446462000384 AMP binding site [chemical binding]; other site 446462000385 active site 446462000386 CoA binding site [chemical binding]; other site 446462000387 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462000388 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462000389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462000390 active site 446462000391 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462000392 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446462000393 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446462000394 cofactor binding site; other site 446462000395 DNA binding site [nucleotide binding] 446462000396 substrate interaction site [chemical binding]; other site 446462000397 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446462000398 TQXA domain; Region: TQXA_dom; TIGR03934 446462000399 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 446462000400 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 446462000401 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 446462000402 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446462000403 dimer interface [polypeptide binding]; other site 446462000404 active site 446462000405 prephenate dehydrogenase; Validated; Region: PRK06545 446462000406 prephenate dehydrogenase; Validated; Region: PRK08507 446462000407 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446462000408 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 446462000409 metal binding site [ion binding]; metal-binding site 446462000410 dimer interface [polypeptide binding]; other site 446462000411 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 446462000412 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446462000413 nucleoside/Zn binding site; other site 446462000414 dimer interface [polypeptide binding]; other site 446462000415 catalytic motif [active] 446462000416 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446462000417 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462000418 active site 446462000419 DNA binding site [nucleotide binding] 446462000420 Int/Topo IB signature motif; other site 446462000421 Helix-turn-helix domain; Region: HTH_17; cl17695 446462000422 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 446462000423 Protein of unknown function (DUF2742); Region: DUF2742; pfam10888 446462000424 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 446462000425 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462000426 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 446462000427 non-specific DNA binding site [nucleotide binding]; other site 446462000428 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 446462000429 salt bridge; other site 446462000430 sequence-specific DNA binding site [nucleotide binding]; other site 446462000431 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 446462000432 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462000433 DDE superfamily endonuclease; Region: DDE_4; pfam13359 446462000434 hypothetical protein; Provisional; Region: PRK09266 446462000435 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446462000436 homodimer interface [polypeptide binding]; other site 446462000437 substrate-cofactor binding pocket; other site 446462000438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462000439 catalytic residue [active] 446462000440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462000441 non-specific DNA binding site [nucleotide binding]; other site 446462000442 salt bridge; other site 446462000443 sequence-specific DNA binding site [nucleotide binding]; other site 446462000444 Uncharacterized conserved protein [Function unknown]; Region: COG1262 446462000445 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446462000446 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 446462000447 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 446462000448 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446462000449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462000450 S-adenosylmethionine binding site [chemical binding]; other site 446462000451 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 446462000452 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 446462000453 RxxxH motif; other site 446462000454 putative ATP-grasp target RiPP; Region: GRASP_targ; TIGR04186 446462000455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462000456 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462000457 non-specific DNA binding site [nucleotide binding]; other site 446462000458 salt bridge; other site 446462000459 sequence-specific DNA binding site [nucleotide binding]; other site 446462000460 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 446462000461 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 446462000462 generic binding surface I; other site 446462000463 generic binding surface II; other site 446462000464 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446462000465 putative catalytic site [active] 446462000466 putative metal binding site [ion binding]; other site 446462000467 putative phosphate binding site [ion binding]; other site 446462000468 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446462000469 homotrimer interaction site [polypeptide binding]; other site 446462000470 putative active site [active] 446462000471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462000472 WHG domain; Region: WHG; pfam13305 446462000473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462000474 dimerization interface [polypeptide binding]; other site 446462000475 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462000476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462000477 dimer interface [polypeptide binding]; other site 446462000478 putative CheW interface [polypeptide binding]; other site 446462000479 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 446462000480 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446462000481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446462000482 dimerization interface [polypeptide binding]; other site 446462000483 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462000484 dimer interface [polypeptide binding]; other site 446462000485 putative CheW interface [polypeptide binding]; other site 446462000486 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 446462000487 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446462000488 siderophore binding site; other site 446462000489 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 446462000490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462000491 Walker A motif; other site 446462000492 ATP binding site [chemical binding]; other site 446462000493 Walker B motif; other site 446462000494 arginine finger; other site 446462000495 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 446462000496 hypothetical protein; Validated; Region: PRK00153 446462000497 recombination protein RecR; Reviewed; Region: recR; PRK00076 446462000498 RecR protein; Region: RecR; pfam02132 446462000499 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 446462000500 putative active site [active] 446462000501 putative metal-binding site [ion binding]; other site 446462000502 tetramer interface [polypeptide binding]; other site 446462000503 hypothetical protein; Provisional; Region: PRK06547 446462000504 AAA domain; Region: AAA_18; pfam13238 446462000505 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462000506 DNA binding site [nucleotide binding] 446462000507 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462000508 AAA ATPase domain; Region: AAA_16; pfam13191 446462000509 NB-ARC domain; Region: NB-ARC; pfam00931 446462000510 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462000511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462000512 binding surface 446462000513 TPR motif; other site 446462000514 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462000515 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462000516 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 446462000517 peptide binding site [polypeptide binding]; other site 446462000518 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462000519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462000520 dimer interface [polypeptide binding]; other site 446462000521 conserved gate region; other site 446462000522 putative PBP binding loops; other site 446462000523 ABC-ATPase subunit interface; other site 446462000524 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 446462000525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462000526 dimer interface [polypeptide binding]; other site 446462000527 conserved gate region; other site 446462000528 putative PBP binding loops; other site 446462000529 ABC-ATPase subunit interface; other site 446462000530 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446462000531 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462000532 Walker A/P-loop; other site 446462000533 ATP binding site [chemical binding]; other site 446462000534 Q-loop/lid; other site 446462000535 ABC transporter signature motif; other site 446462000536 Walker B; other site 446462000537 D-loop; other site 446462000538 H-loop/switch region; other site 446462000539 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462000540 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 446462000541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462000542 Walker A/P-loop; other site 446462000543 ATP binding site [chemical binding]; other site 446462000544 Q-loop/lid; other site 446462000545 ABC transporter signature motif; other site 446462000546 Walker B; other site 446462000547 D-loop; other site 446462000548 H-loop/switch region; other site 446462000549 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446462000550 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 446462000551 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446462000552 2-isopropylmalate synthase; Validated; Region: PRK03739 446462000553 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 446462000554 active site 446462000555 catalytic residues [active] 446462000556 metal binding site [ion binding]; metal-binding site 446462000557 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446462000558 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 446462000559 putative FMN binding site [chemical binding]; other site 446462000560 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 446462000561 aspartate kinase; Reviewed; Region: PRK06635 446462000562 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 446462000563 putative nucleotide binding site [chemical binding]; other site 446462000564 putative catalytic residues [active] 446462000565 putative Mg ion binding site [ion binding]; other site 446462000566 putative aspartate binding site [chemical binding]; other site 446462000567 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 446462000568 putative allosteric regulatory site; other site 446462000569 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 446462000570 putative allosteric regulatory residue; other site 446462000571 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 446462000572 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446462000573 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 446462000574 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 446462000575 N- and C-terminal domain interface [polypeptide binding]; other site 446462000576 active site 446462000577 catalytic site [active] 446462000578 metal binding site [ion binding]; metal-binding site 446462000579 carbohydrate binding site [chemical binding]; other site 446462000580 ATP binding site [chemical binding]; other site 446462000581 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446462000582 DNA-binding site [nucleotide binding]; DNA binding site 446462000583 RNA-binding motif; other site 446462000584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462000585 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446462000586 putative substrate translocation pore; other site 446462000587 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 446462000588 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 446462000589 heme binding pocket [chemical binding]; other site 446462000590 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 446462000591 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 446462000592 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446462000593 dimerization interface [polypeptide binding]; other site 446462000594 DPS ferroxidase diiron center [ion binding]; other site 446462000595 ion pore; other site 446462000596 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446462000597 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446462000598 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446462000599 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 446462000600 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462000601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462000602 S-adenosylmethionine binding site [chemical binding]; other site 446462000603 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446462000604 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462000605 putative active site [active] 446462000606 putative metal binding site [ion binding]; other site 446462000607 Yqey-like protein; Region: YqeY; cl17540 446462000608 Transglycosylase; Region: Transgly; pfam00912 446462000609 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446462000610 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446462000611 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462000612 Transcription factor WhiB; Region: Whib; pfam02467 446462000613 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 446462000614 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446462000615 DTAP/Switch II; other site 446462000616 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446462000617 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 446462000618 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446462000619 DTAP/Switch II; other site 446462000620 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 446462000621 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446462000622 homotrimer interaction site [polypeptide binding]; other site 446462000623 putative active site [active] 446462000624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462000625 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462000626 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446462000627 DNA polymerase III subunit beta; Validated; Region: PRK07761 446462000628 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446462000629 putative DNA binding surface [nucleotide binding]; other site 446462000630 dimer interface [polypeptide binding]; other site 446462000631 beta-clamp/clamp loader binding surface; other site 446462000632 beta-clamp/translesion DNA polymerase binding surface; other site 446462000633 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462000634 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462000635 ligand binding site [chemical binding]; other site 446462000636 flexible hinge region; other site 446462000637 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446462000638 putative switch regulator; other site 446462000639 non-specific DNA interactions [nucleotide binding]; other site 446462000640 DNA binding site [nucleotide binding] 446462000641 sequence specific DNA binding site [nucleotide binding]; other site 446462000642 putative cAMP binding site [chemical binding]; other site 446462000643 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446462000644 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446462000645 minor groove reading motif; other site 446462000646 helix-hairpin-helix signature motif; other site 446462000647 substrate binding pocket [chemical binding]; other site 446462000648 active site 446462000649 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 446462000650 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446462000651 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446462000652 catalytic residues [active] 446462000653 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 446462000654 putative active site [active] 446462000655 putative CoA binding site [chemical binding]; other site 446462000656 nudix motif; other site 446462000657 metal binding site [ion binding]; metal-binding site 446462000658 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446462000659 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446462000660 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462000661 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462000662 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446462000663 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 446462000664 acetyl-CoA synthetase; Provisional; Region: PRK00174 446462000665 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 446462000666 active site 446462000667 CoA binding site [chemical binding]; other site 446462000668 acyl-activating enzyme (AAE) consensus motif; other site 446462000669 AMP binding site [chemical binding]; other site 446462000670 acetate binding site [chemical binding]; other site 446462000671 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446462000672 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462000673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462000674 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462000675 kynureninase; Region: kynureninase; TIGR01814 446462000676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462000677 catalytic residue [active] 446462000678 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 446462000679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462000680 putative DNA binding site [nucleotide binding]; other site 446462000681 putative Zn2+ binding site [ion binding]; other site 446462000682 AsnC family; Region: AsnC_trans_reg; pfam01037 446462000683 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 446462000684 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 446462000685 putative active site [active] 446462000686 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446462000687 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446462000688 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446462000689 putative active site [active] 446462000690 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462000691 Beta-lactamase; Region: Beta-lactamase; cl17358 446462000692 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 446462000693 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462000694 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446462000695 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446462000696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462000697 motif II; other site 446462000698 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446462000699 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446462000700 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 446462000701 ATP binding site [chemical binding]; other site 446462000702 Walker A motif; other site 446462000703 hexamer interface [polypeptide binding]; other site 446462000704 Walker B motif; other site 446462000705 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 446462000706 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 446462000707 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 446462000708 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 446462000709 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 446462000710 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462000711 ATP binding site [chemical binding]; other site 446462000712 putative Mg++ binding site [ion binding]; other site 446462000713 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462000714 nucleotide binding region [chemical binding]; other site 446462000715 ATP-binding site [chemical binding]; other site 446462000716 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446462000717 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 446462000718 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 446462000719 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 446462000720 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 446462000721 active site 446462000722 interdomain interaction site; other site 446462000723 putative metal-binding site [ion binding]; other site 446462000724 nucleotide binding site [chemical binding]; other site 446462000725 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 446462000726 domain I; other site 446462000727 phosphate binding site [ion binding]; other site 446462000728 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 446462000729 domain II; other site 446462000730 domain III; other site 446462000731 nucleotide binding site [chemical binding]; other site 446462000732 DNA binding groove [nucleotide binding] 446462000733 catalytic site [active] 446462000734 domain IV; other site 446462000735 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446462000736 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446462000737 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446462000738 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462000739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462000740 putative substrate translocation pore; other site 446462000741 thymidylate kinase; Provisional; Region: PRK13975; cl17243 446462000742 thymidylate kinase; Validated; Region: tmk; PRK00698 446462000743 DNA polymerase III subunit delta'; Validated; Region: PRK07940 446462000744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462000745 Walker A motif; other site 446462000746 ATP binding site [chemical binding]; other site 446462000747 Walker B motif; other site 446462000748 arginine finger; other site 446462000749 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462000750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462000751 ABC-ATPase subunit interface; other site 446462000752 dimer interface [polypeptide binding]; other site 446462000753 putative PBP binding regions; other site 446462000754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462000755 ABC-ATPase subunit interface; other site 446462000756 dimer interface [polypeptide binding]; other site 446462000757 putative PBP binding regions; other site 446462000758 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446462000759 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446462000760 siderophore binding site; other site 446462000761 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462000762 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462000763 Walker A/P-loop; other site 446462000764 ATP binding site [chemical binding]; other site 446462000765 Q-loop/lid; other site 446462000766 ABC transporter signature motif; other site 446462000767 Walker B; other site 446462000768 D-loop; other site 446462000769 H-loop/switch region; other site 446462000770 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 446462000771 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462000772 Excalibur calcium-binding domain; Region: Excalibur; smart00894 446462000773 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 446462000774 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 446462000775 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446462000776 CoenzymeA binding site [chemical binding]; other site 446462000777 subunit interaction site [polypeptide binding]; other site 446462000778 PHB binding site; other site 446462000779 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462000780 MarR family; Region: MarR; pfam01047 446462000781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462000782 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446462000783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462000784 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 446462000785 dimer interface [polypeptide binding]; other site 446462000786 substrate binding site [chemical binding]; other site 446462000787 metal binding sites [ion binding]; metal-binding site 446462000788 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 446462000789 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 446462000790 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 446462000791 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446462000792 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 446462000793 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 446462000794 Ligand Binding Site [chemical binding]; other site 446462000795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462000796 active site 446462000797 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446462000798 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446462000799 metal ion-dependent adhesion site (MIDAS); other site 446462000800 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 446462000801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462000802 Walker A motif; other site 446462000803 ATP binding site [chemical binding]; other site 446462000804 Walker B motif; other site 446462000805 arginine finger; other site 446462000806 Peptidase family M41; Region: Peptidase_M41; pfam01434 446462000807 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 446462000808 GTP cyclohydrolase I; Provisional; Region: PLN03044 446462000809 active site 446462000810 dihydropteroate synthase; Region: DHPS; TIGR01496 446462000811 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446462000812 substrate binding pocket [chemical binding]; other site 446462000813 dimer interface [polypeptide binding]; other site 446462000814 inhibitor binding site; inhibition site 446462000815 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 446462000816 homooctamer interface [polypeptide binding]; other site 446462000817 active site 446462000818 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 446462000819 catalytic center binding site [active] 446462000820 ATP binding site [chemical binding]; other site 446462000821 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 446462000822 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 446462000823 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 446462000824 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 446462000825 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 446462000826 Protease prsW family; Region: PrsW-protease; pfam13367 446462000827 Rossmann-like domain; Region: Rossmann-like; pfam10727 446462000828 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446462000829 pantoate--beta-alanine ligase; Region: panC; TIGR00018 446462000830 Pantoate-beta-alanine ligase; Region: PanC; cd00560 446462000831 active site 446462000832 ATP-binding site [chemical binding]; other site 446462000833 pantoate-binding site; other site 446462000834 HXXH motif; other site 446462000835 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446462000836 tetramerization interface [polypeptide binding]; other site 446462000837 active site 446462000838 pantothenate kinase; Reviewed; Region: PRK13318 446462000839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462000840 S-adenosylmethionine binding site [chemical binding]; other site 446462000841 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446462000842 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446462000843 putative anticodon binding site; other site 446462000844 dimer interface [polypeptide binding]; other site 446462000845 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446462000846 motif 1; other site 446462000847 dimer interface [polypeptide binding]; other site 446462000848 active site 446462000849 motif 2; other site 446462000850 motif 3; other site 446462000851 Lsr2; Region: Lsr2; pfam11774 446462000852 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462000853 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462000854 ABC-ATPase subunit interface; other site 446462000855 dimer interface [polypeptide binding]; other site 446462000856 putative PBP binding regions; other site 446462000857 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462000858 ABC-ATPase subunit interface; other site 446462000859 dimer interface [polypeptide binding]; other site 446462000860 putative PBP binding regions; other site 446462000861 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462000862 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462000863 Walker A/P-loop; other site 446462000864 ATP binding site [chemical binding]; other site 446462000865 Q-loop/lid; other site 446462000866 ABC transporter signature motif; other site 446462000867 Walker B; other site 446462000868 D-loop; other site 446462000869 H-loop/switch region; other site 446462000870 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 446462000871 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 446462000872 Clp protease ATP binding subunit; Region: clpC; CHL00095 446462000873 Clp amino terminal domain; Region: Clp_N; pfam02861 446462000874 Clp amino terminal domain; Region: Clp_N; pfam02861 446462000875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462000876 Walker A motif; other site 446462000877 ATP binding site [chemical binding]; other site 446462000878 Walker B motif; other site 446462000879 arginine finger; other site 446462000880 UvrB/uvrC motif; Region: UVR; pfam02151 446462000881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462000882 Walker A motif; other site 446462000883 ATP binding site [chemical binding]; other site 446462000884 Walker B motif; other site 446462000885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446462000886 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 446462000887 putative substrate binding pocket [chemical binding]; other site 446462000888 AC domain interface; other site 446462000889 catalytic triad [active] 446462000890 AB domain interface; other site 446462000891 interchain disulfide; other site 446462000892 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446462000893 putative catalytic site [active] 446462000894 putative phosphate binding site [ion binding]; other site 446462000895 putative metal binding site [ion binding]; other site 446462000896 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446462000897 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 446462000898 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 446462000899 Zn binding site [ion binding]; other site 446462000900 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462000901 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462000902 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 446462000903 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446462000904 endonuclease III; Region: ENDO3c; smart00478 446462000905 minor groove reading motif; other site 446462000906 helix-hairpin-helix signature motif; other site 446462000907 substrate binding pocket [chemical binding]; other site 446462000908 active site 446462000909 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 446462000910 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 446462000911 active site clefts [active] 446462000912 zinc binding site [ion binding]; other site 446462000913 dimer interface [polypeptide binding]; other site 446462000914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462000915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462000916 DNA binding site [nucleotide binding] 446462000917 domain linker motif; other site 446462000918 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 446462000919 putative dimerization interface [polypeptide binding]; other site 446462000920 putative ligand binding site [chemical binding]; other site 446462000921 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462000922 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462000923 DNA binding site [nucleotide binding] 446462000924 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462000925 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462000926 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462000927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462000928 dimer interface [polypeptide binding]; other site 446462000929 conserved gate region; other site 446462000930 putative PBP binding loops; other site 446462000931 ABC-ATPase subunit interface; other site 446462000932 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462000933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462000934 dimer interface [polypeptide binding]; other site 446462000935 conserved gate region; other site 446462000936 putative PBP binding loops; other site 446462000937 ABC-ATPase subunit interface; other site 446462000938 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446462000939 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446462000940 Walker A/P-loop; other site 446462000941 ATP binding site [chemical binding]; other site 446462000942 Q-loop/lid; other site 446462000943 ABC transporter signature motif; other site 446462000944 Walker B; other site 446462000945 D-loop; other site 446462000946 H-loop/switch region; other site 446462000947 TOBE domain; Region: TOBE_2; pfam08402 446462000948 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462000949 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446462000950 intersubunit interface [polypeptide binding]; other site 446462000951 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446462000952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462000953 Walker A/P-loop; other site 446462000954 ATP binding site [chemical binding]; other site 446462000955 Q-loop/lid; other site 446462000956 ABC transporter signature motif; other site 446462000957 Walker B; other site 446462000958 D-loop; other site 446462000959 H-loop/switch region; other site 446462000960 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446462000961 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446462000962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462000963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462000964 metal binding site [ion binding]; metal-binding site 446462000965 active site 446462000966 I-site; other site 446462000967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462000968 putative substrate translocation pore; other site 446462000969 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 446462000970 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446462000971 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446462000972 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446462000973 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 446462000974 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462000975 active site 446462000976 HIGH motif; other site 446462000977 nucleotide binding site [chemical binding]; other site 446462000978 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446462000979 KMSKS motif; other site 446462000980 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446462000981 tRNA binding surface [nucleotide binding]; other site 446462000982 anticodon binding site; other site 446462000983 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446462000984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462000985 motif II; other site 446462000986 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 446462000987 homotrimer interaction site [polypeptide binding]; other site 446462000988 zinc binding site [ion binding]; other site 446462000989 CDP-binding sites; other site 446462000990 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446462000991 substrate binding site; other site 446462000992 dimer interface; other site 446462000993 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 446462000994 Protein of unknown function (DUF461); Region: DUF461; cl01071 446462000995 DNA repair protein RadA; Provisional; Region: PRK11823 446462000996 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446462000997 Walker A motif; other site 446462000998 ATP binding site [chemical binding]; other site 446462000999 Walker B motif; other site 446462001000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462001001 salt bridge; other site 446462001002 non-specific DNA binding site [nucleotide binding]; other site 446462001003 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462001004 sequence-specific DNA binding site [nucleotide binding]; other site 446462001005 short chain dehydrogenase; Provisional; Region: PRK06180 446462001006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462001007 NAD(P) binding site [chemical binding]; other site 446462001008 active site 446462001009 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 446462001010 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 446462001011 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446462001012 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446462001013 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 446462001014 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 446462001015 active site 446462001016 homotetramer interface [polypeptide binding]; other site 446462001017 Uncharacterized conserved protein [Function unknown]; Region: COG2966 446462001018 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 446462001019 Uncharacterized conserved protein [Function unknown]; Region: COG3610 446462001020 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 446462001021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462001022 dimerization interface [polypeptide binding]; other site 446462001023 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462001024 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462001025 dimer interface [polypeptide binding]; other site 446462001026 putative CheW interface [polypeptide binding]; other site 446462001027 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462001028 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462001029 GAF domain; Region: GAF_2; pfam13185 446462001030 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462001031 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462001032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462001033 dimer interface [polypeptide binding]; other site 446462001034 putative CheW interface [polypeptide binding]; other site 446462001035 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446462001036 metal ion-dependent adhesion site (MIDAS); other site 446462001037 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 446462001038 dimerization interface [polypeptide binding]; other site 446462001039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462001040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462001041 dimer interface [polypeptide binding]; other site 446462001042 phosphorylation site [posttranslational modification] 446462001043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462001044 ATP binding site [chemical binding]; other site 446462001045 Mg2+ binding site [ion binding]; other site 446462001046 G-X-G motif; other site 446462001047 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462001048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462001049 active site 446462001050 phosphorylation site [posttranslational modification] 446462001051 intermolecular recognition site; other site 446462001052 dimerization interface [polypeptide binding]; other site 446462001053 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462001054 DNA binding site [nucleotide binding] 446462001055 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 446462001056 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 446462001057 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 446462001058 FAD binding pocket [chemical binding]; other site 446462001059 FAD binding motif [chemical binding]; other site 446462001060 phosphate binding motif [ion binding]; other site 446462001061 beta-alpha-beta structure motif; other site 446462001062 NAD binding pocket [chemical binding]; other site 446462001063 FMN-binding domain; Region: FMN_bind; cl01081 446462001064 ApbE family; Region: ApbE; pfam02424 446462001065 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446462001066 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462001067 DNA binding site [nucleotide binding] 446462001068 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462001069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462001070 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446462001071 active site 446462001072 catalytic triad [active] 446462001073 oxyanion hole [active] 446462001074 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446462001075 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446462001076 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446462001077 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462001078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462001079 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 446462001080 putative dimerization interface [polypeptide binding]; other site 446462001081 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 446462001082 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462001083 active site 446462001084 catalytic residues [active] 446462001085 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462001086 catalytic residues [active] 446462001087 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446462001088 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446462001089 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446462001090 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446462001091 metal binding site [ion binding]; metal-binding site 446462001092 substrate binding pocket [chemical binding]; other site 446462001093 short chain dehydrogenase; Provisional; Region: PRK06138 446462001094 classical (c) SDRs; Region: SDR_c; cd05233 446462001095 NAD(P) binding site [chemical binding]; other site 446462001096 active site 446462001097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462001098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462001099 active site 446462001100 catalytic tetrad [active] 446462001101 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 446462001102 Amidohydrolase; Region: Amidohydro_2; pfam04909 446462001103 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462001104 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462001105 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446462001106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462001107 DNA-binding site [nucleotide binding]; DNA binding site 446462001108 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446462001109 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 446462001110 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446462001111 dimer interface [polypeptide binding]; other site 446462001112 active site 446462001113 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446462001114 dimer interface [polypeptide binding]; other site 446462001115 active site 446462001116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462001117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001118 dimer interface [polypeptide binding]; other site 446462001119 ABC-ATPase subunit interface; other site 446462001120 putative PBP binding loops; other site 446462001121 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446462001122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001123 putative PBP binding loops; other site 446462001124 ABC-ATPase subunit interface; other site 446462001125 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462001126 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462001127 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462001128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462001129 DNA-binding site [nucleotide binding]; DNA binding site 446462001130 UTRA domain; Region: UTRA; pfam07702 446462001131 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 446462001132 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 446462001133 tetramer interface [polypeptide binding]; other site 446462001134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462001135 catalytic residue [active] 446462001136 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 446462001137 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 446462001138 putative active site [active] 446462001139 metal binding site [ion binding]; metal-binding site 446462001140 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 446462001141 thiamine phosphate binding site [chemical binding]; other site 446462001142 active site 446462001143 pyrophosphate binding site [ion binding]; other site 446462001144 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462001145 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 446462001146 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 446462001147 thiS-thiF/thiG interaction site; other site 446462001148 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 446462001149 ThiS interaction site; other site 446462001150 putative active site [active] 446462001151 tetramer interface [polypeptide binding]; other site 446462001152 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462001153 MarR family; Region: MarR; pfam01047 446462001154 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 446462001155 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 446462001156 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462001157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462001158 non-specific DNA binding site [nucleotide binding]; other site 446462001159 salt bridge; other site 446462001160 sequence-specific DNA binding site [nucleotide binding]; other site 446462001161 short chain dehydrogenase; Provisional; Region: PRK06500 446462001162 classical (c) SDRs; Region: SDR_c; cd05233 446462001163 NAD(P) binding site [chemical binding]; other site 446462001164 active site 446462001165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462001166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462001167 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462001168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462001169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462001170 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446462001171 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462001172 putative NAD(P) binding site [chemical binding]; other site 446462001173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462001174 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446462001175 dimer interface [polypeptide binding]; other site 446462001176 substrate binding site [chemical binding]; other site 446462001177 ATP binding site [chemical binding]; other site 446462001178 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 446462001179 ThiC-associated domain; Region: ThiC-associated; pfam13667 446462001180 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 446462001181 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446462001182 active site 446462001183 catalytic residues [active] 446462001184 metal binding site [ion binding]; metal-binding site 446462001185 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 446462001186 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446462001187 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 446462001188 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462001189 DNA-binding site [nucleotide binding]; DNA binding site 446462001190 FCD domain; Region: FCD; cl11656 446462001191 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446462001192 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446462001193 active site 446462001194 FMN binding site [chemical binding]; other site 446462001195 substrate binding site [chemical binding]; other site 446462001196 homotetramer interface [polypeptide binding]; other site 446462001197 catalytic residue [active] 446462001198 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 446462001199 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 446462001200 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 446462001201 Walker A motif; other site 446462001202 ATP binding site [chemical binding]; other site 446462001203 Walker B motif; other site 446462001204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462001205 ATP binding site [chemical binding]; other site 446462001206 Walker B motif; other site 446462001207 arginine finger; other site 446462001208 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446462001209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462001210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462001211 DNA binding residues [nucleotide binding] 446462001212 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446462001213 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 446462001214 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 446462001215 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 446462001216 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446462001217 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446462001218 dimer interface [polypeptide binding]; other site 446462001219 putative functional site; other site 446462001220 putative MPT binding site; other site 446462001221 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446462001222 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446462001223 DNA-binding site [nucleotide binding]; DNA binding site 446462001224 RNA-binding motif; other site 446462001225 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462001226 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462001227 active site 446462001228 ATP binding site [chemical binding]; other site 446462001229 substrate binding site [chemical binding]; other site 446462001230 activation loop (A-loop); other site 446462001231 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446462001232 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446462001233 ring oligomerisation interface [polypeptide binding]; other site 446462001234 ATP/Mg binding site [chemical binding]; other site 446462001235 stacking interactions; other site 446462001236 hinge regions; other site 446462001237 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462001238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462001239 CutC family; Region: CutC; cl01218 446462001240 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462001241 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462001242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001243 dimer interface [polypeptide binding]; other site 446462001244 conserved gate region; other site 446462001245 putative PBP binding loops; other site 446462001246 ABC-ATPase subunit interface; other site 446462001247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462001248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001249 dimer interface [polypeptide binding]; other site 446462001250 conserved gate region; other site 446462001251 putative PBP binding loops; other site 446462001252 ABC-ATPase subunit interface; other site 446462001253 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 446462001254 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446462001255 active site 446462001256 PspC domain; Region: PspC; pfam04024 446462001257 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 446462001258 XdhC Rossmann domain; Region: XdhC_C; pfam13478 446462001259 O-succinylbenzoate synthase; Provisional; Region: PRK02901 446462001260 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 446462001261 active site 446462001262 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446462001263 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446462001264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446462001265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462001266 ATP binding site [chemical binding]; other site 446462001267 putative Mg++ binding site [ion binding]; other site 446462001268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462001269 nucleotide binding region [chemical binding]; other site 446462001270 ATP-binding site [chemical binding]; other site 446462001271 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 446462001272 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 446462001273 Nitrate and nitrite sensing; Region: NIT; pfam08376 446462001274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462001275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462001276 ATP binding site [chemical binding]; other site 446462001277 Mg2+ binding site [ion binding]; other site 446462001278 G-X-G motif; other site 446462001279 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 446462001280 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446462001281 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446462001282 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446462001283 G2 box; other site 446462001284 Switch I region; other site 446462001285 G3 box; other site 446462001286 Switch II region; other site 446462001287 GTP/Mg2+ binding site [chemical binding]; other site 446462001288 G4 box; other site 446462001289 G5 box; other site 446462001290 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446462001291 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446462001292 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446462001293 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446462001294 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 446462001295 putative NAD(P) binding site [chemical binding]; other site 446462001296 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 446462001297 trimer interface [polypeptide binding]; other site 446462001298 dimer interface [polypeptide binding]; other site 446462001299 putative active site [active] 446462001300 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 446462001301 MPT binding site; other site 446462001302 trimer interface [polypeptide binding]; other site 446462001303 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 446462001304 MoaE homodimer interface [polypeptide binding]; other site 446462001305 MoaD interaction [polypeptide binding]; other site 446462001306 active site residues [active] 446462001307 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446462001308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446462001309 Ubiquitin-like proteins; Region: UBQ; cl00155 446462001310 charged pocket; other site 446462001311 hydrophobic patch; other site 446462001312 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 446462001313 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462001314 FeS/SAM binding site; other site 446462001315 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 446462001316 MarR family; Region: MarR; pfam01047 446462001317 UMP phosphatase; Provisional; Region: PRK10444 446462001318 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462001319 active site 446462001320 motif I; other site 446462001321 motif II; other site 446462001322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462001323 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462001324 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462001325 active site 446462001326 metal binding site [ion binding]; metal-binding site 446462001327 hypothetical protein; Provisional; Region: PRK11770 446462001328 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446462001329 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446462001330 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462001331 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462001332 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462001333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462001334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462001335 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446462001336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462001337 motif II; other site 446462001338 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446462001339 DNA-binding site [nucleotide binding]; DNA binding site 446462001340 RNA-binding motif; other site 446462001341 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 446462001342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462001343 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 446462001344 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 446462001345 Protein of unknown function (DUF2530); Region: DUF2530; pfam10745 446462001346 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 446462001347 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462001348 MarR family; Region: MarR; pfam01047 446462001349 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462001350 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462001351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462001352 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446462001353 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446462001354 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446462001355 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446462001356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462001358 ABC transporter signature motif; other site 446462001359 Walker B; other site 446462001360 D-loop; other site 446462001361 H-loop/switch region; other site 446462001362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462001363 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446462001364 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446462001365 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446462001366 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 446462001367 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446462001368 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462001369 enterobactin exporter EntS; Provisional; Region: PRK10489 446462001370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462001371 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 446462001372 substrate binding site [chemical binding]; other site 446462001373 catalytic residues [active] 446462001374 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 446462001375 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446462001376 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446462001377 UreD urease accessory protein; Region: UreD; cl00530 446462001378 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446462001379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446462001380 AAA domain; Region: AAA_18; pfam13238 446462001381 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 446462001382 urease subunit alpha; Reviewed; Region: ureC; PRK13206 446462001383 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 446462001384 subunit interactions [polypeptide binding]; other site 446462001385 active site 446462001386 flap region; other site 446462001387 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 446462001388 alpha-beta subunit interface [polypeptide binding]; other site 446462001389 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 446462001390 alpha-gamma subunit interface [polypeptide binding]; other site 446462001391 beta-gamma subunit interface [polypeptide binding]; other site 446462001392 citrate synthase 2; Provisional; Region: PRK12350 446462001393 Citrate synthase; Region: Citrate_synt; pfam00285 446462001394 oxalacetate binding site [chemical binding]; other site 446462001395 citrylCoA binding site [chemical binding]; other site 446462001396 coenzyme A binding site [chemical binding]; other site 446462001397 catalytic triad [active] 446462001398 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462001399 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446462001400 Walker A/P-loop; other site 446462001401 ATP binding site [chemical binding]; other site 446462001402 Q-loop/lid; other site 446462001403 ABC transporter signature motif; other site 446462001404 Walker B; other site 446462001405 D-loop; other site 446462001406 H-loop/switch region; other site 446462001407 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446462001408 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446462001409 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462001410 Histidine kinase; Region: HisKA_3; pfam07730 446462001411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462001412 ATP binding site [chemical binding]; other site 446462001413 Mg2+ binding site [ion binding]; other site 446462001414 G-X-G motif; other site 446462001415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462001416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462001417 active site 446462001418 phosphorylation site [posttranslational modification] 446462001419 intermolecular recognition site; other site 446462001420 dimerization interface [polypeptide binding]; other site 446462001421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462001422 DNA binding residues [nucleotide binding] 446462001423 dimerization interface [polypeptide binding]; other site 446462001424 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462001425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462001426 catalytic residue [active] 446462001427 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 446462001428 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462001429 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462001430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462001431 Walker A/P-loop; other site 446462001432 ATP binding site [chemical binding]; other site 446462001433 Q-loop/lid; other site 446462001434 ABC transporter signature motif; other site 446462001435 Walker B; other site 446462001436 D-loop; other site 446462001437 H-loop/switch region; other site 446462001438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462001439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462001440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462001441 Walker A/P-loop; other site 446462001442 ATP binding site [chemical binding]; other site 446462001443 Q-loop/lid; other site 446462001444 ABC transporter signature motif; other site 446462001445 Walker B; other site 446462001446 D-loop; other site 446462001447 H-loop/switch region; other site 446462001448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462001449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462001450 amino acid transporter; Region: 2A0306; TIGR00909 446462001451 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 446462001452 active site 446462001453 catalytic residues [active] 446462001454 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446462001455 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 446462001456 active site 446462001457 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462001458 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462001459 active site 446462001460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462001461 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462001462 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 446462001463 putative substrate binding site [chemical binding]; other site 446462001464 putative ATP binding site [chemical binding]; other site 446462001465 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 446462001466 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 446462001467 dimer interface [polypeptide binding]; other site 446462001468 active site 446462001469 citrylCoA binding site [chemical binding]; other site 446462001470 NADH binding [chemical binding]; other site 446462001471 cationic pore residues; other site 446462001472 oxalacetate/citrate binding site [chemical binding]; other site 446462001473 coenzyme A binding site [chemical binding]; other site 446462001474 catalytic triad [active] 446462001475 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 446462001476 DNA photolyase; Region: DNA_photolyase; pfam00875 446462001477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462001478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462001479 active site 446462001480 phosphorylation site [posttranslational modification] 446462001481 intermolecular recognition site; other site 446462001482 dimerization interface [polypeptide binding]; other site 446462001483 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462001484 DNA binding residues [nucleotide binding] 446462001485 dimerization interface [polypeptide binding]; other site 446462001486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462001487 Histidine kinase; Region: HisKA_3; pfam07730 446462001488 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446462001489 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 446462001490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462001491 Walker A/P-loop; other site 446462001492 ATP binding site [chemical binding]; other site 446462001493 Q-loop/lid; other site 446462001494 ABC transporter signature motif; other site 446462001495 Walker B; other site 446462001496 D-loop; other site 446462001497 H-loop/switch region; other site 446462001498 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446462001499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462001500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462001501 non-specific DNA binding site [nucleotide binding]; other site 446462001502 salt bridge; other site 446462001503 sequence-specific DNA binding site [nucleotide binding]; other site 446462001504 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446462001505 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 446462001506 cytosine deaminase; Provisional; Region: PRK05985 446462001507 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 446462001508 active site 446462001509 Prostaglandin dehydrogenases; Region: PGDH; cd05288 446462001510 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 446462001511 NAD(P) binding site [chemical binding]; other site 446462001512 substrate binding site [chemical binding]; other site 446462001513 dimer interface [polypeptide binding]; other site 446462001514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462001515 Coenzyme A binding pocket [chemical binding]; other site 446462001516 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446462001517 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462001518 EspG family; Region: ESX-1_EspG; pfam14011 446462001519 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446462001520 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462001521 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462001522 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462001523 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462001524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446462001525 dimerization interface [polypeptide binding]; other site 446462001526 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 446462001527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462001528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462001529 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446462001530 substrate binding pocket [chemical binding]; other site 446462001531 dimerization interface [polypeptide binding]; other site 446462001532 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446462001533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462001534 NAD(P) binding site [chemical binding]; other site 446462001535 active site 446462001536 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462001537 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446462001538 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 446462001539 putative active site pocket [active] 446462001540 dimerization interface [polypeptide binding]; other site 446462001541 putative catalytic residue [active] 446462001542 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446462001543 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446462001544 G1 box; other site 446462001545 GTP/Mg2+ binding site [chemical binding]; other site 446462001546 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 446462001547 G1 box; other site 446462001548 GTP/Mg2+ binding site [chemical binding]; other site 446462001549 G2 box; other site 446462001550 Switch I region; other site 446462001551 G3 box; other site 446462001552 Switch II region; other site 446462001553 G4 box; other site 446462001554 G5 box; other site 446462001555 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446462001556 nucleotide binding site [chemical binding]; other site 446462001557 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446462001558 SBD interface [polypeptide binding]; other site 446462001559 AAA domain; Region: AAA_22; pfam13401 446462001560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462001561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462001562 DNA binding residues [nucleotide binding] 446462001563 dimerization interface [polypeptide binding]; other site 446462001564 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 446462001565 AAA ATPase domain; Region: AAA_16; pfam13191 446462001566 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446462001567 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 446462001568 structural tetrad; other site 446462001569 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 446462001570 structural tetrad; other site 446462001571 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446462001572 WD domain, G-beta repeat; Region: WD40; pfam00400 446462001573 Helix-turn-helix domain; Region: HTH_18; pfam12833 446462001574 AlkA N-terminal domain; Region: AlkA_N; pfam06029 446462001575 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446462001576 Leucine carboxyl methyltransferase; Region: LCM; cl01306 446462001577 Helix-turn-helix domain; Region: HTH_31; pfam13560 446462001578 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462001579 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446462001580 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446462001581 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462001582 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462001583 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462001584 Cna protein B-type domain; Region: Cna_B; pfam05738 446462001585 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446462001586 RHS Repeat; Region: RHS_repeat; pfam05593 446462001587 RHS Repeat; Region: RHS_repeat; pfam05593 446462001588 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446462001589 RHS Repeat; Region: RHS_repeat; pfam05593 446462001590 RHS Repeat; Region: RHS_repeat; cl11982 446462001591 RHS Repeat; Region: RHS_repeat; pfam05593 446462001592 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 446462001593 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446462001594 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 446462001595 nudix motif; other site 446462001596 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462001597 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462001598 NB-ARC domain; Region: NB-ARC; pfam00931 446462001599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462001600 TPR motif; other site 446462001601 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462001602 binding surface 446462001603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462001604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462001605 TPR motif; other site 446462001606 binding surface 446462001607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462001608 TPR repeat; Region: TPR_11; pfam13414 446462001609 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 446462001610 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462001611 DDE superfamily endonuclease; Region: DDE_4; pfam13359 446462001612 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 446462001613 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462001614 DDE superfamily endonuclease; Region: DDE_4; pfam13359 446462001615 DNA-sulfur modification-associated; Region: DndB; cl17621 446462001616 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446462001617 Active Sites [active] 446462001618 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 446462001619 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 446462001620 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 446462001621 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462001622 catalytic residue [active] 446462001623 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 446462001624 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446462001625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446462001626 ATP binding site [chemical binding]; other site 446462001627 putative Mg++ binding site [ion binding]; other site 446462001628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462001629 nucleotide binding region [chemical binding]; other site 446462001630 ATP-binding site [chemical binding]; other site 446462001631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462001632 ATP binding site [chemical binding]; other site 446462001633 Mg2+ binding site [ion binding]; other site 446462001634 G-X-G motif; other site 446462001635 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 446462001636 PLD-like domain; Region: PLDc_2; pfam13091 446462001637 putative homodimer interface [polypeptide binding]; other site 446462001638 putative active site [active] 446462001639 catalytic site [active] 446462001640 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446462001641 DNA binding site [nucleotide binding] 446462001642 active site 446462001643 Int/Topo IB signature motif; other site 446462001644 catalytic residues [active] 446462001645 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446462001646 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446462001647 active site 446462001648 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462001649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462001650 active site 446462001651 phosphorylation site [posttranslational modification] 446462001652 intermolecular recognition site; other site 446462001653 dimerization interface [polypeptide binding]; other site 446462001654 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462001655 dimerization interface [polypeptide binding]; other site 446462001656 DNA binding residues [nucleotide binding] 446462001657 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462001658 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462001659 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462001660 metal binding site [ion binding]; metal-binding site 446462001661 active site 446462001662 I-site; other site 446462001663 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 446462001664 putative FMN binding site [chemical binding]; other site 446462001665 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 446462001666 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 446462001667 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 446462001668 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446462001669 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462001670 catalytic core [active] 446462001671 EthD domain; Region: EthD; cl17553 446462001672 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446462001673 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462001674 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462001675 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 446462001676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462001677 Coenzyme A binding pocket [chemical binding]; other site 446462001678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462001679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462001680 active site 446462001681 phosphorylation site [posttranslational modification] 446462001682 intermolecular recognition site; other site 446462001683 dimerization interface [polypeptide binding]; other site 446462001684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462001685 DNA binding site [nucleotide binding] 446462001686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462001687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462001688 dimerization interface [polypeptide binding]; other site 446462001689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462001690 dimer interface [polypeptide binding]; other site 446462001691 phosphorylation site [posttranslational modification] 446462001692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462001693 ATP binding site [chemical binding]; other site 446462001694 Mg2+ binding site [ion binding]; other site 446462001695 G-X-G motif; other site 446462001696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462001697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001698 conserved gate region; other site 446462001699 putative PBP binding loops; other site 446462001700 ABC-ATPase subunit interface; other site 446462001701 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446462001702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001703 dimer interface [polypeptide binding]; other site 446462001704 conserved gate region; other site 446462001705 ABC-ATPase subunit interface; other site 446462001706 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462001707 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462001708 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446462001709 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446462001710 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446462001711 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462001712 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446462001713 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446462001714 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 446462001715 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 446462001716 dimer interface [polypeptide binding]; other site 446462001717 active site 446462001718 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446462001719 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446462001720 protein binding site [polypeptide binding]; other site 446462001721 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 446462001722 MPT binding site; other site 446462001723 trimer interface [polypeptide binding]; other site 446462001724 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 446462001725 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 446462001726 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 446462001727 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 446462001728 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 446462001729 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 446462001730 active site 446462001731 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446462001732 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446462001733 dimer interface [polypeptide binding]; other site 446462001734 putative functional site; other site 446462001735 putative MPT binding site; other site 446462001736 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446462001737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462001738 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462001739 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462001740 ligand binding site [chemical binding]; other site 446462001741 flexible hinge region; other site 446462001742 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 446462001743 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446462001744 Part of AAA domain; Region: AAA_19; pfam13245 446462001745 Family description; Region: UvrD_C_2; pfam13538 446462001746 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462001747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462001748 active site 446462001749 ATP binding site [chemical binding]; other site 446462001750 substrate binding site [chemical binding]; other site 446462001751 activation loop (A-loop); other site 446462001752 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 446462001753 Predicted methyltransferases [General function prediction only]; Region: COG0313 446462001754 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 446462001755 putative SAM binding site [chemical binding]; other site 446462001756 putative homodimer interface [polypeptide binding]; other site 446462001757 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 446462001758 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 446462001759 active site 446462001760 HIGH motif; other site 446462001761 KMSKS motif; other site 446462001762 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446462001763 tRNA binding surface [nucleotide binding]; other site 446462001764 anticodon binding site; other site 446462001765 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 446462001766 active site 446462001767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 446462001768 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446462001769 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446462001770 Domain of unknown function (DUF348); Region: DUF348; pfam03990 446462001771 G5 domain; Region: G5; pfam07501 446462001772 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 446462001773 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 446462001774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462001775 S-adenosylmethionine binding site [chemical binding]; other site 446462001776 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 446462001777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462001778 Walker A/P-loop; other site 446462001779 ATP binding site [chemical binding]; other site 446462001780 Q-loop/lid; other site 446462001781 ABC transporter signature motif; other site 446462001782 Walker B; other site 446462001783 D-loop; other site 446462001784 H-loop/switch region; other site 446462001785 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 446462001786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001787 dimer interface [polypeptide binding]; other site 446462001788 conserved gate region; other site 446462001789 ABC-ATPase subunit interface; other site 446462001790 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 446462001791 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 446462001792 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 446462001793 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446462001794 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446462001795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462001796 ABC transporter; Region: ABC_tran_2; pfam12848 446462001797 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462001798 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462001799 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 446462001800 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462001801 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462001802 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462001803 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462001804 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 446462001805 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462001806 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 446462001807 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 446462001808 acyl-activating enzyme (AAE) consensus motif; other site 446462001809 active site 446462001810 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 446462001811 putative active site [active] 446462001812 catalytic residue [active] 446462001813 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462001814 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 446462001815 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 446462001816 5S rRNA interface [nucleotide binding]; other site 446462001817 CTC domain interface [polypeptide binding]; other site 446462001818 L16 interface [polypeptide binding]; other site 446462001819 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 446462001820 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 446462001821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462001822 active site 446462001823 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 446462001824 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 446462001825 Substrate binding site; other site 446462001826 Mg++ binding site; other site 446462001827 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 446462001828 active site 446462001829 substrate binding site [chemical binding]; other site 446462001830 CoA binding site [chemical binding]; other site 446462001831 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462001832 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462001833 metal binding site [ion binding]; metal-binding site 446462001834 active site 446462001835 I-site; other site 446462001836 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462001837 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462001838 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 446462001839 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446462001840 Di-iron ligands [ion binding]; other site 446462001841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462001842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462001843 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 446462001844 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446462001845 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446462001846 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 446462001847 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 446462001848 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462001849 ATP binding site [chemical binding]; other site 446462001850 putative Mg++ binding site [ion binding]; other site 446462001851 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462001852 nucleotide binding region [chemical binding]; other site 446462001853 ATP-binding site [chemical binding]; other site 446462001854 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 446462001855 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 446462001856 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 446462001857 homodimer interface [polypeptide binding]; other site 446462001858 metal binding site [ion binding]; metal-binding site 446462001859 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 446462001860 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446462001861 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 446462001862 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 446462001863 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 446462001864 Domain interface; other site 446462001865 Peptide binding site; other site 446462001866 Active site tetrad [active] 446462001867 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446462001868 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446462001869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462001870 TPR motif; other site 446462001871 TPR repeat; Region: TPR_11; pfam13414 446462001872 binding surface 446462001873 enolase; Provisional; Region: eno; PRK00077 446462001874 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446462001875 dimer interface [polypeptide binding]; other site 446462001876 metal binding site [ion binding]; metal-binding site 446462001877 substrate binding pocket [chemical binding]; other site 446462001878 Septum formation initiator; Region: DivIC; pfam04977 446462001879 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 446462001880 Uncharacterized conserved protein [Function unknown]; Region: COG1507 446462001881 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446462001882 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446462001883 catalytic residue [active] 446462001884 exopolyphosphatase; Region: exo_poly_only; TIGR03706 446462001885 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446462001886 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446462001887 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462001888 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462001889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001890 dimer interface [polypeptide binding]; other site 446462001891 conserved gate region; other site 446462001892 putative PBP binding loops; other site 446462001893 ABC-ATPase subunit interface; other site 446462001894 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446462001895 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462001896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462001897 dimer interface [polypeptide binding]; other site 446462001898 conserved gate region; other site 446462001899 putative PBP binding loops; other site 446462001900 ABC-ATPase subunit interface; other site 446462001901 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446462001902 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462001903 Walker A/P-loop; other site 446462001904 ATP binding site [chemical binding]; other site 446462001905 Q-loop/lid; other site 446462001906 ABC transporter signature motif; other site 446462001907 Walker B; other site 446462001908 D-loop; other site 446462001909 H-loop/switch region; other site 446462001910 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446462001911 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 446462001912 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462001913 Walker A/P-loop; other site 446462001914 ATP binding site [chemical binding]; other site 446462001915 Q-loop/lid; other site 446462001916 ABC transporter signature motif; other site 446462001917 Walker B; other site 446462001918 D-loop; other site 446462001919 H-loop/switch region; other site 446462001920 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446462001921 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 446462001922 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 446462001923 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 446462001924 Fe-S cluster binding site [ion binding]; other site 446462001925 DNA binding site [nucleotide binding] 446462001926 active site 446462001927 MoxR-like ATPases [General function prediction only]; Region: COG0714 446462001928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462001929 ATP binding site [chemical binding]; other site 446462001930 Walker A motif; other site 446462001931 Walker B motif; other site 446462001932 arginine finger; other site 446462001933 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446462001934 Protein of unknown function DUF58; Region: DUF58; pfam01882 446462001935 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446462001936 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462001937 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 446462001938 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 446462001939 putative FMN binding site [chemical binding]; other site 446462001940 NADPH bind site [chemical binding]; other site 446462001941 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446462001942 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 446462001943 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 446462001944 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 446462001945 active site 446462001946 putative catalytic site [active] 446462001947 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 446462001948 Bax inhibitor 1 like; Region: BaxI_1; cl17691 446462001949 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 446462001950 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446462001951 dimer interface [polypeptide binding]; other site 446462001952 active site 446462001953 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 446462001954 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446462001955 dimer interface [polypeptide binding]; other site 446462001956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462001957 catalytic residue [active] 446462001958 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 446462001959 RDD family; Region: RDD; pfam06271 446462001960 cystathionine gamma-synthase; Provisional; Region: PRK07811 446462001961 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446462001962 homodimer interface [polypeptide binding]; other site 446462001963 substrate-cofactor binding pocket; other site 446462001964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462001965 catalytic residue [active] 446462001966 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 446462001967 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 446462001968 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 446462001969 dimer interface [polypeptide binding]; other site 446462001970 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 446462001971 active site 446462001972 Fe binding site [ion binding]; other site 446462001973 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462001974 AsnC family; Region: AsnC_trans_reg; pfam01037 446462001975 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446462001976 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 446462001977 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446462001978 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 446462001979 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 446462001980 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 446462001981 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 446462001982 catalytic residues [active] 446462001983 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 446462001984 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 446462001985 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446462001986 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446462001987 catalytic residue [active] 446462001988 putative FPP diphosphate binding site; other site 446462001989 putative FPP binding hydrophobic cleft; other site 446462001990 dimer interface [polypeptide binding]; other site 446462001991 putative IPP diphosphate binding site; other site 446462001992 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 446462001993 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 446462001994 putative active site [active] 446462001995 PhoH-like protein; Region: PhoH; pfam02562 446462001996 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 446462001997 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 446462001998 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446462001999 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446462002000 active site 446462002001 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 446462002002 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 446462002003 active site 446462002004 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 446462002005 DNA binding site [nucleotide binding] 446462002006 fumarate hydratase; Reviewed; Region: fumC; PRK00485 446462002007 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446462002008 tetramer interface [polypeptide binding]; other site 446462002009 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446462002010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462002011 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462002012 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446462002013 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446462002014 cleavage site 446462002015 active site 446462002016 substrate binding sites [chemical binding]; other site 446462002017 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 446462002018 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 446462002019 putative active site [active] 446462002020 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 446462002021 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 446462002022 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 446462002023 generic binding surface II; other site 446462002024 generic binding surface I; other site 446462002025 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 446462002026 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446462002027 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446462002028 RmuC family; Region: RmuC; pfam02646 446462002029 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 446462002030 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462002031 active site 446462002032 metal binding site [ion binding]; metal-binding site 446462002033 DNA binding site [nucleotide binding] 446462002034 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 446462002035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462002036 Walker A/P-loop; other site 446462002037 ATP binding site [chemical binding]; other site 446462002038 Q-loop/lid; other site 446462002039 ABC transporter signature motif; other site 446462002040 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 446462002041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462002042 ABC transporter signature motif; other site 446462002043 Walker B; other site 446462002044 D-loop; other site 446462002045 H-loop/switch region; other site 446462002046 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 446462002047 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446462002048 DNA binding site [nucleotide binding] 446462002049 active site 446462002050 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 446462002051 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 446462002052 AlkA N-terminal domain; Region: AlkA_N; pfam06029 446462002053 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 446462002054 GTP-binding protein YchF; Reviewed; Region: PRK09601 446462002055 YchF GTPase; Region: YchF; cd01900 446462002056 G1 box; other site 446462002057 GTP/Mg2+ binding site [chemical binding]; other site 446462002058 Switch I region; other site 446462002059 G2 box; other site 446462002060 Switch II region; other site 446462002061 G3 box; other site 446462002062 G4 box; other site 446462002063 G5 box; other site 446462002064 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 446462002065 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 446462002066 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446462002067 mannosyltransferase; Provisional; Region: pimE; PRK13375 446462002068 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 446462002069 aromatic arch; other site 446462002070 DCoH dimer interaction site [polypeptide binding]; other site 446462002071 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446462002072 DCoH tetramer interaction site [polypeptide binding]; other site 446462002073 substrate binding site [chemical binding]; other site 446462002074 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 446462002075 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446462002076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462002077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462002078 ABC-ATPase subunit interface; other site 446462002079 putative PBP binding loops; other site 446462002080 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446462002081 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 446462002082 Walker A/P-loop; other site 446462002083 ATP binding site [chemical binding]; other site 446462002084 Q-loop/lid; other site 446462002085 ABC transporter signature motif; other site 446462002086 Walker B; other site 446462002087 D-loop; other site 446462002088 H-loop/switch region; other site 446462002089 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446462002090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462002091 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462002092 Walker A/P-loop; other site 446462002093 ATP binding site [chemical binding]; other site 446462002094 Q-loop/lid; other site 446462002095 ABC transporter signature motif; other site 446462002096 Walker B; other site 446462002097 D-loop; other site 446462002098 H-loop/switch region; other site 446462002099 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 446462002100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462002101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462002102 active site 446462002103 phosphorylation site [posttranslational modification] 446462002104 intermolecular recognition site; other site 446462002105 dimerization interface [polypeptide binding]; other site 446462002106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462002107 DNA binding site [nucleotide binding] 446462002108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462002109 dimer interface [polypeptide binding]; other site 446462002110 phosphorylation site [posttranslational modification] 446462002111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462002112 Mg2+ binding site [ion binding]; other site 446462002113 G-X-G motif; other site 446462002114 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446462002115 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 446462002116 active site 446462002117 8-oxo-dGMP binding site [chemical binding]; other site 446462002118 nudix motif; other site 446462002119 metal binding site [ion binding]; metal-binding site 446462002120 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446462002121 active site 446462002122 HIGH motif; other site 446462002123 dimer interface [polypeptide binding]; other site 446462002124 KMSKS motif; other site 446462002125 YCII-related domain; Region: YCII; cl00999 446462002126 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 446462002127 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 446462002128 G1 box; other site 446462002129 putative GEF interaction site [polypeptide binding]; other site 446462002130 GTP/Mg2+ binding site [chemical binding]; other site 446462002131 Switch I region; other site 446462002132 G2 box; other site 446462002133 G3 box; other site 446462002134 Switch II region; other site 446462002135 G4 box; other site 446462002136 G5 box; other site 446462002137 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 446462002138 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 446462002139 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446462002140 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462002141 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446462002142 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462002143 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462002144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462002145 putative PBP binding loops; other site 446462002146 dimer interface [polypeptide binding]; other site 446462002147 ABC-ATPase subunit interface; other site 446462002148 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462002149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462002150 dimer interface [polypeptide binding]; other site 446462002151 conserved gate region; other site 446462002152 putative PBP binding loops; other site 446462002153 ABC-ATPase subunit interface; other site 446462002154 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446462002155 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462002156 Walker A/P-loop; other site 446462002157 ATP binding site [chemical binding]; other site 446462002158 Q-loop/lid; other site 446462002159 ABC transporter signature motif; other site 446462002160 Walker B; other site 446462002161 D-loop; other site 446462002162 H-loop/switch region; other site 446462002163 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462002164 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 446462002165 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462002166 Walker A/P-loop; other site 446462002167 ATP binding site [chemical binding]; other site 446462002168 Q-loop/lid; other site 446462002169 ABC transporter signature motif; other site 446462002170 Walker B; other site 446462002171 D-loop; other site 446462002172 H-loop/switch region; other site 446462002173 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446462002174 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 446462002175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462002176 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446462002177 Coenzyme A binding pocket [chemical binding]; other site 446462002178 Ferredoxin [Energy production and conversion]; Region: COG1146 446462002179 4Fe-4S binding domain; Region: Fer4; pfam00037 446462002180 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 446462002181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462002182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462002183 homodimer interface [polypeptide binding]; other site 446462002184 catalytic residue [active] 446462002185 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 446462002186 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 446462002187 putative trimer interface [polypeptide binding]; other site 446462002188 putative CoA binding site [chemical binding]; other site 446462002189 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 446462002190 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 446462002191 metal binding site [ion binding]; metal-binding site 446462002192 putative dimer interface [polypeptide binding]; other site 446462002193 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 446462002194 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 446462002195 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 446462002196 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 446462002197 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 446462002198 dihydropteroate synthase; Region: DHPS; TIGR01496 446462002199 substrate binding pocket [chemical binding]; other site 446462002200 dimer interface [polypeptide binding]; other site 446462002201 inhibitor binding site; inhibition site 446462002202 Predicted transcriptional regulators [Transcription]; Region: COG1695 446462002203 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446462002204 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462002205 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 446462002206 hydrophobic ligand binding site; other site 446462002207 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 446462002208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462002209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462002210 WHG domain; Region: WHG; pfam13305 446462002211 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 446462002212 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462002213 putative NAD(P) binding site [chemical binding]; other site 446462002214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462002215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462002216 WHG domain; Region: WHG; pfam13305 446462002217 enoyl-CoA hydratase; Provisional; Region: PRK08140 446462002218 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462002219 substrate binding site [chemical binding]; other site 446462002220 oxyanion hole (OAH) forming residues; other site 446462002221 trimer interface [polypeptide binding]; other site 446462002222 PaaX-like protein; Region: PaaX; pfam07848 446462002223 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 446462002224 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 446462002225 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 446462002226 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446462002227 interface (dimer of trimers) [polypeptide binding]; other site 446462002228 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446462002229 Substrate-binding/catalytic site; other site 446462002230 Zn-binding sites [ion binding]; other site 446462002231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462002232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462002233 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 446462002234 putative dimerization interface [polypeptide binding]; other site 446462002235 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462002236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462002237 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 446462002238 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462002239 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 446462002240 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 446462002241 ligand binding site; other site 446462002242 oligomer interface; other site 446462002243 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 446462002244 dimer interface [polypeptide binding]; other site 446462002245 N-terminal domain interface [polypeptide binding]; other site 446462002246 sulfate 1 binding site; other site 446462002247 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 446462002248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462002249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462002250 DNA binding residues [nucleotide binding] 446462002251 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446462002252 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446462002253 sec-independent translocase; Provisional; Region: PRK03100 446462002254 Domain of unknown function DUF59; Region: DUF59; cl00941 446462002255 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 446462002256 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 446462002257 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462002258 MarR family; Region: MarR; pfam01047 446462002259 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 446462002260 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 446462002261 PRC-barrel domain; Region: PRC; pfam05239 446462002262 MgtE intracellular N domain; Region: MgtE_N; smart00924 446462002263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446462002264 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 446462002265 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 446462002266 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462002267 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462002268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462002269 dimer interface [polypeptide binding]; other site 446462002270 conserved gate region; other site 446462002271 putative PBP binding loops; other site 446462002272 ABC-ATPase subunit interface; other site 446462002273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462002274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462002275 dimer interface [polypeptide binding]; other site 446462002276 conserved gate region; other site 446462002277 ABC-ATPase subunit interface; other site 446462002278 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446462002279 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446462002280 Walker A/P-loop; other site 446462002281 ATP binding site [chemical binding]; other site 446462002282 Q-loop/lid; other site 446462002283 ABC transporter signature motif; other site 446462002284 Walker B; other site 446462002285 D-loop; other site 446462002286 H-loop/switch region; other site 446462002287 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446462002288 classical (c) SDRs; Region: SDR_c; cd05233 446462002289 NAD(P) binding site [chemical binding]; other site 446462002290 active site 446462002291 Predicted transcriptional regulators [Transcription]; Region: COG1695 446462002292 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446462002293 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 446462002294 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446462002295 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446462002296 oligomer interface [polypeptide binding]; other site 446462002297 metal binding site [ion binding]; metal-binding site 446462002298 metal binding site [ion binding]; metal-binding site 446462002299 putative Cl binding site [ion binding]; other site 446462002300 basic sphincter; other site 446462002301 hydrophobic gate; other site 446462002302 periplasmic entrance; other site 446462002303 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 446462002304 Bacterial PH domain; Region: DUF304; pfam03703 446462002305 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 446462002306 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 446462002307 active site 446462002308 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 446462002309 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446462002310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462002311 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446462002312 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446462002313 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446462002314 ATP binding site [chemical binding]; other site 446462002315 Mg++ binding site [ion binding]; other site 446462002316 motif III; other site 446462002317 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462002318 nucleotide binding region [chemical binding]; other site 446462002319 ATP-binding site [chemical binding]; other site 446462002320 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794 446462002321 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 446462002322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462002323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462002324 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 446462002325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462002326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462002327 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462002328 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462002329 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446462002330 catalytic site [active] 446462002331 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 446462002332 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 446462002333 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 446462002334 ATP binding site [chemical binding]; other site 446462002335 substrate interface [chemical binding]; other site 446462002336 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446462002337 active site residue [active] 446462002338 TIGR02569 family protein; Region: TIGR02569_actnb 446462002339 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 446462002340 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 446462002341 [4Fe-4S] binding site [ion binding]; other site 446462002342 molybdopterin cofactor binding site; other site 446462002343 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 446462002344 molybdopterin cofactor binding site; other site 446462002345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446462002346 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446462002347 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 446462002348 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446462002349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462002350 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446462002351 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446462002352 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446462002353 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446462002354 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 446462002355 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446462002356 active site 446462002357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 446462002358 DNA binding site [nucleotide binding] 446462002359 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446462002360 putative active site [active] 446462002361 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 446462002362 active site 446462002363 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462002364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462002365 active site 446462002366 phosphorylation site [posttranslational modification] 446462002367 intermolecular recognition site; other site 446462002368 dimerization interface [polypeptide binding]; other site 446462002369 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462002370 DNA binding site [nucleotide binding] 446462002371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462002372 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 446462002373 dimerization interface [polypeptide binding]; other site 446462002374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462002375 dimer interface [polypeptide binding]; other site 446462002376 phosphorylation site [posttranslational modification] 446462002377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462002378 ATP binding site [chemical binding]; other site 446462002379 Mg2+ binding site [ion binding]; other site 446462002380 G-X-G motif; other site 446462002381 Ion channel; Region: Ion_trans_2; pfam07885 446462002382 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 446462002383 TrkA-N domain; Region: TrkA_N; pfam02254 446462002384 hypothetical protein; Provisional; Region: PRK08201 446462002385 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 446462002386 metal binding site [ion binding]; metal-binding site 446462002387 putative dimer interface [polypeptide binding]; other site 446462002388 Predicted membrane protein [Function unknown]; Region: COG4270 446462002389 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446462002390 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446462002391 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446462002392 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446462002393 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446462002394 DNA binding site [nucleotide binding] 446462002395 active site 446462002396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446462002397 binding surface 446462002398 TPR motif; other site 446462002399 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446462002400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462002401 NAD(P) binding site [chemical binding]; other site 446462002402 active site 446462002403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462002404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462002405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462002406 dimerization interface [polypeptide binding]; other site 446462002407 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446462002408 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446462002409 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 446462002410 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 446462002411 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 446462002412 IHF dimer interface [polypeptide binding]; other site 446462002413 IHF - DNA interface [nucleotide binding]; other site 446462002414 CGNR zinc finger; Region: zf-CGNR; pfam11706 446462002415 haloalkane dehalogenase; Provisional; Region: PRK03592 446462002416 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462002417 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446462002418 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446462002419 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446462002420 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446462002421 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446462002422 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 446462002423 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 446462002424 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 446462002425 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 446462002426 putative NADH binding site [chemical binding]; other site 446462002427 putative active site [active] 446462002428 nudix motif; other site 446462002429 putative metal binding site [ion binding]; other site 446462002430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462002431 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462002432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462002433 Amidohydrolase; Region: Amidohydro_5; pfam13594 446462002434 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462002435 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 446462002436 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 446462002437 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 446462002438 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 446462002439 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446462002440 Fructosamine kinase; Region: Fructosamin_kin; cl17579 446462002441 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446462002442 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446462002443 active site 446462002444 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446462002445 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446462002446 active site 446462002447 hypothetical protein; Provisional; Region: PRK07908 446462002448 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462002449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462002450 catalytic residue [active] 446462002451 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 446462002452 Uncharacterized conserved protein [Function unknown]; Region: COG0327 446462002453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 446462002454 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 446462002455 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 446462002456 Putative zinc ribbon domain; Region: DUF164; pfam02591 446462002457 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 446462002458 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 446462002459 RNA/DNA hybrid binding site [nucleotide binding]; other site 446462002460 active site 446462002461 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462002462 catalytic core [active] 446462002463 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446462002464 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446462002465 AAA-like domain; Region: AAA_10; pfam12846 446462002466 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446462002467 NlpC/P60 family; Region: NLPC_P60; pfam00877 446462002468 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446462002469 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446462002470 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446462002471 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462002472 intersubunit interface [polypeptide binding]; other site 446462002473 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 446462002474 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446462002475 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462002476 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462002477 Predicted ATPase [General function prediction only]; Region: COG3910 446462002478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 446462002479 Walker A/P-loop; other site 446462002480 ATP binding site [chemical binding]; other site 446462002481 Q-loop/lid; other site 446462002482 ABC transporter signature motif; other site 446462002483 Walker B; other site 446462002484 D-loop; other site 446462002485 H-loop/switch region; other site 446462002486 Predicted ATPase [General function prediction only]; Region: COG3910 446462002487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462002488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 446462002489 Walker A/P-loop; other site 446462002490 Walker A/P-loop; other site 446462002491 ATP binding site [chemical binding]; other site 446462002492 ATP binding site [chemical binding]; other site 446462002493 Q-loop/lid; other site 446462002494 ABC transporter signature motif; other site 446462002495 Walker B; other site 446462002496 D-loop; other site 446462002497 H-loop/switch region; other site 446462002498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462002499 Radical SAM superfamily; Region: Radical_SAM; pfam04055 446462002500 FeS/SAM binding site; other site 446462002501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462002502 non-specific DNA binding site [nucleotide binding]; other site 446462002503 salt bridge; other site 446462002504 sequence-specific DNA binding site [nucleotide binding]; other site 446462002505 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462002506 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 446462002507 oligomerization interface [polypeptide binding]; other site 446462002508 active site 446462002509 metal binding site [ion binding]; metal-binding site 446462002510 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462002511 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446462002512 catalytic site [active] 446462002513 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 446462002514 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446462002515 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446462002516 dimer interface [polypeptide binding]; other site 446462002517 putative anticodon binding site; other site 446462002518 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446462002519 motif 1; other site 446462002520 dimer interface [polypeptide binding]; other site 446462002521 active site 446462002522 motif 2; other site 446462002523 motif 3; other site 446462002524 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462002525 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462002526 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462002527 NAD synthetase; Provisional; Region: PRK13981 446462002528 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446462002529 multimer interface [polypeptide binding]; other site 446462002530 active site 446462002531 catalytic triad [active] 446462002532 protein interface 1 [polypeptide binding]; other site 446462002533 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 446462002534 homodimer interface [polypeptide binding]; other site 446462002535 NAD binding pocket [chemical binding]; other site 446462002536 ATP binding pocket [chemical binding]; other site 446462002537 Mg binding site [ion binding]; other site 446462002538 active-site loop [active] 446462002539 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446462002540 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446462002541 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446462002542 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462002543 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 446462002544 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 446462002545 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 446462002546 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446462002547 metal binding triad; other site 446462002548 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446462002549 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446462002550 metal binding triad; other site 446462002551 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446462002552 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446462002553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462002554 motif II; other site 446462002555 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462002556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462002557 DNA-binding site [nucleotide binding]; DNA binding site 446462002558 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 446462002559 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446462002560 Helix-turn-helix domain; Region: HTH_17; pfam12728 446462002561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462002562 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 446462002563 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462002564 active site 446462002565 DNA binding site [nucleotide binding] 446462002566 Int/Topo IB signature motif; other site 446462002567 glutamine synthetase, type I; Region: GlnA; TIGR00653 446462002568 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446462002569 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446462002570 RDD family; Region: RDD; pfam06271 446462002571 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 446462002572 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446462002573 Part of AAA domain; Region: AAA_19; pfam13245 446462002574 Family description; Region: UvrD_C_2; pfam13538 446462002575 HRDC domain; Region: HRDC; pfam00570 446462002576 Transcription factor WhiB; Region: Whib; pfam02467 446462002577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462002578 S-adenosylmethionine binding site [chemical binding]; other site 446462002579 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 446462002580 ABC1 family; Region: ABC1; pfam03109 446462002581 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446462002582 active site 446462002583 ATP binding site [chemical binding]; other site 446462002584 Protein of unknown function DUF45; Region: DUF45; cl00636 446462002585 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446462002586 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 446462002587 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 446462002588 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446462002589 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 446462002590 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 446462002591 hypothetical protein; Validated; Region: PRK00068 446462002592 peptide chain release factor 2; Validated; Region: prfB; PRK00578 446462002593 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446462002594 RF-1 domain; Region: RF-1; pfam00472 446462002595 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 446462002596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462002597 Walker A/P-loop; other site 446462002598 ATP binding site [chemical binding]; other site 446462002599 Q-loop/lid; other site 446462002600 ABC transporter signature motif; other site 446462002601 Walker B; other site 446462002602 D-loop; other site 446462002603 H-loop/switch region; other site 446462002604 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 446462002605 FtsX-like permease family; Region: FtsX; pfam02687 446462002606 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 446462002607 SmpB-tmRNA interface; other site 446462002608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462002609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462002610 active site 446462002611 phosphorylation site [posttranslational modification] 446462002612 intermolecular recognition site; other site 446462002613 dimerization interface [polypeptide binding]; other site 446462002614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462002615 DNA binding residues [nucleotide binding] 446462002616 Putative sensor; Region: Sensor; pfam13796 446462002617 Histidine kinase; Region: HisKA_3; pfam07730 446462002618 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 446462002619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462002620 ATP binding site [chemical binding]; other site 446462002621 putative Mg++ binding site [ion binding]; other site 446462002622 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462002623 nucleotide binding region [chemical binding]; other site 446462002624 ATP-binding site [chemical binding]; other site 446462002625 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 446462002626 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 446462002627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446462002628 active site 446462002629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462002630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462002631 putative substrate translocation pore; other site 446462002632 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 446462002633 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446462002634 catalytic residues [active] 446462002635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462002636 acyl-activating enzyme (AAE) consensus motif; other site 446462002637 AMP binding site [chemical binding]; other site 446462002638 active site 446462002639 CoA binding site [chemical binding]; other site 446462002640 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462002641 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462002642 active site 446462002643 ATP binding site [chemical binding]; other site 446462002644 substrate binding site [chemical binding]; other site 446462002645 activation loop (A-loop); other site 446462002646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462002647 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 446462002648 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 446462002649 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 446462002650 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 446462002651 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 446462002652 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 446462002653 HsdM N-terminal domain; Region: HsdM_N; pfam12161 446462002654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462002655 S-adenosylmethionine binding site [chemical binding]; other site 446462002656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462002657 S-adenosylmethionine binding site [chemical binding]; other site 446462002658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462002659 DDE superfamily endonuclease; Region: DDE_4; cl17710 446462002660 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462002661 B12 binding domain; Region: B12-binding_2; pfam02607 446462002662 B12 binding domain; Region: B12-binding; pfam02310 446462002663 B12 binding site [chemical binding]; other site 446462002664 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462002665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446462002666 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462002667 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462002668 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446462002669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462002670 putative PBP binding loops; other site 446462002671 ABC-ATPase subunit interface; other site 446462002672 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462002673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462002674 dimer interface [polypeptide binding]; other site 446462002675 conserved gate region; other site 446462002676 putative PBP binding loops; other site 446462002677 ABC-ATPase subunit interface; other site 446462002678 Domain of unknown function (DUF718); Region: DUF718; pfam05336 446462002679 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462002680 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462002681 DNA binding site [nucleotide binding] 446462002682 domain linker motif; other site 446462002683 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462002684 ligand binding site [chemical binding]; other site 446462002685 dimerization interface [polypeptide binding]; other site 446462002686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462002687 sequence-specific DNA binding site [nucleotide binding]; other site 446462002688 salt bridge; other site 446462002689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462002690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462002691 binding surface 446462002692 TPR repeat; Region: TPR_11; pfam13414 446462002693 TPR motif; other site 446462002694 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462002695 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446462002696 substrate binding pocket [chemical binding]; other site 446462002697 substrate-Mg2+ binding site; other site 446462002698 aspartate-rich region 1; other site 446462002699 aspartate-rich region 2; other site 446462002700 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446462002701 substrate binding pocket [chemical binding]; other site 446462002702 substrate-Mg2+ binding site; other site 446462002703 aspartate-rich region 1; other site 446462002704 aspartate-rich region 2; other site 446462002705 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446462002706 dimer interface [polypeptide binding]; other site 446462002707 ADP-ribose binding site [chemical binding]; other site 446462002708 active site 446462002709 nudix motif; other site 446462002710 metal binding site [ion binding]; metal-binding site 446462002711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462002712 non-specific DNA binding site [nucleotide binding]; other site 446462002713 salt bridge; other site 446462002714 sequence-specific DNA binding site [nucleotide binding]; other site 446462002715 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 446462002716 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462002717 active site 446462002718 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 446462002719 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 446462002720 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 446462002721 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446462002722 intersubunit interface [polypeptide binding]; other site 446462002723 active site 446462002724 Zn2+ binding site [ion binding]; other site 446462002725 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 446462002726 Cupin domain; Region: Cupin_2; cl17218 446462002727 Phosphotransferase enzyme family; Region: APH; pfam01636 446462002728 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462002729 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446462002730 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446462002731 D-pathway; other site 446462002732 Putative ubiquinol binding site [chemical binding]; other site 446462002733 Low-spin heme (heme b) binding site [chemical binding]; other site 446462002734 Putative water exit pathway; other site 446462002735 Binuclear center (heme o3/CuB) [ion binding]; other site 446462002736 K-pathway; other site 446462002737 Putative proton exit pathway; other site 446462002738 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446462002739 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446462002740 phosphoserine phosphatase SerB; Region: serB; TIGR00338 446462002741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462002742 motif II; other site 446462002743 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 446462002744 dimer interface [polypeptide binding]; other site 446462002745 putative active site [active] 446462002746 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 446462002747 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 446462002748 putative active site [active] 446462002749 catalytic site [active] 446462002750 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 446462002751 putative active site [active] 446462002752 catalytic site [active] 446462002753 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 446462002754 DEAD/DEAH box helicase; Region: DEAD; pfam00270 446462002755 ATP binding site [chemical binding]; other site 446462002756 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462002757 putative Mg++ binding site [ion binding]; other site 446462002758 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 446462002759 BioY family; Region: BioY; pfam02632 446462002760 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462002761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462002762 active site 446462002763 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 446462002764 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 446462002765 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446462002766 active site 446462002767 homodimer interface [polypeptide binding]; other site 446462002768 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446462002769 Isochorismatase family; Region: Isochorismatase; pfam00857 446462002770 catalytic triad [active] 446462002771 conserved cis-peptide bond; other site 446462002772 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 446462002773 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 446462002774 active site 446462002775 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 446462002776 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 446462002777 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 446462002778 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 446462002779 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 446462002780 MPN+ (JAMM) motif; other site 446462002781 Zinc-binding site [ion binding]; other site 446462002782 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 446462002783 MoaE interaction surface [polypeptide binding]; other site 446462002784 MoeB interaction surface [polypeptide binding]; other site 446462002785 thiocarboxylated glycine; other site 446462002786 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446462002787 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446462002788 dimer interface [polypeptide binding]; other site 446462002789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462002790 catalytic residue [active] 446462002791 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446462002792 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446462002793 Rhomboid family; Region: Rhomboid; pfam01694 446462002794 glutamate racemase; Provisional; Region: PRK00865 446462002795 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446462002796 ribonuclease PH; Reviewed; Region: rph; PRK00173 446462002797 Ribonuclease PH; Region: RNase_PH_bact; cd11362 446462002798 hexamer interface [polypeptide binding]; other site 446462002799 active site 446462002800 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 446462002801 active site 446462002802 dimerization interface [polypeptide binding]; other site 446462002803 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446462002804 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446462002805 catalytic triad [active] 446462002806 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446462002807 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 446462002808 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 446462002809 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446462002810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462002811 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 446462002812 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446462002813 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446462002814 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 446462002815 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 446462002816 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 446462002817 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446462002818 S-formylglutathione hydrolase; Region: PLN02442 446462002819 Putative esterase; Region: Esterase; pfam00756 446462002820 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462002821 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446462002822 NAD(P) binding site [chemical binding]; other site 446462002823 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 446462002824 catalytic triad [active] 446462002825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446462002826 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 446462002827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462002828 non-specific DNA binding site [nucleotide binding]; other site 446462002829 salt bridge; other site 446462002830 sequence-specific DNA binding site [nucleotide binding]; other site 446462002831 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446462002832 putative active site [active] 446462002833 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446462002834 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446462002835 glycyl-tRNA synthetase; Provisional; Region: PRK14908 446462002836 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 446462002837 dimer interface [polypeptide binding]; other site 446462002838 motif 1; other site 446462002839 active site 446462002840 motif 2; other site 446462002841 motif 3; other site 446462002842 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446462002843 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462002844 active site 446462002845 catalytic residues [active] 446462002846 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446462002847 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446462002848 putative ligand binding site [chemical binding]; other site 446462002849 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446462002850 DNA-binding site [nucleotide binding]; DNA binding site 446462002851 RNA-binding motif; other site 446462002852 SnoaL-like domain; Region: SnoaL_2; pfam12680 446462002853 alpha-galactosidase; Region: PLN02808; cl17638 446462002854 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 446462002855 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 446462002856 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462002857 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446462002858 active site 446462002859 Uncharacterized conserved protein [Function unknown]; Region: COG4279 446462002860 SWIM zinc finger; Region: SWIM; pfam04434 446462002861 SNF2 Helicase protein; Region: DUF3670; pfam12419 446462002862 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 446462002863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462002864 ATP binding site [chemical binding]; other site 446462002865 putative Mg++ binding site [ion binding]; other site 446462002866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462002867 nucleotide binding region [chemical binding]; other site 446462002868 ATP-binding site [chemical binding]; other site 446462002869 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446462002870 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446462002871 cofactor binding site; other site 446462002872 DNA binding site [nucleotide binding] 446462002873 substrate interaction site [chemical binding]; other site 446462002874 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446462002875 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 446462002876 additional DNA contacts [nucleotide binding]; other site 446462002877 mismatch recognition site; other site 446462002878 active site 446462002879 zinc binding site [ion binding]; other site 446462002880 DNA intercalation site [nucleotide binding]; other site 446462002881 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 446462002882 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 446462002883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 446462002884 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 446462002885 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446462002886 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446462002887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462002888 Walker A/P-loop; other site 446462002889 ATP binding site [chemical binding]; other site 446462002890 Q-loop/lid; other site 446462002891 ABC transporter signature motif; other site 446462002892 Walker B; other site 446462002893 D-loop; other site 446462002894 H-loop/switch region; other site 446462002895 ABC transporter; Region: ABC_tran_2; pfam12848 446462002896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462002897 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 446462002898 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 446462002899 catalytic site [active] 446462002900 putative active site [active] 446462002901 putative substrate binding site [chemical binding]; other site 446462002902 dimer interface [polypeptide binding]; other site 446462002903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462002904 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446462002905 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446462002906 conserved cys residue [active] 446462002907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462002908 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462002909 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446462002910 non-specific DNA interactions [nucleotide binding]; other site 446462002911 DNA binding site [nucleotide binding] 446462002912 sequence specific DNA binding site [nucleotide binding]; other site 446462002913 putative cAMP binding site [chemical binding]; other site 446462002914 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446462002915 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446462002916 putative substrate binding site [chemical binding]; other site 446462002917 putative ATP binding site [chemical binding]; other site 446462002918 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446462002919 active site 446462002920 phosphorylation site [posttranslational modification] 446462002921 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 446462002922 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 446462002923 active site 446462002924 P-loop; other site 446462002925 phosphorylation site [posttranslational modification] 446462002926 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 446462002927 Bacterial PH domain; Region: DUF304; pfam03703 446462002928 Bacterial PH domain; Region: DUF304; pfam03703 446462002929 Bacterial PH domain; Region: DUF304; cl01348 446462002930 acyl-CoA synthetase; Validated; Region: PRK07788 446462002931 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462002932 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462002933 acyl-activating enzyme (AAE) consensus motif; other site 446462002934 AMP binding site [chemical binding]; other site 446462002935 active site 446462002936 CoA binding site [chemical binding]; other site 446462002937 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462002938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462002939 putative DNA binding site [nucleotide binding]; other site 446462002940 putative Zn2+ binding site [ion binding]; other site 446462002941 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446462002942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462002943 TPR motif; other site 446462002944 binding surface 446462002945 TPR repeat; Region: TPR_11; pfam13414 446462002946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446462002947 TPR repeat; Region: TPR_11; pfam13414 446462002948 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 446462002949 Protein export membrane protein; Region: SecD_SecF; cl14618 446462002950 Protein export membrane protein; Region: SecD_SecF; cl14618 446462002951 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 446462002952 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 446462002953 putative active site [active] 446462002954 putative substrate binding site [chemical binding]; other site 446462002955 putative FMN binding site [chemical binding]; other site 446462002956 putative catalytic residues [active] 446462002957 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 446462002958 Helix-turn-helix domain; Region: HTH_18; pfam12833 446462002959 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 446462002960 active site 446462002961 catalytic residues [active] 446462002962 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 446462002963 metal binding site [ion binding]; metal-binding site 446462002964 ligand binding site [chemical binding]; other site 446462002965 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 446462002966 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 446462002967 active site 446462002968 DNA binding site [nucleotide binding] 446462002969 catalytic site [active] 446462002970 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462002971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462002972 S-adenosylmethionine binding site [chemical binding]; other site 446462002973 Proline dehydrogenase; Region: Pro_dh; cl03282 446462002974 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462002975 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 446462002976 NAD(P) binding site [chemical binding]; other site 446462002977 catalytic residues [active] 446462002978 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462002979 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 446462002980 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446462002981 Protein of unknown function (DUF402); Region: DUF402; pfam04167 446462002982 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446462002983 DNA binding site [nucleotide binding] 446462002984 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 446462002985 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446462002986 NAD(P) binding site [chemical binding]; other site 446462002987 catalytic residues [active] 446462002988 Protein of unknown function (DUF779); Region: DUF779; pfam05610 446462002989 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 446462002990 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 446462002991 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446462002992 active site 446462002993 Uncharacterized conserved protein [Function unknown]; Region: COG3025 446462002994 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 446462002995 putative active site; other site 446462002996 putative metal binding residues [ion binding]; other site 446462002997 signature motif; other site 446462002998 putative triphosphate binding site [ion binding]; other site 446462002999 CHAD domain; Region: CHAD; pfam05235 446462003000 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446462003001 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 446462003002 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 446462003003 active site 446462003004 substrate binding site [chemical binding]; other site 446462003005 cosubstrate binding site; other site 446462003006 catalytic site [active] 446462003007 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446462003008 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 446462003009 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 446462003010 active site 446462003011 Clp protease; Region: CLP_protease; pfam00574 446462003012 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446462003013 oligomer interface [polypeptide binding]; other site 446462003014 active site residues [active] 446462003015 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446462003016 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446462003017 oligomer interface [polypeptide binding]; other site 446462003018 active site residues [active] 446462003019 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 446462003020 Fic family protein [Function unknown]; Region: COG3177 446462003021 Fic/DOC family; Region: Fic; pfam02661 446462003022 HTH DNA binding domain; Region: HTH_13; pfam11972 446462003023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462003024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462003025 non-specific DNA binding site [nucleotide binding]; other site 446462003026 salt bridge; other site 446462003027 sequence-specific DNA binding site [nucleotide binding]; other site 446462003028 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446462003029 nudix motif; other site 446462003030 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446462003031 Phosphotransferase enzyme family; Region: APH; pfam01636 446462003032 active site 446462003033 ATP binding site [chemical binding]; other site 446462003034 substrate binding site [chemical binding]; other site 446462003035 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462003036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462003037 DNA-binding site [nucleotide binding]; DNA binding site 446462003038 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462003039 Transcription factor WhiB; Region: Whib; pfam02467 446462003040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462003041 active site 446462003042 Int/Topo IB signature motif; other site 446462003043 DNA binding site [nucleotide binding] 446462003044 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462003045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462003046 DNA binding site [nucleotide binding] 446462003047 domain linker motif; other site 446462003048 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462003049 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 446462003050 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446462003051 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446462003052 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446462003053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462003054 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446462003055 Walker A/P-loop; other site 446462003056 ATP binding site [chemical binding]; other site 446462003057 Q-loop/lid; other site 446462003058 ABC transporter signature motif; other site 446462003059 Walker B; other site 446462003060 D-loop; other site 446462003061 H-loop/switch region; other site 446462003062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462003063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462003064 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446462003065 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446462003066 dimer interface [polypeptide binding]; other site 446462003067 ssDNA binding site [nucleotide binding]; other site 446462003068 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446462003069 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 446462003070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462003071 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462003072 ABC transporter; Region: ABC_tran_2; pfam12848 446462003073 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462003074 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 446462003075 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 446462003076 active site 446462003077 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446462003078 Ca binding site [ion binding]; other site 446462003079 catalytic site [active] 446462003080 Aamy_C domain; Region: Aamy_C; smart00632 446462003081 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 446462003082 starch-binding site 2 [chemical binding]; other site 446462003083 starch-binding site 1 [chemical binding]; other site 446462003084 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462003085 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462003086 DNA binding site [nucleotide binding] 446462003087 domain linker motif; other site 446462003088 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462003089 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446462003090 active site 446462003091 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446462003092 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446462003093 active site 446462003094 catalytic site [active] 446462003095 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446462003096 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 446462003097 apolar tunnel; other site 446462003098 heme binding site [chemical binding]; other site 446462003099 dimerization interface [polypeptide binding]; other site 446462003100 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 446462003101 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446462003102 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446462003103 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462003104 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446462003105 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446462003106 active site 446462003107 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 446462003108 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446462003109 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446462003110 Zn binding site [ion binding]; other site 446462003111 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446462003112 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462003113 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 446462003114 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446462003115 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 446462003116 putative DNA binding site [nucleotide binding]; other site 446462003117 catalytic residue [active] 446462003118 putative H2TH interface [polypeptide binding]; other site 446462003119 putative catalytic residues [active] 446462003120 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446462003121 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446462003122 hypothetical protein; Provisional; Region: PRK01346 446462003123 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 446462003124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462003125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462003126 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446462003127 dimerization interface [polypeptide binding]; other site 446462003128 trigger factor; Provisional; Region: tig; PRK01490 446462003129 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446462003130 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 446462003131 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446462003132 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446462003133 oligomer interface [polypeptide binding]; other site 446462003134 active site residues [active] 446462003135 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446462003136 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 446462003137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462003138 Walker A motif; other site 446462003139 ATP binding site [chemical binding]; other site 446462003140 Walker B motif; other site 446462003141 arginine finger; other site 446462003142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 446462003143 Serine hydrolase; Region: Ser_hydrolase; cl17834 446462003144 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462003145 Putative esterase; Region: Esterase; pfam00756 446462003146 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 446462003147 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 446462003148 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446462003149 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 446462003150 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 446462003151 putative molybdopterin cofactor binding site [chemical binding]; other site 446462003152 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 446462003153 putative molybdopterin cofactor binding site; other site 446462003154 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 446462003155 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462003156 active site 446462003157 HIGH motif; other site 446462003158 nucleotide binding site [chemical binding]; other site 446462003159 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 446462003160 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 446462003161 active site 446462003162 KMSKS motif; other site 446462003163 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 446462003164 tRNA binding surface [nucleotide binding]; other site 446462003165 anticodon binding site; other site 446462003166 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 446462003167 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446462003168 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446462003169 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446462003170 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 446462003171 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 446462003172 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446462003173 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 446462003174 active site 446462003175 catalytic site [active] 446462003176 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 446462003177 carbohydrate binding site [chemical binding]; other site 446462003178 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 446462003179 carbohydrate binding site [chemical binding]; other site 446462003180 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 446462003181 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 446462003182 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 446462003183 Ca binding site [ion binding]; other site 446462003184 active site 446462003185 catalytic site [active] 446462003186 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 446462003187 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 446462003188 active site 446462003189 multimer interface [polypeptide binding]; other site 446462003190 nodulation ABC transporter NodI; Provisional; Region: PRK13537 446462003191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462003192 Walker A/P-loop; other site 446462003193 ATP binding site [chemical binding]; other site 446462003194 Q-loop/lid; other site 446462003195 ABC transporter signature motif; other site 446462003196 Walker B; other site 446462003197 D-loop; other site 446462003198 H-loop/switch region; other site 446462003199 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446462003200 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446462003201 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446462003202 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446462003203 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 446462003204 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 446462003205 B12 binding site [chemical binding]; other site 446462003206 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462003207 FeS/SAM binding site; other site 446462003208 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 446462003209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462003210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462003211 DNA binding residues [nucleotide binding] 446462003212 AAA ATPase domain; Region: AAA_16; pfam13191 446462003213 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462003214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462003215 DNA binding residues [nucleotide binding] 446462003216 ApbE family; Region: ApbE; pfam02424 446462003217 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462003218 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462003219 active site 446462003220 catalytic residues [active] 446462003221 catalytic residues [active] 446462003222 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 446462003223 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 446462003224 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446462003225 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 446462003226 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 446462003227 homodimer interface [polypeptide binding]; other site 446462003228 oligonucleotide binding site [chemical binding]; other site 446462003229 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 446462003230 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 446462003231 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 446462003232 GTPase CgtA; Reviewed; Region: obgE; PRK12296 446462003233 GTP1/OBG; Region: GTP1_OBG; pfam01018 446462003234 Obg GTPase; Region: Obg; cd01898 446462003235 G1 box; other site 446462003236 GTP/Mg2+ binding site [chemical binding]; other site 446462003237 Switch I region; other site 446462003238 G2 box; other site 446462003239 G3 box; other site 446462003240 Switch II region; other site 446462003241 G4 box; other site 446462003242 G5 box; other site 446462003243 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 446462003244 gamma-glutamyl kinase; Provisional; Region: PRK05429 446462003245 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 446462003246 substrate binding site [chemical binding]; other site 446462003247 nucleotide binding site [chemical binding]; other site 446462003248 PUA domain; Region: PUA; pfam01472 446462003249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462003250 metabolite-proton symporter; Region: 2A0106; TIGR00883 446462003251 putative substrate translocation pore; other site 446462003252 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446462003253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462003254 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 446462003255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462003256 ATP binding site [chemical binding]; other site 446462003257 putative Mg++ binding site [ion binding]; other site 446462003258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462003259 nucleotide binding region [chemical binding]; other site 446462003260 ATP-binding site [chemical binding]; other site 446462003261 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462003262 active site 446462003263 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 446462003264 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 446462003265 putative catalytic cysteine [active] 446462003266 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462003267 Cytochrome P450; Region: p450; cl12078 446462003268 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 446462003269 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 446462003270 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 446462003271 active site 446462003272 (T/H)XGH motif; other site 446462003273 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 446462003274 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462003275 catalytic core [active] 446462003276 EDD domain protein, DegV family; Region: DegV; TIGR00762 446462003277 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 446462003278 SLBB domain; Region: SLBB; pfam10531 446462003279 comEA protein; Region: comE; TIGR01259 446462003280 Helix-hairpin-helix motif; Region: HHH; pfam00633 446462003281 Competence protein; Region: Competence; pfam03772 446462003282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 446462003283 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446462003284 threonine synthase; Validated; Region: PRK07591 446462003285 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446462003286 homodimer interface [polypeptide binding]; other site 446462003287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462003288 catalytic residue [active] 446462003289 hypothetical protein; Reviewed; Region: PRK07914 446462003290 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 446462003291 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 446462003292 hypothetical protein; Provisional; Region: PRK10621 446462003293 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446462003294 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446462003295 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446462003296 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462003297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 446462003298 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446462003299 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 446462003300 Uncharacterized conserved protein [Function unknown]; Region: COG2308 446462003301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 446462003302 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 446462003303 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446462003304 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 446462003305 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446462003306 GTP-binding protein LepA; Provisional; Region: PRK05433 446462003307 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 446462003308 G1 box; other site 446462003309 putative GEF interaction site [polypeptide binding]; other site 446462003310 GTP/Mg2+ binding site [chemical binding]; other site 446462003311 Switch I region; other site 446462003312 G2 box; other site 446462003313 G3 box; other site 446462003314 Switch II region; other site 446462003315 G4 box; other site 446462003316 G5 box; other site 446462003317 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 446462003318 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 446462003319 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 446462003320 PemK-like protein; Region: PemK; pfam02452 446462003321 HD domain; Region: HD_4; pfam13328 446462003322 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 446462003323 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 446462003324 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446462003325 putative active site [active] 446462003326 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 446462003327 Nitronate monooxygenase; Region: NMO; pfam03060 446462003328 FMN binding site [chemical binding]; other site 446462003329 substrate binding site [chemical binding]; other site 446462003330 putative catalytic residue [active] 446462003331 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446462003332 amino acid transporter; Region: 2A0306; TIGR00909 446462003333 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 446462003334 enoyl-CoA hydratase; Provisional; Region: PRK07827 446462003335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462003336 substrate binding site [chemical binding]; other site 446462003337 oxyanion hole (OAH) forming residues; other site 446462003338 trimer interface [polypeptide binding]; other site 446462003339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 446462003340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462003341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462003342 NAD(P) binding site [chemical binding]; other site 446462003343 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 446462003344 active site 446462003345 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 446462003346 RNAase interaction site [polypeptide binding]; other site 446462003347 YcfA-like protein; Region: YcfA; cl00752 446462003348 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446462003349 putative active site [active] 446462003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462003351 dimer interface [polypeptide binding]; other site 446462003352 conserved gate region; other site 446462003353 putative PBP binding loops; other site 446462003354 ABC-ATPase subunit interface; other site 446462003355 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446462003356 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446462003357 Walker A/P-loop; other site 446462003358 ATP binding site [chemical binding]; other site 446462003359 Q-loop/lid; other site 446462003360 ABC transporter signature motif; other site 446462003361 Walker B; other site 446462003362 D-loop; other site 446462003363 H-loop/switch region; other site 446462003364 NMT1-like family; Region: NMT1_2; pfam13379 446462003365 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 446462003366 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 446462003367 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 446462003368 CysD dimerization site [polypeptide binding]; other site 446462003369 G1 box; other site 446462003370 putative GEF interaction site [polypeptide binding]; other site 446462003371 GTP/Mg2+ binding site [chemical binding]; other site 446462003372 Switch I region; other site 446462003373 G2 box; other site 446462003374 G3 box; other site 446462003375 Switch II region; other site 446462003376 G4 box; other site 446462003377 G5 box; other site 446462003378 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 446462003379 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 446462003380 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 446462003381 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446462003382 Active Sites [active] 446462003383 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 446462003384 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446462003385 Active Sites [active] 446462003386 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 446462003387 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446462003388 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446462003389 coproporphyrinogen III oxidase; Validated; Region: PRK05628 446462003390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462003391 FeS/SAM binding site; other site 446462003392 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 446462003393 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 446462003394 chaperone protein DnaJ; Provisional; Region: PRK14278 446462003395 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446462003396 HSP70 interaction site [polypeptide binding]; other site 446462003397 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446462003398 Zn binding sites [ion binding]; other site 446462003399 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446462003400 dimer interface [polypeptide binding]; other site 446462003401 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 446462003402 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 446462003403 active site 446462003404 catalytic triad [active] 446462003405 oxyanion hole [active] 446462003406 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 446462003407 active site 446462003408 catalytic triad [active] 446462003409 oxyanion hole [active] 446462003410 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446462003411 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462003412 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 446462003413 nucleotide binding site/active site [active] 446462003414 HIT family signature motif; other site 446462003415 catalytic residue [active] 446462003416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446462003417 PhoH-like protein; Region: PhoH; pfam02562 446462003418 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 446462003419 thioester formation/cholesterol transfer; other site 446462003420 PhoH-like protein; Region: PhoH; pfam02562 446462003421 metal-binding heat shock protein; Provisional; Region: PRK00016 446462003422 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446462003423 Domain of unknown function DUF21; Region: DUF21; pfam01595 446462003424 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446462003425 Transporter associated domain; Region: CorC_HlyC; smart01091 446462003426 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462003427 GTPase Era; Reviewed; Region: era; PRK00089 446462003428 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 446462003429 G1 box; other site 446462003430 GTP/Mg2+ binding site [chemical binding]; other site 446462003431 Switch I region; other site 446462003432 G2 box; other site 446462003433 Switch II region; other site 446462003434 G3 box; other site 446462003435 G4 box; other site 446462003436 G5 box; other site 446462003437 KH domain; Region: KH_2; pfam07650 446462003438 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 446462003439 Recombination protein O N terminal; Region: RecO_N; pfam11967 446462003440 Recombination protein O C terminal; Region: RecO_C; pfam02565 446462003441 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 446462003442 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446462003443 catalytic residue [active] 446462003444 putative FPP diphosphate binding site; other site 446462003445 putative FPP binding hydrophobic cleft; other site 446462003446 dimer interface [polypeptide binding]; other site 446462003447 putative IPP diphosphate binding site; other site 446462003448 Predicted permease; Region: DUF318; cl17795 446462003449 TIGR03943 family protein; Region: TIGR03943 446462003450 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446462003451 metal binding site 2 [ion binding]; metal-binding site 446462003452 putative DNA binding helix; other site 446462003453 metal binding site 1 [ion binding]; metal-binding site 446462003454 dimer interface [polypeptide binding]; other site 446462003455 structural Zn2+ binding site [ion binding]; other site 446462003456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462003457 dimerization interface [polypeptide binding]; other site 446462003458 putative DNA binding site [nucleotide binding]; other site 446462003459 putative Zn2+ binding site [ion binding]; other site 446462003460 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 446462003461 glycyl-tRNA synthetase; Provisional; Region: PRK04173 446462003462 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446462003463 motif 1; other site 446462003464 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 446462003465 dimer interface [polypeptide binding]; other site 446462003466 active site 446462003467 motif 2; other site 446462003468 motif 3; other site 446462003469 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 446462003470 anticodon binding site; other site 446462003471 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 446462003472 active site clefts [active] 446462003473 zinc binding site [ion binding]; other site 446462003474 dimer interface [polypeptide binding]; other site 446462003475 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446462003476 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446462003477 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446462003478 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 446462003479 reactive center loop; other site 446462003480 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 446462003481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446462003482 Zn2+ binding site [ion binding]; other site 446462003483 Mg2+ binding site [ion binding]; other site 446462003484 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 446462003485 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446462003486 putative active site [active] 446462003487 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 446462003488 active site pocket [active] 446462003489 oxyanion hole [active] 446462003490 catalytic triad [active] 446462003491 active site nucleophile [active] 446462003492 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446462003493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462003494 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446462003495 DNA primase; Validated; Region: dnaG; PRK05667 446462003496 CHC2 zinc finger; Region: zf-CHC2; pfam01807 446462003497 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 446462003498 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 446462003499 active site 446462003500 metal binding site [ion binding]; metal-binding site 446462003501 interdomain interaction site; other site 446462003502 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 446462003503 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 446462003504 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 446462003505 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446462003506 dimer interface [polypeptide binding]; other site 446462003507 ADP-ribose binding site [chemical binding]; other site 446462003508 active site 446462003509 nudix motif; other site 446462003510 metal binding site [ion binding]; metal-binding site 446462003511 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446462003512 putative active site [active] 446462003513 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462003514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462003515 DNA-binding site [nucleotide binding]; DNA binding site 446462003516 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446462003517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462003518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462003519 non-specific DNA binding site [nucleotide binding]; other site 446462003520 salt bridge; other site 446462003521 sequence-specific DNA binding site [nucleotide binding]; other site 446462003522 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446462003523 nudix motif; other site 446462003524 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 446462003525 active site 446462003526 iron coordination sites [ion binding]; other site 446462003527 substrate binding pocket [chemical binding]; other site 446462003528 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462003529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462003530 DNA-binding site [nucleotide binding]; DNA binding site 446462003531 UTRA domain; Region: UTRA; pfam07702 446462003532 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462003533 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462003534 Helix-turn-helix domain; Region: HTH_17; pfam12728 446462003535 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462003536 active site 446462003537 DNA binding site [nucleotide binding] 446462003538 Int/Topo IB signature motif; other site 446462003539 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 446462003540 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 446462003541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462003542 S-adenosylmethionine binding site [chemical binding]; other site 446462003543 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446462003544 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 446462003545 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 446462003546 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462003547 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 446462003548 DXD motif; other site 446462003549 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462003550 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462003551 Cytochrome P450; Region: p450; cl12078 446462003552 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 446462003553 active site 446462003554 dimer interface [polypeptide binding]; other site 446462003555 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 446462003556 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 446462003557 ligand binding site [chemical binding]; other site 446462003558 homodimer interface [polypeptide binding]; other site 446462003559 NAD(P) binding site [chemical binding]; other site 446462003560 trimer interface B [polypeptide binding]; other site 446462003561 trimer interface A [polypeptide binding]; other site 446462003562 Beta/Gamma crystallin; Region: Crystall; cl02528 446462003563 PAS domain S-box; Region: sensory_box; TIGR00229 446462003564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462003565 putative active site [active] 446462003566 heme pocket [chemical binding]; other site 446462003567 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462003568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462003569 metal binding site [ion binding]; metal-binding site 446462003570 active site 446462003571 I-site; other site 446462003572 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 446462003573 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446462003574 MarR family; Region: MarR_2; pfam12802 446462003575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462003576 CrcB-like protein; Region: CRCB; cl09114 446462003577 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 446462003578 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446462003579 Part of AAA domain; Region: AAA_19; pfam13245 446462003580 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 446462003581 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 446462003582 NAD binding site [chemical binding]; other site 446462003583 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446462003584 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446462003585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462003586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462003587 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 446462003588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462003589 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446462003590 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 446462003591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462003592 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462003593 Walker A/P-loop; other site 446462003594 ATP binding site [chemical binding]; other site 446462003595 Q-loop/lid; other site 446462003596 ABC transporter signature motif; other site 446462003597 Walker B; other site 446462003598 D-loop; other site 446462003599 H-loop/switch region; other site 446462003600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462003601 Walker A/P-loop; other site 446462003602 ATP binding site [chemical binding]; other site 446462003603 ABC transporter; Region: ABC_tran; pfam00005 446462003604 Q-loop/lid; other site 446462003605 ABC transporter signature motif; other site 446462003606 Walker B; other site 446462003607 D-loop; other site 446462003608 H-loop/switch region; other site 446462003609 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446462003610 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462003611 active site 446462003612 ATP binding site [chemical binding]; other site 446462003613 substrate binding site [chemical binding]; other site 446462003614 activation loop (A-loop); other site 446462003615 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446462003616 active site 446462003617 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446462003618 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 446462003619 dimer interface [polypeptide binding]; other site 446462003620 active site 446462003621 acyl carrier protein; Provisional; Region: acpP; PRK00982 446462003622 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446462003623 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446462003624 dimer interface [polypeptide binding]; other site 446462003625 active site 446462003626 CoA binding pocket [chemical binding]; other site 446462003627 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 446462003628 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462003629 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 446462003630 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462003631 Conserved TM helix; Region: TM_helix; pfam05552 446462003632 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 446462003633 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462003634 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462003635 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 446462003636 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 446462003637 dimer interface [polypeptide binding]; other site 446462003638 TPP-binding site [chemical binding]; other site 446462003639 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 446462003640 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446462003641 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 446462003642 dimer interface [polypeptide binding]; other site 446462003643 catalytic triad [active] 446462003644 Uncharacterized conserved protein [Function unknown]; Region: COG3268 446462003645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462003646 NAD(P) binding site [chemical binding]; other site 446462003647 lipoyl synthase; Provisional; Region: PRK05481 446462003648 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462003649 FeS/SAM binding site; other site 446462003650 short chain dehydrogenase; Provisional; Region: PRK06197 446462003651 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446462003652 putative NAD(P) binding site [chemical binding]; other site 446462003653 active site 446462003654 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446462003655 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462003656 lipoate-protein ligase B; Provisional; Region: PRK14345 446462003657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462003658 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462003659 sequence-specific DNA binding site [nucleotide binding]; other site 446462003660 salt bridge; other site 446462003661 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 446462003662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462003663 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462003664 NAD(P) binding site [chemical binding]; other site 446462003665 active site 446462003666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462003667 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 446462003668 NAD(P) binding site [chemical binding]; other site 446462003669 active site 446462003670 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 446462003671 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446462003672 E3 interaction surface; other site 446462003673 lipoyl attachment site [posttranslational modification]; other site 446462003674 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446462003675 E3 interaction surface; other site 446462003676 lipoyl attachment site [posttranslational modification]; other site 446462003677 e3 binding domain; Region: E3_binding; pfam02817 446462003678 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446462003679 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 446462003680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462003681 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446462003682 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 446462003683 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462003684 NAD binding site [chemical binding]; other site 446462003685 substrate binding site [chemical binding]; other site 446462003686 putative active site [active] 446462003687 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446462003688 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446462003689 interface (dimer of trimers) [polypeptide binding]; other site 446462003690 Substrate-binding/catalytic site; other site 446462003691 Zn-binding sites [ion binding]; other site 446462003692 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 446462003693 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 446462003694 homodimer interface [polypeptide binding]; other site 446462003695 substrate-cofactor binding pocket; other site 446462003696 catalytic residue [active] 446462003697 cobalamin synthase; Reviewed; Region: cobS; PRK00235 446462003698 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 446462003699 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 446462003700 putative dimer interface [polypeptide binding]; other site 446462003701 active site pocket [active] 446462003702 putative cataytic base [active] 446462003703 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 446462003704 homotrimer interface [polypeptide binding]; other site 446462003705 Walker A motif; other site 446462003706 GTP binding site [chemical binding]; other site 446462003707 Walker B motif; other site 446462003708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462003709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462003710 active site 446462003711 catalytic tetrad [active] 446462003712 Immunity protein Imm1; Region: Imm1; pfam14430 446462003713 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446462003714 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 446462003715 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 446462003716 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 446462003717 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 446462003718 active site 446462003719 dimer interface [polypeptide binding]; other site 446462003720 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446462003721 Ligand Binding Site [chemical binding]; other site 446462003722 Molecular Tunnel; other site 446462003723 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 446462003724 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 446462003725 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 446462003726 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462003727 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462003728 putative acyl-acceptor binding pocket; other site 446462003729 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446462003730 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446462003731 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446462003732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 446462003733 active site 446462003734 phosphorylation site [posttranslational modification] 446462003735 intermolecular recognition site; other site 446462003736 dimerization interface [polypeptide binding]; other site 446462003737 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 446462003738 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 446462003739 Cytochrome c; Region: Cytochrom_C; pfam00034 446462003740 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 446462003741 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446462003742 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446462003743 iron-sulfur cluster [ion binding]; other site 446462003744 [2Fe-2S] cluster binding site [ion binding]; other site 446462003745 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 446462003746 heme bH binding site [chemical binding]; other site 446462003747 intrachain domain interface; other site 446462003748 heme bL binding site [chemical binding]; other site 446462003749 interchain domain interface [polypeptide binding]; other site 446462003750 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 446462003751 Qo binding site; other site 446462003752 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462003753 AsnC family; Region: AsnC_trans_reg; pfam01037 446462003754 hypothetical protein; Validated; Region: PRK07883 446462003755 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446462003756 active site 446462003757 catalytic site [active] 446462003758 substrate binding site [chemical binding]; other site 446462003759 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446462003760 GIY-YIG motif/motif A; other site 446462003761 active site 446462003762 catalytic site [active] 446462003763 putative DNA binding site [nucleotide binding]; other site 446462003764 metal binding site [ion binding]; metal-binding site 446462003765 YacP-like NYN domain; Region: NYN_YacP; cl01491 446462003766 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446462003767 NlpC/P60 family; Region: NLPC_P60; pfam00877 446462003768 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 446462003769 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462003770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462003771 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446462003772 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462003773 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446462003774 acyl-activating enzyme (AAE) consensus motif; other site 446462003775 putative AMP binding site [chemical binding]; other site 446462003776 putative active site [active] 446462003777 putative CoA binding site [chemical binding]; other site 446462003778 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462003779 active site 446462003780 metal binding site [ion binding]; metal-binding site 446462003781 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 446462003782 putative hydrophobic ligand binding site [chemical binding]; other site 446462003783 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 446462003784 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446462003785 DTAP/Switch II; other site 446462003786 Switch I; other site 446462003787 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446462003788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446462003789 nucleotide binding site [chemical binding]; other site 446462003790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462003791 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 446462003792 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462003793 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462003794 ATP binding site [chemical binding]; other site 446462003795 Mg2+ binding site [ion binding]; other site 446462003796 G-X-G motif; other site 446462003797 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462003798 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462003799 putative acyl-acceptor binding pocket; other site 446462003800 phosphofructokinase; Region: PFK_mixed; TIGR02483 446462003801 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 446462003802 active site 446462003803 ADP/pyrophosphate binding site [chemical binding]; other site 446462003804 dimerization interface [polypeptide binding]; other site 446462003805 allosteric effector site; other site 446462003806 fructose-1,6-bisphosphate binding site; other site 446462003807 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 446462003808 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462003809 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462003810 active site 446462003811 ATP binding site [chemical binding]; other site 446462003812 substrate binding site [chemical binding]; other site 446462003813 activation loop (A-loop); other site 446462003814 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462003815 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462003816 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462003817 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446462003818 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 446462003819 phytoene desaturase; Region: crtI_fam; TIGR02734 446462003820 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446462003821 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446462003822 substrate binding pocket [chemical binding]; other site 446462003823 chain length determination region; other site 446462003824 substrate-Mg2+ binding site; other site 446462003825 catalytic residues [active] 446462003826 aspartate-rich region 1; other site 446462003827 active site lid residues [active] 446462003828 aspartate-rich region 2; other site 446462003829 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 446462003830 FAD binding site [chemical binding]; other site 446462003831 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446462003832 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446462003833 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446462003834 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446462003835 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462003836 Coenzyme A binding pocket [chemical binding]; other site 446462003837 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 446462003838 putative deacylase active site [active] 446462003839 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446462003840 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446462003841 putative active site [active] 446462003842 putative metal binding site [ion binding]; other site 446462003843 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462003844 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446462003845 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446462003846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462003847 DNA-binding site [nucleotide binding]; DNA binding site 446462003848 FCD domain; Region: FCD; pfam07729 446462003849 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 446462003850 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 446462003851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462003852 catalytic residue [active] 446462003853 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 446462003854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462003855 ATP binding site [chemical binding]; other site 446462003856 putative Mg++ binding site [ion binding]; other site 446462003857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462003858 nucleotide binding region [chemical binding]; other site 446462003859 ATP-binding site [chemical binding]; other site 446462003860 DEAD/H associated; Region: DEAD_assoc; pfam08494 446462003861 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 446462003862 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446462003863 nucleotide binding site [chemical binding]; other site 446462003864 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446462003865 SBD interface [polypeptide binding]; other site 446462003866 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 446462003867 recombinase A; Provisional; Region: recA; PRK09354 446462003868 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 446462003869 hexamer interface [polypeptide binding]; other site 446462003870 Walker A motif; other site 446462003871 ATP binding site [chemical binding]; other site 446462003872 Walker B motif; other site 446462003873 recombination regulator RecX; Reviewed; Region: recX; PRK00117 446462003874 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446462003875 active site 446462003876 intersubunit interface [polypeptide binding]; other site 446462003877 catalytic residue [active] 446462003878 phosphogluconate dehydratase; Validated; Region: PRK09054 446462003879 6-phosphogluconate dehydratase; Region: edd; TIGR01196 446462003880 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 446462003881 L-aspartate oxidase; Provisional; Region: PRK06175 446462003882 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446462003883 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 446462003884 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446462003885 catalytic loop [active] 446462003886 iron binding site [ion binding]; other site 446462003887 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446462003888 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 446462003889 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 446462003890 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 446462003891 active site 446462003892 dimer interface [polypeptide binding]; other site 446462003893 effector binding site; other site 446462003894 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 446462003895 TSCPD domain; Region: TSCPD; pfam12637 446462003896 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 446462003897 ATP cone domain; Region: ATP-cone; pfam03477 446462003898 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 446462003899 LexA repressor; Validated; Region: PRK00215 446462003900 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 446462003901 Catalytic site [active] 446462003902 GTPases [General function prediction only]; Region: HflX; COG2262 446462003903 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 446462003904 HflX GTPase family; Region: HflX; cd01878 446462003905 G1 box; other site 446462003906 GTP/Mg2+ binding site [chemical binding]; other site 446462003907 Switch I region; other site 446462003908 G2 box; other site 446462003909 G3 box; other site 446462003910 Switch II region; other site 446462003911 G4 box; other site 446462003912 G5 box; other site 446462003913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462003914 putative DNA binding site [nucleotide binding]; other site 446462003915 putative Zn2+ binding site [ion binding]; other site 446462003916 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462003917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462003918 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 446462003919 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446462003920 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446462003921 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 446462003922 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 446462003923 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 446462003924 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446462003925 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446462003926 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446462003927 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 446462003928 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 446462003929 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446462003930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462003931 FeS/SAM binding site; other site 446462003932 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 446462003933 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 446462003934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462003935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462003936 dimer interface [polypeptide binding]; other site 446462003937 phosphorylation site [posttranslational modification] 446462003938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462003939 ATP binding site [chemical binding]; other site 446462003940 Mg2+ binding site [ion binding]; other site 446462003941 G-X-G motif; other site 446462003942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462003944 active site 446462003945 phosphorylation site [posttranslational modification] 446462003946 intermolecular recognition site; other site 446462003947 dimerization interface [polypeptide binding]; other site 446462003948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462003949 DNA binding site [nucleotide binding] 446462003950 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446462003951 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446462003952 Walker A/P-loop; other site 446462003953 ATP binding site [chemical binding]; other site 446462003954 Q-loop/lid; other site 446462003955 ABC transporter signature motif; other site 446462003956 Walker B; other site 446462003957 D-loop; other site 446462003958 H-loop/switch region; other site 446462003959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462003960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462003961 substrate binding pocket [chemical binding]; other site 446462003962 membrane-bound complex binding site; other site 446462003963 hinge residues; other site 446462003964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462003965 dimer interface [polypeptide binding]; other site 446462003966 conserved gate region; other site 446462003967 putative PBP binding loops; other site 446462003968 ABC-ATPase subunit interface; other site 446462003969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462003970 dimer interface [polypeptide binding]; other site 446462003971 conserved gate region; other site 446462003972 putative PBP binding loops; other site 446462003973 ABC-ATPase subunit interface; other site 446462003974 EcsC protein family; Region: EcsC; pfam12787 446462003975 CGNR zinc finger; Region: zf-CGNR; pfam11706 446462003976 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 446462003977 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462003978 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 446462003979 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 446462003980 Active_site [active] 446462003981 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 446462003982 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 446462003983 NAD(P) binding site [chemical binding]; other site 446462003984 LDH/MDH dimer interface [polypeptide binding]; other site 446462003985 substrate binding site [chemical binding]; other site 446462003986 adenosine deaminase; Provisional; Region: PRK09358 446462003987 active site 446462003988 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 446462003989 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462003990 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 446462003991 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 446462003992 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446462003993 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462003994 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446462003995 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 446462003996 NAD binding site [chemical binding]; other site 446462003997 homodimer interface [polypeptide binding]; other site 446462003998 active site 446462003999 substrate binding site [chemical binding]; other site 446462004000 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446462004001 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 446462004002 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446462004003 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446462004004 non-specific DNA interactions [nucleotide binding]; other site 446462004005 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 446462004006 DNA binding site [nucleotide binding] 446462004007 sequence specific DNA binding site [nucleotide binding]; other site 446462004008 putative cAMP binding site [chemical binding]; other site 446462004009 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446462004010 FeoA domain; Region: FeoA; pfam04023 446462004011 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446462004012 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446462004013 active site residue [active] 446462004014 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446462004015 active site residue [active] 446462004016 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 446462004017 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 446462004018 active site 446462004019 Zn binding site [ion binding]; other site 446462004020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462004021 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446462004022 CoA binding domain; Region: CoA_binding_2; pfam13380 446462004023 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446462004024 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446462004025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462004026 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462004027 substrate binding pocket [chemical binding]; other site 446462004028 membrane-bound complex binding site; other site 446462004029 hinge residues; other site 446462004030 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462004031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462004032 DNA-binding site [nucleotide binding]; DNA binding site 446462004033 UTRA domain; Region: UTRA; pfam07702 446462004034 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 446462004035 hypothetical protein; Reviewed; Region: PRK09588 446462004036 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446462004037 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446462004038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462004039 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446462004040 Walker A/P-loop; other site 446462004041 ATP binding site [chemical binding]; other site 446462004042 Q-loop/lid; other site 446462004043 ABC transporter signature motif; other site 446462004044 Walker B; other site 446462004045 D-loop; other site 446462004046 H-loop/switch region; other site 446462004047 Coenzyme A binding pocket [chemical binding]; other site 446462004048 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462004049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462004050 non-specific DNA binding site [nucleotide binding]; other site 446462004051 salt bridge; other site 446462004052 sequence-specific DNA binding site [nucleotide binding]; other site 446462004053 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462004054 ribosomal protein L2, bacterial/organellar; Region: rplB_bact; TIGR01171 446462004055 NACHT domain; Region: NACHT; pfam05729 446462004056 AAA ATPase domain; Region: AAA_16; pfam13191 446462004057 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 446462004058 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 446462004059 dimer interface [polypeptide binding]; other site 446462004060 NADP binding site [chemical binding]; other site 446462004061 catalytic residues [active] 446462004062 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462004063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462004064 NAD(P) binding site [chemical binding]; other site 446462004065 active site 446462004066 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446462004067 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462004068 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462004069 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446462004070 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 446462004071 catalytic residue [active] 446462004072 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 446462004073 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 446462004074 active site 446462004075 tetramer interface [polypeptide binding]; other site 446462004076 fumarate hydratase; Provisional; Region: PRK15389 446462004077 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 446462004078 Fumarase C-terminus; Region: Fumerase_C; pfam05683 446462004079 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446462004080 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446462004081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462004082 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462004083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462004084 DNA binding residues [nucleotide binding] 446462004085 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 446462004086 dimerization interface [polypeptide binding]; other site 446462004087 putative tRNAtyr binding site [nucleotide binding]; other site 446462004088 putative active site [active] 446462004089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462004090 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 446462004091 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446462004092 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 446462004093 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 446462004094 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462004095 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446462004096 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 446462004097 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 446462004098 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 446462004099 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446462004100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462004101 ATP binding site [chemical binding]; other site 446462004102 putative Mg++ binding site [ion binding]; other site 446462004103 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446462004104 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446462004105 putative ligand binding site [chemical binding]; other site 446462004106 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446462004107 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446462004108 Walker A/P-loop; other site 446462004109 ATP binding site [chemical binding]; other site 446462004110 Q-loop/lid; other site 446462004111 ABC transporter signature motif; other site 446462004112 Walker B; other site 446462004113 D-loop; other site 446462004114 H-loop/switch region; other site 446462004115 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462004116 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462004117 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462004118 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462004119 TM-ABC transporter signature motif; other site 446462004120 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446462004121 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462004122 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462004123 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446462004124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462004125 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462004126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462004127 DNA binding residues [nucleotide binding] 446462004128 fructokinase; Reviewed; Region: PRK09557 446462004129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462004130 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446462004131 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 446462004132 active site 446462004133 dimerization interface [polypeptide binding]; other site 446462004134 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446462004135 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 446462004136 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 446462004137 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446462004138 trimer interface [polypeptide binding]; other site 446462004139 active site 446462004140 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 446462004141 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446462004142 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446462004143 generic binding surface II; other site 446462004144 ssDNA binding site; other site 446462004145 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446462004146 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446462004147 TrkA-N domain; Region: TrkA_N; pfam02254 446462004148 TrkA-C domain; Region: TrkA_C; pfam02080 446462004149 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446462004150 TrkA-N domain; Region: TrkA_N; pfam02254 446462004151 TrkA-C domain; Region: TrkA_C; pfam02080 446462004152 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446462004153 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446462004154 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446462004155 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446462004156 TPP-binding site; other site 446462004157 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446462004158 PYR/PP interface [polypeptide binding]; other site 446462004159 dimer interface [polypeptide binding]; other site 446462004160 TPP binding site [chemical binding]; other site 446462004161 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446462004162 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 446462004163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462004164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462004165 active site 446462004166 phosphorylation site [posttranslational modification] 446462004167 intermolecular recognition site; other site 446462004168 dimerization interface [polypeptide binding]; other site 446462004169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462004170 DNA binding site [nucleotide binding] 446462004171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462004172 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462004173 dimerization interface [polypeptide binding]; other site 446462004174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462004175 dimer interface [polypeptide binding]; other site 446462004176 phosphorylation site [posttranslational modification] 446462004177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462004178 ATP binding site [chemical binding]; other site 446462004179 Mg2+ binding site [ion binding]; other site 446462004180 G-X-G motif; other site 446462004181 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 446462004182 homodimer interface [polypeptide binding]; other site 446462004183 chemical substrate binding site [chemical binding]; other site 446462004184 oligomer interface [polypeptide binding]; other site 446462004185 metal binding site [ion binding]; metal-binding site 446462004186 EspG family; Region: ESX-1_EspG; pfam14011 446462004187 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 446462004188 Protein of unknown function DUF72; Region: DUF72; pfam01904 446462004189 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 446462004190 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446462004191 oligomeric interface; other site 446462004192 putative active site [active] 446462004193 homodimer interface [polypeptide binding]; other site 446462004194 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462004195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462004196 NAD(P) binding site [chemical binding]; other site 446462004197 active site 446462004198 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 446462004199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462004200 substrate binding site [chemical binding]; other site 446462004201 oxyanion hole (OAH) forming residues; other site 446462004202 trimer interface [polypeptide binding]; other site 446462004203 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462004204 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462004205 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446462004206 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 446462004207 dimer interface [polypeptide binding]; other site 446462004208 active site 446462004209 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 446462004210 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 446462004211 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462004212 DNA binding residues [nucleotide binding] 446462004213 putative dimer interface [polypeptide binding]; other site 446462004214 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 446462004215 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 446462004216 catalytic site [active] 446462004217 putative active site [active] 446462004218 putative substrate binding site [chemical binding]; other site 446462004219 HRDC domain; Region: HRDC; pfam00570 446462004220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462004221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462004222 active site 446462004223 phosphorylation site [posttranslational modification] 446462004224 intermolecular recognition site; other site 446462004225 dimerization interface [polypeptide binding]; other site 446462004226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462004227 DNA binding residues [nucleotide binding] 446462004228 dimerization interface [polypeptide binding]; other site 446462004229 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 446462004230 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 446462004231 active site 446462004232 dimer interface [polypeptide binding]; other site 446462004233 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 446462004234 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 446462004235 substrate binding site [chemical binding]; other site 446462004236 active site 446462004237 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 446462004238 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462004239 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 446462004240 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462004241 active site 446462004242 catalytic residues [active] 446462004243 hypothetical protein; Provisional; Region: PRK05409 446462004244 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446462004245 TIGR04222 domain; Region: near_uncomplex 446462004246 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 446462004247 SelR domain; Region: SelR; pfam01641 446462004248 L-asparaginase II; Region: Asparaginase_II; pfam06089 446462004249 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446462004250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462004251 DNA-binding site [nucleotide binding]; DNA binding site 446462004252 FCD domain; Region: FCD; pfam07729 446462004253 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462004254 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462004255 active site 446462004256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462004257 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462004258 active site 446462004259 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 446462004260 nucleotide binding site [chemical binding]; other site 446462004261 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462004262 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446462004263 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446462004264 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 446462004265 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 446462004266 active site 446462004267 DNA binding site [nucleotide binding] 446462004268 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 446462004269 DNA binding site [nucleotide binding] 446462004270 hypothetical protein; Provisional; Region: PRK14059 446462004271 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 446462004272 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 446462004273 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446462004274 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446462004275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462004276 Walker A/P-loop; other site 446462004277 ATP binding site [chemical binding]; other site 446462004278 Q-loop/lid; other site 446462004279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462004280 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462004281 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462004282 active site 446462004283 oxyanion hole [active] 446462004284 catalytic triad [active] 446462004285 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 446462004286 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 446462004287 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462004288 inhibitor-cofactor binding pocket; inhibition site 446462004289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462004290 catalytic residue [active] 446462004291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 446462004292 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 446462004293 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462004294 catalytic core [active] 446462004295 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 446462004296 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446462004297 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 446462004298 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 446462004299 active site 446462004300 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 446462004301 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 446462004302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 446462004303 SpoOM protein; Region: Spo0M; pfam07070 446462004304 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 446462004305 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462004306 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462004307 active site 446462004308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446462004309 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446462004310 metal ion-dependent adhesion site (MIDAS); other site 446462004311 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 446462004312 active site 446462004313 catalytic site [active] 446462004314 substrate binding site [chemical binding]; other site 446462004315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462004316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462004317 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 446462004318 putative active site [active] 446462004319 putative catalytic site [active] 446462004320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462004321 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446462004322 NAD(P) binding site [chemical binding]; other site 446462004323 active site 446462004324 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 446462004325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462004326 NAD(P) binding site [chemical binding]; other site 446462004327 active site 446462004328 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462004329 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462004330 NAD(P) binding site [chemical binding]; other site 446462004331 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 446462004332 active site 446462004333 catalytic triad [active] 446462004334 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 446462004335 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446462004336 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 446462004337 TrkA-C domain; Region: TrkA_C; pfam02080 446462004338 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 446462004339 cytidylate kinase; Provisional; Region: cmk; PRK00023 446462004340 CMP-binding site; other site 446462004341 The sites determining sugar specificity; other site 446462004342 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462004343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462004344 putative acyl-acceptor binding pocket; other site 446462004345 GTP-binding protein Der; Reviewed; Region: PRK03003 446462004346 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 446462004347 G1 box; other site 446462004348 GTP/Mg2+ binding site [chemical binding]; other site 446462004349 Switch I region; other site 446462004350 G2 box; other site 446462004351 Switch II region; other site 446462004352 G3 box; other site 446462004353 G4 box; other site 446462004354 G5 box; other site 446462004355 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 446462004356 G1 box; other site 446462004357 GTP/Mg2+ binding site [chemical binding]; other site 446462004358 Switch I region; other site 446462004359 G2 box; other site 446462004360 G3 box; other site 446462004361 Switch II region; other site 446462004362 G4 box; other site 446462004363 G5 box; other site 446462004364 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462004365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462004366 active site 446462004367 phosphorylation site [posttranslational modification] 446462004368 intermolecular recognition site; other site 446462004369 dimerization interface [polypeptide binding]; other site 446462004370 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462004371 DNA binding residues [nucleotide binding] 446462004372 dimerization interface [polypeptide binding]; other site 446462004373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462004374 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462004375 active site 446462004376 Int/Topo IB signature motif; other site 446462004377 DNA binding site [nucleotide binding] 446462004378 Helix-turn-helix domain; Region: HTH_31; pfam13560 446462004379 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462004380 Phage tail protein; Region: Sipho_tail; cl17486 446462004381 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 446462004382 active site 446462004383 oxyanion hole [active] 446462004384 catalytic triad [active] 446462004385 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 446462004386 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 446462004387 Phage terminase large subunit; Region: Terminase_3; cl12054 446462004388 Terminase-like family; Region: Terminase_6; pfam03237 446462004389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462004390 non-specific DNA binding site [nucleotide binding]; other site 446462004391 salt bridge; other site 446462004392 sequence-specific DNA binding site [nucleotide binding]; other site 446462004393 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446462004394 nudix motif; other site 446462004395 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 446462004396 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 446462004397 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 446462004398 active site 446462004399 RNA/DNA hybrid binding site [nucleotide binding]; other site 446462004400 von Willebrand factor type A domain; Region: VWA_2; pfam13519 446462004401 alpha-galactosidase; Region: PLN02808; cl17638 446462004402 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462004403 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462004404 putative sugar binding sites [chemical binding]; other site 446462004405 Q-X-W motif; other site 446462004406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462004407 sequence-specific DNA binding site [nucleotide binding]; other site 446462004408 salt bridge; other site 446462004409 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 446462004410 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 446462004411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462004412 Walker A/P-loop; other site 446462004413 ATP binding site [chemical binding]; other site 446462004414 Q-loop/lid; other site 446462004415 ABC transporter signature motif; other site 446462004416 Walker B; other site 446462004417 D-loop; other site 446462004418 H-loop/switch region; other site 446462004419 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 446462004420 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446462004421 Walker A/P-loop; other site 446462004422 ATP binding site [chemical binding]; other site 446462004423 Q-loop/lid; other site 446462004424 ABC transporter signature motif; other site 446462004425 Walker B; other site 446462004426 D-loop; other site 446462004427 H-loop/switch region; other site 446462004428 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446462004429 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446462004430 TM-ABC transporter signature motif; other site 446462004431 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446462004432 TM-ABC transporter signature motif; other site 446462004433 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 446462004434 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 446462004435 putative ligand binding site [chemical binding]; other site 446462004436 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446462004437 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462004438 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462004439 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462004440 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446462004441 substrate binding site [chemical binding]; other site 446462004442 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446462004443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462004444 Walker A/P-loop; other site 446462004445 ATP binding site [chemical binding]; other site 446462004446 Q-loop/lid; other site 446462004447 ABC transporter signature motif; other site 446462004448 Walker B; other site 446462004449 D-loop; other site 446462004450 H-loop/switch region; other site 446462004451 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446462004452 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462004453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462004454 dimer interface [polypeptide binding]; other site 446462004455 conserved gate region; other site 446462004456 putative PBP binding loops; other site 446462004457 ABC-ATPase subunit interface; other site 446462004458 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462004459 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446462004460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462004461 dimer interface [polypeptide binding]; other site 446462004462 conserved gate region; other site 446462004463 putative PBP binding loops; other site 446462004464 ABC-ATPase subunit interface; other site 446462004465 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446462004466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462004467 Walker A/P-loop; other site 446462004468 ATP binding site [chemical binding]; other site 446462004469 Q-loop/lid; other site 446462004470 ABC transporter signature motif; other site 446462004471 Walker B; other site 446462004472 D-loop; other site 446462004473 H-loop/switch region; other site 446462004474 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446462004475 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446462004476 beta-galactosidase; Region: BGL; TIGR03356 446462004477 Protein phosphatase 2C; Region: PP2C; pfam00481 446462004478 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446462004479 active site 446462004480 TspO/MBR family; Region: TspO_MBR; pfam03073 446462004481 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446462004482 DinB superfamily; Region: DinB_2; pfam12867 446462004483 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 446462004484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462004485 Walker A motif; other site 446462004486 ATP binding site [chemical binding]; other site 446462004487 Walker B motif; other site 446462004488 arginine finger; other site 446462004489 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 446462004490 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 446462004491 RuvA N terminal domain; Region: RuvA_N; pfam01330 446462004492 Y-family of DNA polymerases; Region: PolY; cl12025 446462004493 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 446462004494 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 446462004495 active site 446462004496 putative DNA-binding cleft [nucleotide binding]; other site 446462004497 dimer interface [polypeptide binding]; other site 446462004498 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462004499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462004500 metal binding site [ion binding]; metal-binding site 446462004501 active site 446462004502 I-site; other site 446462004503 Preprotein translocase subunit; Region: YajC; pfam02699 446462004504 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 446462004505 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 446462004506 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 446462004507 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 446462004508 Protein export membrane protein; Region: SecD_SecF; cl14618 446462004509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462004510 active site 446462004511 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 446462004512 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446462004513 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446462004514 Zn2+ binding site [ion binding]; other site 446462004515 Mg2+ binding site [ion binding]; other site 446462004516 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446462004517 synthetase active site [active] 446462004518 NTP binding site [chemical binding]; other site 446462004519 metal binding site [ion binding]; metal-binding site 446462004520 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 446462004521 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 446462004522 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446462004523 active site 446462004524 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446462004525 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 446462004526 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 446462004527 dimer interface [polypeptide binding]; other site 446462004528 motif 1; other site 446462004529 active site 446462004530 motif 2; other site 446462004531 motif 3; other site 446462004532 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 446462004533 anticodon binding site; other site 446462004534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462004535 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 446462004536 YibE/F-like protein; Region: YibE_F; pfam07907 446462004537 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 446462004538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462004539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462004540 TIGR03084 family protein; Region: TIGR03084 446462004541 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462004542 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 446462004543 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446462004544 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446462004545 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462004546 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462004547 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 446462004548 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446462004549 carboxyltransferase (CT) interaction site; other site 446462004550 biotinylation site [posttranslational modification]; other site 446462004551 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462004552 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446462004553 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446462004554 active site 446462004555 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 446462004556 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462004557 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462004558 calcium binding site 2 [ion binding]; other site 446462004559 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446462004560 active site 446462004561 catalytic triad [active] 446462004562 calcium binding site 1 [ion binding]; other site 446462004563 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462004564 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462004565 calcium binding site 2 [ion binding]; other site 446462004566 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446462004567 active site 446462004568 catalytic triad [active] 446462004569 calcium binding site 1 [ion binding]; other site 446462004570 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 446462004571 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 446462004572 dimer interface [polypeptide binding]; other site 446462004573 anticodon binding site; other site 446462004574 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 446462004575 homodimer interface [polypeptide binding]; other site 446462004576 motif 1; other site 446462004577 active site 446462004578 motif 2; other site 446462004579 GAD domain; Region: GAD; pfam02938 446462004580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446462004581 active site 446462004582 motif 3; other site 446462004583 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 446462004584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462004585 active site 446462004586 GtrA-like protein; Region: GtrA; pfam04138 446462004587 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 446462004588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462004589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462004590 dimer interface [polypeptide binding]; other site 446462004591 phosphorylation site [posttranslational modification] 446462004592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462004593 Mg2+ binding site [ion binding]; other site 446462004594 G-X-G motif; other site 446462004595 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462004596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462004597 active site 446462004598 phosphorylation site [posttranslational modification] 446462004599 intermolecular recognition site; other site 446462004600 dimerization interface [polypeptide binding]; other site 446462004601 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462004602 DNA binding site [nucleotide binding] 446462004603 CopC domain; Region: CopC; pfam04234 446462004604 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 446462004605 active site 446462004606 SUMO-1 interface [polypeptide binding]; other site 446462004607 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446462004608 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446462004609 RNA binding surface [nucleotide binding]; other site 446462004610 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446462004611 Bacterial sugar transferase; Region: Bac_transf; pfam02397 446462004612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462004613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462004614 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 446462004615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462004616 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462004617 NAD(P) binding site [chemical binding]; other site 446462004618 active site 446462004619 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 446462004620 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446462004621 inhibitor-cofactor binding pocket; inhibition site 446462004622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462004623 catalytic residue [active] 446462004624 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 446462004625 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 446462004626 Bacterial Ig-like domain; Region: Big_5; pfam13205 446462004627 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 446462004628 Bacterial Ig-like domain; Region: Big_5; pfam13205 446462004629 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 446462004630 Bacterial Ig-like domain; Region: Big_5; pfam13205 446462004631 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 446462004632 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446462004633 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 446462004634 putative trimer interface [polypeptide binding]; other site 446462004635 putative CoA binding site [chemical binding]; other site 446462004636 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 446462004637 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446462004638 inhibitor-cofactor binding pocket; inhibition site 446462004639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462004640 catalytic residue [active] 446462004641 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 446462004642 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 446462004643 putative trimer interface [polypeptide binding]; other site 446462004644 putative active site [active] 446462004645 putative substrate binding site [chemical binding]; other site 446462004646 putative CoA binding site [chemical binding]; other site 446462004647 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 446462004648 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 446462004649 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 446462004650 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462004651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462004652 active site 446462004653 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 446462004654 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 446462004655 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462004656 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 446462004657 active site 446462004658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462004659 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 446462004660 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 446462004661 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 446462004662 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 446462004663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462004664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462004665 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 446462004666 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446462004667 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462004668 active site 446462004669 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 446462004670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462004671 putative homodimer interface [polypeptide binding]; other site 446462004672 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462004673 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462004674 active site 446462004675 ATP binding site [chemical binding]; other site 446462004676 substrate binding site [chemical binding]; other site 446462004677 activation loop (A-loop); other site 446462004678 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446462004679 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462004680 dimerization interface [polypeptide binding]; other site 446462004681 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462004682 dimer interface [polypeptide binding]; other site 446462004683 putative CheW interface [polypeptide binding]; other site 446462004684 enoyl-CoA hydratase; Provisional; Region: PRK09076 446462004685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462004686 substrate binding site [chemical binding]; other site 446462004687 oxyanion hole (OAH) forming residues; other site 446462004688 trimer interface [polypeptide binding]; other site 446462004689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462004690 Coenzyme A binding pocket [chemical binding]; other site 446462004691 YCII-related domain; Region: YCII; pfam03795 446462004692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462004693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462004694 DNA binding residues [nucleotide binding] 446462004695 dimerization interface [polypeptide binding]; other site 446462004696 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446462004697 CoenzymeA binding site [chemical binding]; other site 446462004698 subunit interaction site [polypeptide binding]; other site 446462004699 PHB binding site; other site 446462004700 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 446462004701 hydrophobic ligand binding site; other site 446462004702 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 446462004703 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 446462004704 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 446462004705 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 446462004706 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446462004707 RNA binding site [nucleotide binding]; other site 446462004708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462004709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462004710 active site 446462004711 catalytic tetrad [active] 446462004712 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462004713 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446462004714 enoyl-CoA hydratase; Provisional; Region: PRK06127 446462004715 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462004716 substrate binding site [chemical binding]; other site 446462004717 oxyanion hole (OAH) forming residues; other site 446462004718 trimer interface [polypeptide binding]; other site 446462004719 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462004720 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 446462004721 Zn binding site [ion binding]; other site 446462004722 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 446462004723 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446462004724 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 446462004725 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462004726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462004727 catalytic residue [active] 446462004728 YheO-like PAS domain; Region: PAS_6; pfam08348 446462004729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 446462004730 HTH domain; Region: HTH_22; pfam13309 446462004731 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446462004732 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446462004733 Walker A/P-loop; other site 446462004734 ATP binding site [chemical binding]; other site 446462004735 Q-loop/lid; other site 446462004736 ABC transporter signature motif; other site 446462004737 Walker B; other site 446462004738 D-loop; other site 446462004739 H-loop/switch region; other site 446462004740 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446462004741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462004742 dimer interface [polypeptide binding]; other site 446462004743 conserved gate region; other site 446462004744 putative PBP binding loops; other site 446462004745 ABC-ATPase subunit interface; other site 446462004746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462004747 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462004748 substrate binding pocket [chemical binding]; other site 446462004749 membrane-bound complex binding site; other site 446462004750 hinge residues; other site 446462004751 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446462004752 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446462004753 catalytic residues [active] 446462004754 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446462004755 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 446462004756 active site 446462004757 putative homodimer interface [polypeptide binding]; other site 446462004758 SAM binding site [chemical binding]; other site 446462004759 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 446462004760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462004761 S-adenosylmethionine binding site [chemical binding]; other site 446462004762 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 446462004763 active site 446462004764 SAM binding site [chemical binding]; other site 446462004765 homodimer interface [polypeptide binding]; other site 446462004766 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 446462004767 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 446462004768 active site 446462004769 SAM binding site [chemical binding]; other site 446462004770 homodimer interface [polypeptide binding]; other site 446462004771 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 446462004772 homodimer interface [polypeptide binding]; other site 446462004773 active site 446462004774 SAM binding site [chemical binding]; other site 446462004775 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 446462004776 Precorrin-8X methylmutase; Region: CbiC; pfam02570 446462004777 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446462004778 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 446462004779 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 446462004780 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 446462004781 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462004782 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462004783 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446462004784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462004785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462004786 dimer interface [polypeptide binding]; other site 446462004787 ABC-ATPase subunit interface; other site 446462004788 putative PBP binding loops; other site 446462004789 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462004790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462004791 dimer interface [polypeptide binding]; other site 446462004792 conserved gate region; other site 446462004793 putative PBP binding loops; other site 446462004794 ABC-ATPase subunit interface; other site 446462004795 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446462004796 beta-galactosidase; Region: BGL; TIGR03356 446462004797 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462004798 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462004799 DNA binding site [nucleotide binding] 446462004800 domain linker motif; other site 446462004801 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 446462004802 putative dimerization interface [polypeptide binding]; other site 446462004803 putative ligand binding site [chemical binding]; other site 446462004804 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 446462004805 Cellulose binding domain; Region: CBM_2; pfam00553 446462004806 Helix-turn-helix domain; Region: HTH_31; pfam13560 446462004807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462004808 Walker A/P-loop; other site 446462004809 ATP binding site [chemical binding]; other site 446462004810 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446462004811 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446462004812 structural tetrad; other site 446462004813 MarR family; Region: MarR_2; cl17246 446462004814 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462004815 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462004816 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462004817 xylose isomerase; Provisional; Region: PRK12677 446462004818 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 446462004819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462004820 nucleotide binding site [chemical binding]; other site 446462004821 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462004822 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462004823 active site 446462004824 metal binding site [ion binding]; metal-binding site 446462004825 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 446462004826 putative hydrophobic ligand binding site [chemical binding]; other site 446462004827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462004828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 446462004829 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 446462004830 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446462004831 NAD binding site [chemical binding]; other site 446462004832 catalytic Zn binding site [ion binding]; other site 446462004833 structural Zn binding site [ion binding]; other site 446462004834 ChaB; Region: ChaB; pfam06150 446462004835 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 446462004836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462004837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462004838 DNA binding site [nucleotide binding] 446462004839 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 446462004840 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462004841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462004842 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 446462004843 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 446462004844 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 446462004845 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 446462004846 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 446462004847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462004848 motif II; other site 446462004849 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446462004850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462004851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462004852 dimerization interface [polypeptide binding]; other site 446462004853 putative DNA binding site [nucleotide binding]; other site 446462004854 putative Zn2+ binding site [ion binding]; other site 446462004855 Transcription factor WhiB; Region: Whib; pfam02467 446462004856 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462004857 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 446462004858 DNA binding residues [nucleotide binding] 446462004859 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 446462004860 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462004861 anti sigma factor interaction site; other site 446462004862 regulatory phosphorylation site [posttranslational modification]; other site 446462004863 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462004864 anti sigma factor interaction site; other site 446462004865 regulatory phosphorylation site [posttranslational modification]; other site 446462004866 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446462004867 NlpC/P60 family; Region: NLPC_P60; pfam00877 446462004868 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446462004869 Cellulose binding domain; Region: CBM_2; pfam00553 446462004870 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462004871 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462004872 DNA binding site [nucleotide binding] 446462004873 domain linker motif; other site 446462004874 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 446462004875 putative dimerization interface [polypeptide binding]; other site 446462004876 putative ligand binding site [chemical binding]; other site 446462004877 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462004878 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462004879 DNA binding site [nucleotide binding] 446462004880 domain linker motif; other site 446462004881 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462004882 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446462004883 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462004884 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446462004885 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446462004886 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 446462004887 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462004888 Cellulose binding domain; Region: CBM_2; pfam00553 446462004889 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 446462004890 active site 446462004891 catalytic triad [active] 446462004892 oxyanion hole [active] 446462004893 Cellulose binding domain; Region: CBM_2; pfam00553 446462004894 YCII-related domain; Region: YCII; cl00999 446462004895 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462004896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462004897 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446462004898 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462004899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462004900 non-specific DNA binding site [nucleotide binding]; other site 446462004901 salt bridge; other site 446462004902 sequence-specific DNA binding site [nucleotide binding]; other site 446462004903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462004904 salt bridge; other site 446462004905 non-specific DNA binding site [nucleotide binding]; other site 446462004906 sequence-specific DNA binding site [nucleotide binding]; other site 446462004907 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 446462004908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462004909 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 446462004910 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 446462004911 active site 446462004912 dimer interface [polypeptide binding]; other site 446462004913 Predicted membrane protein [Function unknown]; Region: COG1470 446462004914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462004915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462004916 DNA binding site [nucleotide binding] 446462004917 domain linker motif; other site 446462004918 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462004919 dimerization interface [polypeptide binding]; other site 446462004920 ligand binding site [chemical binding]; other site 446462004921 Amb_all domain; Region: Amb_all; smart00656 446462004922 putative pectinesterase; Region: PLN02432; cl01911 446462004923 Pectinesterase; Region: Pectinesterase; pfam01095 446462004924 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446462004925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462004926 dimer interface [polypeptide binding]; other site 446462004927 conserved gate region; other site 446462004928 putative PBP binding loops; other site 446462004929 ABC-ATPase subunit interface; other site 446462004930 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462004931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462004932 dimer interface [polypeptide binding]; other site 446462004933 conserved gate region; other site 446462004934 putative PBP binding loops; other site 446462004935 ABC-ATPase subunit interface; other site 446462004936 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462004937 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462004938 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446462004939 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446462004940 metal binding site [ion binding]; metal-binding site 446462004941 substrate binding pocket [chemical binding]; other site 446462004942 Amb_all domain; Region: Amb_all; smart00656 446462004943 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446462004944 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 446462004945 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446462004946 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462004947 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462004948 putative sugar binding sites [chemical binding]; other site 446462004949 Q-X-W motif; other site 446462004950 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446462004951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462004952 active site 446462004953 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462004954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462004955 TM-ABC transporter signature motif; other site 446462004956 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462004957 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462004958 TM-ABC transporter signature motif; other site 446462004959 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446462004960 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446462004961 Walker A/P-loop; other site 446462004962 ATP binding site [chemical binding]; other site 446462004963 Q-loop/lid; other site 446462004964 ABC transporter signature motif; other site 446462004965 Walker B; other site 446462004966 D-loop; other site 446462004967 H-loop/switch region; other site 446462004968 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446462004969 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 446462004970 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446462004971 putative ligand binding site [chemical binding]; other site 446462004972 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462004973 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446462004974 active site 446462004975 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 446462004976 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446462004977 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446462004978 active site 446462004979 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 446462004980 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462004981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446462004982 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462004983 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462004984 DNA binding site [nucleotide binding] 446462004985 domain linker motif; other site 446462004986 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446462004987 ligand binding site [chemical binding]; other site 446462004988 dimerization interface (open form) [polypeptide binding]; other site 446462004989 dimerization interface (closed form) [polypeptide binding]; other site 446462004990 ribulokinase; Provisional; Region: PRK04123 446462004991 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 446462004992 N- and C-terminal domain interface [polypeptide binding]; other site 446462004993 active site 446462004994 MgATP binding site [chemical binding]; other site 446462004995 catalytic site [active] 446462004996 metal binding site [ion binding]; metal-binding site 446462004997 carbohydrate binding site [chemical binding]; other site 446462004998 homodimer interface [polypeptide binding]; other site 446462004999 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 446462005000 intersubunit interface [polypeptide binding]; other site 446462005001 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 446462005002 active site 446462005003 Zn2+ binding site [ion binding]; other site 446462005004 L-arabinose isomerase; Provisional; Region: PRK02929 446462005005 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 446462005006 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 446462005007 trimer interface [polypeptide binding]; other site 446462005008 putative substrate binding site [chemical binding]; other site 446462005009 putative metal binding site [ion binding]; other site 446462005010 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446462005011 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446462005012 putative ligand binding site [chemical binding]; other site 446462005013 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 446462005014 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446462005015 Walker A/P-loop; other site 446462005016 ATP binding site [chemical binding]; other site 446462005017 Q-loop/lid; other site 446462005018 ABC transporter signature motif; other site 446462005019 Walker B; other site 446462005020 D-loop; other site 446462005021 H-loop/switch region; other site 446462005022 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446462005023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462005024 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462005025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462005026 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462005027 TM-ABC transporter signature motif; other site 446462005028 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 446462005029 putative active site [active] 446462005030 Cellulose binding domain; Region: CBM_2; pfam00553 446462005031 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 446462005032 metal binding site [ion binding]; metal-binding site 446462005033 active site 446462005034 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446462005035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462005036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462005037 DNA binding site [nucleotide binding] 446462005038 domain linker motif; other site 446462005039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462005040 ligand binding site [chemical binding]; other site 446462005041 dimerization interface [polypeptide binding]; other site 446462005042 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446462005043 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446462005044 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446462005045 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 446462005046 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 446462005047 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446462005048 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446462005049 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 446462005050 Endonuclease I; Region: Endonuclease_1; pfam04231 446462005051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005052 ATP binding site [chemical binding]; other site 446462005053 G-X-G motif; other site 446462005054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462005055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005056 active site 446462005057 phosphorylation site [posttranslational modification] 446462005058 intermolecular recognition site; other site 446462005059 dimerization interface [polypeptide binding]; other site 446462005060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462005061 DNA binding residues [nucleotide binding] 446462005062 dimerization interface [polypeptide binding]; other site 446462005063 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 446462005064 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 446462005065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462005066 active site 446462005067 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 446462005068 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 446462005069 metal ion-dependent adhesion site (MIDAS); other site 446462005070 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462005071 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 446462005072 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462005073 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462005074 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462005075 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462005076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462005077 OsmC-like protein; Region: OsmC; pfam02566 446462005078 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 446462005079 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462005080 active site 446462005081 oxyanion hole [active] 446462005082 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446462005083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462005084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462005085 non-specific DNA binding site [nucleotide binding]; other site 446462005086 salt bridge; other site 446462005087 sequence-specific DNA binding site [nucleotide binding]; other site 446462005088 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446462005089 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 446462005090 putative active site [active] 446462005091 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446462005092 Immunity protein Imm1; Region: Imm1; pfam14430 446462005093 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446462005094 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446462005095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462005096 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462005097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462005098 DNA binding residues [nucleotide binding] 446462005099 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 446462005100 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 446462005101 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 446462005102 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446462005103 NAD binding site [chemical binding]; other site 446462005104 substrate binding site [chemical binding]; other site 446462005105 catalytic Zn binding site [ion binding]; other site 446462005106 tetramer interface [polypeptide binding]; other site 446462005107 structural Zn binding site [ion binding]; other site 446462005108 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446462005109 dimer interface [polypeptide binding]; other site 446462005110 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462005111 GAF domain; Region: GAF; pfam01590 446462005112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462005113 Histidine kinase; Region: HisKA_3; pfam07730 446462005114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005115 ATP binding site [chemical binding]; other site 446462005116 Mg2+ binding site [ion binding]; other site 446462005117 G-X-G motif; other site 446462005118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462005119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005120 active site 446462005121 phosphorylation site [posttranslational modification] 446462005122 intermolecular recognition site; other site 446462005123 dimerization interface [polypeptide binding]; other site 446462005124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462005125 DNA binding residues [nucleotide binding] 446462005126 dimerization interface [polypeptide binding]; other site 446462005127 CBS domain; Region: CBS; pfam00571 446462005128 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446462005129 Ligand Binding Site [chemical binding]; other site 446462005130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462005131 Coenzyme A binding pocket [chemical binding]; other site 446462005132 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446462005133 CoA binding domain; Region: CoA_binding_2; pfam13380 446462005134 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446462005135 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446462005136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446462005137 Ligand Binding Site [chemical binding]; other site 446462005138 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 446462005139 30S subunit binding site; other site 446462005140 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446462005141 putative phosphoketolase; Provisional; Region: PRK05261 446462005142 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 446462005143 TPP-binding site; other site 446462005144 XFP C-terminal domain; Region: XFP_C; pfam09363 446462005145 Acetokinase family; Region: Acetate_kinase; cl17229 446462005146 propionate/acetate kinase; Provisional; Region: PRK12379 446462005147 Acetokinase family; Region: Acetate_kinase; cl17229 446462005148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462005149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462005150 active site 446462005151 ATP binding site [chemical binding]; other site 446462005152 substrate binding site [chemical binding]; other site 446462005153 activation loop (A-loop); other site 446462005154 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 446462005155 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462005156 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462005157 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462005158 active site 446462005159 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 446462005160 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462005161 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462005162 DNA binding site [nucleotide binding] 446462005163 domain linker motif; other site 446462005164 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462005165 ligand binding site [chemical binding]; other site 446462005166 dimerization interface [polypeptide binding]; other site 446462005167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462005168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462005169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005170 dimer interface [polypeptide binding]; other site 446462005171 conserved gate region; other site 446462005172 putative PBP binding loops; other site 446462005173 ABC-ATPase subunit interface; other site 446462005174 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462005175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005176 dimer interface [polypeptide binding]; other site 446462005177 conserved gate region; other site 446462005178 putative PBP binding loops; other site 446462005179 ABC-ATPase subunit interface; other site 446462005180 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446462005181 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446462005182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462005183 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462005184 NAD(P) binding site [chemical binding]; other site 446462005185 active site 446462005186 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446462005187 hydrophobic ligand binding site; other site 446462005188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462005189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005190 active site 446462005191 phosphorylation site [posttranslational modification] 446462005192 intermolecular recognition site; other site 446462005193 dimerization interface [polypeptide binding]; other site 446462005194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462005195 DNA binding site [nucleotide binding] 446462005196 Universal stress protein family; Region: Usp; pfam00582 446462005197 Universal stress protein family; Region: Usp; pfam00582 446462005198 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446462005199 Ligand Binding Site [chemical binding]; other site 446462005200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462005201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005202 active site 446462005203 phosphorylation site [posttranslational modification] 446462005204 intermolecular recognition site; other site 446462005205 dimerization interface [polypeptide binding]; other site 446462005206 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462005207 DNA binding residues [nucleotide binding] 446462005208 dimerization interface [polypeptide binding]; other site 446462005209 Histidine kinase; Region: HisKA_3; pfam07730 446462005210 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462005211 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446462005212 Walker A/P-loop; other site 446462005213 ATP binding site [chemical binding]; other site 446462005214 Q-loop/lid; other site 446462005215 ABC transporter signature motif; other site 446462005216 Walker B; other site 446462005217 D-loop; other site 446462005218 H-loop/switch region; other site 446462005219 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462005220 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462005221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462005222 non-specific DNA binding site [nucleotide binding]; other site 446462005223 salt bridge; other site 446462005224 sequence-specific DNA binding site [nucleotide binding]; other site 446462005225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462005226 S-adenosylmethionine binding site [chemical binding]; other site 446462005227 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446462005228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462005229 Walker A/P-loop; other site 446462005230 ATP binding site [chemical binding]; other site 446462005231 Q-loop/lid; other site 446462005232 ABC transporter signature motif; other site 446462005233 Walker B; other site 446462005234 D-loop; other site 446462005235 H-loop/switch region; other site 446462005236 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 446462005237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005238 putative PBP binding loops; other site 446462005239 ABC-ATPase subunit interface; other site 446462005240 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 446462005241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446462005242 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446462005243 DNA binding residues [nucleotide binding] 446462005244 TOBE domain; Region: TOBE; cl01440 446462005245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462005246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462005248 putative substrate translocation pore; other site 446462005249 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 446462005250 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 446462005251 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 446462005252 Ligand Binding Site [chemical binding]; other site 446462005253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462005254 dimer interface [polypeptide binding]; other site 446462005255 phosphorylation site [posttranslational modification] 446462005256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005257 ATP binding site [chemical binding]; other site 446462005258 Mg2+ binding site [ion binding]; other site 446462005259 G-X-G motif; other site 446462005260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462005261 PAS fold; Region: PAS_3; pfam08447 446462005262 putative active site [active] 446462005263 heme pocket [chemical binding]; other site 446462005264 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462005265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462005266 dimer interface [polypeptide binding]; other site 446462005267 putative CheW interface [polypeptide binding]; other site 446462005268 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446462005269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462005270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462005271 active site 446462005272 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446462005273 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 446462005274 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462005275 Cytochrome P450; Region: p450; cl12078 446462005276 Cytochrome P450; Region: p450; cl12078 446462005277 NAD-dependent deacetylase; Provisional; Region: PRK05333 446462005278 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446462005279 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462005280 MarR family; Region: MarR; pfam01047 446462005281 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446462005282 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462005283 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462005284 DNA binding residues [nucleotide binding] 446462005285 dimerization interface [polypeptide binding]; other site 446462005286 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446462005287 active site 446462005288 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 446462005289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005290 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 446462005291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462005292 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446462005293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462005294 S-adenosylmethionine binding site [chemical binding]; other site 446462005295 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 446462005296 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 446462005297 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446462005298 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446462005299 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446462005300 Protein of unknown function, DUF624; Region: DUF624; cl02369 446462005301 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 446462005302 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462005303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462005304 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462005305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005306 ABC-ATPase subunit interface; other site 446462005307 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446462005308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005309 dimer interface [polypeptide binding]; other site 446462005310 conserved gate region; other site 446462005311 putative PBP binding loops; other site 446462005312 ABC-ATPase subunit interface; other site 446462005313 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 446462005314 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446462005315 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446462005316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462005317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462005318 DNA binding site [nucleotide binding] 446462005319 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 446462005320 putative dimerization interface [polypeptide binding]; other site 446462005321 putative ligand binding site [chemical binding]; other site 446462005322 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 446462005323 Clp amino terminal domain; Region: Clp_N; pfam02861 446462005324 Clp amino terminal domain; Region: Clp_N; pfam02861 446462005325 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 446462005326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462005327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005328 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 446462005329 Phosphotransferase enzyme family; Region: APH; pfam01636 446462005330 active site 446462005331 ATP binding site [chemical binding]; other site 446462005332 antibiotic binding site [chemical binding]; other site 446462005333 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446462005334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462005335 active site 446462005336 motif I; other site 446462005337 motif II; other site 446462005338 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446462005339 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446462005340 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446462005341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 446462005342 NAD(P) binding site [chemical binding]; other site 446462005343 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462005344 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 446462005345 inhibitor-cofactor binding pocket; inhibition site 446462005346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462005347 catalytic residue [active] 446462005348 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 446462005349 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 446462005350 active site 446462005351 homotetramer interface [polypeptide binding]; other site 446462005352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462005353 NAD(P) binding site [chemical binding]; other site 446462005354 active site 446462005355 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446462005356 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 446462005357 active site 446462005358 dimer interface [polypeptide binding]; other site 446462005359 metal binding site [ion binding]; metal-binding site 446462005360 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 446462005361 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446462005362 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446462005363 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 446462005364 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462005365 active site 446462005366 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 446462005367 N-terminal domain interface [polypeptide binding]; other site 446462005368 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446462005369 dimer interface [polypeptide binding]; other site 446462005370 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462005371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462005372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005373 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446462005374 active site 446462005375 isocitrate lyase; Provisional; Region: PRK15063 446462005376 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446462005377 tetramer interface [polypeptide binding]; other site 446462005378 active site 446462005379 Mg2+/Mn2+ binding site [ion binding]; other site 446462005380 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462005381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462005382 sequence-specific DNA binding site [nucleotide binding]; other site 446462005383 salt bridge; other site 446462005384 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 446462005385 Domain of unknown function (DUF955); Region: DUF955; pfam06114 446462005386 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 446462005387 Cytochrome P450; Region: p450; cl12078 446462005388 Histidine kinase; Region: HisKA_3; pfam07730 446462005389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005390 ATP binding site [chemical binding]; other site 446462005391 Mg2+ binding site [ion binding]; other site 446462005392 G-X-G motif; other site 446462005393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462005394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005395 active site 446462005396 phosphorylation site [posttranslational modification] 446462005397 intermolecular recognition site; other site 446462005398 dimerization interface [polypeptide binding]; other site 446462005399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462005400 DNA binding residues [nucleotide binding] 446462005401 dimerization interface [polypeptide binding]; other site 446462005402 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 446462005403 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462005404 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462005405 calcium binding site 2 [ion binding]; other site 446462005406 active site 446462005407 catalytic triad [active] 446462005408 calcium binding site 1 [ion binding]; other site 446462005409 hypothetical protein; Provisional; Region: PRK06834 446462005410 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 446462005411 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462005412 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 446462005413 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 446462005414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462005415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462005416 DNA binding residues [nucleotide binding] 446462005417 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 446462005418 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 446462005419 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 446462005420 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446462005421 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462005422 inhibitor-cofactor binding pocket; inhibition site 446462005423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462005424 catalytic residue [active] 446462005425 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 446462005426 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462005427 kynureninase; Region: kynureninase; TIGR01814 446462005428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462005429 catalytic residue [active] 446462005430 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446462005431 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462005432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462005433 putative substrate translocation pore; other site 446462005434 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 446462005435 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462005436 substrate binding pocket [chemical binding]; other site 446462005437 membrane-bound complex binding site; other site 446462005438 hinge residues; other site 446462005439 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 446462005440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462005441 Walker A/P-loop; other site 446462005442 ATP binding site [chemical binding]; other site 446462005443 ABC transporter; Region: ABC_tran; pfam00005 446462005444 Q-loop/lid; other site 446462005445 ABC transporter signature motif; other site 446462005446 Walker B; other site 446462005447 D-loop; other site 446462005448 H-loop/switch region; other site 446462005449 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 446462005450 Catalytic site [active] 446462005451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462005452 non-specific DNA binding site [nucleotide binding]; other site 446462005453 salt bridge; other site 446462005454 sequence-specific DNA binding site [nucleotide binding]; other site 446462005455 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 446462005456 hypothetical protein; Provisional; Region: PRK07236 446462005457 hypothetical protein; Provisional; Region: PRK07588 446462005458 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 446462005459 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 446462005460 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 446462005461 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 446462005462 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 446462005463 [4Fe-4S] binding site [ion binding]; other site 446462005464 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446462005465 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446462005466 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446462005467 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 446462005468 molybdopterin cofactor binding site; other site 446462005469 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 446462005470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462005471 putative substrate translocation pore; other site 446462005472 argininosuccinate synthase; Validated; Region: PRK05370 446462005473 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 446462005474 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 446462005475 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446462005476 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 446462005477 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446462005478 Interdomain contacts; other site 446462005479 Cytokine receptor motif; other site 446462005480 Cellulose binding domain; Region: CBM_2; pfam00553 446462005481 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 446462005482 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 446462005483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005484 dimer interface [polypeptide binding]; other site 446462005485 conserved gate region; other site 446462005486 ABC-ATPase subunit interface; other site 446462005487 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446462005488 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 446462005489 Walker A/P-loop; other site 446462005490 ATP binding site [chemical binding]; other site 446462005491 Q-loop/lid; other site 446462005492 ABC transporter signature motif; other site 446462005493 Walker B; other site 446462005494 D-loop; other site 446462005495 H-loop/switch region; other site 446462005496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005497 putative PBP binding loops; other site 446462005498 dimer interface [polypeptide binding]; other site 446462005499 ABC-ATPase subunit interface; other site 446462005500 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462005501 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 446462005502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462005504 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446462005505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462005506 Walker A/P-loop; other site 446462005507 ATP binding site [chemical binding]; other site 446462005508 Q-loop/lid; other site 446462005509 ABC transporter signature motif; other site 446462005510 Walker B; other site 446462005511 D-loop; other site 446462005512 H-loop/switch region; other site 446462005513 TOBE domain; Region: TOBE_2; pfam08402 446462005514 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 446462005515 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446462005516 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446462005517 nucleoside/Zn binding site; other site 446462005518 dimer interface [polypeptide binding]; other site 446462005519 catalytic motif [active] 446462005520 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 446462005521 active site 446462005522 homotetramer interface [polypeptide binding]; other site 446462005523 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446462005524 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462005525 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 446462005526 Nitrate and nitrite sensing; Region: NIT; pfam08376 446462005527 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462005528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005529 ATP binding site [chemical binding]; other site 446462005530 Mg2+ binding site [ion binding]; other site 446462005531 G-X-G motif; other site 446462005532 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446462005533 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446462005534 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446462005535 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446462005536 G1 box; other site 446462005537 GTP/Mg2+ binding site [chemical binding]; other site 446462005538 G2 box; other site 446462005539 Switch I region; other site 446462005540 G3 box; other site 446462005541 Switch II region; other site 446462005542 G4 box; other site 446462005543 G5 box; other site 446462005544 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446462005545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462005546 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 446462005547 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 446462005548 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 446462005549 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462005550 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462005551 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 446462005552 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446462005553 ethanolamine permease; Region: 2A0305; TIGR00908 446462005554 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446462005555 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446462005556 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446462005557 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 446462005558 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446462005559 conserved cys residue [active] 446462005560 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446462005561 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462005562 NAD(P) binding site [chemical binding]; other site 446462005563 catalytic residues [active] 446462005564 short chain dehydrogenase; Provisional; Region: PRK06057 446462005565 classical (c) SDRs; Region: SDR_c; cd05233 446462005566 NAD(P) binding site [chemical binding]; other site 446462005567 active site 446462005568 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446462005569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462005570 DNA-binding site [nucleotide binding]; DNA binding site 446462005571 FCD domain; Region: FCD; pfam07729 446462005572 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446462005573 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446462005574 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462005576 Walker A/P-loop; other site 446462005577 ATP binding site [chemical binding]; other site 446462005578 Q-loop/lid; other site 446462005579 ABC transporter signature motif; other site 446462005580 Walker B; other site 446462005581 D-loop; other site 446462005582 H-loop/switch region; other site 446462005583 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 446462005584 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 446462005585 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 446462005586 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 446462005587 active site 446462005588 dimer interface [polypeptide binding]; other site 446462005589 motif 1; other site 446462005590 motif 2; other site 446462005591 motif 3; other site 446462005592 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 446462005593 anticodon binding site; other site 446462005594 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 446462005595 nucleotide binding site/active site [active] 446462005596 HIT family signature motif; other site 446462005597 catalytic residue [active] 446462005598 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446462005599 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 446462005600 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 446462005601 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 446462005602 putative acyl-acceptor binding pocket; other site 446462005603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462005604 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462005605 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 446462005606 nudix motif; other site 446462005607 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 446462005608 pentamer interface [polypeptide binding]; other site 446462005609 dodecaamer interface [polypeptide binding]; other site 446462005610 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 446462005611 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462005612 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 446462005613 phenylhydantoinase; Validated; Region: PRK08323 446462005614 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 446462005615 tetramer interface [polypeptide binding]; other site 446462005616 active site 446462005617 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446462005618 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446462005619 active site 446462005620 catalytic triad [active] 446462005621 dimer interface [polypeptide binding]; other site 446462005622 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 446462005623 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 446462005624 Na binding site [ion binding]; other site 446462005625 putative substrate binding site [chemical binding]; other site 446462005626 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446462005627 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462005628 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 446462005629 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462005630 inhibitor-cofactor binding pocket; inhibition site 446462005631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462005632 catalytic residue [active] 446462005633 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 446462005634 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 446462005635 tetrameric interface [polypeptide binding]; other site 446462005636 NAD binding site [chemical binding]; other site 446462005637 catalytic residues [active] 446462005638 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446462005639 elongation factor G; Reviewed; Region: PRK12740 446462005640 G1 box; other site 446462005641 GTP/Mg2+ binding site [chemical binding]; other site 446462005642 G2 box; other site 446462005643 Switch I region; other site 446462005644 G3 box; other site 446462005645 Switch II region; other site 446462005646 G4 box; other site 446462005647 G5 box; other site 446462005648 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446462005649 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446462005650 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446462005651 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 446462005652 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 446462005653 active site 446462005654 multimer interface [polypeptide binding]; other site 446462005655 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 446462005656 predicted active site [active] 446462005657 catalytic triad [active] 446462005658 hypothetical protein; Validated; Region: PRK00110 446462005659 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 446462005660 TIGR03086 family protein; Region: TIGR03086 446462005661 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446462005662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005663 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446462005664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462005665 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462005666 Cytochrome P450; Region: p450; cl12078 446462005667 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462005668 Cytochrome P450; Region: p450; cl12078 446462005669 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462005670 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005671 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446462005672 active site 446462005673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462005674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005675 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446462005676 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 446462005677 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446462005678 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 446462005679 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 446462005680 putative active site [active] 446462005681 putative dimer interface [polypeptide binding]; other site 446462005682 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 446462005683 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 446462005684 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462005685 non-specific DNA binding site [nucleotide binding]; other site 446462005686 salt bridge; other site 446462005687 sequence-specific DNA binding site [nucleotide binding]; other site 446462005688 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462005689 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446462005690 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446462005691 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446462005692 aconitate hydratase; Validated; Region: PRK09277 446462005693 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446462005694 substrate binding site [chemical binding]; other site 446462005695 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446462005696 ligand binding site [chemical binding]; other site 446462005697 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 446462005698 substrate binding site [chemical binding]; other site 446462005699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462005700 Walker A/P-loop; other site 446462005701 ATP binding site [chemical binding]; other site 446462005702 ABC transporter; Region: ABC_tran; pfam00005 446462005703 Q-loop/lid; other site 446462005704 ABC transporter signature motif; other site 446462005705 Walker B; other site 446462005706 NAD-dependent deacetylase; Provisional; Region: PRK00481 446462005707 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 446462005708 NAD+ binding site [chemical binding]; other site 446462005709 substrate binding site [chemical binding]; other site 446462005710 Zn binding site [ion binding]; other site 446462005711 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 446462005712 active site 446462005713 zinc binding site [ion binding]; other site 446462005714 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 446462005715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462005716 acyl-activating enzyme (AAE) consensus motif; other site 446462005717 AMP binding site [chemical binding]; other site 446462005718 active site 446462005719 CoA binding site [chemical binding]; other site 446462005720 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446462005721 NlpC/P60 family; Region: NLPC_P60; pfam00877 446462005722 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462005723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462005724 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462005725 DNA binding residues [nucleotide binding] 446462005726 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 446462005727 active site 446462005728 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 446462005729 MoxR-like ATPases [General function prediction only]; Region: COG0714 446462005730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446462005731 Protein of unknown function DUF58; Region: DUF58; pfam01882 446462005732 hypothetical protein; Provisional; Region: PRK13685 446462005733 Aerotolerance regulator N-terminal; Region: BatA; cl06567 446462005734 von Willebrand factor type A domain; Region: VWA_2; pfam13519 446462005735 metal ion-dependent adhesion site (MIDAS); other site 446462005736 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 446462005737 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 446462005738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462005739 dimerization interface [polypeptide binding]; other site 446462005740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462005741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005742 ATP binding site [chemical binding]; other site 446462005743 Mg2+ binding site [ion binding]; other site 446462005744 G-X-G motif; other site 446462005745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462005746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005747 active site 446462005748 phosphorylation site [posttranslational modification] 446462005749 intermolecular recognition site; other site 446462005750 dimerization interface [polypeptide binding]; other site 446462005751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462005752 DNA binding site [nucleotide binding] 446462005753 GAF domain; Region: GAF; cl17456 446462005754 ANTAR domain; Region: ANTAR; pfam03861 446462005755 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446462005756 mce related protein; Region: MCE; pfam02470 446462005757 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 446462005758 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446462005759 mce related protein; Region: MCE; pfam02470 446462005760 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446462005761 mce related protein; Region: MCE; pfam02470 446462005762 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446462005763 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446462005764 mce related protein; Region: MCE; pfam02470 446462005765 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 446462005766 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446462005767 Uncharacterized protein conserved in bacteria, putative virulence factor [Function unknown]; Region: SrfB; COG4457 446462005768 Phosphotransferase enzyme family; Region: APH; pfam01636 446462005769 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446462005770 active site 446462005771 ATP binding site [chemical binding]; other site 446462005772 substrate binding site [chemical binding]; other site 446462005773 hypothetical protein; Provisional; Region: PRK04233 446462005774 SEC-C motif; Region: SEC-C; pfam02810 446462005775 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446462005776 Cellulose binding domain; Region: CBM_2; cl17741 446462005777 Cellulose binding domain; Region: CBM_2; pfam00553 446462005778 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 446462005779 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 446462005780 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462005781 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446462005782 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 446462005783 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446462005784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462005785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462005786 DNA binding site [nucleotide binding] 446462005787 domain linker motif; other site 446462005788 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462005789 dimerization interface [polypeptide binding]; other site 446462005790 ligand binding site [chemical binding]; other site 446462005791 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462005792 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446462005793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005794 dimer interface [polypeptide binding]; other site 446462005795 conserved gate region; other site 446462005796 ABC-ATPase subunit interface; other site 446462005797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462005798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462005799 dimer interface [polypeptide binding]; other site 446462005800 conserved gate region; other site 446462005801 putative PBP binding loops; other site 446462005802 ABC-ATPase subunit interface; other site 446462005803 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446462005804 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446462005805 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446462005806 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 446462005807 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446462005808 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462005809 DNA binding residues [nucleotide binding] 446462005810 putative dimer interface [polypeptide binding]; other site 446462005811 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446462005812 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446462005813 FAD binding domain; Region: FAD_binding_4; pfam01565 446462005814 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 446462005815 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 446462005816 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 446462005817 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446462005818 NAD(P) binding site [chemical binding]; other site 446462005819 homotetramer interface [polypeptide binding]; other site 446462005820 homodimer interface [polypeptide binding]; other site 446462005821 active site 446462005822 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 446462005823 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 446462005824 NAD binding site [chemical binding]; other site 446462005825 homotetramer interface [polypeptide binding]; other site 446462005826 homodimer interface [polypeptide binding]; other site 446462005827 substrate binding site [chemical binding]; other site 446462005828 active site 446462005829 ferrochelatase; Reviewed; Region: hemH; PRK00035 446462005830 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 446462005831 C-terminal domain interface [polypeptide binding]; other site 446462005832 active site 446462005833 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 446462005834 active site 446462005835 N-terminal domain interface [polypeptide binding]; other site 446462005836 YcxB-like protein; Region: YcxB; pfam14317 446462005837 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446462005838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462005839 NAD(P) binding site [chemical binding]; other site 446462005840 active site 446462005841 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 446462005842 EspG family; Region: ESX-1_EspG; pfam14011 446462005843 Cellulose binding domain; Region: CBM_2; pfam00553 446462005844 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446462005845 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 446462005846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462005847 Walker A/P-loop; other site 446462005848 ATP binding site [chemical binding]; other site 446462005849 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446462005850 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 446462005851 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446462005852 metal ion-dependent adhesion site (MIDAS); other site 446462005853 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462005854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462005855 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 446462005856 nudix motif; other site 446462005857 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446462005858 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462005859 dimerization interface [polypeptide binding]; other site 446462005860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462005861 dimer interface [polypeptide binding]; other site 446462005862 putative CheW interface [polypeptide binding]; other site 446462005863 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446462005864 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446462005865 D-pathway; other site 446462005866 Putative ubiquinol binding site [chemical binding]; other site 446462005867 Low-spin heme (heme b) binding site [chemical binding]; other site 446462005868 Putative water exit pathway; other site 446462005869 Binuclear center (heme o3/CuB) [ion binding]; other site 446462005870 K-pathway; other site 446462005871 Putative proton exit pathway; other site 446462005872 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462005873 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 446462005874 active site 446462005875 HIGH motif; other site 446462005876 nucleotide binding site [chemical binding]; other site 446462005877 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462005878 active site 446462005879 KMSKS motif; other site 446462005880 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 446462005881 putative tRNA binding surface [nucleotide binding]; other site 446462005882 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462005883 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446462005884 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462005885 calcium binding site 2 [ion binding]; other site 446462005886 active site 446462005887 catalytic triad [active] 446462005888 calcium binding site 1 [ion binding]; other site 446462005889 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 446462005890 MarR family; Region: MarR_2; cl17246 446462005891 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446462005892 Catalytic site [active] 446462005893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462005894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005895 active site 446462005896 phosphorylation site [posttranslational modification] 446462005897 intermolecular recognition site; other site 446462005898 dimerization interface [polypeptide binding]; other site 446462005899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462005900 DNA binding site [nucleotide binding] 446462005901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005902 Response regulator receiver domain; Region: Response_reg; pfam00072 446462005903 active site 446462005904 phosphorylation site [posttranslational modification] 446462005905 intermolecular recognition site; other site 446462005906 dimerization interface [polypeptide binding]; other site 446462005907 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462005908 GAF domain; Region: GAF; pfam01590 446462005909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462005910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462005911 dimer interface [polypeptide binding]; other site 446462005912 phosphorylation site [posttranslational modification] 446462005913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005914 ATP binding site [chemical binding]; other site 446462005915 Mg2+ binding site [ion binding]; other site 446462005916 G-X-G motif; other site 446462005917 PAC2 family; Region: PAC2; pfam09754 446462005918 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 446462005919 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 446462005920 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 446462005921 substrate binding pocket [chemical binding]; other site 446462005922 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 446462005923 B12 binding site [chemical binding]; other site 446462005924 cobalt ligand [ion binding]; other site 446462005925 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 446462005926 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 446462005927 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446462005928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462005929 motif II; other site 446462005930 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 446462005931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462005932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462005933 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446462005934 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446462005935 phosphate binding site [ion binding]; other site 446462005936 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 446462005937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462005938 NAD(P) binding site [chemical binding]; other site 446462005939 active site 446462005940 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 446462005941 homodimer interface [polypeptide binding]; other site 446462005942 putative metal binding site [ion binding]; other site 446462005943 Predicted permeases [General function prediction only]; Region: COG0679 446462005944 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 446462005945 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 446462005946 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 446462005947 active site 446462005948 Peptidase family M50; Region: Peptidase_M50; pfam02163 446462005949 putative substrate binding region [chemical binding]; other site 446462005950 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462005951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005952 active site 446462005953 phosphorylation site [posttranslational modification] 446462005954 intermolecular recognition site; other site 446462005955 dimerization interface [polypeptide binding]; other site 446462005956 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462005957 DNA binding residues [nucleotide binding] 446462005958 dimerization interface [polypeptide binding]; other site 446462005959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462005960 Histidine kinase; Region: HisKA_3; pfam07730 446462005961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462005962 ATP binding site [chemical binding]; other site 446462005963 Mg2+ binding site [ion binding]; other site 446462005964 G-X-G motif; other site 446462005965 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 446462005966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462005967 S-adenosylmethionine binding site [chemical binding]; other site 446462005968 SnoaL-like domain; Region: SnoaL_3; pfam13474 446462005969 proteasome ATPase; Region: pup_AAA; TIGR03689 446462005970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462005971 Walker A motif; other site 446462005972 ATP binding site [chemical binding]; other site 446462005973 Walker B motif; other site 446462005974 arginine finger; other site 446462005975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462005976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462005977 active site 446462005978 phosphorylation site [posttranslational modification] 446462005979 intermolecular recognition site; other site 446462005980 dimerization interface [polypeptide binding]; other site 446462005981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462005982 DNA binding residues [nucleotide binding] 446462005983 dimerization interface [polypeptide binding]; other site 446462005984 Histidine kinase; Region: HisKA_3; pfam07730 446462005985 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462005986 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462005987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462005988 Walker A/P-loop; other site 446462005989 ATP binding site [chemical binding]; other site 446462005990 Q-loop/lid; other site 446462005991 ABC transporter signature motif; other site 446462005992 Walker B; other site 446462005993 D-loop; other site 446462005994 H-loop/switch region; other site 446462005995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 446462005996 active site 446462005997 catalytic tetrad [active] 446462005998 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446462005999 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 446462006000 nudix motif; other site 446462006001 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446462006002 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 446462006003 Pup-like protein; Region: Pup; pfam05639 446462006004 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 446462006005 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 446462006006 active site 446462006007 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 446462006008 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446462006009 active site 446462006010 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446462006011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462006012 NAD(P) binding site [chemical binding]; other site 446462006013 active site 446462006014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006015 AAA ATPase domain; Region: AAA_16; pfam13191 446462006016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462006017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462006018 DNA binding residues [nucleotide binding] 446462006019 dimerization interface [polypeptide binding]; other site 446462006020 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446462006021 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 446462006022 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446462006023 hydrophobic ligand binding site; other site 446462006024 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446462006025 hydrophobic ligand binding site; other site 446462006026 Predicted transcriptional regulator [Transcription]; Region: COG2378 446462006027 WYL domain; Region: WYL; pfam13280 446462006028 WYL domain; Region: WYL; pfam13280 446462006029 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 446462006030 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 446462006031 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 446462006032 diacylglycerol kinase; Reviewed; Region: PRK11914 446462006033 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446462006034 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 446462006035 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462006036 ATP binding site [chemical binding]; other site 446462006037 putative Mg++ binding site [ion binding]; other site 446462006038 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462006039 nucleotide binding region [chemical binding]; other site 446462006040 ATP-binding site [chemical binding]; other site 446462006041 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 446462006042 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 446462006043 hypothetical protein; Provisional; Region: PRK01346 446462006044 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 446462006045 5'-3' exonuclease; Region: 53EXOc; smart00475 446462006046 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446462006047 active site 446462006048 metal binding site 1 [ion binding]; metal-binding site 446462006049 putative 5' ssDNA interaction site; other site 446462006050 metal binding site 3; metal-binding site 446462006051 metal binding site 2 [ion binding]; metal-binding site 446462006052 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446462006053 putative DNA binding site [nucleotide binding]; other site 446462006054 putative metal binding site [ion binding]; other site 446462006055 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 446462006056 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 446462006057 active site 446462006058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462006059 putative DNA binding site [nucleotide binding]; other site 446462006060 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446462006061 putative Zn2+ binding site [ion binding]; other site 446462006062 AsnC family; Region: AsnC_trans_reg; pfam01037 446462006063 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 446462006064 substrate-cofactor binding pocket; other site 446462006065 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462006066 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462006067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462006068 metal binding site [ion binding]; metal-binding site 446462006069 active site 446462006070 I-site; other site 446462006071 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462006072 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462006073 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 446462006074 AIPR protein; Region: AIPR; pfam10592 446462006075 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462006076 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462006077 catalytic residue [active] 446462006078 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 446462006079 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446462006080 ATP binding site [chemical binding]; other site 446462006081 Mg++ binding site [ion binding]; other site 446462006082 motif III; other site 446462006083 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462006084 nucleotide binding region [chemical binding]; other site 446462006085 ATP-binding site [chemical binding]; other site 446462006086 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 446462006087 RNA binding site [nucleotide binding]; other site 446462006088 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446462006089 synthetase active site [active] 446462006090 NTP binding site [chemical binding]; other site 446462006091 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446462006092 metal binding site [ion binding]; metal-binding site 446462006093 Uncharacterized conserved protein [Function unknown]; Region: COG2353 446462006094 MarR family; Region: MarR_2; pfam12802 446462006095 MoxR-like ATPases [General function prediction only]; Region: COG0714 446462006096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446462006097 Walker A motif; other site 446462006098 ATP binding site [chemical binding]; other site 446462006099 Walker B motif; other site 446462006100 arginine finger; other site 446462006101 Protein of unknown function DUF58; Region: DUF58; pfam01882 446462006102 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 446462006103 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 446462006104 active site 446462006105 acyl-activating enzyme (AAE) consensus motif; other site 446462006106 putative CoA binding site [chemical binding]; other site 446462006107 AMP binding site [chemical binding]; other site 446462006108 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 446462006109 B12 binding site [chemical binding]; other site 446462006110 cobalt ligand [ion binding]; other site 446462006111 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446462006112 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 446462006113 TPR repeat; Region: TPR_11; pfam13414 446462006114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462006115 binding surface 446462006116 TPR motif; other site 446462006117 Tetratricopeptide repeat; Region: TPR_16; pfam13432 446462006118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462006119 binding surface 446462006120 Tetratricopeptide repeat; Region: TPR_16; pfam13432 446462006121 TPR motif; other site 446462006122 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 446462006123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006124 ATP binding site [chemical binding]; other site 446462006125 Mg2+ binding site [ion binding]; other site 446462006126 G-X-G motif; other site 446462006127 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446462006128 anchoring element; other site 446462006129 dimer interface [polypeptide binding]; other site 446462006130 ATP binding site [chemical binding]; other site 446462006131 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446462006132 active site 446462006133 metal binding site [ion binding]; metal-binding site 446462006134 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446462006135 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 446462006136 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 446462006137 protein-splicing catalytic site; other site 446462006138 thioester formation/cholesterol transfer; other site 446462006139 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 446462006140 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446462006141 CAP-like domain; other site 446462006142 active site 446462006143 primary dimer interface [polypeptide binding]; other site 446462006144 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446462006145 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 446462006146 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446462006147 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462006148 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462006149 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446462006150 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 446462006151 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 446462006152 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 446462006153 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 446462006154 PAS fold; Region: PAS; pfam00989 446462006155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462006156 putative active site [active] 446462006157 heme pocket [chemical binding]; other site 446462006158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462006159 metal binding site [ion binding]; metal-binding site 446462006160 active site 446462006161 I-site; other site 446462006162 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462006163 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 446462006164 putative hydrophobic ligand binding site [chemical binding]; other site 446462006165 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446462006166 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446462006167 Walker A/P-loop; other site 446462006168 ATP binding site [chemical binding]; other site 446462006169 Q-loop/lid; other site 446462006170 ABC transporter signature motif; other site 446462006171 Walker B; other site 446462006172 D-loop; other site 446462006173 H-loop/switch region; other site 446462006174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462006175 Walker A/P-loop; other site 446462006176 ATP binding site [chemical binding]; other site 446462006177 Q-loop/lid; other site 446462006178 ABC transporter signature motif; other site 446462006179 Walker B; other site 446462006180 D-loop; other site 446462006181 H-loop/switch region; other site 446462006182 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 446462006183 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 446462006184 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 446462006185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462006186 S-adenosylmethionine binding site [chemical binding]; other site 446462006187 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462006188 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462006189 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462006190 Mg2+ binding site [ion binding]; other site 446462006191 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462006192 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462006193 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462006194 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462006195 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462006196 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446462006197 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446462006198 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 446462006199 FAD binding domain; Region: FAD_binding_4; pfam01565 446462006200 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446462006201 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462006202 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462006203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006204 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462006205 anti sigma factor interaction site; other site 446462006206 regulatory phosphorylation site [posttranslational modification]; other site 446462006207 putative methyltransferase; Provisional; Region: PRK14967 446462006208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462006209 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 446462006210 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446462006211 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446462006212 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446462006213 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446462006214 PAS fold; Region: PAS_3; pfam08447 446462006215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462006216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462006217 dimer interface [polypeptide binding]; other site 446462006218 phosphorylation site [posttranslational modification] 446462006219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006220 ATP binding site [chemical binding]; other site 446462006221 Mg2+ binding site [ion binding]; other site 446462006222 G-X-G motif; other site 446462006223 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 446462006224 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 446462006225 FHIPEP family; Region: FHIPEP; pfam00771 446462006226 Response regulator receiver domain; Region: Response_reg; pfam00072 446462006227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006228 active site 446462006229 phosphorylation site [posttranslational modification] 446462006230 intermolecular recognition site; other site 446462006231 dimerization interface [polypeptide binding]; other site 446462006232 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 446462006233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006234 Response regulator receiver domain; Region: Response_reg; pfam00072 446462006235 active site 446462006236 phosphorylation site [posttranslational modification] 446462006237 intermolecular recognition site; other site 446462006238 dimerization interface [polypeptide binding]; other site 446462006239 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 446462006240 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 446462006241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462006242 S-adenosylmethionine binding site [chemical binding]; other site 446462006243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006244 active site 446462006245 phosphorylation site [posttranslational modification] 446462006246 intermolecular recognition site; other site 446462006247 dimerization interface [polypeptide binding]; other site 446462006248 CheB methylesterase; Region: CheB_methylest; pfam01339 446462006249 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 446462006250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462006251 dimerization interface [polypeptide binding]; other site 446462006252 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462006253 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462006254 dimer interface [polypeptide binding]; other site 446462006255 putative CheW interface [polypeptide binding]; other site 446462006256 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 446462006257 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 446462006258 putative binding surface; other site 446462006259 active site 446462006260 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 446462006261 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 446462006262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006263 ATP binding site [chemical binding]; other site 446462006264 Mg2+ binding site [ion binding]; other site 446462006265 G-X-G motif; other site 446462006266 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 446462006267 CheW-like domain; Region: CheW; pfam01584 446462006268 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 446462006269 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 446462006270 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 446462006271 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 446462006272 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 446462006273 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 446462006274 flagellar motor switch protein FliN; Region: fliN; TIGR02480 446462006275 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 446462006276 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 446462006277 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 446462006278 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 446462006279 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 446462006280 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446462006281 ligand binding site [chemical binding]; other site 446462006282 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 446462006283 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 446462006284 Flagellar protein (FlbD); Region: FlbD; pfam06289 446462006285 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 446462006286 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 446462006287 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 446462006288 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 446462006289 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 446462006290 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 446462006291 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446462006292 NlpC/P60 family; Region: NLPC_P60; pfam00877 446462006293 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 446462006294 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446462006295 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446462006296 catalytic residue [active] 446462006297 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 446462006298 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446462006299 Walker A motif; other site 446462006300 ATP binding site [chemical binding]; other site 446462006301 Walker B motif; other site 446462006302 Flagellar assembly protein FliH; Region: FliH; pfam02108 446462006303 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 446462006304 FliG C-terminal domain; Region: FliG_C; pfam01706 446462006305 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 446462006306 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 446462006307 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 446462006308 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 446462006309 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 446462006310 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 446462006311 flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396 446462006312 Flagellar protein FliS; Region: FliS; cl00654 446462006313 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 446462006314 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 446462006315 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 446462006316 flagellin; Reviewed; Region: PRK08869 446462006317 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 446462006318 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 446462006319 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 446462006320 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462006321 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462006322 DNA binding residues [nucleotide binding] 446462006323 FlgN protein; Region: FlgN; pfam05130 446462006324 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 446462006325 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 446462006326 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 446462006327 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 446462006328 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 446462006329 FliW protein; Region: FliW; pfam02623 446462006330 carbon storage regulator; Provisional; Region: PRK01712 446462006331 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462006332 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462006333 calcium binding site 2 [ion binding]; other site 446462006334 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446462006335 active site 446462006336 catalytic triad [active] 446462006337 calcium binding site 1 [ion binding]; other site 446462006338 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 446462006339 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446462006340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462006341 putative active site [active] 446462006342 heme pocket [chemical binding]; other site 446462006343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462006344 dimer interface [polypeptide binding]; other site 446462006345 phosphorylation site [posttranslational modification] 446462006346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006347 ATP binding site [chemical binding]; other site 446462006348 Mg2+ binding site [ion binding]; other site 446462006349 G-X-G motif; other site 446462006350 Response regulator receiver domain; Region: Response_reg; pfam00072 446462006351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006352 active site 446462006353 phosphorylation site [posttranslational modification] 446462006354 intermolecular recognition site; other site 446462006355 dimerization interface [polypeptide binding]; other site 446462006356 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446462006357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006358 active site 446462006359 phosphorylation site [posttranslational modification] 446462006360 intermolecular recognition site; other site 446462006361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462006362 NmrA-like family; Region: NmrA; pfam05368 446462006363 NAD(P) binding site [chemical binding]; other site 446462006364 active site 446462006365 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462006366 MarR family; Region: MarR_2; pfam12802 446462006367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462006368 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 446462006369 putative active site [active] 446462006370 heme pocket [chemical binding]; other site 446462006371 PAS domain; Region: PAS; smart00091 446462006372 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 446462006373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462006374 dimer interface [polypeptide binding]; other site 446462006375 phosphorylation site [posttranslational modification] 446462006376 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462006377 PAS domain; Region: PAS; smart00091 446462006378 PAS domain; Region: PAS_9; pfam13426 446462006379 PAS fold; Region: PAS_4; pfam08448 446462006380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462006381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006382 ATP binding site [chemical binding]; other site 446462006383 Mg2+ binding site [ion binding]; other site 446462006384 G-X-G motif; other site 446462006385 Response regulator receiver domain; Region: Response_reg; pfam00072 446462006386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006387 active site 446462006388 phosphorylation site [posttranslational modification] 446462006389 intermolecular recognition site; other site 446462006390 dimerization interface [polypeptide binding]; other site 446462006391 HDOD domain; Region: HDOD; pfam08668 446462006392 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446462006393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462006394 putative active site [active] 446462006395 heme pocket [chemical binding]; other site 446462006396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462006397 dimer interface [polypeptide binding]; other site 446462006398 phosphorylation site [posttranslational modification] 446462006399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006400 ATP binding site [chemical binding]; other site 446462006401 Mg2+ binding site [ion binding]; other site 446462006402 G-X-G motif; other site 446462006403 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446462006404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006405 active site 446462006406 phosphorylation site [posttranslational modification] 446462006407 intermolecular recognition site; other site 446462006408 dimerization interface [polypeptide binding]; other site 446462006409 Response regulator receiver domain; Region: Response_reg; pfam00072 446462006410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006411 active site 446462006412 phosphorylation site [posttranslational modification] 446462006413 intermolecular recognition site; other site 446462006414 dimerization interface [polypeptide binding]; other site 446462006415 Response regulator receiver domain; Region: Response_reg; pfam00072 446462006416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006417 active site 446462006418 phosphorylation site [posttranslational modification] 446462006419 intermolecular recognition site; other site 446462006420 dimerization interface [polypeptide binding]; other site 446462006421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 446462006422 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446462006423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462006424 DNA-binding site [nucleotide binding]; DNA binding site 446462006425 FCD domain; Region: FCD; pfam07729 446462006426 CHRD domain; Region: CHRD; pfam07452 446462006427 DoxX-like family; Region: DoxX_2; pfam13564 446462006428 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462006429 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446462006430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462006431 salt bridge; other site 446462006432 non-specific DNA binding site [nucleotide binding]; other site 446462006433 sequence-specific DNA binding site [nucleotide binding]; other site 446462006434 short chain dehydrogenase; Provisional; Region: PRK06197 446462006435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462006436 NAD(P) binding site [chemical binding]; other site 446462006437 active site 446462006438 MASE1; Region: MASE1; cl17823 446462006439 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446462006440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462006441 dimer interface [polypeptide binding]; other site 446462006442 phosphorylation site [posttranslational modification] 446462006443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006444 ATP binding site [chemical binding]; other site 446462006445 Mg2+ binding site [ion binding]; other site 446462006446 G-X-G motif; other site 446462006447 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 446462006448 AzlC protein; Region: AzlC; cl00570 446462006449 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462006450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462006451 putative DNA binding site [nucleotide binding]; other site 446462006452 putative Zn2+ binding site [ion binding]; other site 446462006453 AsnC family; Region: AsnC_trans_reg; pfam01037 446462006454 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462006455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462006456 putative substrate translocation pore; other site 446462006457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462006458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006459 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 446462006460 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 446462006461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446462006462 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446462006463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462006464 NAD(P) binding site [chemical binding]; other site 446462006465 active site 446462006466 heat shock protein 90; Provisional; Region: PRK05218 446462006467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006468 ATP binding site [chemical binding]; other site 446462006469 Mg2+ binding site [ion binding]; other site 446462006470 G-X-G motif; other site 446462006471 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462006472 MarR family; Region: MarR_2; pfam12802 446462006473 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446462006474 classical (c) SDRs; Region: SDR_c; cd05233 446462006475 NAD(P) binding site [chemical binding]; other site 446462006476 active site 446462006477 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 446462006478 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446462006479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446462006480 RNA binding surface [nucleotide binding]; other site 446462006481 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 446462006482 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462006483 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446462006484 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446462006485 FAD binding pocket [chemical binding]; other site 446462006486 FAD binding motif [chemical binding]; other site 446462006487 phosphate binding motif [ion binding]; other site 446462006488 NAD binding pocket [chemical binding]; other site 446462006489 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462006490 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462006491 DNA binding site [nucleotide binding] 446462006492 domain linker motif; other site 446462006493 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462006494 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462006495 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462006496 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446462006497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462006498 ABC-ATPase subunit interface; other site 446462006499 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462006500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462006501 dimer interface [polypeptide binding]; other site 446462006502 conserved gate region; other site 446462006503 putative PBP binding loops; other site 446462006504 ABC-ATPase subunit interface; other site 446462006505 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446462006506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462006507 Walker A/P-loop; other site 446462006508 ATP binding site [chemical binding]; other site 446462006509 Q-loop/lid; other site 446462006510 ABC transporter signature motif; other site 446462006511 Walker B; other site 446462006512 D-loop; other site 446462006513 H-loop/switch region; other site 446462006514 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462006515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006516 active site 446462006517 phosphorylation site [posttranslational modification] 446462006518 intermolecular recognition site; other site 446462006519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462006520 DNA binding residues [nucleotide binding] 446462006521 dimerization interface [polypeptide binding]; other site 446462006522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462006523 Histidine kinase; Region: HisKA_3; pfam07730 446462006524 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446462006525 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446462006526 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446462006527 Ligand Binding Site [chemical binding]; other site 446462006528 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 446462006529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462006530 FeS/SAM binding site; other site 446462006531 Pyruvate formate lyase 1; Region: PFL1; cd01678 446462006532 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 446462006533 coenzyme A binding site [chemical binding]; other site 446462006534 active site 446462006535 catalytic residues [active] 446462006536 glycine loop; other site 446462006537 conserved repeat domain; Region: B_ant_repeat; TIGR01451 446462006538 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462006539 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462006540 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006541 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462006542 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006543 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006544 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006545 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006546 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006547 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006548 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006549 Cna protein B-type domain; Region: Cna_B; pfam05738 446462006550 conserved repeat domain; Region: B_ant_repeat; TIGR01451 446462006551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462006552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006553 short chain dehydrogenase; Provisional; Region: PRK06523 446462006554 classical (c) SDRs; Region: SDR_c; cd05233 446462006555 NAD(P) binding site [chemical binding]; other site 446462006556 active site 446462006557 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446462006558 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446462006559 Ion transport protein; Region: Ion_trans; pfam00520 446462006560 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462006561 FAD binding domain; Region: FAD_binding_4; pfam01565 446462006562 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 446462006563 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462006564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462006565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462006566 non-specific DNA binding site [nucleotide binding]; other site 446462006567 salt bridge; other site 446462006568 sequence-specific DNA binding site [nucleotide binding]; other site 446462006569 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 446462006570 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462006571 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446462006572 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446462006573 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 446462006574 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 446462006575 AAA domain; Region: AAA_23; pfam13476 446462006576 Lsr2; Region: Lsr2; pfam11774 446462006577 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 446462006578 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462006579 active site 446462006580 metal binding site [ion binding]; metal-binding site 446462006581 DNA binding site [nucleotide binding] 446462006582 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 446462006583 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 446462006584 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 446462006585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462006586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462006587 salt bridge; other site 446462006588 non-specific DNA binding site [nucleotide binding]; other site 446462006589 sequence-specific DNA binding site [nucleotide binding]; other site 446462006590 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446462006591 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446462006592 FAD binding pocket [chemical binding]; other site 446462006593 FAD binding motif [chemical binding]; other site 446462006594 phosphate binding motif [ion binding]; other site 446462006595 NAD binding pocket [chemical binding]; other site 446462006596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462006597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006598 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462006599 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 446462006600 putative NAD(P) binding site [chemical binding]; other site 446462006601 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462006602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462006603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462006604 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446462006605 putative dimerization interface [polypeptide binding]; other site 446462006606 EamA-like transporter family; Region: EamA; pfam00892 446462006607 Predicted membrane protein [Function unknown]; Region: COG2119 446462006608 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 446462006609 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 446462006610 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 446462006611 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 446462006612 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 446462006613 MarR family; Region: MarR_2; cl17246 446462006614 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 446462006615 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446462006616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462006617 Walker A/P-loop; other site 446462006618 ATP binding site [chemical binding]; other site 446462006619 Q-loop/lid; other site 446462006620 ABC transporter signature motif; other site 446462006621 Walker B; other site 446462006622 D-loop; other site 446462006623 H-loop/switch region; other site 446462006624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462006625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462006626 Walker A/P-loop; other site 446462006627 ATP binding site [chemical binding]; other site 446462006628 Q-loop/lid; other site 446462006629 ABC transporter signature motif; other site 446462006630 Walker B; other site 446462006631 D-loop; other site 446462006632 H-loop/switch region; other site 446462006633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462006634 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462006635 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446462006636 peptide binding site [polypeptide binding]; other site 446462006637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462006638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462006639 dimer interface [polypeptide binding]; other site 446462006640 conserved gate region; other site 446462006641 putative PBP binding loops; other site 446462006642 ABC-ATPase subunit interface; other site 446462006643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462006644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462006645 dimer interface [polypeptide binding]; other site 446462006646 conserved gate region; other site 446462006647 putative PBP binding loops; other site 446462006648 ABC-ATPase subunit interface; other site 446462006649 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462006650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462006651 dimerization interface [polypeptide binding]; other site 446462006652 putative DNA binding site [nucleotide binding]; other site 446462006653 putative Zn2+ binding site [ion binding]; other site 446462006654 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462006655 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446462006656 putative NAD(P) binding site [chemical binding]; other site 446462006657 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462006658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462006659 active site 446462006660 phosphorylation site [posttranslational modification] 446462006661 intermolecular recognition site; other site 446462006662 dimerization interface [polypeptide binding]; other site 446462006663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462006664 DNA binding site [nucleotide binding] 446462006665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462006666 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 446462006667 dimer interface [polypeptide binding]; other site 446462006668 phosphorylation site [posttranslational modification] 446462006669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006670 ATP binding site [chemical binding]; other site 446462006671 G-X-G motif; other site 446462006672 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462006673 anti sigma factor interaction site; other site 446462006674 regulatory phosphorylation site [posttranslational modification]; other site 446462006675 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 446462006676 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446462006677 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446462006678 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462006679 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446462006680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462006681 DNA-binding site [nucleotide binding]; DNA binding site 446462006682 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446462006683 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446462006684 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462006685 anti sigma factor interaction site; other site 446462006686 regulatory phosphorylation site [posttranslational modification]; other site 446462006687 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 446462006688 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 446462006689 metal binding site [ion binding]; metal-binding site 446462006690 dimer interface [polypeptide binding]; other site 446462006691 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462006692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462006693 Mg2+ binding site [ion binding]; other site 446462006694 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446462006695 Integral membrane protein TerC family; Region: TerC; cl10468 446462006696 Isochorismatase family; Region: Isochorismatase; pfam00857 446462006697 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446462006698 catalytic triad [active] 446462006699 conserved cis-peptide bond; other site 446462006700 Helix-turn-helix domain; Region: HTH_31; pfam13560 446462006701 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446462006702 Putative zinc-finger; Region: zf-HC2; pfam13490 446462006703 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 446462006704 conserved repeat domain; Region: B_ant_repeat; TIGR01451 446462006705 Domain of unknown function DUF11; Region: DUF11; pfam01345 446462006706 Domain of unknown function DUF11; Region: DUF11; pfam01345 446462006707 Domain of unknown function DUF11; Region: DUF11; pfam01345 446462006708 Domain of unknown function DUF11; Region: DUF11; pfam01345 446462006709 conserved repeat domain; Region: B_ant_repeat; TIGR01451 446462006710 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 446462006711 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462006712 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446462006713 metal ion-dependent adhesion site (MIDAS); other site 446462006714 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462006715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462006716 active site 446462006717 ATP binding site [chemical binding]; other site 446462006718 substrate binding site [chemical binding]; other site 446462006719 activation loop (A-loop); other site 446462006720 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462006721 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462006722 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462006723 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462006724 acyl-activating enzyme (AAE) consensus motif; other site 446462006725 AMP binding site [chemical binding]; other site 446462006726 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446462006727 phosphate binding site [ion binding]; other site 446462006728 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 446462006729 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462006730 active site 446462006731 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462006732 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462006733 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 446462006734 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462006735 putative NADP binding site [chemical binding]; other site 446462006736 active site 446462006737 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462006738 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462006739 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462006740 active site 446462006741 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462006742 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 446462006743 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446462006744 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462006745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462006746 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446462006747 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462006748 active site 446462006749 TDP-binding site; other site 446462006750 acceptor substrate-binding pocket; other site 446462006751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462006752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462006753 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446462006754 Walker A/P-loop; other site 446462006755 ATP binding site [chemical binding]; other site 446462006756 Q-loop/lid; other site 446462006757 ABC transporter signature motif; other site 446462006758 Walker B; other site 446462006759 D-loop; other site 446462006760 H-loop/switch region; other site 446462006761 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446462006762 active site 446462006763 catalytic triad [active] 446462006764 oxyanion hole [active] 446462006765 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446462006766 amidase catalytic site [active] 446462006767 Zn binding residues [ion binding]; other site 446462006768 substrate binding site [chemical binding]; other site 446462006769 CHRD domain; Region: CHRD; cl06473 446462006770 YCII-related domain; Region: YCII; cl00999 446462006771 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446462006772 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446462006773 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 446462006774 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 446462006775 active site 446462006776 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446462006777 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462006778 NAD(P) binding site [chemical binding]; other site 446462006779 catalytic residues [active] 446462006780 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462006781 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462006782 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 446462006783 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 446462006784 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446462006785 metal ion-dependent adhesion site (MIDAS); other site 446462006786 Cupin; Region: Cupin_6; pfam12852 446462006787 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462006788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462006789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462006790 hydroperoxidase II; Provisional; Region: katE; PRK11249 446462006791 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 446462006792 heme binding pocket [chemical binding]; other site 446462006793 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446462006794 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446462006795 homotrimer interaction site [polypeptide binding]; other site 446462006796 putative active site [active] 446462006797 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 446462006798 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 446462006799 Dehydratase family; Region: ILVD_EDD; cl00340 446462006800 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462006801 NB-ARC domain; Region: NB-ARC; pfam00931 446462006802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462006803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462006804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462006805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462006806 putative substrate translocation pore; other site 446462006807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462006808 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446462006809 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462006810 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462006811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006812 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 446462006813 putative active site [active] 446462006814 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446462006815 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462006816 DNA binding residues [nucleotide binding] 446462006817 drug binding residues [chemical binding]; other site 446462006818 dimer interface [polypeptide binding]; other site 446462006819 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 446462006820 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 446462006821 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462006822 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462006823 active site 446462006824 metal binding site [ion binding]; metal-binding site 446462006825 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446462006826 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462006827 active site 446462006828 ATP binding site [chemical binding]; other site 446462006829 substrate binding site [chemical binding]; other site 446462006830 activation loop (A-loop); other site 446462006831 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446462006832 metal ion-dependent adhesion site (MIDAS); other site 446462006833 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 446462006834 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462006835 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462006836 Cytochrome P450; Region: p450; cl12078 446462006837 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 446462006838 classical (c) SDRs; Region: SDR_c; cd05233 446462006839 NAD(P) binding site [chemical binding]; other site 446462006840 active site 446462006841 sugar efflux transporter B; Provisional; Region: PRK15011 446462006842 MarR family; Region: MarR_2; pfam12802 446462006843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462006844 ATP binding site [chemical binding]; other site 446462006845 putative Mg++ binding site [ion binding]; other site 446462006846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462006847 nucleotide binding region [chemical binding]; other site 446462006848 ATP-binding site [chemical binding]; other site 446462006849 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 446462006850 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462006851 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446462006852 AsnC family; Region: AsnC_trans_reg; pfam01037 446462006853 MgtE intracellular N domain; Region: MgtE_N; cl15244 446462006854 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 446462006855 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446462006856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462006857 putative substrate translocation pore; other site 446462006858 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 446462006859 putative hydrophobic ligand binding site [chemical binding]; other site 446462006860 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446462006861 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462006862 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462006863 active site 446462006864 I-site; other site 446462006865 metal binding site [ion binding]; metal-binding site 446462006866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462006867 Ricin-type beta-trefoil; Region: RICIN; smart00458 446462006868 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462006869 putative sugar binding sites [chemical binding]; other site 446462006870 Q-X-W motif; other site 446462006871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462006872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006873 oxidoreductase; Provisional; Region: PRK06196 446462006874 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446462006875 putative NAD(P) binding site [chemical binding]; other site 446462006876 active site 446462006877 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 446462006878 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 446462006879 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 446462006880 Q-X-W motif; other site 446462006881 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 446462006882 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 446462006883 AAA ATPase domain; Region: AAA_16; pfam13191 446462006884 Pectate lyase; Region: Pectate_lyase; pfam03211 446462006885 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 446462006886 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 446462006887 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446462006888 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446462006889 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462006890 catalytic residue [active] 446462006891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 446462006892 YheO-like PAS domain; Region: PAS_6; pfam08348 446462006893 HTH domain; Region: HTH_22; pfam13309 446462006894 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 446462006895 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462006896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462006897 S-adenosylmethionine binding site [chemical binding]; other site 446462006898 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 446462006899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462006900 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462006901 Pectate lyase; Region: Pectate_lyase; pfam03211 446462006902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462006903 dimer interface [polypeptide binding]; other site 446462006904 conserved gate region; other site 446462006905 putative PBP binding loops; other site 446462006906 ABC-ATPase subunit interface; other site 446462006907 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462006908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462006909 dimer interface [polypeptide binding]; other site 446462006910 conserved gate region; other site 446462006911 putative PBP binding loops; other site 446462006912 ABC-ATPase subunit interface; other site 446462006913 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462006914 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462006915 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446462006916 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446462006917 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 446462006918 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 446462006919 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462006920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462006921 DNA binding site [nucleotide binding] 446462006922 domain linker motif; other site 446462006923 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446462006924 ligand binding site [chemical binding]; other site 446462006925 dimerization interface (open form) [polypeptide binding]; other site 446462006926 dimerization interface (closed form) [polypeptide binding]; other site 446462006927 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446462006928 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462006929 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446462006930 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446462006931 CBD_II domain; Region: CBD_II; smart00637 446462006932 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 446462006933 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 446462006934 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446462006935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006936 (NAP-L) nucleosome assembly protein -L; Provisional; Region: PTZ00007; cl08298 446462006937 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 446462006938 putative ADP-ribose binding site [chemical binding]; other site 446462006939 putative active site [active] 446462006940 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 446462006941 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 446462006942 catalytic residues [active] 446462006943 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446462006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462006945 putative substrate translocation pore; other site 446462006946 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462006947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462006949 DNA-binding site [nucleotide binding]; DNA binding site 446462006950 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446462006951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462006952 DNA binding residues [nucleotide binding] 446462006953 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446462006954 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462006955 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462006956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462006957 NAD(P) binding site [chemical binding]; other site 446462006958 active site 446462006959 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462006960 anti sigma factor interaction site; other site 446462006961 regulatory phosphorylation site [posttranslational modification]; other site 446462006962 ANTAR domain; Region: ANTAR; pfam03861 446462006963 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 446462006964 classical (c) SDRs; Region: SDR_c; cd05233 446462006965 NAD(P) binding site [chemical binding]; other site 446462006966 active site 446462006967 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462006968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006969 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 446462006970 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 446462006971 putative active site [active] 446462006972 metal binding site [ion binding]; metal-binding site 446462006973 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446462006974 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 446462006975 NADP binding site [chemical binding]; other site 446462006976 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462006977 MarR family; Region: MarR_2; pfam12802 446462006978 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462006979 Cytochrome P450; Region: p450; cl12078 446462006980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462006981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462006982 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446462006983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462006984 Walker A/P-loop; other site 446462006985 ATP binding site [chemical binding]; other site 446462006986 Q-loop/lid; other site 446462006987 ABC transporter signature motif; other site 446462006988 Walker B; other site 446462006989 D-loop; other site 446462006990 H-loop/switch region; other site 446462006991 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462006992 TIGR02452 family protein; Region: TIGR02452 446462006993 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 446462006994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462006995 dimerization interface [polypeptide binding]; other site 446462006996 putative DNA binding site [nucleotide binding]; other site 446462006997 putative Zn2+ binding site [ion binding]; other site 446462006998 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462006999 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446462007000 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 446462007001 active site 446462007002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007004 Riboflavin kinase; Region: Flavokinase; pfam01687 446462007005 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446462007006 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446462007007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462007008 Isochorismatase family; Region: Isochorismatase; pfam00857 446462007009 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446462007010 catalytic triad [active] 446462007011 conserved cis-peptide bond; other site 446462007012 pyrimidine utilization protein A; Region: RutA; TIGR03612 446462007013 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446462007014 active site 446462007015 dimer interface [polypeptide binding]; other site 446462007016 non-prolyl cis peptide bond; other site 446462007017 insertion regions; other site 446462007018 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 446462007019 NMT1/THI5 like; Region: NMT1; pfam09084 446462007020 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446462007021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007022 dimer interface [polypeptide binding]; other site 446462007023 conserved gate region; other site 446462007024 putative PBP binding loops; other site 446462007025 ABC-ATPase subunit interface; other site 446462007026 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446462007027 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446462007028 Walker A/P-loop; other site 446462007029 ATP binding site [chemical binding]; other site 446462007030 Q-loop/lid; other site 446462007031 ABC transporter signature motif; other site 446462007032 Walker B; other site 446462007033 D-loop; other site 446462007034 H-loop/switch region; other site 446462007035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462007036 dimerization interface [polypeptide binding]; other site 446462007037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462007038 dimer interface [polypeptide binding]; other site 446462007039 phosphorylation site [posttranslational modification] 446462007040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462007041 Mg2+ binding site [ion binding]; other site 446462007042 G-X-G motif; other site 446462007043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462007044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462007045 active site 446462007046 phosphorylation site [posttranslational modification] 446462007047 intermolecular recognition site; other site 446462007048 dimerization interface [polypeptide binding]; other site 446462007049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462007050 DNA binding site [nucleotide binding] 446462007051 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446462007052 Domain of unknown function DUF21; Region: DUF21; pfam01595 446462007053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446462007054 Transporter associated domain; Region: CorC_HlyC; smart01091 446462007055 Y-family of DNA polymerases; Region: PolY; cl12025 446462007056 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462007057 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462007058 NAD(P) binding site [chemical binding]; other site 446462007059 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 446462007060 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 446462007061 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 446462007062 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 446462007063 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 446462007064 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 446462007065 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446462007066 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446462007067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462007068 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 446462007069 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446462007070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462007071 DNA-binding site [nucleotide binding]; DNA binding site 446462007072 FCD domain; Region: FCD; pfam07729 446462007073 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 446462007074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007075 putative substrate translocation pore; other site 446462007076 dihydroxyacetone kinase; Provisional; Region: PRK14479 446462007077 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446462007078 DAK2 domain; Region: Dak2; pfam02734 446462007079 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 446462007080 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446462007081 substrate binding site [chemical binding]; other site 446462007082 dimer interface [polypeptide binding]; other site 446462007083 catalytic triad [active] 446462007084 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446462007085 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446462007086 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 446462007087 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 446462007088 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 446462007089 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 446462007090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462007091 Walker A/P-loop; other site 446462007092 ATP binding site [chemical binding]; other site 446462007093 Q-loop/lid; other site 446462007094 FAD dependent oxidoreductase; Region: DAO; pfam01266 446462007095 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446462007096 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 446462007097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462007098 Cupin domain; Region: Cupin_2; pfam07883 446462007099 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 446462007100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462007101 active site 446462007102 nucleotide binding site [chemical binding]; other site 446462007103 HIGH motif; other site 446462007104 KMSKS motif; other site 446462007105 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446462007106 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 446462007107 Amidinotransferase; Region: Amidinotransf; cl12043 446462007108 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462007109 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446462007110 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 446462007111 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446462007112 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446462007113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462007115 putative substrate translocation pore; other site 446462007116 Htaa; Region: HtaA; pfam04213 446462007117 O-methyltransferase; Region: Methyltransf_2; pfam00891 446462007118 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462007119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462007120 S-adenosylmethionine binding site [chemical binding]; other site 446462007121 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 446462007122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007123 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007124 DNA binding residues [nucleotide binding] 446462007125 dimerization interface [polypeptide binding]; other site 446462007126 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 446462007127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462007128 Walker A/P-loop; other site 446462007129 ATP binding site [chemical binding]; other site 446462007130 Q-loop/lid; other site 446462007131 ABC transporter signature motif; other site 446462007132 Walker B; other site 446462007133 D-loop; other site 446462007134 H-loop/switch region; other site 446462007135 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 446462007136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007139 putative substrate translocation pore; other site 446462007140 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007141 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007142 active site 446462007143 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007144 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007145 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007146 putative NADP binding site [chemical binding]; other site 446462007147 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007148 active site 446462007149 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007150 Erythronolide synthase docking; Region: Docking; pfam08990 446462007151 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007152 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007153 active site 446462007154 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007155 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462007156 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007157 NADP binding site [chemical binding]; other site 446462007158 active site 446462007159 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007160 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007161 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462007162 active site 446462007163 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462007164 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007165 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462007166 NADP binding site [chemical binding]; other site 446462007167 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007168 active site 446462007169 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007170 Erythronolide synthase docking; Region: Docking; pfam08990 446462007171 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007172 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462007173 active site 446462007174 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462007175 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007176 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462007177 NADP binding site [chemical binding]; other site 446462007178 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007179 active site 446462007180 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007181 Erythronolide synthase docking; Region: Docking; pfam08990 446462007182 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007183 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007184 active site 446462007185 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007186 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007187 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007188 putative NADP binding site [chemical binding]; other site 446462007189 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007190 active site 446462007191 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007192 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007193 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007194 active site 446462007195 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007196 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007197 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007198 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007199 putative NADP binding site [chemical binding]; other site 446462007200 active site 446462007201 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007202 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007203 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007204 active site 446462007205 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007206 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007207 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007208 putative NADP binding site [chemical binding]; other site 446462007209 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007210 active site 446462007211 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007212 Thioesterase; Region: PKS_TE; smart00824 446462007213 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 446462007214 acyl carrier protein; Provisional; Region: PRK07081 446462007215 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462007216 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462007217 acyl-activating enzyme (AAE) consensus motif; other site 446462007218 AMP binding site [chemical binding]; other site 446462007219 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 446462007220 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462007221 acyl-activating enzyme (AAE) consensus motif; other site 446462007222 AMP binding site [chemical binding]; other site 446462007223 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462007224 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462007225 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462007226 aspartate aminotransferase; Provisional; Region: PRK05764 446462007227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462007228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462007229 homodimer interface [polypeptide binding]; other site 446462007230 catalytic residue [active] 446462007231 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 446462007232 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462007233 FeS/SAM binding site; other site 446462007234 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462007235 Cytochrome P450; Region: p450; cl12078 446462007236 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 446462007237 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007238 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007239 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007240 active site 446462007241 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007242 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007243 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007244 putative NADP binding site [chemical binding]; other site 446462007245 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007246 active site 446462007247 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007248 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007249 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007250 active site 446462007251 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007252 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007253 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007254 putative NADP binding site [chemical binding]; other site 446462007255 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007256 active site 446462007257 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007258 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007259 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007260 active site 446462007261 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007262 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007263 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007264 putative NADP binding site [chemical binding]; other site 446462007265 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007266 active site 446462007267 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007268 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462007269 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462007270 active site 446462007271 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462007272 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462007273 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462007274 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462007275 putative NADP binding site [chemical binding]; other site 446462007276 active site 446462007277 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007278 AAA ATPase domain; Region: AAA_16; pfam13191 446462007279 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007281 DNA binding residues [nucleotide binding] 446462007282 dimerization interface [polypeptide binding]; other site 446462007283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462007284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462007285 Walker A/P-loop; other site 446462007286 ATP binding site [chemical binding]; other site 446462007287 Q-loop/lid; other site 446462007288 ABC transporter signature motif; other site 446462007289 Walker B; other site 446462007290 D-loop; other site 446462007291 H-loop/switch region; other site 446462007292 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 446462007293 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446462007294 FtsX-like permease family; Region: FtsX; pfam02687 446462007295 FtsX-like permease family; Region: FtsX; pfam02687 446462007296 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462007298 active site 446462007299 phosphorylation site [posttranslational modification] 446462007300 intermolecular recognition site; other site 446462007301 dimerization interface [polypeptide binding]; other site 446462007302 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007303 DNA binding residues [nucleotide binding] 446462007304 dimerization interface [polypeptide binding]; other site 446462007305 Putative sensor; Region: Sensor; pfam13796 446462007306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462007307 Histidine kinase; Region: HisKA_3; pfam07730 446462007308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462007309 ATP binding site [chemical binding]; other site 446462007310 Mg2+ binding site [ion binding]; other site 446462007311 G-X-G motif; other site 446462007312 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462007313 active site 446462007314 catalytic triad [active] 446462007315 oxyanion hole [active] 446462007316 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 446462007317 active site 446462007318 Cna protein B-type domain; Region: Cna_B; pfam05738 446462007319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462007320 S-adenosylmethionine binding site [chemical binding]; other site 446462007321 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446462007322 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 446462007323 putative ligand binding residues [chemical binding]; other site 446462007324 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462007325 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462007326 ABC-ATPase subunit interface; other site 446462007327 dimer interface [polypeptide binding]; other site 446462007328 putative PBP binding regions; other site 446462007329 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462007330 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462007331 Walker A/P-loop; other site 446462007332 ATP binding site [chemical binding]; other site 446462007333 Q-loop/lid; other site 446462007334 ABC transporter signature motif; other site 446462007335 Walker B; other site 446462007336 D-loop; other site 446462007337 H-loop/switch region; other site 446462007338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007339 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446462007340 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 446462007341 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462007342 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462007343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007344 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 446462007345 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462007346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462007347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007349 DNA binding residues [nucleotide binding] 446462007350 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 446462007351 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446462007352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007353 putative substrate translocation pore; other site 446462007354 Condensation domain; Region: Condensation; pfam00668 446462007355 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462007356 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462007357 acyl-activating enzyme (AAE) consensus motif; other site 446462007358 AMP binding site [chemical binding]; other site 446462007359 Condensation domain; Region: Condensation; pfam00668 446462007360 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 446462007361 Condensation domain; Region: Condensation; pfam00668 446462007362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462007363 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462007364 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462007365 acyl-activating enzyme (AAE) consensus motif; other site 446462007366 AMP binding site [chemical binding]; other site 446462007367 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462007368 Condensation domain; Region: Condensation; pfam00668 446462007369 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 446462007370 Condensation domain; Region: Condensation; pfam00668 446462007371 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462007372 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462007373 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462007374 Walker A/P-loop; other site 446462007375 ATP binding site [chemical binding]; other site 446462007376 Q-loop/lid; other site 446462007377 ABC transporter signature motif; other site 446462007378 Walker B; other site 446462007379 D-loop; other site 446462007380 H-loop/switch region; other site 446462007381 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446462007382 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462007383 ABC-ATPase subunit interface; other site 446462007384 dimer interface [polypeptide binding]; other site 446462007385 putative PBP binding regions; other site 446462007386 FecCD transport family; Region: FecCD; pfam01032 446462007387 ABC-ATPase subunit interface; other site 446462007388 dimer interface [polypeptide binding]; other site 446462007389 putative PBP binding regions; other site 446462007390 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462007391 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446462007392 intersubunit interface [polypeptide binding]; other site 446462007393 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446462007394 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446462007395 FAD binding pocket [chemical binding]; other site 446462007396 FAD binding motif [chemical binding]; other site 446462007397 phosphate binding motif [ion binding]; other site 446462007398 NAD binding pocket [chemical binding]; other site 446462007399 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 446462007400 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 446462007401 acyl-activating enzyme (AAE) consensus motif; other site 446462007402 active site 446462007403 AMP binding site [chemical binding]; other site 446462007404 substrate binding site [chemical binding]; other site 446462007405 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446462007406 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 446462007407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462007408 NAD(P) binding site [chemical binding]; other site 446462007409 active site 446462007410 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462007411 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462007412 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462007413 ABC-ATPase subunit interface; other site 446462007414 dimer interface [polypeptide binding]; other site 446462007415 putative PBP binding regions; other site 446462007416 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462007417 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462007418 Walker A/P-loop; other site 446462007419 ATP binding site [chemical binding]; other site 446462007420 Q-loop/lid; other site 446462007421 ABC transporter signature motif; other site 446462007422 Walker B; other site 446462007423 D-loop; other site 446462007424 H-loop/switch region; other site 446462007425 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 446462007426 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446462007427 putative ligand binding residues [chemical binding]; other site 446462007428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462007429 non-specific DNA binding site [nucleotide binding]; other site 446462007430 salt bridge; other site 446462007431 sequence-specific DNA binding site [nucleotide binding]; other site 446462007432 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 446462007433 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462007434 Histidine kinase; Region: HisKA_3; pfam07730 446462007435 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462007436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462007438 active site 446462007439 phosphorylation site [posttranslational modification] 446462007440 intermolecular recognition site; other site 446462007441 dimerization interface [polypeptide binding]; other site 446462007442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007443 DNA binding residues [nucleotide binding] 446462007444 dimerization interface [polypeptide binding]; other site 446462007445 enolase; Provisional; Region: eno; PRK00077 446462007446 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446462007447 dimer interface [polypeptide binding]; other site 446462007448 metal binding site [ion binding]; metal-binding site 446462007449 substrate binding pocket [chemical binding]; other site 446462007450 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 446462007451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462007452 Walker A/P-loop; other site 446462007453 ATP binding site [chemical binding]; other site 446462007454 Q-loop/lid; other site 446462007455 ABC transporter signature motif; other site 446462007456 Walker B; other site 446462007457 D-loop; other site 446462007458 H-loop/switch region; other site 446462007459 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446462007460 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 446462007461 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446462007462 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462007463 GAF domain; Region: GAF_2; pfam13185 446462007464 GAF domain; Region: GAF_2; pfam13185 446462007465 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462007466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462007467 dimer interface [polypeptide binding]; other site 446462007468 putative CheW interface [polypeptide binding]; other site 446462007469 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462007470 GAF domain; Region: GAF; pfam01590 446462007471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 446462007472 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 446462007473 PA14 domain; Region: PA14; cl08459 446462007474 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462007475 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446462007476 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446462007477 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446462007478 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446462007479 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446462007480 putative active site [active] 446462007481 benzoate transport; Region: 2A0115; TIGR00895 446462007482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007483 putative substrate translocation pore; other site 446462007484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007485 GAF domain; Region: GAF; cl17456 446462007486 GAF domain; Region: GAF_2; pfam13185 446462007487 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446462007488 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462007489 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 446462007490 active site 446462007491 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462007493 active site 446462007494 phosphorylation site [posttranslational modification] 446462007495 intermolecular recognition site; other site 446462007496 dimerization interface [polypeptide binding]; other site 446462007497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007498 DNA binding residues [nucleotide binding] 446462007499 dimerization interface [polypeptide binding]; other site 446462007500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462007501 Histidine kinase; Region: HisKA_3; pfam07730 446462007502 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462007503 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462007504 Walker A/P-loop; other site 446462007505 ATP binding site [chemical binding]; other site 446462007506 Q-loop/lid; other site 446462007507 ABC transporter signature motif; other site 446462007508 Walker B; other site 446462007509 D-loop; other site 446462007510 H-loop/switch region; other site 446462007511 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446462007512 TPR repeat; Region: TPR_11; pfam13414 446462007513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462007514 binding surface 446462007515 TPR motif; other site 446462007516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462007517 TPR motif; other site 446462007518 binding surface 446462007519 TPR repeat; Region: TPR_11; pfam13414 446462007520 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462007521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446462007522 nucleotide binding site [chemical binding]; other site 446462007523 AAA ATPase domain; Region: AAA_16; pfam13191 446462007524 NACHT domain; Region: NACHT; pfam05729 446462007525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462007526 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446462007527 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446462007528 metal-binding site [ion binding] 446462007529 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446462007530 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446462007531 Thioredoxin; Region: Thioredoxin_4; cl17273 446462007532 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 446462007533 putative active site [active] 446462007534 redox center [active] 446462007535 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446462007536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462007537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462007538 DNA binding residues [nucleotide binding] 446462007539 Putative zinc-finger; Region: zf-HC2; pfam13490 446462007540 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446462007541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462007542 Coenzyme A binding pocket [chemical binding]; other site 446462007543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007545 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462007546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462007547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462007548 Walker A/P-loop; other site 446462007549 ATP binding site [chemical binding]; other site 446462007550 Q-loop/lid; other site 446462007551 ABC transporter signature motif; other site 446462007552 Walker B; other site 446462007553 D-loop; other site 446462007554 H-loop/switch region; other site 446462007555 5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555 446462007556 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 446462007557 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462007558 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446462007559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007560 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446462007561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007562 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462007563 Cellulose binding domain; Region: CBM_2; pfam00553 446462007564 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 446462007565 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462007566 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 446462007567 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462007568 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462007569 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446462007570 putative dimerization interface [polypeptide binding]; other site 446462007571 threonine dehydratase; Provisional; Region: PRK08246 446462007572 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 446462007573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462007574 catalytic residue [active] 446462007575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462007576 salt bridge; other site 446462007577 non-specific DNA binding site [nucleotide binding]; other site 446462007578 sequence-specific DNA binding site [nucleotide binding]; other site 446462007579 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462007580 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446462007581 NAD(P) binding site [chemical binding]; other site 446462007582 catalytic residues [active] 446462007583 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462007584 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462007585 DNA binding residues [nucleotide binding] 446462007586 MMPL family; Region: MMPL; pfam03176 446462007587 MMPL family; Region: MMPL; pfam03176 446462007588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007590 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462007591 GAF domain; Region: GAF_3; pfam13492 446462007592 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446462007593 Asp23 family; Region: Asp23; pfam03780 446462007594 Asp23 family; Region: Asp23; pfam03780 446462007595 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462007596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462007597 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462007598 GAF domain; Region: GAF_3; pfam13492 446462007599 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446462007600 GAF domain; Region: GAF; pfam01590 446462007601 GAF domain; Region: GAF_2; pfam13185 446462007602 ANTAR domain; Region: ANTAR; cl04297 446462007603 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462007604 anti sigma factor interaction site; other site 446462007605 regulatory phosphorylation site [posttranslational modification]; other site 446462007606 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462007608 active site 446462007609 phosphorylation site [posttranslational modification] 446462007610 intermolecular recognition site; other site 446462007611 dimerization interface [polypeptide binding]; other site 446462007612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007613 DNA binding residues [nucleotide binding] 446462007614 dimerization interface [polypeptide binding]; other site 446462007615 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 446462007616 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446462007617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462007618 S-adenosylmethionine binding site [chemical binding]; other site 446462007619 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462007620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462007621 NAD(P) binding site [chemical binding]; other site 446462007622 active site 446462007623 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 446462007624 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462007625 FeS/SAM binding site; other site 446462007626 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446462007627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462007628 Coenzyme A binding pocket [chemical binding]; other site 446462007629 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462007630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462007631 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446462007632 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446462007633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462007634 NAD(P) binding site [chemical binding]; other site 446462007635 active site 446462007636 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462007637 catalytic core [active] 446462007638 Uncharacterized conserved protein [Function unknown]; Region: COG3379 446462007639 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446462007640 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462007641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462007642 Walker A/P-loop; other site 446462007643 ATP binding site [chemical binding]; other site 446462007644 Q-loop/lid; other site 446462007645 ABC transporter signature motif; other site 446462007646 Walker B; other site 446462007647 D-loop; other site 446462007648 H-loop/switch region; other site 446462007649 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462007650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462007651 NAD(P) binding site [chemical binding]; other site 446462007652 active site 446462007653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007654 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007655 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462007656 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462007657 DNA binding site [nucleotide binding] 446462007658 domain linker motif; other site 446462007659 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462007660 dimerization interface [polypeptide binding]; other site 446462007661 ligand binding site [chemical binding]; other site 446462007662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446462007663 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 446462007664 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462007665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446462007666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007667 ABC-ATPase subunit interface; other site 446462007668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462007669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007670 dimer interface [polypeptide binding]; other site 446462007671 conserved gate region; other site 446462007672 putative PBP binding loops; other site 446462007673 ABC-ATPase subunit interface; other site 446462007674 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 446462007675 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 446462007676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446462007677 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 446462007678 substrate binding site [chemical binding]; other site 446462007679 active site 446462007680 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446462007681 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462007682 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462007683 EthD domain; Region: EthD; pfam07110 446462007684 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446462007685 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462007686 DNA binding residues [nucleotide binding] 446462007687 putative dimer interface [polypeptide binding]; other site 446462007688 transcriptional regulator NarP; Provisional; Region: PRK10403 446462007689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007690 DNA binding residues [nucleotide binding] 446462007691 dimerization interface [polypeptide binding]; other site 446462007692 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446462007693 homotrimer interaction site [polypeptide binding]; other site 446462007694 putative active site [active] 446462007695 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446462007696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462007697 DNA-binding site [nucleotide binding]; DNA binding site 446462007698 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446462007699 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 446462007700 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446462007701 PYR/PP interface [polypeptide binding]; other site 446462007702 dimer interface [polypeptide binding]; other site 446462007703 TPP binding site [chemical binding]; other site 446462007704 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446462007705 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 446462007706 TPP-binding site [chemical binding]; other site 446462007707 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446462007708 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 446462007709 metal binding site [ion binding]; metal-binding site 446462007710 dimer interface [polypeptide binding]; other site 446462007711 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 446462007712 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462007713 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 446462007714 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 446462007715 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 446462007716 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 446462007717 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446462007718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007719 dimer interface [polypeptide binding]; other site 446462007720 conserved gate region; other site 446462007721 putative PBP binding loops; other site 446462007722 ABC-ATPase subunit interface; other site 446462007723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007724 dimer interface [polypeptide binding]; other site 446462007725 conserved gate region; other site 446462007726 putative PBP binding loops; other site 446462007727 ABC-ATPase subunit interface; other site 446462007728 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446462007729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462007730 Walker A/P-loop; other site 446462007731 ATP binding site [chemical binding]; other site 446462007732 Q-loop/lid; other site 446462007733 ABC transporter signature motif; other site 446462007734 Walker B; other site 446462007735 D-loop; other site 446462007736 H-loop/switch region; other site 446462007737 TOBE domain; Region: TOBE_2; pfam08402 446462007738 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462007739 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 446462007740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462007741 NAD(P) binding site [chemical binding]; other site 446462007742 active site 446462007743 HTH domain; Region: HTH_11; pfam08279 446462007744 WYL domain; Region: WYL; pfam13280 446462007745 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462007746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007748 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446462007749 active site 446462007750 metal binding site [ion binding]; metal-binding site 446462007751 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 446462007752 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446462007753 ligand binding site [chemical binding]; other site 446462007754 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446462007755 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446462007756 RHS Repeat; Region: RHS_repeat; pfam05593 446462007757 RHS Repeat; Region: RHS_repeat; pfam05593 446462007758 RHS Repeat; Region: RHS_repeat; cl11982 446462007759 RHS Repeat; Region: RHS_repeat; pfam05593 446462007760 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 446462007761 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446462007762 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 446462007763 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 446462007764 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 446462007765 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462007766 intersubunit interface [polypeptide binding]; other site 446462007767 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446462007768 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462007769 ABC-ATPase subunit interface; other site 446462007770 dimer interface [polypeptide binding]; other site 446462007771 putative PBP binding regions; other site 446462007772 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 446462007773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462007774 Walker A/P-loop; other site 446462007775 ATP binding site [chemical binding]; other site 446462007776 Q-loop/lid; other site 446462007777 ABC transporter signature motif; other site 446462007778 Walker B; other site 446462007779 D-loop; other site 446462007780 Htaa; Region: HtaA; pfam04213 446462007781 hypothetical protein; Provisional; Region: PRK07236 446462007782 FAD binding domain; Region: FAD_binding_3; pfam01494 446462007783 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462007784 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446462007785 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 446462007786 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 446462007787 active site 446462007788 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446462007789 helix-hairpin-helix signature motif; other site 446462007790 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446462007791 active site 446462007792 catalytic triad [active] 446462007793 oxyanion hole [active] 446462007794 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 446462007795 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446462007796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007800 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446462007801 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 446462007802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446462007803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462007804 Cytochrome P450; Region: p450; cl12078 446462007805 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462007806 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462007807 Cytochrome P450; Region: p450; cl12078 446462007808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462007809 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462007810 TDP-binding site; other site 446462007811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462007812 HAMP domain; Region: HAMP; pfam00672 446462007813 dimerization interface [polypeptide binding]; other site 446462007814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462007815 dimer interface [polypeptide binding]; other site 446462007816 phosphorylation site [posttranslational modification] 446462007817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446462007818 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446462007819 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462007820 DNA binding residues [nucleotide binding] 446462007821 drug binding residues [chemical binding]; other site 446462007822 dimer interface [polypeptide binding]; other site 446462007823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462007824 hypothetical protein; Provisional; Region: PRK08204 446462007825 active site 446462007826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007828 WHG domain; Region: WHG; pfam13305 446462007829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462007830 AMP-binding enzyme; Region: AMP-binding; pfam00501 446462007831 acyl-activating enzyme (AAE) consensus motif; other site 446462007832 active site 446462007833 AMP binding site [chemical binding]; other site 446462007834 CoA binding site [chemical binding]; other site 446462007835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462007836 CoA binding site [chemical binding]; other site 446462007837 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446462007838 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462007839 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462007840 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 446462007841 GAF domain; Region: GAF; pfam01590 446462007842 Phytochrome region; Region: PHY; pfam00360 446462007843 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462007844 dimer interface [polypeptide binding]; other site 446462007845 phosphorylation site [posttranslational modification] 446462007846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462007847 ATP binding site [chemical binding]; other site 446462007848 Mg2+ binding site [ion binding]; other site 446462007849 G-X-G motif; other site 446462007850 GAF domain; Region: GAF; cl17456 446462007851 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462007852 Response regulator receiver domain; Region: Response_reg; pfam00072 446462007853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462007854 active site 446462007855 phosphorylation site [posttranslational modification] 446462007856 intermolecular recognition site; other site 446462007857 dimerization interface [polypeptide binding]; other site 446462007858 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462007859 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462007860 putative Zn2+ binding site [ion binding]; other site 446462007861 putative DNA binding site [nucleotide binding]; other site 446462007862 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446462007863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462007864 NAD(P) binding site [chemical binding]; other site 446462007865 active site 446462007866 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462007867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007868 dimer interface [polypeptide binding]; other site 446462007869 conserved gate region; other site 446462007870 putative PBP binding loops; other site 446462007871 ABC-ATPase subunit interface; other site 446462007872 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446462007873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007874 putative PBP binding loops; other site 446462007875 ABC-ATPase subunit interface; other site 446462007876 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462007877 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462007878 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 446462007879 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 446462007880 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446462007881 putative ligand binding site [chemical binding]; other site 446462007882 putative NAD binding site [chemical binding]; other site 446462007883 catalytic site [active] 446462007884 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462007885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462007886 DNA-binding site [nucleotide binding]; DNA binding site 446462007887 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462007888 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462007889 ligand binding site [chemical binding]; other site 446462007890 dimerization interface [polypeptide binding]; other site 446462007891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 446462007892 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462007893 AAA ATPase domain; Region: AAA_16; pfam13191 446462007894 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446462007895 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 446462007896 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007898 DNA binding residues [nucleotide binding] 446462007899 dimerization interface [polypeptide binding]; other site 446462007900 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 446462007901 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 446462007902 CARDB; Region: CARDB; pfam07705 446462007903 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 446462007904 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 446462007905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462007906 ATP binding site [chemical binding]; other site 446462007907 Walker A motif; other site 446462007908 Walker B motif; other site 446462007909 arginine finger; other site 446462007910 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 446462007911 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446462007912 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462007913 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462007914 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462007915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462007916 binding surface 446462007917 TPR motif; other site 446462007918 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462007919 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 446462007920 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 446462007921 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 446462007922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446462007923 Phage protein D [General function prediction only]; Region: COG3500 446462007924 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 446462007925 PAAR motif; Region: PAAR_motif; pfam05488 446462007926 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 446462007927 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 446462007928 phage tail protein domain; Region: tail_TIGR02242 446462007929 Double zinc ribbon; Region: DZR; pfam12773 446462007930 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 446462007931 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462007932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462007933 NAD(P) binding site [chemical binding]; other site 446462007934 active site 446462007935 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462007936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462007937 DNA binding residues [nucleotide binding] 446462007938 dimerization interface [polypeptide binding]; other site 446462007939 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446462007940 DNA binding site [nucleotide binding] 446462007941 AAA ATPase domain; Region: AAA_16; pfam13191 446462007942 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446462007943 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462007944 AAA ATPase domain; Region: AAA_16; pfam13191 446462007945 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446462007946 Ligand Binding Site [chemical binding]; other site 446462007947 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446462007948 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446462007949 phosphate binding site [ion binding]; other site 446462007950 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 446462007951 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 446462007952 nucleotide binding pocket [chemical binding]; other site 446462007953 K-X-D-G motif; other site 446462007954 catalytic site [active] 446462007955 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446462007956 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446462007957 Dimer interface [polypeptide binding]; other site 446462007958 BRCT sequence motif; other site 446462007959 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462007960 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 446462007961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462007962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462007963 homodimer interface [polypeptide binding]; other site 446462007964 catalytic residue [active] 446462007965 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462007966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462007967 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462007968 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462007969 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462007970 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446462007971 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462007972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462007973 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462007974 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462007975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007976 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446462007977 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 446462007978 nudix motif; other site 446462007979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462007980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462007981 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462007982 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446462007983 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446462007984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462007985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462007986 putative substrate translocation pore; other site 446462007987 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462007988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462007989 salt bridge; other site 446462007990 non-specific DNA binding site [nucleotide binding]; other site 446462007991 sequence-specific DNA binding site [nucleotide binding]; other site 446462007992 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 446462007993 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462007994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462007995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462007996 dimer interface [polypeptide binding]; other site 446462007997 conserved gate region; other site 446462007998 putative PBP binding loops; other site 446462007999 ABC-ATPase subunit interface; other site 446462008000 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462008001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462008002 dimer interface [polypeptide binding]; other site 446462008003 conserved gate region; other site 446462008004 putative PBP binding loops; other site 446462008005 ABC-ATPase subunit interface; other site 446462008006 putative alpha-glucosidase; Provisional; Region: PRK10658 446462008007 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 446462008008 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 446462008009 active site 446462008010 homotrimer interface [polypeptide binding]; other site 446462008011 catalytic site [active] 446462008012 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 446462008013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462008014 putative DNA binding site [nucleotide binding]; other site 446462008015 putative Zn2+ binding site [ion binding]; other site 446462008016 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462008017 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462008018 DNA binding site [nucleotide binding] 446462008019 domain linker motif; other site 446462008020 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462008021 ligand binding site [chemical binding]; other site 446462008022 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cl17565 446462008023 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462008024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462008025 sequence-specific DNA binding site [nucleotide binding]; other site 446462008026 salt bridge; other site 446462008027 Cupin domain; Region: Cupin_2; pfam07883 446462008028 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446462008029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008030 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446462008031 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462008032 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446462008033 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 446462008034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462008035 non-specific DNA binding site [nucleotide binding]; other site 446462008036 salt bridge; other site 446462008037 sequence-specific DNA binding site [nucleotide binding]; other site 446462008038 Cupin domain; Region: Cupin_2; cl17218 446462008039 short chain dehydrogenase; Provisional; Region: PRK06940 446462008040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008041 active site 446462008042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008044 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446462008045 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 446462008046 active site 446462008047 substrate binding site [chemical binding]; other site 446462008048 catalytic site [active] 446462008049 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446462008050 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462008051 DNA binding residues [nucleotide binding] 446462008052 dimer interface [polypeptide binding]; other site 446462008053 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462008054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462008055 active site 446462008056 phosphorylation site [posttranslational modification] 446462008057 intermolecular recognition site; other site 446462008058 dimerization interface [polypeptide binding]; other site 446462008059 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462008060 DNA binding residues [nucleotide binding] 446462008061 dimerization interface [polypeptide binding]; other site 446462008062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462008063 Histidine kinase; Region: HisKA_3; pfam07730 446462008064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462008065 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462008066 Walker A/P-loop; other site 446462008067 ATP binding site [chemical binding]; other site 446462008068 Q-loop/lid; other site 446462008069 ABC transporter signature motif; other site 446462008070 Walker B; other site 446462008071 D-loop; other site 446462008072 H-loop/switch region; other site 446462008073 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446462008074 FtsX-like permease family; Region: FtsX; pfam02687 446462008075 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446462008076 FtsX-like permease family; Region: FtsX; pfam02687 446462008077 Uncharacterized conserved protein [Function unknown]; Region: COG3379 446462008078 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446462008079 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 446462008080 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446462008081 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 446462008082 Ca binding site [ion binding]; other site 446462008083 active site 446462008084 catalytic site [active] 446462008085 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446462008086 SnoaL-like domain; Region: SnoaL_2; pfam12680 446462008087 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446462008088 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 446462008089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008091 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446462008092 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 446462008093 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 446462008094 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446462008095 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446462008096 FAD binding pocket [chemical binding]; other site 446462008097 FAD binding motif [chemical binding]; other site 446462008098 phosphate binding motif [ion binding]; other site 446462008099 NAD binding pocket [chemical binding]; other site 446462008100 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 446462008101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008103 Predicted flavoprotein [General function prediction only]; Region: COG0431 446462008104 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446462008105 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 446462008106 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462008107 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446462008108 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 446462008109 active site 446462008110 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462008111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462008112 Walker A/P-loop; other site 446462008113 ATP binding site [chemical binding]; other site 446462008114 Q-loop/lid; other site 446462008115 ABC transporter signature motif; other site 446462008116 Walker B; other site 446462008117 D-loop; other site 446462008118 H-loop/switch region; other site 446462008119 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462008120 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446462008121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462008122 Walker A/P-loop; other site 446462008123 ATP binding site [chemical binding]; other site 446462008124 Q-loop/lid; other site 446462008125 ABC transporter signature motif; other site 446462008126 Walker B; other site 446462008127 D-loop; other site 446462008128 H-loop/switch region; other site 446462008129 hypothetical protein; Provisional; Region: PRK06215 446462008130 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 446462008131 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446462008132 Subtilisin inhibitor-like; Region: SSI; cl11594 446462008133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462008134 RNA ligase; Region: RNA_ligase; pfam09414 446462008135 AAA domain; Region: AAA_33; pfam13671 446462008136 Protein of unknown function (DUF504); Region: DUF504; cl00661 446462008137 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 446462008138 putative catalytic site [active] 446462008139 putative metal binding site [ion binding]; other site 446462008140 putative phosphate binding site [ion binding]; other site 446462008141 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 446462008142 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 446462008143 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 446462008144 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446462008145 DinB superfamily; Region: DinB_2; pfam12867 446462008146 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 446462008147 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 446462008148 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 446462008149 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 446462008150 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446462008151 Cysteine-rich domain; Region: CCG; pfam02754 446462008152 Cysteine-rich domain; Region: CCG; pfam02754 446462008153 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446462008154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462008155 DNA-binding site [nucleotide binding]; DNA binding site 446462008156 FCD domain; Region: FCD; cl11656 446462008157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462008158 DNA binding site [nucleotide binding] 446462008159 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462008160 domain linker motif; other site 446462008161 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462008162 ligand binding site [chemical binding]; other site 446462008163 dimerization interface [polypeptide binding]; other site 446462008164 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446462008165 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446462008166 Walker A/P-loop; other site 446462008167 ATP binding site [chemical binding]; other site 446462008168 Q-loop/lid; other site 446462008169 ABC transporter signature motif; other site 446462008170 Walker B; other site 446462008171 D-loop; other site 446462008172 H-loop/switch region; other site 446462008173 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446462008174 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462008175 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462008176 TM-ABC transporter signature motif; other site 446462008177 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462008178 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462008179 TM-ABC transporter signature motif; other site 446462008180 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 446462008181 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 446462008182 ligand binding site [chemical binding]; other site 446462008183 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 446462008184 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 446462008185 short chain dehydrogenase; Validated; Region: PRK08324 446462008186 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 446462008187 active site 446462008188 Zn2+ binding site [ion binding]; other site 446462008189 intersubunit interface [polypeptide binding]; other site 446462008190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008191 NAD(P) binding site [chemical binding]; other site 446462008192 active site 446462008193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462008194 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 446462008195 nucleotide binding site [chemical binding]; other site 446462008196 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446462008197 active site 446462008198 metal binding site [ion binding]; metal-binding site 446462008199 hypothetical protein; Provisional; Region: PRK08204 446462008200 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462008201 active site 446462008202 SnoaL-like domain; Region: SnoaL_2; pfam12680 446462008203 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 446462008204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462008205 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462008206 dimerization interface [polypeptide binding]; other site 446462008207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462008208 Histidine kinase; Region: HisKA_3; pfam07730 446462008209 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462008210 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 446462008211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462008212 Right handed beta helix region; Region: Beta_helix; pfam13229 446462008213 Domain of unknown function (DUF202); Region: DUF202; cl09954 446462008214 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462008215 Cytochrome P450; Region: p450; cl12078 446462008216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462008217 putative DNA binding site [nucleotide binding]; other site 446462008218 putative Zn2+ binding site [ion binding]; other site 446462008219 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 446462008220 heme binding pocket [chemical binding]; other site 446462008221 heme ligand [chemical binding]; other site 446462008222 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446462008223 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446462008224 active site 446462008225 catalytic triad [active] 446462008226 oxyanion hole [active] 446462008227 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 446462008228 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462008229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462008230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462008231 dimer interface [polypeptide binding]; other site 446462008232 conserved gate region; other site 446462008233 putative PBP binding loops; other site 446462008234 ABC-ATPase subunit interface; other site 446462008235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462008236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462008237 putative PBP binding loops; other site 446462008238 ABC-ATPase subunit interface; other site 446462008239 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446462008240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462008241 Walker A/P-loop; other site 446462008242 ATP binding site [chemical binding]; other site 446462008243 Q-loop/lid; other site 446462008244 ABC transporter signature motif; other site 446462008245 Walker B; other site 446462008246 D-loop; other site 446462008247 H-loop/switch region; other site 446462008248 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 446462008249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462008250 Walker A/P-loop; other site 446462008251 ATP binding site [chemical binding]; other site 446462008252 Q-loop/lid; other site 446462008253 ABC transporter signature motif; other site 446462008254 Walker B; other site 446462008255 D-loop; other site 446462008256 H-loop/switch region; other site 446462008257 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 446462008258 active site 446462008259 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 446462008260 dimer interface [polypeptide binding]; other site 446462008261 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446462008262 Ligand Binding Site [chemical binding]; other site 446462008263 Molecular Tunnel; other site 446462008264 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446462008265 hypothetical protein; Provisional; Region: PRK07483 446462008266 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462008267 inhibitor-cofactor binding pocket; inhibition site 446462008268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462008269 catalytic residue [active] 446462008270 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 446462008271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462008272 inhibitor-cofactor binding pocket; inhibition site 446462008273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462008274 catalytic residue [active] 446462008275 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462008276 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 446462008277 NAD(P) binding site [chemical binding]; other site 446462008278 catalytic residues [active] 446462008279 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 446462008280 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 446462008281 THF binding site; other site 446462008282 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446462008283 substrate binding site [chemical binding]; other site 446462008284 THF binding site; other site 446462008285 zinc-binding site [ion binding]; other site 446462008286 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 446462008287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008288 S-adenosylmethionine binding site [chemical binding]; other site 446462008289 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462008290 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462008291 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 446462008292 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446462008293 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 446462008294 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 446462008295 homotrimer interaction site [polypeptide binding]; other site 446462008296 putative active site [active] 446462008297 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462008298 MarR family; Region: MarR; pfam01047 446462008299 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 446462008300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462008301 dimerization interface [polypeptide binding]; other site 446462008302 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462008303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462008304 dimer interface [polypeptide binding]; other site 446462008305 putative CheW interface [polypeptide binding]; other site 446462008306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462008307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462008308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446462008309 dimerization interface [polypeptide binding]; other site 446462008310 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 446462008311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462008312 dimerization interface [polypeptide binding]; other site 446462008313 putative DNA binding site [nucleotide binding]; other site 446462008314 putative Zn2+ binding site [ion binding]; other site 446462008315 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 446462008316 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446462008317 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446462008318 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 446462008319 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 446462008320 motif II; other site 446462008321 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462008322 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462008323 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 446462008324 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 446462008325 Adenosylhomocysteinase; Provisional; Region: PTZ00075 446462008326 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 446462008327 homotetramer interface [polypeptide binding]; other site 446462008328 ligand binding site [chemical binding]; other site 446462008329 catalytic site [active] 446462008330 NAD binding site [chemical binding]; other site 446462008331 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446462008332 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446462008333 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446462008334 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446462008335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 446462008336 alpha-galactosidase; Region: PLN02808; cl17638 446462008337 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462008338 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462008339 putative sugar binding sites [chemical binding]; other site 446462008340 Q-X-W motif; other site 446462008341 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 446462008342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446462008343 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462008344 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462008345 putative sugar binding sites [chemical binding]; other site 446462008346 Q-X-W motif; other site 446462008347 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 446462008348 active site 446462008349 catalytic triad [active] 446462008350 oxyanion hole [active] 446462008351 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462008352 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462008353 putative sugar binding sites [chemical binding]; other site 446462008354 Q-X-W motif; other site 446462008355 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446462008356 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462008357 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 446462008358 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462008359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462008360 catalytic residue [active] 446462008361 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462008362 AsnC family; Region: AsnC_trans_reg; pfam01037 446462008363 TIR domain; Region: TIR_2; cl17458 446462008364 Protein of unknown function (DUF3732); Region: DUF3732; pfam12532 446462008365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008368 NmrA-like family; Region: NmrA; pfam05368 446462008369 NAD(P) binding site [chemical binding]; other site 446462008370 active site 446462008371 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462008372 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 446462008373 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462008374 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 446462008375 FAD binding domain; Region: FAD_binding_4; pfam01565 446462008376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462008377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462008378 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446462008379 dimerization interface [polypeptide binding]; other site 446462008380 substrate binding pocket [chemical binding]; other site 446462008381 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446462008382 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 446462008383 FAD binding pocket [chemical binding]; other site 446462008384 conserved FAD binding motif [chemical binding]; other site 446462008385 phosphate binding motif [ion binding]; other site 446462008386 beta-alpha-beta structure motif; other site 446462008387 NAD binding pocket [chemical binding]; other site 446462008388 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446462008389 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446462008390 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446462008391 dimer interface [polypeptide binding]; other site 446462008392 active site 446462008393 CoA binding pocket [chemical binding]; other site 446462008394 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462008395 Cytochrome P450; Region: p450; cl12078 446462008396 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462008397 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 446462008398 active site 446462008399 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 446462008400 ABC1 family; Region: ABC1; cl17513 446462008401 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 446462008402 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462008403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462008404 catalytic residue [active] 446462008405 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446462008406 Protein of unknown function (DUF419); Region: DUF419; cl15265 446462008407 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462008408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008409 S-adenosylmethionine binding site [chemical binding]; other site 446462008410 short chain dehydrogenase; Provisional; Region: PRK12937 446462008411 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 446462008412 NADP binding site [chemical binding]; other site 446462008413 homodimer interface [polypeptide binding]; other site 446462008414 active site 446462008415 substrate binding site [chemical binding]; other site 446462008416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008418 WHG domain; Region: WHG; pfam13305 446462008419 Class I aldolases; Region: Aldolase_Class_I; cl17187 446462008420 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 446462008421 catalytic residue [active] 446462008422 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446462008423 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 446462008424 NAD binding site [chemical binding]; other site 446462008425 substrate binding site [chemical binding]; other site 446462008426 catalytic Zn binding site [ion binding]; other site 446462008427 structural Zn binding site [ion binding]; other site 446462008428 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462008429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008430 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446462008431 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446462008432 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446462008433 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446462008434 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446462008435 B3/4 domain; Region: B3_4; pfam03483 446462008436 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462008437 Cytochrome P450; Region: p450; cl12078 446462008438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008440 WHG domain; Region: WHG; pfam13305 446462008441 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446462008442 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 446462008443 conserved cys residue [active] 446462008444 CAAX protease self-immunity; Region: Abi; pfam02517 446462008445 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 446462008446 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446462008447 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462008448 putative active site [active] 446462008449 putative metal binding site [ion binding]; other site 446462008450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008452 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462008453 Ricin-type beta-trefoil; Region: RICIN; smart00458 446462008454 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462008455 putative sugar binding sites [chemical binding]; other site 446462008456 Q-X-W motif; other site 446462008457 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446462008458 Switch II region; other site 446462008459 G4 box; other site 446462008460 G5 box; other site 446462008461 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 446462008462 ATP cone domain; Region: ATP-cone; pfam03477 446462008463 ATP cone domain; Region: ATP-cone; pfam03477 446462008464 Class I ribonucleotide reductase; Region: RNR_I; cd01679 446462008465 active site 446462008466 dimer interface [polypeptide binding]; other site 446462008467 catalytic residues [active] 446462008468 effector binding site; other site 446462008469 R2 peptide binding site; other site 446462008470 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446462008471 dimer interface [polypeptide binding]; other site 446462008472 putative radical transfer pathway; other site 446462008473 diiron center [ion binding]; other site 446462008474 tyrosyl radical; other site 446462008475 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 446462008476 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 446462008477 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462008478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462008479 non-specific DNA binding site [nucleotide binding]; other site 446462008480 salt bridge; other site 446462008481 sequence-specific DNA binding site [nucleotide binding]; other site 446462008482 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 446462008483 MMPL family; Region: MMPL; pfam03176 446462008484 MMPL family; Region: MMPL; pfam03176 446462008485 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 446462008486 active site 446462008487 catalytic triad [active] 446462008488 oxyanion hole [active] 446462008489 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462008490 anti sigma factor interaction site; other site 446462008491 regulatory phosphorylation site [posttranslational modification]; other site 446462008492 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 446462008493 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462008494 substrate binding site [chemical binding]; other site 446462008495 oxyanion hole (OAH) forming residues; other site 446462008496 trimer interface [polypeptide binding]; other site 446462008497 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 446462008498 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462008499 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446462008500 putative NAD(P) binding site [chemical binding]; other site 446462008501 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462008502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462008504 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446462008505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462008506 Walker A/P-loop; other site 446462008507 ATP binding site [chemical binding]; other site 446462008508 Q-loop/lid; other site 446462008509 ABC transporter signature motif; other site 446462008510 Walker B; other site 446462008511 D-loop; other site 446462008512 H-loop/switch region; other site 446462008513 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 446462008514 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462008515 O-methyltransferase; Region: Methyltransf_2; pfam00891 446462008516 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462008517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462008518 DNA binding residues [nucleotide binding] 446462008519 dimerization interface [polypeptide binding]; other site 446462008520 Erythronolide synthase docking; Region: Docking; pfam08990 446462008521 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008522 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 446462008523 active site 446462008524 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462008525 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008526 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462008527 NADP binding site [chemical binding]; other site 446462008528 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008529 active site 446462008530 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008531 Erythronolide synthase docking; Region: Docking; pfam08990 446462008532 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462008533 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008534 active site 446462008535 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008536 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008537 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008538 putative NADP binding site [chemical binding]; other site 446462008539 KR domain; Region: KR; pfam08659 446462008540 active site 446462008541 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008542 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008543 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462008544 active site 446462008545 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462008546 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008547 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008548 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008549 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008550 putative NADP binding site [chemical binding]; other site 446462008551 active site 446462008552 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008553 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446462008554 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 446462008555 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 446462008556 hypothetical protein; Provisional; Region: PRK06184 446462008557 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462008558 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446462008559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462008560 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446462008561 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462008562 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462008563 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 446462008564 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462008565 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446462008566 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446462008567 active site 446462008568 FkbH-like domain; Region: FkbH; TIGR01686 446462008569 Acid Phosphatase; Region: Acid_PPase; cl17256 446462008570 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446462008571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008572 S-adenosylmethionine binding site [chemical binding]; other site 446462008573 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462008574 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462008575 AAA ATPase domain; Region: AAA_16; pfam13191 446462008576 AAA ATPase domain; Region: AAA_16; pfam13191 446462008577 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462008578 YCII-related domain; Region: YCII; cl00999 446462008579 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 446462008580 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 446462008581 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 446462008582 Dehydroquinase class II; Region: DHquinase_II; pfam01220 446462008583 active site 446462008584 trimer interface [polypeptide binding]; other site 446462008585 dimer interface [polypeptide binding]; other site 446462008586 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 446462008587 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446462008588 inhibitor-cofactor binding pocket; inhibition site 446462008589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462008590 catalytic residue [active] 446462008591 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462008592 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462008593 acyl-activating enzyme (AAE) consensus motif; other site 446462008594 AMP binding site [chemical binding]; other site 446462008595 active site 446462008596 CoA binding site [chemical binding]; other site 446462008597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008598 NAD(P) binding site [chemical binding]; other site 446462008599 active site 446462008600 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008601 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008602 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462008603 active site 446462008604 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462008605 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008606 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008608 Enoylreductase; Region: PKS_ER; smart00829 446462008609 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446462008610 NAD(P) binding site [chemical binding]; other site 446462008611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008612 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008613 NAD(P) binding site [chemical binding]; other site 446462008614 active site 446462008615 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008616 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462008617 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008618 active site 446462008619 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008620 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008621 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008622 putative NADP binding site [chemical binding]; other site 446462008623 KR domain; Region: KR; pfam08659 446462008624 active site 446462008625 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008626 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008627 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462008628 active site 446462008629 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462008630 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008631 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008632 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008633 putative NADP binding site [chemical binding]; other site 446462008634 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008635 active site 446462008636 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008637 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462008638 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008639 active site 446462008640 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008641 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008642 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446462008643 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462008644 homodimer interface [polypeptide binding]; other site 446462008645 active site 446462008646 TDP-binding site; other site 446462008647 acceptor substrate-binding pocket; other site 446462008648 short chain dehydrogenase; Provisional; Region: PRK07109 446462008649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008650 NAD(P) binding site [chemical binding]; other site 446462008651 active site 446462008652 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 446462008653 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008654 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446462008655 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446462008656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462008657 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462008658 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462008659 DNA binding residues [nucleotide binding] 446462008660 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462008661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008662 S-adenosylmethionine binding site [chemical binding]; other site 446462008663 RibD C-terminal domain; Region: RibD_C; cl17279 446462008664 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446462008665 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446462008666 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 446462008667 putative active site [active] 446462008668 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 446462008669 substrate binding site [chemical binding]; other site 446462008670 active site 446462008671 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 446462008672 metal binding site [ion binding]; metal-binding site 446462008673 ligand binding site [chemical binding]; other site 446462008674 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446462008675 Cellulose binding domain; Region: CBM_2; cl17741 446462008676 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446462008677 Cellulose binding domain; Region: CBM_2; cl17741 446462008678 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 446462008679 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462008680 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446462008681 Cellulose binding domain; Region: CBM_2; pfam00553 446462008682 Potato inhibitor I family; Region: potato_inhibit; pfam00280 446462008683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462008684 Histidine kinase; Region: HisKA_3; pfam07730 446462008685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462008686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462008687 active site 446462008688 phosphorylation site [posttranslational modification] 446462008689 intermolecular recognition site; other site 446462008690 dimerization interface [polypeptide binding]; other site 446462008691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462008692 DNA binding residues [nucleotide binding] 446462008693 dimerization interface [polypeptide binding]; other site 446462008694 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446462008695 putative metal binding residues [ion binding]; other site 446462008696 signature motif; other site 446462008697 dimer interface [polypeptide binding]; other site 446462008698 active site 446462008699 polyP binding site; other site 446462008700 substrate binding site [chemical binding]; other site 446462008701 acceptor-phosphate pocket; other site 446462008702 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 446462008703 CotH protein; Region: CotH; pfam08757 446462008704 Cellulose binding domain; Region: CBM_2; pfam00553 446462008705 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 446462008706 classical (c) SDRs; Region: SDR_c; cd05233 446462008707 NAD(P) binding site [chemical binding]; other site 446462008708 active site 446462008709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462008710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462008711 active site 446462008712 catalytic tetrad [active] 446462008713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462008714 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462008715 salt bridge; other site 446462008716 non-specific DNA binding site [nucleotide binding]; other site 446462008717 sequence-specific DNA binding site [nucleotide binding]; other site 446462008718 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 446462008719 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 446462008720 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 446462008721 Ligand Binding Site [chemical binding]; other site 446462008722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462008723 dimer interface [polypeptide binding]; other site 446462008724 phosphorylation site [posttranslational modification] 446462008725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462008726 ATP binding site [chemical binding]; other site 446462008727 Mg2+ binding site [ion binding]; other site 446462008728 G-X-G motif; other site 446462008729 K+-transporting ATPase, c chain; Region: KdpC; cl00944 446462008730 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 446462008731 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446462008732 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446462008733 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 446462008734 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446462008735 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446462008736 active site 446462008737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462008738 substrate binding site [chemical binding]; other site 446462008739 catalytic residues [active] 446462008740 dimer interface [polypeptide binding]; other site 446462008741 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462008742 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462008743 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462008744 anti sigma factor interaction site; other site 446462008745 regulatory phosphorylation site [posttranslational modification]; other site 446462008746 Electron transfer DM13; Region: DM13; pfam10517 446462008747 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446462008748 putative active site [active] 446462008749 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 446462008750 catalytic residues [active] 446462008751 catalytic nucleophile [active] 446462008752 Recombinase; Region: Recombinase; pfam07508 446462008753 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 446462008754 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446462008755 active site 446462008756 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 446462008757 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446462008758 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446462008759 Phage-related protein [Function unknown]; Region: COG5412 446462008760 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 446462008761 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 446462008762 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 446462008763 Phage terminase, small subunit; Region: Terminase_4; pfam05119 446462008764 Pleckstrin homology-like domain; Region: PH-like; cl17171 446462008765 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446462008766 Domain of unknown function (DUF932); Region: DUF932; cl12129 446462008767 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 446462008768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462008769 DDE superfamily endonuclease; Region: DDE_4; pfam13359 446462008770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 446462008771 Phosphotransferase enzyme family; Region: APH; pfam01636 446462008772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008773 S-adenosylmethionine binding site [chemical binding]; other site 446462008774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008775 S-adenosylmethionine binding site [chemical binding]; other site 446462008776 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462008777 Cytochrome P450; Region: p450; cl12078 446462008778 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462008779 Cytochrome P450; Region: p450; cl12078 446462008780 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446462008781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462008782 S-adenosylmethionine binding site [chemical binding]; other site 446462008783 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446462008784 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462008785 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462008786 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446462008787 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446462008788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462008789 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446462008790 active site 446462008791 FkbH-like domain; Region: FkbH; TIGR01686 446462008792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462008793 active site 446462008794 motif I; other site 446462008795 motif II; other site 446462008796 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 446462008797 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 446462008798 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462008799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462008800 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 446462008801 Dehydroquinase class II; Region: DHquinase_II; pfam01220 446462008802 trimer interface [polypeptide binding]; other site 446462008803 active site 446462008804 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 446462008805 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446462008806 inhibitor-cofactor binding pocket; inhibition site 446462008807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462008808 catalytic residue [active] 446462008809 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462008810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462008811 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462008812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462008813 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 446462008814 active site 446462008815 motif I; other site 446462008816 motif II; other site 446462008817 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446462008818 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 446462008819 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462008820 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462008821 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462008822 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446462008823 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008824 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462008825 active site 446462008826 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462008827 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008828 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008830 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446462008831 Enoylreductase; Region: PKS_ER; smart00829 446462008832 NAD(P) binding site [chemical binding]; other site 446462008833 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008834 putative NADP binding site [chemical binding]; other site 446462008835 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008836 active site 446462008837 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008838 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462008839 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008840 active site 446462008841 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008842 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008843 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008844 putative NADP binding site [chemical binding]; other site 446462008845 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008846 active site 446462008847 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008848 Erythronolide synthase docking; Region: Docking; pfam08990 446462008849 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462008850 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008851 active site 446462008852 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008853 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008854 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008855 putative NADP binding site [chemical binding]; other site 446462008856 KR domain; Region: KR; pfam08659 446462008857 active site 446462008858 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008859 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008860 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462008861 active site 446462008862 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008863 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462008864 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462008865 NADP binding site [chemical binding]; other site 446462008866 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008867 active site 446462008868 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008869 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462008870 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462008871 acyl-activating enzyme (AAE) consensus motif; other site 446462008872 AMP binding site [chemical binding]; other site 446462008873 active site 446462008874 CoA binding site [chemical binding]; other site 446462008875 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008876 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008877 putative NADP binding site [chemical binding]; other site 446462008878 active site 446462008879 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008880 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462008881 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008882 active site 446462008883 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008884 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008886 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446462008887 Enoylreductase; Region: PKS_ER; smart00829 446462008888 NAD(P) binding site [chemical binding]; other site 446462008889 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008890 putative NADP binding site [chemical binding]; other site 446462008891 KR domain; Region: KR; pfam08659 446462008892 active site 446462008893 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008894 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462008895 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008896 active site 446462008897 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008898 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462008899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008900 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446462008901 Enoylreductase; Region: PKS_ER; smart00829 446462008902 NAD(P) binding site [chemical binding]; other site 446462008903 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462008904 putative NADP binding site [chemical binding]; other site 446462008905 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008906 active site 446462008907 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008908 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462008909 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462008910 active site 446462008911 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462008912 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462008913 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462008914 NADP binding site [chemical binding]; other site 446462008915 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462008916 active site 446462008917 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462008918 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446462008919 dimer interface [polypeptide binding]; other site 446462008920 active site 446462008921 metal binding site [ion binding]; metal-binding site 446462008922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462008923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462008924 DNA binding residues [nucleotide binding] 446462008925 dimerization interface [polypeptide binding]; other site 446462008926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462008927 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446462008928 Coenzyme A binding pocket [chemical binding]; other site 446462008929 Cellulose binding domain; Region: CBM_2; pfam00553 446462008930 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 446462008931 active site 446462008932 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 446462008933 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 446462008934 active site 446462008935 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 446462008936 Cellulose binding domain; Region: CBM_2; pfam00553 446462008937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462008938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462008939 DNA binding site [nucleotide binding] 446462008940 domain linker motif; other site 446462008941 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462008942 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462008943 Coenzyme A binding pocket [chemical binding]; other site 446462008944 Isochorismatase family; Region: Isochorismatase; pfam00857 446462008945 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 446462008946 catalytic triad [active] 446462008947 conserved cis-peptide bond; other site 446462008948 Predicted ATPase [General function prediction only]; Region: COG3903 446462008949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462008950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462008951 WHG domain; Region: WHG; pfam13305 446462008952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462008953 KR domain; Region: KR; pfam08659 446462008954 NAD(P) binding site [chemical binding]; other site 446462008955 active site 446462008956 Tautomerase enzyme; Region: Tautomerase; pfam01361 446462008957 active site 1 [active] 446462008958 dimer interface [polypeptide binding]; other site 446462008959 hexamer interface [polypeptide binding]; other site 446462008960 active site 2 [active] 446462008961 RibD C-terminal domain; Region: RibD_C; cl17279 446462008962 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462008963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462008964 active site 446462008965 phosphorylation site [posttranslational modification] 446462008966 intermolecular recognition site; other site 446462008967 dimerization interface [polypeptide binding]; other site 446462008968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462008969 dimerization interface [polypeptide binding]; other site 446462008970 DNA binding residues [nucleotide binding] 446462008971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462008972 Histidine kinase; Region: HisKA_3; pfam07730 446462008973 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462008974 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446462008975 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 446462008976 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446462008977 metal ion-dependent adhesion site (MIDAS); other site 446462008978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462008979 Walker A motif; other site 446462008980 ATP binding site [chemical binding]; other site 446462008981 Walker B motif; other site 446462008982 arginine finger; other site 446462008983 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446462008984 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462008985 Helix-turn-helix domain; Region: HTH_38; pfam13936 446462008986 Predicted transcriptional regulators [Transcription]; Region: COG1510 446462008987 MarR family; Region: MarR_2; cl17246 446462008988 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 446462008989 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446462008990 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462008991 Helix-turn-helix domain; Region: HTH_18; pfam12833 446462008992 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446462008993 Ligand Binding Site [chemical binding]; other site 446462008994 Molecular Tunnel; other site 446462008995 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 446462008996 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 446462008997 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446462008998 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446462008999 conserved cys residue [active] 446462009000 Cupin domain; Region: Cupin_2; cl17218 446462009001 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 446462009002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009003 short chain dehydrogenase; Provisional; Region: PRK06197 446462009004 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446462009005 putative NAD(P) binding site [chemical binding]; other site 446462009006 active site 446462009007 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 446462009008 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462009009 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 446462009010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462009011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462009012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462009013 DNA binding site [nucleotide binding] 446462009014 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462009015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462009016 NmrA-like family; Region: NmrA; pfam05368 446462009017 NAD(P) binding site [chemical binding]; other site 446462009018 active site 446462009019 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462009020 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446462009021 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446462009022 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446462009023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462009024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462009025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462009026 NAD(P) binding site [chemical binding]; other site 446462009027 active site 446462009028 Carboxylesterase family; Region: COesterase; pfam00135 446462009029 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446462009030 substrate binding pocket [chemical binding]; other site 446462009031 catalytic triad [active] 446462009032 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446462009033 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462009034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462009035 Histidine kinase; Region: HisKA_3; pfam07730 446462009036 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462009037 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 446462009038 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446462009039 putative NAD(P) binding site [chemical binding]; other site 446462009040 putative substrate binding site [chemical binding]; other site 446462009041 catalytic Zn binding site [ion binding]; other site 446462009042 structural Zn binding site [ion binding]; other site 446462009043 dimer interface [polypeptide binding]; other site 446462009044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462009045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009046 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446462009047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462009048 Coenzyme A binding pocket [chemical binding]; other site 446462009049 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446462009050 RibD C-terminal domain; Region: RibD_C; cl17279 446462009051 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462009052 active site 446462009053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462009054 catalytic tetrad [active] 446462009055 Cupin; Region: Cupin_6; pfam12852 446462009056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462009057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462009058 DinB superfamily; Region: DinB_2; pfam12867 446462009059 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446462009060 putative phosphoketolase; Provisional; Region: PRK05261 446462009061 XFP N-terminal domain; Region: XFP_N; pfam09364 446462009062 XFP C-terminal domain; Region: XFP_C; pfam09363 446462009063 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 446462009064 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446462009065 nudix motif; other site 446462009066 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 446462009067 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 446462009068 PYR/PP interface [polypeptide binding]; other site 446462009069 dimer interface [polypeptide binding]; other site 446462009070 tetramer interface [polypeptide binding]; other site 446462009071 TPP binding site [chemical binding]; other site 446462009072 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446462009073 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446462009074 TPP-binding site [chemical binding]; other site 446462009075 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462009076 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462009077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462009078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462009079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462009080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462009081 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 446462009082 putative dimerization interface [polypeptide binding]; other site 446462009083 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446462009084 active site 446462009085 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446462009086 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462009087 DNA binding site [nucleotide binding] 446462009088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462009089 domain linker motif; other site 446462009090 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462009091 ligand binding site [chemical binding]; other site 446462009092 dimerization interface [polypeptide binding]; other site 446462009093 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 446462009094 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 446462009095 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 446462009096 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 446462009097 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446462009098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462009099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462009101 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462009102 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 446462009103 Predicted esterase [General function prediction only]; Region: COG0627 446462009104 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 446462009105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462009106 active site 446462009107 Predicted transcriptional regulators [Transcription]; Region: COG1725 446462009108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462009109 DNA-binding site [nucleotide binding]; DNA binding site 446462009110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462009111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009112 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446462009113 PspC domain; Region: PspC; pfam04024 446462009114 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 446462009115 Ligand binding site; other site 446462009116 Putative Catalytic site; other site 446462009117 DXD motif; other site 446462009118 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446462009119 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446462009120 nudix motif; other site 446462009121 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462009122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462009123 non-specific DNA binding site [nucleotide binding]; other site 446462009124 salt bridge; other site 446462009125 sequence-specific DNA binding site [nucleotide binding]; other site 446462009126 Cupin domain; Region: Cupin_2; pfam07883 446462009127 thymidine kinase; Provisional; Region: PRK04296 446462009128 Predicted transcriptional regulators [Transcription]; Region: COG1695 446462009129 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446462009130 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 446462009131 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446462009132 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 446462009133 putative active site [active] 446462009134 catalytic site [active] 446462009135 putative metal binding site [ion binding]; other site 446462009136 PAS domain; Region: PAS; smart00091 446462009137 PAS domain; Region: PAS_9; pfam13426 446462009138 PAS fold; Region: PAS_3; pfam08447 446462009139 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462009140 putative active site [active] 446462009141 heme pocket [chemical binding]; other site 446462009142 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462009143 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462009144 metal binding site [ion binding]; metal-binding site 446462009145 active site 446462009146 I-site; other site 446462009147 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462009148 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446462009149 active site 446462009150 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446462009151 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 446462009152 DNA binding site [nucleotide binding] 446462009153 heterodimer interface [polypeptide binding]; other site 446462009154 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462009155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462009156 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 446462009157 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 446462009158 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446462009159 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446462009160 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462009161 dimerization interface [polypeptide binding]; other site 446462009162 putative DNA binding site [nucleotide binding]; other site 446462009163 putative Zn2+ binding site [ion binding]; other site 446462009164 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446462009165 arsenical-resistance protein; Region: acr3; TIGR00832 446462009166 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446462009167 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446462009168 active site 446462009169 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 446462009170 amidase; Provisional; Region: PRK12470 446462009171 Amidase; Region: Amidase; cl11426 446462009172 Amidase; Region: Amidase; cl11426 446462009173 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446462009174 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446462009175 CGNR zinc finger; Region: zf-CGNR; pfam11706 446462009176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446462009177 classical (c) SDRs; Region: SDR_c; cd05233 446462009178 NAD(P) binding site [chemical binding]; other site 446462009179 active site 446462009180 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446462009181 active site 446462009182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462009183 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462009184 sequence-specific DNA binding site [nucleotide binding]; other site 446462009185 salt bridge; other site 446462009186 Predicted transcriptional regulator [Transcription]; Region: COG2378 446462009187 HTH domain; Region: HTH_11; pfam08279 446462009188 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446462009189 hypothetical protein; Provisional; Region: PRK07236 446462009190 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462009191 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 446462009192 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446462009193 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446462009194 nudix motif; other site 446462009195 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446462009196 active site 446462009197 catalytic site [active] 446462009198 substrate binding site [chemical binding]; other site 446462009199 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462009200 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 446462009201 active site 446462009202 DNA binding site [nucleotide binding] 446462009203 Int/Topo IB signature motif; other site 446462009204 Helix-turn-helix domain; Region: HTH_18; pfam12833 446462009205 conserved hypothetical protein; Region: TIGR03843 446462009206 conserved hypothetical protein; Region: TIGR03847 446462009207 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446462009208 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462009209 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 446462009210 dimer interface [polypeptide binding]; other site 446462009211 catalytic triad [active] 446462009212 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462009213 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 446462009214 putative sugar binding sites [chemical binding]; other site 446462009215 Q-X-W motif; other site 446462009216 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 446462009217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462009218 active site 446462009219 motif I; other site 446462009220 motif II; other site 446462009221 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 446462009222 putative active site [active] 446462009223 putative substrate binding site [chemical binding]; other site 446462009224 ATP binding site [chemical binding]; other site 446462009225 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462009226 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462009227 active site 446462009228 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446462009229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462009230 Walker A/P-loop; other site 446462009231 ATP binding site [chemical binding]; other site 446462009232 Q-loop/lid; other site 446462009233 ABC transporter signature motif; other site 446462009234 Walker B; other site 446462009235 D-loop; other site 446462009236 H-loop/switch region; other site 446462009237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462009238 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462009239 Walker A/P-loop; other site 446462009240 ATP binding site [chemical binding]; other site 446462009241 Q-loop/lid; other site 446462009242 ABC transporter signature motif; other site 446462009243 Walker B; other site 446462009244 D-loop; other site 446462009245 H-loop/switch region; other site 446462009246 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462009247 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462009248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462009249 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462009250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462009251 dimer interface [polypeptide binding]; other site 446462009252 conserved gate region; other site 446462009253 putative PBP binding loops; other site 446462009254 ABC-ATPase subunit interface; other site 446462009255 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462009256 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446462009257 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 446462009258 SxDxEG motif; other site 446462009259 active site 446462009260 metal binding site [ion binding]; metal-binding site 446462009261 homopentamer interface [polypeptide binding]; other site 446462009262 hypothetical protein; Provisional; Region: PRK07906 446462009263 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446462009264 putative metal binding site [ion binding]; other site 446462009265 Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441 446462009266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462009267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462009268 DNA binding site [nucleotide binding] 446462009269 domain linker motif; other site 446462009270 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446462009271 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446462009272 active site 446462009273 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462009274 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446462009275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462009276 putative PBP binding loops; other site 446462009277 ABC-ATPase subunit interface; other site 446462009278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462009279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462009280 dimer interface [polypeptide binding]; other site 446462009281 conserved gate region; other site 446462009282 putative PBP binding loops; other site 446462009283 ABC-ATPase subunit interface; other site 446462009284 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462009285 active site 446462009286 DNA binding site [nucleotide binding] 446462009287 Int/Topo IB signature motif; other site 446462009288 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462009289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462009290 non-specific DNA binding site [nucleotide binding]; other site 446462009291 salt bridge; other site 446462009292 sequence-specific DNA binding site [nucleotide binding]; other site 446462009293 NACHT domain; Region: NACHT; pfam05729 446462009294 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 446462009295 EspG family; Region: ESX-1_EspG; pfam14011 446462009296 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 446462009297 HTH domain; Region: HTH_11; pfam08279 446462009298 WYL domain; Region: WYL; pfam13280 446462009299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462009300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462009301 active site 446462009302 catalytic tetrad [active] 446462009303 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446462009304 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462009305 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462009306 NAD(P) binding site [chemical binding]; other site 446462009307 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446462009308 nudix motif; other site 446462009309 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446462009310 homotrimer interaction site [polypeptide binding]; other site 446462009311 putative active site [active] 446462009312 HTH domain; Region: HTH_11; pfam08279 446462009313 WYL domain; Region: WYL; pfam13280 446462009314 Cellulose binding domain; Region: CBM_2; pfam00553 446462009315 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 446462009316 active site 446462009317 catalytic triad [active] 446462009318 oxyanion hole [active] 446462009319 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446462009320 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462009321 DNA binding residues [nucleotide binding] 446462009322 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462009323 DNA binding residues [nucleotide binding] 446462009324 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462009325 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462009326 DNA binding residues [nucleotide binding] 446462009327 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446462009328 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 446462009329 putative active site [active] 446462009330 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 446462009331 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 446462009332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462009333 S-adenosylmethionine binding site [chemical binding]; other site 446462009334 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 446462009335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462009336 Walker A/P-loop; other site 446462009337 ATP binding site [chemical binding]; other site 446462009338 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462009339 active site 446462009340 metal binding site [ion binding]; metal-binding site 446462009341 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446462009342 hypothetical protein; Provisional; Region: PRK06834 446462009343 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446462009344 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462009345 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 446462009346 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 446462009347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462009348 active site 446462009349 metal binding site [ion binding]; metal-binding site 446462009350 hexamer interface [polypeptide binding]; other site 446462009351 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462009352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462009353 substrate binding pocket [chemical binding]; other site 446462009354 membrane-bound complex binding site; other site 446462009355 hinge residues; other site 446462009356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462009357 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462009358 active site 446462009359 ATP binding site [chemical binding]; other site 446462009360 substrate binding site [chemical binding]; other site 446462009361 activation loop (A-loop); other site 446462009362 Double zinc ribbon; Region: DZR; pfam12773 446462009363 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 446462009364 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446462009365 Protein phosphatase 2C; Region: PP2C; pfam00481 446462009366 active site 446462009367 MarR family; Region: MarR; pfam01047 446462009368 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462009369 Cytochrome P450; Region: p450; cl12078 446462009370 Phosphotransferase enzyme family; Region: APH; pfam01636 446462009371 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 446462009372 Prostaglandin dehydrogenases; Region: PGDH; cd05288 446462009373 NAD(P) binding site [chemical binding]; other site 446462009374 substrate binding site [chemical binding]; other site 446462009375 dimer interface [polypeptide binding]; other site 446462009376 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462009377 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462009378 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 446462009379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462009380 ATP binding site [chemical binding]; other site 446462009381 putative Mg++ binding site [ion binding]; other site 446462009382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462009383 nucleotide binding region [chemical binding]; other site 446462009384 ATP-binding site [chemical binding]; other site 446462009385 Helicase associated domain (HA2); Region: HA2; pfam04408 446462009386 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 446462009387 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446462009388 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446462009389 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446462009390 tetramer interface [polypeptide binding]; other site 446462009391 active site 446462009392 Mg2+/Mn2+ binding site [ion binding]; other site 446462009393 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446462009394 active site 446462009395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462009396 catalytic core [active] 446462009397 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 446462009398 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462009399 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 446462009400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462009401 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462009402 active site 446462009403 catalytic tetrad [active] 446462009404 Uncharacterized conserved protein [Function unknown]; Region: COG4748 446462009405 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 446462009406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462009407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446462009408 Coenzyme A binding pocket [chemical binding]; other site 446462009409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462009410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009411 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446462009412 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 446462009413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462009414 Walker A/P-loop; other site 446462009415 ATP binding site [chemical binding]; other site 446462009416 Q-loop/lid; other site 446462009417 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446462009418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462009419 Walker A/P-loop; other site 446462009420 ATP binding site [chemical binding]; other site 446462009421 Q-loop/lid; other site 446462009422 ABC transporter signature motif; other site 446462009423 Walker B; other site 446462009424 D-loop; other site 446462009425 H-loop/switch region; other site 446462009426 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446462009427 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446462009428 FAD binding pocket [chemical binding]; other site 446462009429 FAD binding motif [chemical binding]; other site 446462009430 phosphate binding motif [ion binding]; other site 446462009431 NAD binding pocket [chemical binding]; other site 446462009432 AAA ATPase domain; Region: AAA_16; pfam13191 446462009433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462009434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462009435 DNA binding residues [nucleotide binding] 446462009436 dimerization interface [polypeptide binding]; other site 446462009437 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446462009438 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462009439 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462009440 Cellulose binding domain; Region: CBM_2; pfam00553 446462009441 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 446462009442 active site 446462009443 catalytic triad [active] 446462009444 oxyanion hole [active] 446462009445 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462009446 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462009447 putative sugar binding sites [chemical binding]; other site 446462009448 Q-X-W motif; other site 446462009449 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462009450 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462009451 substrate binding pocket [chemical binding]; other site 446462009452 membrane-bound complex binding site; other site 446462009453 hinge residues; other site 446462009454 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 446462009455 active site 446462009456 ligand binding site [chemical binding]; other site 446462009457 homodimer interface [polypeptide binding]; other site 446462009458 NAD(P) binding site [chemical binding]; other site 446462009459 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 446462009460 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 446462009461 putative uracil binding site [chemical binding]; other site 446462009462 putative active site [active] 446462009463 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446462009464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462009465 putative substrate translocation pore; other site 446462009466 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 446462009467 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446462009468 active site 446462009469 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462009470 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446462009471 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462009472 calcium binding site 2 [ion binding]; other site 446462009473 active site 446462009474 catalytic triad [active] 446462009475 calcium binding site 1 [ion binding]; other site 446462009476 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462009477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462009478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462009479 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462009480 acyl-activating enzyme (AAE) consensus motif; other site 446462009481 AMP binding site [chemical binding]; other site 446462009482 active site 446462009483 CoA binding site [chemical binding]; other site 446462009484 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446462009485 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462009486 DNA binding residues [nucleotide binding] 446462009487 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 446462009488 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446462009489 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446462009490 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446462009491 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462009492 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 446462009493 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462009494 active site 446462009495 catalytic residues [active] 446462009496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462009497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009498 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462009499 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462009500 active site 446462009501 catalytic tetrad [active] 446462009502 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446462009503 hypothetical protein; Provisional; Region: PRK01346 446462009504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462009505 Coenzyme A binding pocket [chemical binding]; other site 446462009506 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 446462009507 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 446462009508 inhibitor binding site; inhibition site 446462009509 active site 446462009510 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462009511 DNA binding site [nucleotide binding] 446462009512 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462009513 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462009514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446462009515 binding surface 446462009516 TPR motif; other site 446462009517 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462009518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462009519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462009520 DNA binding residues [nucleotide binding] 446462009521 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462009522 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462009523 DNA binding residues [nucleotide binding] 446462009524 dimerization interface [polypeptide binding]; other site 446462009525 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462009526 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462009527 Cytochrome P450; Region: p450; cl12078 446462009528 Condensation domain; Region: Condensation; pfam00668 446462009529 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009530 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009531 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009532 acyl-activating enzyme (AAE) consensus motif; other site 446462009533 AMP binding site [chemical binding]; other site 446462009534 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 446462009535 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009536 acyl-activating enzyme (AAE) consensus motif; other site 446462009537 AMP binding site [chemical binding]; other site 446462009538 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009539 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 446462009540 Condensation domain; Region: Condensation; pfam00668 446462009541 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009542 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009543 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462009544 acyl-activating enzyme (AAE) consensus motif; other site 446462009545 AMP binding site [chemical binding]; other site 446462009546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009547 Condensation domain; Region: Condensation; pfam00668 446462009548 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009549 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009550 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009551 acyl-activating enzyme (AAE) consensus motif; other site 446462009552 AMP binding site [chemical binding]; other site 446462009553 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009554 MbtH-like protein; Region: MbtH; cl01279 446462009555 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 446462009556 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 446462009557 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009558 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462009559 acyl-activating enzyme (AAE) consensus motif; other site 446462009560 AMP binding site [chemical binding]; other site 446462009561 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446462009562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462009563 catalytic residue [active] 446462009564 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 446462009565 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 446462009566 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 446462009567 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 446462009568 AAA domain; Region: AAA_18; pfam13238 446462009569 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 446462009570 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 446462009571 cobalt transport protein CbiN; Provisional; Region: PRK02898 446462009572 Cobalt transport protein; Region: CbiQ; cl00463 446462009573 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446462009574 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446462009575 Walker A/P-loop; other site 446462009576 ATP binding site [chemical binding]; other site 446462009577 Q-loop/lid; other site 446462009578 ABC transporter signature motif; other site 446462009579 Walker B; other site 446462009580 D-loop; other site 446462009581 H-loop/switch region; other site 446462009582 hypothetical protein; Validated; Region: PRK06217 446462009583 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462009584 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446462009585 DNA binding residues [nucleotide binding] 446462009586 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462009587 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 446462009588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462009589 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446462009590 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446462009591 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 446462009592 putative hydrophobic ligand binding site [chemical binding]; other site 446462009593 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462009594 Cytochrome P450; Region: p450; cl12078 446462009595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 446462009596 Condensation domain; Region: Condensation; pfam00668 446462009597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462009598 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009599 acyl-activating enzyme (AAE) consensus motif; other site 446462009600 AMP binding site [chemical binding]; other site 446462009601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462009602 Condensation domain; Region: Condensation; pfam00668 446462009603 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009604 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009605 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009606 acyl-activating enzyme (AAE) consensus motif; other site 446462009607 AMP binding site [chemical binding]; other site 446462009608 Condensation domain; Region: Condensation; pfam00668 446462009609 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009610 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009611 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009612 acyl-activating enzyme (AAE) consensus motif; other site 446462009613 AMP binding site [chemical binding]; other site 446462009614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009615 Condensation domain; Region: Condensation; pfam00668 446462009616 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009617 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009618 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009619 acyl-activating enzyme (AAE) consensus motif; other site 446462009620 AMP binding site [chemical binding]; other site 446462009621 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009622 Condensation domain; Region: Condensation; pfam00668 446462009623 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009624 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009625 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009626 acyl-activating enzyme (AAE) consensus motif; other site 446462009627 AMP binding site [chemical binding]; other site 446462009628 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009629 Condensation domain; Region: Condensation; pfam00668 446462009630 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009631 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009632 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009633 acyl-activating enzyme (AAE) consensus motif; other site 446462009634 AMP binding site [chemical binding]; other site 446462009635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462009636 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 446462009637 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009638 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009639 acyl-activating enzyme (AAE) consensus motif; other site 446462009640 AMP binding site [chemical binding]; other site 446462009641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009642 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 446462009643 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462009644 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 446462009645 Walker A/P-loop; other site 446462009646 ATP binding site [chemical binding]; other site 446462009647 Q-loop/lid; other site 446462009648 ABC transporter signature motif; other site 446462009649 Walker B; other site 446462009650 D-loop; other site 446462009651 H-loop/switch region; other site 446462009652 AMMECR1; Region: AMMECR1; cl00911 446462009653 Subtilisin inhibitor-like; Region: SSI; cl11594 446462009654 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462009655 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462009656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462009657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462009658 NAD(P) binding site [chemical binding]; other site 446462009659 active site 446462009660 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462009661 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462009663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462009664 FtsX-like permease family; Region: FtsX; pfam02687 446462009665 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 446462009666 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462009667 Walker A/P-loop; other site 446462009668 ATP binding site [chemical binding]; other site 446462009669 Q-loop/lid; other site 446462009670 ABC transporter signature motif; other site 446462009671 Walker B; other site 446462009672 D-loop; other site 446462009673 H-loop/switch region; other site 446462009674 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446462009675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462009676 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446462009677 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446462009678 hydrophobic ligand binding site; other site 446462009679 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462009680 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 446462009681 inhibitor-cofactor binding pocket; inhibition site 446462009682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462009683 catalytic residue [active] 446462009684 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462009685 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446462009686 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462009687 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446462009688 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462009689 NAD(P) binding site [chemical binding]; other site 446462009690 catalytic residues [active] 446462009691 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 446462009692 dinuclear metal binding motif [ion binding]; other site 446462009693 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 446462009694 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462009695 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462009696 NAD(P) binding site [chemical binding]; other site 446462009697 catalytic residues [active] 446462009698 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 446462009699 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 446462009700 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462009701 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 446462009702 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446462009703 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446462009704 acyl-activating enzyme (AAE) consensus motif; other site 446462009705 putative AMP binding site [chemical binding]; other site 446462009706 putative active site [active] 446462009707 putative CoA binding site [chemical binding]; other site 446462009708 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446462009709 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446462009710 putative trimer interface [polypeptide binding]; other site 446462009711 putative CoA binding site [chemical binding]; other site 446462009712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462009713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462009714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462009715 dimerization interface [polypeptide binding]; other site 446462009716 SnoaL-like domain; Region: SnoaL_4; pfam13577 446462009717 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462009718 Immunity protein Imm1; Region: Imm1; pfam14430 446462009719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462009720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462009721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462009722 S-adenosylmethionine binding site [chemical binding]; other site 446462009723 Transcription factor WhiB; Region: Whib; pfam02467 446462009724 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462009725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446462009726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462009727 non-specific DNA binding site [nucleotide binding]; other site 446462009728 salt bridge; other site 446462009729 sequence-specific DNA binding site [nucleotide binding]; other site 446462009730 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462009731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462009732 non-specific DNA binding site [nucleotide binding]; other site 446462009733 salt bridge; other site 446462009734 sequence-specific DNA binding site [nucleotide binding]; other site 446462009735 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446462009736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462009737 motif II; other site 446462009738 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446462009739 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446462009740 putative catalytic site [active] 446462009741 putative metal binding site [ion binding]; other site 446462009742 putative phosphate binding site [ion binding]; other site 446462009743 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462009744 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462009745 active site 446462009746 catalytic tetrad [active] 446462009747 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 446462009748 B12 binding site [chemical binding]; other site 446462009749 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 446462009750 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462009751 DDE superfamily endonuclease; Region: DDE_4; pfam13359 446462009752 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 446462009753 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462009754 Cytochrome P450; Region: p450; cl12078 446462009755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462009756 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 446462009757 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446462009758 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 446462009759 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462009760 NAD(P) binding site [chemical binding]; other site 446462009761 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 446462009762 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446462009763 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 446462009764 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462009765 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462009766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462009767 Walker A/P-loop; other site 446462009768 ATP binding site [chemical binding]; other site 446462009769 Q-loop/lid; other site 446462009770 ABC transporter signature motif; other site 446462009771 Walker B; other site 446462009772 D-loop; other site 446462009773 H-loop/switch region; other site 446462009774 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 446462009775 FliG C-terminal domain; Region: FliG_C; pfam01706 446462009776 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 446462009777 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446462009778 substrate binding site [chemical binding]; other site 446462009779 ATP binding site [chemical binding]; other site 446462009780 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 446462009781 active site 446462009782 nucleotide binding site [chemical binding]; other site 446462009783 HIGH motif; other site 446462009784 KMSKS motif; other site 446462009785 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 446462009786 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 446462009787 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 446462009788 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 446462009789 putative active site [active] 446462009790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 446462009791 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 446462009792 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462009793 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462009794 active site 446462009795 CoA binding site [chemical binding]; other site 446462009796 AMP binding site [chemical binding]; other site 446462009797 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 446462009798 putative FMN binding site [chemical binding]; other site 446462009799 NADPH bind site [chemical binding]; other site 446462009800 Condensation domain; Region: Condensation; pfam00668 446462009801 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009802 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009803 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009804 acyl-activating enzyme (AAE) consensus motif; other site 446462009805 AMP binding site [chemical binding]; other site 446462009806 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009807 Condensation domain; Region: Condensation; pfam00668 446462009808 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009809 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446462009810 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 446462009811 acyl-activating enzyme (AAE) consensus motif; other site 446462009812 AMP binding site [chemical binding]; other site 446462009813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009814 Condensation domain; Region: Condensation; pfam00668 446462009815 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009816 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446462009817 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 446462009818 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 446462009819 active site 446462009820 dimer interface [polypeptide binding]; other site 446462009821 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446462009822 Ligand Binding Site [chemical binding]; other site 446462009823 Molecular Tunnel; other site 446462009824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462009825 active site 446462009826 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 446462009827 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462009828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462009829 NAD(P) binding site [chemical binding]; other site 446462009830 active site 446462009831 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009832 Condensation domain; Region: Condensation; pfam00668 446462009833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009834 acyl-CoA synthetase; Validated; Region: PRK05850 446462009835 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 446462009836 acyl-activating enzyme (AAE) consensus motif; other site 446462009837 active site 446462009838 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462009839 Condensation domain; Region: Condensation; pfam00668 446462009840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009841 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009842 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009843 acyl-activating enzyme (AAE) consensus motif; other site 446462009844 AMP binding site [chemical binding]; other site 446462009845 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009846 Condensation domain; Region: Condensation; pfam00668 446462009847 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009848 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462009849 acyl-activating enzyme (AAE) consensus motif; other site 446462009850 AMP binding site [chemical binding]; other site 446462009851 Condensation domain; Region: Condensation; pfam00668 446462009852 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462009853 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009854 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009855 acyl-activating enzyme (AAE) consensus motif; other site 446462009856 AMP binding site [chemical binding]; other site 446462009857 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009858 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462009859 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462009860 active site 446462009861 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462009862 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 446462009863 putative NADP binding site [chemical binding]; other site 446462009864 KR domain; Region: KR; pfam08659 446462009865 active site 446462009866 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009867 Condensation domain; Region: Condensation; pfam00668 446462009868 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462009869 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462009870 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462009871 acyl-activating enzyme (AAE) consensus motif; other site 446462009872 AMP binding site [chemical binding]; other site 446462009873 active site 446462009874 CoA binding site [chemical binding]; other site 446462009875 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009876 Condensation domain; Region: Condensation; pfam00668 446462009877 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009878 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462009879 acyl-activating enzyme (AAE) consensus motif; other site 446462009880 AMP binding site [chemical binding]; other site 446462009881 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009882 Condensation domain; Region: Condensation; pfam00668 446462009883 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462009884 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462009885 acyl-activating enzyme (AAE) consensus motif; other site 446462009886 AMP binding site [chemical binding]; other site 446462009887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462009888 Penicillin amidase; Region: Penicil_amidase; pfam01804 446462009889 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446462009890 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446462009891 active site 446462009892 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446462009893 Condensation domain; Region: Condensation; pfam00668 446462009894 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462009895 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446462009896 Cytochrome P450; Region: p450; cl12078 446462009897 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462009898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462009899 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 446462009900 Walker A/P-loop; other site 446462009901 ATP binding site [chemical binding]; other site 446462009902 Q-loop/lid; other site 446462009903 ABC transporter signature motif; other site 446462009904 Walker B; other site 446462009905 D-loop; other site 446462009906 H-loop/switch region; other site 446462009907 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462009908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462009909 active site 446462009910 phosphorylation site [posttranslational modification] 446462009911 intermolecular recognition site; other site 446462009912 dimerization interface [polypeptide binding]; other site 446462009913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462009914 DNA binding residues [nucleotide binding] 446462009915 dimerization interface [polypeptide binding]; other site 446462009916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462009917 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462009918 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462009919 hypothetical protein; Provisional; Region: PRK07236 446462009920 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462009921 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009922 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 446462009923 ATP binding site [chemical binding]; other site 446462009924 SnoaL-like domain; Region: SnoaL_4; pfam13577 446462009925 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 446462009926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 446462009927 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 446462009928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462009929 ATP binding site [chemical binding]; other site 446462009930 Mg2+ binding site [ion binding]; other site 446462009931 G-X-G motif; other site 446462009932 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 446462009933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462009934 active site 446462009935 phosphorylation site [posttranslational modification] 446462009936 intermolecular recognition site; other site 446462009937 dimerization interface [polypeptide binding]; other site 446462009938 YCII-related domain; Region: YCII; cl00999 446462009939 trehalose synthase; Region: treS_nterm; TIGR02456 446462009940 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 446462009941 active site 446462009942 catalytic site [active] 446462009943 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 446462009944 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462009945 Predicted ATPase [General function prediction only]; Region: COG3910 446462009946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462009947 Walker A/P-loop; other site 446462009948 ATP binding site [chemical binding]; other site 446462009949 Q-loop/lid; other site 446462009950 ABC transporter signature motif; other site 446462009951 Walker B; other site 446462009952 D-loop; other site 446462009953 H-loop/switch region; other site 446462009954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009955 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 446462009956 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446462009957 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 446462009958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462009959 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 446462009960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 446462009961 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446462009962 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 446462009963 oligomer interface [polypeptide binding]; other site 446462009964 metal binding site [ion binding]; metal-binding site 446462009965 metal binding site [ion binding]; metal-binding site 446462009966 putative Cl binding site [ion binding]; other site 446462009967 aspartate ring; other site 446462009968 basic sphincter; other site 446462009969 hydrophobic gate; other site 446462009970 periplasmic entrance; other site 446462009971 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462009972 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462009973 ligand binding site [chemical binding]; other site 446462009974 flexible hinge region; other site 446462009975 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446462009976 putative switch regulator; other site 446462009977 non-specific DNA interactions [nucleotide binding]; other site 446462009978 DNA binding site [nucleotide binding] 446462009979 sequence specific DNA binding site [nucleotide binding]; other site 446462009980 putative cAMP binding site [chemical binding]; other site 446462009981 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446462009982 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446462009983 D-pathway; other site 446462009984 Putative ubiquinol binding site [chemical binding]; other site 446462009985 Low-spin heme (heme b) binding site [chemical binding]; other site 446462009986 Putative water exit pathway; other site 446462009987 Binuclear center (heme o3/CuB) [ion binding]; other site 446462009988 K-pathway; other site 446462009989 Putative proton exit pathway; other site 446462009990 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 446462009991 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462009992 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 446462009993 NAD(P) binding site [chemical binding]; other site 446462009994 catalytic residues [active] 446462009995 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 446462009996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462009997 Walker A/P-loop; other site 446462009998 ATP binding site [chemical binding]; other site 446462009999 Q-loop/lid; other site 446462010000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462010001 ABC transporter signature motif; other site 446462010002 Walker B; other site 446462010003 D-loop; other site 446462010004 H-loop/switch region; other site 446462010005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462010006 Walker A/P-loop; other site 446462010007 ATP binding site [chemical binding]; other site 446462010008 Q-loop/lid; other site 446462010009 ABC transporter signature motif; other site 446462010010 Walker B; other site 446462010011 D-loop; other site 446462010012 H-loop/switch region; other site 446462010013 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 446462010014 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 446462010015 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 446462010016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 446462010017 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 446462010018 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446462010019 intersubunit interface [polypeptide binding]; other site 446462010020 active site 446462010021 Zn2+ binding site [ion binding]; other site 446462010022 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 446462010023 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462010024 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446462010025 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 446462010026 polymerase nucleotide-binding site; other site 446462010027 DNA-binding residues [nucleotide binding]; DNA binding site 446462010028 nucleotide binding site [chemical binding]; other site 446462010029 primase nucleotide-binding site [nucleotide binding]; other site 446462010030 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446462010031 active site 446462010032 substrate binding site [chemical binding]; other site 446462010033 ATP binding site [chemical binding]; other site 446462010034 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 446462010035 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 446462010036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462010037 PAS fold; Region: PAS_3; pfam08447 446462010038 putative active site [active] 446462010039 heme pocket [chemical binding]; other site 446462010040 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462010041 GAF domain; Region: GAF; pfam01590 446462010042 PAS domain S-box; Region: sensory_box; TIGR00229 446462010043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462010044 putative active site [active] 446462010045 heme pocket [chemical binding]; other site 446462010046 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462010047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446462010048 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462010049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462010050 binding surface 446462010051 TPR motif; other site 446462010052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462010053 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446462010054 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462010055 anti sigma factor interaction site; other site 446462010056 regulatory phosphorylation site [posttranslational modification]; other site 446462010057 Response regulator receiver domain; Region: Response_reg; pfam00072 446462010058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462010059 active site 446462010060 phosphorylation site [posttranslational modification] 446462010061 intermolecular recognition site; other site 446462010062 dimerization interface [polypeptide binding]; other site 446462010063 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462010064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462010065 dimer interface [polypeptide binding]; other site 446462010066 phosphorylation site [posttranslational modification] 446462010067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462010068 ATP binding site [chemical binding]; other site 446462010069 Mg2+ binding site [ion binding]; other site 446462010070 G-X-G motif; other site 446462010071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462010072 active site 446462010073 phosphorylation site [posttranslational modification] 446462010074 intermolecular recognition site; other site 446462010075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446462010076 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462010077 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462010078 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462010079 ATP binding site [chemical binding]; other site 446462010080 Mg2+ binding site [ion binding]; other site 446462010081 G-X-G motif; other site 446462010082 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 446462010083 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 446462010084 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 446462010085 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 446462010086 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446462010087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462010088 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446462010089 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446462010090 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462010091 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 446462010092 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462010093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462010094 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 446462010095 substrate binding site [chemical binding]; other site 446462010096 active site 446462010097 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462010098 anti sigma factor interaction site; other site 446462010099 regulatory phosphorylation site [posttranslational modification]; other site 446462010100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462010101 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462010102 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 446462010103 Walker A/P-loop; other site 446462010104 ATP binding site [chemical binding]; other site 446462010105 Q-loop/lid; other site 446462010106 ABC transporter signature motif; other site 446462010107 Walker B; other site 446462010108 D-loop; other site 446462010109 H-loop/switch region; other site 446462010110 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462010111 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462010112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462010113 Walker A/P-loop; other site 446462010114 ATP binding site [chemical binding]; other site 446462010115 Q-loop/lid; other site 446462010116 ABC transporter signature motif; other site 446462010117 Walker B; other site 446462010118 D-loop; other site 446462010119 H-loop/switch region; other site 446462010120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010122 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446462010123 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 446462010124 Hemerythrin-like domain; Region: Hr-like; cd12108 446462010125 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 446462010126 SpoOM protein; Region: Spo0M; pfam07070 446462010127 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446462010128 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446462010129 DNA binding residues [nucleotide binding] 446462010130 DNA-sulfur modification-associated; Region: DndB; pfam14072 446462010131 DGQHR domain; Region: DGQHR; TIGR03187 446462010132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462010133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462010134 active site 446462010135 ATP binding site [chemical binding]; other site 446462010136 substrate binding site [chemical binding]; other site 446462010137 activation loop (A-loop); other site 446462010138 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 446462010139 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446462010140 NAD binding site [chemical binding]; other site 446462010141 catalytic Zn binding site [ion binding]; other site 446462010142 substrate binding site [chemical binding]; other site 446462010143 structural Zn binding site [ion binding]; other site 446462010144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446462010145 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462010146 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462010147 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462010148 putative sugar binding sites [chemical binding]; other site 446462010149 Q-X-W motif; other site 446462010150 MFS/sugar transport protein; Region: MFS_2; pfam13347 446462010151 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 446462010152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462010153 catalytic residue [active] 446462010154 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462010155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462010156 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446462010157 dimer interface [polypeptide binding]; other site 446462010158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462010159 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 446462010160 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 446462010161 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 446462010162 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446462010163 alpha-galactosidase; Region: PLN02808; cl17638 446462010164 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462010165 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462010166 putative sugar binding sites [chemical binding]; other site 446462010167 Q-X-W motif; other site 446462010168 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462010169 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446462010170 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462010171 calcium binding site 2 [ion binding]; other site 446462010172 active site 446462010173 catalytic triad [active] 446462010174 calcium binding site 1 [ion binding]; other site 446462010175 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462010176 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446462010177 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446462010178 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446462010179 TPP-binding site; other site 446462010180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446462010181 PYR/PP interface [polypeptide binding]; other site 446462010182 dimer interface [polypeptide binding]; other site 446462010183 TPP binding site [chemical binding]; other site 446462010184 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446462010185 substrate binding pocket [chemical binding]; other site 446462010186 substrate-Mg2+ binding site; other site 446462010187 aspartate-rich region 1; other site 446462010188 Predicted transcriptional regulator [Transcription]; Region: COG1959 446462010189 Transcriptional regulator; Region: Rrf2; cl17282 446462010190 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 446462010191 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 446462010192 heme-binding site [chemical binding]; other site 446462010193 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 446462010194 FAD binding pocket [chemical binding]; other site 446462010195 FAD binding motif [chemical binding]; other site 446462010196 phosphate binding motif [ion binding]; other site 446462010197 beta-alpha-beta structure motif; other site 446462010198 NAD binding pocket [chemical binding]; other site 446462010199 Heme binding pocket [chemical binding]; other site 446462010200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462010201 dimerization interface [polypeptide binding]; other site 446462010202 putative DNA binding site [nucleotide binding]; other site 446462010203 putative Zn2+ binding site [ion binding]; other site 446462010204 phytoene desaturase; Region: crtI_fam; TIGR02734 446462010205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462010206 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446462010207 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446462010208 substrate binding pocket [chemical binding]; other site 446462010209 chain length determination region; other site 446462010210 substrate-Mg2+ binding site; other site 446462010211 catalytic residues [active] 446462010212 aspartate-rich region 1; other site 446462010213 active site lid residues [active] 446462010214 aspartate-rich region 2; other site 446462010215 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 446462010216 active site lid residues [active] 446462010217 substrate binding pocket [chemical binding]; other site 446462010218 catalytic residues [active] 446462010219 substrate-Mg2+ binding site; other site 446462010220 aspartate-rich region 1; other site 446462010221 aspartate-rich region 2; other site 446462010222 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 446462010223 iron-sulfur cluster [ion binding]; other site 446462010224 [2Fe-2S] cluster binding site [ion binding]; other site 446462010225 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 446462010226 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446462010227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462010228 S-adenosylmethionine binding site [chemical binding]; other site 446462010229 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 446462010230 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 446462010231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010233 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446462010234 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462010235 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462010236 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462010237 active site 446462010238 catalytic tetrad [active] 446462010239 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462010240 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462010241 Cna protein B-type domain; Region: Cna_B; pfam05738 446462010242 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462010243 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462010244 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446462010245 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 446462010246 putative substrate binding pocket [chemical binding]; other site 446462010247 trimer interface [polypeptide binding]; other site 446462010248 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446462010249 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446462010250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462010251 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462010252 acyl-activating enzyme (AAE) consensus motif; other site 446462010253 AMP binding site [chemical binding]; other site 446462010254 active site 446462010255 CoA binding site [chemical binding]; other site 446462010256 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446462010257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462010258 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446462010259 S-adenosylmethionine binding site [chemical binding]; other site 446462010260 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462010261 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462010262 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462010263 acyl-activating enzyme (AAE) consensus motif; other site 446462010264 acyl-activating enzyme (AAE) consensus motif; other site 446462010265 AMP binding site [chemical binding]; other site 446462010266 active site 446462010267 CoA binding site [chemical binding]; other site 446462010268 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462010269 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 446462010270 UbiA prenyltransferase family; Region: UbiA; pfam01040 446462010271 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 446462010272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462010273 S-adenosylmethionine binding site [chemical binding]; other site 446462010274 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446462010275 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 446462010276 inhibitor-cofactor binding pocket; inhibition site 446462010277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462010278 catalytic residue [active] 446462010279 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446462010280 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 446462010281 inhibitor-cofactor binding pocket; inhibition site 446462010282 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462010283 catalytic residue [active] 446462010284 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462010285 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446462010286 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446462010287 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 446462010288 metal binding site [ion binding]; metal-binding site 446462010289 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 446462010290 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462010291 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462010292 EF-hand domain pair; Region: EF_hand_5; pfam13499 446462010293 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 446462010294 EF-hand domain pair; Region: EF_hand_5; pfam13499 446462010295 Ca2+ binding site [ion binding]; other site 446462010296 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 446462010297 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446462010298 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446462010299 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 446462010300 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462010301 putative NAD(P) binding site [chemical binding]; other site 446462010302 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462010303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010304 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446462010305 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446462010306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462010307 catalytic residue [active] 446462010308 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446462010309 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446462010310 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462010311 substrate binding site [chemical binding]; other site 446462010312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462010313 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462010314 PAS domain; Region: PAS_9; pfam13426 446462010315 putative active site [active] 446462010316 heme pocket [chemical binding]; other site 446462010317 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462010318 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462010319 anti sigma factor interaction site; other site 446462010320 regulatory phosphorylation site [posttranslational modification]; other site 446462010321 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 446462010322 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462010323 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446462010324 active site 446462010325 metal binding site [ion binding]; metal-binding site 446462010326 Bacterial transcriptional activator domain; Region: BTAD; smart01043 446462010327 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 446462010328 YcaO-like family; Region: YcaO; pfam02624 446462010329 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 446462010330 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446462010331 dimer interface [polypeptide binding]; other site 446462010332 SpaB C-terminal domain; Region: SpaB_C; pfam14028 446462010333 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446462010334 FMN binding site [chemical binding]; other site 446462010335 dimer interface [polypeptide binding]; other site 446462010336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010337 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 446462010338 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446462010339 active site 446462010340 catalytic triad [active] 446462010341 oxyanion hole [active] 446462010342 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462010343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462010344 active site 446462010345 phosphorylation site [posttranslational modification] 446462010346 intermolecular recognition site; other site 446462010347 dimerization interface [polypeptide binding]; other site 446462010348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462010349 DNA binding site [nucleotide binding] 446462010350 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 446462010351 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462010352 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462010353 DNA binding site [nucleotide binding] 446462010354 active site 446462010355 Int/Topo IB signature motif; other site 446462010356 Short repeats of unknown function; Region: ALF; pfam03752 446462010357 Short repeats of unknown function; Region: ALF; pfam03752 446462010358 Short repeats of unknown function; Region: ALF; pfam03752 446462010359 Short repeats of unknown function; Region: ALF; pfam03752 446462010360 Short repeats of unknown function; Region: ALF; pfam03752 446462010361 Short repeats of unknown function; Region: ALF; pfam03752 446462010362 Short repeats of unknown function; Region: ALF; pfam03752 446462010363 Short repeats of unknown function; Region: ALF; pfam03752 446462010364 Short repeats of unknown function; Region: ALF; pfam03752 446462010365 Short repeats of unknown function; Region: ALF; pfam03752 446462010366 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 446462010367 protein-splicing catalytic site; other site 446462010368 thioester formation/cholesterol transfer; other site 446462010369 Pretoxin HINT domain; Region: PT-HINT; pfam07591 446462010370 Trypsin; Region: Trypsin; pfam00089 446462010371 active site 446462010372 substrate binding sites [chemical binding]; other site 446462010373 acyltransferase PapA5; Provisional; Region: PRK09294 446462010374 oxidoreductase; Provisional; Region: PRK06196 446462010375 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446462010376 putative NAD(P) binding site [chemical binding]; other site 446462010377 active site 446462010378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010380 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446462010381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446462010382 Condensation domain; Region: Condensation; pfam00668 446462010383 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462010384 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462010385 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462010386 acyl-activating enzyme (AAE) consensus motif; other site 446462010387 AMP binding site [chemical binding]; other site 446462010388 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462010389 Thioesterase domain; Region: Thioesterase; pfam00975 446462010390 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462010391 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462010392 acyl-activating enzyme (AAE) consensus motif; other site 446462010393 AMP binding site [chemical binding]; other site 446462010394 active site 446462010395 CoA binding site [chemical binding]; other site 446462010396 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462010397 Condensation domain; Region: Condensation; pfam00668 446462010398 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462010399 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462010400 AMP-binding enzyme; Region: AMP-binding; pfam00501 446462010401 acyl-activating enzyme (AAE) consensus motif; other site 446462010402 AMP binding site [chemical binding]; other site 446462010403 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462010404 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462010405 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462010406 active site 446462010407 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 446462010408 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462010409 putative NADP binding site [chemical binding]; other site 446462010410 active site 446462010411 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462010412 Thioesterase domain; Region: Thioesterase; pfam00975 446462010413 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 446462010414 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 446462010415 substrate binding pocket [chemical binding]; other site 446462010416 active site 446462010417 iron coordination sites [ion binding]; other site 446462010418 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462010419 Cytochrome P450; Region: p450; cl12078 446462010420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462010421 active site 446462010422 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462010423 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462010424 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462010425 active site 446462010426 TDP-binding site; other site 446462010427 acceptor substrate-binding pocket; other site 446462010428 homodimer interface [polypeptide binding]; other site 446462010429 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446462010430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010431 NAD(P) binding site [chemical binding]; other site 446462010432 active site 446462010433 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 446462010434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462010435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462010436 dimerization interface [polypeptide binding]; other site 446462010437 Cupin domain; Region: Cupin_2; pfam07883 446462010438 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446462010439 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462010440 putative NAD(P) binding site [chemical binding]; other site 446462010441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462010442 sequence-specific DNA binding site [nucleotide binding]; other site 446462010443 salt bridge; other site 446462010444 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446462010445 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446462010446 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 446462010447 active site 446462010448 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446462010449 FecCD transport family; Region: FecCD; pfam01032 446462010450 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446462010451 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462010452 intersubunit interface [polypeptide binding]; other site 446462010453 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446462010454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462010455 S-adenosylmethionine binding site [chemical binding]; other site 446462010456 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462010457 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462010458 Walker A/P-loop; other site 446462010459 ATP binding site [chemical binding]; other site 446462010460 Q-loop/lid; other site 446462010461 ABC transporter signature motif; other site 446462010462 Walker B; other site 446462010463 D-loop; other site 446462010464 H-loop/switch region; other site 446462010465 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462010466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462010467 dimer interface [polypeptide binding]; other site 446462010468 putative PBP binding regions; other site 446462010469 ABC-ATPase subunit interface; other site 446462010470 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446462010471 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462010472 intersubunit interface [polypeptide binding]; other site 446462010473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 446462010474 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 446462010475 Methyltransferase domain; Region: Methyltransf_18; pfam12847 446462010476 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 446462010477 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462010478 catalytic triad [active] 446462010479 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 446462010480 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 446462010481 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446462010482 active site 446462010483 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446462010484 active site 446462010485 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462010486 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462010487 putative sugar binding sites [chemical binding]; other site 446462010488 Q-X-W motif; other site 446462010489 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 446462010490 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 446462010491 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446462010492 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 446462010493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462010494 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462010495 active site 446462010496 catalytic tetrad [active] 446462010497 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 446462010498 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 446462010499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462010500 S-adenosylmethionine binding site [chemical binding]; other site 446462010501 RibD C-terminal domain; Region: RibD_C; cl17279 446462010502 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446462010503 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 446462010504 putative hydrophobic ligand binding site [chemical binding]; other site 446462010505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462010506 dimerization interface [polypeptide binding]; other site 446462010507 putative DNA binding site [nucleotide binding]; other site 446462010508 putative Zn2+ binding site [ion binding]; other site 446462010509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462010510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462010511 non-specific DNA binding site [nucleotide binding]; other site 446462010512 salt bridge; other site 446462010513 sequence-specific DNA binding site [nucleotide binding]; other site 446462010514 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462010515 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462010516 putative sugar binding sites [chemical binding]; other site 446462010517 Q-X-W motif; other site 446462010518 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446462010519 active site 446462010520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462010521 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462010522 active site 446462010523 catalytic tetrad [active] 446462010524 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462010525 anti sigma factor interaction site; other site 446462010526 regulatory phosphorylation site [posttranslational modification]; other site 446462010527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462010528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462010529 DNA binding residues [nucleotide binding] 446462010530 dimerization interface [polypeptide binding]; other site 446462010531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462010532 putative substrate translocation pore; other site 446462010533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462010534 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462010535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010536 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 446462010537 PAS fold; Region: PAS_4; pfam08448 446462010538 GAF domain; Region: GAF_2; pfam13185 446462010539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462010540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462010541 dimer interface [polypeptide binding]; other site 446462010542 phosphorylation site [posttranslational modification] 446462010543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462010544 ATP binding site [chemical binding]; other site 446462010545 Mg2+ binding site [ion binding]; other site 446462010546 G-X-G motif; other site 446462010547 Response regulator receiver domain; Region: Response_reg; pfam00072 446462010548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462010549 active site 446462010550 phosphorylation site [posttranslational modification] 446462010551 intermolecular recognition site; other site 446462010552 dimerization interface [polypeptide binding]; other site 446462010553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462010554 PAS domain; Region: PAS_9; pfam13426 446462010555 putative active site [active] 446462010556 heme pocket [chemical binding]; other site 446462010557 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462010558 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462010559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462010560 ATP binding site [chemical binding]; other site 446462010561 Mg2+ binding site [ion binding]; other site 446462010562 G-X-G motif; other site 446462010563 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462010564 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462010565 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462010566 ligand binding site [chemical binding]; other site 446462010567 flexible hinge region; other site 446462010568 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446462010569 Amb_all domain; Region: Amb_all; smart00656 446462010570 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 446462010571 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462010572 Cellulose binding domain; Region: CBM_2; pfam00553 446462010573 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446462010574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462010575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462010576 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446462010577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462010578 sequence-specific DNA binding site [nucleotide binding]; other site 446462010579 salt bridge; other site 446462010580 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446462010581 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 446462010582 putative NAD(P) binding site [chemical binding]; other site 446462010583 putative substrate binding site [chemical binding]; other site 446462010584 catalytic Zn binding site [ion binding]; other site 446462010585 structural Zn binding site [ion binding]; other site 446462010586 dimer interface [polypeptide binding]; other site 446462010587 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446462010588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462010589 non-specific DNA binding site [nucleotide binding]; other site 446462010590 salt bridge; other site 446462010591 sequence-specific DNA binding site [nucleotide binding]; other site 446462010592 PQQ-like domain; Region: PQQ_2; pfam13360 446462010593 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462010594 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462010595 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446462010596 LexA repressor; Validated; Region: PRK00215 446462010597 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 446462010598 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 446462010599 Catalytic site [active] 446462010600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010601 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010602 short chain dehydrogenase; Provisional; Region: PRK06500 446462010603 classical (c) SDRs; Region: SDR_c; cd05233 446462010604 NAD(P) binding site [chemical binding]; other site 446462010605 active site 446462010606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010607 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446462010608 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446462010609 dimerization interface [polypeptide binding]; other site 446462010610 active site 446462010611 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462010612 MarR family; Region: MarR; pfam01047 446462010613 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446462010614 catalytic motif [active] 446462010615 Zn binding site [ion binding]; other site 446462010616 RibD C-terminal domain; Region: RibD_C; pfam01872 446462010617 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 446462010618 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 446462010619 metal binding site [ion binding]; metal-binding site 446462010620 dimer interface [polypeptide binding]; other site 446462010621 HEAT repeats; Region: HEAT_2; pfam13646 446462010622 oxidoreductase; Provisional; Region: PRK06128 446462010623 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 446462010624 NAD binding site [chemical binding]; other site 446462010625 metal binding site [ion binding]; metal-binding site 446462010626 active site 446462010627 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; pfam01670 446462010628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010629 active site 446462010630 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 446462010631 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462010632 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 446462010633 putative dimer interface [polypeptide binding]; other site 446462010634 N-terminal domain interface [polypeptide binding]; other site 446462010635 putative substrate binding pocket (H-site) [chemical binding]; other site 446462010636 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462010637 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462010638 DNA binding residues [nucleotide binding] 446462010639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010640 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462010641 NAD(P) binding site [chemical binding]; other site 446462010642 active site 446462010643 RDD family; Region: RDD; pfam06271 446462010644 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462010645 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462010646 AAA domain; Region: AAA_17; pfam13207 446462010647 AAA domain; Region: AAA_18; pfam13238 446462010648 SEFIR domain; Region: SEFIR; pfam08357 446462010649 Histidine kinase; Region: HisKA_3; pfam07730 446462010650 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462010651 Mg2+ binding site [ion binding]; other site 446462010652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462010653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462010654 active site 446462010655 phosphorylation site [posttranslational modification] 446462010656 intermolecular recognition site; other site 446462010657 dimerization interface [polypeptide binding]; other site 446462010658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462010659 DNA binding residues [nucleotide binding] 446462010660 dimerization interface [polypeptide binding]; other site 446462010661 Trehalase; Region: Trehalase; cl17346 446462010662 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 446462010663 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446462010664 hypothetical protein; Provisional; Region: PRK07236 446462010665 hypothetical protein; Provisional; Region: PRK07588 446462010666 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010668 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446462010669 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446462010670 Protein of unknown function (DUF993); Region: DUF993; pfam06187 446462010671 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462010672 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462010673 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 446462010674 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 446462010675 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462010676 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446462010677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462010678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462010679 DNA binding site [nucleotide binding] 446462010680 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 446462010681 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446462010682 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 446462010683 homodimer interface [polypeptide binding]; other site 446462010684 NADP binding site [chemical binding]; other site 446462010685 substrate binding site [chemical binding]; other site 446462010686 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 446462010687 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446462010688 homodimer interface [polypeptide binding]; other site 446462010689 substrate-cofactor binding pocket; other site 446462010690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462010691 catalytic residue [active] 446462010692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010693 NAD(P) binding site [chemical binding]; other site 446462010694 active site 446462010695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010696 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462010697 NAD(P) binding site [chemical binding]; other site 446462010698 active site 446462010699 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462010700 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462010701 active site 446462010702 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462010703 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462010704 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462010705 active site 446462010706 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462010707 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462010708 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462010709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010710 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446462010711 Enoylreductase; Region: PKS_ER; smart00829 446462010712 NAD(P) binding site [chemical binding]; other site 446462010713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010714 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462010715 NAD(P) binding site [chemical binding]; other site 446462010716 active site 446462010717 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462010718 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462010719 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462010720 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462010721 active site 446462010722 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462010723 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462010724 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462010725 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462010726 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462010727 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462010728 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462010729 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446462010730 Enoylreductase; Region: PKS_ER; smart00829 446462010731 NAD(P) binding site [chemical binding]; other site 446462010732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010733 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462010734 NAD(P) binding site [chemical binding]; other site 446462010735 active site 446462010736 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462010737 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446462010738 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462010739 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462010740 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462010741 active site 446462010742 ATP binding site [chemical binding]; other site 446462010743 substrate binding site [chemical binding]; other site 446462010744 activation loop (A-loop); other site 446462010745 Septum formation; Region: Septum_form; pfam13845 446462010746 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 446462010747 Bacterial Ig-like domain; Region: Big_5; pfam13205 446462010748 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 446462010749 Bacterial Ig-like domain; Region: Big_5; pfam13205 446462010750 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 446462010751 Bacterial Ig-like domain; Region: Big_5; pfam13205 446462010752 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 446462010753 substrate binding pocket [chemical binding]; other site 446462010754 catalytic residues [active] 446462010755 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462010756 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462010757 putative sugar binding sites [chemical binding]; other site 446462010758 Q-X-W motif; other site 446462010759 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462010760 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462010761 acyl-activating enzyme (AAE) consensus motif; other site 446462010762 acyl-activating enzyme (AAE) consensus motif; other site 446462010763 active site 446462010764 AMP binding site [chemical binding]; other site 446462010765 CoA binding site [chemical binding]; other site 446462010766 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 446462010767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462010768 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 446462010769 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 446462010770 active site 446462010771 substrate binding site [chemical binding]; other site 446462010772 FMN binding site [chemical binding]; other site 446462010773 putative catalytic residues [active] 446462010774 Cytochrome P450; Region: p450; cl12078 446462010775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462010776 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 446462010777 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446462010778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462010779 dimerization interface [polypeptide binding]; other site 446462010780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462010781 dimer interface [polypeptide binding]; other site 446462010782 phosphorylation site [posttranslational modification] 446462010783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462010784 Mg2+ binding site [ion binding]; other site 446462010785 G-X-G motif; other site 446462010786 Tetratrico peptide repeat; Region: TPR_5; pfam12688 446462010787 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446462010788 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 446462010789 active site pocket [active] 446462010790 von Willebrand factor type A domain; Region: VWA_2; pfam13519 446462010791 Calx-beta domain; Region: Calx-beta; pfam03160 446462010792 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462010793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462010794 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462010795 Walker A/P-loop; other site 446462010796 ATP binding site [chemical binding]; other site 446462010797 Q-loop/lid; other site 446462010798 ABC transporter signature motif; other site 446462010799 Walker B; other site 446462010800 D-loop; other site 446462010801 H-loop/switch region; other site 446462010802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462010803 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446462010804 Walker A/P-loop; other site 446462010805 ATP binding site [chemical binding]; other site 446462010806 Q-loop/lid; other site 446462010807 ABC transporter signature motif; other site 446462010808 Walker B; other site 446462010809 D-loop; other site 446462010810 H-loop/switch region; other site 446462010811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010812 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446462010813 FtsX-like permease family; Region: FtsX; pfam02687 446462010814 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462010815 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462010816 Walker A/P-loop; other site 446462010817 ATP binding site [chemical binding]; other site 446462010818 Q-loop/lid; other site 446462010819 ABC transporter signature motif; other site 446462010820 Walker B; other site 446462010821 D-loop; other site 446462010822 H-loop/switch region; other site 446462010823 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462010824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462010825 active site 446462010826 phosphorylation site [posttranslational modification] 446462010827 intermolecular recognition site; other site 446462010828 dimerization interface [polypeptide binding]; other site 446462010829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462010830 DNA binding residues [nucleotide binding] 446462010831 dimerization interface [polypeptide binding]; other site 446462010832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462010833 Histidine kinase; Region: HisKA_3; pfam07730 446462010834 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462010835 SnoaL-like domain; Region: SnoaL_2; pfam12680 446462010836 Predicted transcriptional regulator [Transcription]; Region: COG2378 446462010837 HTH domain; Region: HTH_11; pfam08279 446462010838 WYL domain; Region: WYL; pfam13280 446462010839 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446462010840 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446462010841 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446462010842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462010845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462010846 dimerization interface [polypeptide binding]; other site 446462010847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462010848 dimer interface [polypeptide binding]; other site 446462010849 phosphorylation site [posttranslational modification] 446462010850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462010851 ATP binding site [chemical binding]; other site 446462010852 Mg2+ binding site [ion binding]; other site 446462010853 G-X-G motif; other site 446462010854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462010855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462010856 active site 446462010857 phosphorylation site [posttranslational modification] 446462010858 intermolecular recognition site; other site 446462010859 dimerization interface [polypeptide binding]; other site 446462010860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462010861 DNA binding site [nucleotide binding] 446462010862 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446462010863 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462010864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462010865 Walker A/P-loop; other site 446462010866 ATP binding site [chemical binding]; other site 446462010867 Q-loop/lid; other site 446462010868 ABC transporter signature motif; other site 446462010869 Walker B; other site 446462010870 D-loop; other site 446462010871 H-loop/switch region; other site 446462010872 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446462010873 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446462010874 FtsX-like permease family; Region: FtsX; pfam02687 446462010875 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446462010876 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462010877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462010878 catalytic residue [active] 446462010879 choline dehydrogenase; Validated; Region: PRK02106 446462010880 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446462010881 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446462010882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462010883 S-adenosylmethionine binding site [chemical binding]; other site 446462010884 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446462010885 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 446462010886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010887 NAD(P) binding site [chemical binding]; other site 446462010888 active site 446462010889 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446462010890 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446462010891 active site 446462010892 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462010893 3-oxoacyl-[acyl-carrier-protein] synthase; Region: PLN02836 446462010894 active site 446462010895 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462010896 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462010897 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 446462010898 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462010899 putative NADP binding site [chemical binding]; other site 446462010900 active site 446462010901 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462010902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462010903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462010904 active site 446462010905 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462010906 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462010907 active site 446462010908 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446462010909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462010910 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462010911 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446462010912 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462010913 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 446462010914 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 446462010915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462010916 active site 446462010917 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462010918 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462010919 active site 446462010920 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446462010921 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462010922 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 446462010923 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462010924 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462010925 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462010926 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446462010927 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462010928 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 446462010929 ABC1 family; Region: ABC1; cl17513 446462010930 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 446462010931 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446462010932 short chain dehydrogenase; Validated; Region: PRK06182 446462010933 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 446462010934 NADP binding site [chemical binding]; other site 446462010935 active site 446462010936 steroid binding site; other site 446462010937 choline dehydrogenase; Validated; Region: PRK02106 446462010938 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446462010939 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 446462010940 Cytochrome P450; Region: p450; cl12078 446462010941 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462010942 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446462010943 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462010944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462010945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010947 WHG domain; Region: WHG; pfam13305 446462010948 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 446462010949 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462010950 putative NAD(P) binding site [chemical binding]; other site 446462010951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462010952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462010953 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446462010954 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462010955 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462010956 Family description; Region: VCBS; pfam13517 446462010957 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 446462010958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462010959 NAD(P) binding site [chemical binding]; other site 446462010960 active site 446462010961 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 446462010962 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462010963 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462010964 acyl-activating enzyme (AAE) consensus motif; other site 446462010965 AMP binding site [chemical binding]; other site 446462010966 active site 446462010967 CoA binding site [chemical binding]; other site 446462010968 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 446462010969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462010970 substrate binding site [chemical binding]; other site 446462010971 oxyanion hole (OAH) forming residues; other site 446462010972 trimer interface [polypeptide binding]; other site 446462010973 Family description; Region: VCBS; pfam13517 446462010974 Family description; Region: VCBS; pfam13517 446462010975 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 446462010976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462010977 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462010978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462010979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 446462010980 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 446462010981 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446462010982 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446462010983 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 446462010984 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446462010985 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 446462010986 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446462010987 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 446462010988 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446462010989 catalytic loop [active] 446462010990 iron binding site [ion binding]; other site 446462010991 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 446462010992 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 446462010993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462010994 ATP binding site [chemical binding]; other site 446462010995 putative Mg++ binding site [ion binding]; other site 446462010996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462010997 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446462010998 nucleotide binding region [chemical binding]; other site 446462010999 ATP-binding site [chemical binding]; other site 446462011000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462011001 ATP binding site [chemical binding]; other site 446462011002 putative Mg++ binding site [ion binding]; other site 446462011003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462011004 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 446462011005 nucleotide binding region [chemical binding]; other site 446462011006 ATP-binding site [chemical binding]; other site 446462011007 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 446462011008 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462011009 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462011010 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462011011 ligand binding site [chemical binding]; other site 446462011012 dimerization interface [polypeptide binding]; other site 446462011013 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462011014 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446462011015 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 446462011016 putative active site pocket [active] 446462011017 putative metal binding site [ion binding]; other site 446462011018 Cellulose binding domain; Region: CBM_2; pfam00553 446462011019 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446462011020 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 446462011021 SnoaL-like domain; Region: SnoaL_3; pfam13474 446462011022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462011023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462011024 dimerization interface [polypeptide binding]; other site 446462011025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462011026 dimer interface [polypeptide binding]; other site 446462011027 phosphorylation site [posttranslational modification] 446462011028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462011029 ATP binding site [chemical binding]; other site 446462011030 G-X-G motif; other site 446462011031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462011032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462011033 active site 446462011034 phosphorylation site [posttranslational modification] 446462011035 intermolecular recognition site; other site 446462011036 dimerization interface [polypeptide binding]; other site 446462011037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462011038 DNA binding site [nucleotide binding] 446462011039 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 446462011040 NAD binding site [chemical binding]; other site 446462011041 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462011042 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446462011043 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446462011044 metal ion-dependent adhesion site (MIDAS); other site 446462011045 Pirin-related protein [General function prediction only]; Region: COG1741 446462011046 Pirin; Region: Pirin; pfam02678 446462011047 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446462011048 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 446462011049 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462011050 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462011051 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462011052 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462011053 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462011054 putative sugar binding sites [chemical binding]; other site 446462011055 Q-X-W motif; other site 446462011056 Ricin-type beta-trefoil; Region: RICIN; smart00458 446462011057 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462011058 putative sugar binding sites [chemical binding]; other site 446462011059 Q-X-W motif; other site 446462011060 Ricin-type beta-trefoil; Region: RICIN; smart00458 446462011061 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462011062 putative sugar binding sites [chemical binding]; other site 446462011063 Q-X-W motif; other site 446462011064 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462011065 Cellulose binding domain; Region: CBM_2; pfam00553 446462011066 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 446462011067 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 446462011068 tellurite resistance protein terB; Region: terB; cd07176 446462011069 putative metal binding site [ion binding]; other site 446462011070 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462011071 active site 446462011072 catalytic triad [active] 446462011073 oxyanion hole [active] 446462011074 methionine sulfoxide reductase A; Provisional; Region: PRK14054 446462011075 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 446462011076 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 446462011077 active site 446462011078 citrylCoA binding site [chemical binding]; other site 446462011079 oxalacetate binding site [chemical binding]; other site 446462011080 coenzyme A binding site [chemical binding]; other site 446462011081 catalytic triad [active] 446462011082 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446462011083 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446462011084 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 446462011085 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 446462011086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 446462011087 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446462011088 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462011089 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462011090 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 446462011091 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 446462011092 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446462011093 ligand binding site [chemical binding]; other site 446462011094 NAD binding site [chemical binding]; other site 446462011095 dimerization interface [polypeptide binding]; other site 446462011096 catalytic site [active] 446462011097 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 446462011098 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446462011099 AroM protein; Region: AroM; cl17601 446462011100 OPT oligopeptide transporter protein; Region: OPT; cl14607 446462011101 OPT oligopeptide transporter protein; Region: OPT; cl14607 446462011102 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462011103 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446462011104 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462011105 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 446462011106 active site pocket [active] 446462011107 oxyanion hole [active] 446462011108 catalytic triad [active] 446462011109 active site nucleophile [active] 446462011110 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462011111 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462011112 active site 446462011113 ATP binding site [chemical binding]; other site 446462011114 substrate binding site [chemical binding]; other site 446462011115 activation loop (A-loop); other site 446462011116 Cellulose binding domain; Region: CBM_2; pfam00553 446462011117 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462011118 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462011119 putative sugar binding sites [chemical binding]; other site 446462011120 Q-X-W motif; other site 446462011121 Pectate lyase; Region: Pectate_lyase; pfam03211 446462011122 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446462011123 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462011124 putative NAD(P) binding site [chemical binding]; other site 446462011125 MarR family; Region: MarR; pfam01047 446462011126 MarR family; Region: MarR_2; cl17246 446462011127 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 446462011128 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446462011129 active site 446462011130 AAA domain; Region: AAA_22; pfam13401 446462011131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462011132 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462011133 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 446462011134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462011135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462011136 dimerization interface [polypeptide binding]; other site 446462011137 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462011138 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462011139 dimer interface [polypeptide binding]; other site 446462011140 putative CheW interface [polypeptide binding]; other site 446462011141 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 446462011142 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 446462011143 putative active site [active] 446462011144 catalytic triad [active] 446462011145 putative dimer interface [polypeptide binding]; other site 446462011146 short chain dehydrogenase; Provisional; Region: PRK05854 446462011147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011148 NAD(P) binding site [chemical binding]; other site 446462011149 active site 446462011150 Helix-turn-helix domain; Region: HTH_31; pfam13560 446462011151 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462011152 sequence-specific DNA binding site [nucleotide binding]; other site 446462011153 salt bridge; other site 446462011154 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446462011155 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462011156 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446462011157 catalytic site [active] 446462011158 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446462011159 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462011160 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462011161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462011162 dimer interface [polypeptide binding]; other site 446462011163 putative CheW interface [polypeptide binding]; other site 446462011164 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446462011165 metal binding site 2 [ion binding]; metal-binding site 446462011166 putative DNA binding helix; other site 446462011167 metal binding site 1 [ion binding]; metal-binding site 446462011168 dimer interface [polypeptide binding]; other site 446462011169 structural Zn2+ binding site [ion binding]; other site 446462011170 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 446462011171 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 446462011172 dimer interface [polypeptide binding]; other site 446462011173 active site 446462011174 heme binding site [chemical binding]; other site 446462011175 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 446462011176 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 446462011177 active site 446462011178 catalytic triad [active] 446462011179 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 446462011180 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 446462011181 catalytic triad [active] 446462011182 putative active site [active] 446462011183 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462011184 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462011185 conserved repeat domain; Region: B_ant_repeat; TIGR01451 446462011186 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462011187 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462011188 putative sugar binding sites [chemical binding]; other site 446462011189 Q-X-W motif; other site 446462011190 putative pectinesterase; Region: PLN02432; cl01911 446462011191 Pectinesterase; Region: Pectinesterase; pfam01095 446462011192 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462011193 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462011194 putative sugar binding sites [chemical binding]; other site 446462011195 Q-X-W motif; other site 446462011196 Amb_all domain; Region: Amb_all; smart00656 446462011197 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 446462011198 active site 446462011199 SAM binding site [chemical binding]; other site 446462011200 homodimer interface [polypeptide binding]; other site 446462011201 hypothetical protein; Provisional; Region: PRK08244 446462011202 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462011203 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446462011204 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462011205 inhibitor-cofactor binding pocket; inhibition site 446462011206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462011207 catalytic residue [active] 446462011208 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 446462011209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462011210 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446462011211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462011212 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446462011213 Cupin domain; Region: Cupin_2; pfam07883 446462011214 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 446462011215 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462011216 active site 446462011217 nucleotide binding site [chemical binding]; other site 446462011218 HIGH motif; other site 446462011219 KMSKS motif; other site 446462011220 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 446462011221 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 446462011222 EamA-like transporter family; Region: EamA; pfam00892 446462011223 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446462011224 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462011225 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 446462011226 active site residue [active] 446462011227 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462011228 AMP-binding enzyme; Region: AMP-binding; pfam00501 446462011229 acyl-activating enzyme (AAE) consensus motif; other site 446462011230 active site 446462011231 AMP binding site [chemical binding]; other site 446462011232 CoA binding site [chemical binding]; other site 446462011233 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446462011234 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462011235 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462011236 acyl-activating enzyme (AAE) consensus motif; other site 446462011237 AMP binding site [chemical binding]; other site 446462011238 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446462011239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462011240 Coenzyme A binding pocket [chemical binding]; other site 446462011241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462011242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462011243 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 446462011244 putative substrate binding pocket [chemical binding]; other site 446462011245 putative dimerization interface [polypeptide binding]; other site 446462011246 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 446462011247 active site 446462011248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011249 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462011250 active site 446462011251 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 446462011252 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462011253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462011254 dimerization interface [polypeptide binding]; other site 446462011255 putative DNA binding site [nucleotide binding]; other site 446462011256 putative Zn2+ binding site [ion binding]; other site 446462011257 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446462011258 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446462011259 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446462011260 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462011261 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446462011262 DNA binding residues [nucleotide binding] 446462011263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011264 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 446462011265 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446462011266 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 446462011267 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 446462011268 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462011269 Cytochrome P450; Region: p450; cl12078 446462011270 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446462011271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462011272 ATP binding site [chemical binding]; other site 446462011273 putative Mg++ binding site [ion binding]; other site 446462011274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462011275 nucleotide binding region [chemical binding]; other site 446462011276 ATP-binding site [chemical binding]; other site 446462011277 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 446462011278 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446462011279 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462011280 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462011281 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446462011282 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446462011283 carboxyltransferase (CT) interaction site; other site 446462011284 biotinylation site [posttranslational modification]; other site 446462011285 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 446462011286 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446462011287 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462011288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462011289 dimer interface [polypeptide binding]; other site 446462011290 conserved gate region; other site 446462011291 putative PBP binding loops; other site 446462011292 ABC-ATPase subunit interface; other site 446462011293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462011294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462011295 ABC-ATPase subunit interface; other site 446462011296 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462011297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462011298 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462011299 active site 446462011300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462011301 catalytic tetrad [active] 446462011302 Helix-turn-helix domain; Region: HTH_31; pfam13560 446462011303 salt bridge; other site 446462011304 non-specific DNA binding site [nucleotide binding]; other site 446462011305 sequence-specific DNA binding site [nucleotide binding]; other site 446462011306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462011307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462011308 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462011309 dimerization interface [polypeptide binding]; other site 446462011310 short chain dehydrogenase; Provisional; Region: PRK06180 446462011311 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 446462011312 NADP binding site [chemical binding]; other site 446462011313 active site 446462011314 steroid binding site; other site 446462011315 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 446462011316 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446462011317 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462011318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446462011319 Uncharacterized conserved protein (DUF2039); Region: DUF2039; pfam10217 446462011320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011321 NAD(P) binding site [chemical binding]; other site 446462011322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011323 active site 446462011324 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 446462011325 maltose O-acetyltransferase; Provisional; Region: PRK10092 446462011326 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 446462011327 active site 446462011328 substrate binding site [chemical binding]; other site 446462011329 trimer interface [polypeptide binding]; other site 446462011330 CoA binding site [chemical binding]; other site 446462011331 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 446462011332 active site 446462011333 GIY-YIG motif/motif A; other site 446462011334 catalytic site [active] 446462011335 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446462011336 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462011337 hypothetical protein; Provisional; Region: PRK06849 446462011338 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462011339 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462011340 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446462011341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462011342 S-adenosylmethionine binding site [chemical binding]; other site 446462011343 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 446462011344 active site 446462011345 NAD binding site [chemical binding]; other site 446462011346 metal binding site [ion binding]; metal-binding site 446462011347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462011348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462011349 active site 446462011350 phosphorylation site [posttranslational modification] 446462011351 intermolecular recognition site; other site 446462011352 dimerization interface [polypeptide binding]; other site 446462011353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462011354 DNA binding residues [nucleotide binding] 446462011355 dimerization interface [polypeptide binding]; other site 446462011356 Histidine kinase; Region: HisKA_3; pfam07730 446462011357 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462011358 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462011359 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462011360 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462011361 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462011362 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446462011363 homotrimer interaction site [polypeptide binding]; other site 446462011364 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446462011365 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462011366 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462011367 MarR family; Region: MarR_2; pfam12802 446462011368 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 446462011369 AAA ATPase domain; Region: AAA_16; pfam13191 446462011370 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462011371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462011372 DNA binding residues [nucleotide binding] 446462011373 dimerization interface [polypeptide binding]; other site 446462011374 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 446462011375 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446462011376 putative active site [active] 446462011377 putative FMN binding site [chemical binding]; other site 446462011378 putative substrate binding site [chemical binding]; other site 446462011379 putative catalytic residue [active] 446462011380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462011381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011382 Phosphotransferase enzyme family; Region: APH; pfam01636 446462011383 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462011384 active site 446462011385 substrate binding site [chemical binding]; other site 446462011386 ATP binding site [chemical binding]; other site 446462011387 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446462011388 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 446462011389 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446462011390 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 446462011391 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462011392 dimerization interface [polypeptide binding]; other site 446462011393 putative DNA binding site [nucleotide binding]; other site 446462011394 putative Zn2+ binding site [ion binding]; other site 446462011395 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 446462011396 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446462011397 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462011398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462011399 dimerization interface [polypeptide binding]; other site 446462011400 putative DNA binding site [nucleotide binding]; other site 446462011401 putative Zn2+ binding site [ion binding]; other site 446462011402 Iron permease FTR1 family; Region: FTR1; cl00475 446462011403 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 446462011404 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 446462011405 Imelysin; Region: Peptidase_M75; pfam09375 446462011406 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 446462011407 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446462011408 Penicillinase repressor; Region: Pencillinase_R; cl17580 446462011409 CGNR zinc finger; Region: zf-CGNR; pfam11706 446462011410 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446462011411 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462011412 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462011413 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462011414 Walker A/P-loop; other site 446462011415 ATP binding site [chemical binding]; other site 446462011416 Q-loop/lid; other site 446462011417 ABC transporter signature motif; other site 446462011418 Walker B; other site 446462011419 D-loop; other site 446462011420 H-loop/switch region; other site 446462011421 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446462011422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462011423 ABC-ATPase subunit interface; other site 446462011424 dimer interface [polypeptide binding]; other site 446462011425 putative PBP binding regions; other site 446462011426 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462011427 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462011428 ABC-ATPase subunit interface; other site 446462011429 dimer interface [polypeptide binding]; other site 446462011430 putative PBP binding regions; other site 446462011431 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446462011432 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446462011433 siderophore binding site; other site 446462011434 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 446462011435 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446462011436 ANTAR domain; Region: ANTAR; pfam03861 446462011437 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462011438 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462011439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462011440 catalytic residue [active] 446462011441 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 446462011442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462011443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462011444 DNA binding residues [nucleotide binding] 446462011445 LabA_like proteins; Region: LabA_like; cd06167 446462011446 putative metal binding site [ion binding]; other site 446462011447 Uncharacterized conserved protein [Function unknown]; Region: COG1432 446462011448 Methyltransferase domain; Region: Methyltransf_12; pfam08242 446462011449 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446462011450 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446462011451 active site residue [active] 446462011452 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446462011453 active site residue [active] 446462011454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446462011455 FAD binding domain; Region: FAD_binding_4; pfam01565 446462011456 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462011457 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462011458 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446462011459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462011460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462011461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446462011462 dimerization interface [polypeptide binding]; other site 446462011463 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446462011464 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 446462011465 dimer interface [polypeptide binding]; other site 446462011466 active site 446462011467 non-prolyl cis peptide bond; other site 446462011468 insertion regions; other site 446462011469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462011470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462011471 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 446462011472 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446462011473 conserved cys residue [active] 446462011474 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446462011475 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446462011476 conserved cys residue [active] 446462011477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011479 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462011480 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462011481 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 446462011482 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462011483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462011484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462011485 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462011486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462011487 dimer interface [polypeptide binding]; other site 446462011488 conserved gate region; other site 446462011489 putative PBP binding loops; other site 446462011490 ABC-ATPase subunit interface; other site 446462011491 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446462011492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462011493 Walker A/P-loop; other site 446462011494 ATP binding site [chemical binding]; other site 446462011495 Q-loop/lid; other site 446462011496 ABC transporter signature motif; other site 446462011497 Walker B; other site 446462011498 D-loop; other site 446462011499 H-loop/switch region; other site 446462011500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462011501 Walker A/P-loop; other site 446462011502 ATP binding site [chemical binding]; other site 446462011503 Q-loop/lid; other site 446462011504 ABC transporter signature motif; other site 446462011505 Walker B; other site 446462011506 D-loop; other site 446462011507 H-loop/switch region; other site 446462011508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462011509 Cna protein B-type domain; Region: Cna_B; pfam05738 446462011510 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462011511 Subtilisin inhibitor-like; Region: SSI; cl11594 446462011512 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 446462011513 hydrophobic ligand binding site; other site 446462011514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462011515 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462011516 salt bridge; other site 446462011517 non-specific DNA binding site [nucleotide binding]; other site 446462011518 sequence-specific DNA binding site [nucleotide binding]; other site 446462011519 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462011520 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462011521 putative sugar binding sites [chemical binding]; other site 446462011522 Q-X-W motif; other site 446462011523 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 446462011524 chitosan binding site [chemical binding]; other site 446462011525 catalytic residues [active] 446462011526 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446462011527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462011528 active site 446462011529 phosphorylation site [posttranslational modification] 446462011530 intermolecular recognition site; other site 446462011531 dimerization interface [polypeptide binding]; other site 446462011532 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 446462011533 FAD binding domain; Region: FAD_binding_2; pfam00890 446462011534 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446462011535 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446462011536 AsnC family; Region: AsnC_trans_reg; pfam01037 446462011537 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 446462011538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011539 hypothetical protein; Provisional; Region: PRK07236 446462011540 hypothetical protein; Provisional; Region: PRK07588 446462011541 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446462011542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462011543 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 446462011544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462011545 putative substrate translocation pore; other site 446462011546 MarR family; Region: MarR; pfam01047 446462011547 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462011548 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446462011549 AsnC family; Region: AsnC_trans_reg; pfam01037 446462011550 Uncharacterized conserved protein [Function unknown]; Region: COG1284 446462011551 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 446462011552 Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441 446462011553 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462011554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462011555 active site 446462011556 phosphorylation site [posttranslational modification] 446462011557 intermolecular recognition site; other site 446462011558 dimerization interface [polypeptide binding]; other site 446462011559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462011560 DNA binding site [nucleotide binding] 446462011561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462011562 Mg2+ binding site [ion binding]; other site 446462011563 G-X-G motif; other site 446462011564 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446462011565 active sites [active] 446462011566 tetramer interface [polypeptide binding]; other site 446462011567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462011568 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446462011569 acyl-CoA synthetase; Validated; Region: PRK06188 446462011570 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462011571 acyl-activating enzyme (AAE) consensus motif; other site 446462011572 AMP binding site [chemical binding]; other site 446462011573 active site 446462011574 CoA binding site [chemical binding]; other site 446462011575 Erythronolide synthase docking; Region: Docking; pfam08990 446462011576 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011577 active site 446462011578 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011579 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462011580 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011581 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011582 active site 446462011583 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462011584 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011585 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462011586 NADP binding site [chemical binding]; other site 446462011587 active site 446462011588 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011589 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011590 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011591 active site 446462011592 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462011593 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011594 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462011595 putative NADP binding site [chemical binding]; other site 446462011596 KR domain; Region: KR; pfam08659 446462011597 active site 446462011598 Erythronolide synthase docking; Region: Docking; pfam08990 446462011599 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011600 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011601 active site 446462011602 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011603 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462011604 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462011605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011606 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462011607 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011608 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011609 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011610 active site 446462011611 Acyl transferase domain; Region: Acyl_transf_1; cl08282 446462011612 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011613 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462011614 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011615 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 446462011616 KR domain; Region: KR; pfam08659 446462011617 NADP binding site [chemical binding]; other site 446462011618 active site 446462011619 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011620 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011621 active site 446462011622 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446462011623 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462011624 putative NADP binding site [chemical binding]; other site 446462011625 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462011626 active site 446462011627 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011628 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462011629 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462011630 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462011631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462011632 S-adenosylmethionine binding site [chemical binding]; other site 446462011633 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 446462011634 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 446462011635 FMN binding site [chemical binding]; other site 446462011636 substrate binding site [chemical binding]; other site 446462011637 putative catalytic residue [active] 446462011638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462011639 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462011640 active site 446462011641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011642 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446462011643 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446462011644 acyl-activating enzyme (AAE) consensus motif; other site 446462011645 putative AMP binding site [chemical binding]; other site 446462011646 putative active site [active] 446462011647 putative CoA binding site [chemical binding]; other site 446462011648 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 446462011649 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446462011650 dimer interface [polypeptide binding]; other site 446462011651 active site 446462011652 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 446462011653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462011654 substrate binding site [chemical binding]; other site 446462011655 oxyanion hole (OAH) forming residues; other site 446462011656 trimer interface [polypeptide binding]; other site 446462011657 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462011658 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462011659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462011660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011661 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 446462011662 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 446462011663 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446462011664 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 446462011665 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446462011666 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 446462011667 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 446462011668 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 446462011669 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446462011670 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462011671 DNA binding residues [nucleotide binding] 446462011672 dimer interface [polypeptide binding]; other site 446462011673 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446462011674 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446462011675 substrate binding pocket [chemical binding]; other site 446462011676 chain length determination region; other site 446462011677 substrate-Mg2+ binding site; other site 446462011678 catalytic residues [active] 446462011679 aspartate-rich region 1; other site 446462011680 active site lid residues [active] 446462011681 aspartate-rich region 2; other site 446462011682 UbiA prenyltransferase family; Region: UbiA; pfam01040 446462011683 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 446462011684 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446462011685 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462011686 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 446462011687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462011688 S-adenosylmethionine binding site [chemical binding]; other site 446462011689 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 446462011690 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 446462011691 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462011692 Cytochrome P450; Region: p450; cl12078 446462011693 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 446462011694 squalene/oxidosqualene cyclases; Region: squalene_cyclas; TIGR01787 446462011695 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 446462011696 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462011697 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 446462011698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462011699 catalytic residue [active] 446462011700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462011701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462011702 putative substrate translocation pore; other site 446462011703 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 446462011704 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446462011705 Catalytic site [active] 446462011706 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462011707 intermolecular salt bridges; other site 446462011708 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 446462011709 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446462011710 Helix-turn-helix domain; Region: HTH_18; pfam12833 446462011711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011712 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446462011713 TIGR03086 family protein; Region: TIGR03086 446462011714 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462011715 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011716 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 446462011717 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446462011718 potential catalytic triad [active] 446462011719 conserved cys residue [active] 446462011720 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446462011721 classical (c) SDRs; Region: SDR_c; cd05233 446462011722 NAD(P) binding site [chemical binding]; other site 446462011723 active site 446462011724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462011725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011726 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462011727 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462011728 DNA binding residues [nucleotide binding] 446462011729 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446462011730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462011731 DNA-binding site [nucleotide binding]; DNA binding site 446462011732 FCD domain; Region: FCD; pfam07729 446462011733 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446462011734 substrate binding site [chemical binding]; other site 446462011735 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 446462011736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462011737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011738 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462011739 anti sigma factor interaction site; other site 446462011740 regulatory phosphorylation site [posttranslational modification]; other site 446462011741 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 446462011742 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446462011743 putative ADP-binding pocket [chemical binding]; other site 446462011744 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462011745 active site 446462011746 ATP binding site [chemical binding]; other site 446462011747 substrate binding site [chemical binding]; other site 446462011748 activation loop (A-loop); other site 446462011749 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446462011750 putative DNA binding helix; other site 446462011751 metal binding site 2 [ion binding]; metal-binding site 446462011752 metal binding site 1 [ion binding]; metal-binding site 446462011753 dimer interface [polypeptide binding]; other site 446462011754 structural Zn2+ binding site [ion binding]; other site 446462011755 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 446462011756 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 446462011757 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 446462011758 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 446462011759 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 446462011760 tetramer interface [polypeptide binding]; other site 446462011761 heme binding pocket [chemical binding]; other site 446462011762 NADPH binding site [chemical binding]; other site 446462011763 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446462011764 conserved cys residue [active] 446462011765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 446462011766 MOSC domain; Region: MOSC; pfam03473 446462011767 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 446462011768 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446462011769 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462011770 MarR family; Region: MarR_2; pfam12802 446462011771 Cupin; Region: Cupin_6; pfam12852 446462011772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462011774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011775 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 446462011776 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462011777 putative NAD(P) binding site [chemical binding]; other site 446462011778 Cupin; Region: Cupin_6; pfam12852 446462011779 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462011780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011781 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462011782 NAD(P) binding site [chemical binding]; other site 446462011783 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462011784 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446462011785 Protein phosphatase 2C; Region: PP2C; pfam00481 446462011786 active site 446462011787 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 446462011788 NmrA-like family; Region: NmrA; pfam05368 446462011789 NADP binding site [chemical binding]; other site 446462011790 active site 446462011791 regulatory binding site [polypeptide binding]; other site 446462011792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462011793 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 446462011794 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446462011795 dimerization interface [polypeptide binding]; other site 446462011796 substrate binding pocket [chemical binding]; other site 446462011797 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 446462011798 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462011799 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462011800 NAD(P) binding site [chemical binding]; other site 446462011801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462011802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462011803 active site 446462011804 phosphorylation site [posttranslational modification] 446462011805 intermolecular recognition site; other site 446462011806 dimerization interface [polypeptide binding]; other site 446462011807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462011808 DNA binding residues [nucleotide binding] 446462011809 dimerization interface [polypeptide binding]; other site 446462011810 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462011811 ATP binding site [chemical binding]; other site 446462011812 Mg2+ binding site [ion binding]; other site 446462011813 G-X-G motif; other site 446462011814 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 446462011815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462011816 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446462011817 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462011818 dimer interface [polypeptide binding]; other site 446462011819 putative PBP binding regions; other site 446462011820 ABC-ATPase subunit interface; other site 446462011821 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446462011822 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446462011823 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 446462011824 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446462011825 metal binding site [ion binding]; metal-binding site 446462011826 Erythronolide synthase docking; Region: Docking; pfam08990 446462011827 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462011828 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011829 active site 446462011830 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011831 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462011832 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462011833 putative NADP binding site [chemical binding]; other site 446462011834 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462011835 active site 446462011836 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011837 thioester reductase domain; Region: Thioester-redct; TIGR01746 446462011838 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 446462011839 putative NAD(P) binding site [chemical binding]; other site 446462011840 active site 446462011841 putative substrate binding site [chemical binding]; other site 446462011842 Erythronolide synthase docking; Region: Docking; pfam08990 446462011843 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462011844 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011845 active site 446462011846 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011847 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462011848 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462011849 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462011850 putative NADP binding site [chemical binding]; other site 446462011851 active site 446462011852 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011853 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011854 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011855 active site 446462011856 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462011857 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011858 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011859 Erythronolide synthase docking; Region: Docking; pfam08990 446462011860 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462011861 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011862 active site 446462011863 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011864 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462011865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011866 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462011867 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462011868 putative NADP binding site [chemical binding]; other site 446462011869 active site 446462011870 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011871 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011872 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011873 active site 446462011874 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011875 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462011876 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462011877 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462011878 putative NADP binding site [chemical binding]; other site 446462011879 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462011880 active site 446462011881 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011883 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011884 active site 446462011885 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462011886 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011887 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011888 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462011889 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462011890 active site 446462011891 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462011892 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462011893 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462011894 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462011895 putative NADP binding site [chemical binding]; other site 446462011896 KR domain; Region: KR; pfam08659 446462011897 active site 446462011898 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462011899 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462011900 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462011901 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 446462011902 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462011903 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462011904 catalytic residue [active] 446462011905 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 446462011906 SnoaL-like domain; Region: SnoaL_3; pfam13474 446462011907 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462011908 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462011909 active site 446462011910 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446462011911 SCP-2 sterol transfer family; Region: SCP2; cl01225 446462011912 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 446462011913 dinuclear metal binding motif [ion binding]; other site 446462011914 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462011915 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462011916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462011917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462011918 dimerization interface [polypeptide binding]; other site 446462011919 DNA binding residues [nucleotide binding] 446462011920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462011921 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 446462011922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011923 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462011924 NAD(P) binding site [chemical binding]; other site 446462011925 active site 446462011926 Cupin; Region: Cupin_6; pfam12852 446462011927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462011928 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462011929 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446462011930 hypothetical protein; Provisional; Region: PRK10621 446462011931 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462011932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462011933 sequence-specific DNA binding site [nucleotide binding]; other site 446462011934 salt bridge; other site 446462011935 short chain dehydrogenase; Provisional; Region: PRK05854 446462011936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462011937 NAD(P) binding site [chemical binding]; other site 446462011938 active site 446462011939 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 446462011940 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446462011941 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462011942 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462011943 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446462011944 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 446462011945 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462011946 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011947 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446462011948 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446462011949 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 446462011950 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 446462011951 FAD binding pocket [chemical binding]; other site 446462011952 FAD binding motif [chemical binding]; other site 446462011953 phosphate binding motif [ion binding]; other site 446462011954 beta-alpha-beta structure motif; other site 446462011955 NAD(p) ribose binding residues [chemical binding]; other site 446462011956 NAD binding pocket [chemical binding]; other site 446462011957 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 446462011958 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446462011959 catalytic loop [active] 446462011960 iron binding site [ion binding]; other site 446462011961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462011962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011963 GON domain; Region: GON; pfam08685 446462011964 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446462011965 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446462011966 acyl-activating enzyme (AAE) consensus motif; other site 446462011967 putative AMP binding site [chemical binding]; other site 446462011968 putative active site [active] 446462011969 putative CoA binding site [chemical binding]; other site 446462011970 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446462011971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462011972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462011973 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446462011974 FMN binding site [chemical binding]; other site 446462011975 dimer interface [polypeptide binding]; other site 446462011976 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 446462011977 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462011978 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462011979 active site 446462011980 ATP binding site [chemical binding]; other site 446462011981 substrate binding site [chemical binding]; other site 446462011982 activation loop (A-loop); other site 446462011983 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462011984 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446462011985 NAD(P) binding site [chemical binding]; other site 446462011986 Protein of unknown function, DUF608; Region: DUF608; pfam04685 446462011987 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446462011988 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462011989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462011990 SnoaL-like domain; Region: SnoaL_2; pfam12680 446462011991 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 446462011992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462011993 FeS/SAM binding site; other site 446462011994 Condensation domain; Region: Condensation; pfam00668 446462011995 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462011996 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462011997 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462011998 Condensation domain; Region: Condensation; pfam00668 446462011999 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462012000 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462012001 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012002 acyl-activating enzyme (AAE) consensus motif; other site 446462012003 AMP binding site [chemical binding]; other site 446462012004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012005 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446462012006 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462012007 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 446462012008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462012009 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 446462012010 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012011 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012012 acyl-activating enzyme (AAE) consensus motif; other site 446462012013 AMP binding site [chemical binding]; other site 446462012014 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462012015 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 446462012016 Thioesterase domain; Region: Thioesterase; pfam00975 446462012017 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462012018 Cytochrome P450; Region: p450; cl12078 446462012019 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 446462012020 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012021 acyl-activating enzyme (AAE) consensus motif; other site 446462012022 AMP binding site [chemical binding]; other site 446462012023 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012024 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 446462012025 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 446462012026 Condensation domain; Region: Condensation; pfam00668 446462012027 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462012028 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012029 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462012030 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012031 acyl-activating enzyme (AAE) consensus motif; other site 446462012032 AMP binding site [chemical binding]; other site 446462012033 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012034 Thioesterase domain; Region: Thioesterase; pfam00975 446462012035 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462012036 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 446462012037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462012038 catalytic residue [active] 446462012039 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446462012040 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446462012041 dimer interface [polypeptide binding]; other site 446462012042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462012043 catalytic residue [active] 446462012044 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446462012045 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 446462012046 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446462012047 tetramer interface [polypeptide binding]; other site 446462012048 MbtH-like protein; Region: MbtH; cl01279 446462012049 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012050 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012051 acyl-activating enzyme (AAE) consensus motif; other site 446462012052 AMP binding site [chemical binding]; other site 446462012053 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012054 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 446462012055 Condensation domain; Region: Condensation; pfam00668 446462012056 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462012057 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462012058 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012059 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012060 acyl-activating enzyme (AAE) consensus motif; other site 446462012061 AMP binding site [chemical binding]; other site 446462012062 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012063 Protein of unknown function (DUF419); Region: DUF419; cl15265 446462012064 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446462012065 Part of AAA domain; Region: AAA_19; pfam13245 446462012066 Family description; Region: UvrD_C_2; pfam13538 446462012067 MMPL family; Region: MMPL; pfam03176 446462012068 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446462012069 Histidine kinase; Region: HisKA_3; pfam07730 446462012070 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462012071 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462012072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462012073 active site 446462012074 phosphorylation site [posttranslational modification] 446462012075 intermolecular recognition site; other site 446462012076 dimerization interface [polypeptide binding]; other site 446462012077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462012078 DNA binding residues [nucleotide binding] 446462012079 dimerization interface [polypeptide binding]; other site 446462012080 VanZ like family; Region: VanZ; pfam04892 446462012081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462012082 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462012083 dimerization interface [polypeptide binding]; other site 446462012084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462012085 dimer interface [polypeptide binding]; other site 446462012086 phosphorylation site [posttranslational modification] 446462012087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462012088 ATP binding site [chemical binding]; other site 446462012089 G-X-G motif; other site 446462012090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462012091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462012092 active site 446462012093 phosphorylation site [posttranslational modification] 446462012094 intermolecular recognition site; other site 446462012095 dimerization interface [polypeptide binding]; other site 446462012096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462012097 DNA binding site [nucleotide binding] 446462012098 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446462012099 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 446462012100 active site 446462012101 catalytic triad [active] 446462012102 oxyanion hole [active] 446462012103 Cellulose binding domain; Region: CBM_2; pfam00553 446462012104 EspG family; Region: ESX-1_EspG; pfam14011 446462012105 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462012106 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446462012107 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 446462012108 META domain; Region: META; pfam03724 446462012109 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 446462012110 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462012111 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446462012112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462012113 PAS domain; Region: PAS_9; pfam13426 446462012114 putative active site [active] 446462012115 heme pocket [chemical binding]; other site 446462012116 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462012117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462012118 dimerization interface [polypeptide binding]; other site 446462012119 DNA binding residues [nucleotide binding] 446462012120 Phosphotransferase enzyme family; Region: APH; pfam01636 446462012121 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446462012122 substrate binding site [chemical binding]; other site 446462012123 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 446462012124 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462012125 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462012126 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 446462012127 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462012128 Radical SAM superfamily; Region: Radical_SAM; pfam04055 446462012129 FeS/SAM binding site; other site 446462012130 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 446462012131 peptide synthase; Provisional; Region: PRK12316 446462012132 RHS Repeat; Region: RHS_repeat; cl11982 446462012133 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446462012134 RHS Repeat; Region: RHS_repeat; pfam05593 446462012135 RHS Repeat; Region: RHS_repeat; cl11982 446462012136 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 446462012137 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 446462012138 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 446462012139 RHS Repeat; Region: RHS_repeat; pfam05593 446462012140 RHS Repeat; Region: RHS_repeat; pfam05593 446462012141 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446462012142 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 446462012143 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446462012144 Int/Topo IB signature motif; other site 446462012145 DNA binding site [nucleotide binding] 446462012146 active site 446462012147 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446462012148 active site 446462012149 Family description; Region: VCBS; pfam13517 446462012150 Family description; Region: VCBS; pfam13517 446462012151 Family description; Region: VCBS; pfam13517 446462012152 Short repeats of unknown function; Region: ALF; pfam03752 446462012153 Short repeats of unknown function; Region: ALF; pfam03752 446462012154 Short repeats of unknown function; Region: ALF; pfam03752 446462012155 Homeodomain-like domain; Region: HTH_23; pfam13384 446462012156 Winged helix-turn helix; Region: HTH_29; pfam13551 446462012157 Homeodomain-like domain; Region: HTH_32; pfam13565 446462012158 DDE superfamily endonuclease; Region: DDE_3; pfam13358 446462012159 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 446462012160 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 446462012161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462012162 non-specific DNA binding site [nucleotide binding]; other site 446462012163 salt bridge; other site 446462012164 sequence-specific DNA binding site [nucleotide binding]; other site 446462012165 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446462012166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462012167 motif II; other site 446462012168 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446462012169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462012170 motif II; other site 446462012171 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 446462012172 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462012173 DDE superfamily endonuclease; Region: DDE_4; pfam13359 446462012174 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446462012175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462012176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462012177 S-adenosylmethionine binding site [chemical binding]; other site 446462012178 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012179 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012180 acyl-activating enzyme (AAE) consensus motif; other site 446462012181 AMP binding site [chemical binding]; other site 446462012182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012183 Condensation domain; Region: Condensation; pfam00668 446462012184 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462012185 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012186 acyl-activating enzyme (AAE) consensus motif; other site 446462012187 AMP binding site [chemical binding]; other site 446462012188 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012189 Thioesterase domain; Region: Thioesterase; pfam00975 446462012190 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462012191 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012192 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012193 acyl-activating enzyme (AAE) consensus motif; other site 446462012194 AMP binding site [chemical binding]; other site 446462012195 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012196 Condensation domain; Region: Condensation; pfam00668 446462012197 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462012198 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012199 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012200 acyl-activating enzyme (AAE) consensus motif; other site 446462012201 AMP binding site [chemical binding]; other site 446462012202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012203 Condensation domain; Region: Condensation; pfam00668 446462012204 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462012205 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012206 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012207 acyl-activating enzyme (AAE) consensus motif; other site 446462012208 AMP binding site [chemical binding]; other site 446462012209 Condensation domain; Region: Condensation; pfam00668 446462012210 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 446462012211 Condensation domain; Region: Condensation; pfam00668 446462012212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462012213 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 446462012214 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 446462012215 dimer interface [polypeptide binding]; other site 446462012216 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 446462012217 active site 446462012218 Fe binding site [ion binding]; other site 446462012219 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462012220 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 446462012221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462012222 homodimer interface [polypeptide binding]; other site 446462012223 catalytic residue [active] 446462012224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462012226 putative substrate translocation pore; other site 446462012227 MbtH-like protein; Region: MbtH; cl01279 446462012228 D-cysteine desulfhydrase; Validated; Region: PRK03910 446462012229 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446462012230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462012231 catalytic residue [active] 446462012232 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 446462012233 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462012234 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462012235 Cytochrome P450; Region: p450; cl12078 446462012236 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446462012237 DNA binding site [nucleotide binding] 446462012238 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462012239 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 446462012240 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 446462012241 active site 446462012242 substrate binding site [chemical binding]; other site 446462012243 FMN binding site [chemical binding]; other site 446462012244 putative catalytic residues [active] 446462012245 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462012246 Cytochrome P450; Region: p450; cl12078 446462012247 MbtH-like protein; Region: MbtH; cl01279 446462012248 Lipase (class 2); Region: Lipase_2; pfam01674 446462012249 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462012250 hypothetical protein; Provisional; Region: PRK06753 446462012251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012252 NAD(P) binding site [chemical binding]; other site 446462012253 active site 446462012254 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462012255 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462012256 active site 446462012257 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462012258 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462012259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012260 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 446462012261 Enoylreductase; Region: PKS_ER; smart00829 446462012262 NAD(P) binding site [chemical binding]; other site 446462012263 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462012264 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462012265 putative NADP binding site [chemical binding]; other site 446462012266 active site 446462012267 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462012268 Condensation domain; Region: Condensation; pfam00668 446462012269 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462012270 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012271 acyl-activating enzyme (AAE) consensus motif; other site 446462012272 AMP binding site [chemical binding]; other site 446462012273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012274 Condensation domain; Region: Condensation; pfam00668 446462012275 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462012276 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462012277 acyl-activating enzyme (AAE) consensus motif; other site 446462012278 AMP binding site [chemical binding]; other site 446462012279 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462012280 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 446462012281 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462012282 Cytochrome P450; Region: p450; cl12078 446462012283 Cytochrome P450; Region: p450; cl12078 446462012284 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446462012285 Carboxylesterase family; Region: COesterase; pfam00135 446462012286 substrate binding pocket [chemical binding]; other site 446462012287 catalytic triad [active] 446462012288 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 446462012289 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462012290 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462012291 DNA binding site [nucleotide binding] 446462012292 domain linker motif; other site 446462012293 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462012294 ligand binding site [chemical binding]; other site 446462012295 dimerization interface [polypeptide binding]; other site 446462012296 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462012297 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462012298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462012299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462012300 dimer interface [polypeptide binding]; other site 446462012301 conserved gate region; other site 446462012302 putative PBP binding loops; other site 446462012303 ABC-ATPase subunit interface; other site 446462012304 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462012305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462012306 ABC-ATPase subunit interface; other site 446462012307 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446462012308 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462012309 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446462012310 Uncharacterized conserved protein [Function unknown]; Region: COG3538 446462012311 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 446462012312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012314 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446462012315 hypothetical protein; Provisional; Region: PRK07236 446462012316 hypothetical protein; Provisional; Region: PRK07236 446462012317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 446462012318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462012319 classical (c) SDRs; Region: SDR_c; cd05233 446462012320 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446462012321 NAD(P) binding site [chemical binding]; other site 446462012322 active site 446462012323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012325 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446462012326 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462012327 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462012328 putative sugar binding sites [chemical binding]; other site 446462012329 Q-X-W motif; other site 446462012330 short chain dehydrogenase; Provisional; Region: PRK06523 446462012331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012332 NAD(P) binding site [chemical binding]; other site 446462012333 active site 446462012334 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446462012335 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462012336 DNA binding residues [nucleotide binding] 446462012337 drug binding residues [chemical binding]; other site 446462012338 dimer interface [polypeptide binding]; other site 446462012339 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 446462012340 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 446462012341 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462012342 DNA binding residues [nucleotide binding] 446462012343 putative dimer interface [polypeptide binding]; other site 446462012344 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462012345 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462012346 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462012347 acyl-activating enzyme (AAE) consensus motif; other site 446462012348 acyl-activating enzyme (AAE) consensus motif; other site 446462012349 AMP binding site [chemical binding]; other site 446462012350 active site 446462012351 CoA binding site [chemical binding]; other site 446462012352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462012353 S-adenosylmethionine binding site [chemical binding]; other site 446462012354 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 446462012355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446462012356 non-specific DNA binding site [nucleotide binding]; other site 446462012357 salt bridge; other site 446462012358 sequence-specific DNA binding site [nucleotide binding]; other site 446462012359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462012360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462012361 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446462012362 putative dimerization interface [polypeptide binding]; other site 446462012363 hypothetical protein; Provisional; Region: PRK06815 446462012364 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446462012365 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462012366 catalytic residue [active] 446462012367 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446462012368 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446462012369 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446462012370 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462012371 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 446462012372 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 446462012373 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 446462012374 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462012375 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446462012376 putative NAD(P) binding site [chemical binding]; other site 446462012377 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462012378 MarR family; Region: MarR; pfam01047 446462012379 MarR family; Region: MarR_2; cl17246 446462012380 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462012381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462012382 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462012383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462012384 active site 446462012385 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 446462012386 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446462012387 NAD binding site [chemical binding]; other site 446462012388 catalytic Zn binding site [ion binding]; other site 446462012389 substrate binding site [chemical binding]; other site 446462012390 structural Zn binding site [ion binding]; other site 446462012391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462012393 putative substrate translocation pore; other site 446462012394 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446462012395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462012397 putative substrate translocation pore; other site 446462012398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462012399 AMP-binding enzyme; Region: AMP-binding; pfam00501 446462012400 acyl-activating enzyme (AAE) consensus motif; other site 446462012401 AMP binding site [chemical binding]; other site 446462012402 active site 446462012403 CoA binding site [chemical binding]; other site 446462012404 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446462012405 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 446462012406 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446462012407 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 446462012408 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 446462012409 tetramer interface [polypeptide binding]; other site 446462012410 active site 446462012411 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 446462012412 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446462012413 classical (c) SDRs; Region: SDR_c; cd05233 446462012414 NAD(P) binding site [chemical binding]; other site 446462012415 active site 446462012416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446462012417 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446462012418 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446462012419 active site 446462012420 catalytic triad [active] 446462012421 dimer interface [polypeptide binding]; other site 446462012422 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446462012423 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446462012424 Pectinesterase; Region: Pectinesterase; pfam01095 446462012425 putative pectinesterase; Region: PLN02432; cl01911 446462012426 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 446462012427 active site 446462012428 catalytic triad [active] 446462012429 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462012430 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446462012431 active site 446462012432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 446462012433 phosphorylation site [posttranslational modification] 446462012434 intermolecular recognition site; other site 446462012435 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462012436 ABC transporter signature motif; other site 446462012437 Walker B; other site 446462012438 D-loop; other site 446462012439 H-loop/switch region; other site 446462012440 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446462012441 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446462012442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462012443 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 446462012444 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462012445 active site 446462012446 catalytic triad [active] 446462012447 oxyanion hole [active] 446462012448 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462012449 active site 446462012450 catalytic triad [active] 446462012451 oxyanion hole [active] 446462012452 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 446462012453 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462012454 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462012455 active site 446462012456 ATP binding site [chemical binding]; other site 446462012457 substrate binding site [chemical binding]; other site 446462012458 activation loop (A-loop); other site 446462012459 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446462012460 Pectate lyase; Region: Pec_lyase_C; cl01593 446462012461 Cellulose binding domain; Region: CBM_2; cl17741 446462012462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012466 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 446462012467 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462012468 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 446462012469 acyl-activating enzyme (AAE) consensus motif; other site 446462012470 putative AMP binding site [chemical binding]; other site 446462012471 putative active site [active] 446462012472 putative CoA binding site [chemical binding]; other site 446462012473 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 446462012474 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462012475 NAD(P) binding site [chemical binding]; other site 446462012476 catalytic residues [active] 446462012477 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 446462012478 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462012479 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462012480 Putative sensor; Region: Sensor; pfam13796 446462012481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462012482 Histidine kinase; Region: HisKA_3; pfam07730 446462012483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462012484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462012485 active site 446462012486 phosphorylation site [posttranslational modification] 446462012487 intermolecular recognition site; other site 446462012488 dimerization interface [polypeptide binding]; other site 446462012489 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462012490 DNA binding residues [nucleotide binding] 446462012491 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462012492 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462012493 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446462012494 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462012495 cyclase homology domain; Region: CHD; cd07302 446462012496 metal binding site [ion binding]; metal-binding site 446462012497 AAA ATPase domain; Region: AAA_16; pfam13191 446462012498 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462012499 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 446462012500 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462012501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462012502 catalytic residue [active] 446462012503 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446462012504 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 446462012505 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446462012506 active site 446462012507 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 446462012508 Erythronolide synthase docking; Region: Docking; pfam08990 446462012509 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462012510 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462012511 active site 446462012512 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462012513 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462012514 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462012515 putative NADP binding site [chemical binding]; other site 446462012516 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462012517 active site 446462012518 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462012519 thioester reductase domain; Region: Thioester-redct; TIGR01746 446462012520 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 446462012521 putative NAD(P) binding site [chemical binding]; other site 446462012522 active site 446462012523 putative substrate binding site [chemical binding]; other site 446462012524 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462012525 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 446462012526 active site 446462012527 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462012528 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462012529 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462012530 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446462012531 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462012532 active site 446462012533 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462012534 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462012535 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446462012536 putative NADP binding site [chemical binding]; other site 446462012537 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462012538 active site 446462012539 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462012540 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462012541 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462012542 active site 446462012543 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462012544 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462012545 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462012546 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446462012547 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446462012548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012549 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446462012550 NAD(P) binding site [chemical binding]; other site 446462012551 active site 446462012552 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 446462012553 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462012554 active site 446462012555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462012557 putative substrate translocation pore; other site 446462012558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012559 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462012560 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446462012561 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 446462012562 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462012563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462012564 active site 446462012565 SnoaL-like domain; Region: SnoaL_2; pfam12680 446462012566 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462012567 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 446462012568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462012569 Walker A/P-loop; other site 446462012570 ATP binding site [chemical binding]; other site 446462012571 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 446462012572 putative active site [active] 446462012573 putative metal-binding site [ion binding]; other site 446462012574 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 446462012575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 446462012576 proline aminopeptidase P II; Provisional; Region: PRK10879 446462012577 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 446462012578 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 446462012579 active site 446462012580 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462012581 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446462012582 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462012583 Walker A/P-loop; other site 446462012584 ATP binding site [chemical binding]; other site 446462012585 Q-loop/lid; other site 446462012586 ABC transporter signature motif; other site 446462012587 Walker B; other site 446462012588 D-loop; other site 446462012589 H-loop/switch region; other site 446462012590 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446462012591 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446462012592 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462012593 Walker A/P-loop; other site 446462012594 ATP binding site [chemical binding]; other site 446462012595 Q-loop/lid; other site 446462012596 ABC transporter signature motif; other site 446462012597 Walker B; other site 446462012598 D-loop; other site 446462012599 H-loop/switch region; other site 446462012600 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446462012601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462012602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462012603 dimer interface [polypeptide binding]; other site 446462012604 conserved gate region; other site 446462012605 putative PBP binding loops; other site 446462012606 ABC-ATPase subunit interface; other site 446462012607 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462012608 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446462012609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462012610 dimer interface [polypeptide binding]; other site 446462012611 conserved gate region; other site 446462012612 putative PBP binding loops; other site 446462012613 ABC-ATPase subunit interface; other site 446462012614 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446462012615 peptide binding site [polypeptide binding]; other site 446462012616 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462012617 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 446462012618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462012619 DNA-binding site [nucleotide binding]; DNA binding site 446462012620 FCD domain; Region: FCD; pfam07729 446462012621 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 446462012622 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 446462012623 dimer interface [polypeptide binding]; other site 446462012624 NADP binding site [chemical binding]; other site 446462012625 catalytic residues [active] 446462012626 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 446462012627 Proline racemase; Region: Pro_racemase; pfam05544 446462012628 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446462012629 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446462012630 inhibitor site; inhibition site 446462012631 active site 446462012632 dimer interface [polypeptide binding]; other site 446462012633 catalytic residue [active] 446462012634 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446462012635 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 446462012636 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446462012637 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462012638 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446462012639 intersubunit interface [polypeptide binding]; other site 446462012640 active site 446462012641 catalytic residue [active] 446462012642 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462012643 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462012644 DNA binding site [nucleotide binding] 446462012645 domain linker motif; other site 446462012646 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462012647 dimerization interface [polypeptide binding]; other site 446462012648 ligand binding site [chemical binding]; other site 446462012649 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446462012650 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446462012651 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446462012652 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 446462012653 hypothetical protein; Provisional; Region: PRK08204 446462012654 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462012655 active site 446462012656 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446462012657 CBD_II domain; Region: CBD_II; smart00637 446462012658 wnt family; Region: wnt; pfam00110 446462012659 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 446462012660 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446462012661 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 446462012662 Walker A/P-loop; other site 446462012663 ATP binding site [chemical binding]; other site 446462012664 Q-loop/lid; other site 446462012665 ABC transporter signature motif; other site 446462012666 Walker B; other site 446462012667 D-loop; other site 446462012668 H-loop/switch region; other site 446462012669 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462012670 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446462012671 DNA binding residues [nucleotide binding] 446462012672 TM1410 hypothetical-related protein; Region: DUF297; cl00997 446462012673 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 446462012674 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 446462012675 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 446462012676 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 446462012677 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 446462012678 homodimer interface [polypeptide binding]; other site 446462012679 ligand binding site [chemical binding]; other site 446462012680 NAD(P) binding site [chemical binding]; other site 446462012681 trimer interface B [polypeptide binding]; other site 446462012682 trimer interface A [polypeptide binding]; other site 446462012683 YwiC-like protein; Region: YwiC; pfam14256 446462012684 potential frameshift: common BLAST hit: gi|145224073|ref|YP_001134751.1| multicopper oxidase, type 3 446462012685 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 446462012686 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 446462012687 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 446462012688 Predicted transcriptional regulator [Transcription]; Region: COG2345 446462012689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462012690 putative DNA binding site [nucleotide binding]; other site 446462012691 dimerization interface [polypeptide binding]; other site 446462012692 putative Zn2+ binding site [ion binding]; other site 446462012693 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 446462012694 active site 446462012695 Zn binding site [ion binding]; other site 446462012696 EF-hand domain pair; Region: EF_hand_5; pfam13499 446462012697 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 446462012698 Leucine carboxyl methyltransferase; Region: LCM; cl01306 446462012699 Predicted membrane protein [Function unknown]; Region: COG4270 446462012700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012702 WHG domain; Region: WHG; pfam13305 446462012703 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 446462012704 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462012705 intersubunit interface [polypeptide binding]; other site 446462012706 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 446462012707 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462012708 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 446462012709 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446462012710 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 446462012711 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446462012712 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446462012713 ABC-ATPase subunit interface; other site 446462012714 dimer interface [polypeptide binding]; other site 446462012715 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 446462012716 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 446462012717 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 446462012718 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 446462012719 WxL domain surface cell wall-binding; Region: WxL; pfam13731 446462012720 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 446462012721 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 446462012722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012723 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462012724 putative substrate translocation pore; other site 446462012725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462012726 Domain of unknown function (DUF364); Region: DUF364; pfam04016 446462012727 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 446462012728 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446462012729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462012730 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 446462012731 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446462012732 putative ligand binding residues [chemical binding]; other site 446462012733 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462012734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462012735 Walker A/P-loop; other site 446462012736 ATP binding site [chemical binding]; other site 446462012737 Q-loop/lid; other site 446462012738 ABC transporter signature motif; other site 446462012739 Walker B; other site 446462012740 H-loop/switch region; other site 446462012741 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462012742 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462012743 dimer interface [polypeptide binding]; other site 446462012744 putative PBP binding regions; other site 446462012745 ABC-ATPase subunit interface; other site 446462012746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462012747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012749 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446462012750 Amidase; Region: Amidase; cl11426 446462012751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446462012752 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 446462012753 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 446462012754 dimer interface [polypeptide binding]; other site 446462012755 putative CheW interface [polypeptide binding]; other site 446462012756 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 446462012757 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 446462012758 active site 446462012759 DNA binding site [nucleotide binding] 446462012760 Int/Topo IB signature motif; other site 446462012761 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 446462012762 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462012763 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446462012764 dimerization interface [polypeptide binding]; other site 446462012765 substrate binding pocket [chemical binding]; other site 446462012766 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446462012767 classical (c) SDRs; Region: SDR_c; cd05233 446462012768 NAD(P) binding site [chemical binding]; other site 446462012769 active site 446462012770 Amidohydrolase; Region: Amidohydro_2; pfam04909 446462012771 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462012772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012774 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462012775 NAD(P) binding site [chemical binding]; other site 446462012776 active site 446462012777 putative inner membrane protein; Provisional; Region: PRK11099 446462012778 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462012779 hypothetical protein; Provisional; Region: PRK06184 446462012780 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 446462012781 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462012782 AAA ATPase domain; Region: AAA_16; pfam13191 446462012783 Predicted ATPase [General function prediction only]; Region: COG3903 446462012784 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446462012785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012786 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462012787 putative substrate translocation pore; other site 446462012788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012792 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446462012793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012794 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446462012795 NAD(P) binding site [chemical binding]; other site 446462012796 Restriction endonuclease; Region: Mrr_cat; pfam04471 446462012797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462012798 NACHT domain; Region: NACHT; pfam05729 446462012799 Walker A/P-loop; other site 446462012800 ATP binding site [chemical binding]; other site 446462012801 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462012802 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446462012803 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446462012804 G2 box; other site 446462012805 Switch I region; other site 446462012806 G3 box; other site 446462012807 Switch II region; other site 446462012808 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446462012809 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 446462012810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462012811 ATP binding site [chemical binding]; other site 446462012812 Mg2+ binding site [ion binding]; other site 446462012813 G-X-G motif; other site 446462012814 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462012815 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 446462012816 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462012817 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462012818 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462012819 Cupin domain; Region: Cupin_2; pfam07883 446462012820 Methane oxygenase PmoA; Region: PmoA; pfam14100 446462012821 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 446462012822 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446462012823 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446462012824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462012825 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446462012826 putative dimerization interface [polypeptide binding]; other site 446462012827 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 446462012828 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462012829 inhibitor-cofactor binding pocket; inhibition site 446462012830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462012831 catalytic residue [active] 446462012832 Domain of unknown function (DUF385); Region: DUF385; cl04387 446462012833 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462012834 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462012835 putative sugar binding sites [chemical binding]; other site 446462012836 Q-X-W motif; other site 446462012837 Septum formation; Region: Septum_form; pfam13845 446462012838 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462012839 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 446462012840 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462012841 Cytochrome P450; Region: p450; cl12078 446462012842 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462012843 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 446462012844 Ligand binding site; other site 446462012845 Putative Catalytic site; other site 446462012846 DXD motif; other site 446462012847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012850 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446462012851 NAD(P) binding site [chemical binding]; other site 446462012852 active site 446462012853 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446462012854 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462012855 homodimer interface [polypeptide binding]; other site 446462012856 active site 446462012857 TDP-binding site; other site 446462012858 acceptor substrate-binding pocket; other site 446462012859 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446462012860 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462012861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462012862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012863 NAD(P) binding site [chemical binding]; other site 446462012864 active site 446462012865 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446462012866 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462012867 homodimer interface [polypeptide binding]; other site 446462012868 active site 446462012869 TDP-binding site; other site 446462012870 acceptor substrate-binding pocket; other site 446462012871 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446462012872 Cytochrome P450; Region: p450; cl12078 446462012873 Protein kinase domain; Region: Pkinase; pfam00069 446462012874 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462012875 active site 446462012876 ATP binding site [chemical binding]; other site 446462012877 substrate binding site [chemical binding]; other site 446462012878 activation loop (A-loop); other site 446462012879 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446462012880 active site 446462012881 zinc binding site [ion binding]; other site 446462012882 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 446462012883 Flavoprotein; Region: Flavoprotein; pfam02441 446462012884 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446462012885 active site 2 [active] 446462012886 active site 1 [active] 446462012887 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 446462012888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012889 NAD(P) binding site [chemical binding]; other site 446462012890 active site 446462012891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012892 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446462012893 NAD(P) binding site [chemical binding]; other site 446462012894 active site 446462012895 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462012896 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462012897 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462012898 active site 446462012899 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462012900 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462012901 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446462012902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462012903 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446462012904 short chain dehydrogenase; Region: adh_short; pfam00106 446462012905 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446462012906 HTH-like domain; Region: HTH_21; pfam13276 446462012907 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462012908 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462012909 acyl-activating enzyme (AAE) consensus motif; other site 446462012910 AMP binding site [chemical binding]; other site 446462012911 active site 446462012912 CoA binding site [chemical binding]; other site 446462012913 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446462012914 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446462012915 dimer interface [polypeptide binding]; other site 446462012916 active site 446462012917 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462012918 NAD(P) binding site [chemical binding]; other site 446462012919 catalytic residues [active] 446462012920 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462012921 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 446462012922 NAD(P) binding site [chemical binding]; other site 446462012923 catalytic residues [active] 446462012924 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 446462012925 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446462012926 PYR/PP interface [polypeptide binding]; other site 446462012927 dimer interface [polypeptide binding]; other site 446462012928 TPP binding site [chemical binding]; other site 446462012929 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446462012930 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 446462012931 TPP-binding site [chemical binding]; other site 446462012932 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 446462012933 AMP-binding enzyme; Region: AMP-binding; pfam00501 446462012934 acyl-activating enzyme (AAE) consensus motif; other site 446462012935 active site 446462012936 acyl carrier protein; Provisional; Region: acpP; PRK00982 446462012937 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462012938 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462012939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462012940 Walker A/P-loop; other site 446462012941 ATP binding site [chemical binding]; other site 446462012942 Q-loop/lid; other site 446462012943 ABC transporter signature motif; other site 446462012944 Walker B; other site 446462012945 D-loop; other site 446462012946 H-loop/switch region; other site 446462012947 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446462012948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012949 putative substrate translocation pore; other site 446462012950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462012952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462012953 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446462012954 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446462012955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446462012956 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462012957 non-specific DNA binding site [nucleotide binding]; other site 446462012958 salt bridge; other site 446462012959 sequence-specific DNA binding site [nucleotide binding]; other site 446462012960 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446462012961 RHS Repeat; Region: RHS_repeat; pfam05593 446462012962 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446462012963 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 446462012964 protein-splicing catalytic site; other site 446462012965 thioester formation/cholesterol transfer; other site 446462012966 Pretoxin HINT domain; Region: PT-HINT; pfam07591 446462012967 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462012968 intermolecular salt bridges; other site 446462012969 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446462012970 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446462012971 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462012972 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446462012973 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446462012974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462012975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462012976 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446462012977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462012978 Coenzyme A binding pocket [chemical binding]; other site 446462012979 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462012980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446462012981 Walker A motif; other site 446462012982 ATP binding site [chemical binding]; other site 446462012983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462012984 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 446462012985 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 446462012986 coproporphyrinogen III oxidase; Validated; Region: PRK08208 446462012987 cytidylate kinase, putative; Region: cyt_kin_arch; TIGR02173 446462012988 AAA domain; Region: AAA_17; pfam13207 446462012989 hypothetical protein; Provisional; Region: PRK07906 446462012990 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446462012991 putative metal binding site [ion binding]; other site 446462012992 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446462012993 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462012994 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462012995 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446462012996 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446462012997 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446462012998 Walker A/P-loop; other site 446462012999 ATP binding site [chemical binding]; other site 446462013000 Q-loop/lid; other site 446462013001 ABC transporter signature motif; other site 446462013002 Walker B; other site 446462013003 D-loop; other site 446462013004 H-loop/switch region; other site 446462013005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462013006 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446462013007 NMT1/THI5 like; Region: NMT1; pfam09084 446462013008 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462013009 substrate binding pocket [chemical binding]; other site 446462013010 membrane-bound complex binding site; other site 446462013011 hinge residues; other site 446462013012 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446462013013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462013014 dihydroorotase, multifunctional complex type; Region: pyrC_multi; TIGR00857 446462013015 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 446462013016 active site 446462013017 Kelch motif; Region: Kelch_1; pfam01344 446462013018 Kelch motif; Region: Kelch_1; pfam01344 446462013019 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 446462013020 Kelch domain; Region: Kelch; smart00612 446462013021 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 446462013022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462013023 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446462013024 dimerization interface [polypeptide binding]; other site 446462013025 substrate binding pocket [chemical binding]; other site 446462013026 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462013027 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462013028 active site 446462013029 ATP binding site [chemical binding]; other site 446462013030 substrate binding site [chemical binding]; other site 446462013031 activation loop (A-loop); other site 446462013032 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446462013033 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 446462013034 FMN binding site [chemical binding]; other site 446462013035 active site 446462013036 substrate binding site [chemical binding]; other site 446462013037 catalytic residue [active] 446462013038 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462013039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462013040 putative Zn2+ binding site [ion binding]; other site 446462013041 putative DNA binding site [nucleotide binding]; other site 446462013042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462013043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462013044 DNA binding residues [nucleotide binding] 446462013045 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462013046 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 446462013047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462013048 DNA-binding site [nucleotide binding]; DNA binding site 446462013049 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462013050 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462013051 Walker A/P-loop; other site 446462013052 ATP binding site [chemical binding]; other site 446462013053 Q-loop/lid; other site 446462013054 ABC transporter signature motif; other site 446462013055 Walker B; other site 446462013056 D-loop; other site 446462013057 H-loop/switch region; other site 446462013058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446462013059 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446462013060 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 446462013061 putative PBP binding regions; other site 446462013062 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446462013063 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446462013064 intersubunit interface [polypeptide binding]; other site 446462013065 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 446462013066 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446462013067 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 446462013068 homodimer interface [polypeptide binding]; other site 446462013069 substrate-cofactor binding pocket; other site 446462013070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462013071 catalytic residue [active] 446462013072 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 446462013073 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446462013074 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446462013075 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446462013076 active site 446462013077 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446462013078 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446462013079 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462013080 acyl-CoA synthetase; Validated; Region: PRK05850 446462013081 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 446462013082 acyl-activating enzyme (AAE) consensus motif; other site 446462013083 active site 446462013084 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462013085 Condensation domain; Region: Condensation; pfam00668 446462013086 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462013087 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462013088 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462013089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462013090 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462013091 AMP binding site [chemical binding]; other site 446462013092 acyl-activating enzyme (AAE) consensus motif; other site 446462013093 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462013094 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 446462013095 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446462013096 active site 446462013097 Condensation domain; Region: Condensation; pfam00668 446462013098 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462013099 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462013100 active site 446462013101 catalytic tetrad [active] 446462013102 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446462013103 phosphate binding site [ion binding]; other site 446462013104 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462013105 anti sigma factor interaction site; other site 446462013106 regulatory phosphorylation site [posttranslational modification]; other site 446462013107 B12 binding domain; Region: B12-binding_2; pfam02607 446462013108 B12 binding domain; Region: B12-binding; pfam02310 446462013109 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 446462013110 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462013111 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 446462013112 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 446462013113 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446462013114 active site 446462013115 catalytic triad [active] 446462013116 oxyanion hole [active] 446462013117 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462013118 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 446462013119 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462013120 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462013121 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462013122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462013123 putative substrate translocation pore; other site 446462013124 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 446462013125 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 446462013126 Glycerate kinase family; Region: Gly_kinase; cl00841 446462013127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462013128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013129 dimerization interface [polypeptide binding]; other site 446462013130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462013131 dimer interface [polypeptide binding]; other site 446462013132 phosphorylation site [posttranslational modification] 446462013133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462013134 ATP binding site [chemical binding]; other site 446462013135 G-X-G motif; other site 446462013136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462013137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462013138 active site 446462013139 phosphorylation site [posttranslational modification] 446462013140 intermolecular recognition site; other site 446462013141 dimerization interface [polypeptide binding]; other site 446462013142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462013143 DNA binding site [nucleotide binding] 446462013144 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446462013145 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446462013146 catalytic residue [active] 446462013147 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 446462013148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462013149 putative substrate translocation pore; other site 446462013150 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446462013151 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462013152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462013153 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446462013154 dimerization interface [polypeptide binding]; other site 446462013155 substrate binding pocket [chemical binding]; other site 446462013156 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446462013157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462013158 NAD(P) binding site [chemical binding]; other site 446462013159 active site 446462013160 Survival protein SurE; Region: SurE; cl00448 446462013161 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446462013162 substrate binding site [chemical binding]; other site 446462013163 ATP binding site [chemical binding]; other site 446462013164 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 446462013165 polypeptide substrate binding site [polypeptide binding]; other site 446462013166 active site 446462013167 Uncharacterized conserved protein [Function unknown]; Region: COG3349 446462013168 Protein of unknown function (DUF422); Region: DUF422; cl00991 446462013169 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 446462013170 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446462013171 active site 446462013172 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 446462013173 Peptidase family M28; Region: Peptidase_M28; pfam04389 446462013174 active site 446462013175 metal binding site [ion binding]; metal-binding site 446462013176 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462013177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462013178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462013179 active site 446462013180 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462013181 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462013182 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462013183 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462013184 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462013185 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 446462013186 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446462013187 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462013188 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446462013189 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446462013190 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446462013191 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462013192 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462013193 putative sugar binding sites [chemical binding]; other site 446462013194 Q-X-W motif; other site 446462013195 putative pectinesterase; Region: PLN02432; cl01911 446462013196 Pectinesterase; Region: Pectinesterase; pfam01095 446462013197 Amb_all domain; Region: Amb_all; smart00656 446462013198 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 446462013199 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446462013200 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462013201 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462013202 putative sugar binding sites [chemical binding]; other site 446462013203 Q-X-W motif; other site 446462013204 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 446462013205 active site 446462013206 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462013207 HIGH motif; other site 446462013208 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446462013209 anticodon binding site; other site 446462013210 tRNA binding surface [nucleotide binding]; other site 446462013211 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462013212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462013213 S-adenosylmethionine binding site [chemical binding]; other site 446462013214 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 446462013215 hypothetical protein; Provisional; Region: PRK07236 446462013216 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462013217 Transport protein; Region: actII; TIGR00833 446462013218 MMPL family; Region: MMPL; pfam03176 446462013219 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462013220 MarR family; Region: MarR_2; cl17246 446462013221 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462013222 homodimer interface [polypeptide binding]; other site 446462013223 active site 446462013224 TDP-binding site; other site 446462013225 acceptor substrate-binding pocket; other site 446462013226 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446462013227 homodimer interface [polypeptide binding]; other site 446462013228 active site 446462013229 TDP-binding site; other site 446462013230 acceptor substrate-binding pocket; other site 446462013231 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446462013232 Domain of unknown function DUF21; Region: DUF21; pfam01595 446462013233 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446462013234 Transporter associated domain; Region: CorC_HlyC; smart01091 446462013235 TIR domain; Region: TIR_2; cl17458 446462013236 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462013237 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462013238 sequence-specific DNA binding site [nucleotide binding]; other site 446462013239 salt bridge; other site 446462013240 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 446462013241 Domain of unknown function (DUF385); Region: DUF385; pfam04075 446462013242 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 446462013243 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446462013244 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446462013245 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446462013246 active site 446462013247 catalytic triad [active] 446462013248 oxyanion hole [active] 446462013249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462013250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462013251 active site 446462013252 phosphorylation site [posttranslational modification] 446462013253 intermolecular recognition site; other site 446462013254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462013255 DNA binding residues [nucleotide binding] 446462013256 dimerization interface [polypeptide binding]; other site 446462013257 Histidine kinase; Region: HisKA_3; pfam07730 446462013258 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462013259 ATP binding site [chemical binding]; other site 446462013260 Mg2+ binding site [ion binding]; other site 446462013261 G-X-G motif; other site 446462013262 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446462013263 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462013264 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446462013265 E3 interaction surface; other site 446462013266 lipoyl attachment site [posttranslational modification]; other site 446462013267 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446462013268 e3 binding domain; Region: E3_binding; pfam02817 446462013269 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446462013270 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446462013271 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446462013272 alpha subunit interface [polypeptide binding]; other site 446462013273 TPP binding site [chemical binding]; other site 446462013274 heterodimer interface [polypeptide binding]; other site 446462013275 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446462013276 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446462013277 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446462013278 tetramer interface [polypeptide binding]; other site 446462013279 TPP-binding site [chemical binding]; other site 446462013280 heterodimer interface [polypeptide binding]; other site 446462013281 phosphorylation loop region [posttranslational modification] 446462013282 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462013283 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446462013284 putative DNA binding site [nucleotide binding]; other site 446462013285 putative Zn2+ binding site [ion binding]; other site 446462013286 AsnC family; Region: AsnC_trans_reg; pfam01037 446462013287 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 446462013288 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446462013289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462013290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013291 dimerization interface [polypeptide binding]; other site 446462013292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462013293 dimer interface [polypeptide binding]; other site 446462013294 phosphorylation site [posttranslational modification] 446462013295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462013296 ATP binding site [chemical binding]; other site 446462013297 Mg2+ binding site [ion binding]; other site 446462013298 G-X-G motif; other site 446462013299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462013300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462013301 active site 446462013302 phosphorylation site [posttranslational modification] 446462013303 intermolecular recognition site; other site 446462013304 dimerization interface [polypeptide binding]; other site 446462013305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462013306 DNA binding site [nucleotide binding] 446462013307 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 446462013308 substrate binding site [chemical binding]; other site 446462013309 amidase catalytic site [active] 446462013310 Zn binding residues [ion binding]; other site 446462013311 Homeodomain-like domain; Region: HTH_23; pfam13384 446462013312 Winged helix-turn helix; Region: HTH_29; pfam13551 446462013313 Homeodomain-like domain; Region: HTH_32; pfam13565 446462013314 DDE superfamily endonuclease; Region: DDE_3; pfam13358 446462013315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 446462013316 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462013317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462013318 metal binding site [ion binding]; metal-binding site 446462013319 active site 446462013320 I-site; other site 446462013321 Putative cyclase; Region: Cyclase; cl00814 446462013322 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 446462013323 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462013324 NAD(P) binding site [chemical binding]; other site 446462013325 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446462013326 active site 446462013327 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462013328 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462013329 ligand binding site [chemical binding]; other site 446462013330 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462013331 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462013332 ligand binding site [chemical binding]; other site 446462013333 flexible hinge region; other site 446462013334 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446462013335 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446462013336 substrate binding pocket [chemical binding]; other site 446462013337 chain length determination region; other site 446462013338 substrate-Mg2+ binding site; other site 446462013339 catalytic residues [active] 446462013340 aspartate-rich region 1; other site 446462013341 active site lid residues [active] 446462013342 aspartate-rich region 2; other site 446462013343 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446462013344 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446462013345 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446462013346 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446462013347 TPP-binding site; other site 446462013348 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446462013349 PYR/PP interface [polypeptide binding]; other site 446462013350 dimer interface [polypeptide binding]; other site 446462013351 TPP binding site [chemical binding]; other site 446462013352 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446462013353 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446462013354 Putative zinc-finger; Region: zf-HC2; pfam13490 446462013355 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 446462013356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462013357 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462013358 DNA binding residues [nucleotide binding] 446462013359 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 446462013360 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446462013361 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446462013362 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 446462013363 putative NAD(P) binding site [chemical binding]; other site 446462013364 putative substrate binding site [chemical binding]; other site 446462013365 catalytic Zn binding site [ion binding]; other site 446462013366 structural Zn binding site [ion binding]; other site 446462013367 dimer interface [polypeptide binding]; other site 446462013368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462013369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462013370 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 446462013371 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 446462013372 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462013373 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462013374 putative acyl-acceptor binding pocket; other site 446462013375 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446462013376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462013377 active site 446462013378 phosphorylation site [posttranslational modification] 446462013379 intermolecular recognition site; other site 446462013380 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462013381 CHASE3 domain; Region: CHASE3; pfam05227 446462013382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013383 dimerization interface [polypeptide binding]; other site 446462013384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462013385 dimer interface [polypeptide binding]; other site 446462013386 phosphorylation site [posttranslational modification] 446462013387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462013388 ATP binding site [chemical binding]; other site 446462013389 Mg2+ binding site [ion binding]; other site 446462013390 G-X-G motif; other site 446462013391 Response regulator receiver domain; Region: Response_reg; pfam00072 446462013392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462013393 active site 446462013394 phosphorylation site [posttranslational modification] 446462013395 intermolecular recognition site; other site 446462013396 dimerization interface [polypeptide binding]; other site 446462013397 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462013398 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462013399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462013400 non-specific DNA binding site [nucleotide binding]; other site 446462013401 salt bridge; other site 446462013402 sequence-specific DNA binding site [nucleotide binding]; other site 446462013403 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446462013404 Part of AAA domain; Region: AAA_19; pfam13245 446462013405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462013406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462013407 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446462013408 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 446462013409 NADP binding site [chemical binding]; other site 446462013410 active site 446462013411 steroid binding site; other site 446462013412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462013413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446462013414 NAD(P) binding site [chemical binding]; other site 446462013415 active site 446462013416 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 446462013417 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446462013418 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 446462013419 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446462013420 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462013421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462013422 Amidohydrolase; Region: Amidohydro_4; pfam13147 446462013423 active site 446462013424 Transposase domain (DUF772); Region: DUF772; pfam05598 446462013425 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462013426 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 446462013427 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446462013428 Part of AAA domain; Region: AAA_19; pfam13245 446462013429 Family description; Region: UvrD_C_2; pfam13538 446462013430 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462013431 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446462013432 Walker A/P-loop; other site 446462013433 ATP binding site [chemical binding]; other site 446462013434 Q-loop/lid; other site 446462013435 ABC transporter signature motif; other site 446462013436 Walker B; other site 446462013437 D-loop; other site 446462013438 H-loop/switch region; other site 446462013439 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446462013440 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462013441 ABC-ATPase subunit interface; other site 446462013442 dimer interface [polypeptide binding]; other site 446462013443 putative PBP binding regions; other site 446462013444 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446462013445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446462013446 ABC-ATPase subunit interface; other site 446462013447 dimer interface [polypeptide binding]; other site 446462013448 putative PBP binding regions; other site 446462013449 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462013450 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446462013451 substrate binding site [chemical binding]; other site 446462013452 ATP binding site [chemical binding]; other site 446462013453 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 446462013454 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 446462013455 putative NAD(P) binding site [chemical binding]; other site 446462013456 catalytic Zn binding site [ion binding]; other site 446462013457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462013458 metabolite-proton symporter; Region: 2A0106; TIGR00883 446462013459 putative substrate translocation pore; other site 446462013460 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 446462013461 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446462013462 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446462013463 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446462013464 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 446462013465 putative active site pocket [active] 446462013466 putative metal binding site [ion binding]; other site 446462013467 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446462013468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462013469 DNA-binding site [nucleotide binding]; DNA binding site 446462013470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 446462013471 Condensation domain; Region: Condensation; pfam00668 446462013472 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462013473 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446462013474 acyl-activating enzyme (AAE) consensus motif; other site 446462013475 AMP binding site [chemical binding]; other site 446462013476 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462013477 Condensation domain; Region: Condensation; pfam00668 446462013478 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462013479 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462013480 acyl-activating enzyme (AAE) consensus motif; other site 446462013481 AMP binding site [chemical binding]; other site 446462013482 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462013483 Condensation domain; Region: Condensation; pfam00668 446462013484 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462013485 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462013486 acyl-activating enzyme (AAE) consensus motif; other site 446462013487 AMP binding site [chemical binding]; other site 446462013488 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462013489 Condensation domain; Region: Condensation; pfam00668 446462013490 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462013491 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462013492 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446462013493 acyl-activating enzyme (AAE) consensus motif; other site 446462013494 AMP binding site [chemical binding]; other site 446462013495 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446462013496 Condensation domain; Region: Condensation; pfam00668 446462013497 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446462013498 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446462013499 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446462013500 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446462013501 siderophore binding site; other site 446462013502 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 446462013503 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462013504 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462013505 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 446462013506 Walker A/P-loop; other site 446462013507 ATP binding site [chemical binding]; other site 446462013508 Q-loop/lid; other site 446462013509 ABC transporter signature motif; other site 446462013510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462013511 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462013512 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446462013513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462013514 Walker A/P-loop; other site 446462013515 ATP binding site [chemical binding]; other site 446462013516 Q-loop/lid; other site 446462013517 ABC transporter signature motif; other site 446462013518 Walker B; other site 446462013519 D-loop; other site 446462013520 H-loop/switch region; other site 446462013521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446462013522 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446462013523 amidase catalytic site [active] 446462013524 Zn binding residues [ion binding]; other site 446462013525 substrate binding site [chemical binding]; other site 446462013526 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446462013527 Cellulose binding domain; Region: CBM_2; pfam00553 446462013528 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 446462013529 active site 446462013530 catalytic residues [active] 446462013531 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 446462013532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462013533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462013534 dimerization interface [polypeptide binding]; other site 446462013535 LysE type translocator; Region: LysE; cl00565 446462013536 RibD C-terminal domain; Region: RibD_C; cl17279 446462013537 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 446462013538 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446462013539 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462013540 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446462013541 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446462013542 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 446462013543 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 446462013544 active site 446462013545 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 446462013546 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 446462013547 active site 446462013548 Coenzyme A transferase; Region: CoA_trans; cl17247 446462013549 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 446462013550 Domain of unknown function DUF87; Region: DUF87; pfam01935 446462013551 AAA-like domain; Region: AAA_10; pfam12846 446462013552 Zonular occludens toxin (Zot); Region: Zot; cl17485 446462013553 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 446462013554 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446462013555 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446462013556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013557 dimerization interface [polypeptide binding]; other site 446462013558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013559 dimerization interface [polypeptide binding]; other site 446462013560 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446462013561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013562 dimerization interface [polypeptide binding]; other site 446462013563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013564 dimerization interface [polypeptide binding]; other site 446462013565 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446462013566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013567 dimerization interface [polypeptide binding]; other site 446462013568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013569 dimerization interface [polypeptide binding]; other site 446462013570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013571 dimerization interface [polypeptide binding]; other site 446462013572 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462013573 dimerization interface [polypeptide binding]; other site 446462013574 GAF domain; Region: GAF_2; pfam13185 446462013575 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462013576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462013577 dimer interface [polypeptide binding]; other site 446462013578 phosphorylation site [posttranslational modification] 446462013579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462013580 ATP binding site [chemical binding]; other site 446462013581 Mg2+ binding site [ion binding]; other site 446462013582 G-X-G motif; other site 446462013583 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446462013584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462013585 active site 446462013586 phosphorylation site [posttranslational modification] 446462013587 intermolecular recognition site; other site 446462013588 dimerization interface [polypeptide binding]; other site 446462013589 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462013590 anti sigma factor interaction site; other site 446462013591 regulatory phosphorylation site [posttranslational modification]; other site 446462013592 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462013593 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446462013594 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462013595 anti sigma factor interaction site; other site 446462013596 regulatory phosphorylation site [posttranslational modification]; other site 446462013597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462013598 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462013599 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 446462013600 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 446462013601 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462013602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462013603 DNA binding site [nucleotide binding] 446462013604 domain linker motif; other site 446462013605 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462013606 dimerization interface [polypeptide binding]; other site 446462013607 ligand binding site [chemical binding]; other site 446462013608 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 446462013609 dimer interface [polypeptide binding]; other site 446462013610 catalytic triad [active] 446462013611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462013612 NAD(P) binding site [chemical binding]; other site 446462013613 active site 446462013614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462013615 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446462013616 HEXXH motif domain; Region: mod_HExxH; TIGR04267 446462013617 CsbD-like; Region: CsbD; pfam05532 446462013618 ANTAR domain; Region: ANTAR; pfam03861 446462013619 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462013620 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 446462013621 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 446462013622 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 446462013623 catalytic site [active] 446462013624 active site 446462013625 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446462013626 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 446462013627 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 446462013628 active site 446462013629 catalytic site [active] 446462013630 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446462013631 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446462013632 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446462013633 active site 446462013634 catalytic site [active] 446462013635 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 446462013636 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462013637 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462013638 DNA binding site [nucleotide binding] 446462013639 domain linker motif; other site 446462013640 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462013641 ligand binding site [chemical binding]; other site 446462013642 dimerization interface [polypeptide binding]; other site 446462013643 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446462013644 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446462013645 catalytic triad [active] 446462013646 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 446462013647 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446462013648 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446462013649 Peptidase family M23; Region: Peptidase_M23; pfam01551 446462013650 Transglycosylase; Region: Transgly; pfam00912 446462013651 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446462013652 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446462013653 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462013654 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446462013655 substrate binding site [chemical binding]; other site 446462013656 ATP binding site [chemical binding]; other site 446462013657 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 446462013658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462013659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462013660 DNA binding residues [nucleotide binding] 446462013661 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462013662 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462013663 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 446462013664 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 446462013665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462013666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462013667 dimerization interface [polypeptide binding]; other site 446462013668 short chain dehydrogenase; Provisional; Region: PRK07454 446462013669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462013670 NAD(P) binding site [chemical binding]; other site 446462013671 active site 446462013672 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462013673 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446462013674 hypothetical protein; Provisional; Region: PRK02947 446462013675 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446462013676 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462013677 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462013678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462013679 Walker A/P-loop; other site 446462013680 ATP binding site [chemical binding]; other site 446462013681 Q-loop/lid; other site 446462013682 ABC transporter signature motif; other site 446462013683 Walker B; other site 446462013684 D-loop; other site 446462013685 H-loop/switch region; other site 446462013686 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462013687 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446462013688 substrate binding site [chemical binding]; other site 446462013689 oxyanion hole (OAH) forming residues; other site 446462013690 trimer interface [polypeptide binding]; other site 446462013691 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446462013692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462013693 Walker A/P-loop; other site 446462013694 ATP binding site [chemical binding]; other site 446462013695 Q-loop/lid; other site 446462013696 ABC transporter signature motif; other site 446462013697 Walker B; other site 446462013698 D-loop; other site 446462013699 H-loop/switch region; other site 446462013700 ABC transporter; Region: ABC_tran_2; pfam12848 446462013701 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446462013702 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446462013703 classical (c) SDRs; Region: SDR_c; cd05233 446462013704 NAD(P) binding site [chemical binding]; other site 446462013705 active site 446462013706 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462013707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462013708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462013709 DNA binding residues [nucleotide binding] 446462013710 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 446462013711 putative active site [active] 446462013712 putative catalytic triad [active] 446462013713 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 446462013714 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 446462013715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446462013716 Zn2+ binding site [ion binding]; other site 446462013717 Mg2+ binding site [ion binding]; other site 446462013718 MASE1; Region: MASE1; pfam05231 446462013719 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 446462013720 lycopene cyclase; Region: lycopene_cycl; TIGR01789 446462013721 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462013722 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446462013723 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462013724 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462013725 metal binding site [ion binding]; metal-binding site 446462013726 active site 446462013727 I-site; other site 446462013728 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446462013729 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446462013730 FOG: CBS domain [General function prediction only]; Region: COG0517 446462013731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 446462013732 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446462013733 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 446462013734 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 446462013735 trimerization site [polypeptide binding]; other site 446462013736 active site 446462013737 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446462013738 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 446462013739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462013740 catalytic residue [active] 446462013741 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 446462013742 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 446462013743 Walker A/P-loop; other site 446462013744 ATP binding site [chemical binding]; other site 446462013745 Q-loop/lid; other site 446462013746 ABC transporter signature motif; other site 446462013747 Walker B; other site 446462013748 D-loop; other site 446462013749 H-loop/switch region; other site 446462013750 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 446462013751 iron-sulfur cluster [ion binding]; other site 446462013752 [2Fe-2S] cluster binding site [ion binding]; other site 446462013753 FeS assembly protein SufD; Region: sufD; TIGR01981 446462013754 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 446462013755 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 446462013756 FeS assembly protein SufB; Region: sufB; TIGR01980 446462013757 Predicted transcriptional regulator [Transcription]; Region: COG2345 446462013758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462013759 putative DNA binding site [nucleotide binding]; other site 446462013760 putative Zn2+ binding site [ion binding]; other site 446462013761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462013762 NAD(P) binding site [chemical binding]; other site 446462013763 active site 446462013764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462013765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462013766 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 446462013767 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 446462013768 nucleophile elbow; other site 446462013769 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 446462013770 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462013771 putative ADP-binding pocket [chemical binding]; other site 446462013772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462013773 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446462013774 Walker A/P-loop; other site 446462013775 ATP binding site [chemical binding]; other site 446462013776 Q-loop/lid; other site 446462013777 ABC transporter signature motif; other site 446462013778 Walker B; other site 446462013779 D-loop; other site 446462013780 H-loop/switch region; other site 446462013781 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446462013782 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 446462013783 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 446462013784 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446462013785 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 446462013786 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 446462013787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462013788 putative DNA binding site [nucleotide binding]; other site 446462013789 putative Zn2+ binding site [ion binding]; other site 446462013790 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446462013791 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 446462013792 Nitrate and nitrite sensing; Region: NIT; pfam08376 446462013793 HAMP domain; Region: HAMP; pfam00672 446462013794 Protein of unknown function, DUF485; Region: DUF485; pfam04341 446462013795 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446462013796 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 446462013797 Na binding site [ion binding]; other site 446462013798 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462013799 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446462013800 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 446462013801 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 446462013802 NADP binding site [chemical binding]; other site 446462013803 dimer interface [polypeptide binding]; other site 446462013804 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446462013805 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 446462013806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462013807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462013808 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 446462013809 UbiA prenyltransferase family; Region: UbiA; pfam01040 446462013810 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 446462013811 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446462013812 TPP-binding site [chemical binding]; other site 446462013813 dimer interface [polypeptide binding]; other site 446462013814 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446462013815 PYR/PP interface [polypeptide binding]; other site 446462013816 dimer interface [polypeptide binding]; other site 446462013817 TPP binding site [chemical binding]; other site 446462013818 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446462013819 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 446462013820 putative active site [active] 446462013821 transaldolase; Provisional; Region: PRK03903 446462013822 catalytic residue [active] 446462013823 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 446462013824 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446462013825 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446462013826 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446462013827 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446462013828 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446462013829 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 446462013830 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 446462013831 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 446462013832 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 446462013833 putative active site [active] 446462013834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462013835 Histidine kinase; Region: HisKA_3; pfam07730 446462013836 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446462013837 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446462013838 triosephosphate isomerase; Provisional; Region: PRK14567 446462013839 substrate binding site [chemical binding]; other site 446462013840 dimer interface [polypeptide binding]; other site 446462013841 catalytic triad [active] 446462013842 Phosphoglycerate kinase; Region: PGK; pfam00162 446462013843 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 446462013844 substrate binding site [chemical binding]; other site 446462013845 hinge regions; other site 446462013846 ADP binding site [chemical binding]; other site 446462013847 catalytic site [active] 446462013848 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 446462013849 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 446462013850 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446462013851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 446462013852 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 446462013853 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 446462013854 dimer interface [polypeptide binding]; other site 446462013855 phosphate binding site [ion binding]; other site 446462013856 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 446462013857 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 446462013858 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446462013859 GIY-YIG motif/motif A; other site 446462013860 active site 446462013861 catalytic site [active] 446462013862 putative DNA binding site [nucleotide binding]; other site 446462013863 metal binding site [ion binding]; metal-binding site 446462013864 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 446462013865 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446462013866 iron-sulfur cluster [ion binding]; other site 446462013867 [2Fe-2S] cluster binding site [ion binding]; other site 446462013868 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446462013869 iron-sulfur cluster [ion binding]; other site 446462013870 [2Fe-2S] cluster binding site [ion binding]; other site 446462013871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462013872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462013873 sequence-specific DNA binding site [nucleotide binding]; other site 446462013874 salt bridge; other site 446462013875 WYL domain; Region: WYL; pfam13280 446462013876 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446462013877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462013878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462013879 DNA binding residues [nucleotide binding] 446462013880 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446462013881 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 446462013882 Peptidase family M28; Region: Peptidase_M28; pfam04389 446462013883 metal binding site [ion binding]; metal-binding site 446462013884 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446462013885 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 446462013886 homopentamer interface [polypeptide binding]; other site 446462013887 active site 446462013888 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 446462013889 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 446462013890 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446462013891 dimerization interface [polypeptide binding]; other site 446462013892 active site 446462013893 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 446462013894 Lumazine binding domain; Region: Lum_binding; pfam00677 446462013895 Lumazine binding domain; Region: Lum_binding; pfam00677 446462013896 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 446462013897 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 446462013898 substrate binding site [chemical binding]; other site 446462013899 hexamer interface [polypeptide binding]; other site 446462013900 metal binding site [ion binding]; metal-binding site 446462013901 Flavoprotein; Region: Flavoprotein; cl08021 446462013902 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 446462013903 putative RNA binding site [nucleotide binding]; other site 446462013904 16S rRNA methyltransferase B; Provisional; Region: PRK14902 446462013905 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 446462013906 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 446462013907 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 446462013908 putative active site [active] 446462013909 substrate binding site [chemical binding]; other site 446462013910 putative cosubstrate binding site; other site 446462013911 catalytic site [active] 446462013912 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446462013913 substrate binding site [chemical binding]; other site 446462013914 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446462013915 active site 446462013916 catalytic residues [active] 446462013917 metal binding site [ion binding]; metal-binding site 446462013918 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446462013919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462013920 phosphoglucomutase; Validated; Region: PRK07564 446462013921 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 446462013922 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 446462013923 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 446462013924 primosome assembly protein PriA; Provisional; Region: PRK14873 446462013925 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446462013926 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446462013927 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446462013928 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446462013929 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 446462013930 Flavoprotein; Region: Flavoprotein; pfam02441 446462013931 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 446462013932 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 446462013933 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 446462013934 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 446462013935 catalytic site [active] 446462013936 G-X2-G-X-G-K; other site 446462013937 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 446462013938 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 446462013939 active site 446462013940 dimer interface [polypeptide binding]; other site 446462013941 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 446462013942 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462013943 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462013944 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 446462013945 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462013946 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462013947 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 446462013948 IMP binding site; other site 446462013949 dimer interface [polypeptide binding]; other site 446462013950 interdomain contacts; other site 446462013951 partial ornithine binding site; other site 446462013952 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 446462013953 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 446462013954 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 446462013955 catalytic site [active] 446462013956 subunit interface [polypeptide binding]; other site 446462013957 dihydroorotase; Validated; Region: pyrC; PRK09357 446462013958 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462013959 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 446462013960 active site 446462013961 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 446462013962 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446462013963 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446462013964 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 446462013965 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 446462013966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462013967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462013968 non-specific DNA binding site [nucleotide binding]; other site 446462013969 salt bridge; other site 446462013970 sequence-specific DNA binding site [nucleotide binding]; other site 446462013971 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 446462013972 putative RNA binding site [nucleotide binding]; other site 446462013973 elongation factor P; Validated; Region: PRK00529 446462013974 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 446462013975 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 446462013976 RNA binding site [nucleotide binding]; other site 446462013977 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 446462013978 RNA binding site [nucleotide binding]; other site 446462013979 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 446462013980 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 446462013981 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 446462013982 active site 446462013983 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446462013984 Dehydroquinase class II; Region: DHquinase_II; pfam01220 446462013985 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 446462013986 trimer interface [polypeptide binding]; other site 446462013987 active site 446462013988 dimer interface [polypeptide binding]; other site 446462013989 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446462013990 active site 446462013991 dimer interface [polypeptide binding]; other site 446462013992 metal binding site [ion binding]; metal-binding site 446462013993 shikimate kinase; Reviewed; Region: aroK; PRK00131 446462013994 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 446462013995 magnesium binding site [ion binding]; other site 446462013996 putative shikimate binding site; other site 446462013997 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 446462013998 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 446462013999 Tetramer interface [polypeptide binding]; other site 446462014000 active site 446462014001 FMN-binding site [chemical binding]; other site 446462014002 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 446462014003 HPr interaction site; other site 446462014004 glycerol kinase (GK) interaction site [polypeptide binding]; other site 446462014005 active site 446462014006 phosphorylation site [posttranslational modification] 446462014007 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 446462014008 active site turn [active] 446462014009 phosphorylation site [posttranslational modification] 446462014010 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462014011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462014012 DNA-binding site [nucleotide binding]; DNA binding site 446462014013 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446462014014 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 446462014015 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 446462014016 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 446462014017 dimerization domain swap beta strand [polypeptide binding]; other site 446462014018 regulatory protein interface [polypeptide binding]; other site 446462014019 active site 446462014020 regulatory phosphorylation site [posttranslational modification]; other site 446462014021 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 446462014022 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446462014023 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 446462014024 shikimate binding site; other site 446462014025 NAD(P) binding site [chemical binding]; other site 446462014026 YceG-like family; Region: YceG; pfam02618 446462014027 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 446462014028 dimerization interface [polypeptide binding]; other site 446462014029 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 446462014030 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 446462014031 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 446462014032 motif 1; other site 446462014033 active site 446462014034 motif 2; other site 446462014035 motif 3; other site 446462014036 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 446462014037 DHHA1 domain; Region: DHHA1; pfam02272 446462014038 Cupin superfamily protein; Region: Cupin_4; pfam08007 446462014039 Cupin-like domain; Region: Cupin_8; pfam13621 446462014040 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462014041 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462014042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462014043 S-adenosylmethionine binding site [chemical binding]; other site 446462014044 recombination factor protein RarA; Reviewed; Region: PRK13342 446462014045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462014046 Walker A motif; other site 446462014047 ATP binding site [chemical binding]; other site 446462014048 Walker B motif; other site 446462014049 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 446462014050 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446462014051 active site 446462014052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462014053 ATP binding site [chemical binding]; other site 446462014054 putative Mg++ binding site [ion binding]; other site 446462014055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462014056 nucleotide binding region [chemical binding]; other site 446462014057 ATP-binding site [chemical binding]; other site 446462014058 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 446462014059 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462014060 DNA binding site [nucleotide binding] 446462014061 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462014062 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446462014063 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446462014064 catalytic residue [active] 446462014065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446462014066 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 446462014067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462014068 active site 446462014069 phosphorylation site [posttranslational modification] 446462014070 intermolecular recognition site; other site 446462014071 dimerization interface [polypeptide binding]; other site 446462014072 LytTr DNA-binding domain; Region: LytTR; smart00850 446462014073 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446462014074 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446462014075 Na binding site [ion binding]; other site 446462014076 GAF domain; Region: GAF_3; pfam13492 446462014077 Histidine kinase; Region: His_kinase; pfam06580 446462014078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462014079 ATP binding site [chemical binding]; other site 446462014080 Mg2+ binding site [ion binding]; other site 446462014081 G-X-G motif; other site 446462014082 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 446462014083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462014084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462014085 WHG domain; Region: WHG; pfam13305 446462014086 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 446462014087 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446462014088 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462014089 active site 446462014090 metal binding site [ion binding]; metal-binding site 446462014091 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 446462014092 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 446462014093 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446462014094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462014095 AAA domain; Region: AAA_21; pfam13304 446462014096 Walker A/P-loop; other site 446462014097 ATP binding site [chemical binding]; other site 446462014098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462014099 Walker B; other site 446462014100 D-loop; other site 446462014101 H-loop/switch region; other site 446462014102 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446462014103 active site 446462014104 metal binding site [ion binding]; metal-binding site 446462014105 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446462014106 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462014107 substrate binding site [chemical binding]; other site 446462014108 oxyanion hole (OAH) forming residues; other site 446462014109 trimer interface [polypeptide binding]; other site 446462014110 Predicted transcriptional regulators [Transcription]; Region: COG1733 446462014111 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446462014112 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446462014113 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 446462014114 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 446462014115 active site 446462014116 metal binding site [ion binding]; metal-binding site 446462014117 nudix motif; other site 446462014118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462014119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462014120 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 446462014121 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462014122 putative NAD(P) binding site [chemical binding]; other site 446462014123 Cupin; Region: Cupin_6; pfam12852 446462014124 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462014125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462014126 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446462014127 Immunity protein Imm1; Region: Imm1; pfam14430 446462014128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462014129 NAD(P) binding site [chemical binding]; other site 446462014130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462014131 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446462014132 active site 446462014133 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 446462014134 RNase_H superfamily; Region: RNase_H_2; pfam13482 446462014135 Part of AAA domain; Region: AAA_19; pfam13245 446462014136 AAA domain; Region: AAA_11; pfam13086 446462014137 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446462014138 AAA domain; Region: AAA_12; pfam13087 446462014139 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446462014140 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 446462014141 putative NAD(P) binding site [chemical binding]; other site 446462014142 catalytic Zn binding site [ion binding]; other site 446462014143 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446462014144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462014145 dimer interface [polypeptide binding]; other site 446462014146 conserved gate region; other site 446462014147 putative PBP binding loops; other site 446462014148 ABC-ATPase subunit interface; other site 446462014149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462014150 putative PBP binding loops; other site 446462014151 ABC-ATPase subunit interface; other site 446462014152 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446462014153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446462014154 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446462014155 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 446462014156 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446462014157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462014158 trimer interface [polypeptide binding]; other site 446462014159 oxyanion hole (OAH) forming residues; other site 446462014160 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446462014161 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446462014162 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446462014163 active site 446462014164 zinc binding site [ion binding]; other site 446462014165 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462014166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462014167 DNA binding residues [nucleotide binding] 446462014168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 446462014169 MOSC domain; Region: MOSC; pfam03473 446462014170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462014171 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462014172 active site 446462014173 catalytic tetrad [active] 446462014174 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 446462014175 putative active site [active] 446462014176 catalytic site [active] 446462014177 putative metal binding site [ion binding]; other site 446462014178 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 446462014179 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 446462014180 substrate binding site [chemical binding]; other site 446462014181 dimer interface [polypeptide binding]; other site 446462014182 NADP binding site [chemical binding]; other site 446462014183 catalytic residues [active] 446462014184 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446462014185 active site 2 [active] 446462014186 active site 1 [active] 446462014187 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 446462014188 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 446462014189 active site 446462014190 catalytic residues [active] 446462014191 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446462014192 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446462014193 putative sugar binding sites [chemical binding]; other site 446462014194 Q-X-W motif; other site 446462014195 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446462014196 DNA binding site [nucleotide binding] 446462014197 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462014198 NB-ARC domain; Region: NB-ARC; pfam00931 446462014199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462014200 Tetratricopeptide repeat; Region: TPR_1; pfam00515 446462014201 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462014202 PAC2 family; Region: PAC2; pfam09754 446462014203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462014204 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 446462014205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462014206 Walker A/P-loop; other site 446462014207 ATP binding site [chemical binding]; other site 446462014208 Q-loop/lid; other site 446462014209 ABC transporter signature motif; other site 446462014210 Walker B; other site 446462014211 D-loop; other site 446462014212 H-loop/switch region; other site 446462014213 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446462014214 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 446462014215 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446462014216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462014217 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 446462014218 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462014219 putative NAD(P) binding site [chemical binding]; other site 446462014220 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 446462014221 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 446462014222 probable active site [active] 446462014223 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446462014224 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446462014225 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 446462014226 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446462014227 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462014228 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 446462014229 aromatic chitin/cellulose binding site residues [chemical binding]; other site 446462014230 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 446462014231 putative sugar binding site [chemical binding]; other site 446462014232 catalytic residues [active] 446462014233 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462014234 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462014235 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462014236 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 446462014237 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 446462014238 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 446462014239 Cellulose binding domain; Region: CBM_2; pfam00553 446462014240 classical (c) SDRs; Region: SDR_c; cd05233 446462014241 NAD(P) binding site [chemical binding]; other site 446462014242 active site 446462014243 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446462014244 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446462014245 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462014246 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462014247 DNA binding site [nucleotide binding] 446462014248 domain linker motif; other site 446462014249 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462014250 dimerization interface [polypeptide binding]; other site 446462014251 ligand binding site [chemical binding]; other site 446462014252 Domain of unknown function DUF21; Region: DUF21; pfam01595 446462014253 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446462014254 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446462014255 Transporter associated domain; Region: CorC_HlyC; smart01091 446462014256 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446462014257 Domain of unknown function DUF21; Region: DUF21; pfam01595 446462014258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446462014259 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446462014260 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446462014261 metal ion-dependent adhesion site (MIDAS); other site 446462014262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462014263 putative DNA binding site [nucleotide binding]; other site 446462014264 putative Zn2+ binding site [ion binding]; other site 446462014265 H+ Antiporter protein; Region: 2A0121; TIGR00900 446462014266 glycine dehydrogenase; Provisional; Region: PRK05367 446462014267 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 446462014268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462014269 tetramer interface [polypeptide binding]; other site 446462014270 catalytic residue [active] 446462014271 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 446462014272 tetramer interface [polypeptide binding]; other site 446462014273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462014274 catalytic residue [active] 446462014275 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 446462014276 DNA binding residues [nucleotide binding] 446462014277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462014278 putative dimer interface [polypeptide binding]; other site 446462014279 Bifunctional nuclease; Region: DNase-RNase; pfam02577 446462014280 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446462014281 DNA binding residues [nucleotide binding] 446462014282 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446462014283 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446462014284 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446462014285 phosphopeptide binding site; other site 446462014286 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446462014287 lipoyl attachment site [posttranslational modification]; other site 446462014288 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446462014289 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462014290 anti sigma factor interaction site; other site 446462014291 regulatory phosphorylation site [posttranslational modification]; other site 446462014292 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462014293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446462014294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446462014295 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462014296 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 446462014297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462014298 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462014299 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462014300 DNA binding residues [nucleotide binding] 446462014301 Transcription factor WhiB; Region: Whib; pfam02467 446462014302 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 446462014303 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462014304 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462014305 active site 446462014306 catalytic tetrad [active] 446462014307 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 446462014308 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 446462014309 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462014310 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462014311 DNA binding residues [nucleotide binding] 446462014312 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 446462014313 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446462014314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462014315 FeS/SAM binding site; other site 446462014316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462014317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462014318 ATP binding site [chemical binding]; other site 446462014319 Mg2+ binding site [ion binding]; other site 446462014320 G-X-G motif; other site 446462014321 transcriptional regulator NarL; Provisional; Region: PRK10651 446462014322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462014323 active site 446462014324 phosphorylation site [posttranslational modification] 446462014325 intermolecular recognition site; other site 446462014326 dimerization interface [polypeptide binding]; other site 446462014327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462014328 DNA binding residues [nucleotide binding] 446462014329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462014330 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462014331 DNA binding residues [nucleotide binding] 446462014332 dimerization interface [polypeptide binding]; other site 446462014333 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446462014334 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446462014335 metal ion-dependent adhesion site (MIDAS); other site 446462014336 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 446462014337 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 446462014338 phage tail protein domain; Region: tail_TIGR02242 446462014339 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 446462014340 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 446462014341 PAAR motif; Region: PAAR_motif; cl15808 446462014342 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 446462014343 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 446462014344 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 446462014345 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 446462014346 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 446462014347 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 446462014348 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 446462014349 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 446462014350 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 446462014351 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462014352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462014353 Walker A motif; other site 446462014354 ATP binding site [chemical binding]; other site 446462014355 Walker B motif; other site 446462014356 arginine finger; other site 446462014357 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 446462014358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462014359 non-specific DNA binding site [nucleotide binding]; other site 446462014360 salt bridge; other site 446462014361 sequence-specific DNA binding site [nucleotide binding]; other site 446462014362 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462014363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446462014364 Walker A motif; other site 446462014365 ATP binding site [chemical binding]; other site 446462014366 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446462014367 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 446462014368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462014369 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462014370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462014371 DNA binding residues [nucleotide binding] 446462014372 eRF1 domain 3; Region: eRF1_3; pfam03465 446462014373 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446462014374 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446462014375 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446462014376 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462014377 anti sigma factor interaction site; other site 446462014378 regulatory phosphorylation site [posttranslational modification]; other site 446462014379 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 446462014380 conserved cys residue [active] 446462014381 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446462014382 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446462014383 conserved cys residue [active] 446462014384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462014385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462014386 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462014387 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462014388 active site 446462014389 ATP binding site [chemical binding]; other site 446462014390 substrate binding site [chemical binding]; other site 446462014391 activation loop (A-loop); other site 446462014392 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446462014393 nucleoside/Zn binding site; other site 446462014394 dimer interface [polypeptide binding]; other site 446462014395 catalytic motif [active] 446462014396 CHAT domain; Region: CHAT; cl17868 446462014397 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462014398 active site 446462014399 catalytic residues [active] 446462014400 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462014401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462014402 PAS domain; Region: PAS_9; pfam13426 446462014403 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462014404 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462014405 metal binding site [ion binding]; metal-binding site 446462014406 active site 446462014407 I-site; other site 446462014408 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446462014409 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446462014410 G2 box; other site 446462014411 Switch I region; other site 446462014412 G3 box; other site 446462014413 Switch II region; other site 446462014414 GTP/Mg2+ binding site [chemical binding]; other site 446462014415 G4 box; other site 446462014416 G5 box; other site 446462014417 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 446462014418 Nitrate and nitrite sensing; Region: NIT; pfam08376 446462014419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462014420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462014421 ATP binding site [chemical binding]; other site 446462014422 Mg2+ binding site [ion binding]; other site 446462014423 G-X-G motif; other site 446462014424 NMT1/THI5 like; Region: NMT1; pfam09084 446462014425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462014426 substrate binding pocket [chemical binding]; other site 446462014427 membrane-bound complex binding site; other site 446462014428 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 446462014429 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446462014430 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446462014431 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446462014432 Walker A/P-loop; other site 446462014433 ATP binding site [chemical binding]; other site 446462014434 Q-loop/lid; other site 446462014435 ABC transporter signature motif; other site 446462014436 Walker B; other site 446462014437 D-loop; other site 446462014438 H-loop/switch region; other site 446462014439 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446462014440 Zinc finger protein; Region: DUF3669; pfam12417 446462014441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462014442 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446462014443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462014444 dimer interface [polypeptide binding]; other site 446462014445 conserved gate region; other site 446462014446 putative PBP binding loops; other site 446462014447 ABC-ATPase subunit interface; other site 446462014448 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 446462014449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446462014450 RNA binding surface [nucleotide binding]; other site 446462014451 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 446462014452 active site 446462014453 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 446462014454 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 446462014455 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446462014456 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446462014457 P-loop; other site 446462014458 Magnesium ion binding site [ion binding]; other site 446462014459 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446462014460 Magnesium ion binding site [ion binding]; other site 446462014461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462014462 dimerization interface [polypeptide binding]; other site 446462014463 putative DNA binding site [nucleotide binding]; other site 446462014464 putative Zn2+ binding site [ion binding]; other site 446462014465 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 446462014466 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462014467 active site 446462014468 DNA binding site [nucleotide binding] 446462014469 Int/Topo IB signature motif; other site 446462014470 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446462014471 TM2 domain; Region: TM2; pfam05154 446462014472 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 446462014473 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446462014474 dimer interface [polypeptide binding]; other site 446462014475 active site 446462014476 ADP-ribose binding site [chemical binding]; other site 446462014477 nudix motif; other site 446462014478 metal binding site [ion binding]; metal-binding site 446462014479 CTP synthetase; Validated; Region: pyrG; PRK05380 446462014480 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 446462014481 Catalytic site [active] 446462014482 active site 446462014483 UTP binding site [chemical binding]; other site 446462014484 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 446462014485 active site 446462014486 putative oxyanion hole; other site 446462014487 catalytic triad [active] 446462014488 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 446462014489 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 446462014490 Thiamine pyrophosphokinase; Region: TPK; cl08415 446462014491 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 446462014492 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 446462014493 Walker A/P-loop; other site 446462014494 ATP binding site [chemical binding]; other site 446462014495 Q-loop/lid; other site 446462014496 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 446462014497 ABC transporter signature motif; other site 446462014498 Walker B; other site 446462014499 D-loop; other site 446462014500 H-loop/switch region; other site 446462014501 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 446462014502 ATP-NAD kinase; Region: NAD_kinase; pfam01513 446462014503 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 446462014504 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446462014505 RNA binding surface [nucleotide binding]; other site 446462014506 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 446462014507 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 446462014508 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 446462014509 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446462014510 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446462014511 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 446462014512 active site 446462014513 HIGH motif; other site 446462014514 dimer interface [polypeptide binding]; other site 446462014515 KMSKS motif; other site 446462014516 S4 RNA-binding domain; Region: S4; smart00363 446462014517 RNA binding surface [nucleotide binding]; other site 446462014518 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 446462014519 Ca2+ binding site [ion binding]; other site 446462014520 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 446462014521 Ca2+ binding site [ion binding]; other site 446462014522 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 446462014523 active site 446462014524 DNA binding site [nucleotide binding] 446462014525 argininosuccinate lyase; Provisional; Region: PRK00855 446462014526 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 446462014527 active sites [active] 446462014528 tetramer interface [polypeptide binding]; other site 446462014529 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 446462014530 arginine repressor; Provisional; Region: PRK03341 446462014531 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 446462014532 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 446462014533 ornithine carbamoyltransferase; Provisional; Region: PRK00779 446462014534 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446462014535 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446462014536 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 446462014537 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462014538 inhibitor-cofactor binding pocket; inhibition site 446462014539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462014540 catalytic residue [active] 446462014541 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 446462014542 feedback inhibition sensing region; other site 446462014543 homohexameric interface [polypeptide binding]; other site 446462014544 nucleotide binding site [chemical binding]; other site 446462014545 N-acetyl-L-glutamate binding site [chemical binding]; other site 446462014546 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 446462014547 heterotetramer interface [polypeptide binding]; other site 446462014548 active site pocket [active] 446462014549 cleavage site 446462014550 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 446462014551 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446462014552 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 446462014553 putative NAD(P) binding site [chemical binding]; other site 446462014554 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462014555 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 446462014556 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462014557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462014558 non-specific DNA binding site [nucleotide binding]; other site 446462014559 salt bridge; other site 446462014560 sequence-specific DNA binding site [nucleotide binding]; other site 446462014561 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 446462014562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462014563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462014564 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446462014565 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 446462014566 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 446462014567 putative tRNA-binding site [nucleotide binding]; other site 446462014568 B3/4 domain; Region: B3_4; pfam03483 446462014569 tRNA synthetase B5 domain; Region: B5; smart00874 446462014570 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 446462014571 dimer interface [polypeptide binding]; other site 446462014572 motif 1; other site 446462014573 motif 3; other site 446462014574 motif 2; other site 446462014575 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 446462014576 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 446462014577 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 446462014578 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 446462014579 dimer interface [polypeptide binding]; other site 446462014580 motif 1; other site 446462014581 active site 446462014582 motif 2; other site 446462014583 motif 3; other site 446462014584 HSP90 family protein; Provisional; Region: PRK14083 446462014585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462014586 Mg2+ binding site [ion binding]; other site 446462014587 G-X-G motif; other site 446462014588 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 446462014589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462014590 active site 446462014591 phosphorylation site [posttranslational modification] 446462014592 intermolecular recognition site; other site 446462014593 dimerization interface [polypeptide binding]; other site 446462014594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462014595 DNA binding site [nucleotide binding] 446462014596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462014597 HAMP domain; Region: HAMP; pfam00672 446462014598 dimerization interface [polypeptide binding]; other site 446462014599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462014600 dimer interface [polypeptide binding]; other site 446462014601 phosphorylation site [posttranslational modification] 446462014602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462014603 ATP binding site [chemical binding]; other site 446462014604 Mg2+ binding site [ion binding]; other site 446462014605 G-X-G motif; other site 446462014606 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446462014607 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 446462014608 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446462014609 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 446462014610 23S rRNA binding site [nucleotide binding]; other site 446462014611 L21 binding site [polypeptide binding]; other site 446462014612 L13 binding site [polypeptide binding]; other site 446462014613 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 446462014614 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 446462014615 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 446462014616 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 446462014617 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462014618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462014619 non-specific DNA binding site [nucleotide binding]; other site 446462014620 salt bridge; other site 446462014621 sequence-specific DNA binding site [nucleotide binding]; other site 446462014622 AAA ATPase domain; Region: AAA_16; pfam13191 446462014623 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462014624 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446462014625 homotrimer interaction site [polypeptide binding]; other site 446462014626 putative active site [active] 446462014627 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462014628 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446462014629 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462014630 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462014631 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446462014632 substrate binding site [chemical binding]; other site 446462014633 ATP binding site [chemical binding]; other site 446462014634 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 446462014635 dimer interface [polypeptide binding]; other site 446462014636 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446462014637 active site 446462014638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462014639 substrate binding site [chemical binding]; other site 446462014640 catalytic residue [active] 446462014641 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 446462014642 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 446462014643 active site 446462014644 putative substrate binding pocket [chemical binding]; other site 446462014645 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462014646 GntP family permease; Region: GntP_permease; pfam02447 446462014647 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446462014648 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 446462014649 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446462014650 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446462014651 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 446462014652 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 446462014653 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462014654 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446462014655 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446462014656 aspartate aminotransferase; Provisional; Region: PRK05764 446462014657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462014658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462014659 homodimer interface [polypeptide binding]; other site 446462014660 catalytic residue [active] 446462014661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462014662 dimerization interface [polypeptide binding]; other site 446462014663 putative DNA binding site [nucleotide binding]; other site 446462014664 putative Zn2+ binding site [ion binding]; other site 446462014665 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 446462014666 putative hydrophobic ligand binding site [chemical binding]; other site 446462014667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462014668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462014669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462014670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462014671 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446462014672 Domain of unknown function (DUF309); Region: DUF309; pfam03745 446462014673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462014674 Coenzyme A binding pocket [chemical binding]; other site 446462014675 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462014676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462014677 salt bridge; other site 446462014678 non-specific DNA binding site [nucleotide binding]; other site 446462014679 sequence-specific DNA binding site [nucleotide binding]; other site 446462014680 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 446462014681 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446462014682 cleavage site 446462014683 active site 446462014684 substrate binding sites [chemical binding]; other site 446462014685 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446462014686 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 446462014687 RES domain; Region: RES; pfam08808 446462014688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462014689 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462014690 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462014691 ligand binding site [chemical binding]; other site 446462014692 flexible hinge region; other site 446462014693 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446462014694 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446462014695 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462014696 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 446462014697 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462014698 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 446462014699 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462014700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462014701 Walker A/P-loop; other site 446462014702 ATP binding site [chemical binding]; other site 446462014703 Q-loop/lid; other site 446462014704 ABC transporter signature motif; other site 446462014705 Walker B; other site 446462014706 D-loop; other site 446462014707 H-loop/switch region; other site 446462014708 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446462014709 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446462014710 excinuclease ABC subunit B; Provisional; Region: PRK05298 446462014711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462014712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462014713 nucleotide binding region [chemical binding]; other site 446462014714 ATP-binding site [chemical binding]; other site 446462014715 Ultra-violet resistance protein B; Region: UvrB; pfam12344 446462014716 UvrB/uvrC motif; Region: UVR; pfam02151 446462014717 Protein of unknown function (DUF402); Region: DUF402; cl00979 446462014718 Protein of unknown function (DUF402); Region: DUF402; cl00979 446462014719 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 446462014720 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 446462014721 CoA-binding site [chemical binding]; other site 446462014722 ATP-binding [chemical binding]; other site 446462014723 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 446462014724 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 446462014725 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 446462014726 RNA binding site [nucleotide binding]; other site 446462014727 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 446462014728 RNA binding site [nucleotide binding]; other site 446462014729 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446462014730 RNA binding site [nucleotide binding]; other site 446462014731 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 446462014732 RNA binding site [nucleotide binding]; other site 446462014733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462014734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462014735 S-adenosylmethionine binding site [chemical binding]; other site 446462014736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462014737 Coenzyme A binding pocket [chemical binding]; other site 446462014738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462014739 Walker A/P-loop; other site 446462014740 ATP binding site [chemical binding]; other site 446462014741 Q-loop/lid; other site 446462014742 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446462014743 Predicted membrane protein [Function unknown]; Region: COG1511 446462014744 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 446462014745 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 446462014746 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462014747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462014748 short chain dehydrogenase; Provisional; Region: PRK08309 446462014749 AAA domain; Region: AAA_17; pfam13207 446462014750 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462014751 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462014752 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462014753 DNA polymerase I; Provisional; Region: PRK05755 446462014754 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446462014755 active site 446462014756 metal binding site 1 [ion binding]; metal-binding site 446462014757 putative 5' ssDNA interaction site; other site 446462014758 metal binding site 3; metal-binding site 446462014759 metal binding site 2 [ion binding]; metal-binding site 446462014760 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446462014761 putative DNA binding site [nucleotide binding]; other site 446462014762 putative metal binding site [ion binding]; other site 446462014763 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 446462014764 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 446462014765 active site 446462014766 DNA binding site [nucleotide binding] 446462014767 catalytic site [active] 446462014768 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446462014769 CoenzymeA binding site [chemical binding]; other site 446462014770 subunit interaction site [polypeptide binding]; other site 446462014771 PHB binding site; other site 446462014772 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446462014773 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446462014774 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446462014775 Walker A/P-loop; other site 446462014776 ATP binding site [chemical binding]; other site 446462014777 Q-loop/lid; other site 446462014778 ABC transporter signature motif; other site 446462014779 Walker B; other site 446462014780 D-loop; other site 446462014781 H-loop/switch region; other site 446462014782 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446462014783 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446462014784 Walker A/P-loop; other site 446462014785 ATP binding site [chemical binding]; other site 446462014786 Q-loop/lid; other site 446462014787 ABC transporter signature motif; other site 446462014788 Walker B; other site 446462014789 D-loop; other site 446462014790 H-loop/switch region; other site 446462014791 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446462014792 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446462014793 TM-ABC transporter signature motif; other site 446462014794 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462014795 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446462014796 TM-ABC transporter signature motif; other site 446462014797 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446462014798 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 446462014799 dimerization interface [polypeptide binding]; other site 446462014800 ligand binding site [chemical binding]; other site 446462014801 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 446462014802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462014803 active site 446462014804 phosphorylation site [posttranslational modification] 446462014805 intermolecular recognition site; other site 446462014806 dimerization interface [polypeptide binding]; other site 446462014807 ANTAR domain; Region: ANTAR; pfam03861 446462014808 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446462014809 DinB superfamily; Region: DinB_2; pfam12867 446462014810 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 446462014811 putative active site [active] 446462014812 catalytic site [active] 446462014813 CoA binding domain; Region: CoA_binding; cl17356 446462014814 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 446462014815 homotrimer interaction site [polypeptide binding]; other site 446462014816 putative active site [active] 446462014817 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446462014818 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446462014819 catalytic site [active] 446462014820 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446462014821 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 446462014822 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446462014823 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446462014824 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 446462014825 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462014826 ATP binding site [chemical binding]; other site 446462014827 putative Mg++ binding site [ion binding]; other site 446462014828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462014829 nucleotide binding region [chemical binding]; other site 446462014830 ATP-binding site [chemical binding]; other site 446462014831 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 446462014832 HRDC domain; Region: HRDC; pfam00570 446462014833 HNH endonuclease; Region: HNH_2; pfam13391 446462014834 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446462014835 active site 446462014836 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446462014837 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462014838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462014839 non-specific DNA binding site [nucleotide binding]; other site 446462014840 salt bridge; other site 446462014841 sequence-specific DNA binding site [nucleotide binding]; other site 446462014842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462014843 non-specific DNA binding site [nucleotide binding]; other site 446462014844 salt bridge; other site 446462014845 sequence-specific DNA binding site [nucleotide binding]; other site 446462014846 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 446462014847 active site 446462014848 DNA Polymerase alpha zinc finger; Region: zf-DNA_Pol; pfam08996 446462014849 AAA domain; Region: AAA_33; pfam13671 446462014850 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446462014851 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446462014852 cofactor binding site; other site 446462014853 DNA binding site [nucleotide binding] 446462014854 substrate interaction site [chemical binding]; other site 446462014855 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446462014856 Transcription factor WhiB; Region: Whib; pfam02467 446462014857 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 446462014858 DNA protecting protein DprA; Region: dprA; TIGR00732 446462014859 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 446462014860 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 446462014861 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 446462014862 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 446462014863 nudix motif; other site 446462014864 Helix-turn-helix domain; Region: HTH_17; cl17695 446462014865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462014866 DNA-binding site [nucleotide binding]; DNA binding site 446462014867 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446462014868 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446462014869 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 446462014870 active site 446462014871 oxyanion hole [active] 446462014872 catalytic triad [active] 446462014873 hypothetical protein; Region: PHA02451 446462014874 Phage Terminase; Region: Terminase_1; pfam03354 446462014875 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 446462014876 Protein of unknown function (DUF464); Region: DUF464; cl01080 446462014877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462014878 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 446462014879 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 446462014880 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446462014881 active site 446462014882 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462014883 active site 446462014884 DNA binding site [nucleotide binding] 446462014885 Int/Topo IB signature motif; other site 446462014886 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446462014887 putative homotetramer interface [polypeptide binding]; other site 446462014888 putative homodimer interface [polypeptide binding]; other site 446462014889 putative allosteric switch controlling residues; other site 446462014890 putative metal binding site [ion binding]; other site 446462014891 Lsr2; Region: Lsr2; pfam11774 446462014892 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446462014893 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446462014894 glutamine binding [chemical binding]; other site 446462014895 catalytic triad [active] 446462014896 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 446462014897 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446462014898 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446462014899 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 446462014900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462014901 DNA binding residues [nucleotide binding] 446462014902 phosphodiesterase YaeI; Provisional; Region: PRK11340 446462014903 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446462014904 putative active site [active] 446462014905 putative metal binding site [ion binding]; other site 446462014906 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 446462014907 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 446462014908 dimer interface [polypeptide binding]; other site 446462014909 active site 446462014910 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462014911 catalytic residues [active] 446462014912 substrate binding site [chemical binding]; other site 446462014913 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 446462014914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462014915 S-adenosylmethionine binding site [chemical binding]; other site 446462014916 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 446462014917 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446462014918 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446462014919 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 446462014920 putative FMN binding site [chemical binding]; other site 446462014921 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 446462014922 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 446462014923 dimer interface [polypeptide binding]; other site 446462014924 active site 446462014925 glycine-pyridoxal phosphate binding site [chemical binding]; other site 446462014926 folate binding site [chemical binding]; other site 446462014927 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 446462014928 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446462014929 integral membrane protein; Region: integ_memb_HG; TIGR03954 446462014930 Glucitol operon activator protein (GutM); Region: GutM; cl01890 446462014931 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446462014932 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446462014933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462014934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462014935 active site 446462014936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462014937 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 446462014938 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446462014939 dimer interface [polypeptide binding]; other site 446462014940 active site 446462014941 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 446462014942 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462014943 substrate binding site [chemical binding]; other site 446462014944 oxyanion hole (OAH) forming residues; other site 446462014945 trimer interface [polypeptide binding]; other site 446462014946 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446462014947 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462014948 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446462014949 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 446462014950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446462014951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446462014952 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 446462014953 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462014954 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462014955 DNA binding site [nucleotide binding] 446462014956 domain linker motif; other site 446462014957 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 446462014958 putative dimerization interface [polypeptide binding]; other site 446462014959 putative ligand binding site [chemical binding]; other site 446462014960 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446462014961 FtsX-like permease family; Region: FtsX; pfam02687 446462014962 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446462014963 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 446462014964 FtsX-like permease family; Region: FtsX; pfam02687 446462014965 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462014966 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462014967 Walker A/P-loop; other site 446462014968 ATP binding site [chemical binding]; other site 446462014969 Q-loop/lid; other site 446462014970 ABC transporter signature motif; other site 446462014971 Walker B; other site 446462014972 D-loop; other site 446462014973 H-loop/switch region; other site 446462014974 AAA ATPase domain; Region: AAA_16; pfam13191 446462014975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462014976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462014977 DNA binding residues [nucleotide binding] 446462014978 dimerization interface [polypeptide binding]; other site 446462014979 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462014980 DNA binding site [nucleotide binding] 446462014981 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462014982 NB-ARC domain; Region: NB-ARC; pfam00931 446462014983 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462014984 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462014985 binding surface 446462014986 TPR motif; other site 446462014987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462014988 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446462014989 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446462014990 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462014991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462014992 non-specific DNA binding site [nucleotide binding]; other site 446462014993 sequence-specific DNA binding site [nucleotide binding]; other site 446462014994 salt bridge; other site 446462014995 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446462014996 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446462014997 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446462014998 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 446462014999 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 446462015000 active site clefts [active] 446462015001 zinc binding site [ion binding]; other site 446462015002 dimer interface [polypeptide binding]; other site 446462015003 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446462015004 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 446462015005 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 446462015006 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462015007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462015008 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 446462015009 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462015010 tyrosine decarboxylase; Region: PLN02880 446462015011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462015012 catalytic residue [active] 446462015013 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 446462015014 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 446462015015 active site 446462015016 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 446462015017 catalytic triad [active] 446462015018 dimer interface [polypeptide binding]; other site 446462015019 pyruvate kinase; Provisional; Region: PRK06247 446462015020 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 446462015021 domain interfaces; other site 446462015022 active site 446462015023 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 446462015024 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 446462015025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462015026 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 446462015027 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 446462015028 active site 446462015029 dimer interface [polypeptide binding]; other site 446462015030 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 446462015031 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 446462015032 active site 446462015033 FMN binding site [chemical binding]; other site 446462015034 substrate binding site [chemical binding]; other site 446462015035 3Fe-4S cluster binding site [ion binding]; other site 446462015036 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 446462015037 domain interface; other site 446462015038 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 446462015039 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446462015040 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 446462015041 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 446462015042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462015043 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462015044 dimerization interface [polypeptide binding]; other site 446462015045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462015046 dimer interface [polypeptide binding]; other site 446462015047 phosphorylation site [posttranslational modification] 446462015048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462015049 ATP binding site [chemical binding]; other site 446462015050 Mg2+ binding site [ion binding]; other site 446462015051 G-X-G motif; other site 446462015052 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462015053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462015054 active site 446462015055 phosphorylation site [posttranslational modification] 446462015056 intermolecular recognition site; other site 446462015057 dimerization interface [polypeptide binding]; other site 446462015058 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462015059 DNA binding site [nucleotide binding] 446462015060 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 446462015061 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 446462015062 substrate binding site [chemical binding]; other site 446462015063 active site 446462015064 catalytic residues [active] 446462015065 heterodimer interface [polypeptide binding]; other site 446462015066 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 446462015067 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 446462015068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462015069 catalytic residue [active] 446462015070 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 446462015071 active site 446462015072 ribulose/triose binding site [chemical binding]; other site 446462015073 phosphate binding site [ion binding]; other site 446462015074 substrate (anthranilate) binding pocket [chemical binding]; other site 446462015075 product (indole) binding pocket [chemical binding]; other site 446462015076 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 446462015077 anthranilate synthase component I; Provisional; Region: PRK13571 446462015078 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446462015079 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446462015080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462015081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462015082 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 446462015083 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 446462015084 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446462015085 substrate binding site [chemical binding]; other site 446462015086 glutamase interaction surface [polypeptide binding]; other site 446462015087 Fic/DOC family; Region: Fic; cl00960 446462015088 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 446462015089 Clp amino terminal domain; Region: Clp_N; pfam02861 446462015090 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 446462015091 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446462015092 catalytic residues [active] 446462015093 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 446462015094 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 446462015095 putative active site [active] 446462015096 oxyanion strand; other site 446462015097 catalytic triad [active] 446462015098 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 446462015099 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446462015100 PYR/PP interface [polypeptide binding]; other site 446462015101 dimer interface [polypeptide binding]; other site 446462015102 TPP binding site [chemical binding]; other site 446462015103 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446462015104 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446462015105 TPP-binding site [chemical binding]; other site 446462015106 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462015107 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 446462015108 DNA binding residues [nucleotide binding] 446462015109 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 446462015110 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 446462015111 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 446462015112 putative active site pocket [active] 446462015113 4-fold oligomerization interface [polypeptide binding]; other site 446462015114 metal binding residues [ion binding]; metal-binding site 446462015115 3-fold/trimer interface [polypeptide binding]; other site 446462015116 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 446462015117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462015118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462015119 homodimer interface [polypeptide binding]; other site 446462015120 catalytic residue [active] 446462015121 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 446462015122 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 446462015123 NAD binding site [chemical binding]; other site 446462015124 dimerization interface [polypeptide binding]; other site 446462015125 product binding site; other site 446462015126 substrate binding site [chemical binding]; other site 446462015127 zinc binding site [ion binding]; other site 446462015128 catalytic residues [active] 446462015129 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 446462015130 putative active site [active] 446462015131 Zn binding site [ion binding]; other site 446462015132 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446462015133 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462015134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462015135 catalytic residue [active] 446462015136 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446462015137 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 446462015138 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446462015139 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446462015140 active site 446462015141 catalytic triad [active] 446462015142 dimer interface [polypeptide binding]; other site 446462015143 PRC-barrel domain; Region: PRC; pfam05239 446462015144 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 446462015145 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 446462015146 dimerization interface [polypeptide binding]; other site 446462015147 active site 446462015148 L-aspartate oxidase; Provisional; Region: PRK07804 446462015149 L-aspartate oxidase; Provisional; Region: PRK06175 446462015150 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446462015151 quinolinate synthetase; Provisional; Region: PRK09375 446462015152 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 446462015153 nudix motif; other site 446462015154 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 446462015155 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 446462015156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462015157 benzoate transport; Region: 2A0115; TIGR00895 446462015158 putative substrate translocation pore; other site 446462015159 hypothetical protein; Provisional; Region: PRK05463 446462015160 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 446462015161 biotin synthase; Validated; Region: PRK06256 446462015162 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462015163 FeS/SAM binding site; other site 446462015164 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 446462015165 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 446462015166 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446462015167 catalytic residues [active] 446462015168 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 446462015169 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462015170 inhibitor-cofactor binding pocket; inhibition site 446462015171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462015172 catalytic residue [active] 446462015173 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 446462015174 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 446462015175 active site 446462015176 PHP Thumb interface [polypeptide binding]; other site 446462015177 metal binding site [ion binding]; metal-binding site 446462015178 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446462015179 generic binding surface II; other site 446462015180 generic binding surface I; other site 446462015181 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 446462015182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462015183 putative substrate translocation pore; other site 446462015184 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 446462015185 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 446462015186 active site 446462015187 lipoprotein signal peptidase; Provisional; Region: PRK14764 446462015188 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446462015189 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462015190 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462015191 catalytic residue [active] 446462015192 potassium/proton antiporter; Reviewed; Region: PRK05326 446462015193 TrkA-C domain; Region: TrkA_C; pfam02080 446462015194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446462015195 Coenzyme A binding pocket [chemical binding]; other site 446462015196 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 446462015197 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 446462015198 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446462015199 HIGH motif; other site 446462015200 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446462015201 active site 446462015202 KMSKS motif; other site 446462015203 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 446462015204 tRNA binding surface [nucleotide binding]; other site 446462015205 anticodon binding site; other site 446462015206 DivIVA domain; Region: DivI1A_domain; TIGR03544 446462015207 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 446462015208 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 446462015209 YGGT family; Region: YGGT; cl00508 446462015210 Protein of unknown function (DUF552); Region: DUF552; cl00775 446462015211 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 446462015212 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462015213 catalytic residue [active] 446462015214 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 446462015215 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 446462015216 cell division protein FtsZ; Validated; Region: PRK09330 446462015217 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 446462015218 nucleotide binding site [chemical binding]; other site 446462015219 SulA interaction site; other site 446462015220 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 446462015221 Cell division protein FtsQ; Region: FtsQ; pfam03799 446462015222 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 446462015223 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446462015224 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446462015225 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446462015226 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 446462015227 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 446462015228 active site 446462015229 homodimer interface [polypeptide binding]; other site 446462015230 cell division protein FtsW; Region: ftsW; TIGR02614 446462015231 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 446462015232 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 446462015233 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00141 446462015234 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446462015235 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 446462015236 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446462015237 Mg++ binding site [ion binding]; other site 446462015238 putative catalytic motif [active] 446462015239 putative substrate binding site [chemical binding]; other site 446462015240 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446462015241 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446462015242 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446462015243 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446462015244 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446462015245 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446462015246 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446462015247 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446462015248 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446462015249 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446462015250 MraW methylase family; Region: Methyltransf_5; cl17771 446462015251 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 446462015252 cell division protein MraZ; Reviewed; Region: PRK00326 446462015253 MraZ protein; Region: MraZ; pfam02381 446462015254 MraZ protein; Region: MraZ; pfam02381 446462015255 MoxR-like ATPases [General function prediction only]; Region: COG0714 446462015256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462015257 ATP binding site [chemical binding]; other site 446462015258 Walker A motif; other site 446462015259 Walker B motif; other site 446462015260 arginine finger; other site 446462015261 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446462015262 Protein of unknown function DUF58; Region: DUF58; pfam01882 446462015263 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446462015264 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446462015265 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446462015266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462015267 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462015268 ligand binding site [chemical binding]; other site 446462015269 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446462015270 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446462015271 active site 446462015272 DNA polymerase IV; Validated; Region: PRK02406 446462015273 DNA binding site [nucleotide binding] 446462015274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462015275 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446462015276 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446462015277 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462015278 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462015279 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462015280 DNA binding residues [nucleotide binding] 446462015281 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462015282 Methyltransferase domain; Region: Methyltransf_18; pfam12847 446462015283 S-adenosylmethionine binding site [chemical binding]; other site 446462015284 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446462015285 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 446462015286 P-loop; other site 446462015287 Magnesium ion binding site [ion binding]; other site 446462015288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446462015289 Magnesium ion binding site [ion binding]; other site 446462015290 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446462015291 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 446462015292 putative DNA binding site [nucleotide binding]; other site 446462015293 catalytic residue [active] 446462015294 putative H2TH interface [polypeptide binding]; other site 446462015295 putative catalytic residues [active] 446462015296 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446462015297 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446462015298 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 446462015299 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 446462015300 quinone interaction residues [chemical binding]; other site 446462015301 active site 446462015302 catalytic residues [active] 446462015303 FMN binding site [chemical binding]; other site 446462015304 substrate binding site [chemical binding]; other site 446462015305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462015306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462015307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462015308 NAD(P) binding site [chemical binding]; other site 446462015309 active site 446462015310 Permease family; Region: Xan_ur_permease; pfam00860 446462015311 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 446462015312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462015313 non-specific DNA binding site [nucleotide binding]; other site 446462015314 salt bridge; other site 446462015315 sequence-specific DNA binding site [nucleotide binding]; other site 446462015316 Competence-damaged protein; Region: CinA; pfam02464 446462015317 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 446462015318 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 446462015319 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446462015320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462015321 FeS/SAM binding site; other site 446462015322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462015323 Coenzyme A binding pocket [chemical binding]; other site 446462015324 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462015325 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462015326 DNA binding residues [nucleotide binding] 446462015327 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 446462015328 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446462015329 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462015330 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 446462015331 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462015332 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462015333 putative acyl-acceptor binding pocket; other site 446462015334 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446462015335 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446462015336 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446462015337 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 446462015338 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446462015339 dimer interface [polypeptide binding]; other site 446462015340 active site 446462015341 catalytic residue [active] 446462015342 TIGR03085 family protein; Region: TIGR03085 446462015343 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462015344 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462015345 active site 446462015346 ATP binding site [chemical binding]; other site 446462015347 substrate binding site [chemical binding]; other site 446462015348 activation loop (A-loop); other site 446462015349 Septum formation; Region: Septum_form; pfam13845 446462015350 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 446462015351 HicB family; Region: HicB; pfam05534 446462015352 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446462015353 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446462015354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462015355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462015356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462015357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462015358 active site 446462015359 catalytic tetrad [active] 446462015360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 446462015361 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446462015362 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446462015363 dihydrodipicolinate reductase; Provisional; Region: PRK00048 446462015364 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 446462015365 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 446462015366 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446462015367 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446462015368 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446462015369 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 446462015370 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 446462015371 oligomer interface [polypeptide binding]; other site 446462015372 RNA binding site [nucleotide binding]; other site 446462015373 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 446462015374 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 446462015375 RNase E interface [polypeptide binding]; other site 446462015376 trimer interface [polypeptide binding]; other site 446462015377 active site 446462015378 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 446462015379 putative nucleic acid binding region [nucleotide binding]; other site 446462015380 G-X-X-G motif; other site 446462015381 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 446462015382 RNA binding site [nucleotide binding]; other site 446462015383 domain interface; other site 446462015384 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 446462015385 16S/18S rRNA binding site [nucleotide binding]; other site 446462015386 S13e-L30e interaction site [polypeptide binding]; other site 446462015387 25S rRNA binding site [nucleotide binding]; other site 446462015388 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 446462015389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462015390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462015391 non-specific DNA binding site [nucleotide binding]; other site 446462015392 salt bridge; other site 446462015393 sequence-specific DNA binding site [nucleotide binding]; other site 446462015394 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 446462015395 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 446462015396 active site 446462015397 Riboflavin kinase; Region: Flavokinase; pfam01687 446462015398 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 446462015399 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 446462015400 RNA binding site [nucleotide binding]; other site 446462015401 active site 446462015402 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 446462015403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462015404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462015405 putative substrate translocation pore; other site 446462015406 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 446462015407 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 446462015408 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 446462015409 DHH family; Region: DHH; pfam01368 446462015410 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 446462015411 Protein of unknown function (DUF503); Region: DUF503; pfam04456 446462015412 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446462015413 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446462015414 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 446462015415 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 446462015416 G1 box; other site 446462015417 putative GEF interaction site [polypeptide binding]; other site 446462015418 GTP/Mg2+ binding site [chemical binding]; other site 446462015419 Switch I region; other site 446462015420 G2 box; other site 446462015421 G3 box; other site 446462015422 Switch II region; other site 446462015423 G4 box; other site 446462015424 G5 box; other site 446462015425 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 446462015426 Translation-initiation factor 2; Region: IF-2; pfam11987 446462015427 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 446462015428 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 446462015429 NusA N-terminal domain; Region: NusA_N; pfam08529 446462015430 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 446462015431 RNA binding site [nucleotide binding]; other site 446462015432 homodimer interface [polypeptide binding]; other site 446462015433 NusA-like KH domain; Region: KH_5; pfam13184 446462015434 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 446462015435 G-X-X-G motif; other site 446462015436 ribosome maturation protein RimP; Reviewed; Region: PRK00092 446462015437 Sm and related proteins; Region: Sm_like; cl00259 446462015438 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 446462015439 putative oligomer interface [polypeptide binding]; other site 446462015440 putative RNA binding site [nucleotide binding]; other site 446462015441 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 446462015442 dinuclear metal binding motif [ion binding]; other site 446462015443 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446462015444 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462015445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462015446 catalytic residue [active] 446462015447 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 446462015448 classical (c) SDRs; Region: SDR_c; cd05233 446462015449 NAD(P) binding site [chemical binding]; other site 446462015450 active site 446462015451 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 446462015452 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446462015453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462015454 motif II; other site 446462015455 prolyl-tRNA synthetase; Provisional; Region: PRK09194 446462015456 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 446462015457 dimer interface [polypeptide binding]; other site 446462015458 motif 1; other site 446462015459 active site 446462015460 motif 2; other site 446462015461 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 446462015462 putative deacylase active site [active] 446462015463 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446462015464 active site 446462015465 motif 3; other site 446462015466 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 446462015467 anticodon binding site; other site 446462015468 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446462015469 active site 446462015470 hypothetical protein; Validated; Region: PRK02101 446462015471 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462015472 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462015473 ligand binding site [chemical binding]; other site 446462015474 flexible hinge region; other site 446462015475 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446462015476 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462015477 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462015478 ligand binding site [chemical binding]; other site 446462015479 flexible hinge region; other site 446462015480 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446462015481 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 446462015482 ATP binding site [chemical binding]; other site 446462015483 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446462015484 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446462015485 ATP binding site [chemical binding]; other site 446462015486 Mg++ binding site [ion binding]; other site 446462015487 motif III; other site 446462015488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462015489 nucleotide binding region [chemical binding]; other site 446462015490 ATP-binding site [chemical binding]; other site 446462015491 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 446462015492 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 446462015493 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 446462015494 homodimer interface [polypeptide binding]; other site 446462015495 active site 446462015496 SAM binding site [chemical binding]; other site 446462015497 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446462015498 cleavage site 446462015499 active site 446462015500 substrate binding sites [chemical binding]; other site 446462015501 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 446462015502 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 446462015503 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 446462015504 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 446462015505 active site 446462015506 homodimer interface [polypeptide binding]; other site 446462015507 SAM binding site [chemical binding]; other site 446462015508 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 446462015509 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446462015510 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 446462015511 catalytic triad [active] 446462015512 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 446462015513 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 446462015514 homodimer interface [polypeptide binding]; other site 446462015515 Walker A motif; other site 446462015516 ATP binding site [chemical binding]; other site 446462015517 hydroxycobalamin binding site [chemical binding]; other site 446462015518 Walker B motif; other site 446462015519 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 446462015520 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446462015521 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 446462015522 metal ion-dependent adhesion site (MIDAS); other site 446462015523 short chain dehydrogenase; Provisional; Region: PRK06197 446462015524 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446462015525 putative NAD(P) binding site [chemical binding]; other site 446462015526 active site 446462015527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462015528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462015529 WHG domain; Region: WHG; pfam13305 446462015530 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 446462015531 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 446462015532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462015533 catalytic residue [active] 446462015534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462015535 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446462015536 active site 446462015537 substrate binding sites [chemical binding]; other site 446462015538 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446462015539 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446462015540 cleavage site 446462015541 active site 446462015542 substrate binding sites [chemical binding]; other site 446462015543 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446462015544 cleavage site 446462015545 active site 446462015546 substrate binding sites [chemical binding]; other site 446462015547 Peptidase family M48; Region: Peptidase_M48; cl12018 446462015548 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446462015549 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462015550 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446462015551 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 446462015552 trimer interface [polypeptide binding]; other site 446462015553 active site 446462015554 substrate binding site [chemical binding]; other site 446462015555 CoA binding site [chemical binding]; other site 446462015556 ATP-dependent protease La; Region: lon; TIGR00763 446462015557 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 446462015558 ATP binding site [chemical binding]; other site 446462015559 Walker B motif; other site 446462015560 arginine finger; other site 446462015561 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 446462015562 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446462015563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462015564 S-adenosylmethionine binding site [chemical binding]; other site 446462015565 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 446462015566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 446462015567 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 446462015568 NodB motif; other site 446462015569 active site 446462015570 catalytic site [active] 446462015571 metal binding site [ion binding]; metal-binding site 446462015572 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446462015573 substrate binding site [chemical binding]; other site 446462015574 mycothione reductase; Reviewed; Region: PRK07846 446462015575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462015576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462015577 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446462015578 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446462015579 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446462015580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462015581 DNA-binding site [nucleotide binding]; DNA binding site 446462015582 FCD domain; Region: FCD; pfam07729 446462015583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462015584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462015585 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446462015586 putative dimerization interface [polypeptide binding]; other site 446462015587 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 446462015588 EamA-like transporter family; Region: EamA; pfam00892 446462015589 cobyric acid synthase; Provisional; Region: PRK00784 446462015590 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 446462015591 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 446462015592 catalytic triad [active] 446462015593 methionine aminopeptidase; Provisional; Region: PRK12318 446462015594 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446462015595 active site 446462015596 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 446462015597 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446462015598 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446462015599 Predicted acetyltransferase [General function prediction only]; Region: COG3393 446462015600 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 446462015601 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446462015602 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446462015603 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446462015604 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 446462015605 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 446462015606 active site 446462015607 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 446462015608 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 446462015609 putative substrate binding region [chemical binding]; other site 446462015610 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 446462015611 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 446462015612 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 446462015613 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 446462015614 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 446462015615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462015616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462015617 active site 446462015618 phosphorylation site [posttranslational modification] 446462015619 intermolecular recognition site; other site 446462015620 dimerization interface [polypeptide binding]; other site 446462015621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462015622 DNA binding residues [nucleotide binding] 446462015623 dimerization interface [polypeptide binding]; other site 446462015624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462015625 Histidine kinase; Region: HisKA_3; pfam07730 446462015626 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462015627 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446462015628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446462015629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462015630 dimer interface [polypeptide binding]; other site 446462015631 conserved gate region; other site 446462015632 putative PBP binding loops; other site 446462015633 ABC-ATPase subunit interface; other site 446462015634 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 446462015635 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446462015636 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446462015637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462015638 Walker A/P-loop; other site 446462015639 ATP binding site [chemical binding]; other site 446462015640 Q-loop/lid; other site 446462015641 ABC transporter signature motif; other site 446462015642 Walker B; other site 446462015643 D-loop; other site 446462015644 H-loop/switch region; other site 446462015645 TOBE domain; Region: TOBE_2; pfam08402 446462015646 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 446462015647 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446462015648 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462015649 active site 446462015650 ATP binding site [chemical binding]; other site 446462015651 substrate binding site [chemical binding]; other site 446462015652 activation loop (A-loop); other site 446462015653 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 446462015654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462015655 FeS/SAM binding site; other site 446462015656 Predicted transcriptional regulators [Transcription]; Region: COG1695 446462015657 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446462015658 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462015659 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462015660 active site 446462015661 catalytic tetrad [active] 446462015662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462015663 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446462015664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462015665 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446462015666 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 446462015667 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 446462015668 ribosome recycling factor; Reviewed; Region: frr; PRK00083 446462015669 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 446462015670 hinge region; other site 446462015671 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 446462015672 putative nucleotide binding site [chemical binding]; other site 446462015673 uridine monophosphate binding site [chemical binding]; other site 446462015674 homohexameric interface [polypeptide binding]; other site 446462015675 elongation factor Ts; Provisional; Region: tsf; PRK09377 446462015676 UBA/TS-N domain; Region: UBA; pfam00627 446462015677 Elongation factor TS; Region: EF_TS; pfam00889 446462015678 Elongation factor TS; Region: EF_TS; pfam00889 446462015679 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 446462015680 rRNA interaction site [nucleotide binding]; other site 446462015681 S8 interaction site; other site 446462015682 putative laminin-1 binding site; other site 446462015683 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446462015684 Peptidase family M23; Region: Peptidase_M23; pfam01551 446462015685 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 446462015686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462015687 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446462015688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462015689 DNA binding residues [nucleotide binding] 446462015690 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446462015691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462015692 active site 446462015693 DNA binding site [nucleotide binding] 446462015694 Int/Topo IB signature motif; other site 446462015695 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446462015696 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446462015697 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446462015698 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 446462015699 hypothetical protein; Reviewed; Region: PRK12497 446462015700 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 446462015701 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 446462015702 RNA/DNA hybrid binding site [nucleotide binding]; other site 446462015703 active site 446462015704 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446462015705 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446462015706 Catalytic site [active] 446462015707 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446462015708 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446462015709 Catalytic site [active] 446462015710 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 446462015711 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 446462015712 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 446462015713 RimM N-terminal domain; Region: RimM; pfam01782 446462015714 PRC-barrel domain; Region: PRC; pfam05239 446462015715 hypothetical protein; Provisional; Region: PRK02821 446462015716 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 446462015717 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 446462015718 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 446462015719 putative active site [active] 446462015720 CAAX protease self-immunity; Region: Abi; pfam02517 446462015721 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446462015722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462015723 active site 446462015724 signal recognition particle protein; Provisional; Region: PRK10867 446462015725 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 446462015726 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 446462015727 P loop; other site 446462015728 GTP binding site [chemical binding]; other site 446462015729 Signal peptide binding domain; Region: SRP_SPB; pfam02978 446462015730 AAA domain; Region: AAA_33; pfam13671 446462015731 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446462015732 active site 446462015733 PII uridylyl-transferase; Provisional; Region: PRK03381 446462015734 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446462015735 metal binding triad; other site 446462015736 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446462015737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 446462015738 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 446462015739 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 446462015740 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 446462015741 Nitrogen regulatory protein P-II; Region: P-II; smart00938 446462015742 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 446462015743 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462015744 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462015745 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462015746 allantoicase; Provisional; Region: PRK13257 446462015747 Allantoicase repeat; Region: Allantoicase; pfam03561 446462015748 Allantoicase repeat; Region: Allantoicase; pfam03561 446462015749 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462015750 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462015751 allantoinase; Region: allantoinase; TIGR03178 446462015752 active site 446462015753 putative OHCU decarboxylase; Provisional; Region: PRK13798 446462015754 urate oxidase; Region: urate_oxi; TIGR03383 446462015755 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446462015756 active site 446462015757 Immunity protein Imm1; Region: Imm1; pfam14430 446462015758 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 446462015759 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446462015760 malate synthase A; Region: malate_syn_A; TIGR01344 446462015761 active site 446462015762 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446462015763 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462015764 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462015765 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 446462015766 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 446462015767 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446462015768 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 446462015769 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 446462015770 Na binding site [ion binding]; other site 446462015771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462015772 Coenzyme A binding pocket [chemical binding]; other site 446462015773 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446462015774 TIGR03086 family protein; Region: TIGR03086 446462015775 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462015776 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462015777 putative acyl-acceptor binding pocket; other site 446462015778 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 446462015779 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446462015780 Walker A/P-loop; other site 446462015781 ATP binding site [chemical binding]; other site 446462015782 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 446462015783 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446462015784 ABC transporter signature motif; other site 446462015785 Walker B; other site 446462015786 D-loop; other site 446462015787 H-loop/switch region; other site 446462015788 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 446462015789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462015790 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462015791 DNA binding residues [nucleotide binding] 446462015792 acylphosphatase; Provisional; Region: PRK14422 446462015793 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 446462015794 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446462015795 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446462015796 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 446462015797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462015798 active site 446462015799 phosphorylation site [posttranslational modification] 446462015800 intermolecular recognition site; other site 446462015801 dimerization interface [polypeptide binding]; other site 446462015802 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462015803 DNA binding site [nucleotide binding] 446462015804 MarR family; Region: MarR; pfam01047 446462015805 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446462015806 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 446462015807 DNA binding site [nucleotide binding] 446462015808 catalytic residue [active] 446462015809 H2TH interface [polypeptide binding]; other site 446462015810 putative catalytic residues [active] 446462015811 turnover-facilitating residue; other site 446462015812 intercalation triad [nucleotide binding]; other site 446462015813 8OG recognition residue [nucleotide binding]; other site 446462015814 putative reading head residues; other site 446462015815 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446462015816 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446462015817 ribonuclease III; Reviewed; Region: rnc; PRK00102 446462015818 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 446462015819 dimerization interface [polypeptide binding]; other site 446462015820 active site 446462015821 metal binding site [ion binding]; metal-binding site 446462015822 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 446462015823 dsRNA binding site [nucleotide binding]; other site 446462015824 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 446462015825 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 446462015826 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 446462015827 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 446462015828 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 446462015829 active site 446462015830 (T/H)XGH motif; other site 446462015831 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 446462015832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462015833 S-adenosylmethionine binding site [chemical binding]; other site 446462015834 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446462015835 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 446462015836 Immunity protein Imm1; Region: Imm1; pfam14430 446462015837 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446462015838 pyruvate carboxylase; Reviewed; Region: PRK12999 446462015839 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462015840 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462015841 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446462015842 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 446462015843 active site 446462015844 catalytic residues [active] 446462015845 metal binding site [ion binding]; metal-binding site 446462015846 homodimer binding site [polypeptide binding]; other site 446462015847 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446462015848 carboxyltransferase (CT) interaction site; other site 446462015849 biotinylation site [posttranslational modification]; other site 446462015850 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 446462015851 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446462015852 generic binding surface II; other site 446462015853 ssDNA binding site; other site 446462015854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446462015855 ATP binding site [chemical binding]; other site 446462015856 putative Mg++ binding site [ion binding]; other site 446462015857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446462015858 nucleotide binding region [chemical binding]; other site 446462015859 ATP-binding site [chemical binding]; other site 446462015860 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 446462015861 DAK2 domain; Region: Dak2; pfam02734 446462015862 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446462015863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462015864 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462015865 NAD(P) binding site [chemical binding]; other site 446462015866 active site 446462015867 MarR family; Region: MarR; pfam01047 446462015868 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 446462015869 ligand binding site [chemical binding]; other site 446462015870 active site 446462015871 UGI interface [polypeptide binding]; other site 446462015872 catalytic site [active] 446462015873 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 446462015874 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 446462015875 trimer interface [polypeptide binding]; other site 446462015876 putative metal binding site [ion binding]; other site 446462015877 thiamine monophosphate kinase; Provisional; Region: PRK05731 446462015878 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 446462015879 ATP binding site [chemical binding]; other site 446462015880 dimerization interface [polypeptide binding]; other site 446462015881 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462015882 AsnC family; Region: AsnC_trans_reg; pfam01037 446462015883 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 446462015884 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446462015885 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446462015886 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 446462015887 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 446462015888 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 446462015889 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446462015890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462015891 DNA-binding site [nucleotide binding]; DNA binding site 446462015892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462015893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462015894 homodimer interface [polypeptide binding]; other site 446462015895 catalytic residue [active] 446462015896 Immunity protein Imm1; Region: Imm1; pfam14430 446462015897 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462015898 cystathionine gamma-lyase; Validated; Region: PRK07582 446462015899 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462015900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462015901 catalytic residue [active] 446462015902 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446462015903 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 446462015904 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446462015905 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462015906 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462015907 putative acyl-acceptor binding pocket; other site 446462015908 Guanylyl transferase CofC like; Region: CofC; cl17472 446462015909 polyphosphate kinase; Provisional; Region: PRK05443 446462015910 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 446462015911 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 446462015912 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 446462015913 putative domain interface [polypeptide binding]; other site 446462015914 putative active site [active] 446462015915 catalytic site [active] 446462015916 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 446462015917 putative domain interface [polypeptide binding]; other site 446462015918 putative active site [active] 446462015919 catalytic site [active] 446462015920 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446462015921 active site 446462015922 Ap6A binding site [chemical binding]; other site 446462015923 nudix motif; other site 446462015924 metal binding site [ion binding]; metal-binding site 446462015925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462015926 catalytic core [active] 446462015927 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 446462015928 IHF - DNA interface [nucleotide binding]; other site 446462015929 IHF dimer interface [polypeptide binding]; other site 446462015930 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 446462015931 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 446462015932 substrate binding site [chemical binding]; other site 446462015933 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 446462015934 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 446462015935 substrate binding site [chemical binding]; other site 446462015936 ligand binding site [chemical binding]; other site 446462015937 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446462015938 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462015939 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462015940 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446462015941 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462015942 motif II; other site 446462015943 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 446462015944 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446462015945 HIGH motif; other site 446462015946 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446462015947 active site 446462015948 KMSKS motif; other site 446462015949 hypothetical protein; Provisional; Region: PRK06185 446462015950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462015951 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 446462015952 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446462015953 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446462015954 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 446462015955 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 446462015956 active site 446462015957 catalytic residues [active] 446462015958 metal binding site [ion binding]; metal-binding site 446462015959 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446462015960 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 446462015961 tartrate dehydrogenase; Region: TTC; TIGR02089 446462015962 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 446462015963 putative active site [active] 446462015964 catalytic triad [active] 446462015965 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 446462015966 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 446462015967 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 446462015968 ligand binding site [chemical binding]; other site 446462015969 NAD binding site [chemical binding]; other site 446462015970 dimerization interface [polypeptide binding]; other site 446462015971 catalytic site [active] 446462015972 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 446462015973 putative L-serine binding site [chemical binding]; other site 446462015974 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462015975 ketol-acid reductoisomerase; Provisional; Region: PRK05479 446462015976 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 446462015977 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 446462015978 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 446462015979 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 446462015980 putative valine binding site [chemical binding]; other site 446462015981 dimer interface [polypeptide binding]; other site 446462015982 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 446462015983 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 446462015984 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446462015985 PYR/PP interface [polypeptide binding]; other site 446462015986 dimer interface [polypeptide binding]; other site 446462015987 TPP binding site [chemical binding]; other site 446462015988 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446462015989 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 446462015990 TPP-binding site [chemical binding]; other site 446462015991 dimer interface [polypeptide binding]; other site 446462015992 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446462015993 Vitamin K epoxide reductase family in archaea and some bacteria; Region: VKOR_arc; cd12918 446462015994 putative active site [active] 446462015995 redox center [active] 446462015996 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 446462015997 DoxX; Region: DoxX; pfam07681 446462015998 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 446462015999 putative ligand binding site [chemical binding]; other site 446462016000 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446462016001 putative NAD binding site [chemical binding]; other site 446462016002 catalytic site [active] 446462016003 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462016004 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446462016005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462016006 TPR motif; other site 446462016007 binding surface 446462016008 CHAT domain; Region: CHAT; pfam12770 446462016009 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 446462016010 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 446462016011 GatB domain; Region: GatB_Yqey; smart00845 446462016012 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446462016013 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 446462016014 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 446462016015 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 446462016016 Uncharacterized conserved protein [Function unknown]; Region: COG4715 446462016017 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 446462016018 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 446462016019 nucleotide binding pocket [chemical binding]; other site 446462016020 K-X-D-G motif; other site 446462016021 catalytic site [active] 446462016022 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446462016023 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 446462016024 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446462016025 Dimer interface [polypeptide binding]; other site 446462016026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462016027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462016028 dimerization interface [polypeptide binding]; other site 446462016029 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 446462016030 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 446462016031 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 446462016032 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 446462016033 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 446462016034 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 446462016035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462016036 catalytic residue [active] 446462016037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462016038 putative substrate translocation pore; other site 446462016039 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462016040 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446462016041 putative acyl-acceptor binding pocket; other site 446462016042 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 446462016043 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 446462016044 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 446462016045 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 446462016046 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 446462016047 Ligand binding site [chemical binding]; other site 446462016048 Electron transfer flavoprotein domain; Region: ETF; pfam01012 446462016049 EDD domain protein, DegV family; Region: DegV; TIGR00762 446462016050 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 446462016051 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446462016052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462016053 S-adenosylmethionine binding site [chemical binding]; other site 446462016054 Uncharacterized conserved protein [Function unknown]; Region: COG1543 446462016055 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 446462016056 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 446462016057 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446462016058 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462016059 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 446462016060 active site 446462016061 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446462016062 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 446462016063 trimer interface [polypeptide binding]; other site 446462016064 active site 446462016065 substrate binding site [chemical binding]; other site 446462016066 CoA binding site [chemical binding]; other site 446462016067 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 446462016068 active site 446462016069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462016070 S-adenosylmethionine binding site [chemical binding]; other site 446462016071 ubiquinone biosynthesis methyltransferase; Region: PLN02232 446462016072 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462016073 enoyl-CoA hydratase; Provisional; Region: PRK05862 446462016074 substrate binding site [chemical binding]; other site 446462016075 oxyanion hole (OAH) forming residues; other site 446462016076 trimer interface [polypeptide binding]; other site 446462016077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446462016078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462016079 Walker A/P-loop; other site 446462016080 ATP binding site [chemical binding]; other site 446462016081 Q-loop/lid; other site 446462016082 ABC transporter signature motif; other site 446462016083 Walker B; other site 446462016084 D-loop; other site 446462016085 H-loop/switch region; other site 446462016086 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446462016087 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446462016088 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446462016089 active site 446462016090 catalytic site [active] 446462016091 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 446462016092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446462016093 active site residue [active] 446462016094 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 446462016095 putative homodimer interface [polypeptide binding]; other site 446462016096 putative active site pocket [active] 446462016097 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 446462016098 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 446462016099 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 446462016100 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446462016101 active site 446462016102 catalytic site [active] 446462016103 trehalose synthase; Region: treS_nterm; TIGR02456 446462016104 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 446462016105 active site 446462016106 catalytic site [active] 446462016107 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 446462016108 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 446462016109 glycogen branching enzyme; Provisional; Region: PRK05402 446462016110 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 446462016111 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 446462016112 active site 446462016113 catalytic site [active] 446462016114 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 446462016115 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446462016116 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446462016117 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 446462016118 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462016119 Domain of unknown function DUF77; Region: DUF77; pfam01910 446462016120 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446462016121 MarR family; Region: MarR_2; pfam12802 446462016122 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462016123 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446462016124 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462016125 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446462016126 Walker A/P-loop; other site 446462016127 ATP binding site [chemical binding]; other site 446462016128 Q-loop/lid; other site 446462016129 ABC transporter signature motif; other site 446462016130 Walker B; other site 446462016131 D-loop; other site 446462016132 H-loop/switch region; other site 446462016133 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 446462016134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 446462016135 DDE superfamily endonuclease; Region: DDE_4; pfam13359 446462016136 chaperone protein SicP; Provisional; Region: PRK15329 446462016137 lac repressor; Reviewed; Region: lacI; PRK09526 446462016138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462016139 DNA binding site [nucleotide binding] 446462016140 domain linker motif; other site 446462016141 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462016142 dimerization interface [polypeptide binding]; other site 446462016143 ligand binding site [chemical binding]; other site 446462016144 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446462016145 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462016146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462016147 Walker A/P-loop; other site 446462016148 ATP binding site [chemical binding]; other site 446462016149 Q-loop/lid; other site 446462016150 ABC transporter signature motif; other site 446462016151 Walker B; other site 446462016152 D-loop; other site 446462016153 H-loop/switch region; other site 446462016154 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462016155 TM-ABC transporter signature motif; other site 446462016156 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 446462016157 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446462016158 putative ligand binding site [chemical binding]; other site 446462016159 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462016160 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462016161 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462016162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462016163 active site 446462016164 phosphorylation site [posttranslational modification] 446462016165 intermolecular recognition site; other site 446462016166 dimerization interface [polypeptide binding]; other site 446462016167 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462016168 DNA binding residues [nucleotide binding] 446462016169 dimerization interface [polypeptide binding]; other site 446462016170 GAF domain; Region: GAF_2; pfam13185 446462016171 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462016172 Histidine kinase; Region: HisKA_3; pfam07730 446462016173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462016174 ATP binding site [chemical binding]; other site 446462016175 Mg2+ binding site [ion binding]; other site 446462016176 G-X-G motif; other site 446462016177 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 446462016178 N-acetyltransferase; Region: Acetyltransf_2; cl00949 446462016179 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446462016180 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 446462016181 dimer interface [polypeptide binding]; other site 446462016182 active site 446462016183 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 446462016184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446462016185 dimer interface [polypeptide binding]; other site 446462016186 substrate binding site [chemical binding]; other site 446462016187 metal binding site [ion binding]; metal-binding site 446462016188 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 446462016189 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446462016190 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446462016191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462016192 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 446462016193 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 446462016194 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446462016195 regulatory protein interface [polypeptide binding]; other site 446462016196 active site 446462016197 regulatory phosphorylation site [posttranslational modification]; other site 446462016198 DAK2 domain; Region: Dak2; cl03685 446462016199 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 446462016200 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 446462016201 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446462016202 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 446462016203 NAD(P) binding site [chemical binding]; other site 446462016204 catalytic residues [active] 446462016205 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 446462016206 Na binding site [ion binding]; other site 446462016207 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 446462016208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462016209 non-specific DNA binding site [nucleotide binding]; other site 446462016210 sequence-specific DNA binding site [nucleotide binding]; other site 446462016211 salt bridge; other site 446462016212 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462016213 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 446462016214 hypothetical protein; Provisional; Region: PRK03298 446462016215 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 446462016216 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446462016217 dimer interface [polypeptide binding]; other site 446462016218 ADP-ribose binding site [chemical binding]; other site 446462016219 active site 446462016220 nudix motif; other site 446462016221 metal binding site [ion binding]; metal-binding site 446462016222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462016223 enoyl-CoA hydratase; Validated; Region: PRK08139 446462016224 substrate binding site [chemical binding]; other site 446462016225 oxyanion hole (OAH) forming residues; other site 446462016226 trimer interface [polypeptide binding]; other site 446462016227 Isochorismatase family; Region: Isochorismatase; pfam00857 446462016228 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 446462016229 catalytic triad [active] 446462016230 conserved cis-peptide bond; other site 446462016231 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 446462016232 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446462016233 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446462016234 hinge; other site 446462016235 active site 446462016236 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 446462016237 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 446462016238 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 446462016239 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 446462016240 gamma subunit interface [polypeptide binding]; other site 446462016241 epsilon subunit interface [polypeptide binding]; other site 446462016242 LBP interface [polypeptide binding]; other site 446462016243 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 446462016244 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446462016245 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 446462016246 alpha subunit interaction interface [polypeptide binding]; other site 446462016247 Walker A motif; other site 446462016248 ATP binding site [chemical binding]; other site 446462016249 Walker B motif; other site 446462016250 inhibitor binding site; inhibition site 446462016251 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446462016252 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 446462016253 core domain interface [polypeptide binding]; other site 446462016254 delta subunit interface [polypeptide binding]; other site 446462016255 epsilon subunit interface [polypeptide binding]; other site 446462016256 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 446462016257 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446462016258 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 446462016259 beta subunit interaction interface [polypeptide binding]; other site 446462016260 Walker A motif; other site 446462016261 ATP binding site [chemical binding]; other site 446462016262 Walker B motif; other site 446462016263 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446462016264 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 446462016265 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 446462016266 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 446462016267 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 446462016268 F0F1 ATP synthase subunit C; Validated; Region: PRK07874 446462016269 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 446462016270 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 446462016271 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 446462016272 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 446462016273 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 446462016274 Mg++ binding site [ion binding]; other site 446462016275 putative catalytic motif [active] 446462016276 substrate binding site [chemical binding]; other site 446462016277 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 446462016278 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446462016279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462016280 S-adenosylmethionine binding site [chemical binding]; other site 446462016281 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 446462016282 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 446462016283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462016284 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446462016285 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 446462016286 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 446462016287 peptide chain release factor 1; Validated; Region: prfA; PRK00591 446462016288 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446462016289 RF-1 domain; Region: RF-1; pfam00472 446462016290 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 446462016291 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 446462016292 transcription termination factor Rho; Provisional; Region: PRK12608 446462016293 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446462016294 RNA binding site [nucleotide binding]; other site 446462016295 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446462016296 Walker A motif; other site 446462016297 ATP binding site [chemical binding]; other site 446462016298 Walker B motif; other site 446462016299 homoserine kinase; Provisional; Region: PRK01212 446462016300 threonine synthase; Reviewed; Region: PRK06721 446462016301 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446462016302 homodimer interface [polypeptide binding]; other site 446462016303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462016304 catalytic residue [active] 446462016305 homoserine dehydrogenase; Provisional; Region: PRK06349 446462016306 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 446462016307 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 446462016308 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 446462016309 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446462016310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446462016311 active site 446462016312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462016313 substrate binding site [chemical binding]; other site 446462016314 catalytic residues [active] 446462016315 dimer interface [polypeptide binding]; other site 446462016316 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 446462016317 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 446462016318 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446462016319 active site 446462016320 HIGH motif; other site 446462016321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462016322 KMSK motif region; other site 446462016323 tRNA binding surface [nucleotide binding]; other site 446462016324 DALR anticodon binding domain; Region: DALR_1; smart00836 446462016325 anticodon binding site; other site 446462016326 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 446462016327 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446462016328 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446462016329 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446462016330 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446462016331 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 446462016332 Uncharacterized conserved protein [Function unknown]; Region: COG1479 446462016333 Protein of unknown function DUF262; Region: DUF262; pfam03235 446462016334 Uncharacterized conserved protein [Function unknown]; Region: COG3472 446462016335 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446462016336 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462016337 AAA ATPase domain; Region: AAA_16; pfam13191 446462016338 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446462016339 Walker A motif; other site 446462016340 ATP binding site [chemical binding]; other site 446462016341 Walker B motif; other site 446462016342 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462016343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462016344 sequence-specific DNA binding site [nucleotide binding]; other site 446462016345 salt bridge; other site 446462016346 Fic family protein [Function unknown]; Region: COG3177 446462016347 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446462016348 hydrophobic ligand binding site; other site 446462016349 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 446462016350 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446462016351 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462016352 GTPase RsgA; Reviewed; Region: PRK01889 446462016353 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446462016354 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446462016355 GTP/Mg2+ binding site [chemical binding]; other site 446462016356 G4 box; other site 446462016357 G5 box; other site 446462016358 G1 box; other site 446462016359 Switch I region; other site 446462016360 G2 box; other site 446462016361 G3 box; other site 446462016362 Switch II region; other site 446462016363 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 446462016364 NADPH bind site [chemical binding]; other site 446462016365 putative FMN binding site [chemical binding]; other site 446462016366 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462016367 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462016368 active site 446462016369 catalytic tetrad [active] 446462016370 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 446462016371 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462016372 ligand binding site [chemical binding]; other site 446462016373 dimerization interface [polypeptide binding]; other site 446462016374 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 446462016375 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446462016376 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 446462016377 Melibiase; Region: Melibiase; pfam02065 446462016378 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446462016379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462016380 Walker A/P-loop; other site 446462016381 ATP binding site [chemical binding]; other site 446462016382 Q-loop/lid; other site 446462016383 ABC transporter signature motif; other site 446462016384 Walker B; other site 446462016385 D-loop; other site 446462016386 H-loop/switch region; other site 446462016387 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462016388 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446462016389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462016390 dimer interface [polypeptide binding]; other site 446462016391 conserved gate region; other site 446462016392 putative PBP binding loops; other site 446462016393 ABC-ATPase subunit interface; other site 446462016394 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446462016395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446462016396 Walker A/P-loop; other site 446462016397 ATP binding site [chemical binding]; other site 446462016398 Q-loop/lid; other site 446462016399 ABC transporter signature motif; other site 446462016400 Walker B; other site 446462016401 D-loop; other site 446462016402 H-loop/switch region; other site 446462016403 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446462016404 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446462016405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462016406 dimer interface [polypeptide binding]; other site 446462016407 conserved gate region; other site 446462016408 putative PBP binding loops; other site 446462016409 ABC-ATPase subunit interface; other site 446462016410 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446462016411 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446462016412 substrate binding site [chemical binding]; other site 446462016413 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446462016414 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462016415 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462016416 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446462016417 active site 446462016418 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446462016419 non-prolyl cis peptide bond; other site 446462016420 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462016421 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 446462016422 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446462016423 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 446462016424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462016425 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446462016426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462016427 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446462016428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 446462016429 Helix-turn-helix domain; Region: HTH_18; pfam12833 446462016430 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446462016431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462016432 NAD(P) binding site [chemical binding]; other site 446462016433 active site 446462016434 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446462016435 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446462016436 tetramer interface [polypeptide binding]; other site 446462016437 active site 446462016438 Mg2+/Mn2+ binding site [ion binding]; other site 446462016439 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462016440 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 446462016441 putative NAD(P) binding site [chemical binding]; other site 446462016442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462016443 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462016444 putative DNA binding site [nucleotide binding]; other site 446462016445 putative Zn2+ binding site [ion binding]; other site 446462016446 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446462016447 active site 446462016448 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 446462016449 non-specific DNA interactions [nucleotide binding]; other site 446462016450 DNA binding site [nucleotide binding] 446462016451 sequence specific DNA binding site [nucleotide binding]; other site 446462016452 putative cAMP binding site [chemical binding]; other site 446462016453 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462016454 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446462016455 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446462016456 Beta-lactamase; Region: Beta-lactamase; pfam00144 446462016457 Cellulose binding domain; Region: CBM_2; pfam00553 446462016458 Glyco_18 domain; Region: Glyco_18; smart00636 446462016459 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446462016460 active site 446462016461 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 446462016462 AAA domain; Region: AAA_30; pfam13604 446462016463 Family description; Region: UvrD_C_2; pfam13538 446462016464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462016465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462016466 active site 446462016467 phosphorylation site [posttranslational modification] 446462016468 intermolecular recognition site; other site 446462016469 dimerization interface [polypeptide binding]; other site 446462016470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462016471 DNA binding site [nucleotide binding] 446462016472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462016473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462016474 dimerization interface [polypeptide binding]; other site 446462016475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462016476 dimer interface [polypeptide binding]; other site 446462016477 phosphorylation site [posttranslational modification] 446462016478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462016479 ATP binding site [chemical binding]; other site 446462016480 Mg2+ binding site [ion binding]; other site 446462016481 G-X-G motif; other site 446462016482 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 446462016483 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 446462016484 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446462016485 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462016486 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 446462016487 active site 446462016488 catalytic residues [active] 446462016489 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 446462016490 FAD binding domain; Region: FAD_binding_2; pfam00890 446462016491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462016492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446462016493 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446462016494 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446462016495 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446462016496 EspG family; Region: ESX-1_EspG; pfam14011 446462016497 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446462016498 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446462016499 NB-ARC domain; Region: NB-ARC; pfam00931 446462016500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462016501 TPR motif; other site 446462016502 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462016503 binding surface 446462016504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462016505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462016506 binding surface 446462016507 TPR motif; other site 446462016508 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462016509 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 446462016510 PAS domain S-box; Region: sensory_box; TIGR00229 446462016511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462016512 putative active site [active] 446462016513 heme pocket [chemical binding]; other site 446462016514 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462016515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462016516 metal binding site [ion binding]; metal-binding site 446462016517 active site 446462016518 I-site; other site 446462016519 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462016520 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446462016521 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 446462016522 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462016523 active site 446462016524 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462016525 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446462016526 substrate binding site [chemical binding]; other site 446462016527 oxyanion hole (OAH) forming residues; other site 446462016528 trimer interface [polypeptide binding]; other site 446462016529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462016530 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462016531 active site 446462016532 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446462016533 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462016534 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462016535 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 446462016536 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446462016537 carboxyltransferase (CT) interaction site; other site 446462016538 biotinylation site [posttranslational modification]; other site 446462016539 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 446462016540 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446462016541 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446462016542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462016543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462016544 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 446462016545 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446462016546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462016547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462016548 active site 446462016549 phosphorylation site [posttranslational modification] 446462016550 intermolecular recognition site; other site 446462016551 dimerization interface [polypeptide binding]; other site 446462016552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462016553 DNA binding residues [nucleotide binding] 446462016554 dimerization interface [polypeptide binding]; other site 446462016555 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462016556 Histidine kinase; Region: HisKA_3; pfam07730 446462016557 Cellulose binding domain; Region: CBM_2; pfam00553 446462016558 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446462016559 Interdomain contacts; other site 446462016560 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 446462016561 active site 446462016562 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 446462016563 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 446462016564 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 446462016565 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446462016566 homodimer interface [polypeptide binding]; other site 446462016567 substrate-cofactor binding pocket; other site 446462016568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462016569 catalytic residue [active] 446462016570 putative oxidoreductase; Provisional; Region: PRK11579 446462016571 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462016572 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462016573 Helix-turn-helix domain; Region: HTH_17; pfam12728 446462016574 Subtilisin inhibitor-like; Region: SSI; cl11594 446462016575 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 446462016576 catalytic residues [active] 446462016577 dimer interface [polypeptide binding]; other site 446462016578 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 446462016579 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 446462016580 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 446462016581 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446462016582 lipoyl attachment site [posttranslational modification]; other site 446462016583 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446462016584 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 446462016585 hexamer interface [polypeptide binding]; other site 446462016586 ligand binding site [chemical binding]; other site 446462016587 putative active site [active] 446462016588 NAD(P) binding site [chemical binding]; other site 446462016589 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462016590 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446462016591 Walker A/P-loop; other site 446462016592 ATP binding site [chemical binding]; other site 446462016593 Q-loop/lid; other site 446462016594 ABC transporter signature motif; other site 446462016595 Walker B; other site 446462016596 D-loop; other site 446462016597 H-loop/switch region; other site 446462016598 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 446462016599 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446462016600 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446462016601 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462016602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462016603 Walker A/P-loop; other site 446462016604 ATP binding site [chemical binding]; other site 446462016605 Q-loop/lid; other site 446462016606 ABC transporter signature motif; other site 446462016607 Walker B; other site 446462016608 D-loop; other site 446462016609 H-loop/switch region; other site 446462016610 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 446462016611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446462016612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462016613 Walker A/P-loop; other site 446462016614 ATP binding site [chemical binding]; other site 446462016615 Q-loop/lid; other site 446462016616 ABC transporter signature motif; other site 446462016617 Walker B; other site 446462016618 D-loop; other site 446462016619 H-loop/switch region; other site 446462016620 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446462016621 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446462016622 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 446462016623 TPP-binding site [chemical binding]; other site 446462016624 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 446462016625 dimer interface [polypeptide binding]; other site 446462016626 PYR/PP interface [polypeptide binding]; other site 446462016627 TPP binding site [chemical binding]; other site 446462016628 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446462016629 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462016630 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462016631 active site 446462016632 catalytic tetrad [active] 446462016633 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462016634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462016635 non-specific DNA binding site [nucleotide binding]; other site 446462016636 salt bridge; other site 446462016637 sequence-specific DNA binding site [nucleotide binding]; other site 446462016638 Domain of unknown function (DUF955); Region: DUF955; cl01076 446462016639 AAA ATPase domain; Region: AAA_16; pfam13191 446462016640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462016641 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462016642 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462016643 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 446462016644 imidazolonepropionase; Provisional; Region: PRK14085 446462016645 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462016646 active site 446462016647 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462016648 active site 446462016649 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 446462016650 allantoate amidohydrolase; Reviewed; Region: PRK09290 446462016651 active site 446462016652 metal binding site [ion binding]; metal-binding site 446462016653 dimer interface [polypeptide binding]; other site 446462016654 urocanate hydratase; Provisional; Region: PRK05414 446462016655 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446462016656 active sites [active] 446462016657 tetramer interface [polypeptide binding]; other site 446462016658 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446462016659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462016660 putative DNA binding site [nucleotide binding]; other site 446462016661 putative Zn2+ binding site [ion binding]; other site 446462016662 Bacterial transcriptional regulator; Region: IclR; pfam01614 446462016663 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 446462016664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462016665 ABC-ATPase subunit interface; other site 446462016666 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 446462016667 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446462016668 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 446462016669 Walker A/P-loop; other site 446462016670 ATP binding site [chemical binding]; other site 446462016671 Q-loop/lid; other site 446462016672 ABC transporter signature motif; other site 446462016673 Walker B; other site 446462016674 D-loop; other site 446462016675 H-loop/switch region; other site 446462016676 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446462016677 Protein of unknown function DUF43; Region: DUF43; pfam01861 446462016678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462016679 PAS fold; Region: PAS_3; pfam08447 446462016680 putative active site [active] 446462016681 heme pocket [chemical binding]; other site 446462016682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462016683 PAS domain; Region: PAS_9; pfam13426 446462016684 putative active site [active] 446462016685 heme pocket [chemical binding]; other site 446462016686 PAS domain S-box; Region: sensory_box; TIGR00229 446462016687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462016688 putative active site [active] 446462016689 heme pocket [chemical binding]; other site 446462016690 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462016691 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462016692 metal binding site [ion binding]; metal-binding site 446462016693 active site 446462016694 I-site; other site 446462016695 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462016696 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446462016697 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446462016698 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 446462016699 NAD(P) binding pocket [chemical binding]; other site 446462016700 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 446462016701 Predicted transcriptional regulator [Transcription]; Region: COG2932 446462016702 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446462016703 Catalytic site [active] 446462016704 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 446462016705 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 446462016706 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 446462016707 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462016708 catalytic core [active] 446462016709 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446462016710 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446462016711 active site 446462016712 substrate binding sites [chemical binding]; other site 446462016713 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446462016714 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446462016715 Transcription factor WhiB; Region: Whib; pfam02467 446462016716 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 446462016717 PAS fold; Region: PAS_4; pfam08448 446462016718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 446462016719 Histidine kinase; Region: HisKA_2; pfam07568 446462016720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462016721 ATP binding site [chemical binding]; other site 446462016722 Mg2+ binding site [ion binding]; other site 446462016723 G-X-G motif; other site 446462016724 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 446462016725 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446462016726 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462016727 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462016728 DNA binding residues [nucleotide binding] 446462016729 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 446462016730 putative deacylase active site [active] 446462016731 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 446462016732 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 446462016733 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 446462016734 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 446462016735 hinge; other site 446462016736 active site 446462016737 Predicted GTPases [General function prediction only]; Region: COG1162 446462016738 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446462016739 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446462016740 GTP/Mg2+ binding site [chemical binding]; other site 446462016741 G4 box; other site 446462016742 G1 box; other site 446462016743 Switch I region; other site 446462016744 G2 box; other site 446462016745 G3 box; other site 446462016746 Switch II region; other site 446462016747 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446462016748 active site 446462016749 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 446462016750 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 446462016751 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 446462016752 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446462016753 active site 446462016754 ATP binding site [chemical binding]; other site 446462016755 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446462016756 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446462016757 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446462016758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462016759 active site 446462016760 motif I; other site 446462016761 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446462016762 motif II; other site 446462016763 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 446462016764 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 446462016765 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 446462016766 30S subunit binding site; other site 446462016767 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 446462016768 lipoprotein LpqB; Provisional; Region: PRK13616 446462016769 Sporulation and spore germination; Region: Germane; pfam10646 446462016770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462016771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446462016772 dimerization interface [polypeptide binding]; other site 446462016773 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462016774 dimer interface [polypeptide binding]; other site 446462016775 phosphorylation site [posttranslational modification] 446462016776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462016777 ATP binding site [chemical binding]; other site 446462016778 Mg2+ binding site [ion binding]; other site 446462016779 G-X-G motif; other site 446462016780 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462016781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462016782 active site 446462016783 phosphorylation site [posttranslational modification] 446462016784 intermolecular recognition site; other site 446462016785 dimerization interface [polypeptide binding]; other site 446462016786 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462016787 DNA binding site [nucleotide binding] 446462016788 thymidylate kinase; Validated; Region: PRK07933 446462016789 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 446462016790 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462016791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462016792 non-specific DNA binding site [nucleotide binding]; other site 446462016793 salt bridge; other site 446462016794 sequence-specific DNA binding site [nucleotide binding]; other site 446462016795 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446462016796 Ligand Binding Site [chemical binding]; other site 446462016797 Molecular Tunnel; other site 446462016798 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446462016799 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 446462016800 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446462016801 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462016802 Adenosylhomocysteinase; Provisional; Region: PTZ00075 446462016803 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 446462016804 homotetramer interface [polypeptide binding]; other site 446462016805 ligand binding site [chemical binding]; other site 446462016806 catalytic site [active] 446462016807 NAD binding site [chemical binding]; other site 446462016808 amino acid transporter; Region: 2A0306; TIGR00909 446462016809 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 446462016810 Cation efflux family; Region: Cation_efflux; pfam01545 446462016811 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 446462016812 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446462016813 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446462016814 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 446462016815 Trm112p-like protein; Region: Trm112p; cl01066 446462016816 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 446462016817 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 446462016818 active site 446462016819 substrate binding site [chemical binding]; other site 446462016820 metal binding site [ion binding]; metal-binding site 446462016821 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 446462016822 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 446462016823 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446462016824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462016825 Transcription factor WhiB; Region: Whib; pfam02467 446462016826 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 446462016827 active site 446462016828 putative substrate binding region [chemical binding]; other site 446462016829 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 446462016830 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 446462016831 dimer interface [polypeptide binding]; other site 446462016832 substrate binding site [chemical binding]; other site 446462016833 phosphate binding site [ion binding]; other site 446462016834 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 446462016835 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 446462016836 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 446462016837 putative FMN binding site [chemical binding]; other site 446462016838 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 446462016839 nudix motif; other site 446462016840 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 446462016841 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446462016842 minor groove reading motif; other site 446462016843 helix-hairpin-helix signature motif; other site 446462016844 substrate binding pocket [chemical binding]; other site 446462016845 active site 446462016846 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 446462016847 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 446462016848 active site 446462016849 Substrate binding site; other site 446462016850 Mg++ binding site; other site 446462016851 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 446462016852 N-terminal domain interface [polypeptide binding]; other site 446462016853 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462016854 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462016855 active site 446462016856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446462016857 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462016858 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 446462016859 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 446462016860 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462016861 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462016862 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 446462016863 Probable Catalytic site; other site 446462016864 metal-binding site 446462016865 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446462016866 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 446462016867 Probable Catalytic site; other site 446462016868 metal-binding site 446462016869 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446462016870 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462016871 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 446462016872 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446462016873 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 446462016874 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 446462016875 NADP binding site [chemical binding]; other site 446462016876 active site 446462016877 putative substrate binding site [chemical binding]; other site 446462016878 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 446462016879 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 446462016880 NAD binding site [chemical binding]; other site 446462016881 substrate binding site [chemical binding]; other site 446462016882 homodimer interface [polypeptide binding]; other site 446462016883 active site 446462016884 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446462016885 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446462016886 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446462016887 TIGR03089 family protein; Region: TIGR03089 446462016888 DoxX; Region: DoxX; pfam07681 446462016889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462016890 dimerization interface [polypeptide binding]; other site 446462016891 putative DNA binding site [nucleotide binding]; other site 446462016892 putative Zn2+ binding site [ion binding]; other site 446462016893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462016894 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 446462016895 non-specific DNA binding site [nucleotide binding]; other site 446462016896 salt bridge; other site 446462016897 sequence-specific DNA binding site [nucleotide binding]; other site 446462016898 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462016899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462016900 DNA-binding site [nucleotide binding]; DNA binding site 446462016901 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446462016902 Helix-turn-helix domain; Region: HTH_17; pfam12728 446462016903 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 446462016904 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462016905 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446462016906 active site 446462016907 DNA binding site [nucleotide binding] 446462016908 Int/Topo IB signature motif; other site 446462016909 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462016910 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 446462016911 FAD binding site [chemical binding]; other site 446462016912 homotetramer interface [polypeptide binding]; other site 446462016913 substrate binding pocket [chemical binding]; other site 446462016914 catalytic base [active] 446462016915 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 446462016916 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 446462016917 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462016918 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446462016919 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446462016920 Walker A/P-loop; other site 446462016921 ATP binding site [chemical binding]; other site 446462016922 Q-loop/lid; other site 446462016923 ABC transporter signature motif; other site 446462016924 Walker B; other site 446462016925 D-loop; other site 446462016926 H-loop/switch region; other site 446462016927 Predicted transcriptional regulators [Transcription]; Region: COG1725 446462016928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462016929 DNA-binding site [nucleotide binding]; DNA binding site 446462016930 Helix-turn-helix domain; Region: HTH_31; pfam13560 446462016931 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462016932 Immunity protein Imm1; Region: Imm1; pfam14430 446462016933 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462016934 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462016935 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462016936 DNA binding residues [nucleotide binding] 446462016937 Putative zinc-finger; Region: zf-HC2; pfam13490 446462016938 Predicted membrane protein [Function unknown]; Region: COG2246 446462016939 GtrA-like protein; Region: GtrA; pfam04138 446462016940 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446462016941 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 446462016942 active site 446462016943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462016944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462016945 active site 446462016946 phosphorylation site [posttranslational modification] 446462016947 intermolecular recognition site; other site 446462016948 dimerization interface [polypeptide binding]; other site 446462016949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462016950 DNA binding site [nucleotide binding] 446462016951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446462016952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462016953 ATP binding site [chemical binding]; other site 446462016954 Mg2+ binding site [ion binding]; other site 446462016955 G-X-G motif; other site 446462016956 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 446462016957 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 446462016958 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 446462016959 active site 446462016960 catalytic residues [active] 446462016961 metal binding site [ion binding]; metal-binding site 446462016962 Bacterial PH domain; Region: DUF304; pfam03703 446462016963 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446462016964 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 446462016965 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 446462016966 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446462016967 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446462016968 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446462016969 Maf-like protein; Reviewed; Region: PRK00148 446462016970 Maf-like protein; Region: Maf; pfam02545 446462016971 putative active site [active] 446462016972 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 446462016973 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446462016974 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 446462016975 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446462016976 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 446462016977 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446462016978 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446462016979 carboxyltransferase (CT) interaction site; other site 446462016980 biotinylation site [posttranslational modification]; other site 446462016981 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446462016982 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446462016983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462016984 motif II; other site 446462016985 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 446462016986 EspG family; Region: ESX-1_EspG; pfam14011 446462016987 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 446462016988 putative active site pocket [active] 446462016989 dimerization interface [polypeptide binding]; other site 446462016990 putative catalytic residue [active] 446462016991 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 446462016992 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446462016993 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462016994 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446462016995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462016996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462016997 active site 446462016998 phosphorylation site [posttranslational modification] 446462016999 intermolecular recognition site; other site 446462017000 dimerization interface [polypeptide binding]; other site 446462017001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462017002 DNA binding residues [nucleotide binding] 446462017003 dimerization interface [polypeptide binding]; other site 446462017004 Histidine kinase; Region: HisKA_3; pfam07730 446462017005 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446462017006 ATP binding site [chemical binding]; other site 446462017007 Mg2+ binding site [ion binding]; other site 446462017008 G-X-G motif; other site 446462017009 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462017010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462017011 Walker A/P-loop; other site 446462017012 ATP binding site [chemical binding]; other site 446462017013 Q-loop/lid; other site 446462017014 ABC transporter signature motif; other site 446462017015 Walker B; other site 446462017016 D-loop; other site 446462017017 H-loop/switch region; other site 446462017018 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446462017019 glycerol kinase; Provisional; Region: glpK; PRK00047 446462017020 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 446462017021 N- and C-terminal domain interface [polypeptide binding]; other site 446462017022 active site 446462017023 MgATP binding site [chemical binding]; other site 446462017024 catalytic site [active] 446462017025 metal binding site [ion binding]; metal-binding site 446462017026 putative homotetramer interface [polypeptide binding]; other site 446462017027 glycerol binding site [chemical binding]; other site 446462017028 homodimer interface [polypeptide binding]; other site 446462017029 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 446462017030 amphipathic channel; other site 446462017031 Asn-Pro-Ala signature motifs; other site 446462017032 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446462017033 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446462017034 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 446462017035 metal binding site [ion binding]; metal-binding site 446462017036 putative dimer interface [polypeptide binding]; other site 446462017037 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446462017038 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446462017039 metal binding site [ion binding]; metal-binding site 446462017040 membrane ATPase/protein kinase; Provisional; Region: PRK09435 446462017041 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 446462017042 Walker A; other site 446462017043 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 446462017044 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 446462017045 active site 446462017046 substrate binding site [chemical binding]; other site 446462017047 coenzyme B12 binding site [chemical binding]; other site 446462017048 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 446462017049 B12 binding site [chemical binding]; other site 446462017050 cobalt ligand [ion binding]; other site 446462017051 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 446462017052 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 446462017053 heterodimer interface [polypeptide binding]; other site 446462017054 substrate interaction site [chemical binding]; other site 446462017055 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462017056 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462017057 active site 446462017058 ATP binding site [chemical binding]; other site 446462017059 substrate binding site [chemical binding]; other site 446462017060 activation loop (A-loop); other site 446462017061 purine nucleoside phosphorylase; Provisional; Region: PRK08202 446462017062 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 446462017063 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 446462017064 active site 446462017065 substrate binding site [chemical binding]; other site 446462017066 metal binding site [ion binding]; metal-binding site 446462017067 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 446462017068 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462017069 DNA binding residues [nucleotide binding] 446462017070 putative dimer interface [polypeptide binding]; other site 446462017071 Fic/DOC family; Region: Fic; cl00960 446462017072 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 446462017073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462017074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462017075 WHG domain; Region: WHG; pfam13305 446462017076 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462017077 active site 446462017078 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446462017079 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462017080 active site 446462017081 metal binding site [ion binding]; metal-binding site 446462017082 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446462017083 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446462017084 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446462017085 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446462017086 active site 446462017087 metal binding site [ion binding]; metal-binding site 446462017088 NACHT domain; Region: NACHT; pfam05729 446462017089 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 446462017090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446462017091 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446462017092 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446462017093 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 446462017094 structural tetrad; other site 446462017095 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446462017096 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 446462017097 structural tetrad; other site 446462017098 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462017099 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462017100 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462017101 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462017102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462017103 non-specific DNA binding site [nucleotide binding]; other site 446462017104 salt bridge; other site 446462017105 sequence-specific DNA binding site [nucleotide binding]; other site 446462017106 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462017107 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446462017108 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446462017109 AAA ATPase domain; Region: AAA_16; pfam13191 446462017110 NB-ARC domain; Region: NB-ARC; pfam00931 446462017111 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446462017112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446462017113 binding surface 446462017114 TPR motif; other site 446462017115 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446462017116 NlpC/P60 family; Region: NLPC_P60; pfam00877 446462017117 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446462017118 adenosine deaminase; Provisional; Region: PRK09358 446462017119 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446462017120 active site 446462017121 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 446462017122 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446462017123 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446462017124 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446462017125 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 446462017126 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 446462017127 active site 446462017128 catalytic motif [active] 446462017129 Zn binding site [ion binding]; other site 446462017130 Uncharacterized ABC-type transport system, permease component [General function prediction only]; Region: COG1079 446462017131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462017132 TM-ABC transporter signature motif; other site 446462017133 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462017134 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446462017135 TM-ABC transporter signature motif; other site 446462017136 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 446462017137 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446462017138 Walker A/P-loop; other site 446462017139 ATP binding site [chemical binding]; other site 446462017140 Q-loop/lid; other site 446462017141 ABC transporter signature motif; other site 446462017142 Walker B; other site 446462017143 D-loop; other site 446462017144 H-loop/switch region; other site 446462017145 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446462017146 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 446462017147 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 446462017148 ligand binding site [chemical binding]; other site 446462017149 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 446462017150 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 446462017151 putative Iron-sulfur protein interface [polypeptide binding]; other site 446462017152 putative proximal heme binding site [chemical binding]; other site 446462017153 putative SdhD-like interface [polypeptide binding]; other site 446462017154 putative distal heme binding site [chemical binding]; other site 446462017155 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 446462017156 putative Iron-sulfur protein interface [polypeptide binding]; other site 446462017157 putative proximal heme binding site [chemical binding]; other site 446462017158 putative SdhC-like subunit interface [polypeptide binding]; other site 446462017159 putative distal heme binding site [chemical binding]; other site 446462017160 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 446462017161 L-aspartate oxidase; Provisional; Region: PRK06175 446462017162 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446462017163 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 446462017164 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 446462017165 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 446462017166 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 446462017167 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 446462017168 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446462017169 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446462017170 active site 446462017171 HIGH motif; other site 446462017172 dimer interface [polypeptide binding]; other site 446462017173 KMSKS motif; other site 446462017174 FO synthase; Reviewed; Region: fbiC; PRK09234 446462017175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446462017176 FeS/SAM binding site; other site 446462017177 Protein of unknown function DUF86; Region: DUF86; pfam01934 446462017178 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446462017179 active site 446462017180 NTP binding site [chemical binding]; other site 446462017181 metal binding triad [ion binding]; metal-binding site 446462017182 antibiotic binding site [chemical binding]; other site 446462017183 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 446462017184 putative active site [active] 446462017185 putative catalytic site [active] 446462017186 putative DNA binding site [nucleotide binding]; other site 446462017187 putative phosphate binding site [ion binding]; other site 446462017188 metal binding site A [ion binding]; metal-binding site 446462017189 putative AP binding site [nucleotide binding]; other site 446462017190 putative metal binding site B [ion binding]; other site 446462017191 isocitrate dehydrogenase; Validated; Region: PRK08299 446462017192 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 446462017193 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446462017194 HSP70 interaction site [polypeptide binding]; other site 446462017195 Nuclease-related domain; Region: NERD; pfam08378 446462017196 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462017197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462017198 active site 446462017199 ATP binding site [chemical binding]; other site 446462017200 substrate binding site [chemical binding]; other site 446462017201 activation loop (A-loop); other site 446462017202 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 446462017203 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446462017204 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 446462017205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462017206 Walker A/P-loop; other site 446462017207 ATP binding site [chemical binding]; other site 446462017208 Q-loop/lid; other site 446462017209 ABC transporter signature motif; other site 446462017210 Walker B; other site 446462017211 D-loop; other site 446462017212 H-loop/switch region; other site 446462017213 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 446462017214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462017215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462017216 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 446462017217 active site 446462017218 malate dehydrogenase; Provisional; Region: PRK05442 446462017219 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 446462017220 NAD(P) binding site [chemical binding]; other site 446462017221 dimer interface [polypeptide binding]; other site 446462017222 malate binding site [chemical binding]; other site 446462017223 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446462017224 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446462017225 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446462017226 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446462017227 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446462017228 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 446462017229 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 446462017230 Protein of unknown function, DUF606; Region: DUF606; pfam04657 446462017231 Protein of unknown function, DUF606; Region: DUF606; pfam04657 446462017232 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 446462017233 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446462017234 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 446462017235 homodimer interface [polypeptide binding]; other site 446462017236 NADP binding site [chemical binding]; other site 446462017237 substrate binding site [chemical binding]; other site 446462017238 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 446462017239 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 446462017240 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 446462017241 purine monophosphate binding site [chemical binding]; other site 446462017242 dimer interface [polypeptide binding]; other site 446462017243 putative catalytic residues [active] 446462017244 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 446462017245 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 446462017246 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 446462017247 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 446462017248 active site 446462017249 cosubstrate binding site; other site 446462017250 substrate binding site [chemical binding]; other site 446462017251 catalytic site [active] 446462017252 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446462017253 CoA binding domain; Region: CoA_binding; smart00881 446462017254 CoA-ligase; Region: Ligase_CoA; pfam00549 446462017255 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446462017256 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 446462017257 CoA-ligase; Region: Ligase_CoA; pfam00549 446462017258 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 446462017259 Peptidase family M23; Region: Peptidase_M23; pfam01551 446462017260 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 446462017261 Part of AAA domain; Region: AAA_19; pfam13245 446462017262 Family description; Region: UvrD_C_2; pfam13538 446462017263 Chorismate mutase type II; Region: CM_2; cl00693 446462017264 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 446462017265 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 446462017266 active site 446462017267 metal binding site [ion binding]; metal-binding site 446462017268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462017269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462017270 active site 446462017271 ATP binding site [chemical binding]; other site 446462017272 substrate binding site [chemical binding]; other site 446462017273 activation loop (A-loop); other site 446462017274 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446462017275 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446462017276 active site 446462017277 ATP binding site [chemical binding]; other site 446462017278 substrate binding site [chemical binding]; other site 446462017279 activation loop (A-loop); other site 446462017280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462017281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462017282 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446462017283 putative dimerization interface [polypeptide binding]; other site 446462017284 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 446462017285 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462017286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462017287 active site 446462017288 phosphorylation site [posttranslational modification] 446462017289 intermolecular recognition site; other site 446462017290 dimerization interface [polypeptide binding]; other site 446462017291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462017292 DNA binding residues [nucleotide binding] 446462017293 dimerization interface [polypeptide binding]; other site 446462017294 PspC domain; Region: PspC; pfam04024 446462017295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446462017296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462017297 ATP binding site [chemical binding]; other site 446462017298 G-X-G motif; other site 446462017299 PspC domain; Region: PspC; pfam04024 446462017300 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446462017301 GMP synthase; Reviewed; Region: guaA; PRK00074 446462017302 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 446462017303 AMP/PPi binding site [chemical binding]; other site 446462017304 candidate oxyanion hole; other site 446462017305 catalytic triad [active] 446462017306 potential glutamine specificity residues [chemical binding]; other site 446462017307 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 446462017308 ATP Binding subdomain [chemical binding]; other site 446462017309 Ligand Binding sites [chemical binding]; other site 446462017310 Dimerization subdomain; other site 446462017311 Phosphotransferase enzyme family; Region: APH; pfam01636 446462017312 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 446462017313 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446462017314 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446462017315 NAD(P) binding site [chemical binding]; other site 446462017316 catalytic residues [active] 446462017317 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446462017318 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446462017319 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 446462017320 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446462017321 phosphate binding site [ion binding]; other site 446462017322 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 446462017323 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446462017324 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 446462017325 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446462017326 active site 446462017327 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 446462017328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462017329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462017330 DNA binding residues [nucleotide binding] 446462017331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462017332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462017333 active site 446462017334 phosphorylation site [posttranslational modification] 446462017335 intermolecular recognition site; other site 446462017336 dimerization interface [polypeptide binding]; other site 446462017337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462017338 DNA binding residues [nucleotide binding] 446462017339 dimerization interface [polypeptide binding]; other site 446462017340 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462017341 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462017342 DNA binding residues [nucleotide binding] 446462017343 Transcription factor WhiB; Region: Whib; pfam02467 446462017344 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446462017345 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446462017346 ring oligomerisation interface [polypeptide binding]; other site 446462017347 ATP/Mg binding site [chemical binding]; other site 446462017348 stacking interactions; other site 446462017349 hinge regions; other site 446462017350 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446462017351 oligomerisation interface [polypeptide binding]; other site 446462017352 mobile loop; other site 446462017353 roof hairpin; other site 446462017354 UGMP family protein; Validated; Region: PRK09604 446462017355 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 446462017356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462017357 Coenzyme A binding pocket [chemical binding]; other site 446462017358 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 446462017359 Glycoprotease family; Region: Peptidase_M22; pfam00814 446462017360 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446462017361 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446462017362 DNA binding residues [nucleotide binding] 446462017363 putative dimer interface [polypeptide binding]; other site 446462017364 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446462017365 catalytic residues [active] 446462017366 acyl-CoA synthetase; Validated; Region: PRK07787 446462017367 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462017368 acyl-activating enzyme (AAE) consensus motif; other site 446462017369 AMP binding site [chemical binding]; other site 446462017370 active site 446462017371 CoA binding site [chemical binding]; other site 446462017372 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 446462017373 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446462017374 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462017375 TAP-like protein; Region: Abhydrolase_4; pfam08386 446462017376 alanine racemase; Reviewed; Region: alr; PRK00053 446462017377 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446462017378 active site 446462017379 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446462017380 dimer interface [polypeptide binding]; other site 446462017381 substrate binding site [chemical binding]; other site 446462017382 catalytic residues [active] 446462017383 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 446462017384 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 446462017385 putative substrate binding site [chemical binding]; other site 446462017386 putative ATP binding site [chemical binding]; other site 446462017387 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 446462017388 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 446462017389 glutaminase active site [active] 446462017390 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446462017391 dimer interface [polypeptide binding]; other site 446462017392 active site 446462017393 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446462017394 dimer interface [polypeptide binding]; other site 446462017395 active site 446462017396 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446462017397 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446462017398 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 446462017399 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 446462017400 active site 446462017401 substrate binding site [chemical binding]; other site 446462017402 metal binding site [ion binding]; metal-binding site 446462017403 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 446462017404 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 446462017405 23S rRNA interface [nucleotide binding]; other site 446462017406 L3 interface [polypeptide binding]; other site 446462017407 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 446462017408 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 446462017409 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 446462017410 nucleotide binding site [chemical binding]; other site 446462017411 putative NEF/HSP70 interaction site [polypeptide binding]; other site 446462017412 SBD interface [polypeptide binding]; other site 446462017413 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 446462017414 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446462017415 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462017416 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446462017417 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462017418 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446462017419 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 446462017420 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462017421 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 446462017422 active site 446462017423 catalytic residues [active] 446462017424 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446462017425 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 446462017426 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 446462017427 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446462017428 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446462017429 calcium binding site 2 [ion binding]; other site 446462017430 active site 446462017431 catalytic triad [active] 446462017432 calcium binding site 1 [ion binding]; other site 446462017433 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 446462017434 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 446462017435 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 446462017436 active site 446462017437 dimerization interface 3.5A [polypeptide binding]; other site 446462017438 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 446462017439 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 446462017440 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 446462017441 alphaNTD homodimer interface [polypeptide binding]; other site 446462017442 alphaNTD - beta interaction site [polypeptide binding]; other site 446462017443 alphaNTD - beta' interaction site [polypeptide binding]; other site 446462017444 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 446462017445 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446462017446 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 446462017447 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446462017448 RNA binding surface [nucleotide binding]; other site 446462017449 30S ribosomal protein S11; Validated; Region: PRK05309 446462017450 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 446462017451 30S ribosomal protein S13; Region: bact_S13; TIGR03631 446462017452 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 446462017453 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 446462017454 rRNA binding site [nucleotide binding]; other site 446462017455 predicted 30S ribosome binding site; other site 446462017456 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446462017457 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446462017458 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446462017459 active site 446462017460 adenylate kinase; Reviewed; Region: adk; PRK00279 446462017461 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 446462017462 AMP-binding site [chemical binding]; other site 446462017463 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 446462017464 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 446462017465 SecY translocase; Region: SecY; pfam00344 446462017466 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 446462017467 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 446462017468 23S rRNA binding site [nucleotide binding]; other site 446462017469 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 446462017470 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 446462017471 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 446462017472 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 446462017473 5S rRNA interface [nucleotide binding]; other site 446462017474 L27 interface [polypeptide binding]; other site 446462017475 23S rRNA interface [nucleotide binding]; other site 446462017476 L5 interface [polypeptide binding]; other site 446462017477 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 446462017478 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446462017479 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446462017480 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 446462017481 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 446462017482 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 446462017483 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 446462017484 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 446462017485 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 446462017486 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 446462017487 RNA binding site [nucleotide binding]; other site 446462017488 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 446462017489 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 446462017490 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 446462017491 L23 interface [polypeptide binding]; other site 446462017492 signal recognition particle (SRP54) interaction site; other site 446462017493 trigger factor interaction site; other site 446462017494 23S rRNA interface [nucleotide binding]; other site 446462017495 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 446462017496 23S rRNA interface [nucleotide binding]; other site 446462017497 5S rRNA interface [nucleotide binding]; other site 446462017498 putative antibiotic binding site [chemical binding]; other site 446462017499 L25 interface [polypeptide binding]; other site 446462017500 L27 interface [polypeptide binding]; other site 446462017501 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 446462017502 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 446462017503 G-X-X-G motif; other site 446462017504 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 446462017505 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 446462017506 putative translocon binding site; other site 446462017507 protein-rRNA interface [nucleotide binding]; other site 446462017508 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 446462017509 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 446462017510 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 446462017511 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 446462017512 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 446462017513 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 446462017514 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 446462017515 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 446462017516 elongation factor Tu; Reviewed; Region: PRK00049 446462017517 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 446462017518 G1 box; other site 446462017519 GEF interaction site [polypeptide binding]; other site 446462017520 GTP/Mg2+ binding site [chemical binding]; other site 446462017521 Switch I region; other site 446462017522 G2 box; other site 446462017523 G3 box; other site 446462017524 Switch II region; other site 446462017525 G4 box; other site 446462017526 G5 box; other site 446462017527 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 446462017528 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 446462017529 Antibiotic Binding Site [chemical binding]; other site 446462017530 elongation factor G; Reviewed; Region: PRK00007 446462017531 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 446462017532 G1 box; other site 446462017533 putative GEF interaction site [polypeptide binding]; other site 446462017534 GTP/Mg2+ binding site [chemical binding]; other site 446462017535 Switch I region; other site 446462017536 G2 box; other site 446462017537 G3 box; other site 446462017538 Switch II region; other site 446462017539 G4 box; other site 446462017540 G5 box; other site 446462017541 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446462017542 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446462017543 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446462017544 30S ribosomal protein S7; Validated; Region: PRK05302 446462017545 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 446462017546 S17 interaction site [polypeptide binding]; other site 446462017547 S8 interaction site; other site 446462017548 16S rRNA interaction site [nucleotide binding]; other site 446462017549 streptomycin interaction site [chemical binding]; other site 446462017550 23S rRNA interaction site [nucleotide binding]; other site 446462017551 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 446462017552 Phosphotransferase enzyme family; Region: APH; pfam01636 446462017553 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446462017554 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 446462017555 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 446462017556 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 446462017557 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 446462017558 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 446462017559 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 446462017560 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 446462017561 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 446462017562 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 446462017563 DNA binding site [nucleotide binding] 446462017564 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 446462017565 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 446462017566 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446462017567 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446462017568 RPB1 interaction site [polypeptide binding]; other site 446462017569 RPB10 interaction site [polypeptide binding]; other site 446462017570 RPB11 interaction site [polypeptide binding]; other site 446462017571 RPB3 interaction site [polypeptide binding]; other site 446462017572 RPB12 interaction site [polypeptide binding]; other site 446462017573 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446462017574 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 446462017575 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 446462017576 Permease; Region: Permease; pfam02405 446462017577 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 446462017578 Permease; Region: Permease; pfam02405 446462017579 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 446462017580 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 446462017581 Walker A/P-loop; other site 446462017582 ATP binding site [chemical binding]; other site 446462017583 Q-loop/lid; other site 446462017584 ABC transporter signature motif; other site 446462017585 Walker B; other site 446462017586 D-loop; other site 446462017587 H-loop/switch region; other site 446462017588 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 446462017589 core dimer interface [polypeptide binding]; other site 446462017590 peripheral dimer interface [polypeptide binding]; other site 446462017591 L10 interface [polypeptide binding]; other site 446462017592 L11 interface [polypeptide binding]; other site 446462017593 putative EF-Tu interaction site [polypeptide binding]; other site 446462017594 putative EF-G interaction site [polypeptide binding]; other site 446462017595 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 446462017596 23S rRNA interface [nucleotide binding]; other site 446462017597 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 446462017598 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 446462017599 mRNA/rRNA interface [nucleotide binding]; other site 446462017600 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 446462017601 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446462017602 23S rRNA interface [nucleotide binding]; other site 446462017603 L7/L12 interface [polypeptide binding]; other site 446462017604 putative thiostrepton binding site; other site 446462017605 L25 interface [polypeptide binding]; other site 446462017606 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 446462017607 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 446462017608 putative homodimer interface [polypeptide binding]; other site 446462017609 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 446462017610 heterodimer interface [polypeptide binding]; other site 446462017611 homodimer interface [polypeptide binding]; other site 446462017612 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 446462017613 aspartate aminotransferase; Provisional; Region: PRK05764 446462017614 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462017615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462017616 homodimer interface [polypeptide binding]; other site 446462017617 catalytic residue [active] 446462017618 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 446462017619 active site 446462017620 catalytic site [active] 446462017621 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 446462017622 active site 446462017623 catalytic site [active] 446462017624 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 446462017625 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446462017626 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446462017627 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462017628 metal binding site [ion binding]; metal-binding site 446462017629 active site 446462017630 I-site; other site 446462017631 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462017632 HNH endonuclease; Region: HNH_2; pfam13391 446462017633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 446462017634 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 446462017635 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 446462017636 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 446462017637 substrate binding site; other site 446462017638 tetramer interface; other site 446462017639 Peptidase family M48; Region: Peptidase_M48; cl12018 446462017640 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 446462017641 4Fe-4S binding domain; Region: Fer4; pfam00037 446462017642 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 446462017643 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 446462017644 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462017645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462017646 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 446462017647 Amidinotransferase; Region: Amidinotransf; pfam02274 446462017648 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446462017649 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 446462017650 AsnC family; Region: AsnC_trans_reg; pfam01037 446462017651 enoyl-CoA hydratase; Provisional; Region: PRK05870 446462017652 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462017653 substrate binding site [chemical binding]; other site 446462017654 oxyanion hole (OAH) forming residues; other site 446462017655 trimer interface [polypeptide binding]; other site 446462017656 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 446462017657 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 446462017658 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 446462017659 dimer interface [polypeptide binding]; other site 446462017660 PYR/PP interface [polypeptide binding]; other site 446462017661 TPP binding site [chemical binding]; other site 446462017662 substrate binding site [chemical binding]; other site 446462017663 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 446462017664 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 446462017665 TPP-binding site [chemical binding]; other site 446462017666 Predicted permeases [General function prediction only]; Region: RarD; COG2962 446462017667 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446462017668 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446462017669 substrate binding pocket [chemical binding]; other site 446462017670 chain length determination region; other site 446462017671 substrate-Mg2+ binding site; other site 446462017672 catalytic residues [active] 446462017673 aspartate-rich region 1; other site 446462017674 active site lid residues [active] 446462017675 aspartate-rich region 2; other site 446462017676 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 446462017677 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446462017678 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 446462017679 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446462017680 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 446462017681 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 446462017682 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446462017683 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 446462017684 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 446462017685 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 446462017686 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 446462017687 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 446462017688 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 446462017689 4Fe-4S binding domain; Region: Fer4; pfam00037 446462017690 4Fe-4S binding domain; Region: Fer4; pfam00037 446462017691 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 446462017692 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 446462017693 NADH dehydrogenase subunit G; Validated; Region: PRK07860 446462017694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446462017695 catalytic loop [active] 446462017696 iron binding site [ion binding]; other site 446462017697 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 446462017698 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446462017699 molybdopterin cofactor binding site; other site 446462017700 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 446462017701 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 446462017702 SLBB domain; Region: SLBB; pfam10531 446462017703 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 446462017704 NADH dehydrogenase subunit E; Validated; Region: PRK07539 446462017705 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 446462017706 putative dimer interface [polypeptide binding]; other site 446462017707 [2Fe-2S] cluster binding site [ion binding]; other site 446462017708 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 446462017709 NADH dehydrogenase subunit D; Validated; Region: PRK06075 446462017710 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 446462017711 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 446462017712 NADH dehydrogenase subunit B; Validated; Region: PRK06411 446462017713 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 446462017714 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446462017715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446462017716 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446462017717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462017718 S-adenosylmethionine binding site [chemical binding]; other site 446462017719 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446462017720 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 446462017721 active site 446462017722 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 446462017723 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 446462017724 FAD binding pocket [chemical binding]; other site 446462017725 FAD binding motif [chemical binding]; other site 446462017726 phosphate binding motif [ion binding]; other site 446462017727 beta-alpha-beta structure motif; other site 446462017728 NAD(p) ribose binding residues [chemical binding]; other site 446462017729 NAD binding pocket [chemical binding]; other site 446462017730 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 446462017731 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446462017732 catalytic loop [active] 446462017733 iron binding site [ion binding]; other site 446462017734 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446462017735 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 446462017736 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 446462017737 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 446462017738 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 446462017739 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 446462017740 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 446462017741 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446462017742 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446462017743 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446462017744 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446462017745 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462017746 catalytic residue [active] 446462017747 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 446462017748 UbiA prenyltransferase family; Region: UbiA; pfam01040 446462017749 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462017750 acyl-activating enzyme (AAE) consensus motif; other site 446462017751 AMP binding site [chemical binding]; other site 446462017752 active site 446462017753 CoA binding site [chemical binding]; other site 446462017754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446462017755 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 446462017756 substrate binding site [chemical binding]; other site 446462017757 oxyanion hole (OAH) forming residues; other site 446462017758 trimer interface [polypeptide binding]; other site 446462017759 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 446462017760 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 446462017761 dimer interface [polypeptide binding]; other site 446462017762 tetramer interface [polypeptide binding]; other site 446462017763 PYR/PP interface [polypeptide binding]; other site 446462017764 TPP binding site [chemical binding]; other site 446462017765 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 446462017766 TPP-binding site; other site 446462017767 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 446462017768 Peptidase family M1; Region: Peptidase_M1; pfam01433 446462017769 Zn binding site [ion binding]; other site 446462017770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462017771 non-specific DNA binding site [nucleotide binding]; other site 446462017772 salt bridge; other site 446462017773 sequence-specific DNA binding site [nucleotide binding]; other site 446462017774 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462017775 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446462017776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446462017777 putative DNA binding site [nucleotide binding]; other site 446462017778 putative Zn2+ binding site [ion binding]; other site 446462017779 AsnC family; Region: AsnC_trans_reg; pfam01037 446462017780 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446462017781 DNA binding residues [nucleotide binding] 446462017782 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 446462017783 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 446462017784 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 446462017785 ResB-like family; Region: ResB; pfam05140 446462017786 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 446462017787 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446462017788 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 446462017789 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446462017790 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446462017791 putative NAD(P) binding site [chemical binding]; other site 446462017792 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446462017793 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446462017794 catalytic residues [active] 446462017795 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462017796 catalytic core [active] 446462017797 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 446462017798 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446462017799 inhibitor-cofactor binding pocket; inhibition site 446462017800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462017801 catalytic residue [active] 446462017802 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 446462017803 dimer interface [polypeptide binding]; other site 446462017804 active site 446462017805 Schiff base residues; other site 446462017806 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 446462017807 active site 446462017808 homodimer interface [polypeptide binding]; other site 446462017809 SAM binding site [chemical binding]; other site 446462017810 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 446462017811 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446462017812 active site 446462017813 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 446462017814 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 446462017815 domain interfaces; other site 446462017816 active site 446462017817 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 446462017818 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 446462017819 tRNA; other site 446462017820 putative tRNA binding site [nucleotide binding]; other site 446462017821 putative NADP binding site [chemical binding]; other site 446462017822 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 446462017823 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 446462017824 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 446462017825 CoA binding domain; Region: CoA_binding; smart00881 446462017826 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 446462017827 Fasciclin domain; Region: Fasciclin; pfam02469 446462017828 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 446462017829 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 446462017830 Moco binding site; other site 446462017831 metal coordination site [ion binding]; other site 446462017832 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446462017833 catalytic residues [active] 446462017834 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446462017835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446462017836 acyl-activating enzyme (AAE) consensus motif; other site 446462017837 AMP binding site [chemical binding]; other site 446462017838 active site 446462017839 CoA binding site [chemical binding]; other site 446462017840 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 446462017841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462017842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462017843 DNA binding residues [nucleotide binding] 446462017844 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446462017845 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446462017846 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446462017847 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 446462017848 putative acyl-acceptor binding pocket; other site 446462017849 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462017850 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 446462017851 putative NAD(P) binding site [chemical binding]; other site 446462017852 active site 446462017853 putative substrate binding site [chemical binding]; other site 446462017854 DNA binding domain, excisionase family; Region: excise; TIGR01764 446462017855 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 446462017856 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446462017857 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 446462017858 Proline dehydrogenase; Region: Pro_dh; cl03282 446462017859 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 446462017860 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446462017861 DNA interaction; other site 446462017862 Metal-binding active site; metal-binding site 446462017863 exopolyphosphatase; Region: exo_poly_only; TIGR03706 446462017864 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446462017865 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462017866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462017867 active site 446462017868 phosphorylation site [posttranslational modification] 446462017869 intermolecular recognition site; other site 446462017870 dimerization interface [polypeptide binding]; other site 446462017871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462017872 DNA binding site [nucleotide binding] 446462017873 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446462017874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446462017875 dimer interface [polypeptide binding]; other site 446462017876 phosphorylation site [posttranslational modification] 446462017877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462017878 ATP binding site [chemical binding]; other site 446462017879 Mg2+ binding site [ion binding]; other site 446462017880 G-X-G motif; other site 446462017881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462017882 active site 446462017883 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462017884 catalytic tetrad [active] 446462017885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462017886 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 446462017887 dimerization interface [polypeptide binding]; other site 446462017888 DNA binding residues [nucleotide binding] 446462017889 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446462017890 catalytic core [active] 446462017891 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446462017892 4-coumarate--CoA ligase; Region: PLN02246 446462017893 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 446462017894 acyl-activating enzyme (AAE) consensus motif; other site 446462017895 active site 446462017896 putative CoA binding site [chemical binding]; other site 446462017897 AMP binding site [chemical binding]; other site 446462017898 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 446462017899 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446462017900 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446462017901 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 446462017902 putative ADP-binding pocket [chemical binding]; other site 446462017903 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 446462017904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 446462017905 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 446462017906 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446462017907 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446462017908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462017909 NAD(P) binding site [chemical binding]; other site 446462017910 active site 446462017911 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 446462017912 FAD binding domain; Region: FAD_binding_4; pfam01565 446462017913 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 446462017914 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 446462017915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446462017916 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446462017917 DinB superfamily; Region: DinB_2; pfam12867 446462017918 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 446462017919 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 446462017920 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 446462017921 putative active site [active] 446462017922 putative substrate binding site [chemical binding]; other site 446462017923 putative cosubstrate binding site; other site 446462017924 catalytic site [active] 446462017925 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 446462017926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462017927 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446462017928 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 446462017929 putative deacylase active site [active] 446462017930 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462017931 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446462017932 DNA binding residues [nucleotide binding] 446462017933 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446462017934 intracellular protease, PfpI family; Region: PfpI; TIGR01382 446462017935 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 446462017936 proposed catalytic triad [active] 446462017937 conserved cys residue [active] 446462017938 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446462017939 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 446462017940 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446462017941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462017942 non-specific DNA binding site [nucleotide binding]; other site 446462017943 salt bridge; other site 446462017944 sequence-specific DNA binding site [nucleotide binding]; other site 446462017945 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446462017946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462017947 S-adenosylmethionine binding site [chemical binding]; other site 446462017948 Protein of unknown function (DUF445); Region: DUF445; pfam04286 446462017949 aminotransferase; Validated; Region: PRK07777 446462017950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462017951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462017952 homodimer interface [polypeptide binding]; other site 446462017953 catalytic residue [active] 446462017954 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 446462017955 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 446462017956 CGNR zinc finger; Region: zf-CGNR; pfam11706 446462017957 Predicted transcriptional regulators [Transcription]; Region: COG1695 446462017958 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446462017959 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446462017960 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446462017961 Walker A/P-loop; other site 446462017962 ATP binding site [chemical binding]; other site 446462017963 Q-loop/lid; other site 446462017964 ABC transporter signature motif; other site 446462017965 Walker B; other site 446462017966 D-loop; other site 446462017967 H-loop/switch region; other site 446462017968 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446462017969 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462017970 DNA-binding site [nucleotide binding]; DNA binding site 446462017971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462017972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462017973 homodimer interface [polypeptide binding]; other site 446462017974 catalytic residue [active] 446462017975 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446462017976 Predicted membrane protein [Function unknown]; Region: COG2364 446462017977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 446462017978 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446462017979 metal-binding site [ion binding] 446462017980 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446462017981 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446462017982 metal-binding site [ion binding] 446462017983 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446462017984 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446462017985 DNA-binding site [nucleotide binding]; DNA binding site 446462017986 RNA-binding motif; other site 446462017987 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462017988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462017989 substrate binding pocket [chemical binding]; other site 446462017990 membrane-bound complex binding site; other site 446462017991 hinge residues; other site 446462017992 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 446462017993 ATPase involved in DNA repair; Region: DUF3686; pfam12458 446462017994 AAA domain; Region: AAA_22; pfam13401 446462017995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462017996 Walker A motif; other site 446462017997 ATP binding site [chemical binding]; other site 446462017998 Walker B motif; other site 446462017999 arginine finger; other site 446462018000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 446462018001 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 446462018002 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 446462018003 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 446462018004 catalytic Zn binding site [ion binding]; other site 446462018005 NAD binding site [chemical binding]; other site 446462018006 structural Zn binding site [ion binding]; other site 446462018007 GXWXG protein; Region: GXWXG; pfam14231 446462018008 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 446462018009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462018010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462018011 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 446462018012 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 446462018013 FMN binding site [chemical binding]; other site 446462018014 active site 446462018015 catalytic residues [active] 446462018016 substrate binding site [chemical binding]; other site 446462018017 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462018018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462018019 metal binding site [ion binding]; metal-binding site 446462018020 active site 446462018021 I-site; other site 446462018022 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446462018023 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446462018024 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 446462018025 PhoU domain; Region: PhoU; pfam01895 446462018026 PhoU domain; Region: PhoU; pfam01895 446462018027 EspG family; Region: ESX-1_EspG; pfam14011 446462018028 PPE family; Region: PPE; pfam00823 446462018029 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 446462018030 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 446462018031 Walker A/P-loop; other site 446462018032 ATP binding site [chemical binding]; other site 446462018033 Q-loop/lid; other site 446462018034 ABC transporter signature motif; other site 446462018035 Walker B; other site 446462018036 D-loop; other site 446462018037 H-loop/switch region; other site 446462018038 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 446462018039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462018040 dimer interface [polypeptide binding]; other site 446462018041 conserved gate region; other site 446462018042 putative PBP binding loops; other site 446462018043 ABC-ATPase subunit interface; other site 446462018044 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 446462018045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462018046 dimer interface [polypeptide binding]; other site 446462018047 conserved gate region; other site 446462018048 putative PBP binding loops; other site 446462018049 ABC-ATPase subunit interface; other site 446462018050 PBP superfamily domain; Region: PBP_like_2; cl17296 446462018051 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446462018052 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446462018053 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446462018054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446462018055 DNA binding site [nucleotide binding] 446462018056 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446462018057 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446462018058 Protein of unknown function (DUF3530); Region: DUF3530; pfam12048 446462018059 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 446462018060 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446462018061 catalytic residues [active] 446462018062 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 446462018063 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446462018064 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446462018065 active site residue [active] 446462018066 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446462018067 active site residue [active] 446462018068 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 446462018069 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 446462018070 heme-binding site [chemical binding]; other site 446462018071 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 446462018072 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 446462018073 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 446462018074 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446462018075 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 446462018076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462018077 catalytic residue [active] 446462018078 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446462018079 metal binding site 2 [ion binding]; metal-binding site 446462018080 putative DNA binding helix; other site 446462018081 metal binding site 1 [ion binding]; metal-binding site 446462018082 dimer interface [polypeptide binding]; other site 446462018083 structural Zn2+ binding site [ion binding]; other site 446462018084 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 446462018085 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 446462018086 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 446462018087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462018088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462018089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446462018090 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 446462018091 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446462018092 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446462018093 ligand binding site [chemical binding]; other site 446462018094 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446462018095 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 446462018096 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446462018097 dimer interface [polypeptide binding]; other site 446462018098 PYR/PP interface [polypeptide binding]; other site 446462018099 TPP binding site [chemical binding]; other site 446462018100 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446462018101 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446462018102 TPP-binding site [chemical binding]; other site 446462018103 KduI/IolB family; Region: KduI; pfam04962 446462018104 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446462018105 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462018106 substrate binding site [chemical binding]; other site 446462018107 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446462018108 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446462018109 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446462018110 Walker A/P-loop; other site 446462018111 ATP binding site [chemical binding]; other site 446462018112 Q-loop/lid; other site 446462018113 ABC transporter signature motif; other site 446462018114 Walker B; other site 446462018115 D-loop; other site 446462018116 H-loop/switch region; other site 446462018117 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446462018118 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446462018119 TM-ABC transporter signature motif; other site 446462018120 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 446462018121 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446462018122 putative ligand binding site [chemical binding]; other site 446462018123 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446462018124 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446462018125 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446462018126 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446462018127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462018128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462018129 DNA binding site [nucleotide binding] 446462018130 domain linker motif; other site 446462018131 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462018132 dimerization interface [polypeptide binding]; other site 446462018133 ligand binding site [chemical binding]; other site 446462018134 hypothetical protein; Provisional; Region: PRK09256 446462018135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462018136 sequence-specific DNA binding site [nucleotide binding]; other site 446462018137 salt bridge; other site 446462018138 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 446462018139 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 446462018140 dimerization interface [polypeptide binding]; other site 446462018141 putative ATP binding site [chemical binding]; other site 446462018142 amidophosphoribosyltransferase; Provisional; Region: PRK07847 446462018143 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 446462018144 active site 446462018145 tetramer interface [polypeptide binding]; other site 446462018146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462018147 active site 446462018148 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446462018149 EspG family; Region: ESX-1_EspG; pfam14011 446462018150 PPE family; Region: PPE; pfam00823 446462018151 Glucose dehydrogenase; Region: glucose_DH; cd08230 446462018152 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446462018153 NADP binding site [chemical binding]; other site 446462018154 catalytic Zn binding site [ion binding]; other site 446462018155 structural Zn binding site [ion binding]; other site 446462018156 dimer interface [polypeptide binding]; other site 446462018157 PAS domain S-box; Region: sensory_box; TIGR00229 446462018158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446462018159 putative active site [active] 446462018160 heme pocket [chemical binding]; other site 446462018161 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462018162 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462018163 metal binding site [ion binding]; metal-binding site 446462018164 active site 446462018165 I-site; other site 446462018166 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446462018167 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 446462018168 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 446462018169 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446462018170 active site 446462018171 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 446462018172 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 446462018173 active site 446462018174 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 446462018175 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 446462018176 dimerization interface [polypeptide binding]; other site 446462018177 ATP binding site [chemical binding]; other site 446462018178 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 446462018179 dimerization interface [polypeptide binding]; other site 446462018180 ATP binding site [chemical binding]; other site 446462018181 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 446462018182 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 446462018183 putative active site [active] 446462018184 catalytic triad [active] 446462018185 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 446462018186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462018187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446462018188 NAD(P) binding site [chemical binding]; other site 446462018189 active site 446462018190 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 446462018191 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 446462018192 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 446462018193 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446462018194 ATP binding site [chemical binding]; other site 446462018195 active site 446462018196 substrate binding site [chemical binding]; other site 446462018197 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462018198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462018199 substrate binding pocket [chemical binding]; other site 446462018200 membrane-bound complex binding site; other site 446462018201 hinge residues; other site 446462018202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462018203 dimer interface [polypeptide binding]; other site 446462018204 conserved gate region; other site 446462018205 putative PBP binding loops; other site 446462018206 ABC-ATPase subunit interface; other site 446462018207 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446462018208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446462018209 Walker A/P-loop; other site 446462018210 ATP binding site [chemical binding]; other site 446462018211 Q-loop/lid; other site 446462018212 ABC transporter signature motif; other site 446462018213 Walker B; other site 446462018214 D-loop; other site 446462018215 H-loop/switch region; other site 446462018216 adenylosuccinate lyase; Region: purB; TIGR00928 446462018217 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446462018218 tetramer interface [polypeptide binding]; other site 446462018219 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446462018220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462018221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462018222 DNA binding residues [nucleotide binding] 446462018223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446462018224 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446462018225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462018226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462018227 DNA binding residues [nucleotide binding] 446462018228 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 446462018229 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446462018230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446462018231 catalytic residue [active] 446462018232 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 446462018233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462018234 motif II; other site 446462018235 aspartate aminotransferase; Provisional; Region: PRK05764 446462018236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462018237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462018238 homodimer interface [polypeptide binding]; other site 446462018239 catalytic residue [active] 446462018240 EspG family; Region: ESX-1_EspG; pfam14011 446462018241 EspG family; Region: ESX-1_EspG; pfam14011 446462018242 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 446462018243 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 446462018244 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 446462018245 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 446462018246 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 446462018247 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 446462018248 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 446462018249 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 446462018250 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 446462018251 putative active site [active] 446462018252 catalytic site [active] 446462018253 putative metal binding site [ion binding]; other site 446462018254 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 446462018255 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446462018256 active site 446462018257 dimer interface [polypeptide binding]; other site 446462018258 non-prolyl cis peptide bond; other site 446462018259 insertion regions; other site 446462018260 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 446462018261 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 446462018262 GDP-binding site [chemical binding]; other site 446462018263 ACT binding site; other site 446462018264 IMP binding site; other site 446462018265 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446462018266 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 446462018267 active site 446462018268 catalytic residues [active] 446462018269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446462018270 Predicted membrane protein [Function unknown]; Region: COG4129 446462018271 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 446462018272 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446462018273 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 446462018274 active site 446462018275 intersubunit interface [polypeptide binding]; other site 446462018276 zinc binding site [ion binding]; other site 446462018277 Na+ binding site [ion binding]; other site 446462018278 Domain of unknown function (DUF427); Region: DUF427; pfam04248 446462018279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446462018280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446462018281 active site 446462018282 catalytic tetrad [active] 446462018283 short chain dehydrogenase; Provisional; Region: PRK06181 446462018284 classical (c) SDRs; Region: SDR_c; cd05233 446462018285 NAD(P) binding site [chemical binding]; other site 446462018286 active site 446462018287 YCII-related domain; Region: YCII; cl00999 446462018288 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446462018289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462018290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462018291 DNA binding residues [nucleotide binding] 446462018292 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462018293 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446462018294 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 446462018295 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 446462018296 active site 446462018297 dimer interface [polypeptide binding]; other site 446462018298 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446462018299 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446462018300 FAD binding domain; Region: FAD_binding_4; pfam01565 446462018301 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 446462018302 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 446462018303 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446462018304 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 446462018305 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446462018306 active site 446462018307 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446462018308 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462018309 substrate binding site [chemical binding]; other site 446462018310 ATP binding site [chemical binding]; other site 446462018311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446462018312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446462018313 DNA binding site [nucleotide binding] 446462018314 domain linker motif; other site 446462018315 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446462018316 ligand binding site [chemical binding]; other site 446462018317 dimerization interface [polypeptide binding]; other site 446462018318 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 446462018319 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446462018320 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 446462018321 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 446462018322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446462018323 active site 446462018324 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 446462018325 classical (c) SDRs; Region: SDR_c; cd05233 446462018326 NAD(P) binding site [chemical binding]; other site 446462018327 active site 446462018328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462018329 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 446462018330 Clp amino terminal domain; Region: Clp_N; pfam02861 446462018331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462018332 Walker A motif; other site 446462018333 ATP binding site [chemical binding]; other site 446462018334 Walker B motif; other site 446462018335 arginine finger; other site 446462018336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446462018337 Walker A motif; other site 446462018338 ATP binding site [chemical binding]; other site 446462018339 Walker B motif; other site 446462018340 arginine finger; other site 446462018341 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446462018342 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446462018343 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 446462018344 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 446462018345 heme-binding site [chemical binding]; other site 446462018346 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 446462018347 FAD binding pocket [chemical binding]; other site 446462018348 FAD binding motif [chemical binding]; other site 446462018349 phosphate binding motif [ion binding]; other site 446462018350 beta-alpha-beta structure motif; other site 446462018351 NAD binding pocket [chemical binding]; other site 446462018352 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 446462018353 DNA binding residues [nucleotide binding] 446462018354 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462018355 putative dimer interface [polypeptide binding]; other site 446462018356 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446462018357 HSP70 interaction site [polypeptide binding]; other site 446462018358 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 446462018359 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446462018360 Zn binding sites [ion binding]; other site 446462018361 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446462018362 dimer interface [polypeptide binding]; other site 446462018363 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 446462018364 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 446462018365 dimer interface [polypeptide binding]; other site 446462018366 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446462018367 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 446462018368 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 446462018369 nucleotide binding site [chemical binding]; other site 446462018370 NEF interaction site [polypeptide binding]; other site 446462018371 SBD interface [polypeptide binding]; other site 446462018372 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446462018373 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446462018374 Ion transport protein; Region: Ion_trans; pfam00520 446462018375 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446462018376 4Fe-4S binding domain; Region: Fer4; pfam00037 446462018377 Cysteine-rich domain; Region: CCG; pfam02754 446462018378 Cysteine-rich domain; Region: CCG; pfam02754 446462018379 Membrane protein of unknown function; Region: DUF360; cl00850 446462018380 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 446462018381 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446462018382 trimer interface [polypeptide binding]; other site 446462018383 active site 446462018384 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 446462018385 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 446462018386 Na binding site [ion binding]; other site 446462018387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462018388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462018389 DNA binding residues [nucleotide binding] 446462018390 dimerization interface [polypeptide binding]; other site 446462018391 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 446462018392 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 446462018393 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 446462018394 FAD binding site [chemical binding]; other site 446462018395 substrate binding site [chemical binding]; other site 446462018396 catalytic residues [active] 446462018397 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 446462018398 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446462018399 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446462018400 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 446462018401 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 446462018402 VanW like protein; Region: VanW; pfam04294 446462018403 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446462018404 oligomerisation interface [polypeptide binding]; other site 446462018405 mobile loop; other site 446462018406 roof hairpin; other site 446462018407 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446462018408 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446462018409 YacP-like NYN domain; Region: NYN_YacP; cl01491 446462018410 Protein of unknown function (DUF541); Region: SIMPL; cl01077 446462018411 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 446462018412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446462018413 ligand binding site [chemical binding]; other site 446462018414 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 446462018415 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446462018416 dimer interface [polypeptide binding]; other site 446462018417 active site 446462018418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462018419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446462018420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462018421 NAD(P) binding site [chemical binding]; other site 446462018422 active site 446462018423 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446462018424 active site 1 [active] 446462018425 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446462018426 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446462018427 active site 446462018428 SCP-2 sterol transfer family; Region: SCP2; pfam02036 446462018429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462018430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446462018431 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446462018432 DNA binding residues [nucleotide binding] 446462018433 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 446462018434 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446462018435 E3 interaction surface; other site 446462018436 lipoyl attachment site [posttranslational modification]; other site 446462018437 e3 binding domain; Region: E3_binding; pfam02817 446462018438 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446462018439 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446462018440 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446462018441 alpha subunit interface [polypeptide binding]; other site 446462018442 TPP binding site [chemical binding]; other site 446462018443 heterodimer interface [polypeptide binding]; other site 446462018444 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446462018445 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446462018446 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446462018447 TPP-binding site [chemical binding]; other site 446462018448 tetramer interface [polypeptide binding]; other site 446462018449 heterodimer interface [polypeptide binding]; other site 446462018450 phosphorylation loop region [posttranslational modification] 446462018451 hypothetical protein; Provisional; Region: PRK07907 446462018452 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 446462018453 metal binding site [ion binding]; metal-binding site 446462018454 putative dimer interface [polypeptide binding]; other site 446462018455 alpha-glucosidase; Provisional; Region: PRK10137 446462018456 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446462018457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446462018458 substrate binding pocket [chemical binding]; other site 446462018459 membrane-bound complex binding site; other site 446462018460 hinge residues; other site 446462018461 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 446462018462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446462018463 putative PBP binding loops; other site 446462018464 dimer interface [polypeptide binding]; other site 446462018465 ABC-ATPase subunit interface; other site 446462018466 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446462018467 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446462018468 Walker A/P-loop; other site 446462018469 ATP binding site [chemical binding]; other site 446462018470 Q-loop/lid; other site 446462018471 ABC transporter signature motif; other site 446462018472 Walker B; other site 446462018473 D-loop; other site 446462018474 H-loop/switch region; other site 446462018475 Family of unknown function (DUF490); Region: DUF490; pfam04357 446462018476 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 446462018477 active site 446462018478 substrate-binding site [chemical binding]; other site 446462018479 metal-binding site [ion binding] 446462018480 GTP binding site [chemical binding]; other site 446462018481 Septum formation; Region: Septum_form; pfam13845 446462018482 Septum formation; Region: Septum_form; pfam13845 446462018483 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446462018484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446462018485 DNA-binding site [nucleotide binding]; DNA binding site 446462018486 FCD domain; Region: FCD; pfam07729 446462018487 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 446462018488 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 446462018489 Na binding site [ion binding]; other site 446462018490 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446462018491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446462018492 nucleotide binding site [chemical binding]; other site 446462018493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462018494 non-specific DNA binding site [nucleotide binding]; other site 446462018495 salt bridge; other site 446462018496 sequence-specific DNA binding site [nucleotide binding]; other site 446462018497 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446462018498 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446462018499 Dynamin family; Region: Dynamin_N; pfam00350 446462018500 G1 box; other site 446462018501 GTP/Mg2+ binding site [chemical binding]; other site 446462018502 G2 box; other site 446462018503 Switch I region; other site 446462018504 G3 box; other site 446462018505 Switch II region; other site 446462018506 G4 box; other site 446462018507 G5 box; other site 446462018508 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 446462018509 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446462018510 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446462018511 G1 box; other site 446462018512 GTP/Mg2+ binding site [chemical binding]; other site 446462018513 G2 box; other site 446462018514 Switch I region; other site 446462018515 G3 box; other site 446462018516 Switch II region; other site 446462018517 G4 box; other site 446462018518 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 446462018519 Histidine kinase; Region: HisKA_3; pfam07730 446462018520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462018521 ATP binding site [chemical binding]; other site 446462018522 Mg2+ binding site [ion binding]; other site 446462018523 G-X-G motif; other site 446462018524 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462018525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462018526 active site 446462018527 phosphorylation site [posttranslational modification] 446462018528 intermolecular recognition site; other site 446462018529 dimerization interface [polypeptide binding]; other site 446462018530 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462018531 DNA binding residues [nucleotide binding] 446462018532 dimerization interface [polypeptide binding]; other site 446462018533 short chain dehydrogenase; Provisional; Region: PRK08303 446462018534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462018535 NAD(P) binding site [chemical binding]; other site 446462018536 active site 446462018537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462018538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462018539 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446462018540 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 446462018541 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462018542 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 446462018543 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446462018544 putative dimer interface [polypeptide binding]; other site 446462018545 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446462018546 Histidine kinase; Region: HisKA_3; pfam07730 446462018547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462018548 ATP binding site [chemical binding]; other site 446462018549 Mg2+ binding site [ion binding]; other site 446462018550 G-X-G motif; other site 446462018551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446462018552 S-adenosylmethionine binding site [chemical binding]; other site 446462018553 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446462018554 active site 446462018555 catalytic residues [active] 446462018556 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446462018557 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446462018558 Walker A/P-loop; other site 446462018559 ATP binding site [chemical binding]; other site 446462018560 Q-loop/lid; other site 446462018561 ABC transporter signature motif; other site 446462018562 Walker B; other site 446462018563 D-loop; other site 446462018564 H-loop/switch region; other site 446462018565 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446462018566 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 446462018567 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446462018568 active site 446462018569 short chain dehydrogenase; Provisional; Region: PRK08219 446462018570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446462018571 NAD(P) binding site [chemical binding]; other site 446462018572 active site 446462018573 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 446462018574 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 446462018575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446462018576 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 446462018577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446462018578 active site 446462018579 motif I; other site 446462018580 motif II; other site 446462018581 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 446462018582 classical (c) SDRs; Region: SDR_c; cd05233 446462018583 NAD(P) binding site [chemical binding]; other site 446462018584 active site 446462018585 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 446462018586 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 446462018587 Predicted transcriptional regulators [Transcription]; Region: COG1695 446462018588 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446462018589 Transglycosylase; Region: Transgly; pfam00912 446462018590 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446462018591 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446462018592 Predicted integral membrane protein [Function unknown]; Region: COG5650 446462018593 Predicted integral membrane protein [Function unknown]; Region: COG5650 446462018594 endonuclease IV; Provisional; Region: PRK01060 446462018595 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 446462018596 AP (apurinic/apyrimidinic) site pocket; other site 446462018597 DNA interaction; other site 446462018598 Metal-binding active site; metal-binding site 446462018599 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 446462018600 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446462018601 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446462018602 dimer interface [polypeptide binding]; other site 446462018603 ssDNA binding site [nucleotide binding]; other site 446462018604 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446462018605 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 446462018606 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 446462018607 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 446462018608 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 446462018609 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446462018610 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446462018611 Walker A motif; other site 446462018612 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 446462018613 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446462018614 Walker A motif; other site 446462018615 ATP binding site [chemical binding]; other site 446462018616 Walker B motif; other site 446462018617 DNA binding loops [nucleotide binding] 446462018618 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446462018619 anti sigma factor interaction site; other site 446462018620 regulatory phosphorylation site [posttranslational modification]; other site 446462018621 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446462018622 classical (c) SDRs; Region: SDR_c; cd05233 446462018623 NAD(P) binding site [chemical binding]; other site 446462018624 active site 446462018625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446462018626 salt bridge; other site 446462018627 non-specific DNA binding site [nucleotide binding]; other site 446462018628 sequence-specific DNA binding site [nucleotide binding]; other site 446462018629 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446462018630 active site 446462018631 catalytic site [active] 446462018632 substrate binding site [chemical binding]; other site 446462018633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462018634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462018635 metal binding site [ion binding]; metal-binding site 446462018636 active site 446462018637 I-site; other site 446462018638 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 446462018639 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 446462018640 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446462018641 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446462018642 metal binding site [ion binding]; metal-binding site 446462018643 active site 446462018644 I-site; other site 446462018645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446462018646 ATP binding site [chemical binding]; other site 446462018647 Mg2+ binding site [ion binding]; other site 446462018648 G-X-G motif; other site 446462018649 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446462018650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446462018651 active site 446462018652 phosphorylation site [posttranslational modification] 446462018653 intermolecular recognition site; other site 446462018654 dimerization interface [polypeptide binding]; other site 446462018655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446462018656 DNA binding residues [nucleotide binding] 446462018657 dimerization interface [polypeptide binding]; other site 446462018658 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 446462018659 Immunity protein Imm1; Region: Imm1; pfam14430 446462018660 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446462018661 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446462018662 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 446462018663 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446462018664 putative NAD(P) binding site [chemical binding]; other site 446462018665 putative active site [active] 446462018666 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 446462018667 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 446462018668 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446462018669 NAD(P) binding site [chemical binding]; other site 446462018670 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 446462018671 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 446462018672 substrate-cofactor binding pocket; other site 446462018673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462018674 catalytic residue [active] 446462018675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462018676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446462018677 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446462018678 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446462018679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4861 446462018680 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 446462018681 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446462018682 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 446462018683 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446462018684 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446462018685 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446462018686 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446462018687 substrate binding site [chemical binding]; other site 446462018688 ATP binding site [chemical binding]; other site 446462018689 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446462018690 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446462018691 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446462018692 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 446462018693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462018694 active site 446462018695 HIGH motif; other site 446462018696 nucleotide binding site [chemical binding]; other site 446462018697 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 446462018698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462018699 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446462018700 active site 446462018701 KMSKS motif; other site 446462018702 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 446462018703 tRNA binding surface [nucleotide binding]; other site 446462018704 SdpI/YhfL protein family; Region: SdpI; pfam13630 446462018705 hypothetical protein; Validated; Region: PRK00228 446462018706 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 446462018707 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 446462018708 active site 446462018709 NTP binding site [chemical binding]; other site 446462018710 metal binding triad [ion binding]; metal-binding site 446462018711 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 446462018712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446462018713 Zn2+ binding site [ion binding]; other site 446462018714 Mg2+ binding site [ion binding]; other site 446462018715 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 446462018716 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446462018717 active site 446462018718 Ap6A binding site [chemical binding]; other site 446462018719 nudix motif; other site 446462018720 metal binding site [ion binding]; metal-binding site 446462018721 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 446462018722 MviN-like protein; Region: MVIN; pfam03023 446462018723 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 446462018724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446462018725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446462018726 DNA binding residues [nucleotide binding] 446462018727 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446462018728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446462018729 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446462018730 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446462018731 catalytic residues [active] 446462018732 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446462018733 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446462018734 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446462018735 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 446462018736 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 446462018737 active site 446462018738 metal binding site [ion binding]; metal-binding site 446462018739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446462018740 Coenzyme A binding pocket [chemical binding]; other site 446462018741 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446462018742 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446462018743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446462018744 homodimer interface [polypeptide binding]; other site 446462018745 catalytic residue [active] 446462018746 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 446462018747 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446462018748 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446462018749 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 446462018750 ParB-like nuclease domain; Region: ParBc; pfam02195 446462018751 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446462018752 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446462018753 P-loop; other site 446462018754 Magnesium ion binding site [ion binding]; other site 446462018755 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446462018756 Magnesium ion binding site [ion binding]; other site 446462018757 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 446462018758 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 446462018759 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 446462018760 nudix motif; other site 446462018761 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 446462018762 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 446462018763 G-X-X-G motif; other site 446462018764 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 446462018765 RxxxH motif; other site 446462018766 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 446462018767 Haemolytic domain; Region: Haemolytic; pfam01809 446462018768 Ribonuclease P; Region: Ribonuclease_P; cl00457 446462018769 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399